AU2002231166A1 - Pyrazole compounds useful as protein kinase inhibitors - Google Patents

Pyrazole compounds useful as protein kinase inhibitors

Info

Publication number
AU2002231166A1
AU2002231166A1 AU2002231166A AU2002231166A AU2002231166A1 AU 2002231166 A1 AU2002231166 A1 AU 2002231166A1 AU 2002231166 A AU2002231166 A AU 2002231166A AU 2002231166 A AU2002231166 A AU 2002231166A AU 2002231166 A1 AU2002231166 A1 AU 2002231166A1
Authority
AU
Australia
Prior art keywords
protein kinase
kinase inhibitors
compounds useful
pyrazole compounds
pyrazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU2002231166A
Other versions
AU2002231166B2 (en
Inventor
David Bebbington
Jean-Damien Charrier
Julian Golec
Francoise Pierard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Priority claimed from PCT/US2001/049585 external-priority patent/WO2002050066A2/en
Publication of AU2002231166A1 publication Critical patent/AU2002231166A1/en
Application granted granted Critical
Publication of AU2002231166B2 publication Critical patent/AU2002231166B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

AU2002231166A 2000-12-21 2001-12-20 Pyrazole compounds useful as protein kinase inhibitors Ceased AU2002231166B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25788700P 2000-12-21 2000-12-21
US60/257,887 2000-12-21
US28694901P 2001-04-27 2001-04-27
US60/286,949 2001-04-27
PCT/US2001/049585 WO2002050066A2 (en) 2000-12-21 2001-12-20 Pyrazole compounds useful as protein kinase inhibitors

Publications (2)

Publication Number Publication Date
AU2002231166A1 true AU2002231166A1 (en) 2002-09-05
AU2002231166B2 AU2002231166B2 (en) 2008-02-21

Family

ID=26946273

Family Applications (7)

Application Number Title Priority Date Filing Date
AU2002255452A Ceased AU2002255452B2 (en) 2000-12-21 2001-12-19 Pyrazole compounds useful as protein kinase inhibitors
AU2002234047A Abandoned AU2002234047A1 (en) 2000-12-21 2001-12-19 Pyrazole compounds useful as protein kinase inhibitors
AU2001297619A Ceased AU2001297619B2 (en) 2000-12-21 2001-12-19 Pyrazole compounds useful as protein kinase inhibitors
AU2002231166A Ceased AU2002231166B2 (en) 2000-12-21 2001-12-20 Pyrazole compounds useful as protein kinase inhibitors
AU3116602A Pending AU3116602A (en) 2000-12-21 2001-12-20 Pyrazole compounds useful as protein kinase inhibitors
AU2002246754A Ceased AU2002246754B2 (en) 2000-12-21 2001-12-20 Pyrazole compounds useful as protein kinase inhibitors
AU2006201267A Ceased AU2006201267B2 (en) 2000-12-21 2006-03-21 Pyrazole Compounds Useful as Protein Kinase Inhibitors

Family Applications Before (3)

Application Number Title Priority Date Filing Date
AU2002255452A Ceased AU2002255452B2 (en) 2000-12-21 2001-12-19 Pyrazole compounds useful as protein kinase inhibitors
AU2002234047A Abandoned AU2002234047A1 (en) 2000-12-21 2001-12-19 Pyrazole compounds useful as protein kinase inhibitors
AU2001297619A Ceased AU2001297619B2 (en) 2000-12-21 2001-12-19 Pyrazole compounds useful as protein kinase inhibitors

Family Applications After (3)

Application Number Title Priority Date Filing Date
AU3116602A Pending AU3116602A (en) 2000-12-21 2001-12-20 Pyrazole compounds useful as protein kinase inhibitors
AU2002246754A Ceased AU2002246754B2 (en) 2000-12-21 2001-12-20 Pyrazole compounds useful as protein kinase inhibitors
AU2006201267A Ceased AU2006201267B2 (en) 2000-12-21 2006-03-21 Pyrazole Compounds Useful as Protein Kinase Inhibitors

Country Status (28)

Country Link
US (16) US20030105090A1 (en)
EP (10) EP2264028A1 (en)
JP (19) JP4160395B2 (en)
KR (8) KR100909665B1 (en)
CN (6) CN100340555C (en)
AP (2) AP1588A (en)
AR (4) AR040925A1 (en)
AT (9) ATE354573T1 (en)
AU (7) AU2002255452B2 (en)
BR (2) BR0116411A (en)
CA (8) CA2432129C (en)
CY (1) CY1106297T1 (en)
DE (8) DE60119774T2 (en)
DK (3) DK1353916T3 (en)
ES (7) ES2265452T3 (en)
HK (8) HK1059776A1 (en)
HU (5) HUP0400908A3 (en)
IL (8) IL156369A0 (en)
MX (8) MXPA03005606A (en)
MY (1) MY140377A (en)
NO (5) NO328537B1 (en)
NZ (8) NZ526473A (en)
PL (2) PL210066B1 (en)
PT (3) PT1355905E (en)
RU (1) RU2355688C2 (en)
SI (2) SI1355905T1 (en)
TW (2) TWI313269B (en)
WO (8) WO2002057259A2 (en)

