MX367963B - Métodos para detectar mutaciones raras y variación en el número de copias. - Google Patents

Métodos para detectar mutaciones raras y variación en el número de copias.

Info

Publication number
MX367963B
MX367963B MX2015002769A MX2015002769A MX367963B MX 367963 B MX367963 B MX 367963B MX 2015002769 A MX2015002769 A MX 2015002769A MX 2015002769 A MX2015002769 A MX 2015002769A MX 367963 B MX367963 B MX 367963B
Authority
MX
Mexico
Prior art keywords
copy number
rare mutations
systems
methods
number variation
Prior art date
Application number
MX2015002769A
Other languages
English (en)
Other versions
MX2015002769A (es
Inventor
Amirali Talasaz
Helmy Eltoukhy
Original Assignee
Guardant Health Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50237580&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX367963(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Guardant Health Inc filed Critical Guardant Health Inc
Publication of MX2015002769A publication Critical patent/MX2015002769A/es
Publication of MX367963B publication Critical patent/MX367963B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/165—Mathematical modelling, e.g. logarithm, ratio
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2545/00—Reactions characterised by their quantitative nature
    • C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
    • C12Q2545/114—Reactions characterised by their quantitative nature the purpose being quantitative analysis involving a quantitation step
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Abstract

La presente invención se refiere a proporciona un sistema y método para la detección de mutaciones raras y variaciones en el número de copias en polinucleótidos libres de células. En general, los sistemas y métodos comprenden la preparación de la muestra, o la extracción y aislamiento de secuencias de polinucleótidos libres de células a partir de un fluido corporal; la subsecuente secuenciación de polinucleótidos libres de células por técnicas conocidas en la técnica; y la aplicación de herramientas bioinformáticas para detectar mutaciones raras y variaciones en el número de copias en comparación con una referencia. Los sistemas y métodos pueden contener una base de datos o colección de diferentes mutaciones o perfiles de variación en el número de copias de diferentes enfermedades, que se van a usar como referencias adicionales al ayudar en la detección de mutaciones raras, perfil de la variación en el número de copias o perfil genético general de una enfermedad.
MX2015002769A 2012-09-04 2013-09-04 Métodos para detectar mutaciones raras y variación en el número de copias. MX367963B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261696734P 2012-09-04 2012-09-04
US201261704400P 2012-09-21 2012-09-21
US201361793997P 2013-03-15 2013-03-15
US201361845987P 2013-07-13 2013-07-13
PCT/US2013/058061 WO2014039556A1 (en) 2012-09-04 2013-09-04 Systems and methods to detect rare mutations and copy number variation

Publications (2)

Publication Number Publication Date
MX2015002769A MX2015002769A (es) 2015-08-14
MX367963B true MX367963B (es) 2019-09-11

Family

ID=50237580

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015002769A MX367963B (es) 2012-09-04 2013-09-04 Métodos para detectar mutaciones raras y variación en el número de copias.

Country Status (18)

Country Link
US (25) US10041127B2 (es)
EP (5) EP3591073B1 (es)
JP (5) JP6275145B2 (es)
KR (5) KR20240007774A (es)
CN (2) CN110872617A (es)
BR (1) BR112015004847A2 (es)
CA (2) CA3190199A1 (es)
DE (1) DE202013012824U1 (es)
DK (1) DK2893040T5 (es)
ES (3) ES2711635T3 (es)
GB (1) GB2533006B (es)
HK (3) HK1201080A1 (es)
IL (3) IL305303A (es)
MX (1) MX367963B (es)
PL (2) PL3591073T3 (es)
PT (1) PT2893040T (es)
SG (2) SG11201501662TA (es)
WO (1) WO2014039556A1 (es)

Families Citing this family (264)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US10083273B2 (en) 2005-07-29 2018-09-25 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111544B2 (en) * 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
US10017812B2 (en) 2010-05-18 2018-07-10 Natera, Inc. Methods for non-invasive prenatal ploidy calling
EP2473638B1 (en) 2009-09-30 2017-08-09 Natera, Inc. Methods for non-invasive prenatal ploidy calling
EP2572003A4 (en) 2010-05-18 2016-01-13 Natera Inc METHOD FOR NONINVASIVE PRANATAL PLOIDIE ASSIGNMENT
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
CN103608466B (zh) 2010-12-22 2020-09-18 纳特拉公司 非侵入性产前亲子鉴定方法
EP3225697A3 (en) 2010-12-30 2017-11-22 Foundation Medicine, Inc. Optimization of multigene analysis of tumor samples
WO2012129363A2 (en) 2011-03-24 2012-09-27 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
CN103748236B (zh) 2011-04-15 2018-12-25 约翰·霍普金斯大学 安全测序系统
WO2012177792A2 (en) 2011-06-24 2012-12-27 Sequenom, Inc. Methods and processes for non-invasive assessment of a genetic variation
US20130079241A1 (en) 2011-09-15 2013-03-28 Jianhua Luo Methods for Diagnosing Prostate Cancer and Predicting Prostate Cancer Relapse
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140242588A1 (en) 2011-10-06 2014-08-28 Sequenom, Inc Methods and processes for non-invasive assessment of genetic variations
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
WO2013109981A1 (en) 2012-01-20 2013-07-25 Sequenom, Inc. Diagnostic processes that factor experimental conditions
ES2665071T3 (es) 2012-02-17 2018-04-24 Fred Hutchinson Cancer Research Center Composiciones y métodos para identificar mutaciones de manera precisa
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
