BRPI1013012A2 - identificação de pequenas moléculas reconhecidas por anticorpos em indivíduos com doenças neurodegenerativas - Google Patents

identificação de pequenas moléculas reconhecidas por anticorpos em indivíduos com doenças neurodegenerativas

Info

Publication number
BRPI1013012A2
BRPI1013012A2 BRPI1013012A BRPI1013012A BRPI1013012A2 BR PI1013012 A2 BRPI1013012 A2 BR PI1013012A2 BR PI1013012 A BRPI1013012 A BR PI1013012A BR PI1013012 A BRPI1013012 A BR PI1013012A BR PI1013012 A2 BRPI1013012 A2 BR PI1013012A2
Authority
BR
Brazil
Prior art keywords
individuals
identification
neurodegenerative diseases
small antibody
molecules
Prior art date
Application number
BRPI1013012A
Other languages
English (en)
Inventor
Dwight German
Johnnie Wilson
Reddy Moola
Rosemary Wilson
Steven Connell
Thomas Kodadek
Original Assignee
Opko Health Inc
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42269525&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI1013012(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Opko Health Inc, Univ Texas filed Critical Opko Health Inc
Publication of BRPI1013012A2 publication Critical patent/BRPI1013012A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BRPI1013012A 2009-06-02 2010-06-01 identificação de pequenas moléculas reconhecidas por anticorpos em indivíduos com doenças neurodegenerativas BRPI1013012A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18326009P 2009-06-02 2009-06-02
US31865510P 2010-03-29 2010-03-29
PCT/US2010/036827 WO2010141421A1 (en) 2009-06-02 2010-06-01 Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases

Publications (1)

Publication Number Publication Date
BRPI1013012A2 true BRPI1013012A2 (pt) 2016-10-18

Family

ID=42269525

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1013012A BRPI1013012A2 (pt) 2009-06-02 2010-06-01 identificação de pequenas moléculas reconhecidas por anticorpos em indivíduos com doenças neurodegenerativas

Country Status (16)

Country Link
US (1) US9551721B2 (pt)
EP (1) EP2438444A1 (pt)
JP (1) JP5828837B2 (pt)
KR (1) KR20120122869A (pt)
CN (1) CN102439451B (pt)
AU (1) AU2010256880B2 (pt)
BR (1) BRPI1013012A2 (pt)
CA (1) CA2764153C (pt)
CL (1) CL2011002973A1 (pt)
CO (1) CO6450654A2 (pt)
HK (1) HK1169709A1 (pt)
IL (1) IL216689A (pt)
MX (1) MX2011012933A (pt)
RU (1) RU2566064C2 (pt)
TW (1) TWI569014B (pt)
WO (1) WO2010141421A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014504594A (ja) 2011-01-10 2014-02-24 オプコ ファーマシューティカルズ、エルエルシー 自己免疫疾患における抗原代用物
MX2013011000A (es) * 2011-03-24 2014-03-27 Opko Pharmaceuticals Llc Descubrimiento de biomarcador en fluido biologico complejo usando genotecas basadas en microesferao particula y kits de diagnostico y terapeuticos.
WO2012154484A1 (en) * 2011-05-06 2012-11-15 Elwha Llc Compositions and methods for antibody and ligand identification
US11360098B2 (en) * 2015-09-28 2022-06-14 Quest Diagnostics Investments Llc Amyloid beta detection by mass spectrometry
AU2016338410B2 (en) 2015-10-14 2021-07-15 X-Therma, Inc. Compositions and methods for reducing ice crystal formation
WO2017156324A1 (en) 2016-03-09 2017-09-14 Mike-Ann, Llc Peptoid affinity ligands
WO2017165438A1 (en) 2016-03-25 2017-09-28 Muralidhar Reddy Moola Combinatorial synthesis and biomarker development
CN106866794B (zh) * 2017-02-15 2020-09-08 国家纳米科学中心 一种类肽及其制备方法和应用
CN108484905A (zh) * 2018-04-16 2018-09-04 青岛科技大学 一种侧链含羧基具有ucst行为的聚类肽及其制备方法
WO2019211878A1 (en) * 2018-05-04 2019-11-07 Council Of Scientific And Industrial Research, An Indian Registered Body Incorporated Under The Registration Of Societies Act (Act Xxi Of 1860) Peptoid of formula i, pharmaceutical compositions and method for preparation thereof
CN108586579B (zh) * 2018-05-11 2021-11-30 京东方科技集团股份有限公司 一种类肽及其衍生物、盐、制备方法和用途

