AR032360A1 - Compuesto derivado de acido homoiminopiperidinil hexanoico, composicion farmaceutica que lo comprende y compuestos intermediarios que se usan en su preparacion - Google Patents
Compuesto derivado de acido homoiminopiperidinil hexanoico, composicion farmaceutica que lo comprende y compuestos intermediarios que se usan en su preparacionInfo
- Publication number
- AR032360A1 AR032360A1 ARP010103682A ARP010103682A AR032360A1 AR 032360 A1 AR032360 A1 AR 032360A1 AR P010103682 A ARP010103682 A AR P010103682A AR P010103682 A ARP010103682 A AR P010103682A AR 032360 A1 AR032360 A1 AR 032360A1
- Authority
- AR
- Argentina
- Prior art keywords
- pharmaceutical composition
- compounds used
- preparation
- compound derived
- hexanoic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C07D223/10—Oxygen atoms attached in position 2
Abstract
Compuesto derivado del ácido homoiminopiperidinil hexanoico de formulas 1 a 3 y sales del mismo aceptable para el uso farmacéutico util en la inhibicion de la isoforma inducible de la oxido nítrico sintetasa. La composicion farmacéutica que lo comprende y los compuestos intermediarios utilizados en su preparacion seleccionados del grupo de formulas del 4 a 9.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22217900P | 2000-08-01 | 2000-08-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR032360A1 true AR032360A1 (es) | 2003-11-05 |
Family
ID=22831203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010103682A AR032360A1 (es) | 2000-08-01 | 2001-08-01 | Compuesto derivado de acido homoiminopiperidinil hexanoico, composicion farmaceutica que lo comprende y compuestos intermediarios que se usan en su preparacion |
Country Status (11)
Country | Link |
---|---|
US (1) | US6495544B2 (es) |
EP (1) | EP1305293A1 (es) |
JP (1) | JP2004512271A (es) |
AR (1) | AR032360A1 (es) |
AU (1) | AU2001281083A1 (es) |
CA (1) | CA2415851A1 (es) |
EA (1) | EA005817B1 (es) |
MX (1) | MXPA03000772A (es) |
NZ (1) | NZ523770A (es) |
PE (1) | PE20030413A1 (es) |
WO (1) | WO2002010139A1 (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7718644B2 (en) | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
US7393652B2 (en) | 2000-05-10 | 2008-07-01 | The Trustees Of Columbia University In The City Of New York | Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2) |
US7879840B2 (en) | 2005-08-25 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
US8022058B2 (en) | 2000-05-10 | 2011-09-20 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
BR0311180A (pt) * | 2002-05-16 | 2005-03-01 | Pharmacia Corp | Métodos para o tratamento de doenças e condições respiratórias utilizando um inibidor seletivo da inos |
US7544678B2 (en) | 2002-11-05 | 2009-06-09 | The Trustees Of Columbia University In The City Of New York | Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) |
CA2512713C (en) * | 2003-01-07 | 2012-03-13 | Kemin Pharma Europe, B.V.B.A. | Bicyclic carbohydrate compounds useful in the treatment of infections caused by flaviviridae sp., such as hepatitis c and bovine viral diarrhea viruses |
EP1603450A4 (en) | 2003-03-07 | 2009-07-29 | Univ Columbia | METHODS USING TYPE 1 RYANODINE RECEPTOR |
JP4887139B2 (ja) | 2003-03-25 | 2012-02-29 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼインヒビター |
EP1625122A1 (en) | 2003-05-14 | 2006-02-15 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
ZA200602051B (en) | 2003-08-13 | 2007-10-31 | Takeda Pharmaceutical | 4-pyrimidone derivatives and their use as peptidyl peptidase inhibitors |
US7790734B2 (en) | 2003-09-08 | 2010-09-07 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US8710045B2 (en) | 2004-01-22 | 2014-04-29 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the ryanodine receptors |
US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
