IT1318424B1 - Composti con attivita' anti-hiv. - Google Patents
Composti con attivita' anti-hiv.Info
- Publication number
- IT1318424B1 IT1318424B1 IT2000MI000629A ITMI20000629A IT1318424B1 IT 1318424 B1 IT1318424 B1 IT 1318424B1 IT 2000MI000629 A IT2000MI000629 A IT 2000MI000629A IT MI20000629 A ITMI20000629 A IT MI20000629A IT 1318424 B1 IT1318424 B1 IT 1318424B1
- Authority
- IT
- Italy
- Prior art keywords
- compounds
- xenaldial
- hiv activity
- group
- inhibitors
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000036436 anti-hiv Effects 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- ODRKIKHWTZCVCM-UHFFFAOYSA-N 2-[4-(4-oxaldehydoylphenyl)phenyl]-2-oxoacetaldehyde Chemical compound C1=CC(C(=O)C=O)=CC=C1C1=CC=C(C(=O)C=O)C=C1 ODRKIKHWTZCVCM-UHFFFAOYSA-N 0.000 abstract 2
- PCESDWWIFVPSOX-UHFFFAOYSA-N 4-[[2-oxo-2-(4-phenylphenyl)ethylidene]amino]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1N=CC(=O)C1=CC=C(C=2C=CC=CC=2)C=C1 PCESDWWIFVPSOX-UHFFFAOYSA-N 0.000 abstract 2
- BPOMPTVRBWXZBY-UHFFFAOYSA-N 4-[[1-ethoxy-2-oxo-2-(4-phenylphenyl)ethyl]amino]benzoic acid Chemical compound C=1C=C(C=2C=CC=CC=2)C=CC=1C(=O)C(OCC)NC1=CC=C(C(O)=O)C=C1 BPOMPTVRBWXZBY-UHFFFAOYSA-N 0.000 abstract 1
- 208000030507 AIDS Diseases 0.000 abstract 1
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 abstract 1
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 239000002259 anti human immunodeficiency virus agent Substances 0.000 abstract 1
- 229940124411 anti-hiv antiviral agent Drugs 0.000 abstract 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229940124524 integrase inhibitor Drugs 0.000 abstract 1
- 239000002850 integrase inhibitor Substances 0.000 abstract 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/121—Ketones acyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2000MI000629A IT1318424B1 (it) | 2000-03-24 | 2000-03-24 | Composti con attivita' anti-hiv. |
| PCT/EP2001/003343 WO2001070216A2 (en) | 2000-03-24 | 2001-03-23 | Diphenyl ketoaldehyde derivatives with anti-hiv activity |
| EP01938038A EP1267858B1 (en) | 2000-03-24 | 2001-03-23 | Diphenyl ketoaldehyde derivatives with anti-hiv activity |
| AU2001263803A AU2001263803A1 (en) | 2000-03-24 | 2001-03-23 | Compounds with anti-hiv activity |
| US10/239,239 US20040058999A1 (en) | 2000-03-24 | 2001-03-23 | Compounds with anti-hiv activity |
| ES01938038T ES2225550T3 (es) | 2000-03-24 | 2001-03-23 | Derivados de difenil cetoaldehida con actividad anti-vih. |
| RU2002125444/15A RU2002125444A (ru) | 2000-03-24 | 2001-03-23 | Соединения с активностью против вич |
| CNB018069568A CN1193747C (zh) | 2000-03-24 | 2001-03-23 | 具抗hiv活性的联苯酮醛衍生物 |
| DE60104530T DE60104530T2 (de) | 2000-03-24 | 2001-03-23 | Diphenyl Ketoaldehyde-Derivate mit Wirkung gegen HIV |
| MXPA02009173A MXPA02009173A (es) | 2000-03-24 | 2001-03-23 | Compuestos con actividad contra el virus de la inmunodeficiencia humana. |
| JP2001568414A JP2003527419A (ja) | 2000-03-24 | 2001-03-23 | 抗ｈｉｖ活性を有する化合物 |
| CA002403707A CA2403707A1 (en) | 2000-03-24 | 2001-03-23 | Diphenyl ketoaldehyde derivatives with anti-hiv activity |
| AT01938038T ATE271859T1 (de) | 2000-03-24 | 2001-03-23 | Diphenyl ketoaldehyde-derivate mit wirkung gegen hiv |
| BR0109345-2A BR0109345A (pt) | 2000-03-24 | 2001-03-23 | Compostos com atividade anti-hiv |
| ZA200207586A ZA200207586B (en) | 2000-03-24 | 2002-09-20 | Diphenyl ketoaldehyde derivatives with anti-HIV activity. |
| NO20024522A NO20024522L (no) | 2000-03-24 | 2002-09-20 | Sammensetninger med anti-hiv-aktivitet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2000MI000629A IT1318424B1 (it) | 2000-03-24 | 2000-03-24 | Composti con attivita' anti-hiv. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI20000629A0 ITMI20000629A0 (it) | 2000-03-24 |
