EA200001122A1 - Ингибиторы синтазы оксида азота - Google Patents

Ингибиторы синтазы оксида азота

Info

Publication number
EA200001122A1
EA200001122A1 EA200001122A EA200001122A EA200001122A1 EA 200001122 A1 EA200001122 A1 EA 200001122A1 EA 200001122 A EA200001122 A EA 200001122A EA 200001122 A EA200001122 A EA 200001122A EA 200001122 A1 EA200001122 A1 EA 200001122A1
Authority
EA
Eurasian Patent Office
Prior art keywords
oxide synthase
nitrogen oxide
synthase inhibitors
ccycloalkyl
solvate
Prior art date
Application number
EA200001122A
Other languages
English (en)
Other versions
EA003026B1 (ru
Inventor
Пол Джон Бесуик
Сэввас Клинтхаус
Роберт Джон Янг
Original Assignee
Глаксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Глаксо Груп Лимитед filed Critical Глаксо Груп Лимитед
Publication of EA200001122A1 publication Critical patent/EA200001122A1/ru
Publication of EA003026B1 publication Critical patent/EA003026B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Настоящее изобретение относится к новым амидиносоединениям формулы (I) или их соли, сольвату или физиологически функциональному производному, где Rвыбран из Cалкила, Cциклоалкила, Cгидроксиалкила и Cгалогеноалкила, способу их получения, содержащим их фармацевтическим композициям и их применению в терапии, в частности их применению в качестве селективных ингибиторов индуцибельной синтазы оксида азота.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200001122A 1998-05-30 1999-05-27 Ингибиторы синтазы оксида азота EA003026B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9811599.1A GB9811599D0 (en) 1998-05-30 1998-05-30 Nitric oxide synthase inhibitors
PCT/EP1999/003583 WO1999062875A1 (en) 1998-05-30 1999-05-27 Nitric oxide synthase inhibitors

Publications (2)

Publication Number Publication Date
EA200001122A1 true EA200001122A1 (ru) 2001-06-25
EA003026B1 EA003026B1 (ru) 2002-12-26

Family

ID=10832929

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200001122A EA003026B1 (ru) 1998-05-30 1999-05-27 Ингибиторы синтазы оксида азота

Country Status (31)

Country Link
US (2) US6355689B1 (ru)
EP (1) EP1084104B1 (ru)
JP (1) JP3839256B2 (ru)
KR (1) KR20010043920A (ru)
CN (1) CN1218940C (ru)
AP (1) AP1382A (ru)
AT (1) ATE245142T1 (ru)
AU (1) AU757042B2 (ru)
BR (1) BR9910849A (ru)
CA (1) CA2333322C (ru)
CZ (1) CZ297473B6 (ru)
DE (1) DE69909625T2 (ru)
DK (1) DK1084104T3 (ru)
EA (1) EA003026B1 (ru)
EE (1) EE04149B1 (ru)
ES (1) ES2203147T3 (ru)
GB (1) GB9811599D0 (ru)
HK (1) HK1034241A1 (ru)
HU (1) HUP0102472A3 (ru)
ID (1) ID26790A (ru)
IL (1) IL139697A (ru)
IS (1) IS2442B (ru)
NO (1) NO20006044L (ru)
NZ (1) NZ508222A (ru)
PL (1) PL194784B1 (ru)
PT (1) PT1084104E (ru)
RS (1) RS49984B (ru)
SK (1) SK18052000A3 (ru)
TR (1) TR200003539T2 (ru)
WO (1) WO1999062875A1 (ru)
ZA (1) ZA200006847B (ru)

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CA2333322A1 (en) 1999-12-09
CN1303367A (zh) 2001-07-11
JP2002516901A (ja) 2002-06-11
CN1218940C (zh) 2005-09-14
GB9811599D0 (en) 1998-07-29
IS5723A (is) 2000-11-21
HUP0102472A2 (hu) 2002-03-28
ES2203147T3 (es) 2004-04-01
ZA200006847B (en) 2001-11-22
RS49984B (sr) 2008-09-29
EE200000716A (et) 2002-04-15
HK1034241A1 (en) 2001-10-19
DE69909625D1 (en) 2003-08-21
DE69909625T2 (de) 2004-06-24
BR9910849A (pt) 2001-02-20
EE04149B1 (et) 2003-10-15
PT1084104E (pt) 2003-11-28
IL139697A0 (en) 2002-02-10
AP1382A (en) 2005-04-01
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AU757042B2 (en) 2003-01-30
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ID26790A (id) 2001-02-08
NO20006044L (no) 2001-01-29
IL139697A (en) 2005-12-18
PL194784B1 (pl) 2007-07-31
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EA003026B1 (ru) 2002-12-26
AU4367199A (en) 1999-12-20
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