ATE231559T1 - Expressionsnachweis durch hybridisierung an oligonukleotidarrays hoher belegungsdichte - Google Patents

Expressionsnachweis durch hybridisierung an oligonukleotidarrays hoher belegungsdichte

Info

Publication number
ATE231559T1
ATE231559T1 AT96931598T AT96931598T ATE231559T1 AT E231559 T1 ATE231559 T1 AT E231559T1 AT 96931598 T AT96931598 T AT 96931598T AT 96931598 T AT96931598 T AT 96931598T AT E231559 T1 ATE231559 T1 AT E231559T1
Authority
AT
Austria
Prior art keywords
nucleic acids
array
rna transcripts
oligonucleotide probes
hybridization
Prior art date
Application number
AT96931598T
Other languages
German (de)
English (en)
Inventor
David J Lockhart
Eugene L Brown
Gordon Wong
Mark Chee
Thomas R Gingeras
Michael P Mittmann
Robert J Lipshutz
Stephen P A Fodor
Chunwei Wang
Original Assignee
Affymetrix Inc A Delaware Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24108589&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE231559(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Affymetrix Inc A Delaware Corp filed Critical Affymetrix Inc A Delaware Corp
Application granted granted Critical
Publication of ATE231559T1 publication Critical patent/ATE231559T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT96931598T 1995-09-15 1996-09-13 Expressionsnachweis durch hybridisierung an oligonukleotidarrays hoher belegungsdichte ATE231559T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/529,115 US6040138A (en) 1995-09-15 1995-09-15 Expression monitoring by hybridization to high density oligonucleotide arrays
PCT/US1996/014839 WO1997010365A1 (en) 1995-09-15 1996-09-13 Expression monitoring by hybridization to high density oligonucleotide arrays

Publications (1)

Publication Number Publication Date
ATE231559T1 true ATE231559T1 (de) 2003-02-15

Family

ID=24108589

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96931598T ATE231559T1 (de) 1995-09-15 1996-09-13 Expressionsnachweis durch hybridisierung an oligonukleotidarrays hoher belegungsdichte

Country Status (8)

Country Link
US (6) US6040138A (enExample)
EP (1) EP0853679B1 (enExample)
JP (1) JPH11512293A (enExample)
AT (1) ATE231559T1 (enExample)
AU (1) AU7073496A (enExample)
CA (1) CA2232047A1 (enExample)
DE (1) DE69625920T2 (enExample)
WO (1) WO1997010365A1 (enExample)

Families Citing this family (926)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5547839A (en) * 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US6040138A (en) * 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6919211B1 (en) 1989-06-07 2005-07-19 Affymetrix, Inc. Polypeptide arrays
US6955915B2 (en) 1989-06-07 2005-10-18 Affymetrix, Inc. Apparatus comprising polymers
US6589726B1 (en) 1991-09-04 2003-07-08 Metrigen, Inc. Method and apparatus for in situ synthesis on a solid support
US6849462B1 (en) 1991-11-22 2005-02-01 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US6943034B1 (en) 1991-11-22 2005-09-13 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US20030134291A1 (en) * 1993-06-25 2003-07-17 Affymetrix, Inc. Polymorphism detection
US7378236B1 (en) 1994-06-17 2008-05-27 The Board Of Trustees Of The Leland Stanford Junior University Method for analyzing gene expression patterns
US7323298B1 (en) 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US6379897B1 (en) * 2000-11-09 2002-04-30 Nanogen, Inc. Methods for gene expression monitoring on electronic microarrays
US20030220748A1 (en) * 1994-10-21 2003-11-27 Affymetrix, Inc., A California Corporation Computer-aided techniques for analyzing biological sequences
US6600996B2 (en) * 1994-10-21 2003-07-29 Affymetrix, Inc. Computer-aided techniques for analyzing biological sequences
US8236493B2 (en) * 1994-10-21 2012-08-07 Affymetrix, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US6720140B1 (en) * 1995-06-07 2004-04-13 Invitrogen Corporation Recombinational cloning using engineered recombination sites
US6143557A (en) 1995-06-07 2000-11-07 Life Technologies, Inc. Recombination cloning using engineered recombination sites
US20050136420A1 (en) * 2000-05-19 2005-06-23 Affymetrix, Inc. Methods and computer software products for identifying transcribed regions of a genome
US20040180364A1 (en) * 2003-01-08 2004-09-16 Affymetrix, Inc. Methods for analyzing global regulation of coding and non-coding RNA transcripts involving low molecular weight RNAs
US6953663B1 (en) 1995-11-29 2005-10-11 Affymetrix, Inc. Polymorphism detection
US6300063B1 (en) 1995-11-29 2001-10-09 Affymetrix, Inc. Polymorphism detection
EP0880598A4 (en) 1996-01-23 2005-02-23 Affymetrix Inc RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM
US7423143B2 (en) 1996-01-23 2008-09-09 Affymetrix. Inc. Nucleic acid labeling compounds
US7291463B2 (en) 1996-01-23 2007-11-06 Affymetrix, Inc. Nucleic acid labeling compounds
US7468243B2 (en) 2001-03-12 2008-12-23 Affymetrix, Inc. 2-aminopyrimidin-4-one nucleic acid labeling compounds
US7282327B2 (en) 1996-01-23 2007-10-16 Affymetrix, Inc. Nucleic acid labeling compounds
US6864059B2 (en) 1996-01-23 2005-03-08 Affymetrix, Inc. Biotin containing C-glycoside nucleic acid labeling compounds
US6965020B2 (en) 1996-01-23 2005-11-15 Affymetrix, Inc. Nucleic acid labeling compounds
US20010018514A1 (en) 1998-07-31 2001-08-30 Mcgall Glenn H. Nucleic acid labeling compounds
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US6881571B1 (en) 1998-03-11 2005-04-19 Exonhit Therapeutics S.A. Qualitative differential screening
US6013440A (en) 1996-03-11 2000-01-11 Affymetrix, Inc. Nucleic acid affinity columns
JP4468488B2 (ja) 1996-05-29 2010-05-26 コーネル・リサーチ・ファンデーション・インコーポレイテッド 組み合せたリガーゼ検出およびポリメラーゼ連鎖反応を用いる核酸配列相違の検出
US6391550B1 (en) * 1996-09-19 2002-05-21 Affymetrix, Inc. Identification of molecular sequence signatures and methods involving the same
AU4495497A (en) 1996-09-19 1998-04-14 Affymetrix, Inc. Identification of molecular sequence signatures and methods involving the same
DE69737327T2 (de) * 1996-11-06 2007-11-08 Smithkline Beecham Corp. Verfahren zur identifizierung von essentiellen genen für das wachstum eines organismus
US6887665B2 (en) * 1996-11-14 2005-05-03 Affymetrix, Inc. Methods of array synthesis
EP0946286B1 (en) * 1996-11-14 2003-03-19 Affymetrix, Inc. Chemical amplification for the synthesis of patterned arrays
AU6646398A (en) 1996-12-31 1998-07-31 Genometrix Incorporated Multiplexed molecular analysis apparatus and method
US6165709A (en) 1997-02-28 2000-12-26 Fred Hutchinson Cancer Research Center Methods for drug target screening
NO972006D0 (no) 1997-04-30 1997-04-30 Forskningsparken I Aas As Ny metode for diagnose av sykdommer
US5885803A (en) * 1997-06-19 1999-03-23 Incyte Pharmaceuticals, Inc. Disease associated protein kinases
NZ516848A (en) 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
DE69823206T2 (de) 1997-07-25 2004-08-19 Affymetrix, Inc. (a Delaware Corp.), Santa Clara Verfahren zur herstellung einer bio-informatik-datenbank
US6420108B2 (en) * 1998-02-09 2002-07-16 Affymetrix, Inc. Computer-aided display for comparative gene expression
US6826296B2 (en) 1997-07-25 2004-11-30 Affymetrix, Inc. Method and system for providing a probe array chip design database
US7068830B2 (en) * 1997-07-25 2006-06-27 Affymetrix, Inc. Method and system for providing a probe array chip design database
US6326489B1 (en) 1997-08-05 2001-12-04 Howard Hughes Medical Institute Surface-bound, bimolecular, double-stranded DNA arrays
US6511803B1 (en) 1997-10-10 2003-01-28 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
AU8826598A (en) 1997-10-10 1999-05-03 President And Fellows Of Harvard College Surface-bound, double-stranded dna protein arrays
JP2001519538A (ja) 1997-10-10 2001-10-23 プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ 核酸アレイのレプリカ増幅
US6485944B1 (en) 1997-10-10 2002-11-26 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
CA2307016A1 (en) * 1997-10-24 1999-05-06 Life Technologies, Inc. Recombinational cloning using nucleic acids having recombination sites
US7351578B2 (en) 1999-12-10 2008-04-01 Invitrogen Corp. Use of multiple recombination sites with unique specificity in recombinational cloning
US20030124555A1 (en) * 2001-05-21 2003-07-03 Invitrogen Corporation Compositions and methods for use in isolation of nucleic acid molecules
CN101125873A (zh) * 1997-10-24 2008-02-20 茵维特罗根公司 利用具重组位点的核酸进行重组克隆
ATE537270T1 (de) * 1997-10-30 2011-12-15 Cold Spring Harbor Lab Sondenanordnungen und deren verwendungen für verfahren zur dns-unterscheidung
EP1040204B1 (en) 1997-12-19 2004-03-03 Affymetrix, Inc. Exploiting genomics in the search for new drugs
US20030096232A1 (en) 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
US6238869B1 (en) 1997-12-19 2001-05-29 High Throughput Genomics, Inc. High throughput assay system
EP1418244A1 (en) * 1997-12-19 2004-05-12 Affymetrix, Inc. Exploiting genomics in the search for new drugs
US6232066B1 (en) 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
US6087102A (en) 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
US6289229B1 (en) 1998-01-20 2001-09-11 Scimed Life Systems, Inc. Readable probe array for in vivo use
KR20010040420A (ko) * 1998-01-26 2001-05-15 에바-마리아 시마-메이어, 얼설라 멜져, 마거, 하르트만 화합물 스크리닝을 위한 유전자 발현 방법
JP2002502977A (ja) * 1998-02-04 2002-01-29 インビトロジェン コーポレイション マイクロアレイとその使用
US6187535B1 (en) 1998-02-18 2001-02-13 Institut Pasteur Fast and exhaustive method for selecting a prey polypeptide interacting with a bait polypeptide of interest: application to the construction of maps of interactors polypeptides
EP1717249A1 (en) 1998-03-12 2006-11-02 Georgetown University Peptides containing a cholesterol recognition sequence and their uses
CA2322843A1 (en) * 1998-03-27 1999-09-30 The Board Of Trustees Of The Leland Stanford, Jr. University Hypoxia-inducible human genes, proteins, and uses thereof
US6218114B1 (en) * 1998-03-27 2001-04-17 Academia Sinica Methods for detecting differentially expressed genes
JP2002509706A (ja) 1998-03-31 2002-04-02 ジンザイム コーポレイション 肺癌の診断及び治療方法
US6979728B2 (en) * 1998-05-04 2005-12-27 Baylor College Of Medicine Articles of manufacture and methods for array based analysis of biological molecules
US5965352A (en) 1998-05-08 1999-10-12 Rosetta Inpharmatics, Inc. Methods for identifying pathways of drug action
US6132969A (en) * 1998-06-19 2000-10-17 Rosetta Inpharmatics, Inc. Methods for testing biological network models
US6218122B1 (en) * 1998-06-19 2001-04-17 Rosetta Inpharmatics, Inc. Methods of monitoring disease states and therapies using gene expression profiles
AU4991199A (en) * 1998-07-15 2000-02-07 Chiron Corporation Methods and compositions for comparing and normalizing assays
US6306643B1 (en) * 1998-08-24 2001-10-23 Affymetrix, Inc. Methods of using an array of pooled probes in genetic analysis
US20040199544A1 (en) * 2000-11-02 2004-10-07 Affymetrix, Inc. Method and apparatus for providing an expression data mining database
US6185561B1 (en) 1998-09-17 2001-02-06 Affymetrix, Inc. Method and apparatus for providing and expression data mining database
CA2348003A1 (en) * 1998-09-23 2000-04-20 Cleveland Clinic Foundation Novel interferon stimulated and repressed genes
US6203989B1 (en) 1998-09-30 2001-03-20 Affymetrix, Inc. Methods and compositions for amplifying detectable signals in specific binding assays
US6262216B1 (en) 1998-10-13 2001-07-17 Affymetrix, Inc. Functionalized silicon compounds and methods for their synthesis and use
US6489096B1 (en) 1998-10-15 2002-12-03 Princeton University Quantitative analysis of hybridization patterns and intensities in oligonucleotide arrays
US6950752B1 (en) 1998-10-27 2005-09-27 Rosetta Inpharmatics Llc Methods for removing artifact from biological profiles
US6203987B1 (en) 1998-10-27 2001-03-20 Rosetta Inpharmatics, Inc. Methods for using co-regulated genesets to enhance detection and classification of gene expression patterns
US6468476B1 (en) 1998-10-27 2002-10-22 Rosetta Inpharmatics, Inc. Methods for using-co-regulated genesets to enhance detection and classification of gene expression patterns
US6453241B1 (en) 1998-12-23 2002-09-17 Rosetta Inpharmatics, Inc. Method and system for analyzing biological response signal data
DE69942314D1 (de) * 1998-12-23 2010-06-10 Medsaic Pty Ltd Versuchsanordnung zum nachweis von bindungspartnern
US6801859B1 (en) 1998-12-23 2004-10-05 Rosetta Inpharmatics Llc Methods of characterizing drug activities using consensus profiles
US6370478B1 (en) 1998-12-28 2002-04-09 Rosetta Inpharmatics, Inc. Methods for drug interaction prediction using biological response profiles
US6222093B1 (en) 1998-12-28 2001-04-24 Rosetta Inpharmatics, Inc. Methods for determining therapeutic index from gene expression profiles
US6251601B1 (en) * 1999-02-02 2001-06-26 Vysis, Inc. Simultaneous measurement of gene expression and genomic abnormalities using nucleic acid microarrays
EP2336148A1 (en) * 1999-03-02 2011-06-22 Life Technologies Corporation Compositions and methods for use in recombinational cloning of nucleic acids
US7005256B1 (en) * 1999-03-10 2006-02-28 Cold Spring Harbor Laboratory Gene chip technology for determining memory genes
WO2000053811A1 (en) * 1999-03-11 2000-09-14 Orion Genomics, Llc Genome chips and optical transcript mapping
AU3747400A (en) * 1999-03-15 2000-10-04 Vistagen, Inc. Bar coding and indentifying nucleic acids using a limited number of probes and low stringency conditions
EP1041385A3 (en) * 1999-03-30 2004-01-02 Fuji Photo Film Co., Ltd. Method and apparatus for detecting an organism-originated substance
US6824866B1 (en) 1999-04-08 2004-11-30 Affymetrix, Inc. Porous silica substrates for polymer synthesis and assays
WO2000065095A2 (en) * 1999-04-23 2000-11-02 Clontech Laboratories, Inc. Methods and compositions for performing array based hybridization assays
JP3957118B2 (ja) * 1999-05-18 2007-08-15 富士フイルム株式会社 試験片およびこの試験片からの画像情報読取装置
DE20023342U1 (de) † 1999-05-19 2003-10-16 Eppendorf Array Technologies, Namur Vorrichtung und Kit zur Identifizierung und/oder Quantifizierung einer Zielverbindung auf Chips
WO2000072018A1 (en) 1999-05-19 2000-11-30 Advanced Array Technologies S.A. Method for the identification and/or the quantification of a target compound
US6221597B1 (en) 1999-05-21 2001-04-24 Rosetta Inpharmatics, Inc. Essential genes of yeast as targets for antifungal agents, herbicides, insecticides and anti-proliferative drugs
US6197517B1 (en) 1999-05-21 2001-03-06 Rosetta Inpharmatics, Inc. Essential genes of yeast as targets for antifungal agents, herbicides, insecticides and anti-proliferative drugs
US6200803B1 (en) 1999-05-21 2001-03-13 Rosetta Inpharmatics, Inc. Essential genes of yeast as targets for antifungal agents, herbicides, insecticides and anti-proliferative drugs
US6713255B1 (en) * 1999-06-07 2004-03-30 Fuji Photo Film Co., Ltd. DNA chip, PNA chip, and their preparation methods
US6716579B1 (en) 1999-06-11 2004-04-06 Narayan Baidya Gene specific arrays, preparation and use
CA2375220A1 (en) * 1999-06-11 2000-12-21 Narayan Baidya Gene specific arrays and the use thereof
US6656682B1 (en) 1999-06-21 2003-12-02 Nisshinbo Industries, Inc. Nucleic acid-immobilized substrate
EP1208126B1 (en) 1999-07-02 2006-04-12 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface or substrate, where the polymers have water-soluble or water-dispersible segments and probes bonded thereto
US6461816B1 (en) * 1999-07-09 2002-10-08 Agilent Technologies, Inc. Methods for controlling cross-hybridization in analysis of nucleic acid sequences
US6346423B1 (en) 1999-07-16 2002-02-12 Agilent Technologies, Inc. Methods and compositions for producing biopolymeric arrays
US7209836B1 (en) * 1999-07-16 2007-04-24 Perkinelmer Las, Inc. Method and system for automatically creating crosstalk-corrected data of a microarray
US7013221B1 (en) * 1999-07-16 2006-03-14 Rosetta Inpharmatics Llc Iterative probe design and detailed expression profiling with flexible in-situ synthesis arrays
WO2001006013A1 (en) * 1999-07-16 2001-01-25 Rosetta Inpharmatics, Inc. Methods for determining the specificity and sensitivity of oligonucleotides for hybridization
US7371516B1 (en) 1999-07-16 2008-05-13 Rosetta Inpharmatics Llc Methods for determining the specificity and sensitivity of oligonucleo tides for hybridization
US6713309B1 (en) 1999-07-30 2004-03-30 Large Scale Proteomics Corporation Microarrays and their manufacture
US6864050B2 (en) 1999-07-30 2005-03-08 Affymetrix, Inc. Single-phase amplification of nucleic acids
US7179638B2 (en) 1999-07-30 2007-02-20 Large Scale Biology Corporation Microarrays and their manufacture by slicing
US6420105B1 (en) * 1999-08-13 2002-07-16 University Of Kentucky Research Foundation Method for analyzing molecular expression or function in an intact single cell
US7062076B1 (en) * 1999-08-27 2006-06-13 Iris Biotechnologies, Inc. Artificial intelligence system for genetic analysis
AU785341B2 (en) 1999-08-27 2007-01-25 Iris Biotechnologies Inc. Artificial intelligence system for genetic analysis
JP2003508763A (ja) * 1999-08-27 2003-03-04 マトリックス テクノロジーズ コーポレイション 固体支持体上にリガンドを固定化する方法及び装置並びにその使用方法
