EA200600123A1 - 3,5-дизамещённые индазольные соединения, фармацевтические композиции и способы опосредования или ингибирования клеточной пролиферации - Google Patents

3,5-дизамещённые индазольные соединения, фармацевтические композиции и способы опосредования или ингибирования клеточной пролиферации

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Publication number
EA200600123A1
EA200600123A1 EA200600123A EA200600123A EA200600123A1 EA 200600123 A1 EA200600123 A1 EA 200600123A1 EA 200600123 A EA200600123 A EA 200600123A EA 200600123 A EA200600123 A EA 200600123A EA 200600123 A1 EA200600123 A1 EA 200600123A1
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EA
Eurasian Patent Office
Prior art keywords
compounds
pharmaceutical compositions
methods
cell proliferation
indose
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EA200600123A
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English (en)
Inventor
Сьюзн Элизабет Кипхарт
Индраван Джеймс Макалпайн
Зигфрид Хайнц Райх
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Пфайзер Инк.
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Publication of EA200600123A1 publication Critical patent/EA200600123A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Описываются 3,5-дизамещенные индазольные соединения, которые модулируют и/или ингибируют клеточную пролиферацию, такую как активность протеинкиназ. Данные соединения и фармацевтические композиции, содержащие их, способны опосредовать CDK-зависимые заболевания для модулирования и/или ингибирования нежелательной клеточной пролиферации. Изобретение также направлено на терапевтическое или профилактическое использование фармацевтических композиций, содержащих такие соединения, и на способы лечения рака, а также других болезненных состояний, связанных с ненужным ангиогенезом и/или клеточной пролиферацией, таких как диабетическая ретинопатия, неоваскулярная глаукома, ревматоидный артрит и псориаз, путем введения эффективных количеств таких соединений.
EA200600123A 2003-07-30 2004-07-19 3,5-дизамещённые индазольные соединения, фармацевтические композиции и способы опосредования или ингибирования клеточной пролиферации EA200600123A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49147403P 2003-07-30 2003-07-30
US49207303P 2003-07-31 2003-07-31
PCT/IB2004/002441 WO2005009997A1 (en) 2003-07-30 2004-07-19 3,5 disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation

Publications (1)

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EA200600123A1 true EA200600123A1 (ru) 2006-06-30

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EA200600123A EA200600123A1 (ru) 2003-07-30 2004-07-19 3,5-дизамещённые индазольные соединения, фармацевтические композиции и способы опосредования или ингибирования клеточной пролиферации

Country Status (24)

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US (2) US7008953B2 (ru)
EP (1) EP1658284A1 (ru)
JP (1) JP3920914B2 (ru)
KR (1) KR20060030914A (ru)
AR (1) AR045143A1 (ru)
AU (1) AU2004259531A1 (ru)
BR (1) BRPI0413051A (ru)
CA (1) CA2532908A1 (ru)
CO (1) CO5650247A2 (ru)
EA (1) EA200600123A1 (ru)
EC (1) ECSP066335A (ru)
IL (1) IL172924A0 (ru)
IS (1) IS8214A (ru)
MA (1) MA27937A1 (ru)
MX (1) MXPA06001193A (ru)
NL (1) NL1026761C2 (ru)
NO (1) NO20060319L (ru)
OA (1) OA13196A (ru)
PA (1) PA8608201A1 (ru)
PE (1) PE20050330A1 (ru)
TN (1) TNSN06038A1 (ru)
TW (1) TW200521124A (ru)
UY (1) UY28442A1 (ru)
WO (1) WO2005009997A1 (ru)

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IL172924A0 (en) 2006-06-11
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OA13196A (en) 2006-12-13
US20060142345A1 (en) 2006-06-29
ECSP066335A (es) 2006-07-28
CA2532908A1 (en) 2005-02-03
KR20060030914A (ko) 2006-04-11
US20050026960A1 (en) 2005-02-03
MA27937A1 (fr) 2006-06-01
UY28442A1 (es) 2005-02-28
EP1658284A1 (en) 2006-05-24
IS8214A (is) 2005-12-30
NL1026761A1 (nl) 2005-02-01
AU2004259531A1 (en) 2005-02-03
TW200521124A (en) 2005-07-01
JP3920914B2 (ja) 2007-05-30
WO2005009997A1 (en) 2005-02-03
TNSN06038A1 (fr) 2007-10-03
BRPI0413051A (pt) 2006-10-17
JP2007500183A (ja) 2007-01-11
US7008953B2 (en) 2006-03-07
AR045143A1 (es) 2005-10-19
PA8608201A1 (es) 2005-03-03
CO5650247A2 (es) 2006-06-30
PE20050330A1 (es) 2005-05-16
NO20060319L (no) 2006-02-24

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