ES2137353T3 - Nuevos derivados esteroides especificos del colon o del ileon. - Google Patents

Nuevos derivados esteroides especificos del colon o del ileon.

Info

Publication number
ES2137353T3
ES2137353T3 ES94904364T ES94904364T ES2137353T3 ES 2137353 T3 ES2137353 T3 ES 2137353T3 ES 94904364 T ES94904364 T ES 94904364T ES 94904364 T ES94904364 T ES 94904364T ES 2137353 T3 ES2137353 T3 ES 2137353T3
Authority
ES
Spain
Prior art keywords
ileon
steroid derivatives
colon
specific steroid
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94904364T
Other languages
English (en)
Inventor
Ralph Lennart Brattsand
Peter Edman
Thomas Hogberg
Stinabritt Nilsson
Bror Arne Thalen
Jan Erik Ulmius
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9300030A external-priority patent/SE9300030D0/xx
Priority claimed from SE9300082A external-priority patent/SE9300082D0/xx
Application filed by Astra AB filed Critical Astra AB
Application granted granted Critical
Publication of ES2137353T3 publication Critical patent/ES2137353T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

NUEVOS COMPUESTOS QUE SON UN GLUCOCORTICOESTEROIDE (GCS) QUIMICAMENTE UNIDO A UN AZUCAR, QUE TIENE LA FORMULA GENERAL GCS{SUP,1}-O-AZUCAR{SUP,1} PARA EL SUMINISTRO ESPECIFICO AL COLON O EL ILEON DEL GCS A LA MUCOSA DE INTESTINOS INFLAMADOS, ASI COMO PROCESOS PARA SU PREPARACION, PREPARACIONES FARMACEUTICAS QUE CONTIENEN LOS COMPUESTOS Y EL USO DE DICHOS COMPUESTOS EN UNA TERAPIA.
ES94904364T 1993-01-08 1993-12-17 Nuevos derivados esteroides especificos del colon o del ileon. Expired - Lifetime ES2137353T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9300030A SE9300030D0 (sv) 1993-01-08 1993-01-08 Novel colon- or ileum-specific steroid derivatives
SE9300082A SE9300082D0 (sv) 1993-01-14 1993-01-14 Novel colon- or ileum-specific steroid derivatives
PCT/SE1993/001081 WO1994015947A1 (en) 1993-01-08 1993-12-17 Novel colon- or ileum-specific steroid derivatives

Publications (1)

Publication Number Publication Date
ES2137353T3 true ES2137353T3 (es) 1999-12-16

Family

ID=26661623

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94904364T Expired - Lifetime ES2137353T3 (es) 1993-01-08 1993-12-17 Nuevos derivados esteroides especificos del colon o del ileon.

Country Status (22)

Country Link
US (2) US5908833A (es)
EP (1) EP0678097B1 (es)
JP (1) JP3366640B2 (es)
KR (1) KR960700266A (es)
AT (1) ATE183192T1 (es)
BR (1) BR9307746A (es)
CA (1) CA2152374A1 (es)
CZ (1) CZ171095A3 (es)
DK (1) DK0678097T3 (es)
ES (1) ES2137353T3 (es)
FI (1) FI953358A0 (es)
GR (1) GR3031789T3 (es)
HU (1) HU221584B (es)
IS (1) IS4111A (es)
LV (1) LV10961B (es)
NO (1) NO305367B1 (es)
NZ (1) NZ259596A (es)
PL (1) PL178307B1 (es)
RU (1) RU95115547A (es)
SK (1) SK87295A3 (es)
TW (1) TW261615B (es)
WO (1) WO1994015947A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2152374A1 (en) * 1993-01-08 1994-07-21 Ralph Lennart Brattsand Novel colon- or ileum-specific steroid derivatives
WO1995009177A1 (fr) * 1993-09-29 1995-04-06 Nissin Shokuhin Kabushiki Kaisha Compose steroide substitue en position 21
US6028190A (en) 1994-02-01 2000-02-22 The Regents Of The University Of California Probes labeled with energy transfer coupled dyes
US6166024A (en) 1995-03-30 2000-12-26 Mayo Foundation For Medical Education And Research Use of topical azathioprine and thioguanine to treat colorectal adenomas
JP4610734B2 (ja) * 1998-03-19 2011-01-12 三笠製薬株式会社 ２１−置換グリコシルステロイド化合物
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
ES2246234T3 (es) 1999-05-04 2006-02-16 Strakan International Limited Glicosidos de androgenos y actividad androgenica de los mismos.
US8895064B2 (en) 1999-06-14 2014-11-25 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
CN1173695C (zh) 1999-06-14 2004-11-03 科斯默股份公司 控制释放与掩蔽味道的口服药物组合物
WO2001051057A2 (en) * 2000-01-14 2001-07-19 Strakan Limited Glycosides and orthoester glycosides of glucocorticoids and uses thereof
SE0101220D0 (sv) * 2001-04-04 2001-04-04 Astrazeneca Ab New use
EP1625854B1 (en) * 2004-08-09 2008-10-15 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Albumin conjugates containing a glucuronic linker
US20080200441A1 (en) * 2007-02-14 2008-08-21 University Of Southern California Estrogen receptor modulators associated pharmaceutical compositions and methods of use
US10154964B2 (en) 2011-09-07 2018-12-18 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
JP7330101B2 (ja) 2016-11-08 2023-08-21 レゲネロン ファーマシューティカルス，インコーポレーテッド ステロイド及びそのタンパク質コンジュゲート
CN110650966B (zh) * 2017-03-30 2022-06-21 合肥合源药业有限公司 乳果糖糖苷化合物、其制备方法及其用途
AU2018270784B2 (en) 2017-05-18 2024-05-16 Regeneron Pharmaceuticals, Inc. Cyclodextrin protein drug conjugates
MA54673A1 (fr) * 2018-01-08 2022-08-31 Regeneron Pharma Stéroïdes et leurs conjugués-anticorps
KR20210008008A (ko) 2018-05-09 2021-01-20 리제너론 파마슈티칼스 인코포레이티드 항-msr1 항체 및 이의 사용 방법