GEP20094679B (en) | 2004-03-15 | 2009-05-10 | Takeda Pharmaceuticals Co | Dipeptidyl peptidase inhibitors |
JP2008501714A (ja) | 2004-06-04 | 2008-01-24 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼインヒビター |
US7326698B2 (en) * | 2004-07-02 | 2008-02-05 | Allergan, Inc. | Prostaglandin analogs |
WO2006019965A2 (en) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
DE102004052697A1 (de) * | 2004-10-29 | 2006-05-04 | Haehner, Thomas, Dr. | Pharmazeutische Zubereitungen zur Behandlung von Folgen des Alkoholmissbrauchs, Hepatitis, Pankreatitis, Alzheimererkrankung, Morbus Parkinson, Diabetes, toxischen Nierenerkrankungen, Reperfusionsschäden, der Arteriosklerose sowie als Antidote gegen Umweltgifte und Medikamentenintoxikation |
EP1828192B1 (en) | 2004-12-21 | 2014-12-03 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
ES2328626T3 (es) | 2005-03-31 | 2009-11-16 | Nycomed Gmbh | Derivados de imidazopiridina utiles como inhibidores de inos. |
US7704990B2 (en) | 2005-08-25 | 2010-04-27 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
WO2007033265A1 (en) * | 2005-09-14 | 2007-03-22 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors for treating diabetis |
RS52110B2 (sr) | 2005-09-14 | 2018-05-31 | Takeda Pharmaceuticals Co | Inhibitori dipeptidil peptidaze za lečenje dijabetesa |
JP5122462B2 (ja) | 2005-09-16 | 2013-01-16 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼ阻害剤 |
WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
WO2008031788A1 (en) * | 2006-09-12 | 2008-03-20 | Nycomed Gmbh | Aminoazepine derivatives as highly efficient inhibitors of the inducible nitric oxide synthase |
EA017799B1 (ru) * | 2006-09-13 | 2013-03-29 | Такеда Фармасьютикал Компани Лимитед | Применение 2-[6-(3-аминопиперидин-1-ил)-3-метил-2,4-диоксо-3,4-дигидро-2н-пиримидин-1-илметил]-4-фторбензонитрила |
US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
Family Cites Families (6)
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JP2648897B2 (ja) | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
RU2136661C1 (ru) * | 1993-10-21 | 1999-09-10 | Джи Ди Сирл энд Ко. | Амидинопроизводные, их применение и фармацевтическая композиция |
US5994391A (en) | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
WO1996033175A1 (en) * | 1995-04-20 | 1996-10-24 | G.D. Searle & Co. | Cyclic amidino agents useful as nitric oxide synthase inhibitors |
GB9516709D0 (en) | 1995-08-15 | 1995-10-18 | Zeneca Ltd | Medicament |
JP2002517502A (ja) | 1998-06-10 | 2002-06-18 | ジー・ディー・サール・アンド・カンパニー | 複素二環状及び三環状一酸化窒素シンターゼ阻害剤 |
-
2001
- 2001-08-01 AU AU2001281083A patent/AU2001281083A1/en not_active Abandoned
- 2001-08-01 MX MXPA03000772A patent/MXPA03000772A/es unknown
- 2001-08-01 JP JP2002516271A patent/JP2004512271A/ja not_active Withdrawn
- 2001-08-01 EP EP01959537A patent/EP1305293A1/en not_active Withdrawn
- 2001-08-01 WO PCT/US2001/024542 patent/WO2002010139A1/en not_active Application Discontinuation
- 2001-08-01 CA CA002415851A patent/CA2415851A1/en not_active Abandoned
- 2001-08-01 EA EA200300030A patent/EA005817B1/ru not_active IP Right Cessation
- 2001-08-01 AR ARP010103682A patent/AR032360A1/es unknown
- 2001-08-01 NZ NZ523770A patent/NZ523770A/en unknown
- 2001-08-01 US US09/920,612 patent/US6495544B2/en not_active Expired - Fee Related
- 2001-10-09 PE PE2001000771A patent/PE20030413A1/es not_active Application Discontinuation
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JP2004512271A (ja) | 2004-04-22 |
WO2002010139A1 (en) | 2002-02-07 |
NZ523770A (en) | 2004-11-26 |
AU2001281083A1 (en) | 2002-02-13 |
EA200300030A1 (ru) | 2003-08-28 |
PE20030413A1 (es) | 2003-05-20 |
MXPA03000772A (es) | 2003-06-04 |
EA005817B1 (ru) | 2005-06-30 |
EP1305293A1 (en) | 2003-05-02 |
US6495544B2 (en) | 2002-12-17 |
US20020119964A1 (en) | 2002-08-29 |
CA2415851A1 (en) | 2002-02-07 |
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