MXPA02012252A - Inhibidores de la reductasa 3-hidroxi-3-metilglutaril-coenzima a (hmg-coa) y metodo. - Google Patents
Inhibidores de la reductasa 3-hidroxi-3-metilglutaril-coenzima a (hmg-coa) y metodo.Info
- Publication number
- MXPA02012252A MXPA02012252A MXPA02012252A MXPA02012252A MXPA02012252A MX PA02012252 A MXPA02012252 A MX PA02012252A MX PA02012252 A MXPA02012252 A MX PA02012252A MX PA02012252 A MXPA02012252 A MX PA02012252A MX PA02012252 A MXPA02012252 A MX PA02012252A
- Authority
- MX
- Mexico
- Prior art keywords
- coa reductase
- reductase inhibitors
- hmg
- cholesterol
- cycloheteroalkyl
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Diabetes (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
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- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Gynecology & Obstetrics (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
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- Gastroenterology & Hepatology (AREA)
- AIDS & HIV (AREA)
- Dermatology (AREA)
- Child & Adolescent Psychology (AREA)
Abstract
La presente invencion se refiere a compuestos de la estructura (1) como inhibidores de la reductasa HMG CoA y por lo tanto son activos en la inhibicion de la biosíntesis del colesterol, modulacion de los lípidos del suero de la sangre, tal como la disminucion del colesterol LDL y/o incremento del colesterol HD1, y tratamiento de la hiperlipidemia, hipercolesterolemia, hipertrigliceridemia y aterosclerosis y sales de los mismos, farmacéuticamente aceptables, en donde X es O o S; 2 es (2) o (3); n es 0 o 1; R1 y R2 son los mismos o diferentes y se seleccionan de manera independiente de alquilo, arilalquilo, cicloalquilo, alquenilo, cicloalquenilo, arilo, heteroarilo o cicloheteroalquilo; R3 a R9 son como se definen aquí. (ver formula).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21159500P | 2000-06-15 | 2000-06-15 | |
PCT/US2001/018864 WO2001096347A1 (en) | 2000-06-15 | 2001-06-12 | HMG-CoA REDUCTASE INHIBITORS AND METHOD |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA02012252A true MXPA02012252A (es) | 2003-06-06 |
Family
ID=22787569
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA02012252A MXPA02012252A (es) | 2000-06-15 | 2001-06-12 | Inhibidores de la reductasa 3-hidroxi-3-metilglutaril-coenzima a (hmg-coa) y metodo. |
Country Status (22)
Country | Link |
---|---|
US (1) | US20020013334A1 (es) |
EP (1) | EP1294728A1 (es) |
JP (1) | JP2004503557A (es) |
KR (1) | KR20030036225A (es) |
CN (1) | CN1436192A (es) |
AR (1) | AR030700A1 (es) |
AU (1) | AU2001266858A1 (es) |
BR (1) | BR0111599A (es) |
CA (1) | CA2412632A1 (es) |
CZ (1) | CZ20023930A3 (es) |
EC (1) | ECSP024384A (es) |
HU (1) | HUP0302937A2 (es) |
IL (1) | IL152490A0 (es) |
MX (1) | MXPA02012252A (es) |
NO (1) | NO20026012L (es) |
NZ (1) | NZ523627A (es) |
PE (1) | PE20020254A1 (es) |
PL (1) | PL359820A1 (es) |
RU (1) | RU2003101064A (es) |
UY (1) | UY26777A1 (es) |
WO (1) | WO2001096347A1 (es) |
ZA (1) | ZA200210103B (es) |
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CN107164544A (zh) * | 2017-07-18 | 2017-09-15 | 孙葆青 | 通过高通量测序快速检测阿托伐他汀钙的敏感性的方法 |
EP3786479A4 (en) | 2018-04-27 | 2022-01-26 | Mitsuboshi Belting Ltd. | V-RIBBED BELT AND ITS APPLICATION |
CN110747206B (zh) * | 2019-11-05 | 2021-11-23 | 昆明理工大学 | 3-羟基-3-甲基戊二酸单酰辅酶a还原酶基因rkhmgr及其应用 |
CN114213350B (zh) * | 2021-12-29 | 2024-03-19 | 江苏福瑞康泰药业有限公司 | 一种他汀类药物中间体的制备方法 |