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE378110B (es) * 1972-05-19 1975-08-18 Bofors Ab
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
US3992534A (en) * 1972-05-19 1976-11-16 Ab Bofors Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods
SE378109B (es) * 1972-05-19 1975-08-18 Bofors Ab
US3938233A (en) * 1974-08-12 1976-02-17 Cannon Robert B Heat transfer apparatus
BG33736A3 (en) * 1978-01-25 1983-04-15 Schering Ag,De Method for obtaining of substituated in 17- th position steroids from pregnan row
DE2803660A1 (de) * 1978-01-25 1979-07-26 Schering Ag Neue in 17-position substituierte steroide der pregnanreihe, ihre herstellung und verwendung
US4221787A (en) * 1978-03-28 1980-09-09 Interx Research Corporation Esteramide prodrugs of anti-inflammatory corticosteroids
SE8008524L (sv) * 1980-12-04 1982-06-05 Draco Ab 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
US4456602A (en) * 1982-08-23 1984-06-26 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4443440A (en) * 1982-08-30 1984-04-17 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4472392A (en) * 1983-01-21 1984-09-18 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
US4469689A (en) * 1983-03-30 1984-09-04 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
WO1984004041A1 (en) * 1983-04-14 1984-10-25 Univ California Colon-specific drug delivery system
US4959358A (en) * 1983-06-06 1990-09-25 Beth Israel Hospital Assn. Drug administration
US4548922A (en) * 1983-06-06 1985-10-22 Beth Israel Hospital Drug administration
SE8306370D0 (sv) * 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
US4588718A (en) * 1984-03-28 1986-05-13 The Upjohn Company Carboxy containing ester prodrugs of corticosteroids
SE8403905D0 (sv) * 1984-07-30 1984-07-30 Draco Ab Liposomes and steroid esters
US5215979A (en) * 1985-12-19 1993-06-01 Aktiebolaget Draco 16,17-acetalsubstituted pregnane 21-oic acid derivatives
GB8600490D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside norcholanic acid lactams
GB8600491D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside norcholanic acid derivatives
GB8600489D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside steroids
EP0267297B1 (en) * 1986-05-12 1993-09-15 Mect Corporation Sialosylcholesterol, process for its preparation, and drug for treating diseases of nervous system
CA1299653C (en) * 1988-07-07 1992-04-28 Markwell Medical Institute, Inc. Biological fluid measuring device
US5643602A (en) * 1989-11-22 1997-07-01 Astra Aktiebolag Oral composition for the treatment of inflammatory bowel disease
SE8903914D0 (sv) * 1989-11-22 1989-11-22 Draco Ab Oral composition for the treatment of inflammatory bowel diseases
SE9100342D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
US5888995A (en) * 1991-02-04 1999-03-30 Astra Aktiebolag Steroid esters
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
WO1993022334A1 (en) * 1992-05-04 1993-11-11 Sri International Pharmaceutical compositions and methods for colonic delivery of corticosteroids
CA2152374A1 (en) * 1993-01-08 1994-07-21 Ralph Lennart Brattsand Novel colon- or ileum-specific steroid derivatives

