AU2001249865A1 - Pyrazoles for inhibiting protein kinase - Google Patents
Pyrazoles for inhibiting protein kinaseInfo
- Publication number
- AU2001249865A1 AU2001249865A1 AU2001249865A AU4986501A AU2001249865A1 AU 2001249865 A1 AU2001249865 A1 AU 2001249865A1 AU 2001249865 A AU2001249865 A AU 2001249865A AU 4986501 A AU4986501 A AU 4986501A AU 2001249865 A1 AU2001249865 A1 AU 2001249865A1
- Authority
- AU
- Australia
- Prior art keywords
- pyrazoles
- protein kinase
- inhibiting protein
- inhibiting
- kinase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19786200P | 2000-04-18 | 2000-04-18 | |
US60197862 | 2000-04-18 | ||
PCT/US2001/010997 WO2001079198A1 (en) | 2000-04-18 | 2001-04-05 | Pyrazoles for inhibiting protein kinase |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001249865A1 true AU2001249865A1 (en) | 2001-10-30 |
Family
ID=22731040
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001249865A Abandoned AU2001249865A1 (en) | 2000-04-18 | 2001-04-05 | Pyrazoles for inhibiting protein kinase |
Country Status (13)
Country | Link |
---|---|
US (1) | US6462069B2 (en) |
EP (1) | EP1274706A1 (en) |
JP (1) | JP2004501083A (en) |
AR (1) | AR030211A1 (en) |
AU (1) | AU2001249865A1 (en) |
BR (1) | BR0110302A (en) |
CA (1) | CA2398446A1 (en) |
GT (1) | GT200100061A (en) |
MX (1) | MXPA02010222A (en) |
PA (1) | PA8515701A1 (en) |
PE (1) | PE20020226A1 (en) |
SV (1) | SV2002000376A (en) |
WO (1) | WO2001079198A1 (en) |
Families Citing this family (53)
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US20020150921A1 (en) * | 1996-02-09 | 2002-10-17 | Francis Barany | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
CZ301751B6 (en) | 1999-12-24 | 2010-06-09 | Aventis Pharma Limited | Bicyclic pyrrole derivative, pharmaceutical composition in which the derivative is comprised, the composition for use in therapy and use of the derivative when preparing a medicament |
EA200300205A1 (en) * | 2000-08-31 | 2003-06-26 | Пфайзер Продактс Инк. | DERIVATIVES OF PYRAZOL AND THEIR APPLICATION AS PROTEINKINASE INHIBITORS |
US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
CA2422354C (en) | 2000-09-15 | 2009-12-08 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
NZ526469A (en) | 2000-12-21 | 2005-10-28 | Vertex Pharma | Pyrazole compounds useful as protein kinase inhibitors |
US6756374B2 (en) | 2001-01-22 | 2004-06-29 | Hoffmann-La Roche Inc. | Diaminothiazoles having antiproliferative activity |
GB0115109D0 (en) | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
RS98804A (en) * | 2002-05-15 | 2006-10-27 | Janssen Pharmaceutica N.V. | N-substituted tricyclic 3-aminopyrazoles as pdfg receptor ihhibitors |
SI1532145T1 (en) * | 2002-08-02 | 2007-02-28 | Vertex Pharma | Pyrazole compositions useful as inhibitors of gsk-3 |
CN1319968C (en) * | 2002-08-02 | 2007-06-06 | 沃泰克斯药物股份有限公司 | Compositions useful as inhibitors of GSK-3 |
US7157455B2 (en) | 2003-02-10 | 2007-01-02 | Hoffmann-La Roche Inc. | 4-Aminopyrimidine-5-one derivatives |
CA2516234A1 (en) * | 2003-02-21 | 2004-09-02 | Pfizer Inc. | N-heterocyclyl-substituted amino-thiazole derivatives as protein kinase inhibitors |
DE602004016964D1 (en) | 2003-02-27 | 2008-11-20 | Smithkline Beecham Corp | NEW CONNECTIONS |
FR2854159B1 (en) * | 2003-04-25 | 2008-01-11 | Aventis Pharma Sa | NOVEL INDOLE DERIVATIVES, THEIR PREPARATION AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND IN PARTICULAR AS KDR INHIBITORS |
TWI372050B (en) | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
US20050032869A1 (en) * | 2003-07-08 | 2005-02-10 | Pharmacia Italia S.P.A. | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