| ITMI20000629A1 ITMI20000629A1 (it) | 2001-09-24 |
| IT1318424B1 true IT1318424B1 (it) | 2003-08-25 |
Family
ID=11444629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT2000MI000629A IT1318424B1 (it) | 2000-03-24 | 2000-03-24 | Composti con attivita' anti-hiv. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20040058999A1 (it) |
| EP (1) | EP1267858B1 (it) |
| JP (1) | JP2003527419A (it) |
| CN (1) | CN1193747C (it) |
| AT (1) | ATE271859T1 (it) |
| AU (1) | AU2001263803A1 (it) |
| BR (1) | BR0109345A (it) |
| CA (1) | CA2403707A1 (it) |
| DE (1) | DE60104530T2 (it) |
| ES (1) | ES2225550T3 (it) |
| IT (1) | IT1318424B1 (it) |
| MX (1) | MXPA02009173A (it) |
| NO (1) | NO20024522L (it) |
| RU (1) | RU2002125444A (it) |
| WO (1) | WO2001070216A2 (it) |
| ZA (1) | ZA200207586B (it) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20020966A1 (it) * | 2002-05-08 | 2003-11-10 | Unihart Corp | Composti attivi contro i rhinovirus |
| UA87884C2 (uk) * | 2004-12-03 | 2009-08-25 | Мерк Энд Ко., Инк. | Безводна кристалічна калієва сіль інгібітора віл-інтегрази |
| CN104031117B (zh) * | 2014-04-23 | 2017-07-11 | 南开大学 | 美国癌症数据库化合物在抗艾滋病毒1型蛋白酶活性上的新用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4724232A (en) * | 1985-03-16 | 1988-02-09 | Burroughs Wellcome Co. | Treatment of human viral infections |
| US5147652A (en) * | 1990-07-03 | 1992-09-15 | Cell Research Corporation | Autobiotics and their use in eliminating nonself cells in vivo |
-
2000
- 2000-03-24 IT IT2000MI000629A patent/IT1318424B1/it active
-
2001
- 2001-03-23 CN CNB018069568A patent/CN1193747C/zh not_active Expired - Fee Related
- 2001-03-23 JP JP2001568414A patent/JP2003527419A/ja active Pending
- 2001-03-23 US US10/239,239 patent/US20040058999A1/en not_active Abandoned
- 2001-03-23 BR BR0109345-2A patent/BR0109345A/pt not_active Application Discontinuation
- 2001-03-23 AU AU2001263803A patent/AU2001263803A1/en not_active Abandoned
- 2001-03-23 MX MXPA02009173A patent/MXPA02009173A/es not_active Application Discontinuation
- 2001-03-23 ES ES01938038T patent/ES2225550T3/es not_active Expired - Lifetime
- 2001-03-23 RU RU2002125444/15A patent/RU2002125444A/ru unknown
- 2001-03-23 EP EP01938038A patent/EP1267858B1/en not_active Expired - Lifetime
- 2001-03-23 WO PCT/EP2001/003343 patent/WO2001070216A2/en active IP Right Grant
- 2001-03-23 DE DE60104530T patent/DE60104530T2/de not_active Expired - Fee Related
- 2001-03-23 AT AT01938038T patent/ATE271859T1/de not_active IP Right Cessation
- 2001-03-23 CA CA002403707A patent/CA2403707A1/en not_active Abandoned
-
2002
- 2002-09-20 ZA ZA200207586A patent/ZA200207586B/xx unknown
- 2002-09-20 NO NO20024522A patent/NO20024522L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200207586B (en) | 2003-09-22 |
| ATE271859T1 (de) | 2004-08-15 |
| NO20024522L (no) | 2002-11-25 |
| NO20024522D0 (no) | 2002-09-20 |
| RU2002125444A (ru) | 2004-03-20 |
| ES2225550T3 (es) | 2005-03-16 |
| ITMI20000629A1 (it) | 2001-09-24 |
| CA2403707A1 (en) | 2001-09-27 |
| EP1267858B1 (en) | 2004-07-28 |
| AU2001263803A1 (en) | 2001-10-03 |
| DE60104530D1 (de) | 2004-09-02 |
| CN1419447A (zh) | 2003-05-21 |
| BR0109345A (pt) | 2002-12-17 |
| DE60104530T2 (de) | 2005-09-01 |
| US20040058999A1 (en) | 2004-03-25 |
| CN1193747C (zh) | 2005-03-23 |
| WO2001070216A3 (en) | 2001-12-27 |
| ITMI20000629A0 (it) | 2000-03-24 |
| EP1267858A2 (en) | 2003-01-02 |
| MXPA02009173A (es) | 2003-03-12 |
| JP2003527419A (ja) | 2003-09-16 |
| WO2001070216A2 (en) | 2001-09-27 |
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