Also Published As

Publication number Publication date
BR9307746A (pt) 1995-11-14
US6140308A (en) 2000-10-31
WO1994015947A1 (en) 1994-07-21
CA2152374A1 (en) 1994-07-21
RU95115547A (ru) 1997-06-10
NZ259596A (en) 1997-04-24
LV10961B (en) 1996-08-20
HU9502087D0 (en) 1995-09-28
JPH08505616A (ja) 1996-06-18
DK0678097T3 (da) 2000-02-07
AU5844794A (en) 1994-08-15
AU678803B2 (en) 1997-06-12
GR3031789T3 (en) 2000-02-29
CZ171095A3 (en) 1996-01-17
NO952683L (no) 1995-07-06
EP0678097A1 (en) 1995-10-25
FI953358A (fi) 1995-07-07
JP3366640B2 (ja) 2003-01-14
TW261615B (es) 1995-11-01
US5908833A (en) 1999-06-01
NO305367B1 (no) 1999-05-18
LV10961A (lv) 1995-12-20
ATE183192T1 (de) 1999-08-15
NO952683D0 (no) 1995-07-06
KR960700266A (ko) 1996-01-19
IS4111A (is) 1994-07-09
FI953358A0 (fi) 1995-07-07
HUT73227A (en) 1996-07-29
PL309777A1 (en) 1995-11-13
EP0678097B1 (en) 1999-08-11
SK87295A3 (en) 1996-04-03
PL178307B1 (pl) 2000-04-28
HU221584B (hu) 2002-11-28

Similar Documents

Publication Publication Date Title
ES2137353T3 (es) Nuevos derivados esteroides especificos del colon o del ileon.
ES2188595T3 (es) Derivados del acido 1-(2-oxo-acetil)-piperidin-2-carboxilico como sensibilizadores de celulas cancerosas resistentes a multiples farmacos.
AU8296987A (en) Pharmaceutical composition comprising fluticasone propionate
HUP0200714A2 (hu) Gyógyhatású vegyületek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
ATE84032T1 (de) Benzimidazolderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate.
ATE45153T1 (de) Benzisoselenazolthione, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische produkte.
BR0012610A (pt) Novo derivado de difenilpiperidina
GR1002847B (el) Χρηση της μισοπροστολης ή/και της μισοπροστολης οξυ για την παρασκευη φαρμακευτικου προιοντος για τη θεραπευτικη αντιμετωπιση των δυσλειτουργιων της στυσεως
ATE13433T1 (de) Peptide als arzneimittel und einige peptide.
BR9809234A (pt) Composto, composição farmacêutica, uso de um composto, processos para tratar ou prevenir doenças do sistema endocrinológico, para fabricar um medicamento, para preparar um composto e um conjunto, conjunto, e, uso do mesmo.
SE8405588D0 (sv) New compounds
DE3781627D1 (de) Indanderivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, diese enthaltende pharmazeutische zusammensetzungen und erhaltene zwischenprodukte.
ES8304152A1 (es) Procedimiento para la obtencion de derivzados de aminociclitol.
MY104088A (en) Peptide-drugs compositions containing (alpha)-aminoboroic acid derivatives.
DE60237994D1 (de) 3.beta.,28-diacetoxy-18-oxo-19,20,21,29,30-pentanorlupan-22-säure solvate, verfahren zu ihrer herstellung und pharmazeutische präparate daraus
ATE55254T1 (de) Verminderung der toxischen wirkungen von anthrachinon-medikamenten.
DK1023059T3 (da) Farmaceutiske præparater
ATA263487A (de) Neue verbindungen, ihre herstellung und diese enthaltende pharmazeutische zubereitungen
TAMAI et al. Studies of intratissular concentration of antibiotics in oral surgery III. A basic experiment of prolino-methyl Tetracycline with special reference to its concentration in the jaw-bone and its clinical effects
ECSP951622A (es) Compuestos quimicos
ATE80393T1 (de) Indanderivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, diese enthaltende pharmazeutische zusammensetzungen und erhaltene zwischenprodukte.

Legal Events

Date Code Title Description
FC2A Grant refused

Effective date: 19950925

FG2A Definitive protection

Ref document number: 678097

Country of ref document: ES