KR101204247B1 (en) * | 2003-07-22 | 2012-11-22 | 아스텍스 테라퓨틱스 리미티드 | 3,4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases cdk and glycogen synthase kinase-3 gsk-3 modulators |
CA2532231A1 (en) * | 2003-07-25 | 2005-02-03 | Pfizer Inc. | Aminopyrazole compounds and use as chk1 inhibitors |
WO2005049579A2 (en) * | 2003-11-13 | 2005-06-02 | Janssen Pharmaceutica N.V. | Immobilized n-substituted tricyclic 3-aminopyrazoles for the identification of biomolecular targets |
GB0326601D0 (en) * | 2003-11-14 | 2003-12-17 | Novartis Ag | Organic compounds |
GB2410947B (en) * | 2004-02-11 | 2008-09-17 | Cambridge Lab Ltd | Pharmaceutical compounds |
US7211576B2 (en) | 2004-04-20 | 2007-05-01 | Hoffmann-La Roche Inc. | Diaminothiazoles |
WO2005103010A2 (en) * | 2004-04-21 | 2005-11-03 | Astrazeneca Ab | Pyrazole derivatives useful for the treatment of cancer |
WO2005118583A1 (en) * | 2004-05-28 | 2005-12-15 | Millennium Pharmaceuticals, Inc. | 2, 5-dihydro-pyrazolo`4, 3-c!quinolin-4-ones as chk-1 inhibitors |
EP1761539A1 (en) * | 2004-06-02 | 2007-03-14 | Takeda Pharmaceutical Company Limited | Indole derivative and use for treatment of cancer |
US7405220B2 (en) | 2004-06-09 | 2008-07-29 | Hoffmann-La Roche Inc. | Pyrazolopyrimidines |
US7423053B2 (en) | 2004-07-15 | 2008-09-09 | Hoffmann-La Roche Inc. | 4-Aminothiazole derivatives |
US7423051B2 (en) | 2004-07-15 | 2008-09-09 | Hoffmann-La Roche Inc. | 2,6-diaminopyridine derivatives |
US8153630B2 (en) * | 2004-11-17 | 2012-04-10 | Miikana Therapeutics, Inc. | Kinase inhibitors |
EP1833819A1 (en) * | 2004-12-30 | 2007-09-19 | Astex Therapeutics Limited | Pyrazole compounds that modulate the activity of cdk, gsk and aurora kinases |
US20100160324A1 (en) * | 2004-12-30 | 2010-06-24 | Astex Therapeutics Limited | Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases |
WO2006101454A1 (en) * | 2005-03-21 | 2006-09-28 | S*Bio Pte Ltd | Benzothiophene derivatives: preparation and pharmaceutical applications |
GB0514501D0 (en) * | 2005-07-14 | 2005-08-24 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
GB0516168D0 (en) * | 2005-08-05 | 2005-09-14 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
ES2535854T3 (en) * | 2005-09-30 | 2015-05-18 | Miikana Therapeutics, Inc. | Substituted Pyrazole Compounds |
US7705009B2 (en) | 2005-11-22 | 2010-04-27 | Hoffman-La Roche Inc. | 4-aminopyrimidine-5-thione derivatives |
US8399442B2 (en) | 2005-12-30 | 2013-03-19 | Astex Therapeutics Limited | Pharmaceutical compounds |
CN101410375B (en) * | 2006-02-03 | 2012-06-13 | 住友化学株式会社 | Method for producing aromatic compound |
WO2008001115A2 (en) | 2006-06-29 | 2008-01-03 | Astex Therapeutics Limited | Pharmaceutical combinations of 1-cyclopropyl-3- [3- (5-m0rphoolin-4-ylmethyl-1h-benzoimidazol-2-yl) -lh-1-pyrazol- 4-yl] -urea |
US20090029992A1 (en) * | 2007-06-11 | 2009-01-29 | Agoston Gregory E | Substituted pyrazole compounds |
CL2009001152A1 (en) | 2008-05-13 | 2009-10-16 | Array Biopharma Inc | Compounds derived from n- (4- (nitrogen cycloalkyl-1-yl) -1h-pyrrolo [2,3-b] pyridin-3-yl) amide, kinase inhibitors; Preparation process; pharmaceutical composition; and its use for the treatment of a proliferative disease. |
GB0810857D0 (en) * | 2008-06-13 | 2008-07-23 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
US20110053866A1 (en) * | 2008-08-12 | 2011-03-03 | Biovail Laboratories International (Barbados) S.R.L. | Pharmaceutical compositions |
GB2462611A (en) * | 2008-08-12 | 2010-02-17 | Cambridge Lab | Pharmaceutical composition comprising tetrabenazine |
GB2463452A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof |
