RU95115547A - Стероидные соединения, способы их получения и фармацевтический препарат - Google Patents

Стероидные соединения, способы их получения и фармацевтический препарат

Info

Publication number
RU95115547A
RU95115547A RU95115547/04A RU95115547A RU95115547A RU 95115547 A RU95115547 A RU 95115547A RU 95115547/04 A RU95115547/04 A RU 95115547/04A RU 95115547 A RU95115547 A RU 95115547A RU 95115547 A RU95115547 A RU 95115547A
Authority
RU
Russia
Prior art keywords
compounds
synthesis
methods
gcs
glucocorticosteroids
Prior art date
Application number
RU95115547/04A
Other languages
English (en)
Inventor
Леннарт Браттсанд Ральф
Se]
Эдман Петер
Хегберг Томас
Нильссон Стинабритт
Арне Тален Брор
Эрик Ульмиус Ян
Original Assignee
Астра Актиеболаг (SE)
Астра Актиеболаг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9300030A external-priority patent/SE9300030D0/xx
Priority claimed from SE9300082A external-priority patent/SE9300082D0/xx
Application filed by Астра Актиеболаг (SE), Астра Актиеболаг filed Critical Астра Актиеболаг (SE)
Publication of RU95115547A publication Critical patent/RU95115547A/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Описываются новые соединения, являющиеся глюкокортикостероидами (ГКС), химически связанными с сахарами и соответствующие общей формуле ГКС-О-Сахар, предназначенные для доставки специфичных к ободочной кишке или подвздошной кишке ГКС, к воспаленной слизистой кишечника. Описываются также способы получения этих соединений, фармацевтические препараты, содержащие эти соединения, и использование указанных соединений в медицине.

Claims (1)

  1. Описываются новые соединения, являющиеся глюкокортикостероидами (ГКС), химически связанными с сахарами и соответствующие общей формуле ГКС1-О-Сахар1, предназначенные для доставки специфичных к ободочной кишке или подвздошной кишке ГКС, к воспаленной слизистой кишечника. Описываются также способы получения этих соединений, фармацевтические препараты, содержащие эти соединения, и использование указанных соединений в медицине.
RU95115547/04A 1993-01-08 1993-12-17 Стероидные соединения, способы их получения и фармацевтический препарат RU95115547A (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE9300030-5 1993-01-08
SE9300030A SE9300030D0 (sv) 1993-01-08 1993-01-08 Novel colon- or ileum-specific steroid derivatives
SE9300082A SE9300082D0 (sv) 1993-01-14 1993-01-14 Novel colon- or ileum-specific steroid derivatives
SE9300082-6 1993-01-14

Publications (1)

Publication Number Publication Date
RU95115547A true RU95115547A (ru) 1997-06-10

Family

ID=26661623

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95115547/04A RU95115547A (ru) 1993-01-08 1993-12-17 Стероидные соединения, способы их получения и фармацевтический препарат

Country Status (22)

Country Link
US (2) US5908833A (ru)
EP (1) EP0678097B1 (ru)
JP (1) JP3366640B2 (ru)
KR (1) KR960700266A (ru)
AT (1) ATE183192T1 (ru)
BR (1) BR9307746A (ru)
CA (1) CA2152374A1 (ru)
CZ (1) CZ171095A3 (ru)
DK (1) DK0678097T3 (ru)
ES (1) ES2137353T3 (ru)
FI (1) FI953358A0 (ru)
GR (1) GR3031789T3 (ru)
HU (1) HU221584B (ru)
IS (1) IS4111A (ru)
LV (1) LV10961B (ru)
NO (1) NO305367B1 (ru)
NZ (1) NZ259596A (ru)
PL (1) PL178307B1 (ru)
RU (1) RU95115547A (ru)
SK (1) SK87295A3 (ru)
TW (1) TW261615B (ru)
WO (1) WO1994015947A1 (ru)

