PL2893040T3 - Sposoby wykrywania rzadkich mutacji i wariantu liczby kopii - Google Patents

Sposoby wykrywania rzadkich mutacji i wariantu liczby kopii

Info

Publication number
PL2893040T3
PL2893040T3 PL13834427T PL13834427T PL2893040T3 PL 2893040 T3 PL2893040 T3 PL 2893040T3 PL 13834427 T PL13834427 T PL 13834427T PL 13834427 T PL13834427 T PL 13834427T PL 2893040 T3 PL2893040 T3 PL 2893040T3
Authority
PL
Poland
Prior art keywords
methods
copy number
number variation
rare mutations
detect rare
Prior art date
Application number
PL13834427T
Other languages
English (en)
Inventor
AmirAli TALASAZ
Helmy Eltoukhy
Original Assignee
Guardant Health Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50237580&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2893040(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Guardant Health Inc filed Critical Guardant Health Inc
Publication of PL2893040T3 publication Critical patent/PL2893040T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/165—Mathematical modelling, e.g. logarithm, ratio
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2545/00—Reactions characterised by their quantitative nature
    • C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
    • C12Q2545/114—Reactions characterised by their quantitative nature the purpose being quantitative analysis involving a quantitation step
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indexing, Searching, Synchronizing, And The Amount Of Synchronization Travel Of Record Carriers (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
PL13834427T 2012-09-04 2013-09-04 Sposoby wykrywania rzadkich mutacji i wariantu liczby kopii PL2893040T3 (pl)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201261696734P 2012-09-04 2012-09-04
US201261704400P 2012-09-21 2012-09-21
US201361793997P 2013-03-15 2013-03-15
US201361845987P 2013-07-13 2013-07-13
PCT/US2013/058061 WO2014039556A1 (en) 2012-09-04 2013-09-04 Systems and methods to detect rare mutations and copy number variation
EP13834427.0A EP2893040B1 (en) 2012-09-04 2013-09-04 Methods to detect rare mutations and copy number variation

Publications (1)

Publication Number Publication Date
PL2893040T3 true PL2893040T3 (pl) 2019-05-31

Family

ID=50237580

Family Applications (2)

Application Number Title Priority Date Filing Date
PL13834427T PL2893040T3 (pl) 2012-09-04 2013-09-04 Sposoby wykrywania rzadkich mutacji i wariantu liczby kopii
PL19192885T PL3591073T3 (pl) 2012-09-04 2013-09-04 Sposoby wykrywania rzadkich mutacji i zmienności liczby kopii

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL19192885T PL3591073T3 (pl) 2012-09-04 2013-09-04 Sposoby wykrywania rzadkich mutacji i zmienności liczby kopii

Country Status (16)

Country Link
US (31) US10041127B2 (pl)
EP (6) EP3591073B1 (pl)
JP (6) JP6275145B2 (pl)
KR (6) KR102028375B1 (pl)
CN (2) CN104781421B (pl)
CA (2) CA3190199A1 (pl)
DE (1) DE202013012824U1 (pl)
DK (1) DK2893040T5 (pl)
ES (5) ES2968333T3 (pl)
GB (1) GB2533006B (pl)
IL (3) IL305303A (pl)
MX (1) MX367963B (pl)
PL (2) PL2893040T3 (pl)
PT (1) PT2893040T (pl)
SG (2) SG10202000486VA (pl)
WO (1) WO2014039556A1 (pl)

