AR045143A1 - Compuestos de indazol 3,5- distribuidos, composiciones farmaceuticas y metodos para intervenir en o inhibir la proliferacion celular - Google Patents

Compuestos de indazol 3,5- distribuidos, composiciones farmaceuticas y metodos para intervenir en o inhibir la proliferacion celular

Info

Publication number
AR045143A1
AR045143A1 ARP040102681A ARP040102681A AR045143A1 AR 045143 A1 AR045143 A1 AR 045143A1 AR P040102681 A ARP040102681 A AR P040102681A AR P040102681 A ARP040102681 A AR P040102681A AR 045143 A1 AR045143 A1 AR 045143A1
Authority
AR
Argentina
Prior art keywords
cr5r6
cr7r8
cycloalkyl
compounds
cell proliferation
Prior art date
Application number
ARP040102681A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AR045143A1 publication Critical patent/AR045143A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Se describen compuestos de indazol-3,5-disustituidos que modulan y/o inhiben la proliferación celular tal como la actividad de las proteínas cinasa. Estos compuestos y composiciones farmacéuticas que los contienen son capaces de intervenir en enfermedades de la CDK para modular y/o inhibir la proliferación celular no deseada. La presente también se dirige al uso terapéutico o profiláctico de composiciones farmacéuticas que contienen tales compuestos y a métodos para tratar el cáncer así como otras condiciones patológicas asociadas con angiogénesis y/o proliferación celular, no deseada, tales como: retinopatía, diabética, glaucoma neovascular, artritis reumatoide y soriasis, por administración de cantidades eficaces de tales compuestos. Reivindicación 1: Un compuesto o sal farmacéuticamente aceptable o solvato, de la fórmula (1), en la que R1, R2, R3 y R4 se seleccionan del grupo que consta de: H, halo, ciano, nitro, trifluormetoxi, trifluormetilo, azido, hidroxi, alcoxi C1-6, alquilo C1-10, alquenilo C2-6, alquinilo C2-6, -C(O)R5, -C(O)OR5, -OC(O)R5, -NR5C(O)R6, -C(O)NR5R6, -(CR5R6)NR7R8, -CR5R6NR7R8, -NR5OR6, -SO2NR5R6, -S(O)j(alquilo C1-6), en la que j es un número entero de 0 a 2, -(CR5R6)t(arilo C6-10), -(CR5R6)t(cicloalquilo C3-10), -C(CR5R6)t(grupo heterocíclico de 4-10 miembros), -(CR5R6)qC(O)(CR7R8)t(arilo C6-10), -(CR5R6)tC(O)(CR7R8)t(cicloalquilo C3-10), -(CR5R6)qC(O)(CR7R8)t(grupo heterocíclico de 4-10 miembros), -(CR5R6)tO(CR7R8)q(arilo C6-10), -(CR5R6)tO(CR7R8)q(cicloalquilo C3-10), -(CR5R6)tO(CR7R8)q(grupo heterocíclico de 4-10 miembros), -(CR5R6)qSO2(CR7R8)t(arilo C6-10), -(CR5R6)qSO2(CR7R8)t(cicloalquilo C3-10) y -(CR5R6)qSO2(CR7R8)t(grupo heterocíclico de 4-10 miembros), en los que q y t son cada uno independientemente un número entero de 0 a 5; 1 ó 2 átomos de carbono del anillo de los restos cicloalquilo o heterocíclico de los grupos R1, R2, R3 o R4 anteriores están opcionalmente sustituidos con un resto (=O) oxo, cada R5, R6, R7 y R8 se selecciona independientemente de: H, alquilo C1-6; y, en la que R1, R2, R3 y R4 no son H al mismos tiempo.
ARP040102681A 2003-07-30 2004-07-28 Compuestos de indazol 3,5- distribuidos, composiciones farmaceuticas y metodos para intervenir en o inhibir la proliferacion celular AR045143A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49147403P 2003-07-30 2003-07-30
US49207303P 2003-07-31 2003-07-31

Publications (1)

Publication Number Publication Date
AR045143A1 true AR045143A1 (es) 2005-10-19

Family

ID=34108010

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040102681A AR045143A1 (es) 2003-07-30 2004-07-28 Compuestos de indazol 3,5- distribuidos, composiciones farmaceuticas y metodos para intervenir en o inhibir la proliferacion celular

Country Status (24)

Country Link
US (2) US7008953B2 (es)
EP (1) EP1658284A1 (es)
JP (1) JP3920914B2 (es)
KR (1) KR20060030914A (es)
AR (1) AR045143A1 (es)
AU (1) AU2004259531A1 (es)
BR (1) BRPI0413051A (es)
CA (1) CA2532908A1 (es)
CO (1) CO5650247A2 (es)
EA (1) EA200600123A1 (es)
EC (1) ECSP066335A (es)
IL (1) IL172924A0 (es)
IS (1) IS8214A (es)
MA (1) MA27937A1 (es)
MX (1) MXPA06001193A (es)
NL (1) NL1026761C2 (es)
NO (1) NO20060319L (es)
OA (1) OA13196A (es)
PA (1) PA8608201A1 (es)
PE (1) PE20050330A1 (es)
TN (1) TNSN06038A1 (es)
TW (1) TW200521124A (es)
UY (1) UY28442A1 (es)
WO (1) WO2005009997A1 (es)

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