SI2665723T1 - Postopek priprave statinov v prisotnosti baze - Google Patents
Postopek priprave statinov v prisotnosti bazeInfo
- Publication number
- SI2665723T1 SI2665723T1 SI201230331T SI201230331T SI2665723T1 SI 2665723 T1 SI2665723 T1 SI 2665723T1 SI 201230331 T SI201230331 T SI 201230331T SI 201230331 T SI201230331 T SI 201230331T SI 2665723 T1 SI2665723 T1 SI 2665723T1
- Authority
- SI
- Slovenia
- Prior art keywords
- statins
- preparation
- base
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11151280 | 2011-01-18 | ||
| EP11184685 | 2011-10-11 | ||
| PCT/EP2012/050470 WO2012098049A1 (en) | 2011-01-18 | 2012-01-13 | Process for the preparation of statins in the presence of base |
| EP12701325.8A EP2665723B1 (en) | 2011-01-18 | 2012-01-13 | Process for the preparation of statins in the presence of base |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2665723T1 true SI2665723T1 (sl) | 2015-11-30 |
Family
ID=45540862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201230331T SI2665723T1 (sl) | 2011-01-18 | 2012-01-13 | Postopek priprave statinov v prisotnosti baze |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9126975B2 (sl) |
| EP (1) | EP2665723B1 (sl) |
| CN (1) | CN103313983B (sl) |
| HU (1) | HUE025730T2 (sl) |
| IL (1) | IL227098A (sl) |
| MX (1) | MX357470B (sl) |
| SI (1) | SI2665723T1 (sl) |
| WO (1) | WO2012098049A1 (sl) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104513232A (zh) * | 2015-01-08 | 2015-04-15 | 苏州莱克施德药业有限公司 | 罗舒伐他汀乙酯的制备工艺 |
| CN106588763A (zh) * | 2016-10-09 | 2017-04-26 | 江南大学 | 一种利用改进的Julia烯烃化反应为核心步骤制备他汀类原料药中间体的方法 |
| CN111454216B (zh) * | 2019-10-21 | 2021-06-29 | 山东理工职业学院 | HMG-CoA还原酶抑制剂及其中间体的制备方法 |
| IL292532B1 (en) | 2019-10-31 | 2024-04-01 | Kumiai Chemical Industry Co | Process for the production of herbicide and its intermediates |
| CN114502551B (zh) | 2019-11-01 | 2023-08-22 | 优迈特株式会社 | 含氟嘧啶化合物及其制备方法 |
| CN112028881B (zh) * | 2020-09-02 | 2023-08-15 | 能特科技有限公司 | 一种瑞舒伐他汀钙的高级中间体r-1的合成方法 |
| CN113754650B (zh) * | 2021-08-06 | 2023-10-20 | 湖北宇阳药业有限公司 | 一种瑞舒伐他汀钙中间体的高选择性合成方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2648897B2 (ja) | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
| WO1995011898A1 (en) * | 1992-05-12 | 1995-05-04 | Nissan Chemical Industries Ltd. | Condensed pyridine type mevalonolactone intermediate and process for its production |
| DE69937374T2 (de) | 1998-08-05 | 2008-07-24 | Kaneka Corp. | Verfahren zur Herstellung von 3,5-dihydroxy substituierten Estern als Zwischenprodukte zur Herstellung optisch aktiver 2-(6-(Hydroxymethyl)-1,3-dioxan-4-yl)-essigsäure-Derivate |
| GB9903472D0 (en) | 1999-02-17 | 1999-04-07 | Zeneca Ltd | Chemical process |
| US20020028826A1 (en) | 2000-06-15 | 2002-03-07 | Robl Jeffrey A. | HMG-CoA reductase inhibitors and method |
| NL1015744C2 (nl) | 2000-07-19 | 2002-01-22 | Dsm Nv | Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten. |
| TR200400600T3 (tr) | 2001-06-06 | 2004-06-21 | Bristol-Myers Squibb Company | Kiral diol sülfonlar ve dihidroksi asit HMG COA redüktaz inhibitörlerinin hazırlanmsı için işlem |
| JP2005503393A (ja) * | 2001-08-22 | 2005-02-03 | チバ スペシャルティ ケミカルズ ホールディング インコーポレーテッド | インドール誘導体の製造方法 |
| GB0324791D0 (en) * | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
| CZ299215B6 (cs) | 2005-06-29 | 2008-05-21 | Zentiva, A. S. | Zpusob výroby hemivápenaté soli (E)-7-[4-(4-fluorofenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl] (3R,5S)-3,5-dihydroxy-6-heptenovékyseliny |
| US8404841B2 (en) | 2006-10-09 | 2013-03-26 | Msn Laboratories Limited | Process for the preparation of statins and their pharmaceutically acceptable salts thereof |
| KR20100080432A (ko) * | 2008-12-29 | 2010-07-08 | 한미약품 주식회사 | 스타틴 화합물의 신규 제조방법 및 이에 사용되는 벤조티아졸릴 술폰 화합물 |
| KR101091130B1 (ko) * | 2009-01-29 | 2011-12-09 | (주)유케이케미팜 | 로슈바스타틴의 전구체 및 그의 제조 방법 |
| KR101157314B1 (ko) * | 2009-06-05 | 2012-06-15 | 주식회사종근당 | 로수바스타틴의 신규한 제조방법, 이 제조에 유용한 중간체 화합물 및 그의 제조방법 |
-
2012
- 2012-01-13 CN CN201280005629.4A patent/CN103313983B/zh active Active
- 2012-01-13 HU HUE12701325A patent/HUE025730T2/en unknown
- 2012-01-13 MX MX2013008293A patent/MX357470B/es active IP Right Grant
- 2012-01-13 SI SI201230331T patent/SI2665723T1/sl unknown
- 2012-01-13 EP EP12701325.8A patent/EP2665723B1/en active Active
- 2012-01-13 US US13/979,976 patent/US9126975B2/en active Active
- 2012-01-13 WO PCT/EP2012/050470 patent/WO2012098049A1/en active Application Filing
-
2013
- 2013-06-20 IL IL227098A patent/IL227098A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| HUE025730T2 (en) | 2016-04-28 |
| MX357470B (es) | 2018-07-11 |
| US20130296561A1 (en) | 2013-11-07 |
| CN103313983B (zh) | 2016-06-29 |
| MX2013008293A (es) | 2013-10-03 |
| CN103313983A (zh) | 2013-09-18 |
| EP2665723A1 (en) | 2013-11-27 |
| US9126975B2 (en) | 2015-09-08 |
| EP2665723B1 (en) | 2015-07-22 |
| IL227098A (en) | 2016-09-29 |
| WO2012098049A1 (en) | 2012-07-26 |
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