Families Citing this family (382)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11111544B2 (en) * 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US10083273B2 (en) 2005-07-29 2018-09-25 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
EP2473638B1 (en) 2009-09-30 2017-08-09 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US8825412B2 (en) 2010-05-18 2014-09-02 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US8916344B2 (en) 2010-11-15 2014-12-23 Exact Sciences Corporation Methylation assay
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
EP2656263B1 (en) 2010-12-22 2019-11-06 Natera, Inc. Methods for non-invasive prenatal paternity testing
KR20140024270A (ko) 2010-12-30 2014-02-28 파운데이션 메디신 인코포레이티드 종양 샘플의 다유전자 분석의 최적화
JP6153874B2 (ja) 2011-02-09 2017-06-28 ナテラ， インコーポレイテッド 非侵襲的出生前倍数性呼び出しのための方法
WO2012129363A2 (en) 2011-03-24 2012-09-27 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
AU2012242847B2 (en) 2011-04-15 2017-01-19 The Johns Hopkins University Safe sequencing system
US20140235474A1 (en) 2011-06-24 2014-08-21 Sequenom, Inc. Methods and processes for non invasive assessment of a genetic variation
US20130079241A1 (en) 2011-09-15 2013-03-28 Jianhua Luo Methods for Diagnosing Prostate Cancer and Predicting Prostate Cancer Relapse
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140242588A1 (en) 2011-10-06 2014-08-28 Sequenom, Inc Methods and processes for non-invasive assessment of genetic variations
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
EP2805280B1 (en) 2012-01-20 2022-10-05 Sequenom, Inc. Diagnostic processes that factor experimental conditions
HUE053360T2 (hu) 2012-02-17 2021-06-28 Hutchinson Fred Cancer Res Kompozíciók és eljárások mutációk pontos azonosítására
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
ES2828661T3 (es) 2012-03-20 2021-05-27 Univ Washington Through Its Center For Commercialization Métodos para reducir la tasa de error de la secuenciación de ADN masiva en paralelo mediante el uso de la secuenciación de secuencia consenso bicatenaria
HK1203220A1 (en) * 2012-05-04 2015-10-23 考利达基因组股份有限公司 Methods for determining absolute genome-wide copy number variations of complex tumors
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US11261494B2 (en) 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
DE202013012824U1 (de) 2012-09-04 2020-03-10 Guardant Health, Inc. Systeme zum Erfassen von seltenen Mutationen und einer Kopienzahlvariation
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
ES2701742T3 (es) 2012-10-29 2019-02-25 Univ Johns Hopkins Prueba de Papanicolaou para cánceres de ovario y de endometrio
US9218450B2 (en) * 2012-11-29 2015-12-22 Roche Molecular Systems, Inc. Accurate and fast mapping of reads to genome
EP3561072A1 (en) 2012-12-10 2019-10-30 Resolution Bioscience, Inc. Methods for targeted genomic analysis
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
ES2859645T3 (es) 2013-03-14 2021-10-04 Mayo Found Medical Education & Res Detección de neoplasia
CN114574581A (zh) 2013-03-15 2022-06-03 夸登特健康公司 检测稀有突变和拷贝数变异的系统和方法
WO2014144092A1 (en) 2013-03-15 2014-09-18 Nugen Technologies, Inc. Sequential sequencing
EP4187543A1 (en) 2013-04-03 2023-05-31 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10699800B2 (en) 2013-05-24 2020-06-30 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
KR102299305B1 (ko) 2013-06-21 2021-09-06 시쿼넘, 인코포레이티드 유전적 변이의 비침습 평가를 위한 방법 및 프로세스
US10577655B2 (en) 2013-09-27 2020-03-03 Natera, Inc. Cell free DNA diagnostic testing standards
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
DK3053071T3 (da) 2013-10-04 2024-01-22 Sequenom Inc Fremgangsmåder og processer til ikke-invasiv bedømmelse af genetiske variationer
EP3495496B1 (en) 2013-10-07 2020-11-25 Sequenom, Inc. Methods and processes for non-invasive assessment of chromosome alterations
JP6534191B2 (ja) 2013-10-21 2019-06-26 ベリナタ ヘルス インコーポレイテッド コピー数変動を決定することにおける検出の感度を向上させるための方法
CA2929557C (en) 2013-11-07 2023-09-26 The Board Of Trustees Of The Leland Stanford Junior University Cell-free nucleic acids for the analysis of the human microbiome and components thereof
CA2929596C (en) 2013-11-13 2022-07-05 Nugen Technologies, Inc. Compositions and methods for identification of a duplicate sequencing read
ES2660989T3 (es) 2013-12-28 2018-03-27 Guardant Health, Inc. Métodos y sistemas para detectar variantes genéticas
EP3090062B1 (en) 2013-12-30 2020-08-26 University of Pittsburgh - of the Commonwealth System of Higher Education Fusion genes associated with progressive prostate cancer
US12492429B2 (en) 2014-04-21 2025-12-09 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
CN113774132A (zh) * 2014-04-21 2021-12-10 纳特拉公司 检测染色体片段中的突变和倍性
ES2844229T3 (es) 2014-05-13 2021-07-21 Univ Texas Mutaciones génicas y alteraciones en el número de copias de EGFR, KRAS y MET
EP3149202A1 (en) * 2014-05-26 2017-04-05 Ebios Futura S.r.l. Method of prenatal diagnosis
AU2015267190B2 (en) * 2014-05-30 2020-10-01 Sequenom, Inc. Chromosome representation determinations
JP6659672B2 (ja) * 2014-05-30 2020-03-04 ベリナタ ヘルス インコーポレイテッド 胎児染色体部分異数性およびコピー数変動の検出
US20180173846A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
EP3193944B1 (en) 2014-07-17 2021-04-07 University of Pittsburgh - Of the Commonwealth System of Higher Education Methods of treating cells containing fusion genes
TWI895765B (zh) 2014-07-18 2025-09-01 香港中文大學 Dna混合物中之組織甲基化模式分析
GB201412834D0 (en) * 2014-07-18 2014-09-03 Cancer Rec Tech Ltd A method for detecting a genetic variant
CA2956208C (en) 2014-07-25 2025-07-08 University Of Washington METHODS FOR DETERMINING TISSUES AND/OR CELL TYPES RENDERING CELL-FREE DNA AND RELATED METHODS FOR DETERMINING A DISEASE OR DISORDER
EP3175000B1 (en) 2014-07-30 2020-07-29 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CN107075581B (zh) * 2014-08-06 2022-03-18 纽亘技术公司 由靶向测序进行数字测量
US20160053301A1 (en) 2014-08-22 2016-02-25 Clearfork Bioscience, Inc. Methods for quantitative genetic analysis of cell free dna
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
CA2967447C (en) 2014-12-05 2025-07-08 Foundation Medicine, Inc. MULTIGEN ANALYSIS OF TUMOR SAMPLES
WO2016090584A1 (zh) * 2014-12-10 2016-06-16 深圳华大基因研究院 确定肿瘤核酸浓度的方法和装置
AU2015360298B2 (en) 2014-12-12 2018-06-07 Verinata Health, Inc. Using cell-free DNA fragment size to determine copy number variations
WO2016095093A1 (zh) * 2014-12-15 2016-06-23 天津华大基因科技有限公司 肿瘤筛查方法、目标区域变异检测方法和装置
US10020300B2 (en) 2014-12-18 2018-07-10 Agilome, Inc. Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids
US10429342B2 (en) 2014-12-18 2019-10-01 Edico Genome Corporation Chemically-sensitive field effect transistor
US9859394B2 (en) 2014-12-18 2018-01-02 Agilome, Inc. Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids
US10006910B2 (en) 2014-12-18 2018-06-26 Agilome, Inc. Chemically-sensitive field effect transistors, systems, and methods for manufacturing and using the same
US9618474B2 (en) 2014-12-18 2017-04-11 Edico Genome, Inc. Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids
US9857328B2 (en) 2014-12-18 2018-01-02 Agilome, Inc. Chemically-sensitive field effect transistors, systems and methods for manufacturing and using the same
CN107111693A (zh) * 2014-12-29 2017-08-29 考希尔股份有限公司 用于确定高同源性区域中的基因型的方法
PL4574996T3 (pl) * 2014-12-31 2026-03-02 Guardant Health, Inc. Wykrywanie i leczenie chorób wykazujących heterogeniczność komórek chorobowych oraz systemy i sposoby przekazywania wyników testów
US10364467B2 (en) * 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
SG11201706529TA (en) * 2015-02-10 2017-09-28 Univ Hong Kong Chinese Detecting mutations for cancer screening and fetal analysis
WO2016160454A1 (en) 2015-03-27 2016-10-06 Exact Sciences Corporation Detecting esophageal disorders
CN107708556B (zh) 2015-05-01 2022-01-04 夸登特健康公司 诊断方法
DK3294906T3 (en) 2015-05-11 2024-08-05 Natera Inc Methods for determining ploidy
CA2986036C (en) 2015-05-18 2022-07-26 Karius, Inc. Compositions and methods for enriching populations of nucleic acids
US10395759B2 (en) * 2015-05-18 2019-08-27 Regeneron Pharmaceuticals, Inc. Methods and systems for copy number variant detection
JP6698708B2 (ja) * 2015-06-09 2020-05-27 ライフ テクノロジーズ コーポレーション 分子タグ付けのための方法、システム、組成物、キット、装置、及びコンピュータ可読媒体
CN107408163B (zh) * 2015-06-24 2021-03-05 吉尼努斯公司 用于分析基因的方法及装置
GB201819855D0 (en) * 2015-07-07 2019-01-23 Farsight Genome Systems Inc Methods and systems for sequencing-based variant detection
AU2016293025A1 (en) * 2015-07-13 2017-11-02 Agilent Technologies Belgium Nv System and methodology for the analysis of genomic data obtained from a subject
CN108138230B (zh) * 2015-07-21 2023-03-10 夸登特健康公司 用于捕获融合基因的锁核酸
US10453556B2 (en) * 2015-07-23 2019-10-22 The Chinese University Of Hong Kong Analysis of fragmentation patterns of cell-free DNA
CN108138220A (zh) * 2015-07-29 2018-06-08 普罗格尼迪公司 遗传分析的系统和方法
ES2745556T3 (es) 2015-07-29 2020-03-02 Progenity Inc Acidos nucleicos y métodos para detectar anomalías cromosómicas
WO2017027473A1 (en) * 2015-08-07 2017-02-16 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Methods for predicting prostate cancer relapse
WO2017027653A1 (en) 2015-08-11 2017-02-16 The Johns Hopkins University Assaying ovarian cyst fluid
KR20250172724A (ko) 2015-08-31 2025-12-09 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 위 신생물 검출 방법
US11302416B2 (en) * 2015-09-02 2022-04-12 Guardant Health Machine learning for somatic single nucleotide variant detection in cell-free tumor nucleic acid sequencing applications
EP3347466B9 (en) * 2015-09-08 2024-06-26 Cold Spring Harbor Laboratory Genetic copy number determination using high throughput multiplex sequencing of smashed nucleotides
CN108474040B (zh) 2015-10-09 2023-05-16 夸登特健康公司 使用无细胞dna的基于群体的治疗推荐
KR101848438B1 (ko) 2015-10-29 2018-04-13 바이오코아 주식회사 디지털 pcr을 이용한 산전진단 방법
KR20250073555A (ko) 2015-10-30 2025-05-27 이그잭트 사이언시즈 코포레이션 복합 증폭 검출 분석 및 혈장으로부터 dna의 분리 및 검출 방법
CA3004435A1 (en) 2015-11-11 2017-05-18 Resolution Bioscience, Inc. High efficiency construction of dna libraries
US20180330050A1 (en) * 2015-11-16 2018-11-15 Mayo Foundation For Medical Education And Research Detecting copy number variations