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CZ171095A3 (en) * 1993-01-08 1996-01-17 Astra Ab Novel steroidal derivatives specific for colon or ilium
EP0721956B1 (en) * 1993-09-29 2000-08-02 Nissin Shokuhin Kabushiki Kaisha 21-substituted steroid compound
US6028190A (en) 1994-02-01 2000-02-22 The Regents Of The University Of California Probes labeled with energy transfer coupled dyes
US6166024A (en) 1995-03-30 2000-12-26 Mayo Foundation For Medical Education And Research Use of topical azathioprine and thioguanine to treat colorectal adenomas
JP4610734B2 (ja) * 1998-03-19 2011-01-12 三笠製薬株式会社 ２１−置換グリコシルステロイド化合物
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
CN1250563C (zh) 1999-05-04 2006-04-12 斯特拉坎有限公司 雄激素糖苷及其产生雄性征的活性
US8895064B2 (en) 1999-06-14 2014-11-25 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
JP4790950B2 (ja) 1999-06-14 2011-10-12 コスモ・テクノロジーズ・リミテッド 制御放出および味感遮蔽経口医薬組成物
WO2001051057A2 (en) * 2000-01-14 2001-07-19 Strakan Limited Glycosides and orthoester glycosides of glucocorticoids and uses thereof
SE0101220D0 (sv) * 2001-04-04 2001-04-04 Astrazeneca Ab New use
ES2315600T3 (es) * 2004-08-09 2009-04-01 Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts Conjugados de albumina que contienen un ligador glucuronico.
US20080200441A1 (en) * 2007-02-14 2008-08-21 University Of Southern California Estrogen receptor modulators associated pharmaceutical compositions and methods of use
US10154964B2 (en) 2011-09-07 2018-12-18 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
AU2017359043B2 (en) 2016-11-08 2022-06-16 Regeneron Pharmaceuticals, Inc. Steroids and protein-conjugates thereof
WO2018177381A1 (zh) * 2017-03-30 2018-10-04 合肥合源药业有限公司 乳果糖糖苷化合物、其制备方法及其用途
JP7364471B2 (ja) 2017-05-18 2023-10-18 レゲネロン ファーマシューティカルス，インコーポレーテッド シクロデキストリンタンパク質薬物コンジュゲート
SG11202006510XA (en) * 2018-01-08 2020-08-28 Regeneron Pharma Steroids and antibody-conjugates thereof
SG11202010909RA (en) 2018-05-09 2020-12-30 Regeneron Pharma Anti-msr1 antibodies and methods of use thereof

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US3992534A (en) * 1972-05-19 1976-11-16 Ab Bofors Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
SE378109B (ru) * 1972-05-19 1975-08-18 Bofors Ab
US3938233A (en) * 1974-08-12 1976-02-17 Cannon Robert B Heat transfer apparatus
BG33738A3 (en) * 1978-01-25 1983-04-15 Schering Ag,De Method for obtaining of substituated in 17- th position steroids from pregnan row
DE2803660A1 (de) * 1978-01-25 1979-07-26 Schering Ag Neue in 17-position substituierte steroide der pregnanreihe, ihre herstellung und verwendung
US4221787A (en) * 1978-03-28 1980-09-09 Interx Research Corporation Esteramide prodrugs of anti-inflammatory corticosteroids
SE8008524L (sv) * 1980-12-04 1982-06-05 Draco Ab 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
US4456602A (en) * 1982-08-23 1984-06-26 The Upjohn Company Amine containing ester prodrugs of corticosteroids
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CZ171095A3 (en) * 1993-01-08 1996-01-17 Astra Ab Novel steroidal derivatives specific for colon or ilium

Also Published As

Publication number Publication date
WO1994015947A1 (en) 1994-07-21
PL178307B1 (pl) 2000-04-28
EP0678097B1 (en) 1999-08-11
TW261615B (ru) 1995-11-01
HU221584B (hu) 2002-11-28
AU678803B2 (en) 1997-06-12
AU5844794A (en) 1994-08-15
DK0678097T3 (da) 2000-02-07
JPH08505616A (ja) 1996-06-18
ATE183192T1 (de) 1999-08-15
PL309777A1 (en) 1995-11-13
CA2152374A1 (en) 1994-07-21
GR3031789T3 (en) 2000-02-29
US5908833A (en) 1999-06-01
HUT73227A (en) 1996-07-29
NO952683D0 (no) 1995-07-06
JP3366640B2 (ja) 2003-01-14
EP0678097A1 (en) 1995-10-25
US6140308A (en) 2000-10-31
IS4111A (is) 1994-07-09
CZ171095A3 (en) 1996-01-17
FI953358A (fi) 1995-07-07
NO952683L (no) 1995-07-06
NO305367B1 (no) 1999-05-18
HU9502087D0 (en) 1995-09-28
SK87295A3 (en) 1996-04-03
LV10961B (en) 1996-08-20
KR960700266A (ko) 1996-01-19
FI953358A0 (fi) 1995-07-07
LV10961A (lv) 1995-12-20
BR9307746A (pt) 1995-11-14
ES2137353T3 (es) 1999-12-16
NZ259596A (en) 1997-04-24

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