ES2059789T3 - Esteroides sustituidos con acido fosfinico como inhibidores de la esteroide-5 alfa-reductasa. - Google Patents
Esteroides sustituidos con acido fosfinico como inhibidores de la esteroide-5 alfa-reductasa.Info
- Publication number
- ES2059789T3 ES2059789T3 ES89313262T ES89313262T ES2059789T3 ES 2059789 T3 ES2059789 T3 ES 2059789T3 ES 89313262 T ES89313262 T ES 89313262T ES 89313262 T ES89313262 T ES 89313262T ES 2059789 T3 ES2059789 T3 ES 2059789T3
- Authority
- ES
- Spain
- Prior art keywords
- inhibitors
- steroid
- reductase
- alpha
- phosphinic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/002—Expansion of ring A by one atom, e.g. A homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J61/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one or two atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
COMPONENTES DE ESTRUCTURA (I) EN EL QUE LAS LINEAS DOTADAS INDICAN LA PRESENCIA OPCIONAL DE ENLACES DOBLES Y, INTER ALIA, R1 ES H, R2 ES H O CH3 Y R3 ES H, HIDROXI O ACETOXI, PROCESOS PARA SU PREPARACION, COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y SU USO EN MEDICINA COMO INHIBIDORES DE REDUCTASA-A-5.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/290,212 US5026882A (en) | 1988-12-23 | 1988-12-23 | Phosphinic acid substituted steroids as inhibitors of steroid 5α-reductase |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2059789T3 true ES2059789T3 (es) | 1994-11-16 |
Family
ID=23114995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89313262T Expired - Lifetime ES2059789T3 (es) | 1988-12-23 | 1989-12-19 | Esteroides sustituidos con acido fosfinico como inhibidores de la esteroide-5 alfa-reductasa. |
Country Status (13)
Country | Link |
---|---|
US (1) | US5026882A (es) |
EP (1) | EP0375349B1 (es) |
JP (1) | JPH02215796A (es) |
AT (1) | ATE110735T1 (es) |
AU (1) | AU630139B2 (es) |
CA (1) | CA2005214A1 (es) |
DE (1) | DE68917884T2 (es) |
DK (1) | DK645389A (es) |
ES (1) | ES2059789T3 (es) |
HU (1) | HU205137B (es) |
IE (1) | IE894111L (es) |
PT (1) | PT92723A (es) |
ZA (1) | ZA899671B (es) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5571817A (en) * | 1984-02-27 | 1996-11-05 | Merck & Co., Inc. | Methods of treating androgenic alopecia with finasteride [17β-N-mono-substituted-carbamoyl-4-aza-5-α-androst-1-en-ones] |
US5138063A (en) * | 1984-02-27 | 1992-08-11 | Merck & Co., Inc. | 17β-methoxycarbonyl-4-aza-androsten-1-en-3-ones |
US4882319A (en) * | 1988-12-23 | 1989-11-21 | Smithkline Beckman Corporation | Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5-α-reductase |
US4970204A (en) * | 1989-08-23 | 1990-11-13 | Smithkline Beecham Corporation | 3-substituted nitro-steroid derivatives as 5-α-reductase inhibitors |
US5516768A (en) * | 1990-03-16 | 1996-05-14 | Smithkline Beecham Corporation | Uncompetitive inhibition of steroid and 5α-reductose |
US5098908A (en) * | 1990-06-20 | 1992-03-24 | Merck & Co., Inc. | 17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors |
US5162332A (en) * | 1990-06-20 | 1992-11-10 | Merck & Co., Inc. | Selected 17 β-polyaroyl-4-aza-5 α-androst-1-en-3-ones as steroidal reductase inhibitors |
