MXPA01008182A
(es)
|
1999-02-10 |
2003-08-20 |
Astrazeneca Ab |
Derivados de quinazolina como inhibidores de angiotensina.
|
PE20010306A1
(es)
*
|
1999-07-02 |
2001-03-29 |
Agouron Pharma |
Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
|
BR0017038A
(pt)
|
1999-12-24 |
2003-01-07 |
Aventis Pharma Ltd |
Azaindóis
|
ES2228905T3
(es)
|
2000-02-07 |
2005-04-16 |
Bristol-Myers Squibb Co. |
Inhibidores 3-aminopirazoles de quinasa dependientes de ciclinas.
|
AU2001241128A1
(en)
*
|
2000-03-14 |
2001-09-24 |
Fujisawa Pharmaceutical Co. Ltd. |
Novel amide compounds
|
AU2001253540A1
(en)
|
2000-04-25 |
2001-11-07 |
Bristol-Myers Squibb Company |
Use of 5-thio-, sulfinyl- and sulfonylpyrazolo(3,4-b)-pyridines as cyclin dependent kinase inhibitors
|
JP2004505964A
(ja)
|
2000-08-09 |
2004-02-26 |
アストラゼネカ アクチボラグ |
Vegf阻害活性を有するキノリン誘導体
|
DE60137234D1
(de)
|
2000-08-09 |
2009-02-12 |
Astrazeneca Ab |
Cinnoline verbindungen
|
US6756383B2
(en)
|
2000-09-01 |
2004-06-29 |
Chiron Corporation |
Heterocyclic derivatives of quinolinone benimidazoles
|
AP1666A
(en)
|
2000-09-11 |
2006-09-29 |
Chiron Corp |
Quinolinone derivatives as tyrosine kinase inhibitors.
|
DE60126997T2
(de)
|
2000-10-20 |
2007-10-25 |
Eisai R&D Management Co., Ltd. |
Stickstoff-enthaltende aromatische ringverbindungen zur behandlung von tumorerkrankungen
|
TWI243164B
(en)
|
2001-02-13 |
2005-11-11 |
Aventis Pharma Gmbh |
Acylated indanyl amines and their use as pharmaceuticals
|
GB0115109D0
(en)
|
2001-06-21 |
2001-08-15 |
Aventis Pharma Ltd |
Chemical compounds
|
EP1401831A1
(en)
*
|
2001-07-03 |
2004-03-31 |
Chiron Corporation |
Indazole benzimidazole compounds as tyrosine and serine/threonine kinase inhibitors
|
US7642278B2
(en)
|
2001-07-03 |
2010-01-05 |
Novartis Vaccines And Diagnostics, Inc. |
Indazole benzimidazole compounds
|
WO2003024969A1
(en)
|
2001-09-14 |
2003-03-27 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
FR2831536A1
(fr)
*
|
2001-10-26 |
2003-05-02 |
Aventis Pharma Sa |
Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de kdr
|
WO2003035065A1
(en)
*
|
2001-10-26 |
2003-05-01 |
Aventis Pharmaceuticals Inc |
Benzimidazoles and analogues and their use as protein kinases inhibitors
|
US6897208B2
(en)
*
|
2001-10-26 |
2005-05-24 |
Aventis Pharmaceuticals Inc. |
Benzimidazoles
|
FR2831537B1
(fr)
*
|
2001-10-26 |
2008-02-29 |
Aventis Pharma Sa |
Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation
|
PT1474420E
(pt)
|
2002-02-01 |
2012-05-10 |
Astrazeneca Ab |
Compostos de quinazolina
|
US7166293B2
(en)
|
2002-03-29 |
2007-01-23 |
Carlsbad Technology, Inc. |
Angiogenesis inhibitors
|
US20050119278A1
(en)
*
|
2002-05-16 |
2005-06-02 |
Che-Ming Teng |
Anti-angiogenesis methods
|
US7186716B2
(en)
|
2002-08-12 |
2007-03-06 |
Sugen, Inc. |
3-Pyrrol-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors
|
BR0313743A
(pt)
|
2002-08-23 |
2005-07-05 |
Chiron Corp |
Benzimidazol quinolinonas e usos destas
|
JPWO2004050088A1
(ja)
*
|
2002-12-03 |
2006-03-30 |
協和醗酵工業株式会社 |
Jnk阻害剤
|
PL377713A1
(pl)
|
2002-12-19 |
2006-02-06 |
Pfizer Inc. |
Związki 2-(1H-indazol-6-iloamino)benzamidowe jako inhibitory kinaz białkowych użyteczne w leczeniu chorób oczu
|
US7192976B2
(en)
|
2002-12-21 |
2007-03-20 |
Angion Biomedica Corporation |
Small molecule modulators of hepatocyte growth factor (scatter factor) activity
|
US7135575B2
(en)
|
2003-03-03 |
2006-11-14 |
Array Biopharma, Inc. |
P38 inhibitors and methods of use thereof
|
PL214032B1
(pl)
|
2003-03-03 |
2013-06-28 |
Array Biopharma |
Zwiazki bedace inhibitorami kinazy p38, kompozycja farmaceutyczna je zawierajaca oraz ich zastosowanie do wytwarzania leku do leczenia stanu, w którym posredniczy kinaza p38
|
EP1613320A1
(en)
*
|
2003-04-03 |
2006-01-11 |
Pfizer Inc. |
Dosage forms comprising ag013736
|
EP1618133A1
(en)
*
|
2003-04-17 |
2006-01-25 |
Pfizer Inc. |
Crystal structure of vegfrkd: ligand complexes and methods of use thereof
|
FR2854159B1
(fr)
*
|
2003-04-25 |
2008-01-11 |
Aventis Pharma Sa |
Nouveaux derives de l'indole, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de kdr
|
TWI372050B
(en)
|
2003-07-03 |
2012-09-11 |
Astex Therapeutics Ltd |
(morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles
|
EP1651612B9
(en)
|
2003-07-22 |
2012-09-05 |
Astex Therapeutics Limited |
3,4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators
|
US7872014B2
(en)
|
2003-07-23 |
2011-01-18 |
Exelixis, Inc. |
Anaplastic lymphoma kinase modulators and methods of use
|
WO2005012257A1
(ja)
|
2003-07-30 |
2005-02-10 |
Kyowa Hakko Kogyo Co., Ltd. |
インダゾール誘導体
|
AU2004260759B2
(en)
*
|
2003-07-30 |
2010-04-22 |
Kyowa Hakko Kirin Co., Ltd. |
Protein kinase inhibitors
|
US7494983B2
(en)
*
|
2003-09-04 |
2009-02-24 |
Merck & Co. Inc. |
Ophthalmic compositions for treating ocular hypertension
|
US20050164300A1
(en)
*
|
2003-09-15 |
2005-07-28 |
Plexxikon, Inc. |
Molecular scaffolds for kinase ligand development
|
US20050182061A1
(en)
*
|
2003-10-02 |
2005-08-18 |
Jeremy Green |
Phthalimide compounds useful as protein kinase inhibitors
|
KR20060111520A
(ko)
|
2003-11-07 |
2006-10-27 |
카이론 코포레이션 |
Fgfr3의 억제 및 다발성 골수종의 치료
|
CN100450998C
(zh)
|
2003-11-11 |
2009-01-14 |
卫材R&D管理有限公司 |
脲衍生物的制备方法
|
AU2004293443A1
(en)
*
|
2003-11-19 |
2005-06-09 |
Signal Pharmaceuticals, Llc. |
Indazole Compounds and methods of use thereof as protein kinase inhibitors
|
GB0330002D0
(en)
|
2003-12-24 |
2004-01-28 |
Astrazeneca Ab |
Quinazoline derivatives
|
CN1922150A
(zh)
*
