MXPA03000772A - Derivados de acido hexahidro-7-1h-azepin-2-il-hexanoico como inhibidores de oxido nitrico sintasa inducible. - Google Patents
Derivados de acido hexahidro-7-1h-azepin-2-il-hexanoico como inhibidores de oxido nitrico sintasa inducible.Info
- Publication number
- MXPA03000772A MXPA03000772A MXPA03000772A MXPA03000772A MXPA03000772A MX PA03000772 A MXPA03000772 A MX PA03000772A MX PA03000772 A MXPA03000772 A MX PA03000772A MX PA03000772 A MXPA03000772 A MX PA03000772A MX PA03000772 A MXPA03000772 A MX PA03000772A
- Authority
- MX
- Mexico
- Prior art keywords
- azepin
- hexahydro
- inhibitors
- acid derivatives
- nitric oxide
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
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- C07D223/08—Oxygen atoms
- C07D223/10—Oxygen atoms attached in position 2
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22217900P | 2000-08-01 | 2000-08-01 | |
PCT/US2001/024542 WO2002010139A1 (en) | 2000-08-01 | 2001-08-01 | Hexahydro-7-1h-azepin-2-yl-haxanoic acid derivatives as inhibitors of inducible nitric oxide synthase |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA03000772A true MXPA03000772A (es) | 2003-06-04 |
Family
ID=22831203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA03000772A MXPA03000772A (es) | 2000-08-01 | 2001-08-01 | Derivados de acido hexahidro-7-1h-azepin-2-il-hexanoico como inhibidores de oxido nitrico sintasa inducible. |
Country Status (11)
Country | Link |
---|---|
US (1) | US6495544B2 (es) |
EP (1) | EP1305293A1 (es) |
JP (1) | JP2004512271A (es) |
AR (1) | AR032360A1 (es) |
AU (1) | AU2001281083A1 (es) |
CA (1) | CA2415851A1 (es) |
EA (1) | EA005817B1 (es) |
MX (1) | MXPA03000772A (es) |
NZ (1) | NZ523770A (es) |
PE (1) | PE20030413A1 (es) |
WO (1) | WO2002010139A1 (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
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US7879840B2 (en) | 2005-08-25 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
US7393652B2 (en) | 2000-05-10 | 2008-07-01 | The Trustees Of Columbia University In The City Of New York | Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2) |
US8022058B2 (en) | 2000-05-10 | 2011-09-20 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
US7718644B2 (en) | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
KR20050004155A (ko) * | 2002-05-16 | 2005-01-12 | 파마시아 코포레이션 | 선택적 유도성 산화질소 신타아제 억제제를 이용한 호흡기질병 및 질환의 치료 방법 |
US7544678B2 (en) | 2002-11-05 | 2009-06-09 | The Trustees Of Columbia University In The City Of New York | Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) |
WO2004062575A2 (en) * | 2003-01-07 | 2004-07-29 | Kemin Pharma Europe Bvba | Bicyclic carbohydrate compounds useful in the treatment of infections caused by flaviviridae sp., such as hepatitis c and bovine viral diarrhea viruses |
AU2004220548A1 (en) | 2003-03-07 | 2004-09-23 | The Trustees Of Columbia University, In The City Of New York | Type 1 ryanodine receptor-based methods |
US7550590B2 (en) | 2003-03-25 | 2009-06-23 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7638638B2 (en) | 2003-05-14 | 2009-12-29 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
ZA200602051B (en) | 2003-08-13 | 2007-10-31 | Takeda Pharmaceutical | 4-pyrimidone derivatives and their use as peptidyl peptidase inhibitors |
US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
WO2005026148A1 (en) | 2003-09-08 | 2005-03-24 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
US8710045B2 (en) | 2004-01-22 | 2014-04-29 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the ryanodine receptors |
US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
CN102127053A (zh) * | 2004-03-15 | 2011-07-20 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
