TNSN00027A1 - Inhibiteurs de l'aspartyle protease - Google Patents
Inhibiteurs de l'aspartyle proteaseInfo
- Publication number
- TNSN00027A1 TNSN00027A1 TNTNSN00027A TNSN00027A TNSN00027A1 TN SN00027 A1 TNSN00027 A1 TN SN00027A1 TN TNSN00027 A TNTNSN00027 A TN TNSN00027A TN SN00027 A TNSN00027 A TN SN00027A TN SN00027 A1 TNSN00027 A1 TN SN00027A1
- Authority
- TN
- Tunisia
- Prior art keywords
- hiv
- aspartyle
- compounds
- protease
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/42—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Abstract
LA PRESENTE INVENTION SE RAPPORTE A UNE NOUVELLE CLASSE DE SULFONAMIDES QUI SONT DES INHIBITEURS DE L'ASPARTYLE PROTEASE. DANS UNE REALISATION, CETTE INVENTION SE RAPPORTE A UNE NOUVELLE CLASSE D'INHIBITEURS DE L'ASPARTYLE PROTEASE DU HIV CARACTERISES PAR DES CARACTERISTIQUES STRUCTURELLES ET PHYSICO-CHIMIQUES SPECIFIQUES. CETTE INVENTION SE RAPPORTE AUSSI A DES COMPOSITIONS PHARMACEUTIQUES CONTENANT CES COMPOSES. LES COMPOSES ET LES COMPOSITIONS PHARMACEUTIQUES DE CETTE INVENTION SONT PARTICULIEREMENT BIEN ADAPTES A L'INHIBITION DE L'ACTIVITE DE LA PROTEASE DU HIV-1 ET DU HIV-2 ET PAR CONSEQUENT, ILS PEUVENT ETRE UTILISES AVANTAGEUSEMENT COMME AGENTS ANTIVIRAUX CONTRE LES VIRUS HIV-1 ET HIV-2. CETTE INVENTION SE RAPPORTE AUSSI A DES METHODES POUR INHIBER L'ACTIVITE DE L'ASPARTYLE PROTEASE DU HIV AU MOYEN DES COMPOSES DE CETTE INVENTION ET DES METHODES D'ANALYSE DE COMPOSES POUR METTRE EN EVIDENCE UNE ACTIVITE ANTI-HIV.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12004799P | 1999-02-12 | 1999-02-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
TNSN00027A1 true TNSN00027A1 (fr) | 2005-11-10 |
Family
ID=37874715
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNTNSN00027A TNSN00027A1 (fr) | 1999-02-12 | 2000-02-09 | Inhibiteurs de l'aspartyle protease |
Country Status (4)
Country | Link |
---|---|
US (4) | US6319946B1 (fr) |
CO (1) | CO5261510A1 (fr) |
TN (1) | TNSN00027A1 (fr) |
TW (1) | TWI260322B (fr) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040122000A1 (en) * | 1981-01-07 | 2004-06-24 | Vertex Pharmaceuticals Incorporated. | Inhibitors of aspartyl protease |
US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
TWI260322B (en) * | 1999-02-12 | 2006-08-21 | Vertex Pharma | Inhibitors of aspartyl protease |
AR037797A1 (es) * | 2001-12-12 | 2004-12-01 | Tibotec Pharm Ltd | Combinacion de inhibidores de proteasa dependientes del citocromo p450 |
WO2003057173A2 (fr) * | 2002-01-07 | 2003-07-17 | Sequoia Pharmaceuticals | Inhibiteurs polyvalents |
US7157489B2 (en) * | 2002-03-12 | 2007-01-02 | The Board Of Trustees Of The University Of Illinois | HIV protease inhibitors |
US20060128692A1 (en) * | 2002-04-26 | 2006-06-15 | Gilead Sciences, Inc | Non nucleoside reverse transcriptase inhibitors |
US20050261237A1 (en) * | 2003-04-25 | 2005-11-24 | Boojamra Constantine G | Nucleoside phosphonate analogs |
US7417055B2 (en) | 2003-04-25 | 2008-08-26 | Gilead Sciences, Inc. | Kinase inhibitory phosphonate analogs |
US7429565B2 (en) * | 2003-04-25 | 2008-09-30 | Gilead Sciences, Inc. | Antiviral phosphonate analogs |
WO2005002626A2 (fr) * | 2003-04-25 | 2005-01-13 | Gilead Sciences, Inc. | Composes de phosphonate therapeutiques |
