BR0011585A - Compostos de diaminotiazol,pró-droga farmaceuticamente aceitável,metabólito farmaceuticamente ativo ou sal farmaceuticamente aceitável,composição farmacêutica,método de tratamento de uma condição de doença de mamìferos mediada por atividade de cinase de proteìna e método de modulação da atividade de um receptor de cinase de proteìna - Google Patents
Compostos de diaminotiazol,pró-droga farmaceuticamente aceitável,metabólito farmaceuticamente ativo ou sal farmaceuticamente aceitável,composição farmacêutica,método de tratamento de uma condição de doença de mamìferos mediada por atividade de cinase de proteìna e método de modulação da atividade de um receptor de cinase de proteìnaInfo
- Publication number
- BR0011585A BR0011585A BR0011585-1A BR0011585A BR0011585A BR 0011585 A BR0011585 A BR 0011585A BR 0011585 A BR0011585 A BR 0011585A BR 0011585 A BR0011585 A BR 0011585A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- pharmaceutically acceptable
- activity
- protein
- treating
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Abstract
"COMPOSTOS DE DIAMINOTIAZOL, PRó-DROGA FARMACEUTICAMENTE ACEITáVEL, METABóLITO FARMACEUTICAMENTE ATIVO OU SAL FARMACEUTICAMENTE ACEITáVEL, COMPOSIçãO FARMACêUTICA, MéTODO DE TRATAMENTO DE UMA CONDIçãO DE DOENçA DE MAMìFEROS MEDIADA POR ATIVIDADE DE CINASE DE PROTEìNA E MéTODO DE MODULAçãO DA ATIVIDADE DE UM RECEPTOR DE CINASE DE PROTEìNA". A presente invenção refere-se a compostos de diaminotiazol de Fórmula (1) que modulam e/ou inibem a atividade de certas cinases de proteínas. Estes compostos e composições farmacêuticas que os contêm são capazes de mediar a transdução do sinal da tirosina cinase no sentido de modular elou inibir a proliferação celular indesejada. A invenção também se refere ao uso profilático ou terapêutico desses compostos e composições e a métodos de tratamento de câncer, bem como outros estados de doenças associadas com angiogênese indesejada elou proliferação celular, tais como retinopatia diabética, glaucoma neovascular, artrite reumatóide e psoríase, através da administração de quantidades eficazes desses compostos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13781099P | 1999-06-04 | 1999-06-04 | |
PCT/US2000/015188 WO2000075120A1 (en) | 1999-06-04 | 2000-06-02 | Diaminothiazoles and their use for inhibiting protein kinases |
Publications (1)
Publication Number | Publication Date |
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BR0011585A true BR0011585A (pt) | 2002-03-19 |
Family
ID=22479135
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0011585-1A BR0011585A (pt) | 1999-06-04 | 2000-06-02 | Compostos de diaminotiazol,pró-droga farmaceuticamente aceitável,metabólito farmaceuticamente ativo ou sal farmaceuticamente aceitável,composição farmacêutica,método de tratamento de uma condição de doença de mamìferos mediada por atividade de cinase de proteìna e método de modulação da atividade de um receptor de cinase de proteìna |
Country Status (34)
Country | Link |
---|---|
US (1) | US6620828B2 (pt) |
EP (1) | EP1181283B1 (pt) |
JP (1) | JP2003501420A (pt) |
KR (1) | KR20020015333A (pt) |
CN (1) | CN1359380A (pt) |
AP (1) | AP2001002341A0 (pt) |
AT (1) | ATE288424T1 (pt) |
AU (1) | AU778071B2 (pt) |
BG (1) | BG106276A (pt) |
BR (1) | BR0011585A (pt) |
CA (1) | CA2371158A1 (pt) |
CZ (1) | CZ20014213A3 (pt) |
DE (1) | DE60017894T2 (pt) |
EA (1) | EA200101268A1 (pt) |
EE (1) | EE200100659A (pt) |
ES (1) | ES2234628T3 (pt) |
HR (1) | HRP20020008A2 (pt) |
