DE3886118T2 - Methode zur Reinigung von Interferon. - Google Patents

Methode zur Reinigung von Interferon.

Info

Publication number
DE3886118T2
DE3886118T2 DE88111201T DE3886118T DE3886118T2 DE 3886118 T2 DE3886118 T2 DE 3886118T2 DE 88111201 T DE88111201 T DE 88111201T DE 3886118 T DE3886118 T DE 3886118T DE 3886118 T2 DE3886118 T2 DE 3886118T2
Authority
DE
Germany
Prior art keywords
interferon
aqueous solution
column
crude
pyrogenic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88111201T
Other languages
English (en)
Other versions
DE3886118D1 (de
Inventor
Otello Protasi
Paolo Rappuoli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sclavo SpA
Original Assignee
Sclavo SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sclavo SpA filed Critical Sclavo SpA
Publication of DE3886118D1 publication Critical patent/DE3886118D1/de
Application granted granted Critical
Publication of DE3886118T2 publication Critical patent/DE3886118T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE88111201T 1987-07-31 1988-07-13 Methode zur Reinigung von Interferon. Expired - Fee Related DE3886118T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21560/87A IT1222427B (it) 1987-07-31 1987-07-31 Procedimento per la purificazione di interferone

Publications (2)

Publication Number Publication Date
DE3886118D1 DE3886118D1 (de) 1994-01-20
DE3886118T2 true DE3886118T2 (de) 1994-04-07

Family

ID=11183608

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88111201T Expired - Fee Related DE3886118T2 (de) 1987-07-31 1988-07-13 Methode zur Reinigung von Interferon.

Country Status (6)

Country Link
US (1) US5066786A (de)
EP (1) EP0301314B1 (de)
AT (1) ATE98257T1 (de)
DE (1) DE3886118T2 (de)
ES (1) ES2046999T3 (de)
IT (1) IT1222427B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1240612B (it) * 1990-03-16 1993-12-17 Sclavo Spa Procedimento di purificazione del b-interferone umano ricombinante
EP0551535A1 (de) * 1992-01-13 1993-07-21 SCLAVO S.p.A. Verfahren zur Reinigung von rekombinant-menschlichem Interferon-Beta, dadurch gereinigtes Interferon-Beta und pharmazeutische Zusammensetzungen, die diese enthalten
EP0626448A3 (de) * 1993-05-26 1998-01-14 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Verfahren zur Herstellung und Reinigung von alpha-Interferon
CA2428144C (en) * 2000-11-07 2012-01-10 Chiron Corporation Compositions of interferon-beta stabilized with highly purified mannitol
KR100524871B1 (ko) * 2003-12-04 2005-10-31 씨제이 주식회사 인터페론 베타의 정제방법
KR100524872B1 (ko) * 2003-12-04 2005-11-01 씨제이 주식회사 인터페론 베타의 정제방법
US8778880B2 (en) 2004-02-02 2014-07-15 Ambrx, Inc. Human growth hormone modified at position 35
RU2473696C1 (ru) * 2011-07-14 2013-01-27 Закрытое акционерное общество "ГЕНЕРИУМ" ПРОМЫШЛЕННЫЙ СПОСОБ ПОЛУЧЕНИЯ И ОЧИСТКИ РЕКОМБИНАНТНОГО ИНТЕРФЕРОНА β-1b ЧЕЛОВЕКА ИЗ ТЕЛЕЦ ВКЛЮЧЕНИЯ

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3897309A (en) * 1974-02-15 1975-07-29 Merck & Co Inc Process for removing pyrogenic material from aqueous solutions
NL7605805A (nl) * 1976-05-28 1977-11-30 Stichting Rega V Z W Werkwijze voor het zuiveren van interferon.
NL7907791A (nl) * 1979-10-23 1981-04-27 Stichting Rega V Z W Werkwijze voor het zuiveren van interferon.
US4485038A (en) * 1982-10-19 1984-11-27 Health Research (Roswell Park Division) Method for the production and purification of human leukocyte interferon
US4485017A (en) * 1982-12-22 1984-11-27 Cetus Corporation Isolation of human interferon by immunosorbent and high performance liquid chromatography
IL67896A (en) * 1983-02-13 1987-03-31 Yeda Res & Dev Two biologically active human gama interferon subtypes,purification thereof and pharmaceutical compositions containing them
US4894330A (en) * 1986-12-23 1990-01-16 Cetus Corporation Purification of recombinant beta-interferon incorporating RP-HPLC

Also Published As

Publication number Publication date
ATE98257T1 (de) 1993-12-15
EP0301314B1 (de) 1993-12-08
IT8721560A0 (it) 1987-07-31
US5066786A (en) 1991-11-19
DE3886118D1 (de) 1994-01-20
EP0301314A2 (de) 1989-02-01
ES2046999T3 (es) 1994-02-16
EP0301314A3 (en) 1990-05-30
IT1222427B (it) 1990-09-05

Similar Documents

Publication Publication Date Title
DE59409712D1 (de) Verfahren zur chromatographischen reinigung und trennung von nucleinsäuregemischen
DK0391526T3 (da) Antistofoprensningsfremgangsmåde
DE3578613D1 (de) Verfahren zur reinigung des influenzavirus.
DE3578839D1 (de) Verfahren zur reinigung des japanischen enzephalitisvirus.
DE3886118T2 (de) Methode zur Reinigung von Interferon.
DE3853610T2 (de) Verfahren zur Proteinreinigung.
ATE96784T1 (de) Verfahren zur reinigung von tryptophan.
DE69010442T2 (de) Reinigung von 1,1-Dichlor-1-fluorethan.
DE3788170T2 (de) Methode zur Reinigung und Isolierung von zwei ionischen Formen von Somatomedin.
DE68919282D1 (de) Verfahren zur Herstellung von Cephalosporin und Zwischenverbindungen.
DE68928634D1 (de) Verfahren zur Herstellung von aktivierten Killer-Monozyten und Verfahren zur Überprüfung ihrer tumoriziden Aktivität
ATE44750T1 (de) Verfahren zur herstellung eines antihaemophiliefaktor-konzentrats.
DE3881888D1 (de) Herstellung von reinem titantetrachlorid und titantetrachlorid-loesungen.
DE59209053D1 (de) Verfahren zur Herstellung aktivierter Sialinsäuren
ATE88188T1 (de) Verfahren zur herstellung von antihaemophilem faktor (faktor viii), der eine hohe reinheit aufweist.
ATE73756T1 (de) Verfahren zur reinigung von alpha-substituierten essigsaeuren.
ATE132166T1 (de) Verfahren zum umsetzen von fusionsprotein in aktiven menschlichen motiunähnlichen polypeptiden und reinigung von diesen analogen
DE69606959D1 (de) Verfahren zur Herstellung von Plättchen-Faktor-4
ATE13633T1 (de) Verfahren zur herstellung von hochgereinigtem antihaemophiliefaktor.
Sinyak et al. Sanitary-Hygienic Evaluation of the Extraction Method of Water Regeneration from Atmospheric Moisture,(In Russian)
ATE90658T1 (de) Verfahren zur reinigung von dhydroxyphenoxypropions|ure.
DE3886172D1 (de) Verfahren zur Herstellung von Peptidsynthonen.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee