MXPA03002271A - Derivados de acido 2-amino-2-alquil-3-hexenoico y 2-amino-2-alquil-3-hexinoico utiles como inhibidores de oxido nitrico sintasa. - Google Patents

Derivados de acido 2-amino-2-alquil-3-hexenoico y 2-amino-2-alquil-3-hexinoico utiles como inhibidores de oxido nitrico sintasa.

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Publication number
MXPA03002271A
MXPA03002271A MXPA03002271A MXPA03002271A MXPA03002271A MX PA03002271 A MXPA03002271 A MX PA03002271A MX PA03002271 A MXPA03002271 A MX PA03002271A MX PA03002271 A MXPA03002271 A MX PA03002271A MX PA03002271 A MXPA03002271 A MX PA03002271A
Authority
MX
Mexico
Prior art keywords
hexenoic
amino
alkyl
acid derivatives
nitric oxide
Prior art date
Application number
MXPA03002271A
Other languages
English (en)
Inventor
Barnett S Pitzele
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of MXPA03002271A publication Critical patent/MXPA03002271A/es

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/30—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same unsaturated acyclic carbon skeleton
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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    • C07B2200/09—Geometrical isomers

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  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurology (AREA)
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  • Diabetes (AREA)
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  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
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  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
MXPA03002271A 2000-09-15 2001-09-15 Derivados de acido 2-amino-2-alquil-3-hexenoico y 2-amino-2-alquil-3-hexinoico utiles como inhibidores de oxido nitrico sintasa. MXPA03002271A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23281600P 2000-09-15 2000-09-15
PCT/US2001/028505 WO2002022561A1 (en) 2000-09-15 2001-09-15 2-amino-2-alkyl-3 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors

Publications (1)

Publication Number Publication Date
MXPA03002271A true MXPA03002271A (es) 2003-06-06

Family

ID=22874718

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03002271A MXPA03002271A (es) 2000-09-15 2001-09-15 Derivados de acido 2-amino-2-alquil-3-hexenoico y 2-amino-2-alquil-3-hexinoico utiles como inhibidores de oxido nitrico sintasa.

Country Status (9)

Country Link
US (1) US6828456B2 (es)
EP (1) EP1317420A1 (es)
JP (1) JP2004509098A (es)
AR (1) AR031608A1 (es)
AU (1) AU2001290812A1 (es)
CA (1) CA2420450A1 (es)
MX (1) MXPA03002271A (es)
NZ (1) NZ524558A (es)
WO (1) WO2002022561A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7879840B2 (en) 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7718644B2 (en) 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
JP2007525165A (ja) 2003-03-07 2007-09-06 トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク タイプ１ライアノジン受容体に基づく方法
ES2363001T3 (es) * 2003-03-11 2011-07-18 Pharmacia Corporation Sal cristalina de clorhidrato de maleato de s-[2(1-iminoetil)etil]-2-metil-l-cisteina.
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
US7704990B2 (en) 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US20090215687A1 (en) 2005-10-21 2009-08-27 Cornell Research Foundation, Inc. Compounds for Enhancing Hypoxia Inducible Factor Activity and Methods of Use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5132453A (en) 1991-03-22 1992-07-21 Cornell Research Foundation, Inc. N6 -(hydrazinoiminomethyl)lysine and method of inhibiting nitric oxide formation in body
GB9127376D0 (en) * 1991-12-24 1992-02-19 Wellcome Found Amidino derivatives
US5281627A (en) * 1992-05-28 1994-01-25 Cornell Research Foundation, Inc. Substituted arginines and substituted homoarginines and use thereof
AU2190895A (en) 1994-03-24 1995-10-09 G.D. Searle & Co. Amidino derivatives useful as nitric oxide synthase inhibitors
CA2322873A1 (en) * 1998-03-11 1999-09-16 G.D. Searle & Co. Halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors

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AU2001290812A1 (en) 2002-03-26
WO2002022561A1 (en) 2002-03-21
US6828456B2 (en) 2004-12-07
NZ524558A (en) 2005-02-25
AR031608A1 (es) 2003-09-24
EP1317420A1 (en) 2003-06-11
JP2004509098A (ja) 2004-03-25
US20020072631A1 (en) 2002-06-13
CA2420450A1 (en) 2002-03-21

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