CA2072945C - Pyrimidine derivatives - Google Patents

Pyrimidine derivatives Download PDF

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Publication number
CA2072945C
CA2072945C CA002072945A CA2072945A CA2072945C CA 2072945 C CA2072945 C CA 2072945C CA 002072945 A CA002072945 A CA 002072945A CA 2072945 A CA2072945 A CA 2072945A CA 2072945 C CA2072945 C CA 2072945C
Authority
CA
Canada
Prior art keywords
compound
methyl
isopropyl
fluorophenyl
pyrimidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002072945A
Other languages
English (en)
French (fr)
Other versions
CA2072945A1 (en
Inventor
Kentaro Hirai
Teruyuki Ishiba
Haruo Koike
Masamichi Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16216169&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2072945(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of CA2072945A1 publication Critical patent/CA2072945A1/en
Application granted granted Critical
Publication of CA2072945C publication Critical patent/CA2072945C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/38—One sulfur atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002072945A 1991-07-01 1992-07-02 Pyrimidine derivatives Expired - Lifetime CA2072945C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP18801591 1991-07-01
JP188015/1991 1991-07-01

Publications (2)

Publication Number Publication Date
CA2072945A1 CA2072945A1 (en) 1993-01-02
CA2072945C true CA2072945C (en) 2001-07-31

Family

ID=16216169

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002072945A Expired - Lifetime CA2072945C (en) 1991-07-01 1992-07-02 Pyrimidine derivatives

Country Status (18)

Country Link
US (2) US5260440A (enExample)
EP (1) EP0521471B1 (enExample)
JP (1) JP2648897B2 (enExample)
KR (1) KR960005951B1 (enExample)
AT (1) ATE197149T1 (enExample)
CA (1) CA2072945C (enExample)
CL (1) CL2010000113A1 (enExample)
CY (2) CY2226B1 (enExample)
DE (2) DE122009000017I2 (enExample)
DK (1) DK0521471T3 (enExample)
ES (1) ES2153824T3 (enExample)
GE (1) GEP20022693B (enExample)
GR (1) GR3035189T3 (enExample)
HU (2) HU220624B1 (enExample)
LU (1) LU91042I2 (enExample)
NL (1) NL300125I2 (enExample)
PT (1) PT521471E (enExample)
TW (1) TW203044B (enExample)

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DE122009000017I2 (de) 2010-10-21
HU0004863D0 (enExample) 2001-02-28
CY2004008I2 (el) 2016-10-05
CL2010000113A1 (es) 2010-07-02
JP2648897B2 (ja) 1997-09-03
NL300125I2 (nl) 2003-08-01
NL300125I1 (nl) 2003-07-01
DE69231530D1 (de) 2000-11-30
PT521471E (pt) 2001-04-30
GR3035189T3 (en) 2001-04-30
LU91042I2 (fr) 2003-11-24
DK0521471T3 (da) 2001-02-05
EP0521471B1 (en) 2000-10-25
DE122009000017I1 (de) 2009-11-05
JPH05178841A (ja) 1993-07-20
CY2004008I1 (el) 2010-07-28
CY2226B1 (en) 2003-04-18
HK1011986A1 (en) 1999-07-23
HU220624B1 (hu) 2002-03-28

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