WO2001018524A2 (en) 1999-08-30 2001-03-15 Illumina, Inc. Methods for improving signal detection from an array
US6358557B1 (en) * 1999-09-10 2002-03-19 Sts Biopolymers, Inc. Graft polymerization of substrate surfaces
US7244559B2 (en) * 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7211390B2 (en) * 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US6505125B1 (en) * 1999-09-28 2003-01-07 Affymetrix, Inc. Methods and computer software products for multiple probe gene expression analysis
AU7748200A (en) * 1999-09-30 2001-04-30 Varian Associates, Inc. Hypoxia-related human genes, proteins, and uses thereof
US6271002B1 (en) 1999-10-04 2001-08-07 Rosetta Inpharmatics, Inc. RNA amplification method
AU1075701A (en) 1999-10-08 2001-04-23 Protogene Laboratories, Inc. Method and apparatus for performing large numbers of reactions using array assembly
US6607885B1 (en) 1999-10-15 2003-08-19 E. I. Du Pont De Nemours And Company Method for high-density microarray medicated gene expression profiling
WO2001033228A2 (en) * 1999-11-03 2001-05-10 Oncotech, Inc. Cancer diagnosis employing cell-sorting and gene-profiles
US6448013B1 (en) * 1999-11-24 2002-09-10 Incyte Genomics, Inc. Duplex probes for hybridization reactions
JP2001149060A (ja) 1999-11-29 2001-06-05 Nisshinbo Ind Inc 核酸固定化基板
US6274321B1 (en) * 1999-12-03 2001-08-14 The Regents Of The University Of California High throughput functional screening of cDNAs
EP2210948A3 (en) * 1999-12-10 2010-10-06 Life Technologies Corporation Use of multiple recombination sites with unique specificity in recombinational cloning
US6913882B2 (en) 1999-12-22 2005-07-05 Affymetrix, Inc. Methods of screening for B cell activity modulators
US6800439B1 (en) 2000-01-06 2004-10-05 Affymetrix, Inc. Methods for improved array preparation
US20050164290A1 (en) * 2000-01-13 2005-07-28 Affymetrix, Inc. Computer software for sequence selection
GB2397376B (en) * 2000-02-04 2004-12-01 Aeomica Inc Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human heart
US20020081590A1 (en) * 2000-02-04 2002-06-27 Aeomica, Inc. Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence
US20050214825A1 (en) * 2000-02-07 2005-09-29 John Stuelpnagel Multiplex sample analysis on universal arrays
US7582420B2 (en) * 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US8076063B2 (en) * 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US6770441B2 (en) * 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
AU2001241586A1 (en) * 2000-02-17 2001-08-27 Prolx Pharmaceuticals, Lp Dna arrays for determining drug selectivity
US20020111746A1 (en) * 2000-03-15 2002-08-15 Wei-Min Liu Systems and computer software products for gene expression analysis
US6833450B1 (en) 2000-03-17 2004-12-21 Affymetrix, Inc. Phosphite ester oxidation in nucleic acid array preparation
US6806361B1 (en) 2000-03-17 2004-10-19 Affymetrix, Inc. Methods of enhancing functional performance of nucleic acid arrays
US7829313B2 (en) 2000-03-24 2010-11-09 Eppendorf Array Technologies Identification and quantification of a plurality of biological (micro)organisms or their components
US8288128B2 (en) 2004-11-18 2012-10-16 Eppendorf Array Technologies S.A. Real-time quantification of multiple targets on a micro-array
US6884578B2 (en) * 2000-03-31 2005-04-26 Affymetrix, Inc. Genes differentially expressed in secretory versus proliferative endometrium
US7157564B1 (en) 2000-04-06 2007-01-02 Affymetrix, Inc. Tag nucleic acids and probe arrays
US6571005B1 (en) * 2000-04-21 2003-05-27 The Regents Of The University Of California Feature extraction and normalization algorithms for high-density oligonucleotide gene expression array data
JP2003530894A (ja) * 2000-04-25 2003-10-21 アフィメトリックス インコーポレイテッド 選択的にスプライシングされた遺伝子の発現をモニターするための方法
US7363165B2 (en) 2000-05-04 2008-04-22 The Board Of Trustees Of The Leland Stanford Junior University Significance analysis of microarrays
EP1366182A2 (en) * 2000-05-04 2003-12-03 Syngenta Participations AG Assay for nucleic acid analysis
US7682837B2 (en) * 2000-05-05 2010-03-23 Board Of Trustees Of Leland Stanford Junior University Devices and methods to form a randomly ordered array of magnetic beads and uses thereof
US20020120409A1 (en) * 2000-05-19 2002-08-29 Affymetrix, Inc. Methods for gene expression analysis
WO2001090746A1 (en) * 2000-05-19 2001-11-29 Affymetrix, Inc. Methods and computer software products for transcriptional annotation
US7244560B2 (en) * 2000-05-21 2007-07-17 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
DE10025384A1 (de) * 2000-05-24 2002-02-21 Microdiscovery Gmbh Quantitative Messung von Molekülmengen im komplexen Gemischen
US7005259B1 (en) 2000-06-01 2006-02-28 Affymetrix, Inc. Methods for array preparation using substrate rotation
WO2001096866A1 (en) * 2000-06-14 2001-12-20 Vistagen, Inc. Toxicity typing using liver stem cells
US7003403B1 (en) 2000-06-15 2006-02-21 The United States Of America As Represented By The Department Of Health And Human Services Quantifying gene relatedness via nonlinear prediction of gene
US20030064372A1 (en) * 2000-06-22 2003-04-03 Bodnar Jackie S. Gene and sequence variation associated with lipid disorder
CN1498274A (zh) * 2000-06-26 2004-05-19 Ŧب������˾ 基于转录的核酸扩增方法和组合物
US7846733B2 (en) * 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
US20070141434A1 (en) * 2000-06-26 2007-06-21 Joshi Ashok V Sanitizing Device and Associated Method Using Electrochemically Produced Sanitizing Agents
US6706474B1 (en) * 2000-06-27 2004-03-16 Board Of Trustees Of The University Of Illinois Nucleic acid enzyme biosensors for ions
WO2002002804A1 (en) * 2000-06-30 2002-01-10 Aros Applied Biotechnology Aps Gene expression in biological conditions
US6913879B1 (en) * 2000-07-10 2005-07-05 Telechem International Inc. Microarray method of genotyping multiple samples at multiple LOCI
JP2002142765A (ja) * 2000-07-14 2002-05-21 Tosoh Corp 新規ゲノム解析法
US6725230B2 (en) * 2000-07-18 2004-04-20 Aegis Analytical Corporation System, method and computer program for assembling process data of multi-database origins using a hierarchical display
AU2001280746A1 (en) 2000-07-21 2002-02-05 Phase-1 Molecular Toxicology Canine toxicity genes
US20050181421A1 (en) * 2000-08-03 2005-08-18 Affymetrix, Inc. Methods of array synthesis
US7198924B2 (en) 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
EP1573634A2 (en) 2000-08-22 2005-09-14 Affymetrix, Inc. System method, and computer software product for controlling biological microarray scanner
EP1387894A4 (en) * 2000-08-24 2006-10-11 Aviva Biosciences Corp METHODS AND COMPOSITIONS FOR IDENTIFYING NUCLEIC ACID MOLECULES USING NUCLEOLYTIC ACTIVITIES AND HYBRIDIZATION
US6713257B2 (en) 2000-08-25 2004-03-30 Rosetta Inpharmatics Llc Gene discovery using microarrays
US7807447B1 (en) 2000-08-25 2010-10-05 Merck Sharp & Dohme Corp. Compositions and methods for exon profiling
US20020164634A1 (en) * 2000-08-26 2002-11-07 Perlegen Sciences, Inc. Methods for reducing complexity of nucleic acid samples
JP3537752B2 (ja) * 2000-09-01 2004-06-14 日立ソフトウエアエンジニアリング株式会社 バイオチップを用いたハイブリダイゼーション反応の実験結果表示方法及び実験誤差評価方法
US7108969B1 (en) 2000-09-08 2006-09-19 Affymetrix, Inc. Methods for detecting and diagnosing oral cancer
EP1186673A3 (en) * 2000-09-11 2003-03-26 Agilent Technologies, Inc. (a Delaware corporation) Calibration of molecular array data
GB0022978D0 (en) 2000-09-19 2000-11-01 Oxford Glycosciences Uk Ltd Detection of peptides
WO2002027321A2 (en) 2000-09-26 2002-04-04 Health Research Incorporated Analysis of hiv-1 coreceptor use in the clinical care of hiv-1-infected patients
US7129044B2 (en) 2000-10-04 2006-10-31 The Board Of Trustees Of The Leland Stanford Junior University Renaturation, reassociation, association and hybridization of nucleic acid molecules
US6368806B1 (en) * 2000-10-05 2002-04-09 Pioneer Hi-Bred International, Inc. Marker assisted identification of a gene associated with a phenotypic trait
AU3118602A (en) * 2000-10-18 2002-04-29 Genomic Health Inc Genomic profile information systems and methods
IL155450A0 (en) * 2000-10-20 2003-11-23 Expression Diagnostics Inc Leukocyte expression profiling
US6998234B2 (en) * 2000-11-03 2006-02-14 Oncotech, Inc. Methods for cancer prognosis and diagnosis relating to tumor vascular endothelial cells
WO2002040634A2 (en) * 2000-11-14 2002-05-23 Genetag Technology, Inc. Expression miniarrays and uses thereof
US7117095B2 (en) 2000-11-21 2006-10-03 Affymetrix, Inc. Methods for selecting nucleic acid probes
US20030104393A1 (en) * 2000-11-28 2003-06-05 Sharp Frank R. Blood assessment of injury
AU2002221046A1 (en) * 2000-12-06 2002-06-18 Takara Shuzo Co., Ltd. Functional dna array
US7197400B2 (en) * 2000-12-12 2007-03-27 Affymetrix, Inc. System and computer software products for comparative gene expression analysis
US6858413B2 (en) 2000-12-13 2005-02-22 Nugen Technologies, Inc. Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof
US6391592B1 (en) * 2000-12-14 2002-05-21 Affymetrix, Inc. Blocker-aided target amplification of nucleic acids
US6448387B1 (en) * 2000-12-18 2002-09-10 Monsanto Technology, Llc Polymeric arrays adapted for high expressing polynucleotides
US20030003450A1 (en) * 2000-12-21 2003-01-02 Affymetrix, Inc. Computer software products for gene expression analysis using linear programming
AU2002246978A1 (en) * 2001-01-10 2002-07-24 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface
WO2002059271A2 (en) * 2001-01-25 2002-08-01 Gene Logic, Inc. Gene expression profiles in breast tissue
US7226737B2 (en) * 2001-01-25 2007-06-05 Luminex Molecular Diagnostics, Inc. Polynucleotides for use as tags and tag complements, manufacture and use thereof
ATE546545T1 (de) * 2001-01-25 2012-03-15 Luminex Molecular Diagnostics Inc Polynukleotide zur verwendung als tags und tag komplemente, herstellung und verwendung derselben
US7309811B2 (en) * 2001-02-23 2007-12-18 Elan Pharmaceuticals, Inc Transgenic mice knockouts of BACE-1
JP2002262876A (ja) * 2001-03-07 2002-09-17 Ngk Insulators Ltd 高感度な核酸のハイブリダイゼーション方法、及びその方法を用いた遺伝子解析方法
NZ523167A (en) * 2001-03-09 2006-08-31 Nugen Technologies Inc Methods, compositions and kits for amplifying RNA sequences of interest which employ an RNA/DNA composite primer
US20040076954A1 (en) * 2001-03-12 2004-04-22 Irm, Llc Genomics-driven high speed cellular assays, development thereof, and collections of cellular reporters
US20030104410A1 (en) * 2001-03-16 2003-06-05 Affymetrix, Inc. Human microarray
US7047141B2 (en) * 2001-03-22 2006-05-16 Ge Healthcare Bio-Sciences Ab Ratio-based oligonucleotide probe selection
US7563618B2 (en) * 2001-03-23 2009-07-21 Geron Corporation Oligonucleotide conjugates
US20020142305A1 (en) * 2001-03-27 2002-10-03 Koei Chin Methods for diagnosing and monitoring ovarian cancer by screening gene copy numbers
JP4091437B2 (ja) * 2001-03-28 2008-05-28 クロンディアグ チップ テヒノロギーズ ゲーエムベーハー 蛍光信号参照デバイス
US7115726B2 (en) * 2001-03-30 2006-10-03 Perlegen Sciences, Inc. Haplotype structures of chromosome 21
AU785425B2 (en) * 2001-03-30 2007-05-17 Genetic Technologies Limited Methods of genomic analysis
US6596489B2 (en) * 2001-03-30 2003-07-22 Applied Gene Technologies Methods and compositions for analyzing nucleotide sequence mismatches using RNase H
US7618789B2 (en) * 2001-04-06 2009-11-17 The United States Of America As Represented By The Secretary Of Department Of Health And Human Services Use of semenogelin in the diagnosis, prognosis and treatment of cancer
US20030148339A1 (en) * 2001-05-07 2003-08-07 Hrissi Samartzidou Artificial genes for use as controls in gene expression analysis systems
US6943242B2 (en) * 2001-05-07 2005-09-13 Amersham Biosciences Corp. Design of artificial genes for use as controls in gene expression analysis systems
US7138506B2 (en) 2001-05-09 2006-11-21 Genetic Id, Na, Inc. Universal microarray system
US20040014086A1 (en) * 2001-05-11 2004-01-22 Regulome Corporation Regulome arrays
US6924113B2 (en) 2001-06-08 2005-08-02 Panomics, Inc. Method and kit for isolating DNA probes that bind to activated transcription factors
US7026121B1 (en) * 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US6905827B2 (en) * 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US6821737B2 (en) 2001-06-08 2004-11-23 Panomics, Inc. Method for screening for drug candidates for modulating transcription factor activity
US7981842B2 (en) 2001-06-08 2011-07-19 Panomics, Inc. Method for detecting transcription factor-protein interactions
US6696256B1 (en) 2001-06-08 2004-02-24 Pandmics, Inc. Method, array and kit for detecting activated transcription factors by hybridization array
US20040214166A1 (en) * 2001-06-08 2004-10-28 Xianqiang Li Method for identifying a disease state based on a detected mixture of activated transcription factors
US20030104426A1 (en) * 2001-06-18 2003-06-05 Linsley Peter S. Signature genes in chronic myelogenous leukemia
US20050175989A1 (en) * 2001-06-20 2005-08-11 Ching-Yu Lin Method and detector for identifying subtypes of human papilloma viruses
US7402286B2 (en) * 2001-06-27 2008-07-22 The Regents Of The University Of California Capillary pins for high-efficiency microarray printing device
US6855538B2 (en) * 2001-06-27 2005-02-15 The Regents Of The University Of California High-efficiency microarray printing device
US20040161741A1 (en) 2001-06-30 2004-08-19 Elazar Rabani Novel compositions and processes for analyte detection, quantification and amplification
US9777312B2 (en) * 2001-06-30 2017-10-03 Enzo Life Sciences, Inc. Dual polarity analysis of nucleic acids
US9261460B2 (en) 2002-03-12 2016-02-16 Enzo Life Sciences, Inc. Real-time nucleic acid detection processes and compositions
US6691042B2 (en) 2001-07-02 2004-02-10 Rosetta Inpharmatics Llc Methods for generating differential profiles by combining data obtained in separate measurements
AU2002322458A1 (en) * 2001-07-13 2003-01-29 Nanosphere, Inc. Method for immobilizing molecules onto surfaces
US7297553B2 (en) * 2002-05-28 2007-11-20 Nanosphere, Inc. Method for attachment of silylated molecules to glass surfaces
GB0117631D0 (en) * 2001-07-19 2001-09-12 Syngenta Ltd Improvements in or relating to organic compounds
US7297778B2 (en) 2001-07-25 2007-11-20 Affymetrix, Inc. Complexity management of genomic DNA
US7348140B1 (en) 2001-07-25 2008-03-25 Acadia Pharmaceuticals, Inc. Clinical indications for genotyping polymorphic variants of G-protein coupled receptors
EP1572896A4 (en) * 2001-07-30 2006-06-07 Angiotech Biocoatings Corp PFROPFPOLYMERMATRIZES
US7189509B2 (en) * 2001-08-16 2007-03-13 Zhifeng Shao Analysis of gene expression profiles using sequential hybridization
US20030175740A1 (en) * 2001-08-16 2003-09-18 Mullinax Rebecca Lynn Compositions and methods comprising control nucleic acid
US20080026367A9 (en) * 2001-08-17 2008-01-31 Perlegen Sciences, Inc. Methods for genomic analysis
WO2003020952A2 (en) * 2001-08-31 2003-03-13 Gen-Probe Incorporated Affinity-shifted probes for quantifying analyte polynucleotides
US20050147984A1 (en) * 2001-08-31 2005-07-07 Clondiag Chip Technologies Gmbh Interaction detection on several probe arrays
WO2003021229A2 (en) * 2001-09-05 2003-03-13 The Brigham And Women's Hospital, Inc. Diagnostic and prognostic tests
US7622260B2 (en) * 2001-09-05 2009-11-24 The Brigham And Women's Hospital, Inc. Diagnostic and prognostic tests
US20060188875A1 (en) * 2001-09-18 2006-08-24 Perlegen Sciences, Inc. Human genomic polymorphisms
JP2005504534A (ja) 2001-09-19 2005-02-17 アメリカ合衆国政府 トランスダクチン−１及びトランスダクチン−２並びに遺伝性聴覚障害への適用
AU2002343443A1 (en) * 2001-09-28 2003-04-14 Whitehead Institute For Biomedical Research Classification of lung carcinomas using gene expression analysis
US20040053232A1 (en) * 2001-10-05 2004-03-18 Perlegen Sciences, Inc. Haplotype structures of chromosome 21
WO2003031656A1 (en) * 2001-10-05 2003-04-17 United States Environmental Protection Agency Genetic testing for male factor infertility
US7439346B2 (en) * 2001-10-12 2008-10-21 Perkinelmer Las Inc. Nucleic acids arrays and methods of use therefor
WO2003091426A1 (en) * 2001-10-12 2003-11-06 Spectral Genomics, Inc. Compilations of nucleic acids and arrays and methods of using them
EP1442141A4 (en) * 2001-10-17 2005-05-18 Univ Utah Res Found METHOD FOR IDENTIFYING DIFFERENTIALLY EXPRESSED GENES THROUGH MULTIVARIATE ANALYSIS OF MICROARRAY DATA
AU2002349976A1 (en) * 2001-10-17 2003-04-28 Advanced Research And Technology Institute Methods for predicting transcription levels
US20040126762A1 (en) * 2002-12-17 2004-07-01 Morris David W. Novel compositions and methods in cancer
CA2464839A1 (en) * 2001-10-24 2003-06-05 Amersham Biosciences (Sv) Corp. Artificial genes for use as controls in gene expression analysis systems
DE10155055A1 (de) * 2001-11-09 2003-05-28 Friz Biochem Gmbh Fluoreszenz-Quenchen zur Detektion von Nukleinsäure-Oligomer-Hybridisierungsereignissen bei hohen Salz-Konzentrationen
ES2345329T3 (es) 2001-11-09 2010-09-21 Georgetown University Nueva isoforma del inhibidor del crecimiento celular endotelial vascular (vegi).