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US5011771A (en) 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US4789628A (en) 1986-06-16 1988-12-06 Vxr, Inc. Devices for carrying out ligand/anti-ligand assays, methods of using such devices and diagnostic reagents and kits incorporating such devices
CA1304682C (en) 1986-11-19 1992-07-07 Nobuo Monji Membrane affinity concentration immunoassay
US5149626A (en) 1987-05-14 1992-09-22 Mclean Hospital Corporation Multiple antigen immunoassay
EP0317804B1 (en) 1987-11-24 1995-10-04 Abbott Laboratories HIV peptides and methods for detection of HIV
DE4040669A1 (de) 1990-12-19 1992-06-25 Behringwerke Ag Verwendung von peptidpaaren mit extrem hoher spezifischer affinitaet zueinander im bereich der in vitro diagnostik
DK51092D0 (da) 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
CA2115333A1 (en) 1993-02-16 1994-08-17 Shigeo Hozumi Polyfunctional vinyl ether compounds and photoresist resin composition containing the same
US5705614A (en) 1993-04-09 1998-01-06 Chiron Corporation Methods of producing antigen forks
JP3639594B2 (ja) 1993-05-28 2005-04-20 ベイラー カレッジ オブ メディシン 分析対象物の脱着およびイオン化のための方法および装置
ZA95605B (en) 1994-04-28 1995-12-20 Qualcomm Inc Method and apparatus for automatic gain control and dc offset cancellation in quadrature receiver
AUPO591797A0 (en) 1997-03-27 1997-04-24 Commonwealth Scientific And Industrial Research Organisation High avidity polyvalent and polyspecific reagents
ES2303338T3 (es) 1995-06-07 2008-08-01 Glaxo Group Limited Peptidos y compuestos que se unen a un receptor de trombopoyetina.
JPH1025299A (ja) 1996-07-12 1998-01-27 Nec Corp 整列ペプチド、及びそれを用いたタンパク質の結合・相互作用部位検出方法
US20020022227A1 (en) 1996-10-17 2002-02-21 Short Jay M. Morphatides: novel shape and structure libraries
US20020006620A1 (en) 1996-10-17 2002-01-17 Invitrogen Corporation Morphatides: novel shape and structure libraries
WO1998027209A1 (en) 1996-12-18 1998-06-25 Emory University Polycationic oligomers
WO1998046796A1 (en) 1997-04-11 1998-10-22 The Regents Of The University Of California A method of screening nucleotide sequences to identify disruptors or effectors of biological processes or pathways
NZ516848A (en) 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
US6344330B1 (en) 1998-03-27 2002-02-05 The Regents Of The University Of California Pharmacophore recombination for the identification of small molecule drug lead compounds
WO1999051773A1 (en) 1998-04-03 1999-10-14 Phylos, Inc. Addressable protein arrays
US6406632B1 (en) 1998-04-03 2002-06-18 Symyx Technologies, Inc. Rapid characterization of polymers
WO1999067640A1 (en) 1998-06-22 1999-12-29 The Regents Of The University Of California Triggered optical biosensor
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6780582B1 (en) 1998-07-14 2004-08-24 Zyomyx, Inc. Arrays of protein-capture agents and methods of use thereof
US6197599B1 (en) 1998-07-30 2001-03-06 Guorong Chin Method to detect proteins
US6306643B1 (en) 1998-08-24 2001-10-23 Affymetrix, Inc. Methods of using an array of pooled probes in genetic analysis
AU774367C (en) * 1998-11-06 2005-04-21 University Of Zurich Nucleotide and protein sequences of nogo genes and methods based thereon
