IT1222427B - Procedimento per la purificazione di interferone - Google Patents
Procedimento per la purificazione di interferoneInfo
- Publication number
- IT1222427B IT1222427B IT21560/87A IT2156087A IT1222427B IT 1222427 B IT1222427 B IT 1222427B IT 21560/87 A IT21560/87 A IT 21560/87A IT 2156087 A IT2156087 A IT 2156087A IT 1222427 B IT1222427 B IT 1222427B
- Authority
- IT
- Italy
- Prior art keywords
- interferon
- aqueous solution
- column
- crude
- pyrogenic
- Prior art date
Links
- 238000000746 purification Methods 0.000 title abstract 2
- 102000014150 Interferons Human genes 0.000 abstract 7
- 108010050904 Interferons Proteins 0.000 abstract 7
- 229940079322 interferon Drugs 0.000 abstract 7
- 239000007864 aqueous solution Substances 0.000 abstract 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 239000008367 deionised water Substances 0.000 abstract 2
- 238000010828 elution Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000001698 pyrogenic effect Effects 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT21560/87A IT1222427B (it) | 1987-07-31 | 1987-07-31 | Procedimento per la purificazione di interferone |
| EP88111201A EP0301314B1 (en) | 1987-07-31 | 1988-07-13 | A method for the purification of interferon |
| DE88111201T DE3886118T2 (de) | 1987-07-31 | 1988-07-13 | Methode zur Reinigung von Interferon. |
| AT88111201T ATE98257T1 (de) | 1987-07-31 | 1988-07-13 | Methode zur reinigung von interferon. |
| ES88111201T ES2046999T3 (es) | 1987-07-31 | 1988-07-13 | Un metodo para la purificacion de interferon. |
| US07/220,312 US5066786A (en) | 1987-07-31 | 1988-07-18 | Method for the purification of interferon |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT21560/87A IT1222427B (it) | 1987-07-31 | 1987-07-31 | Procedimento per la purificazione di interferone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8721560A0 IT8721560A0 (it) | 1987-07-31 |
| IT1222427B true IT1222427B (it) | 1990-09-05 |
Family
ID=11183608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT21560/87A IT1222427B (it) | 1987-07-31 | 1987-07-31 | Procedimento per la purificazione di interferone |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5066786A (it) |
| EP (1) | EP0301314B1 (it) |
| AT (1) | ATE98257T1 (it) |
| DE (1) | DE3886118T2 (it) |
| ES (1) | ES2046999T3 (it) |
| IT (1) | IT1222427B (it) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1240612B (it) * | 1990-03-16 | 1993-12-17 | Sclavo Spa | Procedimento di purificazione del b-interferone umano ricombinante |
| EP0551535A1 (en) * | 1992-01-13 | 1993-07-21 | SCLAVO S.p.A. | Process for the purification of recombinant human beta interferon, beta interferon thus purified, and pharmaceutical compositions which contain them |
| EP0626448A3 (de) * | 1993-05-26 | 1998-01-14 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Verfahren zur Herstellung und Reinigung von alpha-Interferon |
| WO2002038170A2 (en) * | 2000-11-07 | 2002-05-16 | Chiron Corporation | Stabilized inteferon compositions |
| KR100524871B1 (ko) * | 2003-12-04 | 2005-10-31 | 씨제이 주식회사 | 인터페론 베타의 정제방법 |
| KR100524872B1 (ko) * | 2003-12-04 | 2005-11-01 | 씨제이 주식회사 | 인터페론 베타의 정제방법 |
| US8778880B2 (en) | 2004-02-02 | 2014-07-15 | Ambrx, Inc. | Human growth hormone modified at position 35 |
| RU2473696C1 (ru) * | 2011-07-14 | 2013-01-27 | Закрытое акционерное общество "ГЕНЕРИУМ" | ПРОМЫШЛЕННЫЙ СПОСОБ ПОЛУЧЕНИЯ И ОЧИСТКИ РЕКОМБИНАНТНОГО ИНТЕРФЕРОНА β-1b ЧЕЛОВЕКА ИЗ ТЕЛЕЦ ВКЛЮЧЕНИЯ |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3897309A (en) * | 1974-02-15 | 1975-07-29 | Merck & Co Inc | Process for removing pyrogenic material from aqueous solutions |
| NL7605805A (nl) * | 1976-05-28 | 1977-11-30 | Stichting Rega V Z W | Werkwijze voor het zuiveren van interferon. |
| NL7907791A (nl) * | 1979-10-23 | 1981-04-27 | Stichting Rega V Z W | Werkwijze voor het zuiveren van interferon. |
| US4485038A (en) * | 1982-10-19 | 1984-11-27 | Health Research (Roswell Park Division) | Method for the production and purification of human leukocyte interferon |
| US4485017A (en) * | 1982-12-22 | 1984-11-27 | Cetus Corporation | Isolation of human interferon by immunosorbent and high performance liquid chromatography |
| IL67896A (en) * | 1983-02-13 | 1987-03-31 | Yeda Res & Dev | Two biologically active human gama interferon subtypes,purification thereof and pharmaceutical compositions containing them |
| US4894330A (en) * | 1986-12-23 | 1990-01-16 | Cetus Corporation | Purification of recombinant beta-interferon incorporating RP-HPLC |
-
1987
- 1987-07-31 IT IT21560/87A patent/IT1222427B/it active
-
1988
- 1988-07-13 ES ES88111201T patent/ES2046999T3/es not_active Expired - Lifetime
- 1988-07-13 EP EP88111201A patent/EP0301314B1/en not_active Expired - Lifetime
- 1988-07-13 AT AT88111201T patent/ATE98257T1/de not_active IP Right Cessation
- 1988-07-13 DE DE88111201T patent/DE3886118T2/de not_active Expired - Fee Related
- 1988-07-18 US US07/220,312 patent/US5066786A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IT8721560A0 (it) | 1987-07-31 |
| US5066786A (en) | 1991-11-19 |
| EP0301314A3 (en) | 1990-05-30 |
| EP0301314A2 (en) | 1989-02-01 |
| DE3886118D1 (de) | 1994-01-20 |
| EP0301314B1 (en) | 1993-12-08 |
| ATE98257T1 (de) | 1993-12-15 |
| ES2046999T3 (es) | 1994-02-16 |
| DE3886118T2 (de) | 1994-04-07 |
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