PT2828218T (pt) 2012-03-20 2020-11-11 Univ Washington Through Its Center For Commercialization Métodos para baixar a taxa de erro da sequenciação paralela massiva de adn utilizando sequenciação duplex de consensus
EP2844771A4 (en) * 2012-05-04 2015-12-02 Complete Genomics Inc METHOD FOR DETERMINING THE ABSOLUTE GENOME-WIDE COPY COUNTER CHANGES OF COMPLEX TUMORS
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US11261494B2 (en) 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
KR20240007774A (ko) 2012-09-04 2024-01-16 가던트 헬쓰, 인크. 희귀 돌연변이 및 카피수 변이를 검출하기 위한 시스템 및 방법
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
AU2013338393B2 (en) 2012-10-29 2017-05-11 The Johns Hopkins University Papanicolaou test for ovarian and endometrial cancers
US9218450B2 (en) * 2012-11-29 2015-12-22 Roche Molecular Systems, Inc. Accurate and fast mapping of reads to genome
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CN105408496A (zh) 2013-03-15 2016-03-16 夸登特健康公司 检测稀有突变和拷贝数变异的系统和方法
WO2014144092A1 (en) 2013-03-15 2014-09-18 Nugen Technologies, Inc. Sequential sequencing
US10930368B2 (en) 2013-04-03 2021-02-23 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CA2910205C (en) 2013-05-24 2023-04-04 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
TR201904345T4 (tr) 2013-06-21 2019-04-22 Sequenom Inc Genetik Varyasyonları Non-İnvazif Değerlendirme Yöntemi
US10577655B2 (en) 2013-09-27 2020-03-03 Natera, Inc. Cell free DNA diagnostic testing standards
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
CA3205430A1 (en) 2013-10-04 2015-04-09 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP3851539A1 (en) 2013-10-07 2021-07-21 Sequenom, Inc. Methods and processes for non-invasive assessment of chromosome alterations
CA2928185C (en) 2013-10-21 2024-01-30 Verinata Health, Inc. Method for improving the sensitivity of detection in determining copy number variations
EP3066236B1 (en) 2013-11-07 2022-08-24 The Board of Trustees of the Leland Stanford Junior University Cell-free nucleic acids for the analysis of the human microbiome and components thereof
CA2929596C (en) 2013-11-13 2022-07-05 Nugen Technologies, Inc. Compositions and methods for identification of a duplicate sequencing read
CN111534580A (zh) 2013-12-28 2020-08-14 夸登特健康公司 用于检测遗传变异的方法和系统
ES2818625T3 (es) 2013-12-30 2021-04-13 Univ Pittsburgh Commonwealth Sys Higher Education Genes de fusión asociados con el cáncer de próstata progresivo
CN106460070B (zh) 2014-04-21 2021-10-08 纳特拉公司 检测染色体片段中的突变和倍性
EP3143163B1 (en) 2014-05-13 2020-11-25 Board of Regents, The University of Texas System Gene mutations and copy number alterations of egfr, kras and met
EP3149202A1 (en) * 2014-05-26 2017-04-05 Ebios Futura S.r.l. Method of prenatal diagnosis
BR112016027848A2 (pt) 2014-05-30 2017-08-22 Verinata Health Inc Método para avaliação de número de cópias de uma sequência de interesse, meio legível por máquina não transitória, e, sistema para avaliação de número de cópias de uma sequência de interesse
CA3191504A1 (en) * 2014-05-30 2015-12-03 Sequenom, Inc. Chromosome representation determinations
WO2016011428A1 (en) 2014-07-17 2016-01-21 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods of treating cells containing fusion genes
TWI703216B (zh) 2014-07-18 2020-09-01 香港中文大學 Ｄｎａ混合物中之組織甲基化模式分析
GB201412834D0 (en) * 2014-07-18 2014-09-03 Cancer Rec Tech Ltd A method for detecting a genetic variant
KR20220127359A (ko) 2014-07-25 2022-09-19 유니버시티 오브 워싱톤 무세포 dna를 생성하는 조직 및/또는 세포 유형을 결정하는 방법 및 이를 사용하여 질환 또는 장애를 확인하는 방법
US20160034640A1 (en) 2014-07-30 2016-02-04 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10102337B2 (en) 2014-08-06 2018-10-16 Nugen Technologies, Inc. Digital measurements from targeted sequencing
CN107075564A (zh) * 2014-12-10 2017-08-18 深圳华大基因研究院 确定肿瘤核酸浓度的方法和装置
US11072814B2 (en) * 2014-12-12 2021-07-27 Verinata Health, Inc. Using cell-free DNA fragment size to determine copy number variations
WO2016095093A1 (zh) * 2014-12-15 2016-06-23 天津华大基因科技有限公司 肿瘤筛查方法、目标区域变异检测方法和装置
US9859394B2 (en) 2014-12-18 2018-01-02 Agilome, Inc. Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids
US9857328B2 (en) 2014-12-18 2018-01-02 Agilome, Inc. Chemically-sensitive field effect transistors, systems and methods for manufacturing and using the same
US10429342B2 (en) 2014-12-18 2019-10-01 Edico Genome Corporation Chemically-sensitive field effect transistor
US10020300B2 (en) 2014-12-18 2018-07-10 Agilome, Inc. Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids
US10006910B2 (en) 2014-12-18 2018-06-26 Agilome, Inc. Chemically-sensitive field effect transistors, systems, and methods for manufacturing and using the same
US9618474B2 (en) 2014-12-18 2017-04-11 Edico Genome, Inc. Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids
US20160188793A1 (en) * 2014-12-29 2016-06-30 Counsyl, Inc. Method For Determining Genotypes in Regions of High Homology
EP3240911B1 (en) * 2014-12-31 2020-08-26 Guardant Health, Inc. Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results
US10364467B2 (en) * 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
AU2016218631B2 (en) * 2015-02-10 2022-03-10 The Chinese University Of Hong Kong Detecting mutations for cancer screening and fetal analysis
CN107708556B (zh) 2015-05-01 2022-01-04 夸登特健康公司 诊断方法
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
JP6873921B2 (ja) 2015-05-18 2021-05-19 カリウス・インコーポレイテッド 核酸の集団を濃縮するための組成物および方法
US10395759B2 (en) * 2015-05-18 2019-08-27 Regeneron Pharmaceuticals, Inc. Methods and systems for copy number variant detection