WO2004096287A2 (fr) * | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Composes de phosphonate inhibiteurs de l'inosine monophosphate deshydrogenase |
US7407965B2 (en) * | 2003-04-25 | 2008-08-05 | Gilead Sciences, Inc. | Phosphonate analogs for treating metabolic diseases |
US7470724B2 (en) * | 2003-04-25 | 2008-12-30 | Gilead Sciences, Inc. | Phosphonate compounds having immuno-modulatory activity |
US7432261B2 (en) * | 2003-04-25 | 2008-10-07 | Gilead Sciences, Inc. | Anti-inflammatory phosphonate compounds |
US7452901B2 (en) | 2003-04-25 | 2008-11-18 | Gilead Sciences, Inc. | Anti-cancer phosphonate analogs |
WO2004096285A2 (fr) * | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Analogues anti-infectieux du phosphonate |
CN101410120A (zh) * | 2003-04-25 | 2009-04-15 | 吉里德科学公司 | 抗炎的膦酸酯化合物 |
US20090247488A1 (en) * | 2003-04-25 | 2009-10-01 | Carina Cannizzaro | Anti-inflammatory phosphonate compounds |
EP1638960A4 (fr) * | 2003-06-27 | 2009-04-01 | Smithkline Beecham Corp | Preparation de composes chimiques |
WO2005044279A1 (fr) * | 2003-10-24 | 2005-05-19 | Gilead Sciences, Inc. | Conjugues phosphonate / inhibiteur de purine nucleoside phosphorylase |
US7432273B2 (en) * | 2003-10-24 | 2008-10-07 | Gilead Sciences, Inc. | Phosphonate analogs of antimetabolites |
JP2007508843A (ja) * | 2003-10-24 | 2007-04-12 | ギリアード サイエンシーズ, インコーポレイテッド | 治療用化合物の同定のための方法および組成物 |
US20070281907A1 (en) * | 2003-12-22 | 2007-12-06 | Watkins William J | Kinase Inhibitor Phosphonate Conjugates |
WO2005063751A1 (fr) * | 2003-12-22 | 2005-07-14 | Gilead Sciences, Inc. | Derives de carbovir et d'abacavir 4'-substitues et composes associes dotes d'une activite antivirale dirigee contre le vih et le vhc |
US20050153990A1 (en) * | 2003-12-22 | 2005-07-14 | Watkins William J. | Phosphonate substituted kinase inhibitors |
MXPA06010365A (es) * | 2004-03-11 | 2007-05-04 | Sequoia Pharmaceuticals Inc | Inhibidores de proteasa retrovirales repelentes a la resistencia. |
CN1997363B (zh) | 2004-05-07 | 2012-03-28 | 塞阔伊亚药品公司 | 抗耐药性反转录病毒蛋白酶抑制剂 |
JP2008508291A (ja) | 2004-07-27 | 2008-03-21 | ギリアード サイエンシーズ, インコーポレイテッド | 抗hiv剤としてのヌクレオシドホスホネート結合体 |
CN101702908A (zh) * | 2007-03-23 | 2010-05-05 | 麻萨诸塞州大学 | Hiv-1蛋白酶抑制剂 |
CA2707161C (fr) | 2007-11-28 | 2016-08-16 | Sequoia Pharmaceuticals, Inc. | Compositions et procedes destines a l'inhibition du cytochrome p450 2d6 |
US8906647B2 (en) | 2008-02-21 | 2014-12-09 | Sequoia Pharmaceuticals, Inc. | Diamide inhibitors of cytochrome P450 |
WO2010005986A1 (fr) | 2008-07-08 | 2010-01-14 | Gilead Sciences, Inc. | Sels de composés inhibiteurs du vih |
MX360782B (es) | 2011-06-21 | 2018-11-16 | Alnylam Pharmaceuticals Inc | Composiciones de arni similares a angiopoyetina 3 (angptl3) y metodos para su uso. |
EP3597750B1 (fr) | 2011-06-23 | 2022-05-04 | Alnylam Pharmaceuticals, Inc. | Arnsi de serpina1 :compositions de matière et procédés de traitement |
JP2014520811A (ja) | 2011-06-29 | 2014-08-25 | ザ トラスティース オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク | 統合失調症の易罹病性及び認知機能障害と関連付けられるニューロン結合の阻害剤 |
US9127274B2 (en) | 2012-04-26 | 2015-09-08 | Alnylam Pharmaceuticals, Inc. | Serpinc1 iRNA compositions and methods of use thereof |
