BRPI0413051A - compostos de indazol 3,5-dissubstituìdos, composições farmacêuticas e métodos para mediar ou inibir a proliferação celular - Google Patents

compostos de indazol 3,5-dissubstituìdos, composições farmacêuticas e métodos para mediar ou inibir a proliferação celular

Info

Publication number
BRPI0413051A
BRPI0413051A BRPI0413051-0A BRPI0413051A BRPI0413051A BR PI0413051 A BRPI0413051 A BR PI0413051A BR PI0413051 A BRPI0413051 A BR PI0413051A BR PI0413051 A BRPI0413051 A BR PI0413051A
Authority
BR
Brazil
Prior art keywords
cell proliferation
compounds
pharmaceutical compositions
methods
mediating
Prior art date
Application number
BRPI0413051-0A
Other languages
English (en)
Inventor
Susan Elizabeth Kephart
Indrawan James Mcalpine
Siegfried Heinz Reich
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BRPI0413051A publication Critical patent/BRPI0413051A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"COMPOSTOS DE INDAZOL 3,5-DISSUBSTITUìDOS, COMPOSIçõES FARMACêUTICAS E MéTODOS PARA MEDIAR OU INIBIR A PROLIFERAçãO CELULAR". São descritos compostos de indazol 3,5-dissubstituídos que modulam e/ou inibem a proliferação celular, tal como a atividade de proteínas cinases. Estes compostos e as composições farmacêuticas que os contêm são capazes de mediar doenças dependentes de CDK para modular e/ou inibir proliferação celular indesejada. A invenção é também direcionada para a utilização terapêutica ou profilática de composições farmacêuticas contendo tais compostos, e para métodos de tratamento de câncer bem como outros estados patológicos associados à angiogênese e/ou proliferação celular indesejada, tais como retinopatia diabética, glaucoma neovascular, artrite reumatóide e psoríase, através da administração de quantidades eficazes de tais compostos.
BRPI0413051-0A 2003-07-30 2004-07-19 compostos de indazol 3,5-dissubstituìdos, composições farmacêuticas e métodos para mediar ou inibir a proliferação celular BRPI0413051A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49147403P 2003-07-30 2003-07-30
US49207303P 2003-07-31 2003-07-31
PCT/IB2004/002441 WO2005009997A1 (en) 2003-07-30 2004-07-19 3,5 disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation

Publications (1)

Publication Number Publication Date
BRPI0413051A true BRPI0413051A (pt) 2006-10-17

Family

ID=34108010

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413051-0A BRPI0413051A (pt) 2003-07-30 2004-07-19 compostos de indazol 3,5-dissubstituìdos, composições farmacêuticas e métodos para mediar ou inibir a proliferação celular

Country Status (24)

Country Link
US (2) US7008953B2 (pt)
EP (1) EP1658284A1 (pt)
JP (1) JP3920914B2 (pt)
KR (1) KR20060030914A (pt)
AR (1) AR045143A1 (pt)
AU (1) AU2004259531A1 (pt)
BR (1) BRPI0413051A (pt)
CA (1) CA2532908A1 (pt)
CO (1) CO5650247A2 (pt)
EA (1) EA200600123A1 (pt)
EC (1) ECSP066335A (pt)
IL (1) IL172924A0 (pt)
IS (1) IS8214A (pt)
MA (1) MA27937A1 (pt)
MX (1) MXPA06001193A (pt)
NL (1) NL1026761C2 (pt)
NO (1) NO20060319L (pt)
OA (1) OA13196A (pt)
PA (1) PA8608201A1 (pt)
PE (1) PE20050330A1 (pt)
TN (1) TNSN06038A1 (pt)
TW (1) TW200521124A (pt)
UY (1) UY28442A1 (pt)
WO (1) WO2005009997A1 (pt)

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US7008953B2 (en) 2006-03-07
JP3920914B2 (ja) 2007-05-30
IS8214A (is) 2005-12-30
WO2005009997A1 (en) 2005-02-03
AU2004259531A1 (en) 2005-02-03
EA200600123A1 (ru) 2006-06-30
US20060142345A1 (en) 2006-06-29
EP1658284A1 (en) 2006-05-24
TW200521124A (en) 2005-07-01
CO5650247A2 (es) 2006-06-30
AR045143A1 (es) 2005-10-19
CA2532908A1 (en) 2005-02-03
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IL172924A0 (en) 2006-06-11
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