US10344336B2 (en) 2015-06-09 2019-07-09 Life Technologies Corporation Methods, systems, compositions, kits, apparatus and computer-readable media for molecular tagging
SG11201707649SA (en) * 2015-06-24 2017-10-30 Samsung Life Public Welfare Foundation Method and device for analyzing gene
GB201819855D0 (en) * 2015-07-07 2019-01-23 Farsight Genome Systems Inc Methods and systems for sequencing-based variant detection
US20180211002A1 (en) * 2015-07-13 2018-07-26 Agilent Technologies Belgium Nv System and methodology for the analysis of genomic data obtained from a subject
EP3828292A1 (en) * 2015-07-21 2021-06-02 Guardant Health, Inc. Locked nucleic acids for capturing fusion genes
TW202332776A (zh) 2015-07-23 2023-08-16 香港中文大學 游離dna(cell-free dna)之片段化模式分析
CA2993619A1 (en) * 2015-07-29 2017-02-02 Progenity, Inc. Systems and methods for genetic analysis
EP3329010B1 (en) 2015-07-29 2019-07-10 Progenity, Inc. Nucleic acids and methods for detecting chromosomal abnormalities
CA2994848C (en) * 2015-08-07 2021-08-10 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Methods for predicting prostate cancer relapse
US11286531B2 (en) 2015-08-11 2022-03-29 The Johns Hopkins University Assaying ovarian cyst fluid
US11302416B2 (en) 2015-09-02 2022-04-12 Guardant Health Machine learning for somatic single nucleotide variant detection in cell-free tumor nucleic acid sequencing applications
AU2016321204B2 (en) * 2015-09-08 2022-12-01 Cold Spring Harbor Laboratory Genetic copy number determination using high throughput multiplex sequencing of smashed nucleotides
EP3359694A4 (en) 2015-10-09 2019-07-17 Guardant Health, Inc. POPULATION-BASED TREATMENT TREATMENT USING CELL-FREE DNA
KR101848438B1 (ko) 2015-10-29 2018-04-13 바이오코아 주식회사 디지털 pcr을 이용한 산전진단 방법
AU2016343937B2 (en) 2015-10-30 2023-01-19 Exact Sciences Corporation Multiplex amplification detection assay and isolation and detection of DNA from plasma
JP6913089B2 (ja) 2015-11-11 2021-08-04 レゾリューション バイオサイエンス， インコーポレイテッド Ｄｎａライブラリーの高効率構築
US20180330050A1 (en) * 2015-11-16 2018-11-15 Mayo Foundation For Medical Education And Research Detecting copy number variations
CN109072294A (zh) 2015-12-08 2018-12-21 特温斯特兰德生物科学有限公司 用于双重测序的改良衔接子、方法和组合物
CA3008651A1 (en) 2015-12-17 2017-06-22 Guardant Health, Inc. Methods to determine tumor gene copy number by analysis of cell-free dna
WO2017127741A1 (en) * 2016-01-22 2017-07-27 Grail, Inc. Methods and systems for high fidelity sequencing
CN116640847A (zh) 2016-02-02 2023-08-25 夸登特健康公司 癌症进化检测和诊断
US10095831B2 (en) 2016-02-03 2018-10-09 Verinata Health, Inc. Using cell-free DNA fragment size to determine copy number variations
US11479878B2 (en) 2016-03-16 2022-10-25 Dana-Farber Cancer Institute, Inc. Methods for genome characterization
US9976181B2 (en) 2016-03-25 2018-05-22 Karius, Inc. Synthetic nucleic acid spike-ins
US11384382B2 (en) 2016-04-14 2022-07-12 Guardant Health, Inc. Methods of attaching adapters to sample nucleic acids
US20190085406A1 (en) 2016-04-14 2019-03-21 Guardant Health, Inc. Methods for early detection of cancer
ITUA20162640A1 (it) * 2016-04-15 2017-10-15 Menarini Silicon Biosystems Spa Metodo e kit per la generazione di librerie di dna per sequenziamento massivo parallelo
EP3459115A4 (en) 2016-05-16 2020-04-08 Agilome, Inc. GRAPHEN-FET DEVICES, SYSTEMS AND METHODS FOR USE THEREOF FOR SEQUENCING NUCLEIC ACIDS
WO2017201102A1 (en) 2016-05-16 2017-11-23 Accuragen Holdings Limited Method of improved sequencing by strand identification
JP2019521673A (ja) * 2016-06-07 2019-08-08 ザ リージェンツ オブ ザ ユニヴァーシティー オブ カリフォルニア 疾患および状態の分析のためのセルフリーｄｎａメチル化パターン
US10144962B2 (en) 2016-06-30 2018-12-04 Grail, Inc. Differential tagging of RNA for preparation of a cell-free DNA/RNA sequencing library
CN107577917A (zh) * 2016-07-05 2018-01-12 魏霖静 一种生物信息学高性能信息化管理系统及数据处理方法
BR112019000296A2 (pt) 2016-07-06 2019-04-16 Guardant Health, Inc. métodos para a determinação de perfil de fragmentome de ácidos nucleicos livres de célula
JP7048105B2 (ja) 2016-07-15 2022-04-05 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 核酸ライブラリを生成する方法
CA3030890A1 (en) 2016-07-27 2018-02-01 Sequenom, Inc. Genetic copy number alteration classifications
BR112019003704A2 (pt) 2016-08-25 2019-05-28 Resolution Bioscience Inc métodos para a detecção de alterações na cópia genômica em amostras de dna
KR102416441B1 (ko) * 2016-09-22 2022-07-04 일루미나, 인코포레이티드 체세포 복제수 변이 검출
JP6560465B1 (ja) 2016-09-30 2019-08-21 ガーダント ヘルス， インコーポレイテッド 無細胞核酸の多重解像度分析のための方法
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
US11485996B2 (en) 2016-10-04 2022-11-01 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
WO2018071595A1 (en) 2016-10-12 2018-04-19 Bellwether Bio, Inc. Determining cell type origin of circulating cell-free dna with molecular counting
CA3041647A1 (en) 2016-10-24 2018-05-03 The Chinese University Of Hong Kong Methods and systems for tumor detection
WO2018081465A1 (en) * 2016-10-26 2018-05-03 Pathway Genomics Corporation Systems and methods for characterizing nucleic acid in a biological sample
CN106566877A (zh) * 2016-10-31 2017-04-19 天津诺禾致源生物信息科技有限公司 检测基因突变的方法和装置
CA3039685A1 (en) 2016-11-30 2018-06-07 The Chinese University Of Hong Kong Analysis of cell-free dna in urine and other samples
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
WO2018106884A1 (en) * 2016-12-08 2018-06-14 Life Technologies Corporation Methods for detecting mutation load from a tumor sample
US20180166170A1 (en) * 2016-12-12 2018-06-14 Konstantinos Theofilatos Generalized computational framework and system for integrative prediction of biomarkers