Families Citing this family (370)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6982260B1 (en) 1999-11-22 2006-01-03 Warner-Lambert Company Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes
US7473691B2 (en) * 2000-09-15 2009-01-06 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US6660731B2 (en) * 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
ATE326458T1 (en) 2000-09-15 2006-06-15 Vertex Pharma PYRAZOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS
JP4377583B2 (en) * 2000-12-05 2009-12-02 バーテックス ファーマシューティカルズ インコーポレイテッド Inhibitors of C-JUNN terminal kinase (JNK) and other protein kinases
DK1353916T3 (en) * 2000-12-21 2007-01-29 Vertex Pharma Pyrazole Compounds Suitable as Protein Kinase Inhibitors
CA2441492C (en) * 2001-03-23 2011-08-09 Bayer Corporation Rho-kinase inhibitors
AU2002252614B2 (en) 2001-04-10 2006-09-14 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
US7105667B2 (en) * 2001-05-01 2006-09-12 Bristol-Myers Squibb Co. Fused heterocyclic compounds and use thereof
US7138404B2 (en) * 2001-05-23 2006-11-21 Hoffmann-La Roche Inc. 4-aminopyrimidine derivatives
US6939874B2 (en) 2001-08-22 2005-09-06 Amgen Inc. Substituted pyrimidinyl derivatives and methods of use
US7115617B2 (en) 2001-08-22 2006-10-03 Amgen Inc. Amino-substituted pyrimidinyl derivatives and methods of use
WO2003026664A1 (en) * 2001-09-26 2003-04-03 Bayer Corporation 2-phenylamino-4- (5-pyrazolylamino) -pyramidine derivatives as kinase inhibitors, in particular, src kinase inhibitors
EA007430B1 (en) 2001-09-26 2006-10-27 Фармация Италия С.П.А. Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them
SE0104140D0 (en) 2001-12-07 2001-12-07 Astrazeneca Ab Novel Compounds
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
AU2002361846A1 (en) * 2001-12-21 2003-07-15 Bayer Pharmaceuticals Corporation Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
CA2471565C (en) * 2002-01-10 2009-10-27 Patricia Ann Day-Lollini Use of a gsk-3beta inhibitor in the manufacture of a medicament for increasing bone formation
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
SG159380A1 (en) * 2002-02-06 2010-03-30 Vertex Pharma Heteroaryl compounds useful as inhibitors of gsk-3
EP1485100B1 (en) 2002-03-15 2010-05-05 Vertex Pharmaceuticals Incorporated Azinylaminoazoles as inhibitors of protein kinases
ATE433973T1 (en) * 2002-03-15 2009-07-15 Vertex Pharma AZOLYLAMINOAZINES AS INHIBITORS OF PROTEIN KINASES
US20040009981A1 (en) 2002-03-15 2004-01-15 David Bebbington Compositions useful as inhibitors of protein kinases
WO2003086394A1 (en) 2002-04-08 2003-10-23 Merck & Co., Inc. Inhibitors of akt activity
US7524852B2 (en) 2002-06-07 2009-04-28 Kyowa Hakko Kogyo Co., Ltd. Bicyclic pyrimidine derivatives
MY141867A (en) 2002-06-20 2010-07-16 Vertex Pharma Substituted pyrimidines useful as protein kinase inhibitors
AU2003261204A1 (en) * 2002-07-23 2004-02-09 Smithkline Beecham Corporation Pyrazolopyrimidines as kinase inhibitors
ES2337782T3 (en) 2002-07-29 2010-04-29 Rigel Pharmaceuticals, Inc. METHODS TO TREAT OR PREVENT AUTOIMMUNITY DISEASES WITH 2,4-PYRIMIDINDIAMINE COMPOUNDS.
CN101037438A (en) * 2002-08-02 2007-09-19 沃泰克斯药物股份有限公司 Compositions useful as inhibitors of GSK-3
EP1739087A1 (en) * 2002-08-02 2007-01-03 Vertex Pharmaceuticals Incorporated Pyrazole compositions useful as inhibitors of gsk-3
JP4648703B2 (en) 2002-09-05 2011-03-09 アベンティス・ファーマ・ソシエテ・アノニム Novel aminoindazole derivatives as pharmaceuticals and pharmaceutical compositions containing them
FR2844267B1 (en) * 2002-09-05 2008-02-15 Aventis Pharma Sa NOVEL DERIVATIVES OF AMINOINDAZOLES AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
WO2004030672A1 (en) * 2002-10-02 2004-04-15 Merck Patent Gmbh Use of 4 amino-quinazolines as anti cancer agents
ES2440217T3 (en) * 2002-10-04 2014-01-28 Prana Biotechnology Limited Neurologically active compounds
KR100490893B1 (en) * 2002-10-11 2005-05-23 (주) 비엔씨바이오팜 2-methoxy-1,3,5-triazine derivatives, method for preparing thereof and antiviral pharmaceutical composition comprising the same
GB0226583D0 (en) * 2002-11-14 2002-12-18 Cyclacel Ltd Compounds
FR2847253B1 (en) * 2002-11-19 2007-05-18 Aventis Pharma Sa NOVEL DERIVATIVES OF PYRIDAZINONES AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
US7462613B2 (en) 2002-11-19 2008-12-09 Sanofi-Aventis Deutschland Gmbh Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them
US7309701B2 (en) 2002-11-19 2007-12-18 Sanofi-Aventis Deutschland Gmbh Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them
PL377821A1 (en) * 2002-11-21 2006-02-20 Chiron Corporation 2,4,6-trisubstituted pyrimidines as phosphotidylinositol (pi) 3-kinase inhibitors and their use in the treatment of cancer
US7601718B2 (en) * 2003-02-06 2009-10-13 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
US7157455B2 (en) * 2003-02-10 2007-01-02 Hoffmann-La Roche Inc. 4-Aminopyrimidine-5-one derivatives
EP1644338A1 (en) * 2003-04-01 2006-04-12 Aponetics AG 2, 4, 6-trisubstituted pyrimidine derivatives useful for the treatment of neoplastic and autoimmune diseases
WO2004105764A1 (en) * 2003-06-02 2004-12-09 Astrazeneca Ab (3- ((quinazolin-4-yl) amino )-1h-pyrazol-1-yl) acetamide derivatives and related compounds as aurora kinase inhibitors for the treatment of proliferative diseases such as cancer
EP1633740B1 (en) * 2003-06-19 2011-11-09 GlaxoSmithKline LLC 5-(acylamino)indazole derivatives as kinase inhibitors
US8309562B2 (en) 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
TWI372050B (en) * 2003-07-03 2012-09-11 Astex Therapeutics Ltd (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles
JP5129957B2 (en) * 2003-07-03 2013-01-30 ミリアド ジェネティクス, インコーポレイテッド 4-Arylamino-quinazolines as caspase activators and inducers of apoptosis
GB0315966D0 (en) * 2003-07-08 2003-08-13 Cyclacel Ltd Compounds
PL2256106T3 (en) 2003-07-22 2015-08-31 Astex Therapeutics Ltd 3,4-disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3) modulators
JP2007500179A (en) * 2003-07-30 2007-01-11 サイクラセル・リミテッド 2-Aminophenyl-4-phenylpyrimidine as a kinase inhibitor
ES2421139T3 (en) 2003-07-30 2013-08-29 Rigel Pharmaceuticals, Inc. 2,4-Pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases
US20050221357A1 (en) * 2003-09-19 2005-10-06 Mark Shannon Normalization of gene expression data
US7417726B2 (en) * 2003-09-19 2008-08-26 Applied Biosystems Inc. Normalization of data using controls
US20060024690A1 (en) * 2003-09-19 2006-02-02 Kao H P Normalization of data using controls
WO2005030131A2 (en) * 2003-09-23 2005-04-07 Replidyne, Inc Bis-quinazoline compounds for the treatment of bacterial infections
DE602004022187D1 (en) 2003-10-17 2009-09-03 Astrazeneca Ab 4- (PYRAZOL-3-YLAMINO) PYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER
WO2005056547A2 (en) * 2003-12-04 2005-06-23 Vertex Pharmaceuticals Incorporated Quinoxalines useful as inhibitors of protein kinases
WO2005056552A1 (en) * 2003-12-09 2005-06-23 Vertex Pharmaceuticals Incorporated Naphthyridine derivatives and their use as modulators of muscarinic receptors
EP1694686A1 (en) 2003-12-19 2006-08-30 Takeda San Diego, Inc. Kinase inhibitors