|
2004-02-27 |
2007-02-28 |
霍夫曼-拉罗奇有限公司 |
吲唑衍生物以及含有它们的药物组合物
|
EP1720855A4
(en)
*
|
2004-03-02 |
2008-12-17 |
Smithkline Beecham Corp |
HEMMER OF ACT ACTIVITY
|
JPWO2005094823A1
(ja)
*
|
2004-03-30 |
2007-08-16 |
協和醗酵工業株式会社 |
Flt−3阻害剤
|
JPWO2005108370A1
(ja)
*
|
2004-04-16 |
2008-03-21 |
味の素株式会社 |
ベンゼン化合物
|
AU2005325271A1
(en)
|
2004-05-06 |
2006-07-27 |
Plexxikon, Inc. |
PDE4B inhibitors and uses therefor
|
JP2008503470A
(ja)
*
|
2004-06-17 |
2008-02-07 |
ワイス |
ゴナドトロピン放出ホルモン受容体アンタゴニストの製造法
|
AU2005264996A1
(en)
*
|
2004-06-17 |
2006-01-26 |
Wyeth |
Gonadotropin releasing hormone receptor antagonists
|
BRPI0514687A
(pt)
*
|
2004-08-26 |
2008-06-17 |
Pfizer |
compostos amino heteroarila como inibidores de proteìna tirosina cinase
|
CN101048407A
(zh)
*
|
2004-09-03 |
2007-10-03 |
普莱希科公司 |
双环杂芳基pde4b抑制剂
|
EP1797881B1
(en)
|
2004-09-17 |
2009-04-15 |
Eisai R&D Management Co., Ltd. |
Medicinal composition with improved stability and reduced gelation properties
|
EP1647549A1
(en)
*
|
2004-10-14 |
2006-04-19 |
Laboratoire Theramex |
Indazoles, benzisoxazoles and benzisothiazoles as estrogenic agents
|
RU2007114112A
(ru)
*
|
2004-11-02 |
2008-12-10 |
Пфайзер Инк. (US) |
Способ получения индазольных соединений
|
KR20070085727A
(ko)
*
|
2004-11-02 |
2007-08-27 |
화이자 인코포레이티드 |
인다졸 화합물의 제조 방법
|
WO2006048751A1
(en)
*
|
2004-11-02 |
2006-05-11 |
Pfizer Inc. |
Polymorphic forms of 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-e-[2-(pyridin-2-yl)ethenyl]indazole
|
US9512125B2
(en)
|
2004-11-19 |
2016-12-06 |
The Regents Of The University Of California |
Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents
|
FR2878442B1
(fr)
*
|
2004-11-29 |
2008-10-24 |
Aventis Pharma Sa |
THIENO(2,3-c)PYRAZOLES SUBSTITUES, PROCEDE DE PREPARATION, COMPOSITIONS LES CONTENANT ET UTILISATION
|
US20060142247A1
(en)
*
|
2004-12-17 |
2006-06-29 |
Guy Georges |
Tricyclic heterocycles
|
NZ555982A
(en)
|
2004-12-30 |
2011-01-28 |
Astex Therapeutics Ltd |
Pyrazole compounds that modulate the activity of CDK, GSK and aurora kinases
|
US7622583B2
(en)
|
2005-01-14 |
2009-11-24 |
Chemocentryx, Inc. |
Heteroaryl sulfonamides and CCR2
|
ES2552338T3
(es)
|
2005-01-21 |
2015-11-27 |
Astex Therapeutics Limited |
Compuestos farmacéuticos
|
US8404718B2
(en)
|
2005-01-21 |
2013-03-26 |
Astex Therapeutics Limited |
Combinations of pyrazole kinase inhibitors
|
AU2006207321B2
(en)
|
2005-01-21 |
2012-09-06 |
Astex Therapeutics Limited |
Pharmaceutical compounds
|
AR054425A1
(es)
|
2005-01-21 |
2007-06-27 |
Astex Therapeutics Ltd |
Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico.
|
JP4804480B2
(ja)
*
|
2005-01-26 |
2011-11-02 |
シェーリング コーポレイション |
癌の処置のためのプロテインキナーゼインヒビターとしての、3−(インダゾール−5−イル)−(1,2,4)トリアジン誘導体、および関連する化合物
|
AU2006209712B2
(en)
|
2005-01-27 |
2011-06-09 |
Kyowa Hakko Kirin Co., Ltd. |
IGF-1R inhibitor
|
US7534796B2
(en)
|
2005-02-18 |
2009-05-19 |
Wyeth |
Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
|
US7538113B2
(en)
|
2005-02-18 |
2009-05-26 |
Wyeth |
4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
|
US7582634B2
(en)
|
2005-02-18 |
2009-09-01 |
Wyeth |
7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
|
ES2376347T3
(es)
|
2005-05-17 |
2012-03-13 |
Novartis Ag |
Métodos para sintetizar compuestos heteroc�?clicos.
|
US7531542B2
(en)
|
2005-05-18 |
2009-05-12 |
Wyeth |
Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor
|
EP1885338A1
(en)
*
|
2005-05-19 |
2008-02-13 |
Pfizer, Inc. |
Pharmaceutical compostions comprising an amorphous form of a vegf-r inhibitor
|
WO2006127587A1
(en)
*
|
2005-05-20 |
2006-11-30 |
Vertex Pharmaceuticals Incorporated |
Pyrrolopyridines useful as inhibitors of protein kinase
|
US7582636B2
(en)
|
2005-05-26 |
2009-09-01 |
Wyeth |
Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor
|
US7541367B2
(en)
|
2005-05-31 |
2009-06-02 |
Janssen Pharmaceutica, N.V. |
3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders
|
US7888381B2
(en)
|
2005-06-14 |
2011-02-15 |
Bristol-Myers Squibb Company |
Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof
|
WO2007015578A1
(ja)
|
2005-08-02 |
2007-02-08 |
Eisai R & D Management Co., Ltd. |
血管新生阻害物質の効果を検定する方法
|
JP2009517481A
(ja)
|
2005-11-29 |
2009-04-30 |
ノバルティス アクチエンゲゼルシャフト |
キノリノンの製剤
|
TW200732305A
(en)
*
|
2005-12-23 |
2007-09-01 |
Yung Shin Pharmaceutical Ind |
Cancer chemotherapy
|
SI1981851T1
(sl)
|
2006-01-31 |
2012-05-31 |
Array Biopharma Inc |
Kinazni inhibitorji in postopki za njihovo uporabo
|
AU2007228940A1
(en)
*
|
2006-03-23 |
2007-09-27 |
F. Hoffmann-La Roche Ag |
Substituted indazole derivatives, their manufacture and use as pharmaceutical agents
|
EP2004654B1
(en)
|
2006-04-04 |
2013-05-22 |
The Regents of the University of California |
Pyrazolopyrimidine derivatives for use as kinase antagonists
|
CN101443009A
(zh)
|
2006-05-18 |
2009-05-27 |
卫材R&D管理有限公司 |
针对甲状腺癌的抗肿瘤剂
|
EP2036893A4
(en)
|
2006-06-30 |
2011-04-13 |
Kyowa Hakko Kirin Co Ltd |
ABL Kinase Inhibitor
|
EP2036894A4
(en)
|
2006-06-30 |
2011-01-12 |
Kyowa Hakko Kirin Co Ltd |
AURORA INHIBITOR
|
US8519135B2
(en)
|
2006-07-14 |
2013-08-27 |
Chemocentryx, Inc. |
Heteroaryl sulfonamides and CCR2/CCR9
|
JPWO2008020606A1
(ja)
*
|
2006-08-16 |
2010-01-07 |
協和発酵キリン株式会社 |
血管新生阻害剤
|
US8865737B2
(en)
|
2006-08-28 |
2014-10-21 |
Eisai R&D Management Co., Ltd. |
Antitumor agent for undifferentiated gastric cancer
|
CL2007002617A1
(es)
|
2006-09-11 |
2008-05-16 |
Sanofi Aventis |
Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto.