WO2014075093A1 (fr) * | 2012-11-09 | 2014-05-15 | The Trustees Of Columbia University In The City Of New York | Inhibiteurs du récepteur 2 de peptide inhibiteur vasoactif du système nerveux central |
ES2657608T3 (es) | 2012-12-05 | 2018-03-06 | Alnylam Pharmaceuticals, Inc. | Composiciones de arni de pcsk9 y métodos de uso de las mismas |
RS56663B1 (sr) | 2013-03-14 | 2018-03-30 | Alnylam Pharmaceuticals Inc | Irnk sastavi komponente komplementa c5 i metode za njihovu upotrebu |
SG10201804472YA (en) | 2013-05-22 | 2018-07-30 | Alnylam Pharmaceuticals Inc | SERPINA1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF |
AU2014268529C1 (en) | 2013-05-22 | 2020-10-01 | Alnylam Pharmaceuticals, Inc. | TMPRSS6 iRNA compositions and methods of use thereof |
CA3107872A1 (fr) | 2013-12-12 | 2015-06-18 | Alnylam Pharmaceuticals, Inc. | Composition d'arni d'element de complement et procedes pour les utiliser |
EP3960860A3 (fr) | 2014-02-11 | 2022-06-08 | Alnylam Pharmaceuticals, Inc. | Compositions d'arni de cétohexokinase (khk) et leurs procédés d'utilisation |
WO2015175510A1 (fr) | 2014-05-12 | 2015-11-19 | Alnylam Pharmaceuticals, Inc. | Méthodes et compositions pour le traitement d'un trouble associé à serpinc1 |
CN112852809A (zh) | 2014-05-22 | 2021-05-28 | 阿尔尼拉姆医药品有限公司 | 血管紧张素原(AGT)iRNA组合物及其使用方法 |
JPWO2016039403A1 (ja) * | 2014-09-11 | 2017-06-29 | 塩野義製薬株式会社 | 持続性hivプロテアーゼ阻害剤 |
EP3191591A1 (fr) | 2014-09-12 | 2017-07-19 | Alnylam Pharmaceuticals, Inc. | Agents polynucléotidiques ciblant le composant du complément c5 et leurs méthodes d'utilisation |
WO2016061487A1 (fr) | 2014-10-17 | 2016-04-21 | Alnylam Pharmaceuticals, Inc. | Agents polynucléotidiques de ciblage d'acide aminolévulinique synthase-1 (alas1) et utilisations de ceux-ci |
EP3904519A1 (fr) | 2014-10-30 | 2021-11-03 | Genzyme Corporation | Agents polynucléotidiques ciblant serpinc 1 (at3) et leurs méthodes d'utilisation |
CA2968114A1 (fr) | 2014-11-17 | 2016-05-26 | Alnylam Pharmaceuticals, Inc. | Compositions d'arni d'apolipoproteine c3 (apoc3) et procedes d'utilisation de ces compositions |
EP3256587A2 (fr) | 2015-02-13 | 2017-12-20 | Alnylam Pharmaceuticals, Inc. | Compositions d'arni du gène codant pour la protéine 3 contenant un domaine phospholipase de type patatine (pnpla3) et leurs procédés d'utilisation |
WO2016168286A1 (fr) | 2015-04-13 | 2016-10-20 | Alnylam Pharmaceuticals, Inc. | Compositions d'arni faisant intervenir la protéine 3 de type angiopoïétine (angptl3) et leurs procédés d'utilisation |
TWI727948B (zh) | 2015-05-06 | 2021-05-21 | 美商阿尼拉製藥公司 | 第十二因子(哈格曼因子)(F12)、激肽釋放素B、血漿(夫列契因子)1(KLKB1)及激肽原1(KNG1)iRNA組成物及其使用方法 |
EP3307316A1 (fr) | 2015-06-12 | 2018-04-18 | Alnylam Pharmaceuticals, Inc. | Compositions d'arni de composant du complément c5 et leurs procédés d'utilisation |
WO2016205323A1 (fr) | 2015-06-18 | 2016-12-22 | Alnylam Pharmaceuticals, Inc. | Agents polynucléotidiques ciblant l'hydroxyacide oxydase (glycolate oxydase, hao1) et procédés d'utilisation de ceux-ci |
EP3350328A1 (fr) | 2015-09-14 | 2018-07-25 | Alnylam Pharmaceuticals, Inc. | Agents de polynucléotide ciblant un domaine de phospholipase de type patatine contenant 3 (pnpla3) et leurs procédés d'utilisation |
SG11201804729RA (en) | 2015-12-07 | 2018-07-30 | Genzyme Corp | Methods and compositions for treating a serpinc1-associated disorder |
