AR030211A1 - Compuestos derivados de amino-pirazol, composicion farmaceutica que lo comprende y su uso en el tratamiento de enfermedades mediadas por la actividad de la quinasa proteinica - Google Patents
Compuestos derivados de amino-pirazol, composicion farmaceutica que lo comprende y su uso en el tratamiento de enfermedades mediadas por la actividad de la quinasa proteinicaInfo
- Publication number
- AR030211A1 AR030211A1 ARP010101823A ARP010101823A AR030211A1 AR 030211 A1 AR030211 A1 AR 030211A1 AR P010101823 A ARP010101823 A AR P010101823A AR P010101823 A ARP010101823 A AR P010101823A AR 030211 A1 AR030211 A1 AR 030211A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- substituted
- formula
- activity
- unsubstituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos derivados de amino-pirazol de formula (1) donde R1 es un alquilo, arilo, heteroarilo, cicloalquilo o heterocicloalquilo sustituido o insustituido; R2 es un heteroarilo o heterocicloalquilo sustituido o insustituido; y R3 es hidrogeno, fluor, cloro, bromo, yodo o un alquilo C1-8 sustituido o insustituido, o R2 y R3 juntos forman un anillo arilo, heteroarilo, cicloalquilo o heterocicloalquilo de 5 miembros sustituido o insustituido; o una sal farmacéuticamente aceptable de un compuesto de la formula (1) o una prodroga farmacéuticamente aceptable de un compuesto de la formula (1); o un metabolito farmacéuticamente activo de un compuesto de la formula (1) o una sal farmacéuticamente aceptable de dicho metabolito. Dichos compuestos modulan y/o inhiben la actividad de quinasas proteínicas. Estos compuestos y las composiciones farmacéuticas que los contienen son capaces de mediar y/o inhibir la actividad de quinasas dependientes de la ciclina, por tanto modulando y/o inhibiendo la proliferacion celular indeseada. El invento está también dirigido al uso terapéutico o profiláctico de composiciones farmacéuticas que contienen tales compuestos, y a métodos de tratamiento de cáncer, además de otros estados de enfermedad asociados con angiogénesis indeseada y/o proliferacion celular, tal como retinopatía diabética, glaucoma neovascular, artritis reumática y psoriasis, administrando cantidades eficaces de tales compuestos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19786200P | 2000-04-18 | 2000-04-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR030211A1 true AR030211A1 (es) | 2003-08-13 |
Family
ID=22731040
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010101823A AR030211A1 (es) | 2000-04-18 | 2001-04-18 | Compuestos derivados de amino-pirazol, composicion farmaceutica que lo comprende y su uso en el tratamiento de enfermedades mediadas por la actividad de la quinasa proteinica |
Country Status (13)
Country | Link |
---|---|
US (1) | US6462069B2 (es) |
EP (1) | EP1274706A1 (es) |
JP (1) | JP2004501083A (es) |
AR (1) | AR030211A1 (es) |
AU (1) | AU2001249865A1 (es) |
BR (1) | BR0110302A (es) |
CA (1) | CA2398446A1 (es) |
GT (1) | GT200100061A (es) |
MX (1) | MXPA02010222A (es) |
PA (1) | PA8515701A1 (es) |
PE (1) | PE20020226A1 (es) |
SV (1) | SV2002000376A (es) |
WO (1) | WO2001079198A1 (es) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020150921A1 (en) * | 1996-02-09 | 2002-10-17 | Francis Barany | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
CZ301750B6 (cs) | 1999-12-24 | 2010-06-09 | Aventis Pharma Limited | Bicyklický pyrrolový derivát, jeho použití pri výrobe léciva, farmaceutická kompozice tento derivát obsahující a pro použití pri lécení |