TW200530235A (en) 2003-12-24 2005-09-16 Renovis Inc Bicycloheteroarylamine compounds as ion channel ligands and uses thereof
WO2005077938A1 (en) * 2004-02-11 2005-08-25 Amgen Inc. Vanilloid receptor ligands and their use in treatments
US20080050314A1 (en) * 2004-02-26 2008-02-28 Bayer Healthcare Ag Diagnostics and Therapeutics for Diseases Associated With Glycogen Synthase Kinase 3 Beta (Gsk3b)
EP1726580A4 (en) * 2004-03-15 2008-02-13 Takeda Pharmaceutical Aminophenylpropanoic acid derivative
JP4790703B2 (en) * 2004-04-07 2011-10-12 武田薬品工業株式会社 Cyclic compounds
US20090227648A1 (en) * 2004-04-21 2009-09-10 Astrazeneca Ab Pyrazole derivatives useful for the treatment of cancer
US20050250829A1 (en) * 2004-04-23 2005-11-10 Takeda San Diego, Inc. Kinase inhibitors
JP5097539B2 (en) * 2004-05-07 2012-12-12 アムジエン・インコーポレーテツド Protein kinase modulators and methods of use
US7793137B2 (en) 2004-10-07 2010-09-07 Cisco Technology, Inc. Redundant power and data in a wired data telecommunincations network
AU2012200416B2 (en) * 2004-05-14 2014-07-31 Millennium Pharmaceuticals, Inc. "Compounds and methods for inhibiting mitotic progression by inhibition of Aurora kinase"
ATE381566T1 (en) * 2004-05-14 2008-01-15 Millennium Pharm Inc COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION BY INHIBITING AURORAKINASE
KR20070012555A (en) * 2004-05-14 2007-01-25 버텍스 파마슈티칼스 인코포레이티드 Prodrugs of pyrrolylpyrimidine erk protein kinase inhibitors
PL1905773T3 (en) * 2004-05-14 2012-12-31 Millennium Pharm Inc Compounds and methods for inhibiting mitotic progression by inhibition of aurora kinase
US20050255485A1 (en) * 2004-05-14 2005-11-17 Livak Kenneth J Detection of gene duplications
JP2007538102A (en) * 2004-05-20 2007-12-27 バイエル・フアーマシユーチカルズ・コーポレーシヨン 5-anilino-4-heteroarylpyrazole derivatives useful for the treatment of diabetes
CN1973247A (en) * 2004-05-27 2007-05-30 纳幕尔杜邦公司 Developer for a photopolymer protective layer
CA2571178A1 (en) * 2004-07-01 2006-01-19 Synta Pharmaceuticals Corp. 2-substituted heteroaryl compounds
EP1768964A1 (en) * 2004-07-06 2007-04-04 Angion Biomedica Corporation Quinazoline modulators of hepatocyte growth factor / c-met activity for the treatment of cancer
EP1778669A2 (en) * 2004-08-18 2007-05-02 Takeda San Diego, Inc. Kinase inhibitors
US7285569B2 (en) 2004-09-24 2007-10-23 Hoff Hoffmann-La Roche Inc. Tricycles, their manufacture and use as pharmaceutical agents
AR050948A1 (en) 2004-09-24 2006-12-06 Hoffmann La Roche DERIVATIVES OF FTALAZINONA; ITS OBTAINING AND ITS USE IN THE MANUFACTURE OF MEDICINES FOR THE TREATMENT OF CANCER.
EP1797048B1 (en) * 2004-09-30 2011-08-17 Tibotec Pharmaceuticals Hiv inhibiting 5-carbo- or heterocyclic substituted pyrimidines
KR20070057899A (en) * 2004-09-30 2007-06-07 티보텍 파마슈티칼즈 리미티드 Hiv inhibiting 5-heterocyclyl pyrimidines
ATE542802T1 (en) * 2004-09-30 2012-02-15 Tibotec Pharm Ltd HIV-INHIBITING 5-SUBSTITUTED PYRIMIDINES
US7713973B2 (en) 2004-10-15 2010-05-11 Takeda Pharmaceutical Company Limited Kinase inhibitors
JP4973190B2 (en) * 2004-10-29 2012-07-11 Msd株式会社 Novel aminopyridine derivatives having selective inhibition of Aurora A
US7491720B2 (en) * 2004-10-29 2009-02-17 Banyu Pharmaceutical Co., Ltd. Aminopyridine derivatives having Aurora A selective inhibitory action
JP2008519034A (en) 2004-11-03 2008-06-05 バーテックス ファーマシューティカルズ インコーポレイテッド Pyrimidine derivatives as ion channel modulators and methods of use
CN101084214A (en) * 2004-11-17 2007-12-05 迈卡纳治疗股份有限公司 Kinase inhibitors
JP5095409B2 (en) 2004-11-24 2012-12-12 ライジェル ファーマシューティカルズ, インコーポレイテッド Spiro 2,4-pyrimidinediamine compounds and uses thereof
US20060128710A1 (en) * 2004-12-09 2006-06-15 Chih-Hung Lee Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof
WO2006067614A2 (en) * 2004-12-23 2006-06-29 Pfizer Products Inc. Heteroaromatic derivatives useful as anticancer agents
WO2006074057A2 (en) 2004-12-30 2006-07-13 Exelixis, Inc. Pyrimidine derivatives as kinase modulators and method of use
RU2416610C2 (en) 2004-12-30 2011-04-20 Астекс Терапьютикс Лимитед Pharmaceutical compounds
US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
CA2592900A1 (en) 2005-01-03 2006-07-13 Myriad Genetics Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
MX2007007189A (en) 2005-01-19 2010-09-28 Rigel Pharmaceuticals Inc Prodrugs of 2,4-pyrimidinediamine compounds and their uses.
US8404718B2 (en) 2005-01-21 2013-03-26 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors
AR054425A1 (en) 2005-01-21 2007-06-27 Astex Therapeutics Ltd PIPERIDIN ADDITION SALTS 4-IL-ACID AMID 4- (2,6-DICLORO-BENZOILAMINO) 1H-PIRAZOL-3-CARBOXILICO.
CA2595514C (en) * 2005-01-26 2012-06-12 Schering Corporation Kinase inhibitors
ME02645B (en) 2005-02-04 2012-04-30 Astrazeneca Ab Pyrazolylaminopyridine derivatives useful as kinase inhibitors
PL1853588T3 (en) * 2005-02-16 2008-11-28 Astrazeneca Ab Chemical compounds
DE602006015431D1 (en) * 2005-02-16 2010-08-26 Astrazeneca Ab CHEMICAL COMPOUNDS
CN101500574A (en) * 2005-03-15 2009-08-05 Irm责任有限公司 Compounds and compositions as protein kinase inhbitors
EP1863797A1 (en) * 2005-03-23 2007-12-12 AstraZeneca AB 2-AZETIDINYL-4-(lH-PYRAZOL-3-YLAMINO)PYRIMIDINES AS INHIBITORS OF INSULIN-LIKE GROWTH FACTOR-I RECEPTOR ACTIVITY
US7297700B2 (en) * 2005-03-24 2007-11-20 Renovis, Inc. Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
KR20070116994A (en) * 2005-04-05 2007-12-11 아스트라제네카 아베 Pyrimidine derivatives for use as anticancer agents
GB0507347D0 (en) * 2005-04-12 2005-05-18 Astrazeneca Ab Chemical compounds
CA2603204A1 (en) 2005-04-14 2006-10-19 F. Hoffmann-La Roche Ag Aminopyrazole derivatives, their manufacture and use as pharmaceutical agents
CN101208093A (en) * 2005-04-27 2008-06-25 阿斯利康(瑞典)有限公司 Use of pyrazolyl-pyrimidine derivatives in the treatment of pain
AU2006241825A1 (en) * 2005-04-28 2006-11-09 Mitsubishi Tanabe Pharma Corporation Cyanopyridine derivative and use thereof as medicine
US20080207594A1 (en) 2005-05-04 2008-08-28 Davelogen Aktiengesellschaft Use of Gsk-3 Inhibitors for Preventing and Treating Pancreatic Autoimmune Disorders
JP5198256B2 (en) 2005-05-04 2013-05-15 エボテク エージー Fused heterocyclic compounds, and compositions and uses thereof
EP1888561A1 (en) * 2005-05-05 2008-02-20 AstraZeneca AB Pyrazolyl-amino- substituted pyrimidines and their use in the treatment of cancer
NZ564317A (en) * 2005-05-16 2011-01-28 Astrazeneca Ab Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors
KR101312225B1 (en) 2005-06-08 2013-09-26 리겔 파마슈티칼스, 인크. Compositions and methods for inhibition of the jak pathway
US20070203161A1 (en) 2006-02-24 2007-08-30 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
EP1890703B1 (en) 2005-06-14 2016-05-11 Taigen Biotechnology Pyrimidine compounds as chemokine receptors inhibitors
US8193206B2 (en) 2005-06-14 2012-06-05 Taigen Biotechnology Co., Ltd. Pyrimidine compounds
EP1746096A1 (en) 2005-07-15 2007-01-24 4Sc Ag 2-Arylbenzothiazole analogues and uses thereof in the treatment of cancer
AU2006279376B2 (en) * 2005-08-18 2011-04-14 Vertex Pharmaceuticals Incoporated Pyrazine kinase inhibitors
WO2007023382A2 (en) * 2005-08-25 2007-03-01 Pfizer Inc. Pyrimidine amino pyrazole compounds, potent kinase inhibitors
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