JP2018536689A (ja) | 2015-12-10 | 2018-12-13 | アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. | ステロール調節エレメント結合タンパク質(SREBP)シャペロン(SCAP)iRNA組成物およびその使用方法 |
EP3469083A1 (fr) | 2016-06-10 | 2019-04-17 | Alnylam Pharmaceuticals, Inc. | Compositions d'arni du composant c5 du complément et leurs méthodes d'utilisation pour traiter l'hémoglobinurie paroxystique nocturne (hpn) |
TWI788312B (zh) | 2016-11-23 | 2023-01-01 | 美商阿尼拉製藥公司 | 絲胺酸蛋白酶抑制因子A1 iRNA組成物及其使用方法 |
WO2018112320A1 (fr) | 2016-12-16 | 2018-06-21 | Alnylam Pharmaceuticals, Inc. | Méthodes de traitement ou de prévention de maladies associées à ttr à l'aide de compositions d'arni de transthyrétine (ttr) |
US11564921B2 (en) | 2017-07-21 | 2023-01-31 | Viiv Healthcare Company | Regimens for treating HIV infections and AIDS |
WO2019027920A1 (fr) | 2017-08-01 | 2019-02-07 | Gilead Sciences, Inc. | Formes cristallines d'éthyl ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)méthyl)(phénoxy)phosphoryl)-l-alaninate (gs-9131) pour le traitement d'infections virales |
WO2019089922A1 (fr) | 2017-11-01 | 2019-05-09 | Alnylam Pharmaceuticals, Inc. | Compositions d'arni de composant du complément c3 et leurs procédés d'utilisation |
AR114551A1 (es) | 2018-08-13 | 2020-09-16 | Alnylam Pharmaceuticals Inc | COMPOSICIONES DE AGENTES DE ARNhd CONTRA EL VIRUS DE HEPATITIS B (HBV) Y MÉTODOS PARA SU USO |
MX2021008628A (es) | 2019-01-16 | 2021-11-17 | Genzyme Corp | Composiciones de arni para serpinc1 y metodos de uso de las mismas. |
WO2021154941A1 (fr) | 2020-01-31 | 2021-08-05 | Alnylam Pharmaceuticals, Inc. | Compositions d'arni du composant c5 du complément destinées à être utilisées dans le traitement de la sclérose latérale amyotrophique (sla) |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4604402A (en) | 1984-03-30 | 1986-08-05 | E. R. Squibb & Sons, Inc. | Hydroxy substituted ureido amino and imino acids |
US4629724A (en) | 1984-12-03 | 1986-12-16 | E. R. Squibb & Sons, Inc. | Amino acid ester and amide renin inhibitors |
DK0656887T3 (da) | 1992-08-25 | 1999-07-05 | Searle & Co | Hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser |
US5723490A (en) | 1992-09-08 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | THF-containing sulfonamide inhibitors of aspartyl protease |
IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
TW372972B (en) | 1992-10-23 | 1999-11-01 | Novartis Ag | Antiretroviral acyl compounds |
ES2196436T3 (es) | 1992-10-30 | 2003-12-16 | Searle & Co | Acidos sulfonilalcanoilamino-hidroxietilamino-sulfamicos utiles como inhibidores de proteasas retrovirales. |
US5484926A (en) | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
DE69415326T2 (de) | 1993-08-24 | 1999-06-02 | Searle & Co | Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen |
IL110898A0 (en) | 1993-09-10 | 1994-11-28 | Narhex Australia Pty Ltd | Polar-substituted hydrocarbons |
IL111584A0 (en) | 1993-11-18 | 1995-01-24 | Merck & Co Inc | Prodrugs of an inhibitor of hiv protease and pharmaceutical compositions containing them |
US5527829A (en) | 1994-05-23 | 1996-06-18 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
DE69637380T2 (de) | 1995-01-20 | 2009-09-17 | G.D. Searle Llc, Chicago | Bis-sulfonamid-hydroxyethylamino-derivate als inhibitoren retroviraler proteasen |