US5151430A (en) * | 1990-06-20 | 1992-09-29 | Merck & Co., Inc. | Specific 17β-thiobenzoyl-4-aza-5α-androst-1-en-3-ones as antiandrogen agents |
US5061802A (en) * | 1990-06-20 | 1991-10-29 | Merck & Co. Inc. | 17β-aminobenzoyl-4-aza-5α-androst-1-en-3-ones as benign prostatic hypertrophy agents |
US5091380A (en) * | 1990-06-28 | 1992-02-25 | Merck & Co., Inc. | N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors |
CH681153A5 (de) * | 1991-01-28 | 1993-01-29 | Marigen S.A. | Neue sterolester- und sterolphosphorverbindungen. |
NZ241979A (en) * | 1991-03-20 | 1996-01-26 | Merck & Co Inc | Treatment of benign prostatic hyperplasia using 5alpha-reductase inhibitor and an alpha1-adrenergic recepter blocker |
EP0641204B1 (en) * | 1992-05-20 | 2000-08-16 | Merck & Co. Inc. | 17-ethers and thioethers of 4-aza-steroids |
SK137994A3 (en) * | 1992-05-20 | 1995-04-12 | Merck & Co Inc | 7-beta-substituted-4-aza-5-alpha-cholestan-ons their using for production of pharmaceutical agent and pharmaceutical agent containing them |
US5639741A (en) * | 1992-05-20 | 1997-06-17 | Merck & Co., Inc. | 17-amino substituted 4-azasteroid 5α-reductase inhibitors |
US5710275A (en) * | 1992-05-20 | 1998-01-20 | Merck & Co., Inc. | 7β-substituted-4-aza-5α-androstan-3-ones as 5α-reductase inhibitors |
ATE195129T1 (de) * | 1992-05-20 | 2000-08-15 | Merck & Co Inc | 4-azasteroide als 5-alpha-reduktase |
CA2135173A1 (en) * | 1992-05-20 | 1993-11-25 | Bruce E. Witzel | Ester derivatives of 4-aza-steroids |
US5237064A (en) * | 1992-05-20 | 1993-08-17 | Merck & Co., Inc. | Process for producing 7β-substituted-aza-5αandrostan-3-ones |
CZ286894A3 (en) * | 1992-05-21 | 1995-09-13 | Endorecherche Inc | Pharmaceutical preparation |
US5324734A (en) * | 1992-09-15 | 1994-06-28 | Merck & Co., Inc. | Oxidization metabolites of 5-α-23-methyl-4-aza-21-nor-chol-1-ene-3, 20-dione |
US5278159A (en) * | 1992-10-06 | 1994-01-11 | Merck & Co., Inc. | Aryl ester derivatives of 3-oxo-4-aza-androstane 17-β-carboxylates as 5-α-reductase inhibitors |
US5359071A (en) * | 1993-03-12 | 1994-10-25 | Merck & Co., Inc. | 15-substituted 4-azasteroids |
AU6413594A (en) * | 1993-03-24 | 1994-10-11 | Merck & Co., Inc. | Substituted 3-phenanthridinone derivatives as 5alpha-reductase inhibitors |
CA2165077A1 (en) * | 1993-06-28 | 1995-01-05 | Philippe L. Durette | 4-aza-pregnane 5.alpha.-reductase isozyme 1 inhibitors |
TW369521B (en) * | 1993-09-17 | 1999-09-11 | Smithkline Beecham Corp | Androstenone derivative |
US5541322A (en) * | 1994-10-14 | 1996-07-30 | Glaxo Wellcome Inc. | Synthesis of 6-azaandrostenones |
IL138645A0 (en) * | 1998-04-09 | 2001-10-31 | Univ Johns Hopkins Med | Use of steroidal alkaloid derivatives as inhibitors of hedghog signalling pathways |
US7291626B1 (en) | 1998-04-09 | 2007-11-06 | John Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
US6867216B1 (en) | 1998-04-09 | 2005-03-15 | Johns Hopkins University School Of Medicine | Inhibitors of hedgehog signal pathways, compositions and uses related thereto |
DE69942578D1 (de) | 1998-05-22 | 2010-08-26 | Univ R | Bifunktionelle moleküle sowie darauf basierende therapien. |
AU781524B2 (en) | 1999-10-13 | 2005-05-26 | Johns Hopkins University School Of Medicine, The | Regulators of the hedgehog pathway, compositions and uses related thereto |