CA2622352C (en) * 2005-09-30 2014-05-27 Miikana Therapeutics, Inc. Substituted pyrazole compounds
CN101316587B (en) * 2005-09-30 2013-04-03 迈卡纳治疗股份有限公司 Substituted pyrazole compounds
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
US7985756B2 (en) 2005-10-21 2011-07-26 Braincells Inc. Modulation of neurogenesis by PDE inhibition
DK1945631T3 (en) * 2005-10-28 2012-10-22 Astrazeneca Ab 4- (3-AMINOPYRAZOLE) PYRIMIDINE DERIVATIVES USED AS TYROSINKINASE INHIBITORS FOR CANCER TREATMENT
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
ES2372540T3 (en) * 2005-11-01 2012-01-23 Array Biopharma, Inc. GLUCOCINASE ACTIVATORS.
NZ594385A (en) * 2005-11-03 2013-02-22 Vertex Pharma Aminopyrimidines useful as kinase inhibitors
EP1951716B1 (en) * 2005-11-16 2011-05-04 Vertex Pharmaceuticals, Inc. Aminopyrimidines useful as kinase inhibitors
US8546404B2 (en) * 2005-12-13 2013-10-01 Merck Sharp & Dohme Compounds that are ERK inhibitors
US7572809B2 (en) * 2005-12-19 2009-08-11 Hoffmann-La Roche Inc. Isoquinoline aminopyrazole derivatives
WO2007077435A1 (en) 2005-12-30 2007-07-12 Astex Therapeutics Limited Pharmaceutical compounds
WO2007081978A2 (en) * 2006-01-11 2007-07-19 Angion Biomedica Corporation Modulators of hepatocyte growth factor / c-met activity
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي PI-3 Kinase inhibitors and methods of their use
JP2009528280A (en) 2006-02-16 2009-08-06 シェーリング コーポレイション Pyrrolidine derivatives as ERK inhibitors
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
PE20080145A1 (en) 2006-03-21 2008-02-11 Janssen Pharmaceutica Nv TETRAHYDRO-PYRIMIDOAZEPINE AS MODULATORS OF TRPV1
AU2007233737B2 (en) 2006-03-30 2012-11-29 Janssen Sciences Ireland Uc HIV inhibiting 5-amido substituted pyrimidines
JP5255559B2 (en) * 2006-03-31 2013-08-07 アボット・ラボラトリーズ Indazole compound
KR20090023561A (en) 2006-04-07 2009-03-05 노파르티스 아게 Combination comprising a) a pyrimidylaminobenzamide compound, and b) a thr315ile kinase inhibitor
JP5290147B2 (en) 2006-04-14 2013-09-18 プラナ バイオテクノロジー リミティッド Method for treating age-related macular degeneration (AMD)
JP5161072B2 (en) * 2006-04-27 2013-03-13 Msd株式会社 Novel aminopyridine derivatives having selective inhibition of Aurora A
JP2009536669A (en) 2006-05-09 2009-10-15 ブレインセルス,インコーポレイティド Neurogenesis by angiotensin regulation
MX2008014320A (en) 2006-05-09 2009-03-25 Braincells Inc 5 ht receptor mediated neurogenesis.
GEP20115359B (en) 2006-06-27 2011-12-26 Takeda Pharmaceutical Fused cyclic compounds
JP5523829B2 (en) 2006-06-29 2014-06-18 アステックス、セラピューティックス、リミテッド Compound drug
EP2043635A2 (en) * 2006-06-29 2009-04-08 Astex Therapeutics Limited Pharmaceutical combinations
EP2044063A1 (en) * 2006-06-30 2009-04-08 Astra Zeneca AB Pyrimidine derivatives useful in the treatment of cancer
US20090209537A1 (en) * 2006-06-30 2009-08-20 Kyowa Hakko Kirin Co., Ltd. Aurora inhibitors
EP2043651A2 (en) 2006-07-05 2009-04-08 Exelixis, Inc. Methods of using igf1r and abl kinase modulators
KR20090047458A (en) 2006-08-08 2009-05-12 사노피-아벤티스 Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use
US7718648B2 (en) * 2006-08-09 2010-05-18 Millennium Pharmaceuticals, Inc. Pyridobenzazepine compounds and methods for inhibiting mitotic progression
US7744164B2 (en) * 2006-08-11 2010-06-29 Schluimberger Technology Corporation Shield of a degradation assembly
JP2008081492A (en) * 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd New aminopyridine derivative having aurora a selective inhibitory action
AU2007292848A1 (en) * 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EP2223925A1 (en) * 2006-10-09 2010-09-01 Takeda Pharmaceutical Company Limited Kinase inhibitors
EA200970361A1 (en) 2006-10-09 2010-02-26 Такеда Фармасьютикал Компани Лимитед KINASE INHIBITORS
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
JP5528807B2 (en) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド Compound drug
WO2008053812A1 (en) * 2006-10-27 2008-05-08 Mitsubishi Tanabe Pharma Corporation Cyanopyridine derivative and medicinal use thereof
MX2009004807A (en) * 2006-11-02 2009-06-15 Vertex Pharma Aminopyridines and aminopyrimidines useful as inhibitors of protein kinases.
CL2007003244A1 (en) 2006-11-16 2008-04-04 Millennium Pharm Inc COMPOUNDS DERIVED FROM PIRIMIDO [5,4-D] [2] BENZAZEPINA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUND; AND USE OF THE COMPOUND FOR THE TREATMENT OF CANCER.
DE602007007985D1 (en) * 2006-12-19 2010-09-02 Vertex Pharma AS INHIBITORS OF PROTEIN KINASES SUITABLE AMINO-PRIMIDINES
CN101573343B (en) * 2006-12-29 2016-02-24 爱尔兰詹森科学公司 The pyrimidine of the 6-replacement of HIV inhibiting
EA020749B1 (en) * 2006-12-29 2015-01-30 Тиботек Фармасьютикалз Лтд. Hiv inhibiting 5,6-substituted pyrimidines
KR20090108124A (en) 2007-02-06 2009-10-14 노파르티스 아게 Pi 3-kinase inhibitors and methods of their use
US20100104567A1 (en) 2007-03-05 2010-04-29 Kyowa Hakko Kirin Co., Ltd. Pharmaceutical composition
AU2008226466B2 (en) * 2007-03-09 2013-06-13 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as inhibitors of protein kinases
JP5520057B2 (en) * 2007-03-09 2014-06-11 バーテックス ファーマシューティカルズ インコーポレイテッド Aminopyrimidines useful as inhibitors of protein kinases
EP2134709A1 (en) 2007-03-09 2009-12-23 Vertex Pharmaceuticals, Inc. Aminopyridines useful as inhibitors of protein kinases
AU2008228963A1 (en) * 2007-03-20 2008-09-25 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as kinase inhibitors
WO2008117050A1 (en) * 2007-03-27 2008-10-02 Astrazeneca Ab Pyrazolyl-amino-substituted pyrazines and their use for the treatment of cancer
CN101679386A (en) * 2007-04-13 2010-03-24 沃泰克斯药物股份有限公司 Aminopyrimidines useful as kinase inhibitors
GEP20125581B (en) 2007-04-18 2012-07-25 Pfizer Prod Inc Sulfonyl amide derivatives for treatment of abnormal cell growth
WO2008129255A1 (en) * 2007-04-18 2008-10-30 Astrazeneca Ab 5-aminopyrazol-3-yl-3h-imidazo [4,5-b] pyridine derivatives and their use for the treatment of cancer
AU2008247594A1 (en) * 2007-05-02 2008-11-13 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as kinase inhibitors
JP5572087B2 (en) * 2007-05-02 2014-08-13 バーテックス ファーマシューティカルズ インコーポレイテッド Aminopyrimidines useful as kinase inhibitors
EP2152694A2 (en) 2007-05-02 2010-02-17 Vertex Pharmaceuticals Incorporated Thiazoles and pyrazoles useful as kinase inhibitors
ES2369596T3 (en) * 2007-05-04 2011-12-02 Astrazeneca Ab DERIVATIVES OF AMINO-TIAZOLIL-PYRIMIDINE AND ITS USE FOR THE TREATMENT OF CANCER.
UA99459C2 (en) 2007-05-04 2012-08-27 Астразенека Аб 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer
AU2008257044A1 (en) * 2007-05-24 2008-12-04 Vertex Pharmaceuticals Incorporated Thiazoles and pyrazoles useful as kinase inhibitors
KR101294731B1 (en) * 2007-06-04 2013-08-16 삼성디스플레이 주식회사 Array substrate, display panel having the array substrate and method of manufacturing the array substrate
JP2010529193A (en) * 2007-06-11 2010-08-26 ミイカナ セラピューティクス インコーポレイテッド Substituted pyrazole compounds
US20090274698A1 (en) * 2007-07-06 2009-11-05 Shripad Bhagwat Combination anti-cancer therapy
WO2009007753A2 (en) * 2007-07-11 2009-01-15 Astrazeneca Ab 4- (3-aminopyrazole) -pyrimidine derivativee and their use as tyrosine kinase inhibitors for the treatment of cancer