US20030099952A1 (en) * 2001-11-26 2003-05-29 Roland Green Microarrays with visible pattern detection
US20040023237A1 (en) * 2001-11-26 2004-02-05 Perelegen Sciences Inc. Methods for genomic analysis
WO2003048295A1 (en) 2001-11-30 2003-06-12 Fluidigm Corporation Microfluidic device and methods of using same
US20060040262A1 (en) * 2002-12-27 2006-02-23 Morris David W Novel compositions and methods in cancer
US20040197778A1 (en) * 2002-12-26 2004-10-07 Sagres Discovery, Inc. Novel compositions and methods in cancer
TW200408407A (en) * 2001-11-30 2004-06-01 Dana Farber Cancer Inst Inc Methods and compositions for modulating the immune system and uses thereof
US6670122B2 (en) * 2001-12-03 2003-12-30 Affymetrix, Inc. Method for detecting transcription templates
EP1453973A4 (en) * 2001-12-11 2005-04-13 Affymetrix Inc Method for determining transcription activity
KR100442839B1 (ko) * 2001-12-15 2004-08-02 삼성전자주식회사 최적 탐침 설계를 위한 탐침의 점수화 및 선택에 관한 방법
CN1927466A (zh) * 2001-12-19 2007-03-14 阿菲梅特里克斯公司 阵列板和阵列板的构建方法
US20030124542A1 (en) * 2001-12-28 2003-07-03 Spectral Genomics, Inc. Methods for mapping the chromosomal loci of genes expressed by a cell
US20030166026A1 (en) * 2002-01-09 2003-09-04 Lynx Therapeutics, Inc. Identification of specific biomarkers for breast cancer cells
US20030170700A1 (en) * 2002-01-09 2003-09-11 Lynx Therapeutics, Inc. Secreted and cell surface polypeptides affected by cholesterol and uses thereof
US20030143547A1 (en) * 2002-01-24 2003-07-31 Xianqiang Li Method for identifying multiple activated transcription factors
US7418351B2 (en) * 2002-01-31 2008-08-26 Rosetta Inpharmatics Llc Methods for analysis of measurement errors in measured signals
US20030149593A1 (en) * 2002-02-04 2003-08-07 Msc Healthcare (S) Pte. Ltd. Health-care system
US7499806B2 (en) 2002-02-14 2009-03-03 Illumina, Inc. Image processing in microsphere arrays
US7375206B2 (en) 2002-02-22 2008-05-20 The United States Of America As Represented By The Department Of Health And Human Services Brother of the regulator of imprinted sites (BORIS)
DE10208794A1 (de) * 2002-02-28 2003-09-04 Degussa Bioactives Gmbh Verfahren zum Sortieren einsträngiger Nucleinsäuren
US9353405B2 (en) 2002-03-12 2016-05-31 Enzo Life Sciences, Inc. Optimized real time nucleic acid detection processes
US20030233197A1 (en) * 2002-03-19 2003-12-18 Padilla Carlos E. Discrete bayesian analysis of data
AU2003218350A1 (en) * 2002-03-21 2003-10-08 Sagres Discovery, Inc. Novel compositions and methods in cancer
US20030186220A1 (en) * 2002-03-28 2003-10-02 Jizhong Zhou Detecting microorganisms using whole genomic DNA or RNA microarray
US6773888B2 (en) 2002-04-08 2004-08-10 Affymetrix, Inc. Photoactivatable silane compounds and methods for their synthesis and use
US20030195431A1 (en) * 2002-04-10 2003-10-16 Sukhatme Vikas P. Observation of effects of body fluids on indicator cells for disease diagnosis
US7687256B2 (en) * 2002-04-11 2010-03-30 Spire Corporation Surface activated biochip
US8383342B2 (en) 2002-04-24 2013-02-26 The University Of North Carolina At Greensboro Compositions, products, methods and systems to monitor water and other ecosystems
US8048623B1 (en) 2002-04-24 2011-11-01 The University Of North Carolina At Greensboro Compositions, products, methods and systems to monitor water and other ecosystems
US9126165B1 (en) 2002-04-24 2015-09-08 The University Of North Carolina At Greensboro Nucleic acid arrays to monitor water and other ecosystems
US20040023275A1 (en) * 2002-04-29 2004-02-05 Perlegen Sciences, Inc. Methods for genomic analysis
US20040009512A1 (en) * 2002-05-02 2004-01-15 Manuel Ares Arrays for detection of products of mRNA splicing
US20060052320A1 (en) * 2002-05-06 2006-03-09 Limin Li Mammalian genes involved in rapamycin resistance and tumorgenesis annexin XIII genes
US20040018522A1 (en) * 2002-05-09 2004-01-29 Brigham And Women's Hospital, Inc. Identification of dysregulated genes in patients with multiple sclerosis
US6890719B2 (en) 2002-05-10 2005-05-10 The Board Of Trustess Of The University Of Illinois Fluorescence based biosensor
US7534560B2 (en) * 2002-05-10 2009-05-19 The Board Of Trustees Of The University Of Illinois Simple catalytic DNA biosensors for ions based on color changes
US9388459B2 (en) 2002-06-17 2016-07-12 Affymetrix, Inc. Methods for genotyping
US7332273B2 (en) 2002-06-20 2008-02-19 Affymetrix, Inc. Antireflective coatings for high-resolution photolithographic synthesis of DNA arrays
US7894998B2 (en) * 2002-06-26 2011-02-22 Agilent Technologies, Inc. Method for identifying suitable nucleic acid probe sequences for use in nucleic acid arrays
JP2005531315A (ja) * 2002-06-28 2005-10-20 ロゼッタ インファーマティクス エルエルシー マイクロアレイの品質を評価する方法
US7504215B2 (en) 2002-07-12 2009-03-17 Affymetrix, Inc. Nucleic acid labeling methods
JP2005532829A (ja) * 2002-07-18 2005-11-04 インヴィトロジェン コーポレーション 組換え部位を含むウイルスベクター
DE60332948D1 (de) * 2002-07-19 2010-07-22 Althea Technologies Inc Strategien zur genexpressionsanalyse
AU2003265525A1 (en) * 2002-08-15 2004-03-19 Functional Genetics, Inc. Mammalian genes involved in rapamycin resistance and tumorgenesis: rapr7 genes
WO2004020582A2 (en) * 2002-08-15 2004-03-11 Functional Genetics, Inc. Mammalian genes involved in rapamycin resistance and tumorgenesis: rapr6 genes
EP1546404A2 (en) * 2002-09-11 2005-06-29 Exiqon A/S A population of nucleic acids including a subpopulation of lna oligomers
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
US7482170B2 (en) * 2002-09-30 2009-01-27 Roche Nimblegen, Inc. Parallel loading of arrays
JP2006500954A (ja) * 2002-10-01 2006-01-12 ニンブルゲン システムズ インコーポレイテッド 単一のアレイ特徴部に複数のオリゴヌクレオチドを有するマイクロアレイ
US20040259105A1 (en) * 2002-10-03 2004-12-23 Jian-Bing Fan Multiplex nucleic acid analysis using archived or fixed samples
US20040067492A1 (en) * 2002-10-04 2004-04-08 Allan Peng Reverse transcription on microarrays
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
US20040161424A1 (en) * 2002-10-08 2004-08-19 Xenoport Human organic solute transporters
US20050003369A1 (en) * 2002-10-10 2005-01-06 Affymetrix, Inc. Method for depleting specific nucleic acids from a mixture
US6863822B2 (en) * 2002-10-16 2005-03-08 Anthony Pipes Method and apparatus for parallel desalting
US20040219565A1 (en) 2002-10-21 2004-11-04 Sakari Kauppinen Oligonucleotides useful for detecting and analyzing nucleic acids of interest
AU2003284921A1 (en) * 2002-10-22 2004-05-13 Iconix Pharmaceuticals, Inc. Reticulocyte depletion signatures
US7822555B2 (en) 2002-11-11 2010-10-26 Affymetrix, Inc. Methods for identifying DNA copy number changes
US20040235008A1 (en) * 2002-11-14 2004-11-25 Affymetrix, Inc. Methods and compositions for profiling transcriptionally active sites of the genome
AU2002952696A0 (en) 2002-11-14 2002-11-28 Genomics Research Partners Pty Ltd Status determination
GB0227238D0 (en) * 2002-11-21 2002-12-31 Diagenic As Product and method
JP2006508662A (ja) 2002-12-04 2006-03-16 アプレラ コーポレイション ポリヌクレオチドの多重増幅
US7778782B1 (en) 2002-12-17 2010-08-17 Entelos, Inc. Peroxisome proliferation activated receptor alpha (PPARα) signatures
US7396645B1 (en) 2002-12-17 2008-07-08 Entelos, Inc. Cholestasis signature
US7519519B1 (en) 2002-12-20 2009-04-14 Entelos, Inc. Signature projection score
US7422854B1 (en) 2002-12-20 2008-09-09 Entelos, Inc. Cholesterol reduction signature
US7996155B2 (en) 2003-01-22 2011-08-09 Microsoft Corporation ANOVA method for data analysis
US7767387B2 (en) * 2003-06-13 2010-08-03 Sagres Discovery, Inc. Therapeutic targets in cancer
US20070218071A1 (en) * 2003-09-15 2007-09-20 Morris David W Novel therapeutic targets in cancer
US7192703B2 (en) * 2003-02-14 2007-03-20 Intel Corporation, Inc. Biomolecule analysis by rolling circle amplification and SERS detection
EP1592708A2 (en) 2003-02-14 2005-11-09 Sagres Discovery, Inc. Therapeutic gpcr targets in cancer
US20090124514A1 (en) * 2003-02-26 2009-05-14 Perlegen Sciences, Inc. Selection probe amplification
US20060183132A1 (en) * 2005-02-14 2006-08-17 Perlegen Sciences, Inc. Selection probe amplification
DK2374900T3 (en) * 2003-03-07 2016-10-17 Rubicon Genomics Inc Polynucleotides for amplification and analysis of the total genomic and total transcription libraries generated by a DNA polymerization
US8206913B1 (en) 2003-03-07 2012-06-26 Rubicon Genomics, Inc. Amplification and analysis of whole genome and whole transcriptome libraries generated by a DNA polymerization process
US7612185B2 (en) * 2003-03-07 2009-11-03 The Board Of Trustees Of The University Of Illinois Nucleic acid biosensors
US6970240B2 (en) * 2003-03-10 2005-11-29 Applera Corporation Combination reader
FR2852317B1 (fr) 2003-03-13 2006-08-04 Biopuces a sondes et leurs methodes d'utilisation
EP2390352A1 (en) 2003-03-18 2011-11-30 Quantum Genetics Ireland Limited Systems and methods for improving protein and milk production of dairy herds
US20040185451A1 (en) * 2003-03-21 2004-09-23 Leproust Eric M. Methods for detecting the presence of a nucleic acid analyte in a sample
US20040248286A1 (en) * 2003-03-21 2004-12-09 Christine Konradi Nucleic acid molecules that are differentially regulated in a bipolar disorder and uses thereof
CA2458085A1 (en) 2003-03-21 2004-09-21 F. Hoffmann-La Roche Ag Transcriptional activity assay
EP1615721B1 (en) 2003-04-03 2014-06-18 Fluidigm Corporation Microfluidic devices and methods of using same
US7833714B1 (en) 2003-04-11 2010-11-16 Affymetrix, Inc. Combinatorial affinity selection
US7402386B2 (en) 2003-04-14 2008-07-22 Nugen Technologies, Inc. Global amplification using random priming by a composite primer
US7892745B2 (en) * 2003-04-24 2011-02-22 Xdx, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US20050026181A1 (en) * 2003-04-29 2005-02-03 Genvault Corporation Bio bar-code
US20040219533A1 (en) * 2003-04-29 2004-11-04 Jim Davis Biological bar code
WO2004097005A2 (en) * 2003-04-29 2004-11-11 University Of Georgia Research Foundation, Inc. Global analysis of transposable elements as molecular markers of the developmental potential of stem cells
US20040229224A1 (en) * 2003-05-13 2004-11-18 Perlegen Sciences, Inc. Allele-specific expression patterns
US8609830B2 (en) * 2003-05-16 2013-12-17 Merck Sharp & Dohme Corp. Methods and compositions for RNA interference
EP1480155A3 (en) * 2003-05-19 2008-12-03 Canon Kabushiki Kaisha Information processing apparatus, information processing method, storage medium and program
DE10322912A1 (de) * 2003-05-21 2004-12-16 Bayer Technology Services Gmbh Verfahren zum Nachweis von Nukleinsäuren
EP1631690A2 (en) * 2003-05-23 2006-03-08 Cold Spring Harbor Laboratory Counting exact word matches in genomes
US20050014168A1 (en) * 2003-06-03 2005-01-20 Arcturus Bioscience, Inc. 3' biased microarrays
US20050221310A1 (en) * 2003-06-06 2005-10-06 Gene Ogic, Inc. Methods for enhancing gene expression analysis
WO2005003370A2 (en) * 2003-06-06 2005-01-13 Gene Logic, Inc. Methods for enhancing gene expression analysis
EP2327796A1 (en) 2003-06-10 2011-06-01 The Trustees Of Boston University Detection methods for disorders of the lung
US20050064462A1 (en) * 2003-06-17 2005-03-24 Bernd Stein Methods, compositions, and kits for predicting the effect of compounds on hot flash symptoms
US7642064B2 (en) 2003-06-24 2010-01-05 Ventana Medical Systems, Inc. Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest
DE602004022165D1 (de) 2003-06-24 2009-09-03 Ventana Med Syst Inc Enzymkatalysierte metalldeposition zum verstärkten und nukleinsäuresequenzen
WO2005028615A2 (en) * 2003-06-26 2005-03-31 Invitrogen Corporation Methods and compositions for detecting promoter activity and expressing fusion proteins
US20050100911A1 (en) * 2003-08-06 2005-05-12 Perlegen Sciences, Inc. Methods for enriching populations of nucleic acid samples
US20050064483A1 (en) * 2003-08-28 2005-03-24 Baylor College Of Medicine Gene expression profiling technology for treatment evaluation of multiple sclerosis
US7108979B2 (en) * 2003-09-03 2006-09-19 Agilent Technologies, Inc. Methods to detect cross-contamination between samples contacted with a multi-array substrate
US8131475B2 (en) 2003-09-03 2012-03-06 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Methods for identifying, diagnosing, and predicting survival of lymphomas
EP1664762A4 (en) 2003-09-03 2008-08-13 Us Gov Health & Human Serv METHOD OF IDENTIFYING AND DIAGNOSIS OF, AND VIEWING, SURVIVAL IN LYMPHOMA
US7335474B2 (en) * 2003-09-12 2008-02-26 Perlegen Sciences, Inc. Methods and systems for identifying predisposition to the placebo effect
US7964344B2 (en) * 2003-09-17 2011-06-21 Canon Kabushiki Kaisha Stable hybrid
US20070281896A1 (en) * 2003-09-30 2007-12-06 Morris David W Novel compositions and methods in cancer
EP1524320A1 (en) * 2003-10-15 2005-04-20 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Rapid determination and quantification of mycoplasma contamination using DNA chip technology
WO2005038052A2 (en) * 2003-10-15 2005-04-28 Altana Pharma Ag Method for identifying interferon mimics
US20050227251A1 (en) 2003-10-23 2005-10-13 Robert Darnell Method of purifying RNA binding protein-RNA complexes
WO2005047545A2 (en) * 2003-11-04 2005-05-26 Applera Corporation Microarray controls
WO2005047546A2 (en) * 2003-11-05 2005-05-26 Wisconsin Alumni Research Foundation Diagnostic and prognostic methods and compositions for seizure- and plasticity-related disorders
US8304189B2 (en) * 2003-12-01 2012-11-06 Life Technologies Corporation Nucleic acid molecules containing recombination sites and methods of using the same
WO2005055804A2 (en) * 2003-12-02 2005-06-23 Musc Foundation For Research Development Methods and compositions for diagnosing epithelial cell cancer
EP1541696A1 (en) * 2003-12-09 2005-06-15 Institut Pasteur A DNA macro-array for staphylococcus aureus identification and typing
JP4508632B2 (ja) * 2003-12-25 2010-07-21 キヤノン株式会社 核酸検出方法及び液組成物
JP2005190427A (ja) * 2003-12-26 2005-07-14 Canon Inc 配列を同定するための変異要素のセット抽出方法
US7485419B2 (en) * 2004-01-13 2009-02-03 The Board Of Trustees Of The University Of Illinois Biosensors based on directed assembly of particles
WO2005071114A1 (en) * 2004-01-15 2005-08-04 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method evolved for recognition of thrombophilia (mert)
WO2005070020A2 (en) * 2004-01-23 2005-08-04 The Regents Of The University Of Colorado Gefitinib sensitivity-related gene expression and products and methods related thereto
EP1564306B1 (en) 2004-02-17 2013-08-07 Affymetrix, Inc. Methods for fragmenting and labeling DNA
EP1718770B1 (en) 2004-02-19 2011-05-25 The Governors of the University of Alberta Leptin promoter polymorphisms and uses thereof
US7981616B2 (en) * 2004-02-27 2011-07-19 Musc Foundation For Research Development Enhanced detection of RNA using a panel of truncated gene-specific primers for reverse transcription
US7166433B2 (en) * 2004-03-03 2007-01-23 The United States Of America As Represented By The Department Of Health And Human Services Transductin-1 and transductin-2 and applications to hereditary deafness
US20070161001A1 (en) * 2004-03-04 2007-07-12 Dena Leshkowitz Quantifying and profiling antibody and t cell receptor gene expression
US7881872B2 (en) * 2004-03-12 2011-02-01 Microsoft Corporation Methods of analyzing multi-channel profiles
JP4545189B2 (ja) 2004-03-24 2010-09-15 トライパス イメイジング インク 子宮頸部疾患を検出するための方法及び組成物
