ES2188595T3 - Derivados del acido 1-(2-oxo-acetil)-piperidin-2-carboxilico como sensibilizadores de celulas cancerosas resistentes a multiples farmacos. - Google Patents

Derivados del acido 1-(2-oxo-acetil)-piperidin-2-carboxilico como sensibilizadores de celulas cancerosas resistentes a multiples farmacos.

Info

Publication number
ES2188595T3
ES2188595T3 ES93922748T ES93922748T ES2188595T3 ES 2188595 T3 ES2188595 T3 ES 2188595T3 ES 93922748 T ES93922748 T ES 93922748T ES 93922748 T ES93922748 T ES 93922748T ES 2188595 T3 ES2188595 T3 ES 2188595T3
Authority
ES
Spain
Prior art keywords
carboxilico
piperidin
oxo
acetyl
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93922748T
Other languages
English (en)
Inventor
David M Armistead
Jeffrey O Saunders
Joshua S Boger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2188595T3 publication Critical patent/ES2188595T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

LA PRESENTE INVENCION EXPONE UNOS NUEVOS COMPONENTES DE FORMULA (I) QUE MANTIENEN, INCREMENTAN O RESTABLECEN LA SENSIBILIDAD DE CELULAS DE AGENTES TERAPEUTICOS O PROFILACTICOS. ESTA INVENCION TAMBIEN EXPONE COMPOSICIONES FARMACEUTICAS QUE COMPRENDEN ESTOS COMPONENTES. LOS COMPONENTES Y LAS COMPOSICIONES FARMACEUTICAS DE ESTA INVENCION ESTAN PARTICULARMENTE BIEN ADAPTADAS PARA EL TRATAMIENTO DE CELULAS MULTI-DROGORRESISTENTES PARA LA PREVENCION DEL DESARROLLO DE MULTIDROGORRESISTENCIA Y PARA EL USO EN TERAPIA DE CANCER MULTIDROGORRESISTENTE.
ES93922748T 1992-09-28 1993-09-27 Derivados del acido 1-(2-oxo-acetil)-piperidin-2-carboxilico como sensibilizadores de celulas cancerosas resistentes a multiples farmacos. Expired - Lifetime ES2188595T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95229992A 1992-09-28 1992-09-28

Publications (1)

Publication Number Publication Date
ES2188595T3 true ES2188595T3 (es) 2003-07-01

Family

ID=25492759

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93922748T Expired - Lifetime ES2188595T3 (es) 1992-09-28 1993-09-27 Derivados del acido 1-(2-oxo-acetil)-piperidin-2-carboxilico como sensibilizadores de celulas cancerosas resistentes a multiples farmacos.

Country Status (30)

Country Link
EP (1) EP0662958B1 (es)
JP (1) JP3635493B2 (es)
KR (1) KR100300112B1 (es)
CN (2) CN1494906A (es)
AT (1) ATE229506T1 (es)
AU (1) AU690082B2 (es)
BG (1) BG62729B1 (es)
CA (1) CA2144962C (es)
CZ (1) CZ287396B6 (es)
DE (1) DE69332563T2 (es)
DK (1) DK0662958T3 (es)
ES (1) ES2188595T3 (es)
FI (1) FI951454A (es)
HK (1) HK1013992A1 (es)
HU (1) HUT72046A (es)
IL (1) IL107109A (es)
IS (1) IS4073A (es)
MX (1) MX9305934A (es)
MY (1) MY119483A (es)
NO (1) NO305596B1 (es)
NZ (2) NZ314207A (es)
PL (1) PL308217A1 (es)
PT (1) PT662958E (es)
RO (1) RO117791B1 (es)
RU (1) RU2158258C2 (es)
SG (1) SG47517A1 (es)
SK (1) SK284129B6 (es)
TW (1) TW304943B (es)
UA (1) UA63874C2 (es)
WO (1) WO1994007858A1 (es)