EP2175933B1 (en) * 2007-07-25 2012-08-22 Bristol-Myers Squibb Company Triazine kinase inhibitors
WO2009013545A2 (en) * 2007-07-26 2009-01-29 Astrazeneca Ab Chemical compounds
TW200906818A (en) * 2007-07-31 2009-02-16 Astrazeneca Ab Chemical compounds
EP2176261B1 (en) * 2007-07-31 2012-12-19 Vertex Pharmaceuticals Incorporated Process for preparing 5-fluoro-1h-pyrazolo [3, 4-b] pyridin-3-amine and derivatives thereof
EP2025674A1 (en) 2007-08-15 2009-02-18 sanofi-aventis Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs
WO2009027736A2 (en) * 2007-08-27 2009-03-05 Astrazeneca Ab 2,4 diaminopyrimid'lnes for the treatment of myeloproliferative disorders and cancer
CN101868459B (en) 2007-09-21 2013-12-18 阿雷生物药品公司 Pyridin-2 -yl-amino-1, 2, 4 -thiadiazole derivatives as glucokinase activators for treatment of diabetes mellitus
MX2010003942A (en) 2007-10-11 2010-04-30 Glaxosmithkline Llc Novel seh inhibitors and their use.
WO2009078999A1 (en) 2007-12-17 2009-06-25 Janssen Pharmaceutica N.V. Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of trpv1
US20090270418A1 (en) * 2008-01-09 2009-10-29 Marianne Sloss Pyrazole pyrazine amine compounds as kinase inhibitors, compositions thereof and methods of treatment therewith
EP2242745A1 (en) * 2008-02-07 2010-10-27 Sanofi-Aventis Novel phenyl-substituted imidazolidines, method for the production thereof, medicaments containing said compounds and use thereof
CA2714479A1 (en) * 2008-02-21 2009-08-27 Schering Corporation Compounds that are erk inhibitors
AU2009216062B2 (en) * 2008-02-22 2013-02-07 Msd K.K. Novel aminopyridine derivatives having Aurora A selective inhibitory action
EP2268635B1 (en) 2008-04-21 2015-06-10 Taigen Biotechnology Co., Ltd. Heterocyclic compounds
US8844033B2 (en) 2008-05-27 2014-09-23 The Trustees Of Columbia University In The City Of New York Systems, methods, and media for detecting network anomalies using a trained probabilistic model
EP2288602A1 (en) * 2008-06-11 2011-03-02 AstraZeneca AB Tricyclic 2,4-diamin0-l,3,5-triazine derivatives useful for the treatment of cancer and myeloproliferative disorders
US8470841B2 (en) 2008-07-09 2013-06-25 Sanofi Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
AU2009276339B2 (en) * 2008-07-31 2012-06-07 Genentech, Inc. Pyrimidine compounds, compositions and methods of use
JP2012501971A (en) * 2008-09-03 2012-01-26 バーテックス ファーマシューティカルズ インコーポレイテッド Co-crystals and pharmaceutical formulations containing co-crystals
NZ621143A (en) * 2008-09-05 2016-08-26 Celgene Avilomics Res Inc Algorithm for designing irreversible inhibitors
CA2737388C (en) * 2008-09-15 2017-07-11 Peter Walter Methods and compositions for modulating ire1, src, and abl activity
KR20110071098A (en) * 2008-09-30 2011-06-28 아스트라제네카 아베 Heterocyclic jak kinase inhibitors
US8759362B2 (en) * 2008-10-24 2014-06-24 Purdue Pharma L.P. Bicycloheteroaryl compounds and their use as TRPV1 ligands
WO2010056758A1 (en) * 2008-11-12 2010-05-20 Yangbo Feng Quinazoline derivatives as kinase inhibitors
WO2010056847A2 (en) 2008-11-13 2010-05-20 Taigen Biotechnology Co., Ltd. Lyophilization formulation
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
PA8851101A1 (en) 2008-12-16 2010-07-27 Lilly Co Eli AMINO PIRAZOL COMPOUND
JP5490137B2 (en) * 2008-12-19 2014-05-14 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ Bicyclic pyrazoles as protein kinase inhibitors
CN102264368B (en) 2008-12-22 2014-09-10 米伦纽姆医药公司 Combination of aurora kinase inhibitors and anti-CD20 antibodies
WO2010072155A1 (en) * 2008-12-26 2010-07-01 复旦大学 Pyrimidine derivative, preparation method and use thereof
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
SI2401267T1 (en) 2009-02-27 2014-05-30 Ambit Biosciences Corporation Jak kinase modulating quinazoline derivatives and their use in methods
CA2660962A1 (en) 2009-03-31 2010-09-30 Astellas Pharma Inc. Novel pharmaceutical composition for treatment of schizophrenia
US8399663B2 (en) 2009-04-03 2013-03-19 Astellas Pharma Inc. Salt of 1,3,5-triazine-2,4,6-triamine derivative
JO3635B1 (en) 2009-05-18 2020-08-27 Millennium Pharm Inc Solid pharmaceutical compositions and processes for their production
JP2012529511A (en) * 2009-06-08 2012-11-22 アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー Triazine derivatives and their therapeutic applications
US20120172361A1 (en) * 2009-06-08 2012-07-05 California Capital Equity, Llc Triazine derivatives and their therapeutical applications
KR20120016676A (en) * 2009-06-09 2012-02-24 아브락시스 바이오사이언스, 엘엘씨 Ureidophenyl substituted triazine derivatives and their therapeutical applications
JP5785940B2 (en) * 2009-06-09 2015-09-30 アブラクシス バイオサイエンス, エルエルシー Triazine derivatives and their therapeutic applications
EP2440053A4 (en) * 2009-06-09 2012-10-31 California Capital Equity Llc Benzyl substituted triazine derivatives and their therapeutical applications
WO2010144423A1 (en) * 2009-06-09 2010-12-16 Abraxis Bioscience, Llc Styryl-triazine derivatives and their therapeutical applications
CA2763730A1 (en) * 2009-06-18 2010-12-23 Cellzome Limited Heterocyclylaminopyrimidines as kinase inhibitors
US8637525B2 (en) 2009-07-31 2014-01-28 Bristol-Myers Squibb Company Compounds for the reduction of beta-amyloid production
TWI468402B (en) * 2009-07-31 2015-01-11 必治妥美雅史谷比公司 Compounds for the reduction of β-amyloid production
RU2012111354A (en) 2009-08-26 2013-10-10 Санофи NEW CRYSTALLINE HYDRATES OF FLUORGYCLOSIDES CONTAINING THEIR PHARMACEUTICAL DRUGS AND THEIR USE
NZ598705A (en) 2009-09-16 2014-06-27 Celgene Avilomics Res Inc Protein kinase conjugates and inhibitors
EP3639783A1 (en) * 2009-11-13 2020-04-22 Intuitive Surgical Operations, Inc. End effector with redundant closing mechanisms
AU2010343102B2 (en) 2009-12-29 2016-03-24 Dana-Farber Cancer Institute, Inc. Type II Raf kinase inhibitors
SG181965A1 (en) 2009-12-30 2012-08-30 Avila Therapeutics Inc Ligand-directed covalent modification of protein
SA111320200B1 (en) * 2010-02-17 2014-02-16 ديبيوفارم اس ايه Bicyclic Compounds and their Uses as Dual C-SRC / JAK Inhibitors
JP2013520424A (en) 2010-02-19 2013-06-06 ミレニアム ファーマシューティカルズ, インコーポレイテッド Sodium 4-{[9-chloro-7- (2-fluoro-6-methoxyphenyl) -5H-pyrimido [5,4-d] [2] benzoazepin-2-yl] amino} -2-methoxybenzoate Crystal form
WO2011107494A1 (en) 2010-03-03 2011-09-09 Sanofi Novel aromatic glycoside derivatives, medicaments containing said compounds, and the use thereof
WO2011146354A1 (en) * 2010-05-20 2011-11-24 Merck Sharp & Dohme Corp. Novel prolylcarboxypeptidase inhibitors
CA2798578C (en) 2010-05-21 2015-12-29 Chemilia Ab Novel pyrimidine derivatives
CN103038230B (en) 2010-06-04 2016-05-25 霍夫曼-拉罗奇有限公司 As the aminopyridine derivative of LRRK2 conditioning agent
EP2582709B1 (en) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
US9181198B2 (en) 2010-07-29 2015-11-10 Oryzon Genomics S.A. Arylcyclopropylamine based demethylase inhibitors of LSD1 and their medical use
WO2012030944A2 (en) * 2010-09-01 2012-03-08 Ambit Biosciences Corporation Quinoline and isoquinoline compounds and methods of use thereof
US20120053176A1 (en) * 2010-09-01 2012-03-01 Ambit Biosciences Corp. Adenosine a3 receptor modulating compounds and methods of use thereof