US7468249B2 (en) * 2004-05-05 2008-12-23 Biocept, Inc. Detection of chromosomal disorders
WO2005111242A2 (en) * 2004-05-10 2005-11-24 Parallele Bioscience, Inc. Digital profiling of polynucleotide populations
AU2005280659A1 (en) * 2004-05-11 2006-03-09 Wyeth Novel polynucleotides related to oligonucleotide arrays to monitor gene expression
JP2008500057A (ja) * 2004-05-27 2008-01-10 バーテックス　ファーマシューティカルズ　インコーポレイテッド Ｉｍｐｄｈ経路の阻害をモニタリングするためのバイオマーカー
WO2005117553A2 (en) * 2004-05-27 2005-12-15 The Regents Of The University Of Colorado Methods for prediction of clinical outcome to epidermal growth factor receptor inhibitors by cancer patients
EP2474616B1 (en) * 2004-05-28 2015-07-08 Asuragen, Inc. Methods and compositions involving microRNA
GB0412301D0 (en) * 2004-06-02 2004-07-07 Diagenic As Product and method
US7338763B2 (en) 2004-06-02 2008-03-04 Eppendorf Array Technologies S.A. Method and kit for the detection and/or quantification of homologous nucleotide sequences on arrays
US20060004526A1 (en) * 2004-07-01 2006-01-05 Ambion, Inc. System and method for processing results of a complex genetic test
US8965710B2 (en) * 2004-07-02 2015-02-24 The United States Of America, As Represented By The Secretary Of The Navy Automated sample-to-microarray apparatus and method
JP4794832B2 (ja) * 2004-07-02 2011-10-19 キヤノン株式会社 核酸検出用プローブセット及び担体
EP2468889A3 (en) * 2004-07-09 2012-07-11 University of Pittsburgh of the Commonwealth System of Higher Education Identification of markers in lung and breast cancer
US20060024677A1 (en) 2004-07-20 2006-02-02 Morris David W Novel therapeutic targets in cancer
AU2005269527B2 (en) 2004-07-26 2011-12-01 Pfenex Inc. Process for improved protein expression by strain engineering
US7645575B2 (en) * 2004-09-08 2010-01-12 Xdx, Inc. Genes useful for diagnosing and monitoring inflammation related disorders
EP1647600A3 (en) 2004-09-17 2006-06-28 Affymetrix, Inc. (A US Entity) Methods for identifying biological samples by addition of nucleic acid bar-code tags
WO2006037130A2 (en) * 2004-09-27 2006-04-06 Viagen, Inc. Method of targeted and comprehensive sequencing using high-density oligonucleotide array
AU2005335216A1 (en) * 2004-10-05 2007-02-15 Wyeth Probe arrays for detecting multiple strains of different species
US20060073511A1 (en) 2004-10-05 2006-04-06 Affymetrix, Inc. Methods for amplifying and analyzing nucleic acids
EP1529849A3 (en) * 2004-10-06 2005-11-02 De Ceuster NV Reliable method for assessing and reporting the risks of disease, contamination and losses caused by one or more microorganisms in a matrix or environment
JP5269412B2 (ja) 2004-10-07 2013-08-21 アルゴス セラピューティクス，インコーポレイティド 成熟樹状細胞組成物およびその培養方法
US8173367B2 (en) * 2004-10-18 2012-05-08 Sherri Boucher In situ dilution of external controls for use in microarrays
CA2524964A1 (en) 2004-10-29 2006-04-29 Affymetrix, Inc. Automated method of manufacturing polymer arrays
US7682782B2 (en) 2004-10-29 2010-03-23 Affymetrix, Inc. System, method, and product for multiple wavelength detection using single source excitation
US20060094026A1 (en) * 2004-11-03 2006-05-04 Yi Lu Nucleic acid enzyme light-up sensor utilizing invasive DNA
EP1838852A2 (en) 2004-11-12 2007-10-03 Asuragen, Inc. Methods and compositions involving mirna and mirna inhibitor molecules
US20090088328A1 (en) * 2004-11-23 2009-04-02 Quest Diagnostics Investments Incorporated Microarray Quality Control
WO2006060742A2 (en) * 2004-12-02 2006-06-08 Oncotech, Inc. Reagents and methods for predicting drug resistance
BRPI0520207A2 (pt) 2004-12-08 2012-09-25 Revision Therapeutics Inc uso de uma quantidade eficaz de um primeiro composto, e, medicamento sistemicamente formulado
US20060166222A1 (en) * 2005-01-21 2006-07-27 Yi Lu Nucleic acid enzyme ligation sensor
US20060188909A1 (en) * 2005-01-21 2006-08-24 Medical College Of Ohio Business methods for assessing nucleic acids
JP2006217897A (ja) 2005-02-14 2006-08-24 Canon Inc コントロールブローブ用塩基配列及びその設計方法
EP2522757A1 (en) 2005-02-18 2012-11-14 Monogram BioSciences, Inc. Methods and compositions for determining anti-HIV drug susceptibility and replication capacity of HIV
WO2006089045A2 (en) 2005-02-18 2006-08-24 Monogram Biosciences, Inc. Methods and compositions for determining hypersusceptibility of hiv-1 to non-nucleoside reverse transcriptase inhibitors
US20080234265A1 (en) * 2005-03-11 2008-09-25 The Regents Of The University Of Colorado Histone Deacetylase Inhibitors Sensitize Cancer Cells to Epidermal Growth Factor Inhibitors
WO2006099421A2 (en) 2005-03-14 2006-09-21 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for evaluating graft survival in a solid organ transplant recipient
EP2518161A1 (en) 2005-03-18 2012-10-31 Fluidigm Corporation Method for detection of mutant alleles
US20070092886A1 (en) * 2005-03-22 2007-04-26 Raymond Tabibiazar Methods and compositions for diagnosis, monitoring and development of therapeutics for treatment of atherosclerotic disease
US20060246576A1 (en) * 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
AU2006235276A1 (en) 2005-04-07 2006-10-19 Novartis Vaccines And Diagnostics Inc. CACNA1E in cancer diagnosis, detection and treatment
EP1871911A2 (en) 2005-04-07 2008-01-02 Chiron Corporation Cancer-related genes (prlr)
WO2006113467A2 (en) 2005-04-14 2006-10-26 The Trustees Of Boston University Diagnostic for lung disorders using class prediction
EP1877533A2 (en) * 2005-04-18 2008-01-16 Dsm Ip Assets B.V. Biochip and process for the production of a biochip
WO2006122295A2 (en) * 2005-05-11 2006-11-16 Expression Diagnostics, Inc. Methods of monitoring functional status of transplants using gene panels
US20070072175A1 (en) * 2005-05-13 2007-03-29 Biogen Idec Ma Inc. Nucleotide array containing polynucleotide probes complementary to, or fragments of, cynomolgus monkey genes and the use thereof
JP2006322741A (ja) * 2005-05-17 2006-11-30 Canon Inc プローブアレイを用いたハイブリダイゼーションデータ処理方法
HRP20130852T1 (en) 2005-05-18 2013-10-25 Novartis Ag Methods for diagnosis and treatment of diseases having an autoimmune and/or inflammatory component
US20090087841A1 (en) * 2005-05-27 2009-04-02 Monogram Biosciences, Inc. Methods and compositions for determining resistance of hiv-1 to protease inhibitors
US9506121B2 (en) 2005-06-06 2016-11-29 Monogram Biosciences, Inc. Methods for determining resistance or susceptibility to HIV entry inhibitors
WO2006133267A2 (en) * 2005-06-06 2006-12-14 Monogram Biosciences, Inc. Methods and compositions for determining altered susceptibility of hiv-1 to anti-hiv drugs
EP1731620A1 (en) 2005-06-07 2006-12-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for the diagnosis of immune graft tolerance
US20070072205A1 (en) * 2005-06-09 2007-03-29 Yi Lu Nanomaterial error correction
JP4733456B2 (ja) * 2005-07-26 2011-07-27 シスメックス株式会社 前処理の外部精度管理方法、核酸検出処理の外部精度管理方法、検量線作成処理の外部精度管理方法、前処理の外部精度管理コンピュータ、核酸検出処理の外部精度管理コンピュータ、検量線作成処理の外部精度管理コンピュータ、前処理装置、及び核酸検出装置
CN1908189A (zh) * 2005-08-02 2007-02-07 博奥生物有限公司 体外辅助鉴定肠型胃癌及其分化程度的方法与专用试剂盒
US20070029205A1 (en) * 2005-08-08 2007-02-08 Shoou-Aaey Chen Method of surface treatment for metal and nonmetal surfaces
US7892734B2 (en) * 2005-08-11 2011-02-22 The Board Of Trustees Of The University Of Illinois Aptamer based colorimetric sensor systems
CA2621267A1 (en) 2005-09-07 2007-03-15 Nugen Technologies, Inc. Improved nucleic acid amplification procedure
ATE389035T1 (de) 2005-09-13 2008-03-15 Eppendorf Array Tech Sa Verfahren zum nachweis von homologen sequenzen, welche sich durch eine base unterscheiden, auf einem mikroarray
US7608395B2 (en) 2005-09-15 2009-10-27 Baylor Research Institute Systemic lupus erythematosus diagnostic assay
JP5037511B2 (ja) 2005-09-21 2012-09-26 ルミネックス コーポレーション 画像データ処理の方法及びシステム
US7962291B2 (en) 2005-09-30 2011-06-14 Affymetrix, Inc. Methods and computer software for detecting splice variants
CA2624896C (en) 2005-10-07 2017-11-07 Callida Genomics, Inc. Self-assembled single molecule arrays and uses thereof
EP1941057A4 (en) * 2005-10-07 2009-11-11 Baylor Res Inst DIAGNOSIS OF THE SYSTEMIC OUTBREAK OF JUVENIL IDIOPATHIC ARTHRITIS ABOUT BLOOD LEUKOCYTE MICROARRAY ANALYSIS
US20070092904A1 (en) * 2005-10-19 2007-04-26 Biogen Idec Ma Inc. Method for preparing limiting quantities of nucleic acids
US20070092903A1 (en) * 2005-10-24 2007-04-26 Fulmer-Smentek Stephanie B One-color microarray analysis methods, reagents and kits
US20080038714A1 (en) * 2005-11-02 2008-02-14 Affymetrix, Inc. Instrument to Pneumatically Control Lab Cards and Method Thereof
US8007267B2 (en) * 2005-11-02 2011-08-30 Affymetrix, Inc. System and method for making lab card by embossing
US20070099288A1 (en) * 2005-11-02 2007-05-03 Affymetrix, Inc. Microfluidic Methods, Devices, and Systems for Fluid Handling
US8075852B2 (en) * 2005-11-02 2011-12-13 Affymetrix, Inc. System and method for bubble removal
US20080311585A1 (en) * 2005-11-02 2008-12-18 Affymetrix, Inc. System and method for multiplex liquid handling
WO2007142692A2 (en) * 2005-11-14 2007-12-13 The Government Of The Usa, As Represented By The Secretary Of The Navy Automated sample-to-microarray system
DE102005056639A1 (de) * 2005-11-28 2007-06-06 Advalytix Ag Verfahren, Vorrichtung und Kit zur Untersuchung von Makromolekülen in einer Probe
US20070128611A1 (en) * 2005-12-02 2007-06-07 Nelson Charles F Negative control probes
US7634363B2 (en) 2005-12-07 2009-12-15 Affymetrix, Inc. Methods for high throughput genotyping
CA2630597A1 (en) 2005-12-08 2007-06-14 Novartis Ag Effects of inhibitors of fgfr3 on gene transcription
US20070238094A1 (en) 2005-12-09 2007-10-11 Baylor Research Institute Diagnosis, prognosis and monitoring of disease progression of systemic lupus erythematosus through blood leukocyte microarray analysis
JP4890936B2 (ja) * 2005-12-13 2012-03-07 岩手県 ２５塩基を超えるタグを固定化したアレイ（ＳｕｐｅｒＳＡＧＥ−Ａｒｒａｙ）による遺伝子発現解析
WO2007069882A1 (en) * 2005-12-13 2007-06-21 Erasmus University Medical Center Rotterdam Genetic brain tumor markers
US11306351B2 (en) 2005-12-21 2022-04-19 Affymetrix, Inc. Methods for genotyping
US20070212710A1 (en) * 2005-12-30 2007-09-13 Affymetrix, Inc. Competitive hybridization of dna probes and method of using the same
CA2637600A1 (en) 2006-01-17 2007-07-26 Health Research, Inc. Heteroduplex tracking assay
US20070172871A1 (en) * 2006-01-20 2007-07-26 Dishaw Larry J Methods for profiling transcriptosomes
US7537897B2 (en) 2006-01-23 2009-05-26 Population Genetics Technologies, Ltd. Molecular counting
BRPI0707249A2 (pt) 2006-01-27 2011-04-26 Tripath Imaging, Inc métodos para identificar pacientes com maior probabilidade de terem cáncer de ovário e composições para os mesmo
HUE041928T2 (hu) 2006-02-08 2019-06-28 Genzyme Corp Génterápia A-típusú Niemann-Pick-betegségre
GB2449048A (en) * 2006-02-15 2008-11-05 Agilent Technologies Inc Normalization probes for comparative genome hybridization arrays
JP2009529329A (ja) 2006-03-09 2009-08-20 トラスティーズ オブ ボストン ユニバーシティ 鼻腔上皮細胞の遺伝子発現プロファイルを用いた、肺疾患のための診断および予後診断の方法
US7799554B2 (en) * 2006-03-16 2010-09-21 The Board Of Trustees Of The University Of Illinois Lateral flow devices
EP2389948A1 (en) 2006-03-23 2011-11-30 Novartis AG Anti-tumor cell antigen antibody therapeutics
EP2007909A4 (en) * 2006-04-07 2011-01-26 Xdx Inc EXPRESSION OF NUCLEIC ACID IN RESPONSE TO STEROIDS AND PREDICTION OF DISEASE ACTIVITY
WO2007120658A1 (en) 2006-04-10 2007-10-25 Trustees Of Boston University Melanoma biomarker and methods of uses
JP2009534036A (ja) * 2006-04-21 2009-09-24 ワイス 細胞培養表現型の示差的発現プロファイリング分析およびその使用
US8383338B2 (en) * 2006-04-24 2013-02-26 Roche Nimblegen, Inc. Methods and systems for uniform enrichment of genomic regions
KR100772897B1 (ko) * 2006-05-02 2007-11-05 삼성전자주식회사 향상된 잡음률을 나타내는 올리고머 프로브 어레이 및 그제조 방법
US10522240B2 (en) 2006-05-03 2019-12-31 Population Bio, Inc. Evaluating genetic disorders
US7702468B2 (en) * 2006-05-03 2010-04-20 Population Diagnostics, Inc. Evaluating genetic disorders
US8163475B2 (en) * 2006-05-18 2012-04-24 The Mclean Hospital Corporation Methods for diagnosis and prognosis of psychotic disorders
BRPI0713098A2 (pt) 2006-05-22 2012-10-16 Clinical Genomics Pty Ltd método para determinar a origem anatÈmica de uma célula ou população celular derivada do intestino grosso de um indivìduo, método de detecção para determinar a origem anatÈmica de uma célula ou população celular derivada do intestino grosso de um indivìduo, sistema de detecção, meio de armazenagem legìvel por computador, arranjo de ácido nucleico, uso de um arranjo, método para determinar o inìcio ou predisposição para o inìcio de uma anormalidade celular ou uma condição destinguida por uma anormalidade celular no intestino grosso, kit de diagnóstico para ensaiar amostras biológicas
US7759062B2 (en) * 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
AU2007260676A1 (en) 2006-06-14 2007-12-21 Artemis Health, Inc. Rare cell analysis using sample splitting and DNA tags
US7629124B2 (en) * 2006-06-30 2009-12-08 Canon U.S. Life Sciences, Inc. Real-time PCR in micro-channels
JP2009543862A (ja) 2006-07-14 2009-12-10 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ガンのバイオマーカーおよびその使用方法
WO2008013918A2 (en) 2006-07-26 2008-01-31 Myelin Repair Foundation, Inc. Cell cycle regulation and differentiation
WO2008021290A2 (en) 2006-08-09 2008-02-21 Homestead Clinical Corporation Organ-specific proteins and methods of their use
US7993832B2 (en) * 2006-08-14 2011-08-09 Xdx, Inc. Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders
WO2008021115A2 (en) * 2006-08-14 2008-02-21 The Brigham And Women's Hospital, Inc. Diagnostic tests using gene expression ratios
US20080118910A1 (en) * 2006-08-31 2008-05-22 Milligan Stephen B Control nucleic acid constructs for use with genomic arrays
US7985542B2 (en) * 2006-09-07 2011-07-26 Institut Pasteur Genomic morse code
CA2663962A1 (en) 2006-09-19 2008-03-27 Asuragen, Inc. Mir-15, mir-26, mir-31,mir-145, mir-147, mir-188, mir-215, mir-216, mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention
US20090131348A1 (en) 2006-09-19 2009-05-21 Emmanuel Labourier Micrornas differentially expressed in pancreatic diseases and uses thereof
WO2008048986A2 (en) * 2006-10-17 2008-04-24 Children's Hospital Medical Center Gene array technique for predicting response in inflammatory bowel diseases
US9845494B2 (en) 2006-10-18 2017-12-19 Affymetrix, Inc. Enzymatic methods for genotyping on arrays
US20080102452A1 (en) * 2006-10-31 2008-05-01 Roberts Douglas N Control nucleic acid constructs for use in analysis of methylation status
JP2010508815A (ja) 2006-11-02 2010-03-25 イエール・ユニバーシテイ 卵母細胞受容能の評価
JP2010508826A (ja) 2006-11-03 2010-03-25 ベイラー リサーチ インスティテュート 血中白血球マイクロアレイ分析を介した、転移性メラノーマの診断及び免疫抑制インディケーターのモニタリング
WO2008140484A2 (en) * 2006-11-09 2008-11-20 Xdx, Inc. Methods for diagnosing and monitoring the status of systemic lupus erythematosus
US8293684B2 (en) * 2006-11-29 2012-10-23 Exiqon Locked nucleic acid reagents for labelling nucleic acids
US20080131878A1 (en) * 2006-12-05 2008-06-05 Asuragen, Inc. Compositions and Methods for the Detection of Small RNA
EP2104734A2 (en) * 2006-12-08 2009-09-30 Asuragen, INC. Mir-20 regulated genes and pathways as targets for therapeutic intervention
DK2104737T3 (da) * 2006-12-08 2013-05-27 Asuragen Inc Funktioner og formål for let-7 mikro-RNAer
CN101622349A (zh) * 2006-12-08 2010-01-06 奥斯瑞根公司 作为治疗性干预靶标的miR-21调节的基因和途径