IL302912A (en) 2016-12-22 2023-07-01 Guardant Health Inc Methods and systems for analyzing nucleic acid molecules
CN106701956A (zh) * 2017-01-11 2017-05-24 上海思路迪生物医学科技有限公司 ctDNA的数字化深度测序技术
US11929145B2 (en) 2017-01-20 2024-03-12 Sequenom, Inc Methods for non-invasive assessment of genetic alterations
WO2018140521A1 (en) 2017-01-24 2018-08-02 Sequenom, Inc. Methods and processes for assessment of genetic variations
SG11201906397UA (en) * 2017-01-25 2019-08-27 Univ Hong Kong Chinese Diagnostic applications using nucleic acid fragments
WO2018156418A1 (en) 2017-02-21 2018-08-30 Natera, Inc. Compositions, methods, and kits for isolating nucleic acids
CN106755547A (zh) * 2017-03-15 2017-05-31 上海亿康医学检验所有限公司 一种膀胱癌的无创检测及其复发监测方法
WO2018183942A1 (en) 2017-03-31 2018-10-04 Grail, Inc. Improved library preparation and use thereof for sequencing-based error correction and/or variant identification
EP3610034B1 (en) 2017-04-12 2022-06-08 Karius, Inc. Sample preparation methods, systems and compositions
US11342047B2 (en) 2017-04-21 2022-05-24 Illumina, Inc. Using cell-free DNA fragment size to detect tumor-associated variant
US11535896B2 (en) * 2017-05-15 2022-12-27 Katholieke Universiteit Leuven Method for analysing cell-free nucleic acids
WO2018213235A1 (en) * 2017-05-16 2018-11-22 Life Technologies Corporation Methods for compression of molecular tagged nucleic acid sequence data
EP3625341A4 (en) * 2017-05-16 2021-05-19 Guardant Health, Inc. IDENTIFICATION OF SOMATIC ORIGIN OR GERMINAL LINE OF CELLLESS DNA
KR102145417B1 (ko) * 2017-05-24 2020-08-19 지니너스 주식회사 무세포 핵산으로부터 수득된 서열 분석 데이터에 대한 배경 대립인자의 빈도 분포를 생성하는 방법 및 이를 이용하여 무세포 핵산으로부터 변이를 검출하는 방법
WO2018227202A1 (en) * 2017-06-09 2018-12-13 Bellwether Bio, Inc. Determination of cancer type in a subject by probabilistic modeling of circulating nucleic acid fragment endpoints
JP7009518B2 (ja) * 2017-06-20 2022-01-25 イルミナ インコーポレイテッド 既知又は未知の遺伝子型の複数のコントリビューターからのｄｎａ混合物の分解及び定量化のための方法並びにシステム
EP3431611A1 (en) * 2017-07-21 2019-01-23 Menarini Silicon Biosystems S.p.A. Improved method and kit for the generation of dna libraries for massively parallel sequencing
DK3658684T3 (da) * 2017-07-26 2023-10-09 Univ Hong Kong Chinese Forbedring af cancerscreening ved hjælp af cellefrie, virale nukleinsyrer
WO2019028462A1 (en) 2017-08-04 2019-02-07 Billiontoone, Inc. TARGET-ASSOCIATED MOLECULES FOR CHARACTERIZATION ASSOCIATED WITH BIOLOGICAL TARGETS
WO2019028470A2 (en) 2017-08-04 2019-02-07 Billiontoone, Inc. DETERMINING AND ANALYZING SEQUENCING OUTPUTS USING TARGET-ASSOCIATED MOLECULES IN QUANTIFICATION ASSOCIATED WITH BIOLOGICAL TARGETS
US11519024B2 (en) 2017-08-04 2022-12-06 Billiontoone, Inc. Homologous genomic regions for characterization associated with biological targets
EP3685386A1 (en) 2017-09-20 2020-07-29 Guardant Health, Inc. Methods and systems for differentiating somatic and germline variants
CN107688726B (zh) * 2017-09-21 2021-09-07 深圳市易基因科技有限公司 基于液相捕获技术判定单基因病相关拷贝数缺失的方法
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
JP7304852B2 (ja) 2017-11-03 2023-07-07 ガーダント ヘルス， インコーポレイテッド 脱アミノ化に誘導される配列エラーの補正
EP3704268A4 (en) 2017-11-03 2021-08-11 Guardant Health, Inc. NORMALIZATION OF A TUMOR MUTATION LOAD
SG11202003885UA (en) 2017-11-08 2020-05-28 Twinstrand Biosciences Inc Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters
JP7054133B2 (ja) 2017-11-09 2022-04-13 国立研究開発法人国立がん研究センター 配列解析方法、配列解析装置、参照配列の生成方法、参照配列生成装置、プログラム、および記録媒体
AU2018375302A1 (en) * 2017-11-28 2020-06-11 Grail, Llc Models for targeted sequencing
AU2018375008A1 (en) * 2017-12-01 2019-12-05 Illumina, Inc. Methods and systems for determining somatic mutation clonality
CN108197428B (zh) * 2017-12-25 2020-06-19 西安交通大学 一种并行动态规划的下一代测序技术拷贝数变异检测方法
CN109979529B (zh) * 2017-12-28 2021-01-08 北京安诺优达医学检验实验室有限公司 Cnv检测装置
US11629381B2 (en) 2018-01-05 2023-04-18 Billiontoone, Inc. Quality control templates ensuring validity of sequencing-based assays
WO2019140201A1 (en) 2018-01-12 2019-07-18 Claret Bioscience, Llc Methods and compositions for analyzing nucleic acid
IL283427B2 (en) * 2018-01-15 2023-10-01 Illumina Inc Identifying variants using Empiric ranking of variants
CN108268752B (zh) * 2018-01-18 2019-02-01 东莞博奥木华基因科技有限公司 一种染色体异常检测装置
KR102036609B1 (ko) * 2018-02-12 2019-10-28 바이오코아 주식회사 디지털 pcr을 이용한 산전진단 방법
CA3097146A1 (en) * 2018-04-16 2019-10-24 Memorial Sloan Kettering Cancer Center Systems and methods for detecting cancer via cfdna screening
WO2019204588A1 (en) 2018-04-20 2019-10-24 Biofire Diagnostics, Llc Methods for normalization and quantification of sequencing data
US20210115520A1 (en) * 2018-04-24 2021-04-22 Grail, Inc. Systems and methods for using pathogen nucleic acid load to determine whether a subject has a cancer condition
CN112888459B (zh) 2018-06-01 2023-05-23 格里尔公司 卷积神经网络系统及数据分类方法
WO2019236478A1 (en) 2018-06-04 2019-12-12 Guardant Health, Inc. Methods and systems for determining the cellular origin of cell-free nucleic acids
KR20210016560A (ko) 2018-06-06 2021-02-16 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 핵산 라이브러리의 생성 방법 및 이를 실행하기 위한 조성물 및 키트
CN109192246B (zh) * 2018-06-22 2020-10-16 深圳市达仁基因科技有限公司 检测染色体拷贝数异常的方法、装置和存储介质
US11525159B2 (en) 2018-07-03 2022-12-13 Natera, Inc. Methods for detection of donor-derived cell-free DNA
BR112019027637A2 (pt) * 2018-07-11 2020-07-07 Illumina, Inc. sistema para identificar padrões de repetição que causam erros específicos de sequência, método implementado por computador e meio de armazenamento legível por computador não transitório
AU2019300172A1 (en) 2018-07-12 2021-01-28 Twinstrand Biosciences, Inc. Methods and reagents for characterizing genomic editing, clonal expansion, and associated applications