|
EP2119707B1
(en)
|
2007-01-29 |
2015-01-14 |
Eisai R&D Management Co., Ltd. |
Composition for treatment of undifferentiated-type of gastric cancer
|
TW200901975A
(en)
|
2007-03-05 |
2009-01-16 |
Kyowa Hakko Kogyo Kk |
Pharmaceutical composition
|
CN103087043A
(zh)
*
|
2007-03-16 |
2013-05-08 |
中国人民解放军军事医学科学院放射与辐射医学研究所 |
具有抗增殖活性的苯甲酰胺类衍生物及其药用制剂
|
CA2682859C
(en)
*
|
2007-04-05 |
2013-10-08 |
Pfizer Products Inc. |
Crystalline forms of 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-e-[2-(pyridin-2-yl)ethenyl)indazole for treatment of abnormal cell growth in mammals
|
EP2002836B1
(en)
|
2007-05-31 |
2010-10-20 |
Nerviano Medical Sciences S.r.l. |
Cyclocondensed azaindoles active as kinase inhibitors
|
PT2175859E
(pt)
|
2007-07-12 |
2012-06-06 |
Chemocentryx Inc |
Heteroarilpiridil- e fenil-benzenossulfonamidas condensadas como moduladores de ccr2 para o tratamento de inflamação
|
WO2009046448A1
(en)
|
2007-10-04 |
2009-04-09 |
Intellikine, Inc. |
Chemical entities and therapeutic uses thereof
|
US8779197B2
(en)
*
|
2007-10-11 |
2014-07-15 |
Vertex Pharmaceuticals Incorporated |
Aryl amides useful as inhibitors of voltage-gated sodium channels
|
MX2010004819A
(es)
|
2007-11-02 |
2010-07-05 |
Vertex Pharma |
Derivados de [1h-pirazolo[3,4-b]piridin-4-il]-fenilo o piridin-2-ilo como proteina cinasa c-theta.
|
AU2008325608B2
(en)
|
2007-11-09 |
2013-03-14 |
Eisai R & D Management Co., Ltd. |
Combination of anti-angiogenic substance and anti-tumor platinum complex
|
WO2009088990A1
(en)
|
2008-01-04 |
2009-07-16 |
Intellikine, Inc. |
Certain chemical entities, compositions and methods
|
US8193182B2
(en)
|
2008-01-04 |
2012-06-05 |
Intellikine, Inc. |
Substituted isoquinolin-1(2H)-ones, and methods of use thereof
|
WO2009114874A2
(en)
|
2008-03-14 |
2009-09-17 |
Intellikine, Inc. |
Benzothiazole kinase inhibitors and methods of use
|
JP5547099B2
(ja)
|
2008-03-14 |
2014-07-09 |
インテリカイン, エルエルシー |
キナーゼ阻害剤および使用方法
|
RU2479579C2
(ru)
|
2008-04-28 |
2013-04-20 |
Асахи Касеи Фарма Корпорейшн |
Производное фенилпропионовой кислоты и его применение
|
US20110224223A1
(en)
|
2008-07-08 |
2011-09-15 |
The Regents Of The University Of California, A California Corporation |
MTOR Modulators and Uses Thereof
|
BRPI0915231A2
(pt)
|
2008-07-08 |
2018-06-12 |
Intellikine Inc |
compostos inibidores de quinase e métodos de uso
|
CA2767331A1
(en)
|
2008-07-10 |
2010-01-14 |
Angion Biomedica Corp. |
Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity
|
US8703778B2
(en)
|
2008-09-26 |
2014-04-22 |
Intellikine Llc |
Heterocyclic kinase inhibitors
|
WO2010045542A2
(en)
|
2008-10-16 |
2010-04-22 |
The Regents Of The University Of California |
Fused ring heteroaryl kinase inhibitors
|
US8476431B2
(en)
|
2008-11-03 |
2013-07-02 |
Itellikine LLC |
Benzoxazole kinase inhibitors and methods of use
|
ES2882797T3
(es)
|
2009-04-02 |
2021-12-02 |
Merck Serono Sa |
Inhibidores de dihidroorotato deshidrogenasa
|
JP5789252B2
(ja)
|
2009-05-07 |
2015-10-07 |
インテリカイン, エルエルシー |
複素環式化合物およびその使用
|
PT2464232E
(pt)
|
2009-08-10 |
2016-02-01 |
Samumed Llc |
Inibidores de indazol da via de sinalização wnt e usos terapêuticos dos mesmos
|
WO2011047384A2
(en)
|
2009-10-16 |
2011-04-21 |
The Regents Of The University Of California |
Methods of inhibiting ire1
|
WO2011073521A1
(en)
|
2009-12-15 |
2011-06-23 |
Petri Salven |
Methods for enriching adult-derived endothelial progenitor cells and uses thereof
|
DK3001903T3
(en)
|
2009-12-21 |
2017-12-18 |
Samumed Llc |
1H-PYRAZOLO [3,4 -?] PYRIDINES AND THERAPEUTIC APPLICATIONS THEREOF
|
AU2010343102B2
(en)
|
2009-12-29 |
2016-03-24 |
Dana-Farber Cancer Institute, Inc. |
Type II Raf kinase inhibitors
|
UY33236A
(es)
|
2010-02-25 |
2011-09-30 |
Novartis Ag |
Inhibidores dimericos de las iap
|
CN103080093A
(zh)
*
|
2010-03-16 |
2013-05-01 |
达纳-法伯癌症研究所公司 |
吲唑化合物及其应用
|
EP2571357B1
(en)
|
2010-05-21 |
2016-07-06 |
Infinity Pharmaceuticals, Inc. |
Chemical compounds, compositions and methods for kinase modulation
|
CN102958523B
(zh)
|
2010-06-25 |
2014-11-19 |
卫材R&D管理有限公司 |
使用具有激酶抑制作用的组合的抗肿瘤剂
|
WO2012012750A1
(en)
|
2010-07-23 |
2012-01-26 |
Trustees Of Boston University |
ANTI-DEsupR INHIBITORS AS THERAPEUTICS FOR INHIBITION OF PATHOLOGICAL ANGIOGENESIS AND TUMOR CELL INVASIVENESS AND FOR MOLECULAR IMAGING AND TARGETED DELIVERY
|
CN103298474B
(zh)
|
2010-11-10 |
2016-06-29 |
无限药品股份有限公司 |
杂环化合物及其用途
|
US20130266590A1
(en)
|
2010-12-13 |
2013-10-10 |
Novartis Ag |
Dimeric iap inhibitors
|
UY33794A
(es)
|
2010-12-13 |
2012-07-31 |
Novartis Ag |
Inhibidores diméricos de las iap
|
US8754114B2
(en)
|
2010-12-22 |
2014-06-17 |
Incyte Corporation |
Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
|
TWI659956B
(zh)
|
2011-01-10 |
2019-05-21 |
美商英菲尼提製藥股份有限公司 |
製備異喹啉酮之方法及異喹啉酮之固體形式
|
US9295673B2
(en)
|
2011-02-23 |
2016-03-29 |
Intellikine Llc |
Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof
|
EP2694060A4
(en)
*
|
2011-04-01 |
2014-09-10 |
Univ Utah Res Found |
SUBSTITUTED 3- (1H-BENZO- {D} -IMIDAZOL-2-YL-) 1H-INDAZOL ANALOGUE AS PDK1 KINASE INHIBITOR
|
MX2013009931A
(es)
|
2011-04-18 |
2013-10-01 |
Eisai R&D Man Co Ltd |
Agentes terapeuticos contra tumores.