EP2611793A1 (en) * 2010-09-01 2013-07-10 Ambit Biosciences Corporation 2-cycloquinazoline derivatives and methods of use thereof
WO2012030917A1 (en) * 2010-09-01 2012-03-08 Ambit Biosciences Corporation An optically active pyrazolylaminoquinazoline, and pharmaceutical compositions and methods of use thereof
EP2611794A1 (en) * 2010-09-01 2013-07-10 Ambit Biosciences Corporation 4-azolylaminoquinazoline derivatives and methods of use thereof
CA2810024A1 (en) 2010-09-01 2012-03-08 Ambit Biosciences Corporation Quinazoline compounds and methods of use thereof
ES2619850T3 (en) * 2010-09-01 2017-06-27 Ambit Biosciences Corporation Hydrobromide salts of a pyrazolilaminoquinazoline
WO2012059932A1 (en) 2010-11-01 2012-05-10 Aurigene Discovery Technologies Limited 2, 4 -diaminopyrimidine derivatives as protein kinase inhibitors
NO2638031T3 (en) 2010-11-10 2018-03-10
WO2012120058A1 (en) 2011-03-08 2012-09-13 Sanofi Oxathiazine derivatives which are substituted with benzyl or heteromethylene groups, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
US8809325B2 (en) 2011-03-08 2014-08-19 Sanofi Benzyl-oxathiazine derivatives substituted with adamantane and noradamantane, medicaments containing said compounds and use thereof
WO2012120054A1 (en) 2011-03-08 2012-09-13 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120050A1 (en) 2011-03-08 2012-09-13 Sanofi Novel substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
WO2012120057A1 (en) 2011-03-08 2012-09-13 Sanofi Novel substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683699B1 (en) 2011-03-08 2015-06-24 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8901114B2 (en) 2011-03-08 2014-12-02 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
WO2012120056A1 (en) 2011-03-08 2012-09-13 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
ES2587864T3 (en) 2011-03-24 2016-10-27 Noviga Research Ab Pyrimidine derivatives
US8637537B2 (en) 2011-08-25 2014-01-28 Genentech, Inc. Serine/threonine kinase inhibitors
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EA201490673A1 (en) 2011-09-22 2014-06-30 Пфайзер Инк. DERIVATIVES OF PYRROLOPYRIMIDINE AND PURIN
CU24269B1 (en) 2011-09-27 2017-08-08 Novartis Ag 3- PIRIMIDIN- 4-IL- OXAZOLIDIN- 2- INHIBITING WAVES OF THE MUTANT HDI
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
JP6106685B2 (en) 2011-11-17 2017-04-05 ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド Inhibitors of C-JUN-N-terminal kinase (JNK)
KR20140103972A (en) 2011-12-22 2014-08-27 에프. 호프만-라 로슈 아게 2,4-diamine-pyrimidine derivatives as serine/threonine kinase inhibitors
CA2864825C (en) * 2012-02-17 2021-01-26 Abbvie Inc. Diaminopyrimidines useful as inhibitors of the human respiratory syncytial virus (rsv)
UY34632A (en) 2012-02-24 2013-05-31 Novartis Ag OXAZOLIDIN- 2- ONA COMPOUNDS AND USES OF THE SAME
TWI485146B (en) * 2012-02-29 2015-05-21 Taiho Pharmaceutical Co Ltd Novel piperidine compounds or salts thereof
CN104302640A (en) 2012-03-16 2015-01-21 埃克希金医药品有限公司 3,5-diaminopyrazole kinase inhibitors
US20130303519A1 (en) 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors
DK3459942T3 (en) 2012-04-24 2021-03-08 Vertex Pharma DNA-PK inhibitors
JP6197031B2 (en) * 2012-05-24 2017-09-13 セルゾーム リミティッド Heterocyclyl pyrimidine analogs as TYK2 inhibitors
JP6280546B2 (en) 2012-06-26 2018-02-14 デル マー ファーマシューティカルズ Treating tyrosine kinase inhibitor resistant malignancies in patients with genetic polymorphisms or dysregulation or mutation of AHI1 using dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulucitol, or analogs or derivatives thereof How to
US9216991B2 (en) * 2012-07-10 2015-12-22 Ares Trading S.A. Pyrimidine pyrazolyl derivatives
BR112015005489B1 (en) * 2012-09-19 2022-07-12 Taiho Pharmaceutical Co., Ltd. PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION WITH IMPROVED DISSOLUTION AND/OR ABSORPTION
US9296733B2 (en) 2012-11-12 2016-03-29 Novartis Ag Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
CN103191120B (en) * 2012-12-31 2015-11-25 刘强 A kind of pyrimidine derivatives preparation prevent and/or treat and/or adjuvant therapy of tumors medicine in purposes
CN103059002B (en) * 2012-12-31 2015-04-22 中山大学 Pyrimidine derivative with Aurora kinase inhibitory activity and preparation method and application thereof
CN103202843B (en) * 2012-12-31 2015-04-29 刘强 Application of pyrimidine derivative in preparation of drugs capable of prevention and/or treatment and/or adjuvant therapy of cancers
CN103910716A (en) * 2013-01-07 2014-07-09 华东理工大学 2,4-disubstituted-cycloalkyl[d]pyrimidine compound and its use
EP3985003B1 (en) 2013-03-12 2023-08-09 Vertex Pharmaceuticals Incorporated Dna-pk inhibitors
EA028033B1 (en) 2013-03-14 2017-09-29 Новартис Аг 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
EP3842424A1 (en) 2013-03-15 2021-06-30 The Trustees of Columbia University in the City of New York Map kinase modulators and uses thereof in the tretament of tauopathies
JP6360881B2 (en) 2013-03-22 2018-07-18 ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. Combination of catalytic MTORC1 / 2 inhibitor and selective inhibitor of Aurora A kinase
WO2015003355A2 (en) * 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
CN105764502A (en) 2013-07-26 2016-07-13 现代化制药公司 Combinatorial methods to improve the therapeutic benefit of bisantrene and analogs and derivatives thereof
WO2015028848A1 (en) * 2013-09-02 2015-03-05 Piramal Enterprises Limited Bicyclic heterocyclic compounds as multi-kinase inhibitors
NZ631142A (en) 2013-09-18 2016-03-31 Axikin Pharmaceuticals Inc Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors
SI3424920T1 (en) 2013-10-17 2020-08-31 Vertex Pharmaceuticals Incorporated Co-crystals of (s)-n-methyl-8-(1-((2'-methyl-(4,5'-bipyrimidin)-6-yl)amino)propan-2-yl)quinoline-4-carboxamide and deuterated derivatives thereof as dna-pk inhibitors
AU2014337044A1 (en) 2013-10-18 2016-05-05 Dana-Farber Cancer Institute, Inc. Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7)
US20160264551A1 (en) 2013-10-18 2016-09-15 Syros Pharmaceuticals, Inc. Heteroaromatic compounds useful for the treatment of prolferative diseases
HUE050761T2 (en) 2014-01-01 2021-01-28 Medivation Tech Llc Compounds and methods of use
PT3116475T (en) 2014-03-13 2020-12-15 Neuroderm Ltd Dopa decarboxylase inhibitor compositions
US10258585B2 (en) 2014-03-13 2019-04-16 Neuroderm, Ltd. DOPA decarboxylase inhibitor compositions
JP6538148B2 (en) 2014-03-28 2019-07-03 キャリター・サイエンシーズ・リミテッド・ライアビリティ・カンパニーCalitor Sciences, Llc Substituted heteroaryl compounds and methods of use
CA2944240A1 (en) 2014-04-04 2015-10-08 Iomet Pharma Ltd Indole derivatives as ido/tdo inhibitors
WO2015155738A2 (en) 2014-04-09 2015-10-15 Christopher Rudd Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity
CN105367555B (en) * 2014-08-07 2019-06-25 广东东阳光药业有限公司 Substituted heteroaryl compound and combinations thereof and purposes
JP6450010B2 (en) 2014-12-23 2019-01-09 アクシキン ファーマシューティカルズ インコーポレーテッド 3,5-diaminopyrazole kinase inhibitor
CA2972239A1 (en) 2014-12-23 2016-06-30 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