EP2104735A2 (en) * 2006-12-08 2009-09-30 Asuragen, INC. Mir-21 regulated genes and pathways as targets for therapeutic intervention
CA2671270A1 (en) * 2006-12-29 2008-07-17 Asuragen, Inc. Mir-16 regulated genes and pathways as targets for therapeutic intervention
US8415461B2 (en) * 2007-01-19 2013-04-09 The Board Of Trustees Of The University Of Illinois Amphiphilic substances and functionalized lipid vesicles including the same
EA201201640A1 (ru) 2007-01-30 2013-09-30 Фармасайкликс, Инк. Способы определения устойчивости рака к ингибиторам гистондеацетилазы
WO2008106115A2 (en) 2007-02-26 2008-09-04 Monogram Biosciences, Inc. Compositions and methods for determining whether a subject would benefit from co-receptor inhibitor therapy
EP1961825A1 (en) 2007-02-26 2008-08-27 INSERM (Institut National de la Santé et de la Recherche Medicale) Method for predicting the occurrence of metastasis in breast cancer patients
US20080207960A1 (en) * 2007-02-28 2008-08-28 Eric Lin Methods, compositions, and kits for post-hybridization processing of arrays
US20080268442A1 (en) * 2007-04-24 2008-10-30 Igd Intel, Llc Method and system for preparing a blood sample for a disease association gene transcript test
US8058415B2 (en) 2007-04-24 2011-11-15 The Board Of Trustees Of The University Of Illinois Aptamer- and nucleic acid enzyme-based systems for simultaneous detection of multiple analytes
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
EP2615172A1 (en) 2007-04-27 2013-07-17 Pfenex Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
US8200440B2 (en) 2007-05-18 2012-06-12 Affymetrix, Inc. System, method, and computer software product for genotype determination using probe array data
US9096849B2 (en) * 2007-05-21 2015-08-04 The United States Of America, As Represented By The Secretary Of The Navy Solid phase for capture of nucleic acids
US20090232893A1 (en) * 2007-05-22 2009-09-17 Bader Andreas G miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
AU2008261951A1 (en) * 2007-06-08 2008-12-18 Asuragen, Inc. miR-34 regulated genes and pathways as targets for therapeutic intervention
US20090017460A1 (en) * 2007-06-15 2009-01-15 Wyeth Differential expression profiling analysis of cell culture phenotypes and uses thereof
WO2009009662A1 (en) * 2007-07-10 2009-01-15 University Of South Florida Method of predicting non-response to first line chemotherapy
US8409800B2 (en) * 2007-07-16 2013-04-02 The Board Of Trustees Of The University Of Illinois Nucleic acid based fluorescent sensor for copper detection
US8568690B2 (en) * 2007-07-31 2013-10-29 The Board Of Trustees Of The University Of Illinois MRI contrast agents and high-throughput screening by MRI
WO2009045632A2 (en) 2007-08-10 2009-04-09 The Board Of Trustees Of The University Of Illinois Nucleic acid based fluorescent sensor for mercury detection
US8361714B2 (en) * 2007-09-14 2013-01-29 Asuragen, Inc. Micrornas differentially expressed in cervical cancer and uses thereof
US9388457B2 (en) 2007-09-14 2016-07-12 Affymetrix, Inc. Locus specific amplification using array probes
US8716190B2 (en) 2007-09-14 2014-05-06 Affymetrix, Inc. Amplification and analysis of selected targets on solid supports
WO2009052386A1 (en) * 2007-10-18 2009-04-23 Asuragen, Inc. Micrornas differentially expressed in lung diseases and uses thereof
RU2565540C2 (ru) 2007-10-23 2015-10-20 Клиникал Джиномикс Пти. Лтд. Способ диагностики неоплазм-ii
EP2215258A4 (en) 2007-10-23 2010-12-01 Clinical Genomics Pty Ltd METHOD FOR DIAGNOSING NEOPLASMS
EP2053132A1 (en) 2007-10-23 2009-04-29 Roche Diagnostics GmbH Enrichment and sequence analysis of geomic regions
US8135545B2 (en) 2007-11-09 2012-03-13 Iverson Genetic Diagnostics, Inc. System and method for collecting data regarding broad-based neurotoxin-related gene mutation association
US20090125244A1 (en) * 2007-11-09 2009-05-14 Igd Intel Llc Broad-based neurotoxin-related gene mutation association from a gene transcript test
DE102007055386B4 (de) * 2007-11-20 2015-07-16 Boehringer Ingelheim Vetmedica Gmbh Verfahren zur Kalibrierung eines Sensorelements
WO2009070805A2 (en) * 2007-12-01 2009-06-04 Asuragen, Inc. Mir-124 regulated genes and pathways as targets for therapeutic intervention
ES2397672T3 (es) * 2007-12-05 2013-03-08 The Wistar Institute Of Anatomy And Biology Método de diagnóstico de cánceres de pulmón utilizando perfiles de expresión genética en células mononucleares de sangre periférica
US20090192114A1 (en) * 2007-12-21 2009-07-30 Dmitriy Ovcharenko miR-10 Regulated Genes and Pathways as Targets for Therapeutic Intervention
WO2009086215A2 (en) * 2007-12-21 2009-07-09 Wyeth Pathway analysis of cell culture phenotypes and uses thereof
EP2620511B1 (en) * 2008-01-17 2018-02-28 Sequenom, Inc. Single molecule nucleic acid sequence analysis processes
US8658379B2 (en) 2008-01-29 2014-02-25 University of Pittsburgh—of the Commonwealth System of Higher Education Follistatin-like protein-1 as a biomarker for sepsis
WO2009097424A1 (en) 2008-01-29 2009-08-06 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Fstl-1 as a biomarker of inflammation
WO2009100430A2 (en) * 2008-02-08 2009-08-13 Asuragen, Inc miRNAs DIFFERENTIALLY EXPRESSED IN LYMPH NODES FROM CANCER PATIENTS
US8034568B2 (en) * 2008-02-12 2011-10-11 Nugen Technologies, Inc. Isothermal nucleic acid amplification methods and compositions
JP5683964B2 (ja) 2008-03-11 2015-03-11 ナショナル キャンサー センター Ｓｎｐアレイを用いた染色体、遺伝子または特定ヌクレオチド配列のコピー数測定方法
US7846666B2 (en) 2008-03-21 2010-12-07 Nugen Technologies, Inc. Methods of RNA amplification in the presence of DNA
WO2009154835A2 (en) * 2008-03-26 2009-12-23 Asuragen, Inc. Compositions and methods related to mir-16 and therapy of prostate cancer
GB0809069D0 (en) 2008-05-19 2008-06-25 Univ Leuven Kath Gene signatures
US20090258928A1 (en) * 2008-04-08 2009-10-15 Asuragen, Inc. Methods and compositions for diagnosing and modulating human papillomavirus (hpv)
WO2009137369A1 (en) * 2008-05-03 2009-11-12 Tufts Medical Center, Inc. Neonatal salivary genomics
WO2009137807A2 (en) 2008-05-08 2009-11-12 Asuragen, Inc. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
JP5740302B2 (ja) 2008-05-30 2015-06-24 ザ ユニバーシティー オブ ノースカロライナ アット チャペル ヒル 乳癌の予後を予測するための遺伝子発現プロフィール
US20100105039A1 (en) * 2008-06-03 2010-04-29 Yi Lu Label-free colorimetric detection
US20110195064A1 (en) * 2008-06-06 2011-08-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv Survival predictor for diffuse large b cell lymphoma
US8255167B2 (en) 2008-08-14 2012-08-28 Regeneron Pharmaceuticals, Inc. Non-hypergeometric overlap probability
WO2010021696A1 (en) 2008-08-18 2010-02-25 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for determining a graft tolerant phenotype in a subject
EP2318552B1 (en) 2008-09-05 2016-11-23 TOMA Biosciences, Inc. Methods for stratifying and annotating cancer drug treatment options
US8968210B2 (en) 2008-10-01 2015-03-03 Covidien LLP Device for needle biopsy with integrated needle protection
US9782565B2 (en) 2008-10-01 2017-10-10 Covidien Lp Endoscopic ultrasound-guided biliary access system
US9186128B2 (en) 2008-10-01 2015-11-17 Covidien Lp Needle biopsy device
US11298113B2 (en) 2008-10-01 2022-04-12 Covidien Lp Device for needle biopsy with integrated needle protection
US9332973B2 (en) 2008-10-01 2016-05-10 Covidien Lp Needle biopsy device with exchangeable needle and integrated needle protection
US8062893B2 (en) 2008-10-10 2011-11-22 The Board Of Trustees Of The University Of Illinois Fluorescent sensor for mercury
JP2012507300A (ja) 2008-10-30 2012-03-29 カリス ライフ サイエンシズ ルクセンブルク ホールディングス Ｒｎａパターンを評価する方法
US20100112643A1 (en) * 2008-11-04 2010-05-06 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Method for direct capture of ribonucleic acid
US9068974B2 (en) 2008-11-08 2015-06-30 The Wistar Institute Of Anatomy And Biology Biomarkers in peripheral blood mononuclear cells for diagnosing or detecting lung cancers
US20100179213A1 (en) * 2008-11-11 2010-07-15 Mirna Therapeutics, Inc. Methods and Compositions Involving miRNAs In Cancer Stem Cells
EP2192197A1 (en) 2008-11-27 2010-06-02 Vereniging voor christelijk hoger onderwijs, wetenschappelijk onderzoek en patiëntenzorg Predicting clinical response to treatment with a soluble tnf-antagonist or tnf, or a tnf receptor agonist
WO2010091328A1 (en) 2009-02-09 2010-08-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Diagnostic and therapeutic uses of gnptab, gnptg, and nagpa in stuttering
WO2010096658A1 (en) 2009-02-19 2010-08-26 The Cleveland Clinic Foundation Corin as a marker for heart failure
AU2010226726B8 (en) 2009-03-16 2014-08-14 Pangu Biopharma Limited Compositions and methods comprising histidyl-tRNA synthetase splice variants having non-canonical biological activities
EP2414513B1 (en) 2009-03-31 2015-10-28 Atyr Pharma, Inc. Compositions and methods comprising aspartyl-trna synthetases having non-canonical biological activities
WO2010138456A2 (en) 2009-05-29 2010-12-02 The Regents Of The University Of California B cell signature associated with tolerance in transplant recipients
CA2767616A1 (en) 2009-07-09 2011-01-13 The Scripps Research Institute Gene expression profiles associated with chronic allograft nephropathy
JP5575239B2 (ja) 2009-07-21 2014-08-20 ジェン−プローブ・インコーポレーテッド 拡張されたダイナミックレンジにわたる核酸配列の定量的検出のための方法および組成物
EP2827150B3 (en) 2009-08-22 2021-08-18 The Board of Trustees of the Leland Stanford Junior University Imaging and evaluating embryos, oocytes, and stem cells
EP2488873B1 (en) 2009-10-16 2015-08-05 Novartis AG Biomarkers of tumor pharmacodynamic response
CN102640001A (zh) 2009-11-05 2012-08-15 诺瓦提斯公司 预测纤维化进展的生物标记物
WO2011068829A1 (en) 2009-12-02 2011-06-09 The Board Of Trustees Of The Leland Stanford Junior University Biomarkers for determining an allograft tolerant phenotype
US8501122B2 (en) 2009-12-08 2013-08-06 Affymetrix, Inc. Manufacturing and processing polymer arrays
US9315857B2 (en) 2009-12-15 2016-04-19 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse label-tags
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
GB0922085D0 (en) 2009-12-17 2010-02-03 Cambridge Entpr Ltd Cancer diagnosis and treatment
US20110152109A1 (en) * 2009-12-21 2011-06-23 Gardner Shea N Biological sample target classification, detection and selection methods, and related arrays and oligonucleotide probes
WO2011079280A2 (en) 2009-12-23 2011-06-30 Hill's Pet Nutrition, Inc. Compositions and methods for diagnosing and treating kidney disorders in a canine
IN2012DN06588A (enExample) 2010-02-10 2015-10-23 Novartis Ag
US20130058915A1 (en) 2010-03-02 2013-03-07 Children's Medica Center Corporation Methods and compositions for treatment of angelman syndrome and autism spectrum disorders
EP3214174B1 (en) 2010-03-04 2019-10-16 InteRNA Technologies B.V. A mirna molecule defined by its source and its diagnostic and therapeutic uses in diseases or conditions associated with emt
JP5197661B2 (ja) * 2010-03-15 2013-05-15 キヤノン株式会社 核酸検出用プローブ担体
US8383793B2 (en) 2010-04-15 2013-02-26 St. Jude Children's Research Hospital Methods and compositions for the diagnosis and treatment of cancer resistant to anaplastic lymphoma kinase (ALK) kinase inhibitors
MX2012012235A (es) 2010-04-19 2012-11-23 Procter & Gamble Firmas geneticas y matrices geneticas asociadas con la administracion de corriente de radio frecuencia conducida electricamente a la piel y metodos y tratamiento relacionados a ellos.
BR112012026871A2 (pt) 2010-04-19 2017-06-06 Procter & Gamble aplicação combinada de composição tópica e de energia para regular a condição de pele de mamíferos
WO2011139714A2 (en) 2010-04-26 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-trna synthetase
US20120003639A1 (en) 2010-04-27 2012-01-05 Prelude, Inc. Cancer biomarkers and methods of use thereof
CN103096911B (zh) 2010-04-27 2018-05-29 Atyr 医药公司 与异亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CA2797271C (en) 2010-04-28 2021-05-25 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl trna synthetases
AU2011246976B2 (en) 2010-04-29 2016-01-28 Allarity Therapeutics Europe ApS Methods and devices for predicting treatment efficacy
AU2011248457B2 (en) 2010-04-29 2017-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl tRNA synthetases
CN103097523B (zh) 2010-04-29 2016-09-28 Atyr医药公司 与天冬酰胺酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
WO2011150279A2 (en) 2010-05-27 2011-12-01 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases
ES2668207T3 (es) 2010-05-03 2018-05-17 Atyr Pharma, Inc. Descubrimiento innovador de composiciones terapéuticas, de diagnóstico y de anticuerpos relacionadas con fragmentos de proteínas de metionil-ARNt sintetasas
EP2566495B1 (en) 2010-05-03 2017-03-01 aTyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-trna synthetases
CA2797277C (en) 2010-05-03 2021-02-23 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases
CA2798139C (en) 2010-05-04 2019-09-24 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-trna synthetase complex
EP2568996B1 (en) 2010-05-14 2017-10-04 aTyr Pharma, Inc. Therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-trna synthetases
CN103096914B (zh) 2010-05-17 2015-08-12 Atyr医药公司 与亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
EP2390346A1 (en) 2010-05-28 2011-11-30 Universiteit Twente Osteoarthrosis markers
AU2011261486B2 (en) 2010-06-01 2017-02-23 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-tRNA synthetases
CA3113343C (en) 2010-06-03 2024-10-08 Pharmacyclics Llc USE OF BRUTON'S TYROSINE KINASE INHIBITORS IN THE TREATMENT OF FOLLICULAR LYMPHOMA
US20120009177A1 (en) 2010-06-07 2012-01-12 Roche Molecular Systems, Inc. Gene expression markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
AU2011274619B2 (en) 2010-07-06 2016-11-10 Interna Technologies Bv miRNA and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated BRAF pathway
AU2011289831C1 (en) 2010-07-12 2017-06-15 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
US8815156B2 (en) 2010-07-19 2014-08-26 Andalyze, Inc. Sensor housing and reagent chemistry
US8862410B2 (en) 2010-08-02 2014-10-14 Population Diagnostics, Inc. Compositions and methods for discovery of causative mutations in genetic disorders
WO2012019099A2 (en) 2010-08-05 2012-02-09 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Follistatin-like-protein-1 as a biomarker for inflammatory disorders
CN112501118A (zh) 2010-08-12 2021-03-16 菲特治疗公司 改进的造血干细胞和祖细胞疗法
DK3109325T3 (en) 2010-08-24 2019-01-28 Dana Farber Cancer Inst Inc Methods for predicting anticancer response
AU2011293294B2 (en) 2010-08-25 2016-03-24 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Tyrosyl-tRNA synthetases
MX344636B (es) 2010-09-15 2017-01-04 Almac Diagnostics Ltd Prueba de diagnóstico molecular para cáncer.
ES2523140T3 (es) 2010-09-21 2014-11-21 Population Genetics Technologies Ltd. Aumento de la confianza en las identificaciones de alelos con el recuento molecular
JP6163104B2 (ja) 2010-11-15 2017-07-12 アクセラレイテッド・バイオサイエンシズ・コーポレーション ヒト・トロホブラスト幹細胞からの神経幹細胞の生成
US10150999B2 (en) 2010-11-17 2018-12-11 Interpace Diagnostics, Llc miRNAs as biomarkers for distinguishing benign from malignant thyroid neoplasms
CA2819538A1 (en) 2010-11-30 2012-06-07 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg Method for prognosticating the clinical response of a patient to b-lymphocyte inhibiting or depleting therapy in interferon driven diseases such as sle.