AU4025300A (en) 1999-03-24 2000-10-09 Packard Bioscience Company Continuous porous matrix arrays
US6465183B2 (en) 1999-07-01 2002-10-15 Agilent Technologies, Inc. Multidentate arrays
WO2001027624A2 (en) 1999-10-08 2001-04-19 Superarray, Inc. Compositions and methods for detecting protein modification and enzymatic activity
WO2001033230A2 (en) 1999-11-02 2001-05-10 Chiron Corporation Biological sample component purification and differential display
AU2001233276A1 (en) 2000-02-03 2001-08-14 Immunomatrix Inc. Method and apparatus for signal transduction pathway profiling
EP1267904A4 (en) 2000-02-16 2006-02-08 Univ Northwestern POLYPEPTIDE PULMONAL TENSIDES
JP4860085B2 (ja) 2000-03-16 2012-01-25 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 表面結合リガンドから溶出された分析物を捕捉するための方法
CA2723664A1 (en) 2000-03-22 2001-09-27 Solulink, Incorporated Hydrazine-based and carbonyl-based bifunctional crosslinking reagents
AU2001259512B2 (en) 2000-05-04 2007-03-01 Yale University High density protein arrays for screening of protein activity
AU2001261533A1 (en) 2000-05-12 2001-11-26 Dumas, David P Compositions and methods for epitope mapping
US20020098493A1 (en) 2000-05-25 2002-07-25 Asher Nathan Drug-amino acids chimeric molecules
US7153682B2 (en) 2000-06-05 2006-12-26 Chiron Corporation Microarrays on mirrored substrates for performing proteomic analyses
US7148058B2 (en) 2000-06-05 2006-12-12 Chiron Corporation Protein microarrays on mirrored surfaces for performing proteomic analyses
ES2281424T3 (es) 2000-06-05 2007-10-01 Novartis Vaccines And Diagnostics, Inc. Micromatrices para llevar a cabo analisis proteomicos.
US20020013334A1 (en) * 2000-06-15 2002-01-31 Robl Jeffrey A. HMG-CoA reductase inhibitors and method
DE60130211T2 (de) 2000-06-23 2008-05-29 Domantis Ltd., Brentford Matrix-screening-verfahren
DK1309861T3 (da) 2000-08-15 2006-10-23 Discerna Ltd Funktionelle protein-arrays
AU2001285252A1 (en) 2000-08-25 2002-03-13 Gendaq, Ltd. Analysis of binding interactions
GB0022978D0 (en) 2000-09-19 2000-11-01 Oxford Glycosciences Uk Ltd Detection of peptides
EP1197755A1 (en) 2000-10-11 2002-04-17 Pepscan Systems B.V. Identification of protein binding sites
CA2432639A1 (en) 2000-11-16 2002-05-23 Cemines, Llc Profiling tumor specific markers for the diagnosis and treatment of neoplastic disease
US20020137104A1 (en) 2000-11-27 2002-09-26 Antonio Cosma High throughput determination of antigen expression
AU2002230788A1 (en) 2000-12-11 2002-06-24 Hk Pharmaceuticals, Inc. Multiplexed protein expression and activity assay
CA2434139C (en) 2001-01-23 2014-05-27 President And Fellows Of Harvard College Nucleic-acid programmable protein arrays
CA2435608A1 (en) 2001-02-05 2002-08-15 Graffinity Pharmaceutical Design Gmbh Low affinity screening method
US20020137106A1 (en) 2001-03-09 2002-09-26 Ciphergen Biosystems, Inc. Detection of biological pathway components
WO2002073209A2 (de) 2001-03-10 2002-09-19 Affina Immuntechnik Gmbh Verfahren zur identifikation von immunreaktiven epitopen auf proteinen