CN112752854A (zh) 2018-07-23 2021-05-04 夸登特健康公司 用于通过肿瘤分数和覆盖率调整肿瘤突变负荷的方法和系统
WO2020021119A1 (en) * 2018-07-27 2020-01-30 F. Hoffmann-La Roche Ag Method of monitoring effectiveness of immunotherapy of cancer patients
EP3841583A4 (en) * 2018-08-22 2022-05-18 The Regents of the University of California SENSITIVE DETECTION OF COPY NUMBER VARIATIONS (CNVS) FROM CIRCULATION-FREE NUCLEIC ACID
JP2021536232A (ja) 2018-08-30 2021-12-27 ガーダント ヘルス， インコーポレイテッド 試料間の汚染を検出するための方法およびシステム
WO2020047553A1 (en) 2018-08-31 2020-03-05 Guardant Health, Inc. Genetic variant detection based on merged and unmerged reads
EP3844761A1 (en) 2018-08-31 2021-07-07 Guardant Health, Inc. Microsatellite instability detection in cell-free dna
EP3847276A2 (en) 2018-09-04 2021-07-14 Guardant Health, Inc. Methods and systems for detecting allelic imbalance in cell-free nucleic acid samples
WO2020056302A1 (en) * 2018-09-14 2020-03-19 The Jackson Laboratory Method and apparatus for detecting copy number variations in a genome
WO2020069350A1 (en) 2018-09-27 2020-04-02 Grail, Inc. Methylation markers and targeted methylation probe panel
AU2019356497A1 (en) * 2018-10-08 2021-03-18 Freenome Holdings, Inc. Transcription factor profiling
CN109523520B (zh) * 2018-10-25 2020-12-18 北京大学第三医院 一种基于深度学习的染色体自动计数方法
EP3874060A1 (en) 2018-10-31 2021-09-08 Guardant Health, Inc. Methods, compositions and systems for calibrating epigenetic partitioning assays
CN109584961A (zh) * 2018-12-03 2019-04-05 元码基因科技（北京）股份有限公司 基于二代测序技术检测血液微卫星不稳定的方法
US11581062B2 (en) 2018-12-10 2023-02-14 Grail, Llc Systems and methods for classifying patients with respect to multiple cancer classes
US20200202975A1 (en) * 2018-12-19 2020-06-25 AiOnco, Inc. Genetic information processing system with mutation analysis mechanism and method of operation thereof
CN109712671B (zh) * 2018-12-20 2020-06-26 北京优迅医学检验实验室有限公司 基于ctDNA的基因检测装置、存储介质及计算机系统
JP2022514010A (ja) 2018-12-20 2022-02-09 ガーダント ヘルス， インコーポレイテッド 核酸分子の回収率を改善するための方法、組成物、およびシステム
CN111383714B (zh) * 2018-12-29 2023-07-28 安诺优达基因科技(北京)有限公司 模拟目标疾病仿真测序文库的方法及其应用
US11643693B2 (en) 2019-01-31 2023-05-09 Guardant Health, Inc. Compositions and methods for isolating cell-free DNA
CN109841265B (zh) * 2019-02-22 2021-09-21 清华大学 使用片段化模式确定血浆游离核酸分子组织来源的方法和系统及应用
US20200273538A1 (en) 2019-02-27 2020-08-27 Guardant Health, Inc. Computational modeling of loss of function based on allelic frequency
WO2020176659A1 (en) 2019-02-27 2020-09-03 Guardant Health, Inc. Methods and systems for determining the cellular origin of cell-free dna
CN111755075B (zh) * 2019-03-28 2023-09-29 深圳华大生命科学研究院 对免疫组库高通量测序样本间序列污染进行过滤的方法
CN110299185B (zh) * 2019-05-08 2023-07-04 西安电子科技大学 一种基于新一代测序数据的插入变异检测方法及系统
WO2020243722A1 (en) * 2019-05-31 2020-12-03 Guardant Health, Inc. Methods and systems for improving patient monitoring after surgery
WO2020252387A2 (en) * 2019-06-12 2020-12-17 Ultima Genomics, Inc. Methods for accurate base calling using molecular barcodes
WO2021067484A1 (en) 2019-09-30 2021-04-08 Guardant Health, Inc. Compositions and methods for analyzing cell-free dna in methylation partitioning assays
CN110578002A (zh) * 2019-10-10 2019-12-17 广州燃石医学检验所有限公司 用于检测循环肿瘤dna突变的质控品及其制备方法
CN114786473B (zh) * 2019-10-10 2023-12-19 嘉士伯有限公司 制备突变植物的方法
EP4048812B1 (en) 2019-10-25 2023-12-06 Guardant Health, Inc. Methods for 3' overhang repair
WO2021077411A1 (zh) * 2019-10-25 2021-04-29 苏州宏元生物科技有限公司 染色体不稳定性检测方法、系统及试剂盒
CA3156589A1 (en) 2019-11-06 2021-05-14 David M. Kurtz Methods and systems for analyzing nucleic acid molecules
CN114746560A (zh) 2019-11-26 2022-07-12 夸登特健康公司 改进甲基化多核苷酸结合的方法、组合物和系统
KR102184277B1 (ko) * 2020-01-16 2020-11-30 성균관대학교산학협력단 초음파 진단 및 dna 검사 일체형 ai 자가 건강 관리 장치 및 이를 이용한 원격 의료 진단 방법
CN115428087A (zh) 2020-01-31 2022-12-02 夸登特健康公司 克隆水平缺乏靶变体的显著性建模
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
EP4118653A1 (en) 2020-03-11 2023-01-18 Guardant Health, Inc. Methods for classifying genetic mutations detected in cell-free nucleic acids as tumor or non-tumor origin
CN111445950B (zh) * 2020-03-19 2022-10-25 西安交通大学 一种基于滤波策略的高容错基因组复杂结构变异检测方法
CN113436679A (zh) * 2020-03-23 2021-09-24 北京合生基因科技有限公司 确定待测核酸样本变异率的方法和系统
EP4143338A1 (en) 2020-04-30 2023-03-08 Guardant Health, Inc. Methods for sequence determination using partitioned nucleic acids
US20220025468A1 (en) 2020-05-14 2022-01-27 Guardant Health, Inc. Homologous recombination repair deficiency detection
WO2021231862A1 (en) * 2020-05-14 2021-11-18 Georgia Tech Research Corporation Methods of detecting the efficacy of anticancer agents
WO2023282916A1 (en) 2021-07-09 2023-01-12 Guardant Health, Inc. Methods of detecting genomic rearrangements using cell free nucleic acids
WO2022026761A1 (en) 2020-07-30 2022-02-03 Guardant Health, Inc. Methods for isolating cell-free dna
DE112021004478T5 (de) 2020-08-25 2023-09-14 Seer, Inc. Zusammensetzungen und verfahren zur bestimmung von proteinen und nukleinsäuren
EP4205126A1 (en) 2020-08-25 2023-07-05 Guardant Health, Inc. Methods and systems for predicting an origin of a variant
US20220068433A1 (en) 2020-08-27 2022-03-03 Guardant Health, Inc. Computational detection of copy number variation at a locus in the absence of direct measurement of the locus
EP4222279A1 (en) 2020-09-30 2023-08-09 Guardant Health, Inc. Methods and systems to improve the signal to noise ratio of dna methylation partitioning assays
EP4232599A1 (en) 2020-10-23 2023-08-30 Guardant Health, Inc. Compositions and methods for analyzing dna using partitioning and base conversion
JP2023551292A (ja) 2020-11-30 2023-12-07 ガーダント ヘルス， インコーポレイテッド メチル化されたポリヌクレオチドを富化するための組成物および方法
