TR200400600T3 - Kiral diol sülfonlar ve dihidroksi asit HMG COA redüktaz inhibitörlerinin hazırlanmsı için işlem - Google Patents

Kiral diol sülfonlar ve dihidroksi asit HMG COA redüktaz inhibitörlerinin hazırlanmsı için işlem

Info

Publication number
TR200400600T3
TR200400600T3 TR2004/00600T TR200400600T TR200400600T3 TR 200400600 T3 TR200400600 T3 TR 200400600T3 TR 2004/00600 T TR2004/00600 T TR 2004/00600T TR 200400600 T TR200400600 T TR 200400600T TR 200400600 T3 TR200400600 T3 TR 200400600T3
Authority
TR
Turkey
Prior art keywords
preparation
coa reductase
reductase inhibitors
hmg coa
chiral diol
Prior art date
Application number
TR2004/00600T
Other languages
English (en)
Inventor
R. Brodfuehrer Paul
Thomas R. Sattelberg, Sr.
Kant Joydeep
Qian Xinhua
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of TR200400600T3 publication Critical patent/TR200400600T3/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

R3' ün tercihan (II) ya da (III) oldugu (I) yapisina sahip olan kiral diol sülfonlarin hazirlanmasi için bir islem temin edilmistir, bu formüllerde, R4a, tercihan fenil gibi arildir ve R1a, tercihan t-butil gibi alkildir, bu maddeler, HMG CoA redüktaz inhibitörlerinin hazirlanmasinda kullanilan ara-maddelerdir.
TR2004/00600T 2001-06-06 2002-05-30 Kiral diol sülfonlar ve dihidroksi asit HMG COA redüktaz inhibitörlerinin hazırlanmsı için işlem TR200400600T3 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29640301P 2001-06-06 2001-06-06

Publications (1)

Publication Number Publication Date
TR200400600T3 true TR200400600T3 (tr) 2004-06-21

Family

ID=23141867

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2004/00600T TR200400600T3 (tr) 2001-06-06 2002-05-30 Kiral diol sülfonlar ve dihidroksi asit HMG COA redüktaz inhibitörlerinin hazırlanmsı için işlem

Country Status (17)

Country Link
US (2) US6875867B2 (tr)
EP (1) EP1392656A4 (tr)
JP (1) JP2004536813A (tr)
KR (1) KR20040007657A (tr)
CN (1) CN1656077A (tr)
BR (1) BR0209942A (tr)
CA (1) CA2449813A1 (tr)
CZ (1) CZ20033329A3 (tr)
DE (1) DE02737324T1 (tr)
ES (1) ES2214169T1 (tr)
HU (1) HUP0401724A2 (tr)
IL (1) IL158525A0 (tr)
MX (1) MXPA03011195A (tr)
PL (1) PL367133A1 (tr)
TR (1) TR200400600T3 (tr)
TW (1) TWI256391B (tr)
WO (1) WO2002098854A2 (tr)