HUP0302669A3 (en) * | 2000-08-31 | 2004-03-29 | Pfizer Prod Inc | Pyrazole derivatives and pharmaceutical compositions containing them for treating diseases comprising abnormal cell growth and neurodegenerative diseases |
US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
MXPA03002294A (es) | 2000-09-15 | 2005-09-08 | Vertex Pharma | Compuestos de pirazol utiles como inhibidores de proteina cinasa. |
EP1345922B1 (en) | 2000-12-21 | 2006-05-31 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US6756374B2 (en) | 2001-01-22 | 2004-06-29 | Hoffmann-La Roche Inc. | Diaminothiazoles having antiproliferative activity |
GB0115109D0 (en) | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
WO2003097609A1 (en) * | 2002-05-15 | 2003-11-27 | Janssen Pharmaceutica N.V. | N-substituted tricyclic 3-aminopyrazoles as pdfg receptor inhibitors |
EP1739087A1 (en) * | 2002-08-02 | 2007-01-03 | Vertex Pharmaceuticals Incorporated | Pyrazole compositions useful as inhibitors of gsk-3 |
JP4733388B2 (ja) * | 2002-08-02 | 2011-07-27 | バーテックス ファーマシューティカルズ インコーポレイテッド | Gsk−3のインヒビターとして有用なピラゾール組成物 |
US7157455B2 (en) | 2003-02-10 | 2007-01-02 | Hoffmann-La Roche Inc. | 4-Aminopyrimidine-5-one derivatives |
BRPI0407618A (pt) * | 2003-02-21 | 2006-02-21 | Pfizer | derivados de tiazole amino substituidos com cicloalquilo contendo n e composições farmacêuticas para inibição da proliferação celular e métodos para a sua utilização |
JP2006519234A (ja) | 2003-02-27 | 2006-08-24 | スミスクライン ビーチャム コーポレーション | 新規化合物 |
FR2854159B1 (fr) * | 2003-04-25 | 2008-01-11 | Aventis Pharma Sa | Nouveaux derives de l'indole, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de kdr |
TWI372050B (en) | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
US20050032869A1 (en) * | 2003-07-08 | 2005-02-10 | Pharmacia Italia S.P.A. | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
KR101204247B1 (ko) * | 2003-07-22 | 2012-11-22 | 아스텍스 테라퓨틱스 리미티드 | 3,4-이치환된 1h-피라졸 화합물 및 그의 시클린 의존성키나제 (cdk) 및 글리코겐 합성효소 키나제-3(gsk-3) 조정제로서 용도 |
WO2005009435A1 (en) * | 2003-07-25 | 2005-02-03 | Pfizer Inc. | Aminopyrazole compounds and use as chk1 inhibitors |
WO2005049579A2 (en) * | 2003-11-13 | 2005-06-02 | Janssen Pharmaceutica N.V. | Immobilized n-substituted tricyclic 3-aminopyrazoles for the identification of biomolecular targets |
GB0326601D0 (en) * | 2003-11-14 | 2003-12-17 | Novartis Ag | Organic compounds |
GB2410947B (en) * | 2004-02-11 | 2008-09-17 | Cambridge Lab Ltd | Pharmaceutical compounds |
US7211576B2 (en) | 2004-04-20 | 2007-05-01 | Hoffmann-La Roche Inc. | Diaminothiazoles |
EP1742921A2 (en) * | 2004-04-21 | 2007-01-17 | AstraZeneca AB | Pyrazole derivatives useful for the treatment of cancer |
US20060035920A1 (en) * | 2004-05-28 | 2006-02-16 | Millennium Pharmaceuticals, Inc. | Chk-1 inhibitors |
US20070254877A1 (en) * | 2004-06-02 | 2007-11-01 | Takada Pharmaceutical Company Limited | Indole Derivative and Use for Treatment of Cancer |
US7405220B2 (en) | 2004-06-09 | 2008-07-29 | Hoffmann-La Roche Inc. | Pyrazolopyrimidines |
US7423051B2 (en) | 2004-07-15 | 2008-09-09 | Hoffmann-La Roche Inc. | 2,6-diaminopyridine derivatives |
US7423053B2 (en) | 2004-07-15 | 2008-09-09 | Hoffmann-La Roche Inc. | 4-Aminothiazole derivatives |
JP2008520713A (ja) * | 2004-11-17 | 2008-06-19 | ミイカナ セラピューティクス インコーポレイテッド | キナーゼ阻害剤 |
AU2005321091B2 (en) | 2004-12-30 | 2012-04-12 | Astex Therapeutics Limited | Pyrazole compounds that modulate the activity of CDK, GSK and Aurora kinases |
WO2006070198A1 (en) * | 2004-12-30 | 2006-07-06 | Astex Therapeutics Limited | Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases |
WO2006101454A1 (en) * | 2005-03-21 | 2006-09-28 | S*Bio Pte Ltd | Benzothiophene derivatives: preparation and pharmaceutical applications |
GB0514501D0 (en) * | 2005-07-14 | 2005-08-24 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
GB0516168D0 (en) * | 2005-08-05 | 2005-09-14 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
ES2535854T3 (es) * | 2005-09-30 | 2015-05-18 | Miikana Therapeutics, Inc. | Compuestos de pirazol sustituidos |
US7705009B2 (en) | 2005-11-22 | 2010-04-27 | Hoffman-La Roche Inc. | 4-aminopyrimidine-5-thione derivatives |
US8399442B2 (en) | 2005-12-30 | 2013-03-19 | Astex Therapeutics Limited | Pharmaceutical compounds |
WO2007089044A1 (ja) * | 2006-02-03 | 2007-08-09 | Sumitomo Chemical Company, Limited | 芳香族化合物の製造方法 |
WO2008001115A2 (en) | 2006-06-29 | 2008-01-03 | Astex Therapeutics Limited | Pharmaceutical combinations of 1-cyclopropyl-3- [3- (5-m0rphoolin-4-ylmethyl-1h-benzoimidazol-2-yl) -lh-1-pyrazol- 4-yl] -urea |
JP2010529193A (ja) * | 2007-06-11 | 2010-08-26 | ミイカナ セラピューティクス インコーポレイテッド | 置換ピラゾール化合物 |
AR071717A1 (es) | 2008-05-13 | 2010-07-07 | Array Biopharma Inc | Pirrolo[2,3-b]piridinas inhibidoras de quinasas chk1 y chk2,composiciones farmaceuticas que las contienen,proceso para prepararlas y uso de las mismas en el tratamiento y prevencion del cancer. |
GB0810857D0 (en) * | 2008-06-13 | 2008-07-23 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
US20110053866A1 (en) * | 2008-08-12 | 2011-03-03 | Biovail Laboratories International (Barbados) S.R.L. | Pharmaceutical compositions |
GB2462611A (en) * | 2008-08-12 | 2010-02-17 | Cambridge Lab | Pharmaceutical composition comprising tetrabenazine |
GB2463452A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof |
GB2463451A (en) | 2008-09-08 | 2010-03-17 | Cambridge Lab | 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia |
GB2463283A (en) * | 2008-09-08 | 2010-03-10 | Cambridge Lab | 3,11b-cis-dihydrotetrabenazine for use in treating asthma |
CN103408540B (zh) * | 2013-08-22 | 2016-05-18 | 中国药科大学 | 2-唑环取代噻吩类plk1抑制剂及其用途及其用途 |
CN108690006B (zh) * | 2017-04-12 | 2022-02-18 | 中国药科大学 | 一类化合物及其在抗aml药物中的用途 |
JP7302794B2 (ja) | 2018-02-07 | 2023-07-04 | コリア リサーチ インスティチュート オブ ケミカル テクノロジー | Tnikを阻害するための化合物及びその医学的使用 |
CN110835334B (zh) * | 2018-08-16 | 2022-10-18 | 中国药科大学 | 吲哚取代唑类化合物及其用途 |
TW202313588A (zh) | 2021-05-27 | 2023-04-01 | 美商無界生物公司 | 檢測點激酶1(chk1)抑制劑及其用途 |
WO2024118564A1 (en) * | 2022-11-29 | 2024-06-06 | Boundless Bio, Inc. | Checkpoint kinase 1 (chk1) inhibitors and uses thereof |
Family Cites Families (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE273062C (de) | 1912-04-19 | 1914-04-20 | Deylen Sohn Firma | Vorrichtung zum Schränken von Plattenzündspänen |
CH575397A5 (es) | 1971-11-09 | 1976-05-14 | Basf Ag | |
EP0218728A1 (en) | 1985-04-03 | 1987-04-22 | Yamanouchi Pharmaceutical Co. Ltd. | Phenylene derivatives |
JPH083564B2 (ja) | 1986-07-25 | 1996-01-17 | 三菱化学株式会社 | 偏光フィルム |
DD273062A1 (de) | 1988-06-14 | 1989-11-01 | Fahlberg List Veb | Verfahren zur herstellung von hydroxybenzoesaeure(chinoxalin-2-ylmethyl)-ethern und -estern |
CA1330079C (en) * | 1988-10-13 | 1994-06-07 | Michihiko Tsujitani | Pyrrolo (3,2-e)pyrazolo(1,5-a)pyrimidine derivative and medicine comprising the same |
CA2102780C (en) | 1991-05-10 | 2007-01-09 | Alfred P. Spada | Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase |
CA2130196A1 (en) | 1992-03-24 | 1993-09-30 | Jose Luis Castro Pineiro | Benzodiazepine derivatives |