|
ES2841809T3
(es)
|
2011-06-03 |
2021-07-09 |
Eisai R&D Man Co Ltd |
Biomarcadores para pronosticar y evaluar el grado de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib
|
JP6027610B2
(ja)
|
2011-07-19 |
2016-11-16 |
インフィニティー ファーマシューティカルズ, インコーポレイテッド |
複素環式化合物及びその使用
|
AR088218A1
(es)
|
2011-07-19 |
2014-05-21 |
Infinity Pharmaceuticals Inc |
Compuestos heterociclicos utiles como inhibidores de pi3k
|
US8575336B2
(en)
|
2011-07-27 |
2013-11-05 |
Pfizer Limited |
Indazoles
|
MX2014002542A
(es)
|
2011-08-29 |
2014-07-09 |
Infinity Pharmaceuticals Inc |
Compuestos heterociclicos y usos de los mismos.
|
WO2013077921A2
(en)
|
2011-09-02 |
2013-05-30 |
The Regents Of The University Of California |
Substituted pyrazolo[3,4-d]pyrimidines and uses thereof
|
PE20141678A1
(es)
|
2011-09-14 |
2014-11-21 |
Samumed Llc |
Indazol-3-carboxamidas y su uso como inhibidores de la ruta de senalizacion de wnt/b-catenina
|
CN102432595B
(zh)
*
|
2011-09-14 |
2013-09-25 |
湖南有色凯铂生物药业有限公司 |
N-吲哚-1-酰胺类化合物及作为抗癌药物的应用
|
EP2771337B1
(en)
|
2011-09-27 |
2017-08-02 |
Novartis AG |
3-(pyrimidin-4-yl)-oxazolidin-2-ones as inhibitors of mutant idh
|
EP2822935B1
(en)
|
2011-11-17 |
2019-05-15 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of c-jun-n-terminal kinase (jnk)
|
CA2856824A1
(en)
|
2011-12-05 |
2013-06-13 |
Novartis Ag |
Cyclic urea derivatives as androgen receptor antagonists
|
FR2985257B1
(fr)
*
|
2011-12-28 |
2014-02-14 |
Sanofi Sa |
Composes dimeres agonistes des recepteurs des fgfs (fgfrs), leur procede de preparation et leur application en therapeutique
|
HK1205758A1
(en)
|
2012-01-09 |
2015-12-24 |
Novartis Ag |
Rnai agents to treat beta-catenin related diseases
|
UY34591A
(es)
|
2012-01-26 |
2013-09-02 |
Novartis Ag |
Compuestos de imidazopirrolidinona
|
PH12017500997A1
(en)
|
2012-04-04 |
2018-02-19 |
Samumed Llc |
Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
|
US8940742B2
(en)
|
2012-04-10 |
2015-01-27 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
RU2689141C2
(ru)
|
2012-05-04 |
2019-05-24 |
СЭМЬЮМЕД, ЭлЭлСи |
1н-пиразоло[3,4-b]пиридины и их терапевтические применения
|
PT3495367T
(pt)
|
2012-06-13 |
2020-11-12 |
Incyte Holdings Corp |
Compostos tricíclicos substituídos como inibidores de fgfr
|
JP6231262B2
(ja)
*
|
2012-06-20 |
2017-11-15 |
大日本印刷株式会社 |
ピタバスタチンカルシウムの前駆体の製造法
|
US8828998B2
(en)
|
2012-06-25 |
2014-09-09 |
Infinity Pharmaceuticals, Inc. |
Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
|
US9388185B2
(en)
|
2012-08-10 |
2016-07-12 |
Incyte Holdings Corporation |
Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
|
JP2015532287A
(ja)
|
2012-09-26 |
2015-11-09 |
ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア |
Ire1の調節
|
EP2909194A1
(en)
|
2012-10-18 |
2015-08-26 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (cdk7)
|
WO2014063061A1
(en)
|
2012-10-19 |
2014-04-24 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged small molecules as inducers of protein degradation
|
US10000483B2
(en)
|
2012-10-19 |
2018-06-19 |
Dana-Farber Cancer Institute, Inc. |
Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
|
JP6584952B2
(ja)
|
2012-11-01 |
2019-10-02 |
インフィニティー ファーマシューティカルズ, インコーポレイテッド |
Pi3キナーゼアイソフォームモジュレーターを用いる癌の治療
|
CN103804349A
(zh)
*
|
2012-11-01 |
2014-05-21 |
杨子娇 |
一类治疗青光眼的化合物及其用途
|
US9266892B2
(en)
|
2012-12-19 |
2016-02-23 |
Incyte Holdings Corporation |
Fused pyrazoles as FGFR inhibitors
|
JPWO2014098176A1
(ja)
|
2012-12-21 |
2017-01-12 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
キノリン誘導体のアモルファス及びその製造方法
|
EP2943198B1
(en)
|
2013-01-08 |
2019-07-17 |
Samumed, LLC |
3-(benzoimidazol-2-yl)-indazole inhibitors of the wnt signaling pathway and therapeutic uses thereof
|
CN104370889A
(zh)
*
|
2013-01-24 |
2015-02-25 |
韩冰 |
一类降低眼压的化合物及其制备方法和用途
|
CA2899968C
(en)
*
|
2013-02-02 |
2016-12-20 |
Chia Tai Tianqing Pharmaceutical Group Co., Ltd. |
Substituted 2-aminopyridine protein kinase inhibitor
|
EP3360870A1
(en)
|
2013-02-19 |
2018-08-15 |
Novartis AG |
Benzothiophene derivatives and compositions thereof as selective estrogen receptor degraders
|
MX355945B
(es)
|
2013-03-14 |
2018-05-07 |
Novartis Ag |
3-pirimidin-4-il-oxazolidin-2-onas como inhibidoras de idh mutante.
