ATE376543T1 - Indazol-verbindungen und pharmazeutische zusammensetzungen zur hemmung von proteinkinasen und verfahren zu ihrer verwendung - Google Patents

Indazol-verbindungen und pharmazeutische zusammensetzungen zur hemmung von proteinkinasen und verfahren zu ihrer verwendung

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Publication number
ATE376543T1
ATE376543T1 AT00943375T AT00943375T ATE376543T1 AT E376543 T1 ATE376543 T1 AT E376543T1 AT 00943375 T AT00943375 T AT 00943375T AT 00943375 T AT00943375 T AT 00943375T AT E376543 T1 ATE376543 T1 AT E376543T1
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AT
Austria
Prior art keywords
methods
pharmaceutical compositions
protein kinases
inhibiting protein
indazole compounds
Prior art date
Application number
AT00943375T
Other languages
German (de)
English (en)
Inventor
Robert Kania
Steven Bender
Allen Borchardt
John Braganza
Stephan Cripps
Ye Hua
Michael Johnson
Theodore Johnson
Hiep Luu
Cynthia Palmer
Siegfried Reich
Anna Tempczyk-Russell
Min Teng
Christine Thomas
Michael Varney
Michael Wallace
Michael Collins
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22498654&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE376543(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Agouron Pharma filed Critical Agouron Pharma
Application granted granted Critical
Publication of ATE376543T1 publication Critical patent/ATE376543T1/de

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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P27/00—Drugs for disorders of the senses
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D491/04—Ortho-condensed systems

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  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT00943375T 1999-07-02 2000-06-30 Indazol-verbindungen und pharmazeutische zusammensetzungen zur hemmung von proteinkinasen und verfahren zu ihrer verwendung ATE376543T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14213099P 1999-07-02 1999-07-02

Publications (1)

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ATE376543T1 true ATE376543T1 (de) 2007-11-15

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AT00943375T ATE376543T1 (de) 1999-07-02 2000-06-30 Indazol-verbindungen und pharmazeutische zusammensetzungen zur hemmung von proteinkinasen und verfahren zu ihrer verwendung

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EP (2) EP1218348B1 (instruction)
JP (2) JP3878849B2 (instruction)
KR (1) KR100529639B1 (instruction)
CN (2) CN1137884C (instruction)
AP (1) AP1486A (instruction)
AR (2) AR035554A1 (instruction)
AT (1) ATE376543T1 (instruction)
AU (1) AU777701B2 (instruction)
BE (1) BE2013C015I2 (instruction)
BG (1) BG66070B1 (instruction)
BR (1) BRPI0012352B8 (instruction)
CA (1) CA2383630C (instruction)
CO (1) CO5190686A1 (instruction)
CR (2) CR6517A (instruction)
CY (3) CY1107148T1 (instruction)
CZ (1) CZ301667B6 (instruction)
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ES (2) ES2293906T3 (instruction)
FR (1) FR13C0010I2 (instruction)
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DZ3377A1 (fr) 1999-12-24 2001-07-05 Aventis Pharma Ltd Azaindoles
JP2003522174A (ja) 2000-02-07 2003-07-22 ブリストル−マイヤーズ スクイブ カンパニー サイクリン依存性キナーゼの３−アミノピラゾール阻害剤
US20040087798A1 (en) * 2000-03-14 2004-05-06 Akira Yamada Novel amide compounds
ATE287886T1 (de) 2000-04-25 2005-02-15 Bristol Myers Squibb Co Verwendung von 5-thio, sulfinyl- und sulfonylpyrazolo 3,4-b) pyridinen als cyclin- abhängige kinase-hemmer
WO2002012228A1 (en) 2000-08-09 2002-02-14 Astrazeneca Ab Cinnoline compounds
EP1313726A1 (en) 2000-08-09 2003-05-28 AstraZeneca AB Quinoline derivatives having vegf inhibiting activity
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AU2001293275B2 (en) 2000-09-11 2005-04-14 Novartis Vaccines And Diagnostic Inc. Quinolinone derivatives as tyrosine kinase inhibitors
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FR2831537B1 (fr) * 2001-10-26 2008-02-29 Aventis Pharma Sa Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation
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IL161576A0 (en) * 2001-10-26 2004-09-27 Aventis Pharma Inc Benzimidazoles and analogues and their use as protein kinases inhibitors
US6897208B2 (en) * 2001-10-26 2005-05-24 Aventis Pharmaceuticals Inc. Benzimidazoles
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