PL3387152T3 (pl) 2015-12-08 2022-05-09 Twinstrand Biosciences, Inc. Ulepszone adaptory, sposoby i kompozycje do sekwencjonowania dupleksowego
CN117174167A (zh) * 2015-12-17 2023-12-05 夸登特健康公司 通过分析无细胞dna确定肿瘤基因拷贝数的方法
CN108603229A (zh) * 2016-01-22 2018-09-28 格瑞尔公司 用于高保真测序的方法和系统
WO2017136603A1 (en) 2016-02-02 2017-08-10 Guardant Health, Inc. Cancer evolution detection and diagnostic
US10095831B2 (en) 2016-02-03 2018-10-09 Verinata Health, Inc. Using cell-free DNA fragment size to determine copy number variations
US11479878B2 (en) 2016-03-16 2022-10-25 Dana-Farber Cancer Institute, Inc. Methods for genome characterization
EP3433382B1 (en) 2016-03-25 2021-09-01 Karius, Inc. Synthetic nucleic acid spike-ins
WO2017181146A1 (en) 2016-04-14 2017-10-19 Guardant Health, Inc. Methods for early detection of cancer
US11384382B2 (en) 2016-04-14 2022-07-12 Guardant Health, Inc. Methods of attaching adapters to sample nucleic acids
ITUA20162640A1 (it) * 2016-04-15 2017-10-15 Menarini Silicon Biosystems Spa Metodo e kit per la generazione di librerie di dna per sequenziamento massivo parallelo
DK3443119T3 (da) 2016-04-15 2022-05-23 Natera Inc Fremgangsmåde til bestemmelse af lunge cancer
US20170298422A1 (en) 2016-04-18 2017-10-19 The Board Of Trustees Of The Leland Stanford Junior University Simultaneous single-molecule epigenetic imaging of dna methylation and hydroxymethylation
CN116064796A (zh) 2016-05-05 2023-05-05 精密科学公司 通过分析甲基化dna来检测肺肿瘤
CN109511265B (zh) 2016-05-16 2023-07-14 安可济控股有限公司 通过链鉴定改进测序的方法
EP3459115A4 (en) 2016-05-16 2020-04-08 Agilome, Inc. GRAPHENE FETING DEVICES, SYSTEMS, AND METHODS OF USE THEREOF FOR NUCLEIC ACID SEQUENCING
CN110168099B (zh) * 2016-06-07 2024-06-07 加利福尼亚大学董事会 用于疾病和病症分析的无细胞dna甲基化模式
EP4257701A3 (en) 2016-06-30 2023-12-20 Grail, LLC Differential tagging of rna for preparation of a cell-free dna/rna sequencing library
CN107577917A (zh) * 2016-07-05 2018-01-12 魏霖静 一种生物信息学高性能信息化管理系统及数据处理方法
CA3030038A1 (en) 2016-07-06 2018-01-11 Guardant Health, Inc. Methods for fragmentome profiling of cell-free nucleic acids
CA3030430A1 (en) 2016-07-15 2018-01-18 The Regents Of The University Of California Methods of producing nucleic acid libraries
US11200963B2 (en) 2016-07-27 2021-12-14 Sequenom, Inc. Genetic copy number alteration classifications
JP7217224B2 (ja) 2016-08-25 2023-02-02 レゾリューション バイオサイエンス， インコーポレイテッド Ｄｎａ試料中のゲノムコピー変化の検出方法
KR102711907B1 (ko) * 2016-09-22 2024-09-27 일루미나, 인코포레이티드 체세포 복제수 변이 검출
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
KR20240155386A (ko) 2016-09-30 2024-10-28 가던트 헬쓰, 인크. 무세포 핵산의 다중-해상도 분석 방법
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
EP4656736A3 (en) 2016-10-12 2026-02-18 Bellwether Bio, Inc. Determining cell type origin of circulating cell-free dna with molecular counting
CA3041647A1 (en) 2016-10-24 2018-05-03 The Chinese University Of Hong Kong Methods and systems for tumor detection
WO2018081465A1 (en) * 2016-10-26 2018-05-03 Pathway Genomics Corporation Systems and methods for characterizing nucleic acid in a biological sample
CN106566877A (zh) * 2016-10-31 2017-04-19 天津诺禾致源生物信息科技有限公司 检测基因突变的方法和装置
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
JP2019534051A (ja) 2016-11-15 2019-11-28 パーソナル ゲノム ダイアグノスティクス インコーポレイテッド 遺伝子型決定アッセイにおける一意でないバーコード
CA3039685A1 (en) 2016-11-30 2018-06-07 The Chinese University Of Hong Kong Analysis of cell-free dna in urine and other samples
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
EP3552128B1 (en) * 2016-12-08 2025-07-23 Life Technologies Corporation Methods for detecting mutation load from a tumor sample
US20180166170A1 (en) * 2016-12-12 2018-06-14 Konstantinos Theofilatos Generalized computational framework and system for integrative prediction of biomarkers
WO2018119452A2 (en) 2016-12-22 2018-06-28 Guardant Health, Inc. Methods and systems for analyzing nucleic acid molecules
CN106701956A (zh) * 2017-01-11 2017-05-24 上海思路迪生物医学科技有限公司 ctDNA的数字化深度测序技术
US11929145B2 (en) 2017-01-20 2024-03-12 Sequenom, Inc Methods for non-invasive assessment of genetic alterations
WO2018140521A1 (en) 2017-01-24 2018-08-02 Sequenom, Inc. Methods and processes for assessment of genetic variations
ES2990117T3 (es) * 2017-01-25 2024-11-28 Univ Hong Kong Chinese Aplicaciones de diagnóstico que utilizan fragmentos de ácido nucleico
JP7289264B2 (ja) 2017-01-27 2023-06-09 エグザクト サイエンシーズ コーポレーション メチル化ｄｎａの分析による結腸腫瘍の検出
WO2018156418A1 (en) 2017-02-21 2018-08-30 Natera, Inc. Compositions, methods, and kits for isolating nucleic acids
CN106755547A (zh) * 2017-03-15 2017-05-31 上海亿康医学检验所有限公司 一种膀胱癌的无创检测及其复发监测方法
PT3596233T (pt) 2017-03-17 2022-08-22 Sequenom Inc Métodos e processos para avaliação de mosaicismo genético
US11584958B2 (en) 2017-03-31 2023-02-21 Grail, Llc Library preparation and use thereof for sequencing based error correction and/or variant identification
US12492430B2 (en) 2017-04-11 2025-12-09 Tecan Genomics, Inc. Library quantitation and qualification
CA3059370C (en) 2017-04-12 2022-05-10 Karius, Inc. Methods for concurrent analysis of dna and rna in mixed samples
US11342047B2 (en) 2017-04-21 2022-05-24 Illumina, Inc. Using cell-free DNA fragment size to detect tumor-associated variant
EP3635138B1 (en) * 2017-05-15 2024-07-03 Katholieke Universiteit Leuven Method for analysing cell-free nucleic acids
WO2018213235A1 (en) 2017-05-16 2018-11-22 Life Technologies Corporation Methods for compression of molecular tagged nucleic acid sequence data
EP3625341B1 (en) * 2017-05-16 2024-09-25 Guardant Health, Inc. Identification of somatic or germline origin for cell-free dna
KR102145417B1 (ko) * 2017-05-24 2020-08-19 지니너스 주식회사 무세포 핵산으로부터 수득된 서열 분석 데이터에 대한 배경 대립인자의 빈도 분포를 생성하는 방법 및 이를 이용하여 무세포 핵산으로부터 변이를 검출하는 방법
WO2018227202A1 (en) * 2017-06-09 2018-12-13 Bellwether Bio, Inc. Determination of cancer type in a subject by probabilistic modeling of circulating nucleic acid fragment endpoints
SG11201911538YA (en) * 2017-06-20 2020-01-30 Illumina Inc Methods and systems for decomposition and quantification of dna mixtures from multiple contributors of known or unknown genotypes
US12054711B2 (en) 2017-07-14 2024-08-06 City Of Hope Meta-stable oligonucleotides junctions for delivery of therapeutics
EP3431611A1 (en) * 2017-07-21 2019-01-23 Menarini Silicon Biosystems S.p.A. Improved method and kit for the generation of dna libraries for massively parallel sequencing
ES2959360T3 (es) 2017-07-26 2024-02-23 Univ Hong Kong Chinese Mejora del cribado del cáncer mediante ácidos nucleicos víricos acelulares
WO2019028462A1 (en) 2017-08-04 2019-02-07 Billiontoone, Inc. TARGET-ASSOCIATED MOLECULES FOR CHARACTERIZATION ASSOCIATED WITH BIOLOGICAL TARGETS
IL272399B2 (en) 2017-08-04 2025-03-01 Billiontoone Inc Sequencing output determination and analysis with target-associated molecules in quantification associated with biological targets
US11519024B2 (en) 2017-08-04 2022-12-06 Billiontoone, Inc. Homologous genomic regions for characterization associated with biological targets
CN120400338A (zh) 2017-08-07 2025-08-01 约翰斯霍普金斯大学 用于评估和治疗癌症的方法和材料
WO2019033079A1 (en) 2017-08-10 2019-02-14 City Of Hope CONDITIONAL RNAIDS AND THEIR USES IN THE TREATMENT OF CARDIAC HYPERTROPHY
WO2019060640A1 (en) 2017-09-20 2019-03-28 Guardant Health, Inc. METHODS AND SYSTEMS FOR DIFFERENTIATING SOMATIC VARIANTS AND GERMINAL LINE VARIANTS
CN107688726B (zh) * 2017-09-21 2021-09-07 深圳市易基因科技有限公司 基于液相捕获技术判定单基因病相关拷贝数缺失的方法
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
WO2019090147A1 (en) 2017-11-03 2019-05-09 Guardant Health, Inc. Correcting for deamination-induced sequence errors
WO2019090156A1 (en) 2017-11-03 2019-05-09 Guardant Health, Inc. Normalizing tumor mutation burden
ES2977793T3 (es) 2017-11-08 2024-08-30 Twinstrand Biosciences Inc Reactivos y adaptadores para la secuenciación de ácidos nucleicos y métodos para fabricar dichos reactivos y adaptadores
JP7054133B2 (ja) * 2017-11-09 2022-04-13 国立研究開発法人国立がん研究センター 配列解析方法、配列解析装置、参照配列の生成方法、参照配列生成装置、プログラム、および記録媒体
AU2018367488B2 (en) 2017-11-16 2021-09-16 Illumina, Inc. Systems and methods for determining microsatellite instability
JP2021503922A (ja) * 2017-11-28 2021-02-15 グレイル， インコーポレイテッドＧｒａｉｌ， Ｉｎｃ． ターゲットシーケンシングのためのモデル
EP3622522A1 (en) 2017-12-01 2020-03-18 Illumina, Inc. Methods and systems for determining somatic mutation clonality
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
WO2019118926A1 (en) 2017-12-14 2019-06-20 Tai Diagnostics, Inc. Assessing graft suitability for transplantation
CN108197428B (zh) * 2017-12-25 2020-06-19 西安交通大学 一种并行动态规划的下一代测序技术拷贝数变异检测方法
CN112365927B (zh) * 2017-12-28 2023-08-25 安诺优达基因科技(北京)有限公司 Cnv检测装置
SG11202006110UA (en) 2018-01-05 2020-07-29 Billiontoone Inc Quality control templates for ensuring validity of sequencing-based assays
US12590326B2 (en) 2018-01-10 2026-03-31 Guardant Health, Inc. Methods for fragmentome profiling of cell-free nucleic acids
EP3737774B1 (en) 2018-01-12 2024-12-25 Claret Bioscience, LLC Method for analyzing nucleic acid
EP3619653B1 (en) * 2018-01-15 2021-05-19 Illumina Inc. Deep learning-based variant classifier
CN108268752B (zh) * 2018-01-18 2019-02-01 东莞博奥木华基因科技有限公司 一种染色体异常检测装置
KR102036609B1 (ko) * 2018-02-12 2019-10-28 바이오코아 주식회사 디지털 pcr을 이용한 산전진단 방법
WO2019161244A1 (en) 2018-02-15 2019-08-22 Natera, Inc. Methods for isolating nucleic acids with size selection
WO2019178289A1 (en) 2018-03-13 2019-09-19 Grail, Inc. Method and system for selecting, managing, and analyzing data of high dimensionality
GB201804642D0 (en) * 2018-03-22 2018-05-09 Inivata Ltd Methods of labelling nucleic acids
US11203782B2 (en) 2018-03-29 2021-12-21 Accuragen Holdings Limited Compositions and methods comprising asymmetric barcoding
AU2019249422B2 (en) 2018-04-02 2025-09-25 Grail, Inc. Methylation markers and targeted methylation probe panels
JP7546486B2 (ja) 2018-04-13 2024-09-06 ガーダント ヘルス， インコーポレイテッド 融合事象によって引き起こされるアライメントエラーを検出および抑制する方法
DK3781714T3 (da) 2018-04-14 2026-03-30 Natera Inc Fremgangsmåder til cancerpåvisning og -overvågning ved personlig påvisning af cirkulerende tumor-dna
WO2019204208A1 (en) * 2018-04-16 2019-10-24 Memorial Sloan Kettering Cancer Center SYSTEMS AND METHODS FOR DETECTING CANCER VIA cfDNA SCREENING
JP7590954B2 (ja) * 2018-04-20 2024-11-27 バイオファイア・ダイアグノスティクス，リミテッド・ライアビリティ・カンパニー シーケンシングデータの正規化および定量化のための方法