|
AU2014229283B2
(en)
|
2013-03-14 |
2016-07-28 |
Novartis Ag |
3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
|
US9481667B2
(en)
|
2013-03-15 |
2016-11-01 |
Infinity Pharmaceuticals, Inc. |
Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
|
WO2014147586A1
(en)
|
2013-03-22 |
2014-09-25 |
Novartis Ag |
1-(2-(ethylamino)pyrimidin-4-yl)pyrrolidin-2-ones as inhibitors of mutant idh
|
US9533984B2
(en)
|
2013-04-19 |
2017-01-03 |
Incyte Holdings Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
NZ714049A
(en)
|
2013-05-14 |
2020-05-29 |
Eisai R&D Man Co Ltd |
Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
|
US20150018376A1
(en)
*
|
2013-05-17 |
2015-01-15 |
Novartis Ag |
Pyrimidin-4-yl)oxy)-1h-indole-1-carboxamide derivatives and use thereof
|
CN103387565B
(zh)
*
|
2013-07-29 |
2014-10-29 |
苏州明锐医药科技有限公司 |
阿西替尼的制备方法
|
HUE057734T2
(hu)
|
2013-10-04 |
2022-06-28 |
Infinity Pharmaceuticals Inc |
Heterociklusos vegyületek és alkalmazásuk
|
WO2015051241A1
(en)
|
2013-10-04 |
2015-04-09 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
CN105849099B
(zh)
|
2013-10-18 |
2020-01-17 |
达纳-法伯癌症研究所股份有限公司 |
周期蛋白依赖性激酶7(cdk7)的多环抑制剂
|
EP3057955B1
(en)
|
2013-10-18 |
2018-04-11 |
Syros Pharmaceuticals, Inc. |
Heteroaromatic compounds useful for the treatment of prolferative diseases
|
CN103570696B
(zh)
*
|
2013-11-06 |
2016-02-24 |
湖南欧亚生物有限公司 |
一种阿西替尼中间体的制备方法以及在制备阿西替尼中的应用
|
WO2015067224A1
(en)
|
2013-11-08 |
2015-05-14 |
Zentiva, K.S. |
Salts of 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-e-[2-(pyridin-2-yl)ethanyl] indazole
|
WO2015092634A1
(en)
|
2013-12-16 |
2015-06-25 |
Novartis Ag |
1,2,3,4-tetrahydroisoquinoline compounds and compositions as selective estrogen receptor antagonists and degraders
|
ES2699354T3
(es)
|
2014-01-17 |
2019-02-08 |
Novartis Ag |
Derivados de 1-(triazin-3-il/piridazin-3-il)-piper(-azin)idina y composiciones de las mismas para inhibir la actividad de SHP2
|
CN105899491B
(zh)
|
2014-01-17 |
2019-04-02 |
诺华股份有限公司 |
用于抑制shp2活性的1-哒嗪-/三嗪-3-基-哌(-嗪)/啶/吡咯烷衍生物及其组合物
|
JO3517B1
(ar)
|
2014-01-17 |
2020-07-05 |
Novartis Ag |
ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2
|
CA2943075C
(en)
|
2014-03-19 |
2023-02-28 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
|
RU2667486C2
(ru)
*
|
2014-03-31 |
2018-09-20 |
Сэндзю Фармацевтикал Ко., Лтд. |
Производное алкинилиндазола и его применение
|
WO2015160975A2
(en)
|
2014-04-16 |
2015-10-22 |
Infinity Pharmaceuticals, Inc. |
Combination therapies
|
WO2015164614A1
(en)
|
2014-04-23 |
2015-10-29 |
Dana-Farber Cancer Institute, Inc. |
Janus kinase inhibitors and uses thereof
|
US9862688B2
(en)
|
2014-04-23 |
2018-01-09 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged janus kinase inhibitors and uses thereof
|
AU2015265607A1
(en)
|
2014-05-28 |
2016-11-17 |
Idenix Pharmaceuticals Llc |
Nucleoside derivatives for the treatment of cancer
|
CN104072484B
(zh)
*
|
2014-07-07 |
2016-07-06 |
渤海大学 |
氮-(4-(芳巯基)-1氢-吲唑-3-基)-1-(芳杂环取代)甲基亚胺类化合物及其药学上可接受的盐及其制备方法和应用
|
AR101196A1
(es)
|
2014-07-16 |
2016-11-30 |
Gruenenthal Gmbh |
Compuestos de pirimidina sustituidos
|
AR101198A1
(es)
|
2014-07-16 |
2016-11-30 |
Gruenenthal Gmbh |
Pirimidinas 2,5-sustituidas como inhibidores de pde4b
|
RS63559B1
(sr)
|
2014-08-28 |
2022-10-31 |
Eisai R&D Man Co Ltd |
Derivat hinolina velike čistoće i postupak za njegovu proizvodnju
|
WO2016040184A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
|
WO2016040185A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof
|
WO2016040193A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
|
WO2016040188A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
|
WO2016040190A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
|
WO2016040182A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof
|
WO2016040181A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
|
WO2016040180A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
|
JP6723663B2
(ja)
|
2014-09-17 |
2020-07-15 |
セルジーン クオンティセル リサーチ,インク. |
ヒストンデメチラーゼ阻害剤
|
US9708348B2
(en)
|
2014-10-03 |
2017-07-18 |
Infinity Pharmaceuticals, Inc. |
Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
|
US10851105B2
(en)
|
2014-10-22 |
2020-12-01 |
Incyte Corporation |
Bicyclic heterocycles as FGFR4 inhibitors
|
EP3226689B1
(en)
|
2014-12-05 |
2020-01-15 |
Merck Sharp & Dohme Corp. |
Novel tricyclic compounds as inhibitors of mutant idh enzymes
|
EP3226688B1
(en)
|
2014-12-05 |
2020-07-01 |
Merck Sharp & Dohme Corp. |
Tricyclic compounds as inhibitors of mutant idh enzymes
|
US10086000B2
(en)
|
2014-12-05 |
2018-10-02 |
Merck Sharp & Dohme Corp. |
Tricyclic compounds as inhibitors of mutant IDH enzymes
|
MA41140A
(fr)
|
2014-12-12 |
2017-10-17 |
Cancer Research Tech Ltd |
Dérivés de 2,4-dioxo-quinazoline-6-sulfonamide en tant qu'inhibiteurs de la parg
|
MA41179A
(fr)
*
|
2014-12-19 |
2017-10-24 |
Cancer Research Tech Ltd |
Composés inhibiteurs de parg
|
US10870651B2
(en)
|
2014-12-23 |
2020-12-22 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (CDK7)
|
EP4599890A2
(en)
|
2015-01-13 |
2025-08-13 |
Kyoto University |
Sunitinib for preventing and/or treating amyotrophic lateral sclerosis
|
WO2016134294A1
(en)
|
2015-02-20 |
2016-08-25 |
Incyte Corporation |
Bicyclic heterocycles as fgfr4 inhibitors
|
MA41551A
(fr)
|
2015-02-20 |
2017-12-26 |
Incyte Corp |
Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
|
TWI712601B
(zh)
|
2015-02-20 |
2020-12-11 |
美商英塞特公司 |
作為fgfr抑制劑之雙環雜環
|
SG11201706630UA
(en)
|
2015-02-25 |
2017-09-28 |
Eisai R&D Man Co Ltd |
Method for suppressing bitterness of quinoline derivative
|
KR20240064733A
(ko)
|
2015-03-04 |
2024-05-13 |
머크 샤프 앤드 돔 코포레이션 |
암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
|
US10550121B2
(en)
|
2015-03-27 |
2020-02-04 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
US9580406B2
(en)
|
2015-04-28 |
2017-02-28 |
Signa S.A. De C.V. |
Processes for the preparation of axitinib
|
EP3303361A1
(en)
|
2015-05-27 |
2018-04-11 |
Idenix Pharmaceuticals LLC |
Nucleotides for the treatment of cancer
|
WO2016200688A1
(en)
|
2015-06-06 |
2016-12-15 |
Cloudbreak Therapeutics, Llc |
Compositions and methods for treating pterygium
|
WO2016201370A1
(en)
|
2015-06-12 |
2016-12-15 |
Dana-Farber Cancer Institute, Inc. |
Combination therapy of transcription inhibitors and kinase inhibitors
|
SG11201710198YA
(en)
|
2015-06-16 |
2018-01-30 |
Eisai R&D Man Co Ltd |
Anticancer agent
|
US10308660B2
(en)
|
2015-06-19 |
2019-06-04 |
Novartis Ag |
Compounds and compositions for inhibiting the activity of SHP2
|
CN107922388B
(zh)
|
2015-06-19 |
2020-12-29 |
诺华股份有限公司 |
用于抑制shp2活性的化合物和组合物
|
US10975080B2
(en)
|
2015-06-19 |
2021-04-13 |
Novartis Ag |
Compounds and compositions for inhibiting the activity of SHP2
|
GB201511382D0
(en)
|
2015-06-29 |
2015-08-12 |
Imp Innovations Ltd |
Novel compounds and their use in therapy
|
GB201511790D0
(en)
|
2015-07-06 |
2015-08-19 |
Iomet Pharma Ltd |
Pharmaceutical compound
|
US10206909B2
(en)
|
2015-08-03 |
2019-02-19 |
Samumed, Llc |
3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
|
WO2017023996A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
|
US10285982B2
(en)
|
2015-08-03 |
2019-05-14 |
Samumed, Llc |
3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
|
WO2017024021A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc |
3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof
|
WO2017023993A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(1h-indol-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
|
WO2017024025A1
(en)
|
2015-08-03 |
2017-02-09 |
Sunil Kumar Kc |
3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
|
US10392383B2
(en)
|
2015-08-03 |
2019-08-27 |
Samumed, Llc |
3-(1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
|
WO2017023984A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
|
US10231956B2
(en)
|
2015-08-03 |
2019-03-19 |
Samumed, Llc |
3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
|
US10383861B2
(en)
|
2015-08-03 |
2019-08-20 |
Sammumed, LLC |
3-(1H-pyrrolo[2,3-C]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
|
WO2017023986A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc |
3-(1h-indol-2-yl)-1h-indazoles and therapeutic uses thereof
|
US10329309B2
(en)
|
2015-08-03 |
2019-06-25 |
Samumed, Llc |
3-(3H-imidazo[4,5-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
|
WO2017024026A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc |
3-(1h-indol-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
|
US10463651B2
(en)
|
2015-08-03 |
2019-11-05 |
Samumed, Llc |
3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-indazoles and therapeutic uses thereof
|
WO2017023972A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
|
WO2017023987A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
|
WO2017023988A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
|
US11453697B1
(en)
|
2015-08-13 |
2022-09-27 |
Merck Sharp & Dohme Llc |
Cyclic di-nucleotide compounds as sting agonists
|
TN2018000023A1
(en)
|
2015-08-13 |
2019-07-08 |
Merck Sharp & Dohme |
Cyclic di-nucleotide compounds as sting agonists.