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UY28501A1 (es) * 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0321827D0 (en) * 2003-09-18 2003-10-15 Astrazeneca Uk Ltd Chemical compounds
GB0324791D0 (en) * 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
GB0428328D0 (en) * 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
GB0514078D0 (en) * 2005-07-08 2005-08-17 Astrazeneca Uk Ltd Chemical process
US7659281B2 (en) 2006-04-25 2010-02-09 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors
ES2564250T3 (es) * 2006-05-03 2016-03-21 Msn Laboratories Private Limited Nuevo proceso para estatinas y sus sales farmacéuticamente aceptables de las mismas
WO2008044243A2 (en) 2006-10-09 2008-04-17 Manne Satyanarayana Reddy Novel process for the preparation of statins and their pharmaceutically acceptable salts thereof
TW200831469A (en) * 2006-12-01 2008-08-01 Astrazeneca Uk Ltd Chemical process
WO2010089770A2 (en) 2009-01-19 2010-08-12 Msn Laboratories Limited Improved process for the preparation of highly pure (3r,5s)-7-[2-cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxy-6(e)-heptenoic acid and pharmaceutically acceptable salts thereof
KR101157314B1 (ko) * 2009-06-05 2012-06-15 주식회사종근당 로수바스타틴의 신규한 제조방법, 이 제조에 유용한 중간체 화합물 및 그의 제조방법
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SI2665721T1 (sl) * 2011-01-18 2015-10-30 Dsm Sinochem Pharmaceuticals Netherlands B.V. Metiltetrazol sulfidi in sulfoni
CN102174039B (zh) * 2011-03-10 2013-11-06 上海交通大学 高光学纯匹伐他汀钙关键中间体的制备方法
WO2012140490A2 (en) 2011-04-11 2012-10-18 Aurobindo Pharma Limited Process for preparing quinoline derivative
CN102816152B (zh) * 2011-06-09 2015-09-09 上海京新生物医药有限公司 一种瑞苏伐他汀中间体的制备方法
WO2013010488A1 (en) 2011-07-19 2013-01-24 Sunshine Lake Pharma Co., Ltd. An intermediate of statin drugs and preparation thereof
WO2013083719A1 (en) 2011-12-09 2013-06-13 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the preparation of a thioprecursor for statins
EP2788342B1 (en) * 2011-12-09 2018-01-24 DSM Sinochem Pharmaceuticals Netherlands B.V. Process for the preparation of a statin precursor
CZ304171B6 (cs) * 2011-12-16 2013-12-04 Zentiva, K.S. Zpusob prípravy chránených chirálních sulfon - diolu
WO2014108795A2 (en) 2013-01-10 2014-07-17 Aurobindo Pharma Limited An improved process for the preparation of chiral diol sulfones and statins
CN103360384A (zh) * 2013-07-30 2013-10-23 浙江京新药业股份有限公司 HMG-CoA还原酶抑制剂关键中间体的合成方法
CN103694228B (zh) * 2013-12-18 2018-08-28 北京华禧联合科技发展有限公司 一种制备匹伐他汀钙关键中间体的方法
WO2016125086A1 (en) * 2015-02-03 2016-08-11 Laurus Labs Private Limited Processes for the preparation of rosuvastatin or pharmaceutically acceptable salts thereof
CN109574939B (zh) * 2017-09-28 2022-05-27 安徽省庆云医药股份有限公司 一种瑞舒伐他汀钠的制备方法
CN109574999B (zh) * 2017-09-28 2022-03-08 安徽省庆云医药股份有限公司 一种匹伐他汀钙中间体的制备方法
CN111454216B (zh) * 2019-10-21 2021-06-29 山东理工职业学院 HMG-CoA还原酶抑制剂及其中间体的制备方法
CN112159403B (zh) 2020-09-30 2022-04-15 复旦大学 一种用于合成他汀类药物的关键中间体的制备方法
CN112679490A (zh) * 2021-01-28 2021-04-20 安徽美诺华药物化学有限公司 瑞舒伐他汀钙含砜结构的手性侧链及其制备方法与用途
CN114213350B (zh) * 2021-12-29 2024-03-19 江苏福瑞康泰药业有限公司 一种他汀类药物中间体的制备方法

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Also Published As

Publication number Publication date
PL367133A1 (en) 2005-02-21
US6875867B2 (en) 2005-04-05
IL158525A0 (en) 2004-05-12
BR0209942A (pt) 2004-03-30
WO2002098854A3 (en) 2003-03-27
ES2214169T1 (es) 2004-09-16
EP1392656A4 (en) 2005-04-06
TWI256391B (en) 2006-06-11
EP1392656A2 (en) 2004-03-03
KR20040007657A (ko) 2004-01-24
HUP0401724A2 (hu) 2004-12-28
DE02737324T1 (de) 2004-07-15
MXPA03011195A (es) 2004-03-18
CZ20033329A3 (cs) 2004-11-10
US20050124641A1 (en) 2005-06-09
CN1656077A (zh) 2005-08-17
WO2002098854A2 (en) 2002-12-12
CA2449813A1 (en) 2002-12-12
JP2004536813A (ja) 2004-12-09
US20030018199A1 (en) 2003-01-23

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