EP3784806A4 (en) * 2018-04-24 2022-01-19 Grail, LLC SYSTEMS AND METHODS OF USING A PATHOGENIC NUCLEIC ACID LOAD TO DETERMINE IF A SUBJECT HAS A CANCER CONDITION
CN112888459B (zh) 2018-06-01 2023-05-23 格里尔公司 卷积神经网络系统及数据分类方法
JP2021526791A (ja) 2018-06-04 2021-10-11 ガーダント ヘルス， インコーポレイテッド セルフリー核酸の細胞起源を決定するための方法およびシステム
AU2019280712B2 (en) 2018-06-06 2025-11-20 The Regents Of The University Of California Methods of producing nucleic acid libraries and compositions and kits for practicing same
US12584163B2 (en) 2018-06-11 2026-03-24 Foundation Medicine, Inc. Compositions and methods for evaluating genomic alterations
CN109192246B (zh) * 2018-06-22 2020-10-16 深圳市达仁基因科技有限公司 检测染色体拷贝数异常的方法、装置和存储介质
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
US12073922B2 (en) 2018-07-11 2024-08-27 Illumina, Inc. Deep learning-based framework for identifying sequence patterns that cause sequence-specific errors (SSEs)
MX393603B (es) * 2018-07-11 2025-03-24 Illumina Inc Entorno basado en el aprendizaje profundo para la identificacion de patrones de secuencia que provocan errores especificos de secuencia (ees)
WO2020014693A1 (en) 2018-07-12 2020-01-16 Twinstrand Biosciences, Inc. Methods and reagents for characterizing genomic editing, clonal expansion, and associated applications
AU2019310041B2 (en) 2018-07-23 2025-11-20 Guardant Health, Inc. Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage
WO2020021119A1 (en) * 2018-07-27 2020-01-30 F. Hoffmann-La Roche Ag Method of monitoring effectiveness of immunotherapy of cancer patients
WO2020033425A1 (en) 2018-08-06 2020-02-13 Billiontoone, Inc. Dilution tagging for quantification of biological targets
CN113166750B (zh) 2018-08-10 2025-02-18 希望之城 可编程的条件性sirna及其用途
EP3841583A4 (en) * 2018-08-22 2022-05-18 The Regents of the University of California SENSITIVE DETECTION OF COPY NUMBER VARIATIONS (CNVS) FROM CIRCULATION-FREE NUCLEIC ACID
CA3109646A1 (en) 2018-08-30 2020-03-05 Guardant Health, Inc. Methods and systems for detecting contamination between samples
WO2020047553A1 (en) 2018-08-31 2020-03-05 Guardant Health, Inc. Genetic variant detection based on merged and unmerged reads
SG11202101400UA (en) 2018-08-31 2021-03-30 Guardant Health Inc Microsatellite instability detection in cell-free dna
JP7637615B2 (ja) 2018-09-04 2025-02-28 ガーダント ヘルス， インコーポレイテッド 無細胞核酸試料におけるアレル不均衡を検出するための方法およびシステム
EP3850631A1 (en) * 2018-09-14 2021-07-21 The Jackson Laboratory Method and apparatus for detecting copy number variations in a genome
IL281741B2 (en) 2018-09-27 2026-04-01 Grail Inc Methylation markers and a targeted methylation detection panel
EP3815005A4 (en) * 2018-10-08 2022-03-30 Freenome Holdings, Inc. Transcription factor profiling
CN109523520B (zh) * 2018-10-25 2020-12-18 北京大学第三医院 一种基于深度学习的染色体自动计数方法
EP3874060B1 (en) 2018-10-31 2024-10-16 Guardant Health, Inc. Method and system for calibrating epigenetic partitioning assays
EP4428234B1 (en) 2018-11-21 2025-12-24 Karius, Inc. Direct-to-library methods, systems, and compositions
CN109584961A (zh) * 2018-12-03 2019-04-05 元码基因科技（北京）股份有限公司 基于二代测序技术检测血液微卫星不稳定的方法
US11581062B2 (en) 2018-12-10 2023-02-14 Grail, Llc Systems and methods for classifying patients with respect to multiple cancer classes
US20200202975A1 (en) * 2018-12-19 2020-06-25 AiOnco, Inc. Genetic information processing system with mutation analysis mechanism and method of operation thereof
JP2022514010A (ja) 2018-12-20 2022-02-09 ガーダント ヘルス， インコーポレイテッド 核酸分子の回収率を改善するための方法、組成物、およびシステム
CN109712671B (zh) * 2018-12-20 2020-06-26 北京优迅医学检验实验室有限公司 基于ctDNA的基因检测装置、存储介质及计算机系统
CN111383714B (zh) * 2018-12-29 2023-07-28 安诺优达基因科技(北京)有限公司 模拟目标疾病仿真测序文库的方法及其应用
CA3126428A1 (en) 2019-01-31 2020-08-06 Guardant Health, Inc. Compositions and methods for isolating cell-free dna
CN109841265B (zh) * 2019-02-22 2021-09-21 清华大学 使用片段化模式确定血浆游离核酸分子组织来源的方法和系统及应用
KR20210132139A (ko) 2019-02-27 2021-11-03 가던트 헬쓰, 인크. 대립유전자 빈도에 기초한 기능 손실의 컴퓨터 모델링
WO2020176659A1 (en) 2019-02-27 2020-09-03 Guardant Health, Inc. Methods and systems for determining the cellular origin of cell-free dna
CN111755075B (zh) * 2019-03-28 2023-09-29 深圳华大生命科学研究院 对免疫组库高通量测序样本间序列污染进行过滤的方法
EP3947718A4 (en) 2019-04-02 2022-12-21 Enumera Molecular, Inc. METHODS, SYSTEMS AND COMPOSITIONS FOR COUNTING NUCLEIC ACID MOLECULES
EP3723096A1 (en) * 2019-04-12 2020-10-14 European Molecular Biology Laboratory Comprehensive detection of single cell genetic structural variations
US12497662B2 (en) 2019-04-16 2025-12-16 Grail, Inc. Systems and methods for tumor fraction estimation from small variants
CN110299185B (zh) * 2019-05-08 2023-07-04 西安电子科技大学 一种基于新一代测序数据的插入变异检测方法及系统
US11939636B2 (en) 2019-05-31 2024-03-26 Guardant Health, Inc. Methods and systems for improving patient monitoring after surgery
EP3980559A1 (en) 2019-06-06 2022-04-13 Natera, Inc. Methods for detecting immune cell dna and monitoring immune system
CN114585751A (zh) * 2019-06-12 2022-06-03 阿尔缇玛基因组学公司 使用分子条形码进行准确碱基判定的方法
US12437840B2 (en) 2019-07-02 2025-10-07 International Business Machines Corporation Determining cell, tissue, or lesion representations in cell-free DNA
CA3151538A1 (en) 2019-09-30 2021-04-08 Stefanie Ann Ward Mortimer Compositions and methods for analyzing cell-free dna in methylation partitioning assays
CN110578002A (zh) * 2019-10-10 2019-12-17 广州燃石医学检验所有限公司 用于检测循环肿瘤dna突变的质控品及其制备方法
MX2022004361A (es) * 2019-10-10 2022-05-03 Carlsberg As Metodos para preparar plantas mutantes.
EP4715839A2 (en) 2019-10-11 2026-03-25 Guardant Health, Inc. Use of cell free bacterial nucleic acids for detection of cancer
US11447819B2 (en) 2019-10-25 2022-09-20 Guardant Health, Inc. Methods for 3′ overhang repair
WO2021077411A1 (zh) * 2019-10-25 2021-04-29 苏州宏元生物科技有限公司 染色体不稳定性检测方法、系统及试剂盒
JP7411079B2 (ja) * 2019-10-25 2024-01-11 ソウル ナショナル ユニバーシティ アールアンドディービー ファウンデーション シーケンシングプラットフォームの特異的エラーを減らした体細胞突然変異検出装置及び方法
GB2623904B (en) 2019-11-06 2024-07-24 Univ Leland Stanford Junior Methods and systems for analyzing nucleic acid molecules
CN114746560A (zh) 2019-11-26 2022-07-12 夸登特健康公司 改进甲基化多核苷酸结合的方法、组合物和系统
KR102184277B1 (ko) * 2020-01-16 2020-11-30 성균관대학교산학협력단 초음파 진단 및 dna 검사 일체형 ai 자가 건강 관리 장치 및 이를 이용한 원격 의료 진단 방법
EP3851542A1 (en) 2020-01-20 2021-07-21 Tecan Genomics, Inc. Depletion of abundant uninformative sequences
JP7763764B2 (ja) 2020-01-31 2025-11-04 ガーダント ヘルス， インコーポレイテッド 標的バリアントがクローンレベルで存在しないことの有意性モデリング
CN113275053A (zh) 2020-02-03 2021-08-20 帝肯基因组学公司 试剂存储系统
IL295297A (en) 2020-02-14 2022-10-01 Univ Johns Hopkins Methods and materials for assessing nucleic acids
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
JP7813712B2 (ja) 2020-03-11 2026-02-13 ガーダント ヘルス， インコーポレイテッド 無細胞核酸において検出された遺伝的突然変異を、腫瘍起源または非腫瘍起源として分類するための方法
CN111445950B (zh) * 2020-03-19 2022-10-25 西安交通大学 一种基于滤波策略的高容错基因组复杂结构变异检测方法
CN113436679B (zh) * 2020-03-23 2024-05-10 北京合生基因科技有限公司 确定待测核酸样本变异率的方法和系统
CA3177127A1 (en) 2020-04-30 2021-11-04 Guardant Health, Inc. Methods for sequence determination using partitioned nucleic acids
US12241126B2 (en) 2020-05-14 2025-03-04 Guardant Health, Inc. Homologous recombination repair deficiency detection
US20230183811A1 (en) * 2020-05-14 2023-06-15 Georgia Tech Research Corporation Methods of detecting the efficacy of anticancer agents
US12467096B2 (en) 2020-05-15 2025-11-11 Universal Diagnostics, S.A. Methods and systems for identifying methylation biomarkers
US12592321B2 (en) * 2020-06-19 2026-03-31 University Health Network Cancer detection and classification using methylome analysis
WO2023282916A1 (en) 2021-07-09 2023-01-12 Guardant Health, Inc. Methods of detecting genomic rearrangements using cell free nucleic acids
EP4179111B1 (en) 2020-07-10 2024-04-03 Guardant Health, Inc. Methods of detecting genomic rearrangements using cell free nucleic acids
WO2022026761A1 (en) 2020-07-30 2022-02-03 Guardant Health, Inc. Methods for isolating cell-free dna
WO2022046947A1 (en) 2020-08-25 2022-03-03 Guardant Health, Inc. Methods and systems for predicting an origin of a variant
JP2023540904A (ja) 2020-08-25 2023-09-27 シアー， インコーポレイテッド タンパク質および核酸をアッセイするための組成物および方法
EP4205122A2 (en) 2020-08-27 2023-07-05 Guardant Health, Inc. Computational detection of copy number variation at a locus in the absence of direct measurement of the locus
WO2022073012A1 (en) 2020-09-30 2022-04-07 Guardant Health, Inc. Compositions and methods for analyzing dna using partitioning and a methylation-dependent nuclease
WO2022087309A1 (en) 2020-10-23 2022-04-28 Guardant Health, Inc. Compositions and methods for analyzing dna using partitioning and base conversion
CA3199829A1 (en) 2020-11-30 2022-06-02 Guardant Health, Inc. Compositions and methods for enriching methylated polynucleotides
WO2022140629A1 (en) 2020-12-23 2022-06-30 Guardant Health, Inc. Methods and systems for analyzing methylated polynucleotides
CN116583906A (zh) * 2020-12-28 2023-08-11 松下电器（美国）知识产权公司 信息处理方法、信息处理装置以及信息处理程序
CN112735516A (zh) * 2020-12-29 2021-04-30 上海派森诺生物科技股份有限公司 一种无参考基因组的群体变异检测分析方法
CN112908411B (zh) * 2021-01-12 2024-05-14 广州市金域转化医学研究院有限公司 一种线粒体变异位点数据库及其建立方法和应用
EP4729633A2 (en) 2021-02-12 2026-04-22 Guardant Health, Inc. Methods for detecting nucleic acid variants
JP2024513668A (ja) 2021-03-05 2024-03-27 ガーダント ヘルス， インコーポレイテッド 分子応答を分析するための方法および関連する態様
WO2022192889A1 (en) 2021-03-09 2022-09-15 Guardant Health, Inc. Detecting the presence of a tumor based on off-target polynucleotide sequencing data
EP4314329A1 (en) 2021-03-25 2024-02-07 Guardant Health, Inc. Methods and compositions for quantifying immune cell dna
CN113130005B (zh) * 2021-04-12 2022-11-22 中国科学院东北地理与农业生态研究所 一种基于m2群体的候选因果突变位点基因定位的方法
US11783912B2 (en) 2021-05-05 2023-10-10 The Board Of Trustees Of The Leland Stanford Junior University Methods and systems for analyzing nucleic acid molecules
WO2022251655A1 (en) 2021-05-28 2022-12-01 Guardant Health, Inc. Compositions and methods for assaying circulating molecules
CN113284555B (zh) * 2021-06-11 2023-08-22 中山大学 一种基因突变网络的构建方法、装置、设备及存储介质
EP4359562A1 (en) 2021-06-21 2024-05-01 Guardant Health, Inc. Methods and compositions for copy-number informed tissue-of-origin analysis
WO2023283551A1 (en) * 2021-07-06 2023-01-12 Switch Therapeutics Inc. Methods of designing conditional-activatable small interfering rna sensors
WO2023018791A1 (en) * 2021-08-10 2023-02-16 Cornell University Ultra-sensitive liquid biopsy through deep learning empowered whole genome sequencing of plasma
WO2023056065A1 (en) 2021-09-30 2023-04-06 Guardant Health, Inc. Compositions and methods for synthesis and use of probes targeting nucleic acid rearrangements
AU2022359420A1 (en) * 2021-10-04 2024-05-02 Grail, Llc Sequencing of viral dna for predicting disease relapse
JP2024540168A (ja) 2021-11-02 2024-10-31 ガーダント ヘルス， インコーポレイテッド 品質管理方法
WO2023097325A2 (en) * 2021-11-29 2023-06-01 Mammoth Biosciences, Inc. Systems and methods for identifying genetic phenotypes using programmable nucleases
CN114703263B (zh) * 2021-12-20 2023-09-22 北京科迅生物技术有限公司 一种群组染色体拷贝数变异检测方法及装置
EP4453241A1 (en) 2021-12-21 2024-10-30 Guardant Health, Inc. Methods and systems for combinatorial chromatin-ip sequencing
WO2023122740A1 (en) 2021-12-23 2023-06-29 Guardant Health, Inc. Compositions and methods for detection of metastasis
AU2023240345A1 (en) 2022-03-21 2024-10-10 Billion Toone, Inc. Molecule counting of methylated cell-free dna for treatment monitoring
EP4504971A1 (en) 2022-04-07 2025-02-12 Guardant Health, Inc. Detecting the presence of a tumor based on methylation status of cell-free nucleic acid molecules
CN114724628B (zh) * 2022-04-24 2022-11-08 华中农业大学 一种对多物种进行多核苷酸变异鉴定和注释的方法
EP4523213A1 (en) 2022-05-09 2025-03-19 Guardant Health, Inc. Detecting degradation based on strand bias
EP4547857A1 (en) 2022-06-30 2025-05-07 Guardant Health, Inc. Enrichment of aberrantly methylated dna
CN119923475A (zh) 2022-07-21 2025-05-02 夸登特健康公司 用于检测和减少样品制备诱导的甲基化人为假象的方法
JP2025532567A (ja) 2022-09-16 2025-10-01 ガーダント ヘルス， インコーポレイテッド 可溶性タンパク質を解析するための組成物および方法
WO2024073508A2 (en) 2022-09-27 2024-04-04 Guardant Health, Inc. Methods and compositions for quantifying immune cell dna
KR20250110272A (ko) 2022-11-15 2025-07-18 가던트 헬쓰, 인크. 순환 종양 dna (ctdna)로부터 기준선 ctdna 수준 및 시간 경과에 따른 ctdna 수준의 종단적 변화 둘 다로부터의 신호를 이용하여 비소세포 폐암 (nsclc) 환자 약물 반응 또는 사망 또는 암 진행까지의 시간을 예측하는 방법
US12606872B2 (en) 2022-11-16 2026-04-21 Universal Diagnostics, S.A. Methods for stratification and early detection of advanced adenoma and/or colorectal cancer using DNA methylation markers
CN120226085A (zh) 2022-11-17 2025-06-27 夸登特健康公司 用于在无细胞dna液体活检测定中对非肿瘤变异进行分类的生物信息学模型的验证
KR20250138733A (ko) 2022-12-21 2025-09-22 가던트 헬쓰, 인크. 세포-유리 핵산 분자의 메틸화 상태에 기초한 상동 재조합 결핍의 검출
WO2024138180A2 (en) 2022-12-22 2024-06-27 Guardant Health, Inc. Integrated targeted and whole genome somatic and dna methylation sequencing workflows
EP4638781A2 (en) 2022-12-22 2025-10-29 Guardant Health, Inc. Methods involving methylation preserving amplification with error correction
JP2026505886A (ja) 2023-01-11 2026-02-19 ガーダント ヘルス， インコーポレイテッド 患者生存を予測するための縦断データおよびイベント発生までの時間データのジョイントモデリング
EP4655416A1 (en) 2023-01-25 2025-12-03 Guardant Health, Inc. Nucleic acid methylation profiling method
CN115798580B (zh) * 2023-02-10 2023-11-07 北京中仪康卫医疗器械有限公司 基于基因型填补和低深度测序的一体化基因组分析方法
US20250078955A1 (en) 2023-04-07 2025-03-06 Guardant Health, Inc. Detecting the presence of a tumor based on methylation status of cell-free nucleic acid molecules
CN121079437A (zh) 2023-04-12 2025-12-05 夸登特健康公司 启动子甲基化检测
WO2024229143A1 (en) 2023-05-01 2024-11-07 Guardant Health, Inc. Quality control method for enzymatic conversion procedures
EP4705508A1 (en) 2023-05-03 2026-03-11 Guardant Health, Inc. Methods for analysis of dna methylation
EP4705522A1 (en) 2023-05-05 2026-03-11 Guardant Health, Inc. Cell-free dna blood-based test for cancer screening
WO2024259251A1 (en) 2023-06-15 2024-12-19 Guardant Health, Inc. Method for hrd detection in targeted cfdna samples using de novo mutational signatures
WO2024264065A1 (en) 2023-06-23 2024-12-26 Guardant Health, Inc. Methods and compositions for quantifying immune cell nucleic acids
EP4735890A1 (en) 2023-06-29 2026-05-06 Guardant Health, Inc. Methods for determining surveillance and therapy for diseases
WO2025029475A1 (en) 2023-07-28 2025-02-06 Guardant Health, Inc. Methods to enrich nucleotide variants by negative selection
WO2025038399A1 (en) 2023-08-11 2025-02-20 Guardant Health, Inc. Methylated enrichment methods for single-molecule genetic and epigenetic sequencing
US20250084469A1 (en) 2023-09-12 2025-03-13 Guardant Health, Inc. Methods for analyzing nucleic acids using sequence read family size distribution
WO2025064706A1 (en) 2023-09-19 2025-03-27 Guardant Health, Inc. Detecting the presence of a tumor based on methylation status of cell-free nucleic acid molecules
US20250246266A1 (en) 2023-09-29 2025-07-31 Guardant Health, Inc. Genotyping cyp2d6
US20250250638A1 (en) 2023-10-06 2025-08-07 Guardant Health, Inc. Genomic and methylation biomarkers for prediction of copy number loss / gene deletion
WO2025076452A1 (en) 2023-10-06 2025-04-10 Guardant Health, Inc. Detecting tumor-related information based on methylation status of cell-free nucleic acid molecules
WO2025079958A1 (ko) * 2023-10-11 2025-04-17 고려대학교 산학협력단 높은 처리량의 돌연변이 특이적 아답터 리게이션 방법
WO2025085784A1 (en) 2023-10-18 2025-04-24 Guardant Health, Inc. Genomic and methylation biomarkers for determining patient risk of heart disease and novel genomic and epigenomic drug targets to decrease risk of heart disease and/or improve patient outcome after myocardial infarction or cardiac injury
WO2025090956A1 (en) 2023-10-26 2025-05-01 Guardant Health, Inc. Methods for detecting nucleic acid variants using capture probes
WO2025090954A1 (en) 2023-10-26 2025-05-01 Guardant Health, Inc. Methods for detecting nucleic acid variants
WO2025090646A1 (en) 2023-10-27 2025-05-01 Guardant Health, Inc. Monitoring molecular response by allelic imbalance
WO2025106275A1 (en) 2023-11-15 2025-05-22 Guardant Health, Inc. Minimum residual disease (mrd) detection in early stage cancer using urine
WO2025106263A1 (en) 2023-11-15 2025-05-22 Guardant Health, Inc. Joint modeling of longitudinal and time-to-event data to predict patient survival
WO2025137620A1 (en) 2023-12-21 2025-06-26 Guardant Health, Inc. Methods for high quality and high accuracy methylation sequencing
WO2025137389A2 (en) 2023-12-22 2025-06-26 Guardant Health, Inc. Methods for targeted single-molecule genetic and epigenetic sequencing
WO2025160433A1 (en) * 2024-01-24 2025-07-31 Guardant Health, Inc. Methods for analyzing sequencing reads
WO2025207817A1 (en) 2024-03-26 2025-10-02 Guardant Health, Inc. Method of determining the likelihood of a disease by combining biomarkers and imaging
US20250308636A1 (en) 2024-03-27 2025-10-02 Guardant Health, Inc. Inferring cnvs from the distribution of molecules in hyper partition
WO2025208044A1 (en) 2024-03-28 2025-10-02 Guardant Health, Inc. Methods for cancer detection using molecular patterns
WO2025207941A1 (en) 2024-03-28 2025-10-02 Guardant Health, Inc. Methods for separating cpg-dense dna by binding of cpg-binding proteins and methyl-sensitive deamination
US20250308629A1 (en) 2024-04-01 2025-10-02 Guardant Health, Inc. Small variant calling with error-rate based model
WO2025235602A1 (en) 2024-05-07 2025-11-13 Guardant Health, Inc. Predictive, prognostic signatures for immuno-oncology using liquid biopsy
WO2025235889A1 (en) 2024-05-10 2025-11-13 Guardant Health, Inc. Methods involving multiplexed pooled pcr
WO2025245131A1 (en) * 2024-05-21 2025-11-27 SAGA Dx, Inc. Tumor marker selection and detection
WO2025250544A1 (en) 2024-05-31 2025-12-04 Guardant Health, Inc. Methods for analyzing chromatin architecture in tissue to boost detection of cancer associated signals in cell-free dna
US12467087B1 (en) 2024-06-25 2025-11-11 Guardant Health, Inc. Sequencing methods with partitioning
WO2026015607A1 (en) 2024-07-09 2026-01-15 Guardant Health, Inc. Methods for partitioning hyper-, hypo-, and non-methylated dna
WO2026015794A1 (en) 2024-07-12 2026-01-15 Guardant Health, Inc. Methods for modifying dna using cpg-specific deamination and uracil base excision
WO2026024817A1 (en) 2024-07-24 2026-01-29 Guardant Health, Inc. Methods and compositions for anchored multiplex ngs workflows
WO2026024956A1 (en) 2024-07-24 2026-01-29 Guardant Health, Inc. Selecting low technical noise biomarkers for sensitive molecular diagnostics
WO2026024692A1 (en) 2024-07-24 2026-01-29 Guardant Health, Inc. Direct methylation single-base resolution sequencing of enriched unmethylated dna
WO2026043702A1 (en) 2024-08-21 2026-02-26 Guardant Health, Inc. Methods and approaches for personalized identification and monitoring of extrachromosomal circular dna
WO2026043718A1 (en) 2024-08-21 2026-02-26 Guardant Health, Inc. Methods to monitor patients treated with a cancer vaccine
WO2026050179A1 (en) 2024-08-26 2026-03-05 Guardant Health, Inc. Tumor fraction (tf) is associated with real-world progression-free survival (rwpfs) in non-small-cell lung cancer (nsclc) patients treated with platinum-based chemotherapy (chemo)
WO2026050287A1 (en) 2024-08-27 2026-03-05 Guardant Health, Inc. Methylation biomarkers for osimertinib treatment management
WO2026060266A1 (en) 2024-09-13 2026-03-19 Guardant Health, Inc. Use of copy number variants for the identification of false positive tumor calls
WO2026064529A2 (en) 2024-09-18 2026-03-26 Guardant Health, Inc. Methods for detecting nucleic acid variants using primers and ligation substrates
WO2026073140A1 (en) 2024-09-27 2026-04-02 Guardant Health, Inc. Framework to identify genomic regions indicative of one or more biological conditions
WO2026076332A1 (en) 2024-10-03 2026-04-09 Guardant Health, Inc. Methods involving multi-modal tumor variant identification and tracking of tumor molecules
WO2026080838A2 (en) 2024-10-11 2026-04-16 Guardant Health, Inc. Methods for detecting nucleic acid variants
WO2026090570A1 (en) 2024-10-24 2026-04-30 Guardant Health, Inc. Detecting the presence of a biological condition based on a nucleic acid sample data analysis
WO2026096358A1 (en) 2024-10-28 2026-05-07 Guardant Health, Inc. Screening approaches for high cancer risk individuals
WO2026096657A1 (en) 2024-10-29 2026-05-07 Guardant Health, Inc. Methods for highly multi-plexed detection and quantification of co-localized membrane surface proteins
WO2026096627A1 (en) 2024-10-29 2026-05-07 Guardant Health, Inc. Methods for high-plexity extracellular vesicle protein characterization through immunopcr/ngs

