AR013081A1 - Derivados multiciclicos de eritromicina procedimiento para su preparacion, composicion farmaceutica que los comprende, y el uso de los mismos en lamanufactura de un medicamento - Google Patents
Derivados multiciclicos de eritromicina procedimiento para su preparacion, composicion farmaceutica que los comprende, y el uso de los mismos en lamanufactura de un medicamentoInfo
- Publication number
- AR013081A1 AR013081A1 ARP980102489A ARP980102489A AR013081A1 AR 013081 A1 AR013081 A1 AR 013081A1 AR P980102489 A ARP980102489 A AR P980102489A AR P980102489 A ARP980102489 A AR P980102489A AR 013081 A1 AR013081 A1 AR 013081A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- multicyclic
- erythromycin
- viii
- vii
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Lcompuestos multicíclicos de eritromicina nuevos y sales y ésteres farmacéuticamente aceptables de los mismos que tienen actividad bacterianatienen las formulas (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X), (XI),combinac ion con un portador farmacéuticamente aceptable, comoasí también el uso de derivados multicíclicos de eritromicina para la manufactura de un medicamento util para tratar infecciones bacterianasmediante una composicion farmacéuticaque conte nga una cantidad terapéuticamente efectiva de un compuesto de formula (I), donde cada A, B, D yE es independientemente un grupo con la formula -(CH2)m-M-(CH2)n-X, que se caracteriza porque: m es 0, 1, 2 o 3; n es 0, 1o 3; M está ausente o esseleccionado del grupo formado por (i) -O-; (ii) -NH-; (iii) -NH4-, que se caracteriza porque R4 es alquilo C1-6, opcionalmente sustituido con halogeno,arilo o heteroarilo; (iv) -S(O)q- que se caracteriza porque q es 0,1 o 2; (v) -C(O)-; (vi) -C(O)-NH-; (vii) -NH-C(O)-; (viii) -C(O)-O-; 8ix) -O-C(O)-; (x)-CH=CH-; (xi) -C=C-; y X es seleccionado del grupo formado por: (i) H; (ii) CN; (iii) halogeno; (iv) NO2; (v) arilo; (vi) arilo sustituido; (vii)heteroarilo;(viii) heteroari lo sustituido; (ix) heterocicloalquilo; y (x) cicloalquilo C3-7; (xi) alquilo C1-6; (xii) acilo C1-6; o un par de A, B, D y E,seleccionado del grupo formado por A&B, B&D y D&E, pueden, cuando dichascombinaciones son posibles, combinarse además con los átomos a los cuales losmismos se adhieren para formar un anillo seleccionado del grupo formado por benceno, piridina, piridazina, pirimidina, pirazina, pirazol, imidazol,triazol, pirrol,furano, tiofeno, oxazol, 1,3-dioxociclopent- 2-eno y 1,4- dioxociclohex-2-eno; R1 es seleccionado del grupo formado por: (a) hidrogeno
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86545397A | 1997-05-29 | 1997-05-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR013081A1 true AR013081A1 (es) | 2000-12-13 |
Family
ID=25345545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980102489A AR013081A1 (es) | 1997-05-29 | 1998-05-28 | Derivados multiciclicos de eritromicina procedimiento para su preparacion, composicion farmaceutica que los comprende, y el uso de los mismos en lamanufactura de un medicamento |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP0984975B1 (es) |
| JP (1) | JP4368950B2 (es) |
| KR (1) | KR20010013041A (es) |
| CN (1) | CN1258299A (es) |
| AR (1) | AR013081A1 (es) |
| AT (1) | ATE238330T1 (es) |
| AU (1) | AU7591298A (es) |
| BG (1) | BG103985A (es) |
| BR (1) | BR9809489A (es) |
| CA (1) | CA2290421C (es) |
| CO (1) | CO4950620A1 (es) |
| DE (1) | DE69813798T2 (es) |
| DK (1) | DK0984975T3 (es) |
| ES (1) | ES2197472T3 (es) |
| HU (1) | HUP0004809A3 (es) |
| IL (1) | IL132482A0 (es) |
| MX (1) | MXPA99011001A (es) |
| NO (1) | NO995842L (es) |
| NZ (1) | NZ500531A (es) |
