MXPA02012252A - Inhibidores de la reductasa 3-hidroxi-3-metilglutaril-coenzima a (hmg-coa) y metodo. - Google Patents

Inhibidores de la reductasa 3-hidroxi-3-metilglutaril-coenzima a (hmg-coa) y metodo.

Info

Publication number
MXPA02012252A
MXPA02012252A MXPA02012252A MXPA02012252A MXPA02012252A MX PA02012252 A MXPA02012252 A MX PA02012252A MX PA02012252 A MXPA02012252 A MX PA02012252A MX PA02012252 A MXPA02012252 A MX PA02012252A MX PA02012252 A MXPA02012252 A MX PA02012252A
Authority
MX
Mexico
Prior art keywords
coa reductase
reductase inhibitors
hmg
cholesterol
cycloheteroalkyl
Prior art date
Application number
MXPA02012252A
Other languages
English (en)
Inventor
Bang-Chi Chen
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MXPA02012252A publication Critical patent/MXPA02012252A/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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Abstract

La presente invencion se refiere a compuestos de la estructura (1) como inhibidores de la reductasa HMG CoA y por lo tanto son activos en la inhibicion de la biosíntesis del colesterol, modulacion de los lípidos del suero de la sangre, tal como la disminucion del colesterol LDL y/o incremento del colesterol HD1, y tratamiento de la hiperlipidemia, hipercolesterolemia, hipertrigliceridemia y aterosclerosis y sales de los mismos, farmacéuticamente aceptables, en donde X es O o S; 2 es (2) o (3); n es 0 o 1; R1 y R2 son los mismos o diferentes y se seleccionan de manera independiente de alquilo, arilalquilo, cicloalquilo, alquenilo, cicloalquenilo, arilo, heteroarilo o cicloheteroalquilo; R3 a R9 son como se definen aquí. (ver formula).
MXPA02012252A 2000-06-15 2001-06-12 Inhibidores de la reductasa 3-hidroxi-3-metilglutaril-coenzima a (hmg-coa) y metodo. MXPA02012252A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21159500P 2000-06-15 2000-06-15
PCT/US2001/018864 WO2001096347A1 (en) 2000-06-15 2001-06-12 HMG-CoA REDUCTASE INHIBITORS AND METHOD

Publications (1)

Publication Number Publication Date
MXPA02012252A true MXPA02012252A (es) 2003-06-06

Family

ID=22787569

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02012252A MXPA02012252A (es) 2000-06-15 2001-06-12 Inhibidores de la reductasa 3-hidroxi-3-metilglutaril-coenzima a (hmg-coa) y metodo.

Country Status (22)

Country Link
US (1) US20020013334A1 (es)
EP (1) EP1294728A1 (es)
JP (1) JP2004503557A (es)
KR (1) KR20030036225A (es)
CN (1) CN1436192A (es)
AR (1) AR030700A1 (es)
AU (1) AU2001266858A1 (es)
BR (1) BR0111599A (es)
CA (1) CA2412632A1 (es)
CZ (1) CZ20023930A3 (es)
EC (1) ECSP024384A (es)
HU (1) HUP0302937A2 (es)
IL (1) IL152490A0 (es)
MX (1) MXPA02012252A (es)
NO (1) NO20026012L (es)
NZ (1) NZ523627A (es)
PE (1) PE20020254A1 (es)
PL (1) PL359820A1 (es)
RU (1) RU2003101064A (es)
UY (1) UY26777A1 (es)
WO (1) WO2001096347A1 (es)
ZA (1) ZA200210103B (es)

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CN110747206B (zh) * 2019-11-05 2021-11-23 昆明理工大学 3-羟基-3-甲基戊二酸单酰辅酶a还原酶基因rkhmgr及其应用
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