CA2553035A1 - Modified human growth hormone polypeptides and their uses - Google Patents

Modified human growth hormone polypeptides and their uses Download PDF

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Publication number
CA2553035A1
CA2553035A1 CA002553035A CA2553035A CA2553035A1 CA 2553035 A1 CA2553035 A1 CA 2553035A1 CA 002553035 A CA002553035 A CA 002553035A CA 2553035 A CA2553035 A CA 2553035A CA 2553035 A1 CA2553035 A1 CA 2553035A1
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CA
Canada
Prior art keywords
amino acid
hgh polypeptide
polypeptide
group
hgh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002553035A
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English (en)
French (fr)
Inventor
Ho Sung Cho
Thomas Daniel
Richard Dimarchi
Anna-Maria A. Hays Putnam
Troy Wilson
Bee-Cheng Sim
David Litzinger
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Ambrx Inc
Original Assignee
Individual
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Filing date
Publication date
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Publication of CA2553035A1 publication Critical patent/CA2553035A1/en
Abandoned legal-status Critical Current

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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
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    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
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    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
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    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33396—Polymers modified by chemical after-treatment with organic compounds containing nitrogen having oxygen in addition to nitrogen
    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/6875—Nucleoproteins
    • G—PHYSICS
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
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CA002553035A 2004-02-02 2005-01-28 Modified human growth hormone polypeptides and their uses Abandoned CA2553035A1 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US54152804P 2004-02-02 2004-02-02
US60/541,528 2004-02-02
US58131404P 2004-06-18 2004-06-18
US58117504P 2004-06-18 2004-06-18
US58088504P 2004-06-18 2004-06-18
US60/581,314 2004-06-18
US60/581,175 2004-06-18
US60/580,885 2004-06-18
US63861604P 2004-12-22 2004-12-22
US60/638,616 2004-12-22
PCT/US2005/002724 WO2005074546A2 (en) 2004-02-02 2005-01-28 Modified human growth hormone polypeptides and their uses

Publications (1)

Publication Number Publication Date
CA2553035A1 true CA2553035A1 (en) 2005-08-18

Family

ID=34842043

Family Applications (3)

Application Number Title Priority Date Filing Date
CA002553035A Abandoned CA2553035A1 (en) 2004-02-02 2005-01-28 Modified human growth hormone polypeptides and their uses
CA002553040A Abandoned CA2553040A1 (en) 2004-02-02 2005-01-28 Modified human four helical bundle polypeptides and their uses
CA002553034A Abandoned CA2553034A1 (en) 2004-02-02 2005-01-28 Modified human interferon polypeptides and their uses

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA002553040A Abandoned CA2553040A1 (en) 2004-02-02 2005-01-28 Modified human four helical bundle polypeptides and their uses
CA002553034A Abandoned CA2553034A1 (en) 2004-02-02 2005-01-28 Modified human interferon polypeptides and their uses

Country Status (15)

Country Link
US (15) US8119603B2 (enExample)
EP (4) EP1740608B1 (enExample)
JP (3) JP2007519422A (enExample)
KR (3) KR20060130182A (enExample)
CN (1) CN103755800B (enExample)
AT (1) ATE546463T1 (enExample)
AU (5) AU2005209926B2 (enExample)
BR (3) BRPI0507169A (enExample)
CA (3) CA2553035A1 (enExample)
GB (3) GB2429207A (enExample)
IL (3) IL176596A0 (enExample)
MX (3) MXPA06008496A (enExample)
NZ (4) NZ548257A (enExample)
SG (1) SG135176A1 (enExample)
WO (3) WO2005074524A2 (enExample)

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US7611700B2 (en) * 2002-09-09 2009-11-03 Hanall Pharmaceuticals, Co., Ltd. Protease resistant modified interferon alpha polypeptides
US20070105770A1 (en) * 2004-01-21 2007-05-10 Novo Nordisk A/S Transglutaminase mediated conjugation of peptides
BRPI0507169A (pt) * 2004-02-02 2007-06-26 Ambrx Inc polipeptìdeos do hormÈnio de crescimento humano modificados e seu usos
EP1584680A1 (en) * 2004-04-08 2005-10-12 Boehringer Ingelheim Austria GmbH Fed-batch fermentation process for the production of plasmid DNA
US20050287639A1 (en) 2004-05-17 2005-12-29 California Institute Of Technology Methods of incorporating amino acid analogs into proteins
MXPA06014684A (es) 2004-06-18 2007-02-12 Ambrx Inc Novedosos polipeptidos de enlace antigeno y sus usos.
WO2006091231A2 (en) 2004-07-21 2006-08-31 Ambrx, Inc. Biosynthetic polypeptides utilizing non-naturally encoded amino acids
EP1805217A2 (en) * 2004-10-18 2007-07-11 Novo Nordisk A/S Method for the preparation of oxime, thiazolidine, dithiane, dithiolane or hydrazone linked analogues of growth hormone
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
EP2325206B1 (en) 2004-11-12 2014-03-19 Xencor, Inc. Fc variants with altered binding to fcrn
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