|
ES2887426T3
(es)
|
2015-08-20 |
2021-12-22 |
Eisai R&D Man Co Ltd |
Lenvatinib combinado con etopósido e ifosfamida para su uso en el tratamiento de un tumor
|
EP3347018B1
(en)
|
2015-09-09 |
2021-09-01 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
WO2017048702A1
(en)
|
2015-09-14 |
2017-03-23 |
Infinity Pharmaceuticals, Inc. |
Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
|
WO2017062694A1
(en)
*
|
2015-10-07 |
2017-04-13 |
Diane Tang-Liu |
Compositions and methods of treating skin fibrotic disorders
|
CA3002875A1
(en)
*
|
2015-10-22 |
2017-04-27 |
Selvita S.A. |
Pyridone derivatives and their use as kinase inhibitors
|
US10899757B2
(en)
|
2015-11-06 |
2021-01-26 |
Samumed, Llc |
2-(1H-indazol-3-yl)-3H-imidazo[4,5-C]pyridines and their anti-inflammatory uses thereof
|
EP3389783B1
(en)
|
2015-12-15 |
2024-07-03 |
Merck Sharp & Dohme LLC |
Novel compounds as indoleamine 2,3-dioxygenase inhibitors
|
US10759806B2
(en)
|
2016-03-17 |
2020-09-01 |
Infinity Pharmaceuticals, Inc. |
Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors
|
AR108325A1
(es)
|
2016-04-27 |
2018-08-08 |
Samumed Llc |
Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
|
EP3452465B1
(en)
|
2016-05-04 |
2020-11-04 |
Genoscience Pharma |
Substituted 2, 4-diamino-quinoline derivatives for use in the treatment of proliferative diseases
|
ES2933109T3
(es)
|
2016-06-01 |
2023-02-02 |
Biosplice Therapeutics Inc |
Proceso para preparar N-(5-(3-(7-(3-fluorofenil)-3h-imidazo[4,5-c]piridin-2-il)-1h-indazol-5-il)piridin-3-il)-3-metilbutanamida
|
US10919914B2
(en)
|
2016-06-08 |
2021-02-16 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
EP3468972B1
(en)
|
2016-06-14 |
2020-05-20 |
Novartis Ag |
Compounds and compositions for inhibiting the activity of shp2
|
IL263680B1
(en)
|
2016-06-24 |
2025-06-01 |
Infinity Pharmaceuticals Inc |
Pi3k inhibitors for use in combination with a second therapeutic agent in treating, managing, or preventing cancer
|
SG10202008647TA
(en)
|
2016-10-04 |
2020-10-29 |
Merck Sharp & Dohme |
BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS
|
JP2019535672A
(ja)
|
2016-10-21 |
2019-12-12 |
サミュメッド リミテッド ライアビリティ カンパニー |
インダゾール−3−カルボキサミドの使用方法およびwnt/β−カテニンシグナル伝達経路阻害剤としてのそれらの使用
|
WO2018085865A1
(en)
|
2016-11-07 |
2018-05-11 |
Samumed, Llc |
Single-dose, ready-to-use injectable formulations
|
EP3541825A1
(en)
|
2016-11-21 |
2019-09-25 |
Idenix Pharmaceuticals LLC. |
Cyclic phosphate substituted nucleoside derivatives for the treatment of liver diseases
|
KR102754341B1
(ko)
|
2016-11-23 |
2025-01-13 |
케모센트릭스, 인크. |
국소 분절 사구체경화증의 치료 방법
|
AU2018212788A1
(en)
|
2017-01-27 |
2019-07-25 |
Janssen Biotech, Inc. |
Cyclic dinucleotides as STING agonists
|
CN110234404A
(zh)
|
2017-01-27 |
2019-09-13 |
詹森生物科技公司 |
作为sting激动剂的环状二核苷酸
|
CA3044658A1
(en)
|
2017-02-08 |
2018-08-16 |
Eisai R&D Management Co., Ltd. |
Tumor-treating pharmaceutical composition
|
US20190388407A1
(en)
|
2017-02-12 |
2019-12-26 |
Aiviva Biopharma, Inc. |
Multikinase inhibitors of vegf and tfg beta and uses thereof
|
JP6803410B2
(ja)
*
|
2017-02-14 |
2020-12-23 |
富士フイルム株式会社 |
インダゾール化合物の製造方法およびインダゾール化合物
|
US11466047B2
(en)
|
2017-05-12 |
2022-10-11 |
Merck Sharp & Dohme Llc |
Cyclic di-nucleotide compounds as sting agonists
|
RU2019134940A
(ru)
|
2017-05-16 |
2021-06-16 |
Эйсай Ар Энд Ди Менеджмент Ко., Лтд. |
Лечение гепатоцеллюлярной карциномы
|
CN108947970B
(zh)
*
|
2017-05-18 |
2022-04-05 |
四川大学 |
吲唑类衍生物及其制备方法和用途
|
AR111960A1
(es)
|
2017-05-26 |
2019-09-04 |
Incyte Corp |
Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
|
WO2019027858A1
(en)
|
2017-08-04 |
2019-02-07 |
Merck Sharp & Dohme Corp. |
BENZO [B] STING THIOPHEN AGONISTS FOR THE TREATMENT OF CANCER
|
JP2020529421A
(ja)
|
2017-08-04 |
2020-10-08 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
がんの処置のためのPD−1アンタゴニストおよびベンゾ[b]チオフェンSTINGアゴニストの組み合わせ
|
CN111050750B
(zh)
|
2017-08-24 |
2024-09-24 |
诺和诺德股份有限公司 |
Glp-1组合物及其用途
|
EP3681879A1
(en)
|
2017-09-11 |
2020-07-22 |
Krouzon Pharmaceuticals, Inc. |
Octahydrocyclopenta[c]pyrrole allosteric inhibitors of shp2
|
US11052065B2
(en)
|
2017-09-27 |
2021-07-06 |
Merck Sharp & Dohme Corp. |
Compositions and methods for treating cancer with a combination of programmed death receptor (PD-1) antibodies and a CXCR2 antagonist
|
SG11202002975YA
(en)
|
2017-10-11 |
2020-04-29 |
Chemocentryx Inc |
Treatment of focal segmental glomerulosclerosis with ccr2 antagonists
|
WO2019089412A1
(en)
|
2017-11-01 |
2019-05-09 |
Merck Sharp & Dohme Corp. |
Novel substituted tetrahydroquinolin compounds as indoleamine 2,3-dioxygenase (ido) inhibitors
|
WO2019099294A1
(en)
|
2017-11-14 |
2019-05-23 |
Merck Sharp & Dohme Corp. |
Novel substituted biaryl compounds as indoleamine 2,3-dioxygenase (ido) inhibitors
|
MX2020004930A
(es)
|
2017-11-14 |
2020-08-27 |
Merck Sharp & Dohme |
Compuestos de biarilo sustituido novedosos como inhibidores de indolamina 2,3-dioxigenasa (ido).