EP4267757A1 (en) 2020-12-23 2023-11-01 Guardant Health, Inc. Methods and systems for analyzing methylated polynucleotides
CN112735516A (zh) * 2020-12-29 2021-04-30 上海派森诺生物科技股份有限公司 一种无参考基因组的群体变异检测分析方法
WO2022174109A1 (en) 2021-02-12 2022-08-18 Guardant Health, Inc. Methods and compositions for detecting nucleic acid variants
JP2024513668A (ja) 2021-03-05 2024-03-27 ガーダント ヘルス， インコーポレイテッド 分子応答を分析するための方法および関連する態様
JP2024512372A (ja) 2021-03-09 2024-03-19 ガーダント ヘルス， インコーポレイテッド オフターゲットポリヌクレオチド配列決定データに基づく腫瘍の存在の検出
EP4314329A1 (en) 2021-03-25 2024-02-07 Guardant Health, Inc. Methods and compositions for quantifying immune cell dna
CN113130005B (zh) * 2021-04-12 2022-11-22 中国科学院东北地理与农业生态研究所 一种基于m2群体的候选因果突变位点基因定位的方法
US11783912B2 (en) 2021-05-05 2023-10-10 The Board Of Trustees Of The Leland Stanford Junior University Methods and systems for analyzing nucleic acid molecules
EP4348249A1 (en) 2021-05-28 2024-04-10 Guardant Health, Inc. Compositions and methods for assaying circulating molecules
CN113284555B (zh) * 2021-06-11 2023-08-22 中山大学 一种基因突变网络的构建方法、装置、设备及存储介质
WO2022271730A1 (en) 2021-06-21 2022-12-29 Guardant Health, Inc. Methods and compositions for copy-number informed tissue-of-origin analysis
WO2023283551A1 (en) * 2021-07-06 2023-01-12 Switch Therapeutics Inc. Methods of designing conditional-activatable small interfering rna sensors
WO2023018791A1 (en) * 2021-08-10 2023-02-16 Cornell University Ultra-sensitive liquid biopsy through deep learning empowered whole genome sequencing of plasma
WO2023056065A1 (en) 2021-09-30 2023-04-06 Guardant Health, Inc. Compositions and methods for synthesis and use of probes targeting nucleic acid rearrangements
WO2023056884A1 (en) * 2021-10-04 2023-04-13 The Chinese University Of Hong Kong Sequencing of viral dna for predicting disease relapse
WO2023081722A2 (en) 2021-11-02 2023-05-11 Guardant Health, Inc. Quality control method
WO2023097325A2 (en) * 2021-11-29 2023-06-01 Mammoth Biosciences, Inc. Systems and methods for identifying genetic phenotypes using programmable nucleases
CN114703263B (zh) * 2021-12-20 2023-09-22 北京科迅生物技术有限公司 一种群组染色体拷贝数变异检测方法及装置
WO2023122623A1 (en) 2021-12-21 2023-06-29 Guardant Health, Inc. Methods and systems for combinatorial chromatin-ip sequencing
WO2023122740A1 (en) 2021-12-23 2023-06-29 Guardant Health, Inc. Compositions and methods for detection of metastasis
WO2023197004A1 (en) 2022-04-07 2023-10-12 Guardant Health, Inc. Detecting the presence of a tumor based on methylation status of cell-free nucleic acid molecules
CN114724628B (zh) * 2022-04-24 2022-11-08 华中农业大学 一种对多物种进行多核苷酸变异鉴定和注释的方法
US20230360725A1 (en) 2022-05-09 2023-11-09 Guardant Health, Inc. Detecting degradation based on strand bias
WO2024006908A1 (en) 2022-06-30 2024-01-04 Guardant Health, Inc. Enrichment of aberrantly methylated dna
WO2024020573A1 (en) 2022-07-21 2024-01-25 Guardant Health, Inc. Methods for detection and reduction of sample preparation-induced methylation artifacts
WO2024059840A1 (en) 2022-09-16 2024-03-21 Guardant Health, Inc. Compositions and methods for analyzing soluble proteins
WO2024073508A2 (en) 2022-09-27 2024-04-04 Guardant Health, Inc. Methods and compositions for quantifying immune cell dna
CN115798580B (zh) * 2023-02-10 2023-11-07 北京中仪康卫医疗器械有限公司 基于基因型填补和低深度测序的一体化基因组分析方法

Family Cites Families (273)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US604804A (en) * 1898-05-31 Shuttle for looms
US4725536A (en) 1985-09-19 1988-02-16 Genetics Institute, Inc. Reagent polynucleotide complex with multiple target binding regions, and kit and methods
US6150517A (en) 1986-11-24 2000-11-21 Gen-Probe Methods for making oligonucleotide probes for the detection and/or quantitation of non-viral organisms
US5149625A (en) 1987-08-11 1992-09-22 President And Fellows Of Harvard College Multiplex analysis of DNA
US4942124A (en) 1987-08-11 1990-07-17 President And Fellows Of Harvard College Multiplex sequencing
US5656731A (en) 1987-10-15 1997-08-12 Chiron Corporation Nucleic acid-amplified immunoassay probes
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5925525A (en) 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6309822B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5871928A (en) 1989-06-07 1999-02-16 Fodor; Stephen P. A. Methods for nucleic acid analysis
US5200314A (en) 1990-03-23 1993-04-06 Chiron Corporation Polynucleotide capture assay employing in vitro amplification
AU1248292A (en) 1990-12-06 1992-07-08 Affymax Technologies N.V. Sequencing by hybridization of a target nucleic acid to a matrix of defined oligonucleotides
US6582908B2 (en) 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
US5981179A (en) 1991-11-14 1999-11-09 Digene Diagnostics, Inc. Continuous amplification reaction
US5424413A (en) 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US6020124A (en) 1992-04-27 2000-02-01 Trustees Of Dartmouth College Detection of soluble gene sequences in biological fluids
US5981176A (en) 1992-06-17 1999-11-09 City Of Hope Method of detecting and discriminating between nucleic acid sequences
WO1995000530A1 (en) 1993-06-25 1995-01-05 Affymax Technologies N.V. Hybridization and sequencing of nucleic acids
US5500356A (en) 1993-08-10 1996-03-19 Life Technologies, Inc. Method of nucleic acid sequence selection
US6309823B1 (en) 1993-10-26 2001-10-30 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same
US5681697A (en) 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
CH686982A5 (fr) 1993-12-16 1996-08-15 Maurice Stroun Méthode pour le diagnostic de cancers.