US10227343B2 (en) * 2015-01-30 2019-03-12 Vanderbilt University Isoquiniline and napthalene-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
CA2978518C (en) 2015-03-27 2023-11-21 Nathanael S. Gray Inhibitors of cyclin-dependent kinases
CA2982890C (en) 2015-04-17 2023-08-22 Ludwig Institute For Cancer Research Ltd Plk4 inhibitors
SG10201910742VA (en) 2015-05-28 2020-01-30 Theravance Biopharma R&D Ip Llc Naphthyridine compounds as jak kinase inhibitors
JP2018135268A (en) * 2015-06-05 2018-08-30 大日本住友製薬株式会社 Novel heteroaryl amino-3-pyrazole derivative and pharmacologically acceptable salt thereof
EP3324976A4 (en) 2015-07-21 2019-03-27 Millennium Pharmaceuticals, Inc. Administration of aurora kinase inhibitor and chemotherapeutic agents
CA2996978A1 (en) 2015-09-09 2017-03-16 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
EP3347097B1 (en) 2015-09-11 2021-02-24 Sunshine Lake Pharma Co., Ltd. Substituted aminopyrimidine derivatives as modulators of the kinases jak, flt3 and aurora
KR102488323B1 (en) * 2015-12-10 2023-01-12 피티씨 테라퓨틱스, 인크. Composition for treating or ameliorating Huntington's disease
CN105399695B (en) * 2015-12-11 2019-04-19 浙江大学 Compound in triazine class and its preparation method and application
CN105384702B (en) * 2015-12-11 2018-04-10 浙江大学 Three substitution s-triazine compounds and preparation method thereof
CN105503754B (en) * 2015-12-11 2017-11-17 浙江大学 The triazine of 2 amino, 4 benzyl, 6 morpholine 1,3,5 and its preparation and application
WO2017102091A1 (en) 2015-12-18 2017-06-22 Bayer Pharma Aktiengesellschaft Heteroarylbenzimidazole compounds
US10822311B2 (en) 2016-03-14 2020-11-03 Afferent Pharmaceuticals, Inc. Pyrimidines and variants thereof, and uses therefor
JP6902045B2 (en) 2016-03-25 2021-07-14 アファレント ファーマシューティカルズ インコーポレイテッド Pyrimidines and their variants, and their use
SG11201809342YA (en) 2016-04-28 2018-11-29 Theravance Biopharma R&D Ip Llc Pyrimidine compounds as jak kinase inhibitors
WO2017207534A1 (en) 2016-06-03 2017-12-07 Bayer Pharma Aktiengesellschaft Substituted heteroarylbenzimidazole compounds
MX2019003317A (en) 2016-09-27 2019-08-05 Vertex Pharma Method for treating cancer using a combination of dna-damaging agents and dna-pk inhibitors.
US10858319B2 (en) 2016-10-03 2020-12-08 Iomet Pharma Ltd. Indole derivatives for use in medicine
US10968227B2 (en) * 2016-11-08 2021-04-06 Vanderbilt University Isoquinoline ether compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
CN108239071B (en) * 2016-12-27 2020-12-04 沈阳药科大学 Amide and thioamide derivatives, and preparation method and application thereof
FR3064275B1 (en) 2017-03-21 2019-06-07 Arkema France METHOD FOR HEATING AND / OR AIR CONDITIONING A VEHICLE
IL270873B2 (en) 2017-05-30 2023-04-01 Basf Se “derivatives of pyridine and pyrazine compounds, composition comprising them and their use as fungicides”
SG11201911615WA (en) 2017-06-05 2020-01-30 Ptc Therapeutics Inc Compounds for treating huntington's disease
CA3067591A1 (en) 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. Methods for treating huntington's disease
CA3067592A1 (en) 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. Methods for treating huntington's disease
WO2019001572A1 (en) 2017-06-30 2019-01-03 北京泰德制药股份有限公司 Rho-associated protein kinase inhibitor, pharmaceutical composition comprising same, and preparation method and use thereof
KR102563325B1 (en) * 2017-06-30 2023-08-03 베이징 타이드 파마슈티컬 코퍼레이션 리미티드 ROH-related protein kinase inhibitors, pharmaceutical compositions containing RS-related protein kinase inhibitors, manufacturing methods and uses of pharmaceutical compositions
US10323023B2 (en) 2017-06-30 2019-06-18 Beijing Tide Pharmaceutical Co., Ltd. Rho-associated protein kinase inhibitor, pharmaceutical composition comprising the same, as well as preparation method and use thereof
US20200199136A1 (en) * 2017-08-28 2020-06-25 Acurastem Inc. Pikfyve kinase inhibitors
EP3675860B1 (en) * 2017-08-28 2023-03-08 Zhihong, Chen Substituted pyrimidines, pharmaceutical compositions and therapeutic methods thereof
MA49956B1 (en) 2017-10-27 2022-11-30 Theravance Biopharma R&D Ip Llc Pyrimidine compounds used as jak kinase inhibitors
WO2019101843A1 (en) * 2017-11-23 2019-05-31 Biomed X Gmbh Pyrimidine derivatives as tropomyosin receptor kinase a (trka) inhibitors
EP3720560A4 (en) * 2017-12-06 2022-01-05 Ludwig Institute for Cancer Research Ltd Methods of treating cancer with plk4 inhibitors
WO2019191092A1 (en) 2018-03-27 2019-10-03 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
CN112367991A (en) * 2018-06-25 2021-02-12 达纳-法伯癌症研究所股份有限公司 TAIRE family kinase inhibitors and uses thereof
EP3814360A1 (en) 2018-06-27 2021-05-05 PTC Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
MX2020014098A (en) 2018-06-27 2021-05-27 Ptc Therapeutics Inc Heterocyclic and heteroaryl compounds for treating huntington's disease.
JP7470713B2 (en) 2019-04-24 2024-04-18 セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー Ester and Carbonate Pyrimidine Compounds as JAK Kinase Inhibitors - Patent application
US11439641B2 (en) 2019-04-24 2022-09-13 Theravance Biopharma R&D Ip, Llc Pyrimidine JAK inhibitors for the treatment of skin diseases
US20220281842A1 (en) * 2019-08-01 2022-09-08 Integral Biosciences Pvt. Ltd. Heterocyclic compounds as kinase inhibitor and uses thereof
US11370803B2 (en) 2019-09-18 2022-06-28 Takeda Pharmaceutical Company Limited Heteroaryl plasma kallikrein inhibitors
CN114728962A (en) 2019-09-18 2022-07-08 武田药品工业有限公司 Plasma kallikrein inhibitors and uses thereof
CN110483493A (en) * 2019-09-19 2019-11-22 广东工业大学 A kind of diazole analog derivative and its preparation method and application
US11844754B2 (en) 2020-11-17 2023-12-19 Neuroderm, Ltd. Methods for treatment of Parkinson's disease
US11331293B1 (en) 2020-11-17 2022-05-17 Neuroderm, Ltd. Method for treatment of Parkinson's disease
US11213502B1 (en) 2020-11-17 2022-01-04 Neuroderm, Ltd. Method for treatment of parkinson's disease
TW202237119A (en) 2020-12-10 2022-10-01 美商住友製藥腫瘤公司 Alk-5 inhibitors and uses thereof
CN117355523A (en) * 2021-03-17 2024-01-05 武田药品工业株式会社 Polycyclic inhibitors of plasma kallikrein
EP4313052A1 (en) * 2021-03-26 2024-02-07 Sumitomo Pharma Oncology, Inc. Alk-5 inhibitors and uses thereof
IL308346A (en) 2021-05-11 2024-01-01 Oric Pharmaceuticals Inc Polo like kinase 4 inhibitors
WO2023278326A1 (en) 2021-06-28 2023-01-05 Blueprint Medicines Corporation Cdk2 inhibitors
KR102692529B1 (en) * 2021-07-01 2024-08-08 한국원자력의학원 Pharmaceutical Composition For Preventing or Treating Cancer Targeting MASTL-PP2A
CN116354938B (en) * 2021-12-28 2024-02-20 沈阳药科大学 Preparation method and application of quinazoline derivatives and analogues thereof
CN114276302B (en) * 2022-01-11 2023-07-25 山东百启生物医药有限公司 Method for preparing 2, 4-diaminoquinazoline derivative
WO2024003773A1 (en) 2022-07-01 2024-01-04 Pfizer Inc. 2,7-naphthyridine compounds as mastl inhibitors
CN115403568B (en) * 2022-09-21 2023-09-29 中山大学 Quinazoline Aurora A covalent inhibitor and preparation method and application thereof
CN117736198A (en) * 2022-09-21 2024-03-22 科辉智药生物科技(深圳)有限公司 Macrocyclic nitrogen crown ether compounds and their use as protein kinase inhibitors