|
BR112020010941A2
(pt)
|
2017-12-15 |
2020-11-17 |
Janssen Biotech, Inc. |
dinucleotídeos cíclicos como agonistas de sting
|
US11685761B2
(en)
|
2017-12-20 |
2023-06-27 |
Merck Sharp & Dohme Llc |
Cyclic di-nucleotide compounds as sting agonists
|
US12215116B2
(en)
|
2018-03-13 |
2025-02-04 |
Merck Sharp & Dohme Llc |
Arginase inhibitors and methods of use
|
CN111971277B
(zh)
|
2018-04-03 |
2023-06-06 |
默沙东有限责任公司 |
作为sting激动剂的苯并噻吩及相关化合物
|
EP3774765A4
(en)
|
2018-04-03 |
2021-12-29 |
Merck Sharp & Dohme Corp. |
Aza-benzothiophene compounds as sting agonists
|
AU2019262579B2
(en)
|
2018-05-04 |
2024-09-12 |
Incyte Corporation |
Salts of an FGFR inhibitor
|
SI3788047T1
(sl)
|
2018-05-04 |
2024-11-29 |
Incyte Corporation |
Trdne oblike inhibitorja fgfr in postopki priprave le-teh
|
CN110452176A
(zh)
*
|
2018-05-07 |
2019-11-15 |
四川大学 |
吲唑类衍生物及其制备方法和用途
|
EP3810116B1
(en)
|
2018-05-31 |
2023-11-15 |
Merck Sharp & Dohme LLC |
Novel substituted [1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors
|
US11274111B2
(en)
|
2018-06-20 |
2022-03-15 |
Merck Sharp & Dohme Corp. |
Arginase inhibitors and methods of use
|
EP3810132A4
(en)
|
2018-06-25 |
2022-06-22 |
Dana-Farber Cancer Institute, Inc. |
TAIRE FAMILY KINASE INHIBITORS AND RELATED USES
|
TWI827677B
(zh)
|
2018-09-18 |
2024-01-01 |
美商尼坎醫療公司 |
作為src同源-2磷酸酶抑制劑之稠合三環衍生物
|
EP3856349A1
(en)
|
2018-09-25 |
2021-08-04 |
Black Diamond Therapeutics, Inc. |
Tyrosine kinase inhibitor compositions, methods of making and methods of use
|
CA3113241A1
(en)
|
2018-09-25 |
2020-04-02 |
Black Diamond Therapeutics, Inc. |
Quinazoline derivatives as tyrosine kinase inhibitor, compositions, methods of making them and their use
|
EP4282416A3
(en)
|
2018-09-29 |
2024-03-06 |
Novartis AG |
Process of manufacture of a compound for inhibiting the activity of shp2
|
WO2020092183A1
(en)
|
2018-11-01 |
2020-05-07 |
Merck Sharp & Dohme Corp. |
Novel substituted pyrazole compounds as indoleamine 2,3-dioxygenase inhibitors
|
US12065438B2
(en)
|
2018-11-06 |
2024-08-20 |
Merck Sharp & Dohme Llc |
Substituted tricyclic compounds as indoleamine 2,3-dioxygenase inhibitors
|
CN111205227A
(zh)
*
|
2018-11-22 |
2020-05-29 |
四川大学 |
3-乙烯基吲唑类衍生物及其制备方法和用途
|
EP3886845B1
(en)
|
2018-11-28 |
2024-09-04 |
Merck Sharp & Dohme LLC |
Novel substituted piperazine amide compounds as indoleamine 2, 3-dioxygenase (ido) inhibitors
|
US12240867B2
(en)
|
2018-12-18 |
2025-03-04 |
Merck Sharp & Dohme Llc |
Arginase inhibitors and methods of use
|
WO2020140098A1
(en)
|
2018-12-28 |
2020-07-02 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 and uses thereof
|
JP7532385B2
(ja)
*
|
2019-01-31 |
2024-08-13 |
杏林製薬株式会社 |
15-pgdh阻害薬
|
US11628162B2
(en)
|
2019-03-08 |
2023-04-18 |
Incyte Corporation |
Methods of treating cancer with an FGFR inhibitor
|
US12281109B2
(en)
|
2019-04-04 |
2025-04-22 |
Merck Sharp & Dohme Llc |
Inhibitors of histone deacetylase-3 useful for the treatment of cancer, inflammation, neurodegeneration diseases and diabetes
|
CA3133803A1
(en)
|
2019-04-11 |
2020-10-15 |
Angion Biomedica Corp. |
Solid forms of (e)-3-[2-(2-thienyl)vinyl]-1h-pyrazole
|
ES2982700T3
(es)
|
2019-04-18 |
2024-10-17 |
Synthon Bv |
Proceso para preparar axitinib, proceso para purificar el producto intermedio 2-((3-yodo-1H-indazol-6-il)tio)-n-metilbenzamida, proceso para purificar axitinib a través de la sal HCI de axitinib, forma sólida de la sal HCI de axitinib
|
US12290601B2
(en)
|
2019-05-09 |
2025-05-06 |
Synthon B.V. |
Pharmaceutical composition comprising axitinib
|
EP3990635A1
(en)
|
2019-06-27 |
2022-05-04 |
Rigontec GmbH |
Design method for optimized rig-i ligands
|
US11591329B2
(en)
|
2019-07-09 |
2023-02-28 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
US11155567B2
(en)
|
2019-08-02 |
2021-10-26 |
Mersana Therapeutics, Inc. |
Sting agonist compounds and methods of use
|
CA3150701A1
(en)
|
2019-08-15 |
2021-02-18 |
Black Diamond Therapeutics, Inc. |
Alkynyl quinazoline compounds
|
CN112442010B
(zh)
*
|
2019-08-30 |
2023-10-03 |
润佳(苏州)医药科技有限公司 |
一类前药化合物及其在治疗癌症方面的应用
|
CN112442011B
(zh)
*
|
2019-08-30 |
2023-11-14 |
润佳(苏州)医药科技有限公司 |
一种前药化合物及其在治疗癌症方面的应用
|
WO2021035360A1
(en)
*
|
2019-08-30 |
2021-03-04 |
Risen (Suzhou) Pharma Tech Co., Ltd. |
Prodrugs of the tyrosine kinase inhibitor for treating cancer
|
WO2021067374A1
(en)
|
2019-10-01 |
2021-04-08 |
Incyte Corporation |
Bicyclic heterocycles as fgfr inhibitors
|
KR20220100879A
(ko)
|
2019-10-14 |
2022-07-18 |
인사이트 코포레이션 |
Fgfr 저해제로서의 이환식 헤테로사이클
|
US11566028B2
(en)
|
2019-10-16 |
2023-01-31 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
CN112694474B
(zh)
*
|
2019-10-23 |
2022-03-18 |
四川大学 |
吲唑类衍生物及其制备方法和用途
|
PE20221504A1
(es)
|
2019-12-04 |
2022-09-30 |
Incyte Corp |
Derivados de un inhibidor de fgfr
|
EP4069696A1
(en)
|
2019-12-04 |
2022-10-12 |