EP2671508B1 (en) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Pharma-informatics system |
WO2007035716A2 (en) | 2005-09-16 | 2007-03-29 | Raptor Pharmaceutical Inc. | Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof |
AU2010216512B2 (en) | 2009-02-20 | 2016-06-30 | 2-Bbb Medicines B.V. | Glutathione-based drug delivery system |
EP2427178B1 (en) | 2009-05-06 | 2023-01-04 | Laboratory Skin Care, Inc. | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4191759A (en) * | 1978-04-13 | 1980-03-04 | Merck & Co., Inc. | N-substituted-17β-carbamoylandrost-4-en-3-one 5α reductase inhibitors |
US4377584A (en) * | 1978-04-13 | 1983-03-22 | Merck & Co., Inc. | 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors |
US4317817A (en) * | 1979-08-27 | 1982-03-02 | Richardson-Merrell Inc. | Novel steroid 5α-reductase inhibitors |
DK465481A (da) * | 1980-11-21 | 1982-05-22 | Hoffmann La Roche | Fremgangsmaade til fremstilling af d-homostemoider |
CA1252778A (en) * | 1983-08-25 | 1989-04-18 | Hoffmann-La Roche Limited/Hoffmann-La Roche Limitee | Steroids |
US4910226A (en) * | 1987-04-29 | 1990-03-20 | Smithkline Beckman Corporation | Steroid 5-alpha-reductase inhibitors |
US4882319A (en) * | 1988-12-23 | 1989-11-21 | Smithkline Beckman Corporation | Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5-α-reductase |
US4946834A (en) * | 1988-12-23 | 1990-08-07 | Smithkline Beecham Corporation | Phosphonic acid substituted steroids as steroid 5α-reductase inhibitors |
US4937237A (en) * | 1988-12-23 | 1990-06-26 | Smithkline Beckman Corporation | Phosphinic acid substituted aromatic steroids as inhibitors of steroid 5-60 -reductase |
-
1988
- 1988-12-23 US US07/290,212 patent/US5026882A/en not_active Expired - Fee Related
-
1989
- 1989-10-11 HU HU895286A patent/HU205137B/hu not_active IP Right Cessation
- 1989-12-12 CA CA002005214A patent/CA2005214A1/en not_active Abandoned
- 1989-12-18 ZA ZA899671A patent/ZA899671B/xx unknown
- 1989-12-19 ES ES89313262T patent/ES2059789T3/es not_active Expired - Lifetime
- 1989-12-19 EP EP89313262A patent/EP0375349B1/en not_active Expired - Lifetime
- 1989-12-19 AT AT89313262T patent/ATE110735T1/de not_active IP Right Cessation
- 1989-12-19 DK DK645389A patent/DK645389A/da not_active Application Discontinuation
- 1989-12-19 DE DE68917884T patent/DE68917884T2/de not_active Expired - Fee Related
- 1989-12-20 IE IE894111A patent/IE894111L/xx unknown
- 1989-12-20 AU AU47039/89A patent/AU630139B2/en not_active Ceased
- 1989-12-22 PT PT92723A patent/PT92723A/pt not_active Application Discontinuation
- 1989-12-22 JP JP1334672A patent/JPH02215796A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU4703989A (en) | 1990-06-28 |
EP0375349B1 (en) | 1994-08-31 |
DE68917884D1 (de) | 1994-10-06 |
JPH02215796A (ja) | 1990-08-28 |
ZA899671B (en) | 1990-11-28 |
HU205137B (en) | 1992-03-30 |
US5026882A (en) | 1991-06-25 |
HUT55795A (en) | 1991-06-28 |
DK645389D0 (da) | 1989-12-19 |
IE894111L (en) | 1990-06-23 |
DK645389A (da) | 1990-06-24 |
EP0375349A1 (en) | 1990-06-27 |
PT92723A (pt) | 1990-06-29 |
CA2005214A1 (en) | 1990-06-23 |
DE68917884T2 (de) | 1995-03-23 |
ATE110735T1 (de) | 1994-09-15 |
HU895286D0 (en) | 1990-01-28 |