US5612360A (en) | 1992-06-03 | 1997-03-18 | Eli Lilly And Company | Angiotensin II antagonists |
AU5704594A (en) | 1992-12-18 | 1994-07-19 | Wellcome Foundation Limited, The | Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors |
US5625031A (en) | 1994-02-08 | 1997-04-29 | Bristol-Myers Squibb Company | Peptide inhibitors of the p33cdk2 and p34cdc2 cell cycle regulatory kinases and human papillomavirus E7 oncoprotein |
US5631156A (en) | 1994-06-21 | 1997-05-20 | The University Of Michigan | DNA encoding and 18 KD CDK6 inhibiting protein |
DE69532817T2 (de) * | 1994-11-10 | 2005-01-13 | Millenium Pharmaceuticals, Inc., Cambridge | Verwendung von pyrazole verbindungen zur behandlung von glomerulonephritis, krebs, atherosklerose oder restenose |
KR19980701879A (ko) | 1995-02-02 | 1998-06-25 | 피터 기딩스 | 5-히드록시트립타민 수용체 길항제로서의 인돌 유도체 |
US5710173A (en) | 1995-06-07 | 1998-01-20 | Sugen, Inc. | Thienyl compounds for inhibition of cell proliferative disorders |
AU6526896A (en) | 1995-07-22 | 1997-02-18 | Rhone-Poulenc Rorer Limited | Substituted aromatic compounds and their pharmaceutical use |
US5846990A (en) * | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
US5705499A (en) | 1995-10-06 | 1998-01-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | 8-arylalkyl- and 8-arylheteroalkyl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-e! 1!diazepines and their use in the treatment of HIV-1 infection |
US5733920A (en) | 1995-10-31 | 1998-03-31 | Mitotix, Inc. | Inhibitors of cyclin dependent kinases |
US5760028A (en) | 1995-12-22 | 1998-06-02 | The Dupont Merck Pharmaceutical Company | Integrin receptor antagonists |
US6495526B2 (en) | 1996-01-23 | 2002-12-17 | Gpc Biotech, Inc. | Inhibitors of cell-cycle progression and uses related thereto |
WO1997034876A1 (en) | 1996-03-15 | 1997-09-25 | Zeneca Limited | Cinnoline derivatives and use as medicine |
GB9608435D0 (en) | 1996-04-24 | 1996-06-26 | Celltech Therapeutics Ltd | Chemical compounds |
US5849733A (en) | 1996-05-10 | 1998-12-15 | Bristol-Myers Squibb Co. | 2-thio or 2-oxo flavopiridol analogs |
EP0816357B1 (en) | 1996-06-27 | 2002-01-09 | Pfizer Inc. | Substituted indazole derivatives |
FR2750862B1 (fr) | 1996-07-12 | 1998-10-16 | Dupin Jean Pierre | Utilisation d'heterocycles diazotes fusionnes avec un systeme aromatique ou heteroaromatique pour le traitement des maladies thrombo-emboliques |
US5821243A (en) | 1996-07-22 | 1998-10-13 | Viropharma Incorporated | Compounds compositions and methods for treating influenza |
BR9712005A (pt) | 1996-09-04 | 1999-08-24 | Pfizer | Derivados de indazol e seus usos como inibidores de fosfodiesterase (pde) tipo IV e produ-Æo do fator de necrose de tumor (tnf) |
ID18494A (id) | 1996-10-02 | 1998-04-16 | Novartis Ag | Turunan pirazola leburan dan proses pembuatannya |
GB9621757D0 (en) | 1996-10-18 | 1996-12-11 | Ciba Geigy Ag | Phenyl-substituted bicyclic heterocyclyl derivatives and their use |
WO1998033798A2 (en) | 1997-02-05 | 1998-08-06 | Warner Lambert Company | Pyrido[2,3-d]pyrimidines and 4-amino-pyrimidines as inhibitors of cell proliferation |
AU6230098A (en) | 1997-02-27 | 1998-09-18 | Tanabe Seiyaku Co., Ltd. | Isoquinolinone derivatives, process for preparing the same, and their use as phosphodiesterase inhibitors |
CA2294244A1 (en) | 1997-07-12 | 1999-01-21 | Cancer Research Campaign Technology Limited | Cyclin dependent kinase inhibiting purine derivatives |
GB9716324D0 (en) | 1997-08-01 | 1997-10-08 | Mead Corp | Packaging machine and method of carton set up |