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US5846981A (en) * 1993-05-28 1998-12-08 Gpi Nil Holdings Inc. Inhibitors of rotamase enzyme activity
US5744485A (en) * 1994-03-25 1998-04-28 Vertex Pharmaceuticals Incorporated Carbamates and ureas as modifiers of multi-drug resistance
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US5717092A (en) * 1996-03-29 1998-02-10 Vertex Pharmaceuticals Inc. Compounds with improved multi-drug resistance activity
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US5786378A (en) * 1996-09-25 1998-07-28 Gpi Nil Holdings, Inc. Heterocyclic thioesters
US5801187A (en) * 1996-09-25 1998-09-01 Gpi-Nil Holdings, Inc. Heterocyclic esters and amides
EP0959882A4 (en) 1996-12-31 2001-12-05 N-LINKED UREAS AND CARBAMATES OF HETEROCYCLIC THIOESTERS
US5935989A (en) 1996-12-31 1999-08-10 Gpi Nil Holdings Inc. N-linked ureas and carbamates of heterocyclic thioesters
US5846979A (en) 1997-02-28 1998-12-08 Gpi Nil Holdings, Inc. N-oxides of heterocyclic esters, amides, thioesters, and ketones
US6271244B1 (en) 1998-06-03 2001-08-07 Gpi Nil Holdings, Inc. N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
US5945441A (en) 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
US6187796B1 (en) 1998-06-03 2001-02-13 Gpi Nil Holdings, Inc. Sulfone hair growth compositions and uses
US6274602B1 (en) 1998-06-03 2001-08-14 Gpi Nil Holdings, Inc. Heterocyclic thioester and ketone hair growth compositions and uses
US6187784B1 (en) 1998-06-03 2001-02-13 Gpi Nil Holdings, Inc. Pipecolic acid derivative hair growth compositions and uses
US6268384B1 (en) 1997-08-29 2001-07-31 Vertex Pharmaceuticals Incorporated Compounds possessing neuronal activity
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US6172087B1 (en) 1998-06-03 2001-01-09 Gpi Nil Holding, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
WO1999062487A1 (en) 1998-06-03 1999-12-09 Gpi Nil Holdings, Inc. Heterocyclic ester and amide hair growth compositions and uses
US6399648B1 (en) 1998-08-14 2002-06-04 Gpi Nil Holdings, Inc. N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US6376517B1 (en) 1998-08-14 2002-04-23 Gpi Nil Holdings, Inc. Pipecolic acid derivatives for vision and memory disorders
US6218423B1 (en) 1998-08-14 2001-04-17 Gpi Nil Holdings, Inc. Pyrrolidine derivatives for vision and memory disorders
US6384056B1 (en) 1998-08-14 2002-05-07 Gpi Nil Holdings, Inc. Heterocyclic thioesters or ketones for vision and memory disorders
US6333340B1 (en) 1998-08-14 2001-12-25 Gpi Nil Holdings, Inc. Small molecule sulfonamides for vision and memory disorders
US7338976B1 (en) 1998-08-14 2008-03-04 Gpi Nil Holdings, Inc. Heterocyclic esters or amides for vision and memory disorders
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NZ314207A (en) * 1992-09-28 2000-12-22 Vertex Pharma 1-(2-Oxoacetyl)-piperidine-2-carboxylic acid derivatives as multi drug resistant cancer cell sensitizers

Also Published As

Publication number Publication date
DK0662958T3 (da) 2003-03-31
CN1088577A (zh) 1994-06-29
ATE229506T1 (de) 2002-12-15
RU95110938A (ru) 1997-01-10
KR100300112B1 (ko) 2001-10-22
DE69332563T2 (de) 2003-11-27
PT662958E (pt) 2003-04-30
MX9305934A (es) 1994-03-31
IL107109A (en) 1999-03-12
DE69332563D1 (de) 2003-01-23
RU2158258C2 (ru) 2000-10-27
NO305596B1 (no) 1999-06-28
CN1086386C (zh) 2002-06-19
FI951454A0 (fi) 1995-03-27
CN1494906A (zh) 2004-05-12
BG62729B1 (bg) 2000-06-30
JPH08502256A (ja) 1996-03-12
CA2144962C (en) 2003-05-20
FI951454A (fi) 1995-03-27
SG47517A1 (en) 1998-04-17
SK284129B6 (sk) 2004-09-08
CZ287396B6 (en) 2000-11-15
NO951162D0 (no) 1995-03-27
MY119483A (en) 2005-06-30
AU690082B2 (en) 1998-04-23
PL308217A1 (en) 1995-07-24
NZ256772A (en) 1997-03-24
IL107109A0 (en) 1993-12-28
NO951162L (no) 1995-05-29
HUT72046A (en) 1996-03-28
NZ314207A (en) 2000-12-22
EP0662958A1 (en) 1995-07-19
RO117791B1 (ro) 2002-07-30
UA63874C2 (en) 2004-02-16
WO1994007858A1 (en) 1994-04-14
HK1013992A1 (en) 1999-09-17
AU5164893A (en) 1994-04-26
TW304943B (es) 1997-05-11
BG99585A (bg) 1995-12-29
EP0662958B1 (en) 2002-12-11
SK38995A3 (en) 1995-08-09
CZ76995A3 (en) 1995-12-13
IS4073A (is) 1994-03-29
CA2144962A1 (en) 1994-04-14
JP3635493B2 (ja) 2005-04-06

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