US5691372A (en) * | 1995-04-19 | 1997-11-25 | Vertex Pharmaceuticals Incorporated | Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease |
TWI260322B (en) * | 1999-02-12 | 2006-08-21 | Vertex Pharma | Inhibitors of aspartyl protease |
-
2000
- 2000-02-09 TW TW089102108A patent/TWI260322B/zh not_active IP Right Cessation
- 2000-02-09 US US09/500,781 patent/US6319946B1/en not_active Expired - Lifetime
- 2000-02-09 TN TNTNSN00027A patent/TNSN00027A1/fr unknown
- 2000-02-09 CO CO00008433A patent/CO5261510A1/es not_active Application Discontinuation
-
2001
- 2001-08-09 US US09/927,271 patent/US6617350B2/en not_active Expired - Fee Related
-
2003
- 2003-07-02 US US10/613,650 patent/US7442718B2/en not_active Expired - Fee Related
-
2008
- 2008-07-02 US US12/217,517 patent/US7919523B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US6319946B1 (en) | 2001-11-20 |
TWI260322B (en) | 2006-08-21 |
US7442718B2 (en) | 2008-10-28 |
US20040127488A1 (en) | 2004-07-01 |
US7919523B2 (en) | 2011-04-05 |
US6617350B2 (en) | 2003-09-09 |
CO5261510A1 (es) | 2003-03-31 |
US20090042973A1 (en) | 2009-02-12 |
US20020198388A1 (en) | 2002-12-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TNSN00027A1 (fr) | Inhibiteurs de l'aspartyle protease | |
TNSN00129A1 (fr) | Inhibiteurs de l'aspartyle protease | |
AP1717A (en) | Sulfonamide inhibitors of aspartyl protease. | |
CA2217737A1 (fr) | Sulfamides contenant tetrahydrofurane (thf) et agissant comme inhibiteurs de la protease aspartyle | |
MY115797A (en) | Oxygenated-heterocycle containing sulfonamide inhibitors of aspartyl protease | |
MXPA03010538A (es) | Nuevas formulaciones que inhiben la proteasa aspartilo. | |
ATE237587T1 (de) | 11,15-o-dialkylprostaglandin-e-derivate, verfahren zu ihrer herstellung und arzneimittel, die diese als aktiven inhaltsstoff enthalten | |
IL112841A0 (en) | Sulfonamide aspartyl protease inhibitors methods for the preparation thereof and pharmaceutical compositions containing the same | |
HUP9903673A2 (hu) | A HIV CNS-hatásainak kezelése VX-478-cal önmagában vagy AZT-vel vagy 3TC-vel kombinációban | |
WO2000047551A3 (fr) | Inhibiteurs d'aspartyle protease | |
HUP0102813A2 (hu) | Perindopril-terc-butil-amin-só új béta-kristályos formája, eljárás ennek előállítására és ezt tartalmazó gyógyászati készítmények | |
NO974147D0 (no) | Heterocykelkarbonyl aminosyre hydroksyetylamino sulfonamid retroviral protease | |
DE69518840T2 (de) | N-(3-amino-2-hydroxybutyl)sulfonamid-derivate as hiv-protease-inhibitoren | |
MY135869A (en) | Inhibitors of aspartyl protease | |
MX9708055A (es) | Inhibidores de aspartil proteasa consistentes en sulfonamida que contiene heterociclo oxigenado. | |
MX9708057A (es) | Sulfonamidas que contienen thf inhibidoras de la aspartilproteasa. | |
IT1318424B1 (it) | Composti con attivita' anti-hiv. | |
TH57871B (th) | สารยับยั้งเอ็นไซม์แอสพาร์ทิลโปรตีเอส | |
TNSN03129A1 (fr) | Inhibiteurs de protease du vih, compositions les contenant , leurs utilisation pharmaceutiques, et matieres pour leur synthese . | |
TNSN03088A1 (fr) | Derives de pyrazole pour le traitement d'une infection par le vih | |
TH35214A (th) | ตัวยับยั้งแอสพาร์ทิลโปรทีเอส | |
WO1998040357A3 (fr) | Inhibiteurs de la protease du vih |