Family Cites Families (279)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US604804A (en) * 1898-05-31 Shuttle for looms
US4725536A (en) 1985-09-19 1988-02-16 Genetics Institute, Inc. Reagent polynucleotide complex with multiple target binding regions, and kit and methods
US6150517A (en) 1986-11-24 2000-11-21 Gen-Probe Methods for making oligonucleotide probes for the detection and/or quantitation of non-viral organisms
US5149625A (en) 1987-08-11 1992-09-22 President And Fellows Of Harvard College Multiplex analysis of DNA
US4942124A (en) 1987-08-11 1990-07-17 President And Fellows Of Harvard College Multiplex sequencing
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5656731A (en) 1987-10-15 1997-08-12 Chiron Corporation Nucleic acid-amplified immunoassay probes
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6309822B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5925525A (en) 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5871928A (en) 1989-06-07 1999-02-16 Fodor; Stephen P. A. Methods for nucleic acid analysis
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5200314A (en) 1990-03-23 1993-04-06 Chiron Corporation Polynucleotide capture assay employing in vitro amplification
US6582908B2 (en) 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
WO1992010588A1 (en) 1990-12-06 1992-06-25 Affymax Technologies N.V. Sequencing by hybridization of a target nucleic acid to a matrix of defined oligonucleotides
US5981179A (en) 1991-11-14 1999-11-09 Digene Diagnostics, Inc. Continuous amplification reaction
US5424413A (en) 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US6020124A (en) 1992-04-27 2000-02-01 Trustees Of Dartmouth College Detection of soluble gene sequences in biological fluids
US5981176A (en) 1992-06-17 1999-11-09 City Of Hope Method of detecting and discriminating between nucleic acid sequences
DE69431719T2 (de) 1993-06-25 2003-09-18 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Hybridisierung und sequenzierung von nukleinsäuren
US5500356A (en) 1993-08-10 1996-03-19 Life Technologies, Inc. Method of nucleic acid sequence selection
US6309823B1 (en) 1993-10-26 2001-10-30 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same
US5681697A (en) 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
CH686982A5 (fr) 1993-12-16 1996-08-15 Maurice Stroun Méthode pour le diagnostic de cancers.
US20030017081A1 (en) 1994-02-10 2003-01-23 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5714330A (en) 1994-04-04 1998-02-03 Lynx Therapeutics, Inc. DNA sequencing by stepwise ligation and cleavage
US6013445A (en) 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US5695934A (en) 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
US5846719A (en) 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US6600996B2 (en) 1994-10-21 2003-07-29 Affymetrix, Inc. Computer-aided techniques for analyzing biological sequences
DE69535240T2 (de) 1994-10-28 2007-06-06 Gen-Probe Inc., San Diego Zusammensetzungen und Verfahren für die gleichzeitige Detektion und Quantifizierung von einer Mehrheit spezifischer Nuklein Säure Sequenzen
US5648245A (en) 1995-05-09 1997-07-15 Carnegie Institution Of Washington Method for constructing an oligonucleotide concatamer library by rolling circle replication
US5968740A (en) 1995-07-24 1999-10-19 Affymetrix, Inc. Method of Identifying a Base in a Nucleic Acid
GB9516636D0 (en) 1995-08-14 1995-10-18 Univ London In-situ nucleic acid amplification and detection
US5763175A (en) 1995-11-17 1998-06-09 Lynx Therapeutics, Inc. Simultaneous sequencing of tagged polynucleotides
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US6156504A (en) 1996-03-15 2000-12-05 The Penn State Research Foundation Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays
ES2347854T5 (es) 1996-03-26 2014-07-24 Michael S. Kopreski Método que permite el uso de RNA extracelular extraído de plasma o suero para detectar, monitorizar o evaluar un cáncer
US6458530B1 (en) 1996-04-04 2002-10-01 Affymetrix Inc. Selecting tag nucleic acids
US6300077B1 (en) 1996-08-14 2001-10-09 Exact Sciences Corporation Methods for the detection of nucleic acids
WO1998015644A2 (en) 1996-09-27 1998-04-16 The Chinese University Of Hong Kong Parallel polynucleotide sequencing method
US6124092A (en) 1996-10-04 2000-09-26 The Perkin-Elmer Corporation Multiplex polynucleotide capture methods and compositions
US6117631A (en) 1996-10-29 2000-09-12 Polyprobe, Inc. Detection of antigens via oligonucleotide antibody conjugates
US6046005A (en) 1997-01-15 2000-04-04 Incyte Pharmaceuticals, Inc. Nucleic acid sequencing with solid phase capturable terminators comprising a cleavable linking group
EP0985142A4 (en) 1997-05-23 2006-09-13 Lynx Therapeutics Inc SYSTEM AND APPARATUS FOR THE SEQUENTIAL TREATMENT OF ANALYTES
WO1999028505A1 (en) 1997-12-03 1999-06-10 Curagen Corporation Methods and devices for measuring differential gene expression
EP1114148A4 (en) 1998-08-28 2004-12-22 Invitrogen Corp SYSTEM FOR RAPID HANDLING OF NUCLEIC ACID SEQUENCES
US6653077B1 (en) 1998-09-04 2003-11-25 Lynx Therapeutics, Inc. Method of screening for genetic polymorphism
US6503718B2 (en) 1999-01-10 2003-01-07 Exact Sciences Corporation Methods for detecting mutations using primer extension for detecting disease
CA2360929A1 (en) 1999-02-05 2000-08-10 Amersham Pharmacia Biotech Uk Limited Genomic analysis method
US6629040B1 (en) 1999-03-19 2003-09-30 University Of Washington Isotope distribution encoded tags for protein identification
EP1165839A2 (en) 1999-03-26 2002-01-02 Whitehead Institute For Biomedical Research Universal arrays
DE60029092T2 (de) 1999-04-09 2007-02-01 Exact Sciences Corp., Marlborough Verfahren zur detektion von nukleinsäuren, welche auf krebs hinweisen
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
DE60045059D1 (de) 1999-04-20 2010-11-18 Nat Inst Of Advanced Ind Scien Verfahren und Sonden zur Bestimmung der Konzentration von Nukleinsäure-Molekülen und Verfahren zur Analyse der gewonnenen Daten
US6242186B1 (en) 1999-06-01 2001-06-05 Oy Jurilab Ltd. Method for detecting a risk of cancer and coronary heart disease and kit therefor
US6326148B1 (en) 1999-07-12 2001-12-04 The Regents Of The University Of California Detection of copy number changes in colon cancer
US6440706B1 (en) 1999-08-02 2002-08-27 Johns Hopkins University Digital amplification
US6586177B1 (en) 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
US6849403B1 (en) 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
DE60043896D1 (de) 1999-12-07 2010-04-08 Exact Sciences Corp Verfahren zum nachweis von lungenneoplasmen in fäkalen proben
US6489114B2 (en) 1999-12-17 2002-12-03 Bio Merieux Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby
AU2001238068A1 (en) 2000-02-07 2001-08-14 Illumina, Inc. Nucleic acid detection methods using universal priming
GB2364054B (en) 2000-03-24 2002-05-29 Smithkline Beecham Corp Method of amplifying quinolone-resistance-determining-regions and identifying polymorphic variants thereof
US20030207300A1 (en) 2000-04-28 2003-11-06 Matray Tracy J. Multiplex analytical platform using molecular tags
EP1158055A1 (fr) 2000-05-26 2001-11-28 Xu Qi University of Teaxs Laboratoire de Leucémie Chen Méthode pour le diagnostic de cancers
EP1366192B8 (en) 2000-10-24 2008-10-29 The Board of Trustees of the Leland Stanford Junior University Direct multiplex characterization of genomic dna
US20020142345A1 (en) 2000-12-22 2002-10-03 Nelsen Anita J. Methods for encoding and decoding complex mixtures in arrayed assays
US20030049616A1 (en) 2001-01-08 2003-03-13 Sydney Brenner Enzymatic synthesis of oligonucleotide tags
US6428964B1 (en) 2001-03-15 2002-08-06 Exact Sciences Corporation Method for alteration detection
US6849404B2 (en) 2001-05-07 2005-02-01 Bioneer Corporation Polymerase chain reaction of DNA of which base sequence is completely unidentified
US7406385B2 (en) 2001-10-25 2008-07-29 Applera Corporation System and method for consensus-calling with per-base quality values for sample assemblies
ES2253461T3 (es) 2002-03-05 2006-06-01 Epigenomics Ag Procedimiento y dispositivo para la determinacion de la especificidad del tejido y del adn que flota libre en tejidos corporales.
US20030186251A1 (en) 2002-04-01 2003-10-02 Brookhaven Science Associates, Llc Genome sequence tags
US7727720B2 (en) 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
AU2003291481A1 (en) 2002-11-11 2004-06-03 Affymetrix, Inc. Methods for identifying dna copy number changes
US10229244B2 (en) 2002-11-11 2019-03-12 Affymetrix, Inc. Methods for identifying DNA copy number changes using hidden markov model based estimations
US7822555B2 (en) 2002-11-11 2010-10-26 Affymetrix, Inc. Methods for identifying DNA copy number changes
US7704687B2 (en) 2002-11-15 2010-04-27 The Johns Hopkins University Digital karyotyping
EP1606417A2 (en) 2003-03-07 2005-12-21 Rubicon Genomics Inc. In vitro dna immortalization and whole genome amplification using libraries generated from randomly fragmented dna
WO2006102264A1 (en) 2005-03-18 2006-09-28 Fluidigm Corporation Thermal reaction device and method for using the same
US20040259118A1 (en) 2003-06-23 2004-12-23 Macevicz Stephen C. Methods and compositions for nucleic acid sequence analysis
CA2531105C (en) 2003-07-05 2015-03-17 The Johns Hopkins University Method and compositions for detection and enumeration of genetic variations
DE60328193D1 (de) 2003-10-16 2009-08-13 Sequenom Inc Nicht invasiver Nachweis fötaler genetischer Merkmale
DE10348407A1 (de) 2003-10-17 2005-05-19 Widschwendter, Martin, Prof. Prognostische und diagnostische Marker für Zell-proliferative Erkrankungen von Brustgeweben
US20070111233A1 (en) 2003-10-30 2007-05-17 Bianchi Diana W Prenatal diagnosis using cell-free fetal DNA in amniotic fluid
CA2552858A1 (en) 2004-01-23 2005-08-04 Lingvitae As Improving polynucleotide ligation reactions
AU2005214329A1 (en) 2004-02-12 2005-09-01 Population Genetics Technologies Ltd Genetic analysis by sequence-specific sorting
US20100216153A1 (en) 2004-02-27 2010-08-26 Helicos Biosciences Corporation Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities
US20060046258A1 (en) 2004-02-27 2006-03-02 Lapidus Stanley N Applications of single molecule sequencing
WO2005111242A2 (en) 2004-05-10 2005-11-24 Parallele Bioscience, Inc. Digital profiling of polynucleotide populations
US7276720B2 (en) 2004-07-19 2007-10-02 Helicos Biosciences Corporation Apparatus and methods for analyzing samples
US20060035258A1 (en) 2004-08-06 2006-02-16 Affymetrix, Inc. Methods for identifying DNA copy number changes
US7937225B2 (en) 2004-09-03 2011-05-03 New York University Systems, methods and software arrangements for detection of genome copy number variation
US20060073506A1 (en) 2004-09-17 2006-04-06 Affymetrix, Inc. Methods for identifying biological samples
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence
US7424371B2 (en) 2004-12-21 2008-09-09 Helicos Biosciences Corporation Nucleic acid analysis
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
ITRM20050068A1 (it) 2005-02-17 2006-08-18 Istituto Naz Per Le Malattie I Metodo per la rivelazione di acidi nucleici di agenti patogeni batterici o di parassiti nelle urine.
WO2006099604A2 (en) 2005-03-16 2006-09-21 Compass Genetics, Llc Methods and compositions for assay readouts on multiple analytical platforms
ES2313143T3 (es) 2005-04-06 2009-03-01 Maurice Stroun Metodo para el diagnostico de cancer mediante la deteccion de adn y arn circulantes.
US20070020640A1 (en) 2005-07-21 2007-01-25 Mccloskey Megan L Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
CA2910861C (en) 2005-09-29 2018-08-07 Michael Josephus Theresia Van Eijk High throughput screening of mutagenized populations
WO2007087312A2 (en) * 2006-01-23 2007-08-02 Population Genetics Technologies Ltd. Molecular counting
US20070172839A1 (en) 2006-01-24 2007-07-26 Smith Douglas R Asymmetrical adapters and methods of use thereof
US8383338B2 (en) 2006-04-24 2013-02-26 Roche Nimblegen, Inc. Methods and systems for uniform enrichment of genomic regions
US7702468B2 (en) 2006-05-03 2010-04-20 Population Diagnostics, Inc. Evaluating genetic disorders
WO2007137187A2 (en) 2006-05-18 2007-11-29 Molecular Profiling Institute, Inc. System and method for determining individualized medical intervention for a disease state
US20080124721A1 (en) 2006-06-14 2008-05-29 Martin Fuchs Analysis of rare cell-enriched samples
FR2904833A1 (fr) 2006-08-11 2008-02-15 Bioquanta Sarl Procede de dosage d'acide nuclieque par fluorescence
EP2518162B1 (en) 2006-11-15 2018-03-07 Biospherex LLC Multitag sequencing and ecogenomics analysis
WO2008070144A2 (en) 2006-12-06 2008-06-12 Duke University Imprinted genes and disease
EP2126127B1 (en) 2007-01-25 2016-09-28 Dana-Farber Cancer Institute, Inc. Use of anti-egfr antibodies in treatment of egfr mutant mediated disease
DK2465950T3 (en) 2007-03-13 2017-10-09 Amgen Inc K-RAS MUTATIONS AND ANTI-EGFR ANTIBODY TREATMENT
WO2008148072A2 (en) 2007-05-24 2008-12-04 The Brigham And Women's Hospital, Inc. Disease-associated genetic variations and methods for obtaining and using same
WO2008150432A1 (en) 2007-06-01 2008-12-11 454 Life Sciences Corporation System and meth0d for identification of individual samples from a multiplex mixture
US8182993B2 (en) * 2007-06-06 2012-05-22 Pacific Biosciences Of California, Inc. Methods and processes for calling bases in sequence by incorporation methods
HUE061020T2 (hu) 2007-07-23 2023-05-28 Univ Hong Kong Chinese Nukleinsav-szekvencia kiegyensúlyozatlanságának meghatározására
US12180549B2 (en) 2007-07-23 2024-12-31 The Chinese University Of Hong Kong Diagnosing fetal chromosomal aneuploidy using genomic sequencing
US20090053719A1 (en) 2007-08-03 2009-02-26 The Chinese University Of Hong Kong Analysis of nucleic acids by digital pcr
JP5707132B2 (ja) 2007-09-07 2015-04-22 フルイダイム コーポレイション コピー数変動の決定、方法およびシステム
US20100173294A1 (en) 2007-09-11 2010-07-08 Roche Molecular Systems, Inc. Diagnostic test for susceptibility to b-raf kinase inhibitors
JP5643650B2 (ja) 2007-11-21 2014-12-17 コスモシド・インコーポレーテッド ゲノム同定システム
BRPI0908128A2 (pt) 2008-02-12 2015-08-04 Novartis Ag Método para isolamento de ácido nucleicos apoptóticos ou fetais livres de células
US8216789B2 (en) 2008-02-27 2012-07-10 University Of Washington Diagnostic panel of cancer antibodies and methods for use
US20110003701A1 (en) 2008-02-27 2011-01-06 454 Life Sciences Corporation System and method for improved processing of nucleic acids for production of sequencable libraries
US8206926B2 (en) 2008-03-26 2012-06-26 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
EP3269824A1 (en) 2008-03-28 2018-01-17 Pacific Biosciences Of California, Inc. Compositions and methods for nucleic acid sequencing
WO2009143379A2 (en) 2008-05-21 2009-11-26 Fred Hutchinson Cancer Research Center Use of extracellular rna to measure disease
US20090298709A1 (en) 2008-05-28 2009-12-03 Affymetrix, Inc. Assays for determining telomere length and repeated sequence copy number
DE102008025656B4 (de) 2008-05-28 2016-07-28 Genxpro Gmbh Verfahren zur quantitativen Analyse von Nukleinsäuren, Marker dafür und deren Verwendung
CN102165073A (zh) 2008-07-10 2011-08-24 骆树恩 用于核酸作图和鉴定核酸中的精细结构变化的方法
US20100041048A1 (en) 2008-07-31 2010-02-18 The Johns Hopkins University Circulating Mutant DNA to Assess Tumor Dynamics
US20100062494A1 (en) 2008-08-08 2010-03-11 President And Fellows Of Harvard College Enzymatic oligonucleotide pre-adenylation