CA2819378A1 (en) 2010-12-02 2012-06-07 Katholieke Universiteit Leuven, K.U.Leuven R&D Irak-related interventions and diagnosis
EP2474617A1 (en) 2011-01-11 2012-07-11 InteRNA Technologies BV Mir for treating neo-angiogenesis
CN103460038A (zh) 2011-02-23 2013-12-18 里兰斯坦福初级大学理事会 检测人类胚胎中的非整倍性的方法
RU2564122C2 (ru) 2011-02-24 2015-09-27 Хилл'С Пет Ньютришн, Инк. Способ и набор для диагностики гломерулонефрита у кошки
EP2681566A2 (en) 2011-02-28 2014-01-08 University of Iowa Research Foundation Anti-müllerian hormone changes in pregnancy and prediction ofadverse pregnancy outcomes and gender
JP2014508165A (ja) 2011-03-02 2014-04-03 モルフォテック、インク． 乳癌の治療のためのエリブリンおよびファーレツズマブの共投与
JP6105491B2 (ja) 2011-03-02 2017-03-29 バーグ エルエルシー 照合性細胞ベースのアッセイ及びその使用
AU2012229123B2 (en) 2011-03-15 2017-02-02 British Columbia Cancer Agency Branch Methods of treating breast cancer with anthracycline therapy
US10184942B2 (en) 2011-03-17 2019-01-22 University Of South Florida Natriuretic peptide receptor as a biomarker for diagnosis and prognosis of cancer
WO2012129100A1 (en) 2011-03-18 2012-09-27 Eisai R&D Management Co., Ltd. Methods and compositions for predicting response to eribulin
US20140005070A1 (en) 2011-03-28 2014-01-02 Novartis Ag Markers associated with cyclin-dependent kinase inhibitors
WO2012134813A1 (en) 2011-03-31 2012-10-04 St. Jude Children's Research Hospital Methods and compositions for identifying minimal residual disease in acute lymphoblastic leukemia
WO2012163541A1 (en) 2011-06-01 2012-12-06 Medical Prognosis Institute A/S Methods and devices for prognosis of cancer relapse
SG195208A1 (en) 2011-06-02 2013-12-30 Almac Diagnostics Ltd Molecular diagnostic test for cancer
CN103597097B (zh) 2011-06-15 2016-08-17 希尔氏宠物营养品公司 用于诊断和监测猫科动物的甲状腺功能亢进的组合物和方法
EP4563709A3 (en) 2011-06-17 2025-09-03 Myriad Genetics, Inc. Methods and materials for assessing allelic imbalance
WO2012177906A1 (en) 2011-06-21 2012-12-27 Alnylam Pharmaceuticals, Inc. Assays and methods for determining activity of a therapeutic agent in a subject
AU2012275841A1 (en) 2011-06-27 2014-01-16 The Jackson Laboratory Methods and compositions for treatment of cancer and autoimmune disease
US9644241B2 (en) 2011-09-13 2017-05-09 Interpace Diagnostics, Llc Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease
DK2766483T3 (da) 2011-10-10 2022-04-19 Hospital For Sick Children Fremgangsmåder og sammensætninger til screening for og behandling af udviklingsforstyrrelser
JP5873183B2 (ja) 2011-10-18 2016-03-01 ルミネックス コーポレーション 画像データ処理方法及びシステム
WO2013063519A1 (en) 2011-10-26 2013-05-02 Asuragen, Inc. Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts
US20130142728A1 (en) 2011-10-27 2013-06-06 Asuragen, Inc. Mirnas as diagnostic biomarkers to distinguish benign from malignant thyroid tumors
WO2013067448A2 (en) 2011-11-03 2013-05-10 Vca Antech Inc. Compositions and methods to detect various infectious organisms
WO2013067451A2 (en) 2011-11-04 2013-05-10 Population Diagnostics Inc. Methods and compositions for diagnosing, prognosing, and treating neurological conditions
WO2013075065A1 (en) 2011-11-18 2013-05-23 Memorial Sloan-Kettering Cancer Center 2-hydroxyglutarate as a biomarker for chronic hypoxia
US20140017174A1 (en) 2011-11-30 2014-01-16 Raja Atreya Methods and compositions for determining responsiveness to treatment with a tnf-alpha inhibitor
US8748097B1 (en) 2011-12-02 2014-06-10 President And Fellows Of Harvard College Identification of agents for treating calcium disorders and uses thereof
WO2013087789A1 (en) 2011-12-13 2013-06-20 Glykos Finland Ltd. Antibody isoform arrays and methods thereof
CA2859021A1 (en) 2011-12-19 2013-06-27 Valley Health System Methods and kits for detecting subjects at risk of having cancer
AU2012355775B2 (en) 2011-12-19 2015-10-08 Hill's Pet Nutrition, Inc. Compositions and methods for diagnosing and treating hyperthyroidism in companion animals
EP4497824A3 (en) 2011-12-21 2025-04-16 Myriad Genetics, Inc. Methods and materials for assessing loss of heterozygosity
CA3191015A1 (en) 2012-02-07 2013-08-15 Vibrant Holdings, Llc Substrates, peptide arrays, and methods
US10407724B2 (en) 2012-02-09 2019-09-10 The Hospital For Sick Children Methods and compositions for screening and treating developmental disorders
IN2014MN01642A (enExample) 2012-02-16 2015-07-03 Atyr Pharma Inc
CA3095010A1 (en) 2012-02-21 2013-08-29 Cytonics Corporation Systems, compositions, and methods for transplantation
CA3080441C (en) 2012-02-23 2026-01-06 The Technical University Of Denmark Methods for predicting anti-cancer response
ES2663234T3 (es) 2012-02-27 2018-04-11 Cellular Research, Inc Composiciones y kits para recuento molecular
ES2776673T3 (es) 2012-02-27 2020-07-31 Univ North Carolina Chapel Hill Métodos y usos para etiquetas moleculares
US9670529B2 (en) 2012-02-28 2017-06-06 Population Genetics Technologies Ltd. Method for attaching a counter sequence to a nucleic acid sample
US10061887B2 (en) 2012-04-02 2018-08-28 Berg Llc Interrogatory cell-based assays and uses thereof
WO2013152307A1 (en) 2012-04-05 2013-10-10 The Regents Of The University Of California Gene expression panel for breast cancer prognosis
WO2013177245A2 (en) 2012-05-22 2013-11-28 Nanostring Technologies, Inc. Nano46 genes and methods to predict breast cancer outcome
CA3126823C (en) 2012-06-07 2023-04-04 Institut Curie Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors
EP3339861B8 (en) 2012-06-15 2023-11-01 Genesis Theranostix Korlatolt Felelossegu Tarsasag Biomarker test for prediction or early detection of preeclampsia
US10670610B2 (en) 2012-06-15 2020-06-02 Wayne State University Biomarker test for prediction or early detection of preeclampsia and/or HELLP syndrome
EP2870263A1 (en) 2012-07-03 2015-05-13 InteRNA Technologies B.V. Diagnostic portfolio and its uses
ES2776365T3 (es) 2012-07-09 2020-07-30 Novartis Ag Biomarcadores asociados con inhibidores de CDK
CA2879427A1 (en) 2012-07-20 2014-01-23 La Trobe University Method of diagnosis and treatment
US10954567B2 (en) 2012-07-24 2021-03-23 Pharmacyclics Llc Mutations associated with resistance to inhibitors of Bruton's Tyrosine Kinase (BTK)
ES2742285T3 (es) 2012-07-31 2020-02-13 Novartis Ag Marcadores asociados con la sensibilidad a inhibidores del doble minuto humano 2 (MDM2)
EP4218935A1 (en) 2012-08-13 2023-08-02 The Rockefeller University Lxrbeta agonist for the treatment of cancer
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
DE202013012824U1 (de) 2012-09-04 2020-03-10 Guardant Health, Inc. Systeme zum Erfassen von seltenen Mutationen und einer Kopienzahlvariation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
EP2895621B1 (en) 2012-09-14 2020-10-21 Population Bio, Inc. Methods and compositions for diagnosing, prognosing, and treating neurological conditions
WO2014052855A1 (en) 2012-09-27 2014-04-03 Population Diagnostics, Inc. Methods and compositions for screening and treating developmental disorders
US10006909B2 (en) 2012-09-28 2018-06-26 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
US20140100124A1 (en) 2012-10-04 2014-04-10 Asuragen, Inc. Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions
US20150354006A1 (en) 2012-10-19 2015-12-10 Novartis Ag Markers for acute lymphoblastic leukemia
CN109793897B (zh) 2012-10-31 2022-02-01 洛克菲勒大学 结肠癌的治疗和诊断
US10286376B2 (en) 2012-11-14 2019-05-14 Vibrant Holdings, Llc Substrates, systems, and methods for array synthesis and biomolecular analysis
CA2892822C (en) 2012-11-27 2023-08-08 Pontificia Universidad Catolica De Chile Compositions and methods for diagnosing thyroid tumors
CA2891542C (en) 2012-11-30 2021-12-14 Accelerated Biosciences Corp. Pancreatic progenitor cells expressing betatrophin and insulin
WO2014087156A1 (en) 2012-12-03 2014-06-12 Almac Diagnostics Limited Molecular diagnostic test for cancer
EP2946214A1 (en) 2013-01-21 2015-11-25 AbbVie Inc. Anti-tnf and anti-il17 combination therapy biomarkers for inflammatory disease
CA2923379C (en) 2013-02-15 2023-01-03 Vibrant Holdings, Llc Methods and compositions for amplified electrochemiluminescence detection
AU2014223824B2 (en) 2013-02-28 2020-02-27 Albert Einstein College Of Medicine, Inc. Tuberculosis biomarkers and uses thereof
TWI582239B (zh) 2013-03-11 2017-05-11 諾華公司 與ｗｎｔ抑制劑相關之標記
US10308986B2 (en) 2013-03-14 2019-06-04 Children's Medical Center Corporation Cancer diagnosis, treatment selection and treatment
WO2014159242A1 (en) 2013-03-14 2014-10-02 Novartis Ag Notch 3 mutants and uses thereof
EP3611189A1 (en) 2013-03-14 2020-02-19 Novartis AG Antibodies against notch 3
US9868992B2 (en) 2013-03-15 2018-01-16 Baylor Research Institute Tissue and blood-based miRNA biomarkers for the diagnosis, prognosis and metastasis-predictive potential in colorectal cancer
EP3404116B1 (en) 2013-03-15 2022-10-19 The University of Chicago Methods and compositions related to t-cell activity
EP3366785A3 (en) 2013-03-15 2018-09-19 Baylor Research Institute Ulcerative colitis (uc)-associated colorectal neoplasia markers
US20160091485A1 (en) 2013-04-25 2016-03-31 The Broad Institute, Inc. Markers for ezh2 inhibitors
WO2014195032A1 (en) 2013-06-07 2014-12-11 Medical Prognosis Institute A/S Methods and devices for predicting treatment efficacy of fulvestrant in cancer patients
JP6656733B2 (ja) 2013-08-05 2020-03-04 ツイスト バイオサイエンス コーポレーション 新規合成した遺伝子ライブラリ
CA2922806A1 (en) 2013-08-28 2015-03-05 Cytonics Corporation Systems, compositions, and methods for transplantation and treating conditions utilizing a composition comprising a wild-type or a variant a2m polypeptide or portion thereof
EP3480321B8 (en) 2013-08-28 2021-03-10 Becton, Dickinson and Company Massively parallel single cell analysis
JP2016537010A (ja) 2013-09-09 2016-12-01 ブリティッシュ コロンビア キャンサー エージェンシー ブランチ 予後を予測するための方法及びキット、並びに、放射線照射療法を用いた乳癌の治療方法及びキット
AU2014329547B2 (en) 2013-10-02 2019-05-16 The Board Of Trustees Of The Leland Stanford Junior University Wnt compositions and methods for purification
CN105745528A (zh) 2013-10-07 2016-07-06 赛卢拉研究公司 用于以数字方式对阵列上的特征进行计数的方法和系统
CA2929826C (en) 2013-11-06 2022-08-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Method for selecting and treating lymphoma types
FI3511422T3 (fi) 2013-11-12 2023-01-31 Menetelmiä ja koostumuksia endometriooosin diagnosointia, ennustamista ja hoitoa varten
CA2931181C (en) 2013-12-09 2023-01-24 Institut Curie Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors
SG10201804519RA (en) 2013-12-28 2018-07-30 Guardant Health Inc Methods and systems for detecting genetic variants
WO2015120130A1 (en) 2014-02-07 2015-08-13 Novartis Ag Impact of genetic factors on disease progression and response to anti-c5 antibody in geographic atrophy
GB201409479D0 (en) 2014-05-28 2014-07-09 Almac Diagnostics Ltd Molecular diagnostic test for cancer
DK3110973T3 (da) 2014-02-27 2019-05-13 Univ Leuven Kath Oxidativt stress og kardiovaskulære sygdomshændelser
AU2015222944A1 (en) 2014-02-27 2016-09-08 Massachusetts Institute Of Technology T cell balance gene expression, compositions of matters and methods of use thereof
US10704097B2 (en) 2014-02-27 2020-07-07 Katholieke Universiteit Leuven Oxidative stress and cardiovascular disease events
JP2017509336A (ja) 2014-03-20 2017-04-06 ファーマサイクリックス エルエルシー ホスホリパーゼｃガンマ２及び耐性に関連した変異
EP3129510A4 (en) * 2014-04-10 2017-08-30 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Prognostic kits, arrays compositions and methods for predicting interferon treatment efficacy in a subject
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
EP3146077A4 (en) 2014-05-22 2018-05-02 The Scripps Research Institute Tissue molecular signatures of kidney transplant rejections
WO2015179777A2 (en) 2014-05-22 2015-11-26 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
EP3825418A3 (en) 2014-05-22 2021-09-15 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
US10829819B2 (en) 2014-05-30 2020-11-10 Genecentric Therapeutics, Inc. Methods for typing of lung cancer
WO2015187612A1 (en) 2014-06-02 2015-12-10 Valley Health System Method and systems for lung cancer diagnosis
US20160000936A1 (en) 2014-06-10 2016-01-07 Abbvie Inc. Biomarkers for inflammatory disease and methods of using same
EP3169815B1 (en) 2014-07-15 2020-12-23 Ontario Institute For Cancer Research Methods and devices for predicting anthracycline treatment efficacy
US20180363070A9 (en) 2014-08-12 2018-12-20 Univ Wayne State Systems and methods to detect stem cell stress and uses thereof
DK4234711T3 (da) 2014-08-15 2025-08-25 Myriad Genetics Inc Fremgangsmåder og materialer til vurdering af mangel på homolog rekombination
WO2016036403A1 (en) 2014-09-05 2016-03-10 Population Diagnostics Inc. Methods and compositions for inhibiting and treating neurological conditions
WO2016038550A1 (en) 2014-09-11 2016-03-17 Novartis Ag Inhibition of prmt5 to treat mtap-deficiency-related diseases
EP3224381B1 (en) 2014-11-25 2019-09-04 The Brigham and Women's Hospital, Inc. Method of identifying a person having a predisposition to or afflicted with a cardiometabolic disease
WO2016085876A1 (en) 2014-11-25 2016-06-02 The Broad Institute Inc. Clonal haematopoiesis
EP3224347A4 (en) 2014-11-26 2018-08-15 Accelerated BioSciences Corp. Induced hepatocytes and uses thereof
EP3227446A1 (en) 2014-12-01 2017-10-11 Novartis AG Compositions and methods for diagnosis and treatment of prostate cancer
WO2016090323A1 (en) 2014-12-05 2016-06-09 Prelude, Inc. Dcis recurrence and invasive breast cancer
SG10202012249YA (en) 2014-12-08 2021-01-28 Berg Llc Use of markers including filamin a in the diagnosis and treatment of prostate cancer
ES2748005T3 (es) 2014-12-12 2020-03-12 Medivation Prostate Therapeutics Llc Método para predecir la respuesta a agentes terapéuticos de cáncer de mama y método de tratamiento de cáncer de mama
TW201702218A (zh) 2014-12-12 2017-01-16 美國杰克森實驗室 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法
DK3234112T3 (da) 2014-12-19 2020-03-02 Univ Brussel Vrije In vitro-modning af et pattedyre-cumulus-oocytkompleks
US10669304B2 (en) 2015-02-04 2020-06-02 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
CA2975855C (en) 2015-02-04 2025-09-23 Twist Bioscience Corporation SYNTHETIC GENE COMPOSITIONS AND ASSEMBLY METHODS
US10697010B2 (en) 2015-02-19 2020-06-30 Becton, Dickinson And Company High-throughput single-cell analysis combining proteomic and genomic information
EP3262193A2 (en) 2015-02-26 2018-01-03 The Broad Institute Inc. T cell balance gene expression, compositions of matters and methods of use thereof
ES2836802T3 (es) 2015-02-27 2021-06-28 Becton Dickinson Co Códigos de barras moleculares espacialmente direccionables
EP4180535A1 (en) 2015-03-30 2023-05-17 Becton, Dickinson and Company Methods and compositions for combinatorial barcoding
WO2016172377A1 (en) 2015-04-21 2016-10-27 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
CN107580632B (zh) 2015-04-23 2021-12-28 贝克顿迪金森公司 用于全转录组扩增的方法和组合物
US11124823B2 (en) 2015-06-01 2021-09-21 Becton, Dickinson And Company Methods for RNA quantification
GB201512869D0 (en) 2015-07-21 2015-09-02 Almac Diagnostics Ltd Gene signature for minute therapies
JP6923509B2 (ja) 2015-07-28 2021-08-18 オトノミ—，インク． 切断型のｔｒｋｂおよびｔｒｋｃのアンタゴニストを使用する処置
WO2017044574A1 (en) 2015-09-11 2017-03-16 Cellular Research, Inc. Methods and compositions for nucleic acid library normalization
US10844373B2 (en) 2015-09-18 2020-11-24 Twist Bioscience Corporation Oligonucleic acid variant libraries and synthesis thereof
CN108698012A (zh) 2015-09-22 2018-10-23 特韦斯特生物科学公司 用于核酸合成的柔性基底
EP3901279B1 (en) 2015-10-18 2023-05-17 Affymetrix, Inc. Multiallelic genotyping of single nucleotide polymorphisms and indels
EP3384077A4 (en) 2015-12-01 2019-05-08 Twist Bioscience Corporation FUNCTIONALIZED SURFACES AND MANUFACTURE THEREOF
JP2019507585A (ja) 2015-12-17 2019-03-22 ガーダント ヘルス， インコーポレイテッド 無細胞ｄｎａの分析による腫瘍遺伝子コピー数を決定するための方法
US11828759B2 (en) 2016-02-11 2023-11-28 Peter Maccallum Cancer Institute Method of diagnosis
US10472666B2 (en) 2016-02-15 2019-11-12 Roche Sequencing Solutions, Inc. System and method for targeted depletion of nucleic acids
WO2017140659A1 (en) 2016-02-15 2017-08-24 F. Hoffmann-La Roche Ag System and method for targeted depletion of nucleic acids
CN116509869A (zh) 2016-04-04 2023-08-01 希诺皮亚生物科学公司 使用曲匹地尔治疗锥体外系综合征
EP3446123A4 (en) 2016-04-20 2019-11-06 LDX Prognostics Limited Co. METHOD AND COMPOSITIONS FOR THE FORECAST OF A BREAKFAST
EP3445873B1 (en) 2016-04-20 2020-11-04 The United States of America, as represented by The Secretary, Department of Health and Human Services Evaluation of mantle cell lymphoma and methods related thereto
WO2017192387A1 (en) 2016-05-02 2017-11-09 Cellular Research, Inc. Accurate molecular barcoding
CN109790583B (zh) 2016-05-17 2023-08-25 基因中心治疗公司 对肺腺癌亚型分型的方法
WO2017197573A1 (en) 2016-05-17 2017-11-23 Ldx Prognostics Limited Co. Methods and compositions for providing preeclampsia assessment
WO2017201164A1 (en) 2016-05-17 2017-11-23 Genecentric Diagnostics, Inc. Methods for subtyping of lung squamous cell carcinoma
US10301677B2 (en) 2016-05-25 2019-05-28 Cellular Research, Inc. Normalization of nucleic acid libraries
US11397882B2 (en) 2016-05-26 2022-07-26 Becton, Dickinson And Company Molecular label counting adjustment methods
US10640763B2 (en) 2016-05-31 2020-05-05 Cellular Research, Inc. Molecular indexing of internal sequences
US10202641B2 (en) 2016-05-31 2019-02-12 Cellular Research, Inc. Error correction in amplification of samples
EP3260552A1 (en) 2016-06-20 2017-12-27 Istituto Europeo di Oncologia (IEO) Methods and kits comprising gene signatures for stratifying breast cancer patients
WO2018013883A1 (en) 2016-07-14 2018-01-18 Caprion Proteomics Inc. Biomarkers of latent tuberculosis infection
CN109996876A (zh) 2016-08-22 2019-07-09 特韦斯特生物科学公司 从头合成的核酸文库
KR102217487B1 (ko) 2016-09-21 2021-02-23 트위스트 바이오사이언스 코포레이션 핵산 기반 데이터 저장
EP3516400B1 (en) 2016-09-26 2023-08-16 Becton, Dickinson and Company Measurement of protein expression using reagents with barcoded oligonucleotide sequences
US11725232B2 (en) 2016-10-31 2023-08-15 The Hong Kong University Of Science And Technology Compositions, methods and kits for detection of genetic variants for alzheimer's disease
EP4628595A3 (en) 2016-11-08 2025-11-05 Becton, Dickinson and Company Methods for cell label classification
CN109952612B (zh) 2016-11-08 2023-12-01 贝克顿迪金森公司 用于表达谱分类的方法
JP7169975B2 (ja) 2016-12-16 2022-11-11 ツイスト バイオサイエンス コーポレーション 免疫シナプスの変異体ライブラリーおよびその合成
EP3559262B1 (en) 2016-12-22 2025-04-09 Illumina, Inc. Arrays with quality control tracers
ES2961580T3 (es) 2017-01-13 2024-03-12 Cellular Res Inc Revestimiento hidrófilo de canales de fluidos
US11319583B2 (en) 2017-02-01 2022-05-03 Becton, Dickinson And Company Selective amplification using blocking oligonucleotides
US10240205B2 (en) 2017-02-03 2019-03-26 Population Bio, Inc. Methods for assessing risk of developing a viral disease using a genetic test