FR2767827A1 (fr) | 1997-09-03 | 1999-02-26 | Adir | Nouveaux derives de l'indole et de l'indazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
AU9691198A (en) | 1997-10-06 | 1999-04-27 | Basf Aktiengesellschaft | Indeno{1,2-c}-, naphtho{1,2-c}- and benzo{6,7}cyclohepta{1,2-c}pyrazole derivatives |
BR9815200A (pt) | 1997-10-27 | 2001-10-16 | Agouron Pharma | Composto, composição farmacêutica e método de tratamento de uma doença ou distúrbio mediado pela inibição de cdk4 ou um complexo de cdk4/ciclina |
IL135900A0 (en) | 1997-11-04 | 2001-05-20 | Pfizer Prod Inc | Indazole bioisostere replacement of catechol in therapeuticaly active compounds |
NZ503995A (en) | 1997-11-04 | 2003-02-28 | Pfizer Prod Inc | Indazole compounds, and pharmaceutical compositions and uses thereof, based on indazole bioisostere replacement of catechol in PDE4 inhibitors |
US6040321A (en) | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
HUP0100931A3 (en) | 1998-02-26 | 2002-08-28 | Aventis Pharma Inc | 6,9-disubstituted 2-[trans-(-aminocyclohexyl)amino]purines and pharmaceutical compositions containing them |
US6479487B1 (en) | 1998-02-26 | 2002-11-12 | Aventis Pharmaceuticals Inc. | 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines |
EA003603B1 (ru) | 1998-02-27 | 2003-06-26 | Пфайзер Продактс Инк. | N-[(замещенное пятичленное ди- или триазадиненасыщенное кольцо) карбонил] гуанидиновые производные для лечения ишемии |
JP4665239B2 (ja) | 1998-04-21 | 2011-04-06 | アゲンニクス アーゲー | 抗癌剤および抗増殖性薬剤としての5−アミノインデノ[1,2−c]ピラゾール−4−オン |
ATE288904T1 (de) | 1998-06-18 | 2005-02-15 | Bristol Myers Squibb Co | Durch kohlenstoff substituierte aminothiazole als inhibitoren von zyclin-abhägigen kinasen |
UA72749C2 (en) | 1998-09-29 | 2005-04-15 | White Holdings Corp | Substituted 3-cyanoquinolines, a method for the preparation thereof (variants), pharmaceutical composition based thereon, a method for the treatment, inhibiting the growth or elimination of neoplasms and a method for the treatment, inhibiting progressing or elimination of polycystic kidney disease using them |
EP1189609A4 (en) * | 1999-05-03 | 2002-10-30 | Smithkline Beecham Corp | CXCR-4 RECEPTOR ANTAGONISTS AND THROMBOPOIETIN MIMETIKA |
-
2001
- 2001-04-05 WO PCT/US2001/010997 patent/WO2001079198A1/en active Application Filing
- 2001-04-05 AU AU2001249865A patent/AU2001249865A1/en not_active Abandoned
- 2001-04-05 CA CA002398446A patent/CA2398446A1/en not_active Abandoned
- 2001-04-05 MX MXPA02010222A patent/MXPA02010222A/es active IP Right Grant
- 2001-04-05 JP JP2001576797A patent/JP2004501083A/ja not_active Withdrawn
- 2001-04-05 EP EP01923144A patent/EP1274706A1/en not_active Withdrawn
- 2001-04-05 BR BR0110302-4A patent/BR0110302A/pt not_active IP Right Cessation
- 2001-04-06 SV SV2001000376A patent/SV2002000376A/es unknown
- 2001-04-11 PE PE2001000337A patent/PE20020226A1/es not_active Application Discontinuation
- 2001-04-17 US US09/835,566 patent/US6462069B2/en not_active Expired - Fee Related
- 2001-04-17 GT GT200100061A patent/GT200100061A/es unknown
- 2001-04-17 PA PA20018515701A patent/PA8515701A1/es unknown
- 2001-04-18 AR ARP010101823A patent/AR030211A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2001079198A9 (en) | 2002-05-16 |
WO2001079198A1 (en) | 2001-10-25 |
CA2398446A1 (en) | 2001-10-25 |
JP2004501083A (ja) | 2004-01-15 |
PA8515701A1 (es) | 2002-02-21 |
WO2001079198B1 (en) | 2002-06-13 |
US20020006952A1 (en) | 2002-01-17 |
MXPA02010222A (es) | 2003-05-23 |
GT200100061A (es) | 2002-03-14 |
AU2001249865A1 (en) | 2001-10-30 |
PE20020226A1 (es) | 2002-04-02 |