WO2010021936A1 (en) 2008-08-16 2010-02-25 The Board Of Trustees Of The Leland Stanford Junior University Digital pcr calibration for high throughput sequencing
US8583380B2 (en) 2008-09-05 2013-11-12 Aueon, Inc. Methods for stratifying and annotating cancer drug treatment options
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
ES2620012T3 (es) 2008-09-20 2017-06-27 The Board Of Trustees Of The Leland Stanford Junior University Diagnóstico no invasivo de la aneuploidia fetal por secuenciación
EP2607496B1 (en) 2008-12-23 2014-07-16 Illumina, Inc. Methods useful in nucleic acid sequencing protocols
ES2403312T3 (es) 2009-01-13 2013-05-17 Keygene N.V. Nuevas estrategias para la secuenciación del genoma
US20100323348A1 (en) 2009-01-31 2010-12-23 The Regents Of The University Of Colorado, A Body Corporate Methods and Compositions for Using Error-Detecting and/or Error-Correcting Barcodes in Nucleic Acid Amplification Process
US20120165202A1 (en) 2009-04-30 2012-06-28 Good Start Genetics, Inc. Methods and compositions for evaluating genetic markers
WO2010127186A1 (en) 2009-04-30 2010-11-04 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
US20130143747A1 (en) 2011-12-05 2013-06-06 Myriad Genetics, Incorporated Methods of detecting cancer
US9524369B2 (en) 2009-06-15 2016-12-20 Complete Genomics, Inc. Processing and analysis of complex nucleic acid sequence data
RU2014144463A (ru) 2009-06-25 2015-06-20 Фред Хатчинсон Кансэр Рисёч Сентер Способ измерения адаптивного иммунитета
EP2456885A2 (en) 2009-07-20 2012-05-30 Bar Harbor Biotechnology, Inc. Methods for assessing disease risk
AU2010311535B2 (en) 2009-10-26 2015-05-21 Lifecodexx Ag Means and methods for non-invasive diagnosis of chromosomal aneuploidy
US9361426B2 (en) 2009-11-12 2016-06-07 Esoterix Genetic Laboratories, Llc Copy number analysis of genetic locus
US20110237444A1 (en) 2009-11-20 2011-09-29 Life Technologies Corporation Methods of mapping genomic methylation patterns
US9023769B2 (en) 2009-11-30 2015-05-05 Complete Genomics, Inc. cDNA library for nucleic acid sequencing
US9752187B2 (en) 2009-12-11 2017-09-05 Nucleix Categorization of DNA samples
US9315857B2 (en) 2009-12-15 2016-04-19 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse label-tags
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
DK2516680T3 (en) 2009-12-22 2016-05-02 Sequenom Inc Method and kits to identify aneuploidy
US8965076B2 (en) 2010-01-13 2015-02-24 Illumina, Inc. Data processing system and methods
US20120100548A1 (en) * 2010-10-26 2012-04-26 Verinata Health, Inc. Method for determining copy number variations
US20110177512A1 (en) 2010-01-19 2011-07-21 Predictive Biosciences, Inc. Method for assuring amplification of an abnormal nucleic acid in a sample
US9260745B2 (en) 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
US20120010085A1 (en) * 2010-01-19 2012-01-12 Rava Richard P Methods for determining fraction of fetal nucleic acids in maternal samples
AU2010343277B2 (en) 2010-01-19 2015-05-28 Verinata Health, Inc. Method for determining copy number variations
WO2012135730A2 (en) 2011-03-30 2012-10-04 Verinata Health, Inc. Method for verifying bioassay samples
WO2011091046A1 (en) 2010-01-19 2011-07-28 Verinata Health, Inc. Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing
US20130210645A1 (en) 2010-02-18 2013-08-15 The Johns Hopkins University Personalized tumor biomarkers
EP2547698B1 (en) 2010-03-14 2015-07-29 The Translational Genomics Research Institute Methods of determining susceptibility of tumors to tyrosine kinase inhibitors
CN101967517B (zh) 2010-03-19 2012-11-07 黄乐群 一种无需借助pcr的基因检测方法
PL2558854T3 (pl) 2010-04-16 2019-04-30 Chronix Biomedical Biomarkery będące krążącymi kwasami nukleinowymi związanymi z rakiem piersi
US9255291B2 (en) 2010-05-06 2016-02-09 Bioo Scientific Corporation Oligonucleotide ligation methods for improving data quality and throughput using massively parallel sequencing
US20140186827A1 (en) * 2010-05-14 2014-07-03 Fluidigm, Inc. Assays for the detection of genotype, mutations, and/or aneuploidy
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
CA2801468C (en) 2010-06-04 2018-09-04 Chronix Biomedical Prostate cancer associated circulating nucleic acid biomarkers
ES2960184T3 (es) 2010-06-09 2024-03-01 Keygene Nv Códigos de barras de secuencias combinatorias para el cribado de alto rendimiento
EP2400035A1 (en) 2010-06-28 2011-12-28 Technische Universität München Methods and compositions for diagnosing gastrointestinal stromal tumors
WO2012006291A2 (en) * 2010-07-06 2012-01-12 Life Technologies Corporation Systems and methods to detect copy number variation
MX382244B (es) 2010-07-23 2025-03-13 Harvard College Metodos para detectar firmas de enfermedad o condiciones en fluidos corporales
EP2599545B1 (en) 2010-07-29 2019-09-04 Toto Ltd. Photocatalyst coated body and photocatalyst coating liquid
CN103392182B (zh) 2010-08-02 2017-07-04 众有生物有限公司 用于发现遗传疾病中致病突变的系统和方法
US11031095B2 (en) * 2010-08-06 2021-06-08 Ariosa Diagnostics, Inc. Assay systems for determination of fetal copy number variation
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
EP2426217A1 (en) 2010-09-03 2012-03-07 Centre National de la Recherche Scientifique (CNRS) Analytical methods for cell free nucleic acids and applications
CA2811000A1 (en) 2010-09-09 2012-03-15 Traxxsson, Llc Combination methods of diagnosing cancer in a patient
EP2619327B1 (en) 2010-09-21 2014-10-22 Population Genetics Technologies LTD. Increasing confidence of allele calls with molecular counting
RU2565550C2 (ru) 2010-09-24 2015-10-20 Те Борд Оф Трастиз Оф Те Лилэнд Стэнфорд Джуниор Юниверсити Прямой захват, амплификация и секвенирование днк-мишени с использованием иммобилизированных праймеров
WO2012042374A2 (en) 2010-10-01 2012-04-05 Anssi Jussi Nikolai Taipale Method of determining number or concentration of molecules
EP2625320B1 (en) 2010-10-08 2019-03-27 President and Fellows of Harvard College High-throughput single cell barcoding
US8725422B2 (en) 2010-10-13 2014-05-13 Complete Genomics, Inc. Methods for estimating genome-wide copy number variations
WO2012054873A2 (en) 2010-10-22 2012-04-26 Cold Spring Harbor Laboratory Varietal counting of nucleic acids for obtaining genomic copy number information
WO2012066451A1 (en) 2010-11-15 2012-05-24 Pfizer Inc. Prognostic and predictive gene signature for colon cancer
SG10202008532PA (en) 2010-11-30 2020-10-29 Univ Hong Kong Chinese Detection of genetic or molecular aberrations associated with cancer
EP2656263B1 (en) 2010-12-22 2019-11-06 Natera, Inc. Methods for non-invasive prenatal paternity testing
US20120184449A1 (en) * 2010-12-23 2012-07-19 Sequenom, Inc. Fetal genetic variation detection
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
KR20140024270A (ko) 2010-12-30 2014-02-28 파운데이션 메디신 인코포레이티드 종양 샘플의 다유전자 분석의 최적화
WO2012097053A1 (en) 2011-01-11 2012-07-19 Via Genomes, Inc. Methods, systems, databases, kits and arrays for screening for and predicting the risk of and identifying the presence of tumors and cancers
US20120190020A1 (en) 2011-01-25 2012-07-26 Aria Diagnostics, Inc. Detection of genetic abnormalities
US20140024539A1 (en) * 2011-02-02 2014-01-23 Translational Genomics Research Institute Biomarkers and methods of use thereof
JP6153874B2 (ja) 2011-02-09 2017-06-28 ナテラ， インコーポレイテッド 非侵襲的出生前倍数性呼び出しのための方法
US20120238464A1 (en) 2011-03-18 2012-09-20 Baylor Research Institute Biomarkers for Predicting the Recurrence of Colorectal Cancer Metastasis
WO2012129363A2 (en) 2011-03-24 2012-09-27 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
US9411937B2 (en) 2011-04-15 2016-08-09 Verinata Health, Inc. Detecting and classifying copy number variation
AU2012242847B2 (en) 2011-04-15 2017-01-19 The Johns Hopkins University Safe sequencing system
WO2012149042A2 (en) 2011-04-25 2012-11-01 Bio-Rad Laboratories, Inc. Methods and compositions for nucleic acid analysis
US8697408B2 (en) 2011-05-06 2014-04-15 New England Biolabs, Inc. Ligation enhancement
US9074204B2 (en) 2011-05-20 2015-07-07 Fluidigm Corporation Nucleic acid encoding reactions
US9752176B2 (en) 2011-06-15 2017-09-05 Ginkgo Bioworks, Inc. Methods for preparative in vitro cloning
WO2013019075A2 (ko) 2011-08-01 2013-02-07 연세대학교산학협력단 핵산분자의 제조방법
US10704164B2 (en) 2011-08-31 2020-07-07 Life Technologies Corporation Methods, systems, computer readable media, and kits for sample identification
WO2013033721A1 (en) 2011-09-02 2013-03-07 Atreca, Inc. Dna barcodes for multiplexed sequencing
US8712697B2 (en) 2011-09-07 2014-04-29 Ariosa Diagnostics, Inc. Determination of copy number variations using binomial probability calculations
US20130079241A1 (en) 2011-09-15 2013-03-28 Jianhua Luo Methods for Diagnosing Prostate Cancer and Predicting Prostate Cancer Relapse
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140242588A1 (en) 2011-10-06 2014-08-28 Sequenom, Inc Methods and processes for non-invasive assessment of genetic variations
US20130102485A1 (en) 2011-10-19 2013-04-25 Inhan Lee Method of Determining a Diseased State in a Subject
NO3051026T3 (pl) 2011-10-21 2018-07-28
EP2768985B1 (en) 2011-10-21 2019-03-20 Chronix Biomedical Colorectal cancer associated circulating nucleic acid biomarkers
US20130122499A1 (en) 2011-11-14 2013-05-16 Viomics, Inc. System and method of detecting local copy number variation in dna samples
US10214775B2 (en) 2011-12-07 2019-02-26 Chronix Biomedical Prostate cancer associated circulating nucleic acid biomarkers
EP2788770B1 (en) 2011-12-08 2021-02-10 Five3 Genomics, LLC Mdm2-containing double minute chromosomes and methods therefore
CN108611398A (zh) 2012-01-13 2018-10-02 Data生物有限公司 通过新一代测序进行基因分型
HUE053360T2 (hu) 2012-02-17 2021-06-28 Hutchinson Fred Cancer Res Kompozíciók és eljárások mutációk pontos azonosítására
CA2865575C (en) 2012-02-27 2024-01-16 Cellular Research, Inc. Compositions and kits for molecular counting
US11177020B2 (en) 2012-02-27 2021-11-16 The University Of North Carolina At Chapel Hill Methods and uses for molecular tags
EP2820155B1 (en) 2012-02-28 2017-07-26 Population Genetics Technologies Ltd. Method for attaching a counter sequence to a nucleic acid sample
US9890429B2 (en) 2012-02-29 2018-02-13 Dana-Farber Cancer Institute, Inc. Compositions, kits, and methods for the identification, assessment, prevention, and therapy of cancer
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
EP2825675B1 (en) 2012-03-13 2017-12-27 Patel, Abhijit Ajit Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing
WO2013142213A1 (en) 2012-03-20 2013-09-26 Wake Forest University Health Sciences Methods, systems, and computer readable media for tracking and verifying receipt of contents of a delivery within an organization
ES2828661T3 (es) 2012-03-20 2021-05-27 Univ Washington Through Its Center For Commercialization Métodos para reducir la tasa de error de la secuenciación de ADN masiva en paralelo mediante el uso de la secuenciación de secuencia consenso bicatenaria
US10053729B2 (en) 2012-03-26 2018-08-21 The Johns Hopkins University Rapid aneuploidy detection
US8209130B1 (en) * 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
AU2013249012B2 (en) 2012-04-19 2019-03-28 The Medical College Of Wisconsin, Inc. Highly sensitive surveillance using detection of cell free DNA
EP2850211B1 (en) 2012-05-14 2021-09-08 iRepertoire, Inc. Method for increasing accuracy in quantitative detection of polynucleotides
CA2872141C (en) 2012-05-31 2016-01-19 Board Of Regents, The University Of Texas System Method for accurate sequencing of dna
EP2859123A4 (en) 2012-06-11 2015-12-16 Sequenta Inc METHOD OF SEQUENCE DETERMINATION USING SEQUENCE TAGS
US11261494B2 (en) 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
WO2014004726A1 (en) 2012-06-26 2014-01-03 Caifu Chen Methods, compositions and kits for the diagnosis, prognosis and monitoring of cancer
WO2014014497A1 (en) 2012-07-20 2014-01-23 Verinata Health, Inc. Detecting and classifying copy number variation in a cancer genome
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
DE202013012824U1 (de) 2012-09-04 2020-03-10 Guardant Health, Inc. Systeme zum Erfassen von seltenen Mutationen und einer Kopienzahlvariation
US20140066317A1 (en) 2012-09-04 2014-03-06 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
EP3561072A1 (en) 2012-12-10 2019-10-30 Resolution Bioscience, Inc. Methods for targeted genomic analysis
CA2897190C (en) 2013-01-05 2023-06-13 Foundation Medicine, Inc. System and method for outcome tracking and analysis
WO2014113729A2 (en) 2013-01-18 2014-07-24 Foundation Mecicine, Inc. Methods of treating cholangiocarcinoma
US20160034638A1 (en) 2013-03-14 2016-02-04 University Of Rochester System and Method for Detecting Population Variation from Nucleic Acid Sequencing Data
CN114574581A (zh) * 2013-03-15 2022-06-03 夸登特健康公司 检测稀有突变和拷贝数变异的系统和方法
WO2014144495A1 (en) * 2013-03-15 2014-09-18 Abvitro, Inc. Single cell bar-coding for antibody discovery
CN105358709B (zh) 2013-03-15 2018-12-07 雅培分子公司 用于检测基因组拷贝数变化的系统和方法
US10017807B2 (en) 2013-03-15 2018-07-10 Verinata Health, Inc. Generating cell-free DNA libraries directly from blood
CN113337604A (zh) 2013-03-15 2021-09-03 莱兰斯坦福初级大学评议会 循环核酸肿瘤标志物的鉴别和用途
WO2014148557A1 (ja) 2013-03-19 2014-09-25 凸版印刷株式会社 Ｅｇｆｒ阻害剤感受性予測方法
EP4617376A3 (en) 2013-05-23 2025-12-10 The Board of Trustees of the Leland Stanford Junior University Transposition into native chromatin for personal epigenomics
CA2929596C (en) 2013-11-13 2022-07-05 Nugen Technologies, Inc. Compositions and methods for identification of a duplicate sequencing read
JP2015096049A (ja) 2013-11-15 2015-05-21 凸版印刷株式会社 Ｖｅｇｆ阻害剤長期奏功性予測方法
ES2660989T3 (es) 2013-12-28 2018-03-27 Guardant Health, Inc. Métodos y sistemas para detectar variantes genéticas
WO2015159293A2 (en) 2014-04-14 2015-10-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. A method and kit for determining the tissue or cell origin of dna
CN113774132A (zh) 2014-04-21 2021-12-10 纳特拉公司 检测染色体片段中的突变和倍性
ES2844229T3 (es) 2014-05-13 2021-07-21 Univ Texas Mutaciones génicas y alteraciones en el número de copias de EGFR, KRAS y MET
CA2956208C (en) 2014-07-25 2025-07-08 University Of Washington METHODS FOR DETERMINING TISSUES AND/OR CELL TYPES RENDERING CELL-FREE DNA AND RELATED METHODS FOR DETERMINING A DISEASE OR DISORDER
RS62803B1 (sr) 2014-07-25 2022-02-28 Bgi Genomics Co Limited Postupak za određivanje frakcije slobodnih fetalnih nukleinskih kiselina u uzorku periferne krvi trudnice i njihova upotreba
US20160053301A1 (en) 2014-08-22 2016-02-25 Clearfork Bioscience, Inc. Methods for quantitative genetic analysis of cell free dna
WO2016039950A1 (en) 2014-09-10 2016-03-17 Pathway Genomics Corporation Health and wellness management methods and systems useful for the practice thereof
ES2925014T3 (es) 2014-09-12 2022-10-13 Univ Leland Stanford Junior Identificación y uso de ácidos nucleicos circulantes
SG11201706529TA (en) 2015-02-10 2017-09-28 Univ Hong Kong Chinese Detecting mutations for cancer screening and fetal analysis
US10844428B2 (en) 2015-04-28 2020-11-24 Illumina, Inc. Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS)
PL3387152T3 (pl) 2015-12-08 2022-05-09 Twinstrand Biosciences, Inc. Ulepszone adaptory, sposoby i kompozycje do sekwencjonowania dupleksowego
EP3433373B1 (en) 2016-03-22 2022-01-12 Myriad Women's Health, Inc. Combinatorial dna screening
WO2017181146A1 (en) 2016-04-14 2017-10-19 Guardant Health, Inc. Methods for early detection of cancer