Incyte Corporation |
Tricyclic heterocycles as fgfr inhibitors
|
EP4069683A1
(en)
|
2019-12-06 |
2022-10-12 |
Mersana Therapeutics, Inc. |
Dimeric compounds as sting agonists
|
US20220396577A1
(en)
|
2019-12-17 |
2022-12-15 |
Merck Sharp & Dohme Llc |
Novel substituted 1,3-8-triazaspiro[4,5] decane-2,4-dione compounds as indoleamine 2,3-dioxygenase (ido) and/or tryptophan 2,3-dioxygenase (tdo) inhibitors
|
EP4087583A4
(en)
|
2020-01-07 |
2024-01-24 |
Merck Sharp & Dohme LLC |
ARGINASE INHIBITORS AND METHODS OF USE
|
WO2021146424A1
(en)
|
2020-01-15 |
2021-07-22 |
Incyte Corporation |
Bicyclic heterocycles as fgfr inhibitors
|
CN111829859B
(zh)
*
|
2020-01-20 |
2024-01-05 |
北京林业大学 |
一种高效杨树种子透明染色及其三维成像的方法
|
CA3168543A1
(en)
|
2020-01-29 |
2021-08-05 |
Gilead Sciences, Inc. |
Glp-1r modulating compounds
|
US20230082544A1
(en)
|
2020-02-18 |
2023-03-16 |
Novo Nordisk A/S |
Pharmaceutical formulations
|
BR102020005423A2
(pt)
*
|
2020-03-18 |
2021-09-28 |
Faculdades Catolicas |
Compostos n-acil-hidrazônicos, uso no tratamento de agregopatias degenerativas amiloides e não-amiloides, e composição farmacêutica
|
WO2021195206A1
(en)
|
2020-03-24 |
2021-09-30 |
Black Diamond Therapeutics, Inc. |
Polymorphic forms and related uses
|
PH12022552639A1
(en)
|
2020-04-02 |
2024-02-19 |
Mersana Therapeutics Inc |
Antibody drug conjugates comprising sting agonists
|
PE20230680A1
(es)
|
2020-05-06 |
2023-04-21 |
Merck Sharp And Dohme Llc |
Inhibidores de il4i1 y metodos de uso
|
WO2021232367A1
(zh)
*
|
2020-05-21 |
2021-11-25 |
四川大学 |
3-乙烯基吲唑类衍生物及其制备方法和用途
|
CN113943271B
(zh)
*
|
2020-07-15 |
2023-11-14 |
鲁南制药集团股份有限公司 |
一种阿昔替尼晶型及其制备方法
|
CN112028831A
(zh)
*
|
2020-09-24 |
2020-12-04 |
山东大学 |
一种苯并吡唑类化合物、其制备方法及作为抗肿瘤药物的应用
|
US20240051939A1
(en)
*
|
2020-12-08 |
2024-02-15 |
Disarm Therapeutics, Inc. |
Benzopyrazole inhibitors of sarm1
|
IL303661A
(en)
|
2020-12-22 |
2023-08-01 |
Nikang Therapeutics Inc |
Compounds for degrading cyclin-dependent kinase 2 via ubiquitin proteosome pathway
|
WO2022152821A1
(en)
|
2021-01-13 |
2022-07-21 |
Monte Rosa Therapeutics Ag |
Isoindolinone compounds
|
WO2022170052A1
(en)
|
2021-02-05 |
2022-08-11 |
Black Diamond Therapeutics, Inc. |
Quinazoline derivatives, pyridopyrimidine derivatives, pyrimidopyrimidine derivatives, and uses thereof
|
CA3215903A1
(en)
|
2021-04-12 |
2022-10-20 |
Incyte Corporation |
Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent
|
EP4323350A1
(en)
|
2021-04-14 |
2024-02-21 |
Monte Rosa Therapeutics AG |
Isoindolinone compounds
|
WO2022219412A1
(en)
|
2021-04-14 |
2022-10-20 |
Monte Rosa Therapeutics Ag |
Isoindolinone amide compounds useful to treat diseases associated with gspt1
|
WO2022227015A1
(en)
|
2021-04-30 |
2022-11-03 |
Merck Sharp & Dohme Corp. |
Il4i1 inhibitors and methods of use
|
CA3220274A1
(en)
|
2021-06-09 |
2022-12-15 |
Incyte Corporation |
Tricyclic heterocycles as fgfr inhibitors
|
EP4370522A1
(en)
|
2021-07-14 |
2024-05-22 |
Nikang Therapeutics, Inc. |
Alkylidene derivatives as kras inhibitors
|
CN115701423B
(zh)
*
|
2021-08-02 |
2025-03-25 |
沈阳化工大学 |
三氟乙基硫醚(亚砜)取代苯类化合物的制备方法及其中间体
|
MX2024011545A
(es)
|
2022-03-23 |
2024-09-26 |
Ideaya Biosciences Inc |
Compuestos de indazol sustituidos con piperazina como inhibidores de parg.
|
US12331026B2
(en)
|
2022-03-28 |
2025-06-17 |
Nikang Therapeutics, Inc. |
Sulfonamido derivatives as cyclin-dependent kinase 2 inhibitors
|
EP4282415A1
(en)
|
2022-05-26 |
2023-11-29 |
Genepharm S.A. |
A stable tablet composition of axitinib
|
EP4536363A1
(en)
|
2022-06-08 |
2025-04-16 |
Nikang Therapeutics, Inc. |
Sulfamide derivatives as cyclin-dependent kinase 2 inhibitors
|
EP4556466A1
(en)
*
|
2022-08-08 |
2025-05-21 |
Beyang Therapeutics Co., Ltd. |
Protein tyrosine kinase inhibitor and medical use thereof
|
AU2023375457A1
(en)
|
2022-11-11 |
2025-05-01 |
Nikang Therapeutics, Inc. |
Bifunctional compounds containing 2,5-substituted pyrimidine derivatives for degrading cyclin-dependent kinase 2 via ubiquitin proteasome pathway
|
US20240336608A1
(en)
|
2023-03-29 |
2024-10-10 |
Merck Sharp & Dohme Llc |
Il4i1 inhibitors and methods of use
|
WO2025072462A1
(en)
|
2023-09-27 |
2025-04-03 |
Nikang Therapeutics, Inc. |
Sulfonamide derivatives as cyclin-dependent kinase 2 inhibitors
|
WO2025082316A1
(zh)
*
|
2023-10-17 |
2025-04-24 |
苏州必扬医药科技有限公司 |
一种眼用制剂及其制备方法和应用
|
WO2025117616A1
(en)
|
2023-11-27 |
2025-06-05 |
Nikang Therapeutics, Inc. |
Bifunctional compounds containing 2,5-substituted pyrimidine derivatives for degrading cyclin-dependent kinase 2 and cyclin-dependent kinase 4 via ubiquitin proteasome pathway
|
WO2025117981A1
(en)
|
2023-12-02 |
2025-06-05 |
Nikang Therapeutics, Inc. |
Bifunctional compounds containing 2,5-substituted pyrimidine derivatives for degrading cyclin-dependent kinase 2 via ubiquitin proteasome pathway
|