GB2463283A (en) * | 2008-09-08 | 2010-03-10 | Cambridge Lab | 3,11b-cis-dihydrotetrabenazine for use in treating asthma |
GB2463451A (en) | 2008-09-08 | 2010-03-17 | Cambridge Lab | 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia |
CN103408540B (en) * | 2013-08-22 | 2016-05-18 | 中国药科大学 | 2-azoles ring substituted thiophene class PLK1 inhibitor and uses thereof and uses thereof |
CN108690006B (en) * | 2017-04-12 | 2022-02-18 | 中国药科大学 | Compound and application thereof in anti-AML (AML) drugs |
WO2019156439A1 (en) | 2018-02-07 | 2019-08-15 | Korea Research Institute Of Chemical Technology | Compounds for inhibiting tnik and medical uses thereof |
CN110835334B (en) * | 2018-08-16 | 2022-10-18 | 中国药科大学 | Indole-substituted azole compound and application thereof |
AU2022282384A1 (en) | 2021-05-27 | 2023-12-14 | Boundless Bio, Inc. | Checkpoint kinase 1 (chk1) inhibitors and uses thereof |
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DE273062C (en) | 1912-04-19 | 1914-04-20 | Deylen Sohn Firma | Device for setting plate ignition chips |
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EP0218728A1 (en) | 1985-04-03 | 1987-04-22 | Yamanouchi Pharmaceutical Co. Ltd. | Phenylene derivatives |
JPH083564B2 (en) | 1986-07-25 | 1996-01-17 | 三菱化学株式会社 | Polarizing film |
DD273062A1 (en) | 1988-06-14 | 1989-11-01 | Fahlberg List Veb | PROCESS FOR PREPARING HYDROXYBENZOESAEURE (CHINOXALIN-2-YLMETHYL) ETHANTS AND ETHERS |
CA1330079C (en) * | 1988-10-13 | 1994-06-07 | Michihiko Tsujitani | Pyrrolo (3,2-e)pyrazolo(1,5-a)pyrimidine derivative and medicine comprising the same |
ES2108120T3 (en) | 1991-05-10 | 1997-12-16 | Rhone Poulenc Rorer Int | MONO- AND BICYCLE BIS ARYLIC AND HETEROARILIC COMPOUNDS INHIBITING EGF AND / OR PDGF TYPHOSINE KINASE. |
AU670431B2 (en) | 1992-03-24 | 1996-07-18 | Merck Sharp & Dohme Limited | 3-ureido substituted benzodiazepin-2-ones having cholecystokinin and/or gastrin antagonistic activity and their use in therapy |
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-
2001
- 2001-04-05 JP JP2001576797A patent/JP2004501083A/en not_active Withdrawn
- 2001-04-05 AU AU2001249865A patent/AU2001249865A1/en not_active Abandoned
- 2001-04-05 WO PCT/US2001/010997 patent/WO2001079198A1/en active Application Filing
- 2001-04-05 EP EP01923144A patent/EP1274706A1/en not_active Withdrawn
- 2001-04-05 BR BR0110302-4A patent/BR0110302A/en not_active IP Right Cessation
- 2001-04-05 MX MXPA02010222A patent/MXPA02010222A/en active IP Right Grant
- 2001-04-05 CA CA002398446A patent/CA2398446A1/en not_active Abandoned
- 2001-04-06 SV SV2001000376A patent/SV2002000376A/en unknown
- 2001-04-11 PE PE2001000337A patent/PE20020226A1/en not_active Application Discontinuation
- 2001-04-17 PA PA20018515701A patent/PA8515701A1/en unknown
- 2001-04-17 GT GT200100061A patent/GT200100061A/en unknown
- 2001-04-17 US US09/835,566 patent/US6462069B2/en not_active Expired - Fee Related
- 2001-04-18 AR ARP010101823A patent/AR030211A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MXPA02010222A (en) | 2003-05-23 |
WO2001079198B1 (en) | 2002-06-13 |
CA2398446A1 (en) | 2001-10-25 |
US20020006952A1 (en) | 2002-01-17 |
PA8515701A1 (en) | 2002-02-21 |
WO2001079198A9 (en) | 2002-05-16 |
PE20020226A1 (en) | 2002-04-02 |
AR030211A1 (en) | 2003-08-13 |
WO2001079198A1 (en) | 2001-10-25 |
EP1274706A1 (en) | 2003-01-15 |
SV2002000376A (en) | 2002-12-02 |
US6462069B2 (en) | 2002-10-08 |
BR0110302A (en) | 2003-01-14 |
JP2004501083A (en) | 2004-01-15 |
GT200100061A (en) | 2002-03-14 |
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