Also Published As

Publication number Publication date
HK1225416B (zh) 2017-09-08
US10041127B2 (en) 2018-08-07
US20220042104A1 (en) 2022-02-10
US20240240258A1 (en) 2024-07-18
CN104781421A (zh) 2015-07-15
WO2014039556A1 (en) 2014-03-13
IL269097B1 (en) 2023-09-01
JP6664025B2 (ja) 2020-03-13
US11001899B1 (en) 2021-05-11
US9840743B2 (en) 2017-12-12
US10995376B1 (en) 2021-05-04
US20240200150A1 (en) 2024-06-20
EP2893040B1 (en) 2019-01-02
KR20210013317A (ko) 2021-02-03
KR102393608B1 (ko) 2022-05-03
GB2533006A (en) 2016-06-08
US10961592B2 (en) 2021-03-30
US10793916B2 (en) 2020-10-06
US20220205051A1 (en) 2022-06-30
DK2893040T5 (en) 2019-03-18
ES2769241T3 (es) 2020-06-25
US10738364B2 (en) 2020-08-11
PT2893040T (pt) 2019-04-01
US20190177802A1 (en) 2019-06-13
EP2893040A4 (en) 2016-04-27
US10876171B2 (en) 2020-12-29
KR102210852B1 (ko) 2021-02-01
US10457995B2 (en) 2019-10-29
US20230323477A1 (en) 2023-10-12
CN110872617A (zh) 2020-03-10
US20150299812A1 (en) 2015-10-22
US20210340632A1 (en) 2021-11-04
EP3842551A1 (en) 2021-06-30
GB201509071D0 (en) 2015-07-08
US20170218460A1 (en) 2017-08-03
US20250223656A1 (en) 2025-07-10
US9834822B2 (en) 2017-12-05
KR20190112843A (ko) 2019-10-07
US20180223374A1 (en) 2018-08-09
US12049673B2 (en) 2024-07-30
US20180171415A1 (en) 2018-06-21
US20250376734A1 (en) 2025-12-11
MX2015002769A (es) 2015-08-14
US10947600B2 (en) 2021-03-16
US20190185940A1 (en) 2019-06-20
ES2968333T3 (es) 2024-05-09
JP6275145B2 (ja) 2018-02-07
JP2018027096A (ja) 2018-02-22
US10876172B2 (en) 2020-12-29
JP2022169566A (ja) 2022-11-09
KR102028375B1 (ko) 2019-10-04
US20250051858A1 (en) 2025-02-13
JP7119014B2 (ja) 2022-08-16
MX367963B (es) 2019-09-11
CA2883901C (en) 2023-04-11
US20190177803A1 (en) 2019-06-13
US12606874B2 (en) 2026-04-21
US20200291487A1 (en) 2020-09-17
US12054783B2 (en) 2024-08-06
US20210032707A1 (en) 2021-02-04
BR112015004847A2 (pt) 2020-04-22
US12252749B2 (en) 2025-03-18
US10501810B2 (en) 2019-12-10
PL3591073T3 (pl) 2022-03-28
US20150368708A1 (en) 2015-12-24
US20180327862A1 (en) 2018-11-15
SG11201501662TA (en) 2015-05-28
EP4036247A1 (en) 2022-08-03
US10494678B2 (en) 2019-12-03
US20200248270A1 (en) 2020-08-06
DE202013012824U1 (de) 2020-03-10
JP2025016591A (ja) 2025-02-04
ES2711635T3 (es) 2019-05-06
GB2533006B (en) 2017-06-07
IL305303A (en) 2023-10-01
IL237480B (en) 2019-10-31
CA2883901A1 (en) 2014-03-13
US9598731B2 (en) 2017-03-21
US20230151435A1 (en) 2023-05-18
US20170218459A1 (en) 2017-08-03
IL237480A0 (en) 2015-04-30
JP2015535681A (ja) 2015-12-17
ES2984550T3 (es) 2024-10-29
DK2893040T3 (en) 2019-03-11
IL269097B2 (en) 2024-01-01
EP3591073B1 (en) 2021-12-01
HK1212396A1 (en) 2016-06-10
US20210139998A1 (en) 2021-05-13
US10501808B2 (en) 2019-12-10
EP4424826A2 (en) 2024-09-04
US20200087736A1 (en) 2020-03-19
EP3470533B1 (en) 2019-11-06
US20200299785A1 (en) 2020-09-24
KR20240007774A (ko) 2024-01-16
US11319597B2 (en) 2022-05-03
US20210355549A1 (en) 2021-11-18
HK1201080A1 (zh) 2015-08-21
CN104781421B (zh) 2020-06-05
SG10202000486VA (en) 2020-03-30
US20190185941A1 (en) 2019-06-20
US11319598B2 (en) 2022-05-03
EP4036247B1 (en) 2024-04-10
KR20150067161A (ko) 2015-06-17
EP3470533B2 (en) 2023-01-18
US11773453B2 (en) 2023-10-03
EP3591073A1 (en) 2020-01-08
ES2906714T3 (es) 2022-04-20
US10683556B2 (en) 2020-06-16
US20210130912A1 (en) 2021-05-06
ES2769241T5 (es) 2023-05-30
KR20260025883A (ko) 2026-02-24
US10837063B2 (en) 2020-11-17
KR20220061271A (ko) 2022-05-12
US20260043090A1 (en) 2026-02-12
EP3842551C0 (en) 2023-11-01
EP4424826A3 (en) 2024-11-27
EP3470533A1 (en) 2019-04-17
US11879158B2 (en) 2024-01-23
JP2020103298A (ja) 2020-07-09
IL269097A (en) 2019-11-28
CA3190199A1 (en) 2014-03-13
US12624400B2 (en) 2026-05-12
EP3842551B1 (en) 2023-11-01
US10822663B2 (en) 2020-11-03
US20200087735A1 (en) 2020-03-19
EP2893040A1 (en) 2015-07-15
US12319972B2 (en) 2025-06-03
US12110560B2 (en) 2024-10-08
JP2020000237A (ja) 2020-01-09

Similar Documents

Publication Publication Date Title
IL269097B1 (en) Systems and methods for detecting rare mutations and changes in number of copies
GB2528205B (en) Systems and methods to detect rare mutations and copy number variation
GB2523013B (en) Method and system to detect and select best photographs
GB2493514B (en) Copy detection
GB201322442D0 (en) Object detection methods display methods and apparatuses
GB2500915B (en) Arrangement and method
IL235826A0 (en) Diazaspirocycloalkane and azaspirocycloalkane
ZA201503461B (en) Apparatus and methods employing liquid-impregnated surfaces
EP2836923A4 (en) METHODS AND APPARATUS FOR COPYING AND INSERTING INFORMATION
IL239369A0 (en) Pyrocyclic morphines and their use
HUE036039T2 (hu) Neutrondetektor egység, valamint neutrondetektor elrendezés
AP2014008113A0 (en) Pipeline and methods
GB201218084D0 (en) Novel compounds and methods for use in medicine
GB2510479B (en) Touch system and method
GB201213778D0 (en) Process and dressng
GB201221092D0 (en) Assemblies and methods
GB2510725B (en) Systems and methods to detect rare mutations and copy number variation
GB2506548B (en) Improvements to security arrangement methods and computer software
GB201211961D0 (en) Methods and groups
GB201208845D0 (en) Methods and groups
GB201209873D0 (en) Equipment-transport apparatus and methods
GB201218122D0 (en) Detection methods
GB201218654D0 (en) Methods and product
GB201219274D0 (en) Pyrolysis methods and apparatus
GB201222541D0 (en) Kiddibidet and pottibidet