EP4556433A3 (en) 2017-02-22 2025-08-06 Twist Bioscience Corporation Nucleic acid based data storage
US11179413B2 (en) 2017-03-06 2021-11-23 Novartis Ag Methods of treatment of cancer with reduced UBB expression
US10894959B2 (en) 2017-03-15 2021-01-19 Twist Bioscience Corporation Variant libraries of the immunological synapse and synthesis thereof
EP3615694B1 (en) 2017-04-25 2022-03-30 The Brigham and Women's Hospital, Inc. Il-8, il-6, il-1b and tet2 and dnmt3a in atherosclerosis
WO2018218250A2 (en) 2017-05-26 2018-11-29 Vibrant Holdings, Llc Photoactive compounds and methods for biomolecule detection and sequencing
CN110719959B (zh) 2017-06-05 2021-08-06 贝克顿迪金森公司 针对单细胞的样品索引
WO2018231864A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
KR102784398B1 (ko) 2017-06-12 2025-03-19 트위스트 바이오사이언스 코포레이션 심리스 핵산 어셈블리를 위한 방법
EP3638814B8 (en) 2017-06-14 2023-06-21 The United States of America, as Represented by The Secretary, Department of Health and Human Services Method for determining lymphoma type
EP3655418A4 (en) 2017-06-22 2021-05-19 Triact Therapeutics, Inc. GLIOBLASTOMA TREATMENT METHODS
WO2019018764A1 (en) 2017-07-21 2019-01-24 Genecentric Therapeutics, Inc. METHODS OF DETERMINING RESPONSE TO PARP INHIBITORS
EP4085919A3 (en) 2017-07-21 2023-02-08 Novartis AG Compositions and methods to treat cancer
EP3665199A4 (en) 2017-08-07 2021-08-11 Genecentric Therapeutics, Inc. METHOD OF SUBTYPING PLATE EPITHELIAL CARCINOMA OF THE HEAD AND NECK
WO2019030718A1 (en) * 2017-08-11 2019-02-14 Glaxosmithkline Biologicals Sa RNA IDENTIFICATION METHOD USING H RNA DIGESTION AND SIZE FRACTIONATION
CN111542521B (zh) 2017-09-11 2024-02-23 赛泰尔治疗公司 Rad51抑制剂
US11407837B2 (en) 2017-09-11 2022-08-09 Twist Bioscience Corporation GPCR binding proteins and synthesis thereof
WO2019067991A1 (en) 2017-09-29 2019-04-04 Triact Therapeutics, Inc. INIPARIB FORMULATIONS AND USES THEREOF
GB2583590A (en) 2017-10-20 2020-11-04 Twist Bioscience Corp Heated nanowells for polynucleotide synthesis
EP3704250A1 (en) 2017-11-03 2020-09-09 InteRNA Technologies B.V. Mirna molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation
AU2018373028A1 (en) 2017-11-21 2020-04-30 Inspirna, Inc. Polymorphs and uses thereof
US12276654B2 (en) 2017-11-22 2025-04-15 The University Of Chicago Chemical probe-dependent evaluation of protein activity and uses thereof
JP6995604B2 (ja) * 2017-12-15 2022-01-14 東洋鋼鈑株式会社 一塩基多型検出用プローブの設計方法及びプローブセット
CN111492068B (zh) 2017-12-19 2025-03-21 贝克顿迪金森公司 与寡核苷酸相关联的颗粒
KR20250069684A (ko) 2018-01-04 2025-05-19 트위스트 바이오사이언스 코포레이션 Dna 기반 디지털 정보 저장
WO2019160914A1 (en) 2018-02-13 2019-08-22 Genecentric Therapeutics, Inc. Methods for subtyping of bladder cancer
ES2960914T3 (es) 2018-03-16 2024-03-07 Gopath Laboratories Llc Métodos para la detección personalizada de la reaparición del cáncer o de la metástasis y/o evaluación de la respuesta al tratamiento
US11957695B2 (en) 2018-04-26 2024-04-16 The Broad Institute, Inc. Methods and compositions targeting glucocorticoid signaling for modulating immune responses
EP3788138A1 (en) 2018-05-02 2021-03-10 Novartis AG Regulators of human pluripotent stem cells and uses thereof
AU2019262048B2 (en) 2018-05-03 2025-09-04 Becton, Dickinson And Company High throughput multiomics sample analysis
WO2019213237A1 (en) 2018-05-03 2019-11-07 Becton, Dickinson And Company Molecular barcoding on opposite transcript ends
US20210386829A1 (en) 2018-05-04 2021-12-16 The Broad Institute, Inc. Compositions and methods for modulating cgrp signaling to regulate innate lymphoid cell inflammatory responses
EP3790985A4 (en) 2018-05-09 2022-02-16 Vibrant Holdings, LLC METHOD OF SYNTHESIS OF A POLYNUCLEOTIDARRAY USING PHOTOACTIVATED AGENTS
JP2021526366A (ja) 2018-05-18 2021-10-07 ツイスト バイオサイエンス コーポレーション 核酸ハイブリダイゼーションのためのポリヌクレオチド、試薬、および方法
CN121041959A (zh) 2018-05-29 2025-12-02 生捷科技控股公司 在基材提高光化学反应的效率
FI3625368T3 (fi) 2018-08-08 2023-01-13 Menetelmiä john cunningham -viruksen aiheuttaman progressiivin multifokaalin leukoenkefalopatian kehittymisen riskin arviointiin geneettisellä testauksella
WO2020036926A1 (en) 2018-08-17 2020-02-20 Cellecta, Inc. Multiplex preparation of barcoded gene specific dna fragments
WO2020049106A1 (en) 2018-09-05 2020-03-12 Max-Delbrück-Centrum Für Molekulare Medizin In Der Helmholtz-Gemeinschaft A method for engineering synthetic cis-regulatory dna
CA3112792A1 (en) 2018-09-14 2020-03-19 Prelude Corporation Method of selection for treatment of subjects at risk of invasive breast cancer
WO2020072380A1 (en) 2018-10-01 2020-04-09 Cellular Research, Inc. Determining 5' transcript sequences
US20210388449A1 (en) 2018-10-09 2021-12-16 Genecentric Therapeutics, Inc. Detecting cancer cell of origin
WO2020077135A1 (en) 2018-10-10 2020-04-16 Dana-Farber Cancer Institute, Inc. Modulating resistance to bcl-2 inhibitors
EP3877520B1 (en) 2018-11-08 2025-03-19 Becton, Dickson And Company Whole transcriptome analysis of single cells using random priming
US12402610B2 (en) 2018-11-09 2025-09-02 The Broad Institute, Inc. Methods and compositions for modulating innate lymphoid cell pathogenic effectors
WO2020104482A1 (en) 2018-11-20 2020-05-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting metastatic potential in patients suffering from sdhb-mutated paraganglioma
EP3660172A1 (en) 2018-11-28 2020-06-03 Bioscreening and Diagnostics LLC Method for detection of traumatic brain injury (tbi)
US11492660B2 (en) 2018-12-13 2022-11-08 Becton, Dickinson And Company Selective extension in single cell whole transcriptome analysis
EA202191741A1 (ru) 2018-12-20 2021-10-25 Ауранса Инк. Аналоги пентамидина и их применение
CA3114754A1 (en) 2018-12-21 2020-06-25 Scott Kuersten Nuclease-based rna depletion
EP3902816A4 (en) 2018-12-26 2022-09-14 Twist Bioscience Corporation HIGHLY ACCURATE POLYNUCLEOTIDE DE NOVO SYNTHESIS
EP3908668A4 (en) 2019-01-11 2022-11-09 University of Virginia Patent Foundation COMPOSITIONS AND METHODS FOR PREDICTING LUNG FUNCTION DECLINE RELATED TO IDIOPATHIC PULMONARY FIBROSIS
US11371076B2 (en) 2019-01-16 2022-06-28 Becton, Dickinson And Company Polymerase chain reaction normalization through primer titration
US11661631B2 (en) 2019-01-23 2023-05-30 Becton, Dickinson And Company Oligonucleotides associated with antibodies
EP3924506A1 (en) 2019-02-14 2021-12-22 Becton Dickinson and Company Hybrid targeted and whole transcriptome amplification
CN113785057A (zh) 2019-02-26 2021-12-10 特韦斯特生物科学公司 用于抗体优化的变异核酸文库
EP3930753A4 (en) 2019-02-26 2023-03-29 Twist Bioscience Corporation VARIANT NUCLEIC ACID LIBRARIES FOR GLP1 RECEPTOR
AU2020228047B2 (en) 2019-02-27 2025-11-20 Madera Therapeutics, LLC Use of caseinolytic protease P function as a biomarker of drug response to imipridone-like agents
WO2020186101A1 (en) 2019-03-12 2020-09-17 The Broad Institute, Inc. Detection means, compositions and methods for modulating synovial sarcoma cells
JP7460649B2 (ja) 2019-03-12 2024-04-02 サイティアー セラピューティクス，インコーポレイティド Ｒａｄ５１インヒビター
EP3937969A1 (en) 2019-03-14 2022-01-19 The Broad Institute, Inc. Compositions and methods for modulating cgrp signaling to regulate intestinal innate lymphoid cells
EP3942023A1 (en) 2019-03-18 2022-01-26 The Broad Institute, Inc. Compositions and methods for modulating metabolic regulators of t cell pathogenicity
WO2020191069A1 (en) 2019-03-18 2020-09-24 The Broad Institute, Inc. Modulation of type 2 immunity by targeting clec-2 signaling
PH12021552205A1 (en) 2019-03-25 2022-06-13 Cyteir Therapeutics Inc Combinations of rad51 and parp inhibitors
CN114174532A (zh) 2019-04-05 2022-03-11 德克萨斯大学系统董事会 细胞条形码编码的方法和应用
WO2020210521A2 (en) 2019-04-12 2020-10-15 The Regents Of The University Of California Compositions and methods for increasing muscle mass and oxidative metabolism
US11965208B2 (en) 2019-04-19 2024-04-23 Becton, Dickinson And Company Methods of associating phenotypical data and single cell sequencing data
CN114127312B (zh) 2019-04-30 2025-11-21 拉利玛生物医药公司 用于测定共济蛋白替代疗法的疗效的共济蛋白敏感性标志物
RU2709815C1 (ru) * 2019-05-14 2019-12-23 Федеральное бюджетное учреждение науки "Нижегородский научно-исследовательский институт эпидемиологии и микробиологии им. академика И.Н. Блохиной" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека Способ поиска молекулярных маркеров патологического процесса для дифференциальной диагностики, мониторинга и таргетной терапии
US11332738B2 (en) 2019-06-21 2022-05-17 Twist Bioscience Corporation Barcode-based nucleic acid sequence assembly
JP7628090B2 (ja) 2019-06-21 2025-02-07 サイティアー セラピューティクス，インコーポレイティド 膵臓がんの治療にｒａｄ５１阻害剤を利用する方法
CN114051534B (zh) 2019-07-22 2025-02-21 贝克顿迪金森公司 单细胞染色质免疫沉淀测序测定
WO2021030627A1 (en) 2019-08-13 2021-02-18 The General Hospital Corporation Methods for predicting outcomes of checkpoint inhibition and treatment thereof
US12421557B2 (en) 2019-08-16 2025-09-23 The Broad Institute, Inc. Methods for predicting outcomes and treating colorectal cancer using a cell atlas
EP4464827A3 (en) 2019-09-23 2025-02-26 Twist Bioscience Corporation Variant nucleic acid libraries for crth2
US12173282B2 (en) 2019-09-23 2024-12-24 Twist Bioscience, Inc. Antibodies that bind CD3 epsilon
US12195725B2 (en) 2019-10-03 2025-01-14 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating and detecting tissue specific TH17 cell pathogenicity
US11981922B2 (en) 2019-10-03 2024-05-14 Dana-Farber Cancer Institute, Inc. Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment
US11793787B2 (en) 2019-10-07 2023-10-24 The Broad Institute, Inc. Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis
US12018279B2 (en) 2019-10-18 2024-06-25 The Trustees Of The University Of Pennsylvania Micro-engineered models of the human eye and methods of use
US11844800B2 (en) 2019-10-30 2023-12-19 Massachusetts Institute Of Technology Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia
US11773436B2 (en) 2019-11-08 2023-10-03 Becton, Dickinson And Company Using random priming to obtain full-length V(D)J information for immune repertoire sequencing
EP4073025B1 (en) 2019-12-13 2024-03-27 Inspirna, Inc. Metal salts and uses thereof
WO2021127610A1 (en) 2019-12-20 2021-06-24 EDWARD Via COLLEGE OF OSTEOPATHIC MEDICINE Cancer signatures, methods of generating cancer signatures, and uses thereof
US11649497B2 (en) 2020-01-13 2023-05-16 Becton, Dickinson And Company Methods and compositions for quantitation of proteins and RNA
US12165747B2 (en) 2020-01-23 2024-12-10 The Broad Institute, Inc. Molecular spatial mapping of metastatic tumor microenvironment
US12188010B2 (en) 2020-01-29 2025-01-07 Becton, Dickinson And Company Barcoded wells for spatial mapping of single cells through sequencing
EP4111168A1 (en) 2020-02-25 2023-01-04 Becton Dickinson and Company Bi-specific probes to enable the use of single-cell samples as single color compensation control
EP4114389A1 (en) 2020-03-03 2023-01-11 Cyteir Therapeutics, Inc. The rad51 inhibitor compound 67a (2301085-06-1) at a specific dosage for treating cancer
WO2021188611A1 (en) 2020-03-18 2021-09-23 Alnylam Pharmaceuticals, Inc. Compositions and methods for treating subjects having a heterozygous alanine-glyoxylate aminotransferase gene (agxt) variant
CN115916180A (zh) 2020-03-26 2023-04-04 希诺皮亚生物科学公司 同位素标记的曲匹地尔衍生物
EP3907301A1 (en) 2020-05-08 2021-11-10 Istituto Europeo di Oncologia S.r.l. Methods and kits for determining the risk of breast cancer recurrence
CN115605614A (zh) 2020-05-14 2023-01-13 贝克顿迪金森公司（Us） 用于免疫组库谱分析的引物
EP4158055B1 (en) 2020-06-02 2024-03-27 Becton, Dickinson and Company Oligonucleotides and beads for 5 prime gene expression assay
US11932901B2 (en) 2020-07-13 2024-03-19 Becton, Dickinson And Company Target enrichment using nucleic acid probes for scRNAseq
US12391940B2 (en) 2020-07-31 2025-08-19 Becton, Dickinson And Company Single cell assay for transposase-accessible chromatin
JP2023537053A (ja) 2020-08-07 2023-08-30 ザ・ブロード・インスティテュート・インコーポレイテッド Ｘｐｒ１：ｋｉｄｉｎｓ２２０タンパク質複合体を介したがんにおけるリン酸塩調節不全の治療的標的化
WO2022047359A1 (en) 2020-08-31 2022-03-03 Berg Llc Protein biomarkers for pancreatic cancer
US11739443B2 (en) 2020-11-20 2023-08-29 Becton, Dickinson And Company Profiling of highly expressed and lowly expressed proteins
CN116685850A (zh) 2020-12-15 2023-09-01 贝克顿迪金森公司 单细胞分泌组分析
US20240150453A1 (en) 2021-03-09 2024-05-09 Massachusetts Institute Of Technology Methods of predicting response to anti-tnf blockade in inflammatory bowel disease
US12467917B2 (en) 2021-03-16 2025-11-11 California Institute Of Technology Reconstructing human early embryogenesis in vitro with pluripotent stem cells
CA3214821A1 (en) 2021-04-06 2022-10-13 Guisong WANG Protein markers for estrogen receptor (er)-positive-like and estrogen receptor (er)-negative-like breast cancer
EP4320440A1 (en) 2021-04-06 2024-02-14 BPGbio, Inc. Protein markers for estrogen receptor (er)-positive luminal a(la)-like and luminal b1 (lb1)-like breast cancer
US20240230651A1 (en) 2021-04-06 2024-07-11 Bpgbio, Inc. Protein markers for the prognosis of breast cancer progression
GB202107883D0 (en) 2021-06-02 2021-07-14 Orph Pharma Ip Company Ltd Biomarkers and method for classifying subjects following viral exposure
KR20240148320A (ko) 2021-12-17 2024-10-11 탱고 테라퓨틱스, 인크. N-(6-아미노-5-메틸피리딘-3-일)-2-(벤조[d]티아졸-5-일)-5-메틸피페리딘-1-일)-2-옥소아세트아마이드의결정질 형태, 약제학적 조성물 및 이의 사용 방법
US20250305055A1 (en) 2021-12-22 2025-10-02 Cornell University Prognostic/predictive breast cancer signature
KR20240153335A (ko) 2022-01-26 2024-10-22 탱고 테라퓨틱스, 인크. 화합물 및 사용 방법
JP2025503971A (ja) 2022-01-26 2025-02-06 タンゴ セラピューティクス， インコーポレイテッド 化合物及び使用方法
WO2023146991A1 (en) 2022-01-26 2023-08-03 Tango Therapeutics, Inc. Compounds and methods of use
JP2025504916A (ja) 2022-01-26 2025-02-19 タンゴ セラピューティクス， インコーポレイテッド 化合物及び使用方法
WO2023178295A1 (en) 2022-03-18 2023-09-21 Ludwig Institute For Cancer Research Ltd Methods and systems for analyzing chromatins
KR20240169114A (ko) 2022-04-06 2024-12-02 라리마 테라퓨틱스, 인코포레이티드 프라탁신 대체 요법 모니터링을 위한 프라탁신 민감성 마커
WO2023240201A1 (en) 2022-06-08 2023-12-14 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring progression and treatment of leigh syndrome
WO2024028794A1 (en) 2022-08-02 2024-02-08 Temple Therapeutics BV Methods for treating endometrial and ovarian hyperproliferative disorders
WO2024030659A1 (en) 2022-08-05 2024-02-08 Tango Therapeutics, Inc. An hdac inhibitor for treating cancer with a modified stk11 activity or expression
AU2023366908A1 (en) 2022-10-25 2025-05-08 Tango Therapeutics, Inc. Crystalline forms, pharmaceutical compositions and methods of use thereof
WO2024124044A1 (en) 2022-12-07 2024-06-13 The Brigham And Women’S Hospital, Inc. Compositions and methods targeting sat1 for enhancing anti¬ tumor immunity during tumor progression
WO2024192141A1 (en) 2023-03-13 2024-09-19 Dana-Farber Cancer Institute, Inc. Treatment of cancers having a drug-resistant mesenchymal cell state
WO2024226838A2 (en) 2023-04-25 2024-10-31 The Brigham And Women's Hospital, Inc. Treatment of autoimmune diseases having a pathogenic t cell state
WO2024233665A1 (en) 2023-05-08 2024-11-14 Tango Therapeutics, Inc. Compounds and their use against cancer
WO2024233605A1 (en) 2023-05-08 2024-11-14 Tango Therapeutics, Inc. Compounds and their use against cancer
WO2025155991A2 (en) 2024-01-19 2025-07-24 Bpgbio, Inc. Predictive biomarkers for response to coenzyme q10 treatment in pancreatic cancer
WO2025166308A1 (en) 2024-01-31 2025-08-07 Tango Therapeutics, Inc. Crystalline forms, pharmaceutical compositions and methods of use thereof
WO2025166186A1 (en) 2024-01-31 2025-08-07 Tango Therapeutics, Inc. Crystalline forms, pharmaceutical compositions and methods of use thereof
WO2025202871A1 (en) 2024-03-27 2025-10-02 Pfizer Inc. Methods for identifying biomarkers of treatment response and use thereof with a cdk4 inhibitor
WO2025212475A2 (en) 2024-04-03 2025-10-09 Mars, Incorporated Compositions and methods to detect infectious organisms
WO2025217209A2 (en) 2024-04-08 2025-10-16 Tango Therapeutics, Inc. Crystalline forms of hdac inhibitor and uses thereof
WO2025217297A1 (en) 2024-04-09 2025-10-16 Tango Therapeutics, Inc. Prmt5 inhibitors for use in methods of treating mta-accumulating cancer
WO2025248505A1 (en) 2024-05-31 2025-12-04 Wayne State University Methods for treating endometrial and ovarian hyperproliferative disorders

Family Cites Families (143)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3730844A (en) 1971-08-27 1973-05-01 Purdue Research Foundation Polynucleotide analysis
FR2353856A1 (fr) 1976-06-02 1977-12-30 Chateau Guy Ruban destine a servir de support a une reaction par exemple chimique ou biochimique, et procede d'analyse le mettant en oeuvre
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4500707A (en) 1980-02-29 1985-02-19 University Patents, Inc. Nucleosides useful in the preparation of polynucleotides
US4327073A (en) 1980-04-07 1982-04-27 Huang Henry V Automated method for quantitative analysis of biological fluids
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
EP0063810B1 (en) 1981-04-29 1986-03-05 Ciba-Geigy Ag New devices and kits for immunological analysis
US4373071A (en) 1981-04-30 1983-02-08 City Of Hope Research Institute Solid-phase synthesis of polynucleotides
FI63596C (fi) 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
US4483920A (en) 1982-05-17 1984-11-20 Hahnemann University Immobilization of message RNA directly from cells onto filter material
US4556643A (en) 1982-07-26 1985-12-03 Agracetus Assay method and probe for polynucleotide sequences
DE3301833A1 (de) 1983-01-20 1984-07-26 Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig Verfahren zur simultanen synthese mehrerer oligonocleotide an fester phase
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
US4591570A (en) 1983-02-02 1986-05-27 Centocor, Inc. Matrix of antibody-coated spots for determination of antigens
US4584277A (en) 1983-04-05 1986-04-22 Syntex (U.S.A.) Inc. Fluorescent multiparameter particle analysis
GB8314523D0 (en) 1983-05-25 1983-06-29 Lowe C R Diagnostic device
US4987065A (en) 1983-07-05 1991-01-22 Enzo Biochem, Inc. In vivo labelling of polynucleotide sequences
US4542102A (en) 1983-07-05 1985-09-17 Molecular Diagnostics, Inc. Coupling of nucleic acids to solid support by photochemical methods
US4677054A (en) 1983-08-08 1987-06-30 Sloan-Kettering Institute For Cancer Research Method for simple analysis of relative nucleic acid levels in multiple small samples by cytoplasmic dot hybridization
AU575586B2 (en) 1983-09-02 1988-08-04 Syngene, Inc. Oligonucleotide synthesis employing primer with oxidzable substituents in system
US4849513A (en) 1983-12-20 1989-07-18 California Institute Of Technology Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
US4613566A (en) 1984-01-23 1986-09-23 President And Fellows Of Harvard College Hybridization assay and kit therefor
FI71768C (fi) 1984-02-17 1987-02-09 Orion Yhtymae Oy Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.