CN114437052B (zh) * | 2021-12-31 | 2024-03-29 | 江苏阿尔法集团福瑞药业(宿迁)有限公司 | 一种利用连续流微通道反应器合成他汀类药物中间体的方法 |
Family Cites Families (6)
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---|---|---|---|---|
NO177005C (no) * | 1988-01-20 | 1995-07-05 | Bayer Ag | Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen |
US5506219A (en) * | 1988-08-29 | 1996-04-09 | E. R. Squibb & Sons, Inc. | Pyridine anchors for HMG-CoA reductase inhibitors |
US5753675A (en) * | 1989-03-03 | 1998-05-19 | Novartis Pharmaceuticals Corporation | Quinoline analogs of mevalonolactone and derivatives thereof |
ZA911046B (en) * | 1990-02-26 | 1992-10-28 | Squibb & Sons Inc | Quinoline and pyridine anchors for hmg-coa reductase inhibitors |
US5177080A (en) * | 1990-12-14 | 1993-01-05 | Bayer Aktiengesellschaft | Substituted pyridyl-dihydroxy-heptenoic acid and its salts |
DE19627431A1 (de) * | 1996-07-08 | 1998-01-15 | Bayer Ag | Heterocyclisch kondensierte Pyridine |
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2001
- 2001-06-06 US US09/875,155 patent/US20020013334A1/en not_active Abandoned
- 2001-06-12 RU RU2003101064/04A patent/RU2003101064A/ru not_active Application Discontinuation
- 2001-06-12 NZ NZ523627A patent/NZ523627A/en unknown
- 2001-06-12 MX MXPA02012252A patent/MXPA02012252A/es unknown
- 2001-06-12 WO PCT/US2001/018864 patent/WO2001096347A1/en not_active Application Discontinuation
- 2001-06-12 EP EP01944447A patent/EP1294728A1/en not_active Withdrawn
- 2001-06-12 CN CN01811211A patent/CN1436192A/zh active Pending
- 2001-06-12 IL IL15249001A patent/IL152490A0/xx unknown
- 2001-06-12 AU AU2001266858A patent/AU2001266858A1/en not_active Abandoned
- 2001-06-12 PL PL35982001A patent/PL359820A1/xx not_active Application Discontinuation
- 2001-06-12 HU HU0302937A patent/HUP0302937A2/hu unknown
- 2001-06-12 JP JP2002510488A patent/JP2004503557A/ja active Pending
- 2001-06-12 KR KR1020027017086A patent/KR20030036225A/ko not_active Application Discontinuation
- 2001-06-12 CA CA002412632A patent/CA2412632A1/en not_active Abandoned
- 2001-06-12 CZ CZ20023930A patent/CZ20023930A3/cs unknown
- 2001-06-12 BR BR0111599-5A patent/BR0111599A/pt not_active IP Right Cessation
- 2001-06-15 UY UY26777A patent/UY26777A1/es not_active Application Discontinuation
- 2001-06-15 AR ARP010102886A patent/AR030700A1/es not_active Application Discontinuation
- 2001-06-15 PE PE2001000578A patent/PE20020254A1/es not_active Application Discontinuation
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2002
- 2002-12-12 ZA ZA200210103A patent/ZA200210103B/xx unknown
- 2002-12-13 EC EC2002004384A patent/ECSP024384A/es unknown
- 2002-12-13 NO NO20026012A patent/NO20026012L/no not_active Application Discontinuation
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JP2004503557A (ja) | 2004-02-05 |
KR20030036225A (ko) | 2003-05-09 |
BR0111599A (pt) | 2004-10-13 |
UY26777A1 (es) | 2002-01-31 |
IL152490A0 (en) | 2003-05-29 |
ZA200210103B (en) | 2004-03-12 |
ECSP024384A (es) | 2003-03-31 |
CZ20023930A3 (cs) | 2003-03-12 |
CA2412632A1 (en) | 2001-12-20 |
WO2001096347A1 (en) | 2001-12-20 |
NO20026012D0 (no) | 2002-12-13 |
CN1436192A (zh) | 2003-08-13 |
PE20020254A1 (es) | 2002-04-03 |
RU2003101064A (ru) | 2004-08-10 |
HUP0302937A2 (hu) | 2003-12-29 |
PL359820A1 (en) | 2004-09-06 |
EP1294728A1 (en) | 2003-03-26 |
AR030700A1 (es) | 2003-09-03 |
NO20026012L (no) | 2003-02-03 |
NZ523627A (en) | 2004-10-29 |
US20020013334A1 (en) | 2002-01-31 |
AU2001266858A1 (en) | 2001-12-24 |
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