WO2002084249A2 (en) 2001-04-10 2002-10-24 The Board Of Trustees Of The Leland Stanford Junior University Therapeutic and diagnostic uses of antibody specificity profiles
WO2002084252A2 (en) 2001-04-17 2002-10-24 Xenoport, Inc. Epitope-captured antibody display
JP2004536290A (ja) 2001-04-19 2004-12-02 ゲゼルシャフト　フュア　バイオテクノロギッシェ　フォーシュンク　エム　ベー　ハー（ゲー　ベー　エフ） 安定した、再生可能な抗体アレイの作製方法
US6989276B2 (en) 2001-05-10 2006-01-24 Battelle Energy Alliance, Llc Rapid classification of biological components
WO2003019192A1 (en) 2001-08-27 2003-03-06 The Trustees Of Boston University Apparatus, composition and method for proteome profiling
AU2002367732A1 (en) 2001-10-31 2003-09-09 Children's Hospital Medical Center Method for diagnosis and treatment of rheumatoid arthritis
EP1319954A1 (en) 2001-12-12 2003-06-18 Centre National de Genotypage Methods for protein analysis using protein capture arrays
US7504364B2 (en) 2002-03-01 2009-03-17 Receptors Llc Methods of making arrays and artificial receptors
EP1565744A4 (en) 2002-03-07 2007-06-20 Zephyr Proteomix Ltd MICROARRAY'S CELLULOSE BINDING CHIMERIC PROTEINS AND METHOD OF USE THEREOF
US7736909B2 (en) 2003-01-09 2010-06-15 Board Of Regents, The University Of Texas System Methods and compositions comprising capture agents
WO2005007677A2 (en) 2003-07-10 2005-01-27 The Institute For Systems Biology Affinity capture of peptides by microarray and related methods
GB2404734A (en) 2003-08-05 2005-02-09 Secr Defence A method of screening a sample for abnormally glycosylated and/or expressed proteins
WO2006028930A2 (en) 2004-09-03 2006-03-16 Receptors Llc Combinatorial artificial receptors including tether building blocks on scaffolds
EP1688137A1 (en) * 2005-01-28 2006-08-09 Schwarz Pharma Ag SPM 927 for add-on therapy of schizophrenia
WO2006124644A2 (en) * 2005-05-12 2006-11-23 Board Of Regents, The University Of Texas System Protein and antibody profiling using small molecule microarrays
CA2621767A1 (en) 2005-09-09 2007-03-15 Novartis Ag Prion-specific peptoid reagents
CA2666507A1 (en) 2006-10-16 2008-04-24 The Arizona Board Of Regents, A Body Corporate Of The State Of Arizona A Cting For And On Behalf Of Arizona State University Synthetic antibodies
KR20120034683A (ko) 2009-05-29 2012-04-12 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 자가면역 ｔ-세포의 분리 및 처리를 위한 펩토이드 리간드

Also Published As

Publication number Publication date
KR20120122869A (ko) 2012-11-07
CN102439451B (zh) 2014-12-03
MX2011012933A (es) 2012-03-07
CN102439451A (zh) 2012-05-02
US20100303805A1 (en) 2010-12-02
RU2566064C2 (ru) 2015-10-20
TWI569014B (zh) 2017-02-01
EP2438444A1 (en) 2012-04-11
AU2010256880B2 (en) 2015-01-22
CA2764153C (en) 2021-07-27
JP2012529053A (ja) 2012-11-15
HK1169709A1 (en) 2013-02-01
US9551721B2 (en) 2017-01-24
AU2010256880A1 (en) 2011-11-03
CA2764153A1 (en) 2010-12-09
IL216689A (en) 2016-09-29
CO6450654A2 (es) 2012-05-31
WO2010141421A1 (en) 2010-12-09
CL2011002973A1 (es) 2012-03-23
JP5828837B2 (ja) 2015-12-09
IL216689A0 (en) 2012-02-29
TW201109662A (en) 2011-03-16

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001

B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements
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