GB8405437D0 (en) 1984-03-01 1984-04-04 Amersham Int Plc Detecting polynucleotide sequences
US4704353A (en) 1984-04-27 1987-11-03 Molecular Devices Corporation Photoresponsive redox detection and discrimination
US4670380A (en) 1984-05-23 1987-06-02 Molecular Diagnostics, Inc. Assays utilizing labeled nucleic acid probes
IL75464A (en) 1984-06-12 1990-08-31 Orgenics Ltd Method and apparatus for multi-analyte assay
US4755458A (en) 1984-08-30 1988-07-05 Enzo Biochem, Inc. Composition and method for the detection of the presence of a polynucleotide sequence of interest
US4820630A (en) 1984-11-23 1989-04-11 Digene Diagnostics, Incorporated Assay for nucleic acid sequences, particularly genetic lesions, using interactive labels
US5064754A (en) 1984-12-14 1991-11-12 Mills Randell L Genomic sequencing method
US4670379A (en) 1984-12-19 1987-06-02 E. I. Du Pont De Nemours And Company Polynucleotide hydridization assays employing catalyzed luminescence
US5026840A (en) 1985-01-10 1991-06-25 Molecular Diagnostics, Inc. Photochemical nucleic acid-labeling reagent having a polyalklamine spacer
US4767700A (en) 1985-02-15 1988-08-30 Beckman Research Institute Of The City Of Hope Detection of particular nucleotide sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
NZ215865A (en) 1985-04-22 1988-10-28 Commw Serum Lab Commission Method of determining the active site of a receptor-binding analogue
FR2583772B1 (fr) 1985-06-20 1987-08-28 Roussel Uclaf Nouveaux supports, la preparation de ces supports, les intermediaires nouveaux obtenus, leur application a la synthese d'oligonucleotides et les nouveaux nucleosides et oligonucleotides relies aux supports ainsi obtenus
FR2584090B1 (fr) 1985-06-27 1987-08-28 Roussel Uclaf Nouveaux supports, leur preparation et les intermediaires obtenus, leur application a la synthese d'oligonucleotides et les nouveaux nucleosides et oligonucleotides relies aux supports ainsi obtenus
WO1987000926A1 (en) 1985-08-05 1987-02-12 Rijksuniversiteit Leiden Labelled macromolecules; a process for their preparation and their use for immunological or immunocytochemical assays
US4868104A (en) 1985-09-06 1989-09-19 Syntex (U.S.A.) Inc. Homogeneous assay for specific polynucleotides
US4868105A (en) 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
ATE88761T1 (de) 1986-01-10 1993-05-15 Amoco Corp Kompetitiver homogener test.
US5447841A (en) 1986-01-16 1995-09-05 The Regents Of The Univ. Of California Methods for chromosome-specific staining
US4855225A (en) 1986-02-07 1989-08-08 Applied Biosystems, Inc. Method of detecting electrophoretically separated oligonucleotides
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
US5348855A (en) 1986-03-05 1994-09-20 Miles Inc. Assay for nucleic acid sequences in an unpurified sample
NO870613L (no) 1986-03-05 1987-09-07 Molecular Diagnostics Inc Deteksjon av mikroorganismer i en prŸve inneholdende nukleinsyre.
US4728591A (en) 1986-03-07 1988-03-01 Trustees Of Boston University Self-assembled nanometer lithographic masks and templates and method for parallel fabrication of nanometer scale multi-device structures
US4925785A (en) 1986-03-07 1990-05-15 Biotechnica Diagnostics, Inc. Nucleic acid hybridization assays
CA1284931C (en) 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US5310893A (en) 1986-03-31 1994-05-10 Hoffmann-La Roche Inc. Method for HLA DP typing
US5256549A (en) 1986-03-28 1993-10-26 Chiron Corporation Purification of synthetic oligomers
US5153319A (en) 1986-03-31 1992-10-06 University Patents, Inc. Process for preparing polynucleotides
US4981783A (en) * 1986-04-16 1991-01-01 Montefiore Medical Center Method for detecting pathological conditions
US5021550A (en) 1986-10-07 1991-06-04 Thomas Jefferson University Method for preventing deletion sequences in solid phase synthesis
US5028525A (en) 1986-11-24 1991-07-02 Regents Of The University Of California Method of preparing and applying single stranded DNA probes to double stranded target DNAs in situ
US5252974A (en) * 1986-12-24 1993-10-12 Zdzislaw Gulczynski Encoder with error correction particularly for flash analog-to-digital converters
AU601021B2 (en) 1987-03-11 1990-08-30 Molecular Diagnostics, Inc. Assay for necleic acid sequences in a sample
JPS63223557A (ja) 1987-03-13 1988-09-19 Nec Corp 半導体バイオセンサの製造方法
US6270961B1 (en) 1987-04-01 2001-08-07 Hyseq, Inc. Methods and apparatus for DNA sequencing and DNA identification
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5525464A (en) 1987-04-01 1996-06-11 Hyseq, Inc. Method of sequencing by hybridization of oligonucleotide probes
US5100777A (en) 1987-04-27 1992-03-31 Tanox Biosystems, Inc. Antibody matrix device and method for evaluating immune status
SE458968B (sv) 1987-06-16 1989-05-22 Wallac Oy Biospecifikt analysfoerfarande foer flera analyter i vilket ingaar partikelraekning och maerkning med fluorescerande maerksubstanser
US4874500A (en) 1987-07-15 1989-10-17 Sri International Microelectrochemical sensor and sensor array
US4921805A (en) 1987-07-29 1990-05-01 Life Technologies, Inc. Nucleic acid capture method
US4923901A (en) 1987-09-04 1990-05-08 Millipore Corporation Membranes with bound oligonucleotides and peptides
US5082830A (en) 1988-02-26 1992-01-21 Enzo Biochem, Inc. End labeled nucleotide probe
GB8810400D0 (en) * 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US4988617A (en) 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
IL89964A0 (en) 1988-04-15 1989-12-15 Montefiore Med Center Method for determining malignant progression,cdna,polypeptides encoded thereby and pharmaceutical compositions containing the same
US5002867A (en) * 1988-04-25 1991-03-26 Macevicz Stephen C Nucleic acid sequence determination by multiple mixed oligonucleotide probes
US5700637A (en) * 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
EP0451141B1 (en) * 1988-05-20 1998-11-18 F. Hoffmann-La Roche Ag Immobilized sequence-specific probes
US5013669A (en) 1988-06-01 1991-05-07 Smithkline Diagnostics, Inc. Mass producible biologically active solid phase devices
US5204268A (en) 1988-06-02 1993-04-20 Fuji Photo Film Co., Ltd. Method and apparatus for applying liquid samples
EP0427745A4 (en) * 1988-07-14 1992-11-25 Baylor College Of Medicine Solid phase assembly and reconstruction of biopolymers
US5188963A (en) 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
US4992383A (en) 1988-08-05 1991-02-12 Porton Instruments, Inc. Method for protein and peptide sequencing using derivatized glass supports
US5185243A (en) 1988-08-25 1993-02-09 Syntex (U.S.A.) Inc. Method for detection of specific nucleic acid sequences
GB8822228D0 (en) 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
US5389512A (en) 1988-10-07 1995-02-14 Hoffman-La Roche Inc. Method for determining the relative amount of a viral nucleic acid segment in a sample by the polymerase chain reaction
US5200051A (en) 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5489507A (en) 1988-11-30 1996-02-06 Perkin-Elmer Corporation DNA detection by color complementation
US5047524A (en) 1988-12-21 1991-09-10 Applied Biosystems, Inc. Automated system for polynucleotide synthesis and purification
US5200312A (en) 1989-01-30 1993-04-06 The United States Of America As Represented By The Secretary Of The Navy Membrane based dot immunoassay and method of use
JPH02299598A (ja) 1989-04-14 1990-12-11 Ro Inst For Molecular Genetics & Geneteic Res 微視的サイズの別個の粒子と結合している核酸試料中のごく短い配列の全部または一部のオリゴヌクレチドプローブとのハイブリダイゼーションによる決定法
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5242974A (en) 1991-11-22 1993-09-07 Affymax Technologies N.V. Polymer reversal on solid surfaces
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6309822B1 (en) * 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5141813A (en) 1989-08-28 1992-08-25 Clontech Laboratories, Inc. Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis
US5232829A (en) 1989-09-29 1993-08-03 Hoffmann-La Roche Inc. Detection of chlamydia trachomatis by polymerase chain reaction using biotin labelled lina primers and capture probes
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5215882A (en) 1989-11-30 1993-06-01 Ortho Diagnostic Systems, Inc. Method of immobilizing nucleic acid on a solid surface for use in nucleic acid hybridization assays
US5091652A (en) 1990-01-12 1992-02-25 The Regents Of The University Of California Laser excited confocal microscope fluorescence scanner and method
DK43590A (da) * 1990-02-19 1991-08-20 Ole Schou Nielsen Anordning ved paa stolper anbragte skilte
DK0455905T3 (da) 1990-05-11 1998-12-07 Microprobe Corp Dipsticks til nukleinsyrehybridiseringsassays og fremgangsmåde til kovalent immobilisering af oligonukleotider
US5252296A (en) 1990-05-15 1993-10-12 Chiron Corporation Method and apparatus for biopolymer synthesis
DE4024545A1 (de) 1990-08-02 1992-02-06 Boehringer Mannheim Gmbh Verfahren und vorrichtung zum dosierten zufuehren einer biochemischen analysefluessigkeit auf ein target
US5173260A (en) * 1990-09-17 1992-12-22 Eastman Kodak Company Beads fused to a test device support
EP0557456A4 (en) 1990-11-14 1995-11-15 Siska Diagnostics Inc Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor
WO1992010092A1 (en) * 1990-12-06 1992-06-25 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
DE69132905T2 (de) * 1990-12-06 2002-08-01 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Detektion von Nukleinsäuresequenzen
RU1794088C (ru) * 1991-03-18 1993-02-07 Институт Молекулярной Биологии Ан@ Ссср Способ определени нуклеотидной последовательности ДНК и устройство дл его осуществлени
US5422241A (en) * 1991-07-03 1995-06-06 Ambion, Inc. Methods for the recovery of nucleic acids from reaction mixtures
US5556748A (en) 1991-07-30 1996-09-17 Xenopore Corporation Methods of sandwich hybridization for the quantitative analysis of oligonucleotides
WO1993004199A2 (en) 1991-08-20 1993-03-04 Scientific Generics Limited Methods of detecting or quantitating nucleic acids and of producing labelled immobilised nucleic acids
US5474796A (en) 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5605662A (en) 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5326691A (en) 1991-11-21 1994-07-05 John Hozier Micro-libraries and methods of making and manipulating them methods for generating and analyzing micro-libraries
US5412087A (en) 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
FR2684688B1 (fr) 1991-12-04 1994-03-18 Bertin Et Cie Procede de selection d'au moins un crible de mutations, son application a un procede d'identification rapide d'alleles de systemes polymorphes et dispositif pour sa mise en óoeuvre.
WO1993017126A1 (en) * 1992-02-19 1993-09-02 The Public Health Research Institute Of The City Of New York, Inc. Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids
JPH05236997A (ja) 1992-02-28 1993-09-17 Hitachi Ltd ポリヌクレオチド捕捉用チップ
EP0636186B1 (en) 1992-04-03 1998-11-25 The Perkin-Elmer Corporation Probe composition and method
US5518883A (en) 1992-07-02 1996-05-21 Soini; Erkki J. Biospecific multiparameter assay method
US6114114A (en) * 1992-07-17 2000-09-05 Incyte Pharmaceuticals, Inc. Comparative gene transcript analysis
US5795714A (en) 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
DE69431719T2 (de) * 1993-06-25 2003-09-18 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Hybridisierung und sequenzierung von nukleinsäuren
US5837832A (en) * 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5512430A (en) 1993-07-13 1996-04-30 Hri Research, Inc. Diagnostic array for virus infection
RU2041263C1 (ru) * 1993-08-11 1995-08-09 Геннадий Моисеевич Ершов Способ микродозирования водных растворов веществ на носитель и устройство для его осуществления
RU2041262C1 (ru) * 1993-08-11 1995-08-09 Институт молекулярной биологии им.В.А.Энгельгардта РАН Способ иммобилизации водорастворимых биоорганических соединений на капиллярно-пористый носитель
RU2041261C1 (ru) * 1993-08-11 1995-08-09 Институт молекулярной биологии им.В.А.Энгельгардта РАН Способ изготовления матрицы для детектирования мисматчей
US5472842A (en) 1993-10-06 1995-12-05 The Regents Of The University Of California Detection of amplified or deleted chromosomal regions
EP0730663B1 (en) * 1993-10-26 2003-09-24 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5610287A (en) 1993-12-06 1997-03-11 Molecular Tool, Inc. Method for immobilizing nucleic acid molecules
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
EP0743989B1 (en) 1994-02-14 2007-03-21 Smithkline Beecham Corporation Methed of identifying differentially expressed genes
US6015880A (en) 1994-03-16 2000-01-18 California Institute Of Technology Method and substrate for performing multiple sequential reactions on a matrix
DE69503126T2 (de) * 1994-05-05 1998-11-12 Beckman Instruments Inc Repetitive oligonukleotide matrix
US5571639A (en) * 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5501954A (en) * 1994-06-13 1996-03-26 Genzyme Corporation Method of detecting cellular material
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5795716A (en) * 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US6974666B1 (en) * 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US5830645A (en) 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5690894A (en) * 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US20020042048A1 (en) 1997-01-16 2002-04-11 Radoje Drmanac Methods and compositions for detection or quantification of nucleic acid species

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US6548257B2 (en) 2003-04-15
JPH11512293A (ja) 1999-10-26
US20050158746A1 (en) 2005-07-21
US20050202500A1 (en) 2005-09-15
WO1997010365A1 (en) 1997-03-20
DE69625920T2 (de) 2003-10-30
US20030215841A1 (en) 2003-11-20
EP0853679B1 (en) 2003-01-22
US20020012940A1 (en) 2002-01-31
US6927032B2 (en) 2005-08-09
US6040138A (en) 2000-03-21

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