US7687638B2 (en) | 2004-06-04 | 2010-03-30 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
WO2006014206A1 (en) * | 2004-07-02 | 2006-02-09 | Allergan, Inc. | Prostaglandin analogs |
WO2006019965A2 (en) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
DE102004052697A1 (de) * | 2004-10-29 | 2006-05-04 | Haehner, Thomas, Dr. | Pharmazeutische Zubereitungen zur Behandlung von Folgen des Alkoholmissbrauchs, Hepatitis, Pankreatitis, Alzheimererkrankung, Morbus Parkinson, Diabetes, toxischen Nierenerkrankungen, Reperfusionsschäden, der Arteriosklerose sowie als Antidote gegen Umweltgifte und Medikamentenintoxikation |
US7872124B2 (en) | 2004-12-21 | 2011-01-18 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
ATE433975T1 (de) | 2005-03-31 | 2009-07-15 | Nycomed Gmbh | Als inos-inhibitoren geeignete imidazopyridinderivate |
US7704990B2 (en) | 2005-08-25 | 2010-04-27 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
DK1942898T4 (da) | 2005-09-14 | 2014-06-02 | Takeda Pharmaceutical | Dipeptidylpeptidase-inhibitorer til behandling af diabetes |
WO2007033265A1 (en) * | 2005-09-14 | 2007-03-22 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors for treating diabetis |
KR101368988B1 (ko) | 2005-09-16 | 2014-02-28 | 다케다 야쿠힌 고교 가부시키가이샤 | 디펩티딜 펩티다제 억제제 |
WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
WO2008031788A1 (en) * | 2006-09-12 | 2008-03-20 | Nycomed Gmbh | Aminoazepine derivatives as highly efficient inhibitors of the inducible nitric oxide synthase |
US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
PE20081150A1 (es) * | 2006-09-13 | 2008-10-03 | Takeda Pharmaceutical | Inhibidores de dipetidilpeptidasa |
TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
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Family Cites Families (6)
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JP2648897B2 (ja) | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
CN1077886C (zh) | 1993-10-21 | 2002-01-16 | G·D·瑟尔公司 | 用作一氧化一氮合酶抑制剂的脒基衍生物 |
US5994391A (en) | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
EP0821674B1 (en) * | 1995-04-20 | 2003-08-06 | G.D. SEARLE & CO. | Cyclic amidino agents useful as nitric oxide synthase inhibitors |
GB9516709D0 (en) | 1995-08-15 | 1995-10-18 | Zeneca Ltd | Medicament |
JP2002517502A (ja) * | 1998-06-10 | 2002-06-18 | ジー・ディー・サール・アンド・カンパニー | 複素二環状及び三環状一酸化窒素シンターゼ阻害剤 |
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2001
- 2001-08-01 CA CA002415851A patent/CA2415851A1/en not_active Abandoned
- 2001-08-01 US US09/920,612 patent/US6495544B2/en not_active Expired - Fee Related
- 2001-08-01 AU AU2001281083A patent/AU2001281083A1/en not_active Abandoned
- 2001-08-01 AR ARP010103682A patent/AR032360A1/es unknown
- 2001-08-01 NZ NZ523770A patent/NZ523770A/en unknown
- 2001-08-01 JP JP2002516271A patent/JP2004512271A/ja not_active Withdrawn
- 2001-08-01 EP EP01959537A patent/EP1305293A1/en not_active Withdrawn
- 2001-08-01 EA EA200300030A patent/EA005817B1/ru not_active IP Right Cessation
- 2001-08-01 MX MXPA03000772A patent/MXPA03000772A/es unknown
- 2001-08-01 WO PCT/US2001/024542 patent/WO2002010139A1/en not_active Application Discontinuation
- 2001-10-09 PE PE2001000771A patent/PE20030413A1/es not_active Application Discontinuation
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WO2002010139A1 (en) | 2002-02-07 |
JP2004512271A (ja) | 2004-04-22 |
EP1305293A1 (en) | 2003-05-02 |
US6495544B2 (en) | 2002-12-17 |
AU2001281083A1 (en) | 2002-02-13 |
CA2415851A1 (en) | 2002-02-07 |
AR032360A1 (es) | 2003-11-05 |
PE20030413A1 (es) | 2003-05-20 |
EA200300030A1 (ru) | 2003-08-28 |
EA005817B1 (ru) | 2005-06-30 |
US20020119964A1 (en) | 2002-08-29 |
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