AU630139B2 (en) | 1992-10-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2059789T3 (es) | Esteroides sustituidos con acido fosfinico como inhibidores de la esteroide-5 alfa-reductasa. | |
ES2066003T3 (es) | Esteroides aromaticos sustituidos con acido sulfonico como inhibidores del esteroide 5-alfa-reductasa. | |
IT8748014A0 (it) | Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico | |
MX9301929A (es) | Derivados de pirimidina y procedimientos para su preparacion. | |
IT8848730A0 (it) | Derivati 17beta-oh 19-nor steroidei sostituiti in 17alfa, procedimento di preparazione, loro impiego come medicamenti e composizioni farmaceutiche che li compongono | |
ES2075202T3 (es) | Nuevas arilpiridazinas, su preparacion, su utilizacion, y medicamentos que las contienen. | |
ES2058185T3 (es) | Derivados de camptotecina y procedimiento para su preparacion. | |
MX9206503A (es) | Nuevos derivados de lupano, proceso para su preparacion y composicion farmaceutica que los contiene. | |
ES2052603T3 (es) | Derivados de bencimidazol, procedimiento para su produccion y composicion farmaceutica que los contienen. | |
ES2051678T1 (es) | Derivados de 5-oxo-l-prolina y uso farmaceutico de los mismos. | |
ATE11417T1 (de) | Sterolinhalbester, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen. | |
ES2101230T3 (es) | Nuevos derivados de sustancias anti-inflamatorias, analgesicas y/o antipireticas no estereoideas, su uso y formulaciones farmaceuticas que las contienen. | |
IT8423564A0 (it) | Derivati della 7-carbossimetossi-furo-(3,4-c)-piri dina, loro preparazione e composizioni farmaceutiche che licontengono. | |
ES2088655T3 (es) | Esteres de l-carnitina y alcanoil l-carnitinas con acido glicolico o sus esteres y composiciones farmaceuticas que las contienen para tratar dermatosis. | |
MX9205916A (es) | Derivados de acido ciclohexanoacetico, proceso para su preparacion y composicion farmaceutica que los comprende | |
ES2058561T3 (es) | Esteroides sustituidos con acido fosfonico como inhibidores de la esteroide-5alfa-reductasa. | |
ES2059534T3 (es) | Nuevos derivados benzopiranos antihipertensivos. | |
AR241157A1 (es) | Derivados de la imida del acido n-fenil-3,4,5,6-tetrahidroftalico, procedimiento para su preparacion y composiciones que los contienen | |
ECSP941120A (es) | Derivados de 1,5 benzodiazepina | |
AR012946A1 (es) | Forma cristalina a de 1-(2,6-difluorbencil)-1h-1,2,3-triazol-4-carboxamida, preparaciones farmaceuticas que los contienen y su uso para la preparacion de medicamentos | |
ATE90355T1 (de) | Weiche steroide mit anti-entzuendungswirkung. | |
ES2018667B3 (es) | Derivados del acido 4-qionolon-3-carboxilico, procedimiento para su obtencion y preparados farmaceuticos que los contienen. | |
MX9303574A (es) | Compuestos heterociclicos que son inhibidores de la enzima aromatasa, proceso para su preparacion ycomposiciones farmaceuticas que los contienen. | |
IT1227456B (it) | Nuovi alcossi derivati di ginkgolidi, loro preparazione e composizioni terapeutiche che li contengono | |
ES2076248T3 (es) | Dibenzofuranos substituidos y metodos para el uso de los mismos. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 375349 Country of ref document: ES |