EP1274706A1 (en) | 2003-01-15 |
BR0110302A (pt) | 2003-01-14 |
US6462069B2 (en) | 2002-10-08 |
SV2002000376A (es) | 2002-12-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR030211A1 (es) | Compuestos derivados de amino-pirazol, composicion farmaceutica que lo comprende y su uso en el tratamiento de enfermedades mediadas por la actividad de la quinasa proteinica | |
MA58004B1 (fr) | Dérivés de pyrazolyle utiles en tant qu'agents anticancéreux | |
AR035554A1 (es) | Compuesto derivado de indazol, composicion farmaceutica que lo comprende y su uso en la fabricacion de medicamentos para modular la actividad de quinasa proteina. | |
AR032438A1 (es) | Compuesto derivado de indazol, composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento para tratar enfermedades proteinquinasa dependientes | |
ECSP066335A (es) | Compuestos de indazol 3,5-disustituidos, composiciones farmacéuticas y métodos para intervenir en o inhibir la proliferación celular | |
AR042510A1 (es) | Compuestos de indazol y composiciones farmaceuticas para inhibir proteinquinasas y procedimientos para su uso | |
AR046297A1 (es) | Inhibidores de la dpp - iv metodos para prepararlos y composiciones farmaceuticas que los contienen como agente activo | |
EA200401613A1 (ru) | Лекарственное средство для лечения рака | |
GT200100014A (es) | Compuestos de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo. | |
EA200200708A1 (ru) | Производные бензазола и их применение в качестве модуляторов jnk | |
BRPI0114704B8 (pt) | composto de imidazol fundido a arila ou heteroarila, suas composições farmacêuticas, bem como seu uso | |
AR035374A1 (es) | Un derivado de fenilacetamido-pirazol, su uso, un procedimiento para su preparacion, una composicion farmaceutica que lo comprende, un kit que comprende dicho derivado o composicion, un metodo para tratar desordenes proliferativos celularaes asociados con una actividad quinasa dependiente de ciclo c | |
EP2968233A1 (en) | Histone deacetylase inhibitors and compositions and methods of use thereof | |
EA200001061A1 (ru) | Фармацевтическая композиция | |
AR032763A1 (es) | Compuestos pirazol-tiazol, composicion farmaceutica que lo contiene, y el uso de dicho compuesto en la fabricacion de medicamentos para inhibir quinasas ciclino-dependientes | |
WO2016179554A1 (en) | Histone deacetylase inhibitors and compositions and methods of use thereof | |
CO2023002940A2 (es) | Derivados de espiropiperidinilo sustituidos con heteroarilo y usos farmacéuticos de los mismos | |
AR101566A2 (es) | Composición farmacéutica de compuestos heterobicíclicos que contienen nitrógeno | |
DE60011110D1 (de) | Pharmazeutisch wirksame sulfonyl hydrazid-derivate | |
DK0780125T3 (da) | Anvendelse af hydantoinderivater til fremstilling af et lægemiddel til behandling af sygdomme associeret med tilstedeværelse af aktivt oxygen og frie radikaler | |
DK1242406T3 (da) | Hidtil ukendte forbindelser | |
MX9405111A (es) | Nuevos derivados de (1-fenil-1-heterociclil)metanol y(1-fenil-1-heterociclil-metilamina). | |
CA2366829A1 (fr) | Nouveaux derives de morpholine, procede pour leur preparation et compositions pharmaceutiques les contenant | |
AR055108A1 (es) | Derivados de fenilpiridina, su obtencion y su utilizacion en composiciones farmaceuticas para el tratamiento del cancer. | |
GT200100170A (es) | Compuestos con nucleos heterocicliclo-hidroximino-fluoreno y las composiciones farmaceuticas para la inhibicion delasproteinas quinasas y los metodos para su uso. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |