BRPI0915878A2 - sais ou hidratos de compostos inibidores de hiv, seu uso e composição farmacêutica que os compreende - Google Patents

sais ou hidratos de compostos inibidores de hiv, seu uso e composição farmacêutica que os compreende

Info

Publication number
BRPI0915878A2
BRPI0915878A2 BRPI0915878A BRPI0915878A BRPI0915878A2 BR PI0915878 A2 BRPI0915878 A2 BR PI0915878A2 BR PI0915878 A BRPI0915878 A BR PI0915878A BR PI0915878 A BRPI0915878 A BR PI0915878A BR PI0915878 A2 BRPI0915878 A2 BR PI0915878A2
Authority
BR
Brazil
Prior art keywords
hydrates
hiv
salts
pharmaceutical composition
inhibiting compounds
Prior art date
Application number
BRPI0915878A
Other languages
English (en)
Inventor
Benjamin R Graetz
Richard P Polniaszek
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of BRPI0915878A2 publication Critical patent/BRPI0915878A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BRPI0915878A 2008-07-08 2009-07-07 sais ou hidratos de compostos inibidores de hiv, seu uso e composição farmacêutica que os compreende BRPI0915878A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7898908P 2008-07-08 2008-07-08
PCT/US2009/049838 WO2010005986A1 (en) 2008-07-08 2009-07-07 Salts of hiv inhibitor compounds

Publications (1)

Publication Number Publication Date
BRPI0915878A2 true BRPI0915878A2 (pt) 2015-11-03

Family

ID=41055429

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0915878A BRPI0915878A2 (pt) 2008-07-08 2009-07-07 sais ou hidratos de compostos inibidores de hiv, seu uso e composição farmacêutica que os compreende

Country Status (27)

Country Link
US (6) US8658617B2 (pt)
EP (1) EP2307435B1 (pt)
JP (2) JP5620376B2 (pt)
KR (1) KR101642527B1 (pt)
CN (1) CN102089318B (pt)
AP (1) AP3347A (pt)
AU (1) AU2009268681B2 (pt)
BR (1) BRPI0915878A2 (pt)
CA (1) CA2729769C (pt)
CL (1) CL2011000014A1 (pt)
CO (1) CO6321288A2 (pt)
CY (1) CY1113240T1 (pt)
DK (1) DK2307435T3 (pt)
EA (1) EA018308B1 (pt)
EC (1) ECSP11010807A (pt)
ES (1) ES2393962T3 (pt)
HK (1) HK1156633A1 (pt)
HR (1) HRP20120700T1 (pt)
IL (1) IL210006A (pt)
MX (1) MX2011000306A (pt)
NZ (1) NZ590075A (pt)
PE (1) PE20110219A1 (pt)
PL (1) PL2307435T3 (pt)
PT (1) PT2307435E (pt)
UA (1) UA103329C2 (pt)
WO (1) WO2010005986A1 (pt)
ZA (1) ZA201100694B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE490788T1 (de) 2003-04-25 2010-12-15 Gilead Sciences Inc Antivirale phosphonate analoge
EP1778251B1 (en) * 2004-07-27 2011-04-13 Gilead Sciences, Inc. Nucleoside phosphonate conjugates as anti hiv agents
AU2009268681B2 (en) * 2008-07-08 2014-10-02 Gilead Sciences, Inc. Salts of HIV inhibitor compounds
WO2012138907A2 (en) * 2011-04-05 2012-10-11 Translational Genomics Research Institute Solid forms of curcumin
ES2700470T3 (es) * 2011-05-19 2019-02-15 Gilead Sciences Inc Procesos e intermediarios para la preparación de agentes anti-VIH
KR20170123308A (ko) 2014-12-26 2017-11-07 에모리 유니버시티 Ｎ4-하이드록시시티딘, 이와 관련된 유도체 및 이의 항 바이러스적 용도
EP3518935A1 (en) * 2016-09-27 2019-08-07 Gilead Sciences, Inc. Therapeutic compositions for treatment of human immunodeficiency virus
EP3960740B1 (en) * 2017-08-01 2023-11-15 Gilead Sciences, Inc. Crystalline forms of ethyl ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl)-l-alaninate (gs-9131) vanillate for treating viral infections
BR122022008466B1 (pt) 2017-12-07 2023-12-05 Emory University Uso de um composto

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CA2729769A1 (en) 2010-01-14
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US8658617B2 (en) 2014-02-25
US20140227224A1 (en) 2014-08-14
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US20100093667A1 (en) 2010-04-15
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