HU (1) | HUP0202897A3 (pt) |
IL (1) | IL146094A0 (pt) |
IS (1) | IS6183A (pt) |
MA (1) | MA25530A1 (pt) |
MX (1) | MXPA01012483A (pt) |
NO (1) | NO20015045L (pt) |
NZ (1) | NZ514881A (pt) |
OA (1) | OA11959A (pt) |
PE (1) | PE20010211A1 (pt) |
PL (1) | PL352714A1 (pt) |
SK (1) | SK17302001A3 (pt) |
SV (1) | SV2002000096A (pt) |
UA (1) | UA71971C2 (pt) |
UY (1) | UY26190A1 (pt) |
WO (1) | WO2000075120A1 (pt) |
YU (1) | YU85601A (pt) |
ZA (1) | ZA200108291B (pt) |
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US6040321A (en) * | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
DE69923681T2 (de) * | 1998-06-18 | 2006-01-12 | Bristol-Myers Squibb Co. | Kohlenstoff substituierte aminothiazole als inhibitoren von cyclin-abhängigen kinasen |
BR9914167B1 (pt) | 1998-09-29 | 2011-03-09 | compostos e composições farmacêuticas compreendendo 3-ciano quinolinas substituìdas. |
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2000
- 2000-02-06 UA UA2001129215A patent/UA71971C2/uk unknown
- 2000-06-02 CN CN00808440A patent/CN1359380A/zh active Pending
- 2000-06-02 BR BR0011585-1A patent/BR0011585A/pt not_active IP Right Cessation
- 2000-06-02 AU AU57254/00A patent/AU778071B2/en not_active Ceased
- 2000-06-02 MX MXPA01012483A patent/MXPA01012483A/es not_active Application Discontinuation
- 2000-06-02 AP APAP/P/2001/002341A patent/AP2001002341A0/en unknown
- 2000-06-02 PE PE2000000553A patent/PE20010211A1/es not_active Application Discontinuation
- 2000-06-02 EP EP00942660A patent/EP1181283B1/en not_active Expired - Lifetime
- 2000-06-02 CA CA002371158A patent/CA2371158A1/en not_active Abandoned
- 2000-06-02 SK SK1730-2001A patent/SK17302001A3/sk unknown
- 2000-06-02 DE DE60017894T patent/DE60017894T2/de not_active Expired - Fee Related
- 2000-06-02 YU YU85601A patent/YU85601A/sh unknown
- 2000-06-02 KR KR1020017015384A patent/KR20020015333A/ko not_active Application Discontinuation
- 2000-06-02 AT AT00942660T patent/ATE288424T1/de not_active IP Right Cessation
- 2000-06-02 WO PCT/US2000/015188 patent/WO2000075120A1/en not_active Application Discontinuation
- 2000-06-02 PL PL00352714A patent/PL352714A1/xx not_active Application Discontinuation
- 2000-06-02 ES ES00942660T patent/ES2234628T3/es not_active Expired - Lifetime
- 2000-06-02 JP JP2001501601A patent/JP2003501420A/ja not_active Abandoned
- 2000-06-02 EE EEP200100659A patent/EE200100659A/xx unknown
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- 2000-06-02 NZ NZ514881A patent/NZ514881A/en unknown
- 2000-06-02 EA EA200101268A patent/EA200101268A1/ru unknown
- 2000-06-02 CZ CZ20014213A patent/CZ20014213A3/cs unknown
- 2000-06-02 HU HU0202897A patent/HUP0202897A3/hu unknown
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- 2000-06-02 UY UY26190A patent/UY26190A1/es not_active Application Discontinuation
- 2000-06-02 SV SV2000000096A patent/SV2002000096A/es unknown
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2001
- 2001-02-15 US US09/783,584 patent/US6620828B2/en not_active Expired - Fee Related
- 2001-10-09 ZA ZA200108291A patent/ZA200108291B/xx unknown
- 2001-10-17 NO NO20015045A patent/NO20015045L/no not_active Application Discontinuation
- 2001-11-29 IS IS6183A patent/IS6183A/is unknown
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2002
- 2002-01-02 MA MA26465A patent/MA25530A1/fr unknown
- 2002-01-03 BG BG106276A patent/BG106276A/bg unknown
- 2002-01-04 HR HR20020008A patent/HRP20020008A2/hr not_active Application Discontinuation
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