| PL (1) | PL337066A1 (es) |
| PT (1) | PT984975E (es) |
| SI (1) | SI0984975T1 (es) |
| SK (1) | SK160299A3 (es) |
| TR (1) | TR199902820T2 (es) |
| WO (1) | WO1998054197A1 (es) |
| ZA (1) | ZA984488B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE250076T1 (de) * | 1999-06-07 | 2003-10-15 | Abbott Lab | 6-o-carbamat ketolide derivate |
| US20100035832A1 (en) * | 2005-01-12 | 2010-02-11 | Alpharma Aps | Macrolides |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE145212T1 (de) * | 1992-04-22 | 1996-11-15 | Taisho Pharmaceutical Co Ltd | 5-0-desosaminylerythronolide a derivate |
| ES2218604T3 (es) * | 1995-11-08 | 2004-11-16 | Abbott Laboratories | Derivados triciclicos de eritromicina. |
-
1998
- 1998-05-22 BR BR9809489-0A patent/BR9809489A/pt not_active IP Right Cessation
- 1998-05-22 SK SK1602-99A patent/SK160299A3/sk unknown
- 1998-05-22 KR KR1019997011017A patent/KR20010013041A/ko not_active Application Discontinuation
- 1998-05-22 CN CN98805510A patent/CN1258299A/zh active Pending
- 1998-05-22 TR TR1999/02820T patent/TR199902820T2/xx unknown
- 1998-05-22 CA CA002290421A patent/CA2290421C/en not_active Expired - Fee Related
- 1998-05-22 NZ NZ500531A patent/NZ500531A/en unknown
- 1998-05-22 SI SI9830449T patent/SI0984975T1/xx unknown
- 1998-05-22 AT AT98923678T patent/ATE238330T1/de not_active IP Right Cessation
- 1998-05-22 MX MXPA99011001A patent/MXPA99011001A/es not_active IP Right Cessation
- 1998-05-22 WO PCT/US1998/010501 patent/WO1998054197A1/en not_active Application Discontinuation
- 1998-05-22 PT PT98923678T patent/PT984975E/pt unknown
- 1998-05-22 AU AU75912/98A patent/AU7591298A/en not_active Abandoned
- 1998-05-22 PL PL98337066A patent/PL337066A1/xx unknown
- 1998-05-22 HU HU0004809A patent/HUP0004809A3/hu unknown
- 1998-05-22 DE DE69813798T patent/DE69813798T2/de not_active Expired - Fee Related
- 1998-05-22 ES ES98923678T patent/ES2197472T3/es not_active Expired - Lifetime
- 1998-05-22 IL IL13248298A patent/IL132482A0/xx unknown
- 1998-05-22 DK DK98923678T patent/DK0984975T3/da active
- 1998-05-22 JP JP50078099A patent/JP4368950B2/ja not_active Expired - Fee Related
- 1998-05-22 EP EP98923678A patent/EP0984975B1/en not_active Expired - Lifetime
- 1998-05-26 ZA ZA984488A patent/ZA984488B/xx unknown
- 1998-05-27 CO CO98029719A patent/CO4950620A1/es unknown
- 1998-05-28 AR ARP980102489A patent/AR013081A1/es unknown
-
1999
- 1999-11-29 NO NO995842A patent/NO995842L/no not_active Application Discontinuation
- 1999-12-10 BG BG103985A patent/BG103985A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2197472T3 (es) | 2004-01-01 |
| JP4368950B2 (ja) | 2009-11-18 |
| DK0984975T3 (da) | 2003-08-11 |
| PL337066A1 (en) | 2000-07-31 |
| WO1998054197A1 (en) | 1998-12-03 |
| JP2002500669A (ja) | 2002-01-08 |
| EP0984975A1 (en) | 2000-03-15 |
| EP0984975B1 (en) | 2003-04-23 |
| NO995842L (no) | 2000-01-26 |
| CO4950620A1 (es) | 2000-09-01 |
| BG103985A (en) | 2000-07-31 |
| NZ500531A (en) | 2001-07-27 |
| DE69813798D1 (en) | 2003-05-28 |
| DE69813798T2 (de) | 2004-02-19 |
| SK160299A3 (en) | 2000-06-12 |
| HUP0004809A3 (en) | 2001-11-28 |
| ATE238330T1 (de) | 2003-05-15 |
| CN1258299A (zh) | 2000-06-28 |
| TR199902820T2 (xx) | 2000-04-21 |
| MXPA99011001A (es) | 2003-09-10 |
| PT984975E (pt) | 2003-09-30 |
| AU7591298A (en) | 1998-12-30 |
| CA2290421A1 (en) | 1998-12-03 |
| NO995842D0 (no) | 1999-11-29 |
| IL132482A0 (en) | 2001-03-19 |
| ZA984488B (en) | 1998-12-02 |
| SI0984975T1 (en) | 2004-02-29 |
| KR20010013041A (ko) | 2001-02-26 |
| CA2290421C (en) | 2007-05-08 |
| BR9809489A (pt) | 2000-06-20 |
| HUP0004809A2 (hu) | 2001-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |