AR035554A1 - Compuesto derivado de indazol, composicion farmaceutica que lo comprende y su uso en la fabricacion de medicamentos para modular la actividad de quinasa proteina. - Google Patents

Compuesto derivado de indazol, composicion farmaceutica que lo comprende y su uso en la fabricacion de medicamentos para modular la actividad de quinasa proteina.

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Publication number
AR035554A1
AR035554A1 ARP000103381A ARP000103381A AR035554A1 AR 035554 A1 AR035554 A1 AR 035554A1 AR P000103381 A ARP000103381 A AR P000103381A AR P000103381 A ARP000103381 A AR P000103381A AR 035554 A1 AR035554 A1 AR 035554A1
Authority
AR
Argentina
Prior art keywords
heteroaryl
aryl
substituted
unsubstituted
modulate
Prior art date
Application number
ARP000103381A
Other languages
English (en)
Inventor
Michael David Johnson
Robert Steven Kania
Cynthia Louise Palmer
Siegfried H Reich
Anna Maria Tempczyk-Russell
Michael Brennan Wallace
John F Braganza
Hiep The Luu
Stephan James Cripps
Christine Thomas
Michael David Varney
Steven Lee Bender
Allen J Borchardt
Ye Hua
Min Teng
Theodore Otto Johnson Jr
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22498654&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR035554(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Agouron Pharma filed Critical Agouron Pharma
Publication of AR035554A1 publication Critical patent/AR035554A1/es

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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compuesto derivado de indazol, de fórmula (1), donde: R1 es un arilo o heteroarilo, sustituido o no sustituido, o un grupo de la fórmula CH=CH-R3 o CH=N-R3 donde R3 es un alquilo, alquenilo, cicloalquilo, heterocicloalquilo, arilo, o heteroarilo, sustituido o no sustituido; y R2 es un arilo o heteroarilo sustituido o no sustituido, o Y-X, donde Y es O, S, C=CH2, C=O, S=O, SO2, alquilideno, NH, o N-(C1-8 alquilo), y X es Ar sustituido o no sustituido, heteroarilo, NH-(alquilo), NH-(cicloalquilo), NH-(heterocicloalquilo), NH(arilo, NH-(heteroarilo), NH-(alcoxilo), o NH-(dialquiloamida), donde Ar es arilo; o una prodroga farmacéutica aceptable, un metabolito que es activo farmacéuticamente, o una sal que es aceptable farmacéuticamente. Dichos compuestos de indazol modulan y/o inhiben la actividad de ciertas quinasas de proteína. Estos compuestos y las composiciones farmacéuticas que los contienen son capaces de mediar la transducción senalada de quinasa tirosina y así modulan y/o inhiben la proliferación de células superfluas. También se describe el uso de estos compuestos en la fabricación de medicamentos para tratar el cáncer y otras enfermedades asociadas a la angiogénesis superflua y/o la proliferación celular, como retinopatía diabética, glaucoma neovascular, artritis reumatoidea, y psoriasis.
ARP000103381A 1999-07-02 2000-06-30 Compuesto derivado de indazol, composicion farmaceutica que lo comprende y su uso en la fabricacion de medicamentos para modular la actividad de quinasa proteina. AR035554A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14213099P 1999-07-02 1999-07-02

Publications (1)

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AR035554A1 true AR035554A1 (es) 2004-06-16

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ID=22498654

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Application Number Title Priority Date Filing Date
ARP000103381A AR035554A1 (es) 1999-07-02 2000-06-30 Compuesto derivado de indazol, composicion farmaceutica que lo comprende y su uso en la fabricacion de medicamentos para modular la actividad de quinasa proteina.
ARP080101395A AR065937A2 (es) 1999-07-02 2008-04-03 Compuesto derivado indazol, composicion farmaceutica que lo comprende y su uso en la fabricacion de medicamentos para modular la actividad de proteina quinasa

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ARP080101395A AR065937A2 (es) 1999-07-02 2008-04-03 Compuesto derivado indazol, composicion farmaceutica que lo comprende y su uso en la fabricacion de medicamentos para modular la actividad de proteina quinasa

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EP (2) EP1218348B1 (es)
JP (2) JP3878849B2 (es)
KR (1) KR100529639B1 (es)
CN (2) CN1137884C (es)
AP (1) AP1486A (es)
AR (2) AR035554A1 (es)
AT (1) ATE376543T1 (es)
AU (1) AU777701B2 (es)
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Families Citing this family (335)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU228964B1 (en) 1999-02-10 2013-07-29 Astrazeneca Ab Quinazoline derivatives as angiogenesis inhibitors, process for their preparation and medicaments containing them
PE20010306A1 (es) * 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
DZ3377A1 (fr) 1999-12-24 2001-07-05 Aventis Pharma Ltd Azaindoles
EP1268472B1 (en) 2000-02-07 2004-10-13 Bristol-Myers Squibb Company 3-aminopyrazole inhibitors of cyclin dependent kinases
EP1264820A4 (en) * 2000-03-14 2004-09-15 Fujisawa Pharmaceutical Co amide compounds
JP2004507455A (ja) 2000-04-25 2004-03-11 ブリストル−マイヤーズ　スクイブ　カンパニー サイクリン依存性キナーゼ阻害剤としての、５−チオ−、スルフィニル−およびスルホニルピラゾロ［３，４−ｂ］−ピリジンの用途
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