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US18436A (en) * 1857-10-20 And saml
US3133081A (en) * 1964-05-12 J-aminoindazole derivatives
US2585906A (en) 1952-02-12 Quaternary salts of pyrimdjines
US3935183A (en) * 1970-01-26 1976-01-27 Imperial Chemical Industries Limited Indazole-azo phenyl compounds
BE754242A (en) * 1970-07-15 1971-02-01 Geigy Ag J R DIAMINO-S-TRIAZINES AND DINITRO-S-TRIAZINES
US3755332A (en) * 1971-07-01 1973-08-28 Ciba Geigy Corp Substituted 4 indazolaminoquinolines
US3998951A (en) * 1974-03-13 1976-12-21 Fmc Corporation Substituted 2-arylquinazolines as fungicides
DE2458965C3 (en) * 1974-12-13 1979-10-11 Bayer Ag, 5090 Leverkusen 3-Amino-indazole-N-carboxylic acid derivatives, process for their preparation and pharmaceuticals containing them
MA18829A1 (en) 1979-05-18 1980-12-31 Ciba Geigy Ag PYRIMIDINE DERIVATIVES, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND THEIR THERAPEUTIC USE
DOP1981004033A (en) * 1980-12-23 1990-12-29 Ciba Geigy Ag PROCEDURE TO PROTECT CROP PLANTS FROM PHYTOTOXIC ACTION OF HERBICIDES.
SE8102194L (en) * 1981-04-06 1982-10-07 Pharmacia Ab THERAPEUTIC ACTIVE ORGANIC ASSOCIATION AND PHARMACEUTICAL PREPARATION INCLUDING THIS
SE8102193L (en) * 1981-04-06 1982-10-07 Pharmacia Ab THERAPEUTIC ACTIVE ORGANIC ASSOCIATION AND ITS USE
JPS58124773A (en) 1982-01-20 1983-07-25 Mitsui Toatsu Chem Inc 5-methylthiopyrimidine derivative, its preparation and fungicide for agricultural and horticultural purposes
EP0136976A3 (en) 1983-08-23 1985-05-15 Ciba-Geigy Ag Use of phenyl pyrimidines as plant regulators
DE3725638A1 (en) 1987-08-03 1989-02-16 Bayer Ag NEW ARYLOXY (OR THIO) AMINOPYRIMIDINE
JPH0532662A (en) 1990-11-09 1993-02-09 Nissan Chem Ind Ltd Substituted pyrazole derivative and agricultural and horticultural fungicide
US5710158A (en) 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5714493A (en) * 1991-05-10 1998-02-03 Rhone-Poulenc Rorer Pharmaceuticals, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5597920A (en) 1992-04-30 1997-01-28 Neurogen Corporation Gabaa receptor subtypes and methods for screening drug compounds using imidazoquinoxalines and pyrrolopyrimidines to bind to gabaa receptor subtypes
JPH0665237A (en) * 1992-05-07 1994-03-08 Nissan Chem Ind Ltd Substituted pyrazole derivative and germicide for agriculture and horticulture
JP3588116B2 (en) 1993-10-01 2004-11-10 ノバルティス アクチェンゲゼルシャフト Pharmacologically active pyrimidineamine derivatives and process for their production
EP0788358B1 (en) 1994-11-10 2004-03-31 Millennium Pharmaceuticals, Inc. Use of pyrazole compounds for the treatment of glomerulonephritis, cancer, atherosclerosis or restenosis
IL117659A (en) * 1995-04-13 2000-12-06 Dainippon Pharmaceutical Co Substituted 2-phenyl pyrimidino amino acetamide derivative process for preparing the same and a pharmaceutical composition containing same
US5935966A (en) 1995-09-01 1999-08-10 Signal Pharmaceuticals, Inc. Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions
JPH11512390A (en) 1995-09-01 1999-10-26 シグナル ファーマシューティカルズ,インコーポレイテッド Pyrimidine carboxylate and related compounds and methods for treating inflammatory conditions
GB9523675D0 (en) 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
US6716575B2 (en) * 1995-12-18 2004-04-06 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
ID19609A (en) 1996-07-13 1998-07-23 Glaxo Group Ltd HETEROSICLIC COMPOUNDS
JPH10130150A (en) 1996-09-05 1998-05-19 Dainippon Pharmaceut Co Ltd Medicine comprising acetic acid amide derivative
GB9619284D0 (en) 1996-09-16 1996-10-30 Celltech Therapeutics Ltd Chemical compounds
US6251911B1 (en) 1996-10-02 2001-06-26 Novartis Ag Pyrimidine derivatives and processes for the preparation thereof
EP0932598A1 (en) 1996-10-11 1999-08-04 Warner-Lambert Company ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME
BR9814817A (en) 1997-10-10 2002-01-08 Cytovia Inc Dipeptide apoptosis inhibitors and their use
US6267952B1 (en) * 1998-01-09 2001-07-31 Geltex Pharmaceuticals, Inc. Lipase inhibiting polymers
JP2000026421A (en) 1998-01-29 2000-01-25 Kumiai Chem Ind Co Ltd Diaryl sulfide derivative and pest controlling agent
JP2002503662A (en) 1998-02-17 2002-02-05 テュラリク インコーポレイテッド Antiviral pyrimidine derivatives
KR20010041905A (en) 1998-03-16 2001-05-25 시토비아 인크. Dipeptide caspase inhibitors and the use thereof
KR100722194B1 (en) 1998-06-02 2007-05-29 오에스아이 파마슈티컬스, 인코포레이티드 PYRROLO[2,3d]PYRIMIDINE COMPOSITIONS AND THEIR USE
WO1999065897A1 (en) 1998-06-19 1999-12-23 Chiron Corporation Inhibitors of glycogen synthase kinase 3
WO2000003901A1 (en) * 1998-07-16 2000-01-27 Continental Teves Ag & Co. Ohg Method and device for detecting the critical driving states in vehicles which are being driven
EP1105394A1 (en) * 1998-08-21 2001-06-13 Du Pont Pharmaceuticals Company ISOXAZOLO 4,5-d]PYRIMIDINES AS CRF ANTAGONISTS
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
EP1119567B1 (en) 1998-10-08 2005-05-04 AstraZeneca AB Quinazoline derivatives
GB9828640D0 (en) 1998-12-23 1999-02-17 Smithkline Beecham Plc Novel method and compounds
GB9828511D0 (en) * 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
WO2000042029A1 (en) 1999-01-13 2000-07-20 Warner-Lambert Company 1-heterocycle substituted diarylamines
ATE329596T1 (en) 1999-03-30 2006-07-15 Novartis Pharma Gmbh PHTHALAZINE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES
EP1185528A4 (en) 1999-06-17 2003-03-26 Shionogi Biores Corp Inhibitors of il-12 production
GB9914258D0 (en) * 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
CZ2002534A3 (en) 1999-08-13 2002-07-17 Vertex Pharmaceuticals Incorporated Inhibitors of protein-kinases, pharmaceutical preparations in which they are comprised as well as their use
EP1218360B1 (en) * 1999-10-07 2008-05-28 Amgen Inc., Triazine kinase inhibitors
CA2392971C (en) 1999-11-30 2008-10-07 Pfizer Products Inc. 2,4-diaminopyrimidine compounds useful as immunosuppressants
MXPA02005357A (en) 1999-12-02 2003-05-19 Osi Pharm Inc Compounds specific to adenosine a1.
US6376489B1 (en) 1999-12-23 2002-04-23 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
MY125768A (en) 1999-12-15 2006-08-30 Bristol Myers Squibb Co N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases
US20020065270A1 (en) 1999-12-28 2002-05-30 Moriarty Kevin Joseph N-heterocyclic inhibitors of TNF-alpha expression
JP4783532B2 (en) * 2000-02-05 2011-09-28 バーテックス ファーマシューティカルズ インコーポレイテッド Pyrazole compositions useful as inhibitors of ERK
MXPA02007957A (en) * 2000-02-17 2002-11-29 Amgen Inc Kinase inhibitors.
GB0004887D0 (en) * 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004890D0 (en) * 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
ATE297946T1 (en) 2000-04-03 2005-07-15 Vertex Pharma INHIBITORS OF SERINE PROTEASES, SPECIFICALLY THE HEPATITIS C VIRUS NS3 PROTEASE
BR0110302A (en) 2000-04-18 2003-01-14 Agouron Pharma Pyrazole compounds for protein kinase inhibition, pharmaceutically acceptable salt and prodrug, pharmaceutically active metabolite or pharmaceutically acceptable salt of metabolite, pharmaceutical composition, method of treating disease in mammals mediated by protein kinase activity, modulation or inhibition method of the activity of a protein kinase receptor
JP3890184B2 (en) * 2000-05-15 2007-03-07 Necパーソナルプロダクツ株式会社 Power supply device, power control method thereof, and information processing apparatus
US6919338B2 (en) * 2000-06-28 2005-07-19 Astrazeneca Ab Substituted quinazoline derivatives and their use as inhibitors of aurora-2 kinase
IL154016A0 (en) 2000-08-31 2003-07-31 Pfizer Prod Inc Pyrazole derivatives and their use as protein kinase inhibitors
CA2422376A1 (en) * 2000-09-15 2002-03-21 Vertex Pharmaceuticals Incorporated Isoxazoles and their use as inhibitors of erk
US6613776B2 (en) * 2000-09-15 2003-09-02 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US6610677B2 (en) * 2000-09-15 2003-08-26 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US7473691B2 (en) * 2000-09-15 2009-01-06 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US6660731B2 (en) * 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
ATE326458T1 (en) 2000-09-15 2006-06-15 Vertex Pharma PYRAZOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS
CA2422488A1 (en) 2000-09-20 2002-03-28 Merck Patent Gesellschaft Mit Beschraenkter Haftung 4-amino-quinazolines
US6641579B1 (en) * 2000-09-29 2003-11-04 Spectrasonics Imaging, Inc. Apparatus and method for ablating cardiac tissue
AU2002228922A1 (en) 2000-12-12 2002-06-24 Cytovia, Inc. Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators of caspases and inducers of apoptosis and the use thereof
US6716851B2 (en) * 2000-12-12 2004-04-06 Cytovia, Inc. Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators or caspases and inducers of apoptosis and the use thereof
DE10061863A1 (en) * 2000-12-12 2002-06-13 Basf Ag Preparation of triethylenediamine, useful for making pharmaceuticals and polymers, by reacting ethylenediamine over specific zeolite catalyst
DK1353916T3 (en) * 2000-12-21 2007-01-29 Vertex Pharma Pyrazole Compounds Suitable as Protein Kinase Inhibitors
MY130778A (en) * 2001-02-09 2007-07-31 Vertex Pharma Heterocyclic inhibitiors of erk2 and uses thereof
JP4160401B2 (en) 2001-03-29 2008-10-01 バーテックス ファーマシューティカルズ インコーポレイテッド Inhibitors of C-JUNN terminal kinase (JNK) and other protein kinases
ATE339416T1 (en) * 2001-04-13 2006-10-15 Vertex Pharma INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES
EP1383771A1 (en) * 2001-04-20 2004-01-28 Vertex Pharmaceuticals Incorporated 9-deazaguanine derivatives as inhibitors of gsk-3
AU2002308748A1 (en) * 2001-05-16 2002-11-25 Vertex Pharmaceuticals Incorporated Heterocyclic substituted pyrazoles as inhibitors of src and other protein kinases
DE60232510D1 (en) * 2001-06-15 2009-07-16 Vertex Pharma 5- (2-AMINOPYRIMIDIN-4-YL) BENZOXOXOLEA AS PROTEIN KINASE INHIBITOR
WO2003004492A1 (en) * 2001-07-03 2003-01-16 Vertex Pharmaceuticals Incorporated Isoxazolyl-pyrimidines as inhibitors of src and lck protein kinases
WO2003026664A1 (en) * 2001-09-26 2003-04-03 Bayer Corporation 2-phenylamino-4- (5-pyrazolylamino) -pyramidine derivatives as kinase inhibitors, in particular, src kinase inhibitors
US6569499B2 (en) * 2001-10-02 2003-05-27 Xerox Corporation Apparatus and method for coating photoreceptor substrates
AU2002364536B2 (en) * 2001-12-07 2008-10-23 Vertex Pharmaceuticals, Inc. Pyrimidine-based compounds useful as GSK-3 inhibitors
ATE433973T1 (en) * 2002-03-15 2009-07-15 Vertex Pharma AZOLYLAMINOAZINES AS INHIBITORS OF PROTEIN KINASES
EP1485100B1 (en) * 2002-03-15 2010-05-05 Vertex Pharmaceuticals Incorporated Azinylaminoazoles as inhibitors of protein kinases
US20040009981A1 (en) * 2002-03-15 2004-01-15 David Bebbington Compositions useful as inhibitors of protein kinases
AU2003220300A1 (en) * 2002-03-15 2003-09-29 Binch, Hayley Compositions useful as inhibitors of protein kinases
US20030207873A1 (en) * 2002-04-10 2003-11-06 Edmund Harrington Inhibitors of Src and other protein kinases
EP1506189A1 (en) * 2002-04-26 2005-02-16 Vertex Pharmaceuticals Incorporated Pyrrole derivatives as inhibitors of erk2 and uses thereof
MY141867A (en) 2002-06-20 2010-07-16 Vertex Pharma Substituted pyrimidines useful as protein kinase inhibitors
CA2491895C (en) * 2002-07-09 2011-01-18 Vertex Pharmaceuticals Incorporated Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases
CN101037438A (en) 2002-08-02 2007-09-19 沃泰克斯药物股份有限公司 Compositions useful as inhibitors of GSK-3
DE602007007985D1 (en) 2006-12-19 2010-09-02 Vertex Pharma AS INHIBITORS OF PROTEIN KINASES SUITABLE AMINO-PRIMIDINES

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