US20030017081A1 (en) 1994-02-10 2003-01-23 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5714330A (en) 1994-04-04 1998-02-03 Lynx Therapeutics, Inc. DNA sequencing by stepwise ligation and cleavage
US6013445A (en) 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US5695934A (en) 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
US5846719A (en) 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US6600996B2 (en) 1994-10-21 2003-07-29 Affymetrix, Inc. Computer-aided techniques for analyzing biological sequences
ATE340866T1 (de) 1994-10-28 2006-10-15 Gen Probe Inc Zusammensetzungen und verfahren für die gleichzeitige detektion und quantifizierung von einer mehrheit spezifischer nuklein säure sequenzen
US5648245A (en) 1995-05-09 1997-07-15 Carnegie Institution Of Washington Method for constructing an oligonucleotide concatamer library by rolling circle replication
US5968740A (en) 1995-07-24 1999-10-19 Affymetrix, Inc. Method of Identifying a Base in a Nucleic Acid
GB9516636D0 (en) 1995-08-14 1995-10-18 Univ London In-situ nucleic acid amplification and detection
US5763175A (en) 1995-11-17 1998-06-09 Lynx Therapeutics, Inc. Simultaneous sequencing of tagged polynucleotides
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
EP0929694A4 (en) 1996-03-15 2002-05-02 Penn State Res Found DETECTION OF TUMOR-RELATED EXTRACELLULAR NUCLEIC ACID USING PLASMA OR BLOOD SERUM USING NUCLEIC ACID AMPLIFICATION TESTS
ES2347854T5 (es) 1996-03-26 2014-07-24 Michael S. Kopreski Método que permite el uso de RNA extracelular extraído de plasma o suero para detectar, monitorizar o evaluar un cáncer
US6458530B1 (en) 1996-04-04 2002-10-01 Affymetrix Inc. Selecting tag nucleic acids
US6300077B1 (en) 1996-08-14 2001-10-09 Exact Sciences Corporation Methods for the detection of nucleic acids
WO1998015644A2 (en) 1996-09-27 1998-04-16 The Chinese University Of Hong Kong Parallel polynucleotide sequencing method
US6124092A (en) 1996-10-04 2000-09-26 The Perkin-Elmer Corporation Multiplex polynucleotide capture methods and compositions
US6117631A (en) 1996-10-29 2000-09-12 Polyprobe, Inc. Detection of antigens via oligonucleotide antibody conjugates
US6046005A (en) 1997-01-15 2000-04-04 Incyte Pharmaceuticals, Inc. Nucleic acid sequencing with solid phase capturable terminators comprising a cleavable linking group
CA2291180A1 (en) 1997-05-23 1998-11-26 Lynx Therapeutics, Inc. System and apparatus for sequential processing of analytes
WO1999028505A1 (en) 1997-12-03 1999-06-10 Curagen Corporation Methods and devices for measuring differential gene expression
EP1114148A4 (en) 1998-08-28 2004-12-22 Invitrogen Corp SYSTEM FOR RAPID HANDLING OF NUCLEIC ACID SEQUENCES
WO2000014282A1 (en) 1998-09-04 2000-03-16 Lynx Therapeutics, Inc. Method of screening for genetic polymorphism
US6503718B2 (en) 1999-01-10 2003-01-07 Exact Sciences Corporation Methods for detecting mutations using primer extension for detecting disease
US6573053B1 (en) 1999-02-05 2003-06-03 Amersham Biosciences Uk Limited Analysis method
US6629040B1 (en) 1999-03-19 2003-09-30 University Of Washington Isotope distribution encoded tags for protein identification
CA2366459A1 (en) 1999-03-26 2000-10-05 Affymetrix, Inc. Universal arrays
US6964846B1 (en) 1999-04-09 2005-11-15 Exact Sciences Corporation Methods for detecting nucleic acids indicative of cancer
US6699661B1 (en) 1999-04-20 2004-03-02 Kankyo Engineering Co., Ltd. Method for determining a concentration of target nucleic acid molecules, nucleic acid probes for the method, and method for analyzing data obtained by the method
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
US6242186B1 (en) 1999-06-01 2001-06-05 Oy Jurilab Ltd. Method for detecting a risk of cancer and coronary heart disease and kit therefor
US6326148B1 (en) 1999-07-12 2001-12-04 The Regents Of The University Of California Detection of copy number changes in colon cancer
US6440706B1 (en) 1999-08-02 2002-08-27 Johns Hopkins University Digital amplification
US6849403B1 (en) 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
US6586177B1 (en) 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
AU4714201A (en) 1999-12-07 2001-06-18 Exact Sciences Corporation Supracolonic aerodigestive neoplasm detection
US6489114B2 (en) 1999-12-17 2002-12-03 Bio Merieux Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby
CA2399733C (en) 2000-02-07 2011-09-20 Illumina, Inc. Nucleic acid detection methods using universal priming
GB2364054B (en) 2000-03-24 2002-05-29 Smithkline Beecham Corp Method of amplifying quinolone-resistance-determining-regions and identifying polymorphic variants thereof
US20030207300A1 (en) 2000-04-28 2003-11-06 Matray Tracy J. Multiplex analytical platform using molecular tags
EP1158055A1 (fr) 2000-05-26 2001-11-28 Xu Qi University of Teaxs Laboratoire de Leucémie Chen Méthode pour le diagnostic de cancers
CA2426824A1 (en) 2000-10-24 2002-07-25 The Board Of Trustees Of The Leland Stanford Junior University Direct multiplex characterization of genomic dna
US20020142345A1 (en) 2000-12-22 2002-10-03 Nelsen Anita J. Methods for encoding and decoding complex mixtures in arrayed assays
US20030049616A1 (en) 2001-01-08 2003-03-13 Sydney Brenner Enzymatic synthesis of oligonucleotide tags
US6849404B2 (en) 2001-05-07 2005-02-01 Bioneer Corporation Polymerase chain reaction of DNA of which base sequence is completely unidentified
US7406385B2 (en) 2001-10-25 2008-07-29 Applera Corporation System and method for consensus-calling with per-base quality values for sample assemblies
DK1342794T3 (da) 2002-03-05 2006-04-24 Epigenomics Ag Fremgangsmåde og anordning til at bestemme vævsspecificitet af fritflydende DNA i legemsvæsker
US20030186251A1 (en) 2002-04-01 2003-10-02 Brookhaven Science Associates, Llc Genome sequence tags
US7727720B2 (en) 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
US7822555B2 (en) 2002-11-11 2010-10-26 Affymetrix, Inc. Methods for identifying DNA copy number changes
WO2004044225A2 (en) 2002-11-11 2004-05-27 Affymetrix, Inc. Methods for identifying dna copy number changes
US10229244B2 (en) 2002-11-11 2019-03-12 Affymetrix, Inc. Methods for identifying DNA copy number changes using hidden markov model based estimations
US7704687B2 (en) 2002-11-15 2010-04-27 The Johns Hopkins University Digital karyotyping
WO2004081183A2 (en) 2003-03-07 2004-09-23 Rubicon Genomics, Inc. In vitro dna immortalization and whole genome amplification using libraries generated from randomly fragmented dna
US20040259118A1 (en) 2003-06-23 2004-12-23 Macevicz Stephen C. Methods and compositions for nucleic acid sequence analysis
EP2918595B1 (en) 2003-07-05 2019-12-11 The Johns-Hopkins University Method and compositions for detection and enumeration of genetic variations
ATE435301T1 (de) 2003-10-16 2009-07-15 Sequenom Inc Nicht invasiver nachweis fötaler genetischer merkmale
DE10348407A1 (de) 2003-10-17 2005-05-19 Widschwendter, Martin, Prof. Prognostische und diagnostische Marker für Zell-proliferative Erkrankungen von Brustgeweben
US20070111233A1 (en) 2003-10-30 2007-05-17 Bianchi Diana W Prenatal diagnosis using cell-free fetal DNA in amniotic fluid
US20080261204A1 (en) 2004-01-23 2008-10-23 Lingvitae As Polynucleotide Ligation Reactions
JP2007521833A (ja) 2004-02-12 2007-08-09 コンパス ジェネティクス エルエルシー 配列特異的分類による遺伝的分析
US20100216153A1 (en) 2004-02-27 2010-08-26 Helicos Biosciences Corporation Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities
US20060046258A1 (en) 2004-02-27 2006-03-02 Lapidus Stanley N Applications of single molecule sequencing
WO2005111242A2 (en) 2004-05-10 2005-11-24 Parallele Bioscience, Inc. Digital profiling of polynucleotide populations
US7276720B2 (en) 2004-07-19 2007-10-02 Helicos Biosciences Corporation Apparatus and methods for analyzing samples
US20060035258A1 (en) 2004-08-06 2006-02-16 Affymetrix, Inc. Methods for identifying DNA copy number changes
US7937225B2 (en) 2004-09-03 2011-05-03 New York University Systems, methods and software arrangements for detection of genome copy number variation
EP1647600A3 (en) 2004-09-17 2006-06-28 Affymetrix, Inc. (A US Entity) Methods for identifying biological samples by addition of nucleic acid bar-code tags
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence
US7424371B2 (en) 2004-12-21 2008-09-09 Helicos Biosciences Corporation Nucleic acid analysis
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
ITRM20050068A1 (it) 2005-02-17 2006-08-18 Istituto Naz Per Le Malattie I Metodo per la rivelazione di acidi nucleici di agenti patogeni batterici o di parassiti nelle urine.
EP1856293A2 (en) 2005-03-16 2007-11-21 Compass Genetics, Llc Methods and compositions for assay readouts on multiple analytical platforms
EP2371453A1 (en) 2005-03-18 2011-10-05 Fluidigm Corporation Microfluidic device
DE602005009324D1 (de) 2005-04-06 2008-10-09 Maurice Stroun Methode zur Krebsdiagnose mittels Nachweis von DNA und RNA im Kreislauf
US20070020640A1 (en) 2005-07-21 2007-01-25 Mccloskey Megan L Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
ATE453728T1 (de) 2005-09-29 2010-01-15 Keygene Nv Screening mutagenisierter populationen mit hohem durchsatz
US7537897B2 (en) 2006-01-23 2009-05-26 Population Genetics Technologies, Ltd. Molecular counting
US20070172839A1 (en) 2006-01-24 2007-07-26 Smith Douglas R Asymmetrical adapters and methods of use thereof
US8383338B2 (en) 2006-04-24 2013-02-26 Roche Nimblegen, Inc. Methods and systems for uniform enrichment of genomic regions
US7702468B2 (en) 2006-05-03 2010-04-20 Population Diagnostics, Inc. Evaluating genetic disorders
CN101449162B (zh) 2006-05-18 2013-07-31 分子压型学会股份有限公司 确定针对病状的个性化医疗介入的系统和方法
US20080090239A1 (en) 2006-06-14 2008-04-17 Daniel Shoemaker Rare cell analysis using sample splitting and dna tags
FR2904833A1 (fr) 2006-08-11 2008-02-15 Bioquanta Sarl Procede de dosage d'acide nuclieque par fluorescence
CA2958994C (en) 2006-11-15 2019-05-07 Biospherex Llc Kit for multiplex sequencing and ecogenomics analysis
WO2008070144A2 (en) 2006-12-06 2008-06-12 Duke University Imprinted genes and disease
CN101711284A (zh) 2007-01-25 2010-05-19 达娜-法勃肿瘤研究所 抗egfr抗体在治疗egfr突变体介导的疾病中的用途
CA2680326A1 (en) 2007-03-13 2008-09-18 Amgen Inc. K-ras mutations and anti-egfr antibody therapy
WO2008148072A2 (en) 2007-05-24 2008-12-04 The Brigham And Women's Hospital, Inc. Disease-associated genetic variations and methods for obtaining and using same
US20090105959A1 (en) 2007-06-01 2009-04-23 Braverman Michael S System and method for identification of individual samples from a multiplex mixture
AU2008261935B2 (en) * 2007-06-06 2013-05-02 Pacific Biosciences Of California, Inc. Methods and processes for calling bases in sequence by incorporation methods
US20100112590A1 (en) 2007-07-23 2010-05-06 The Chinese University Of Hong Kong Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment
CA2693081C (en) 2007-07-23 2016-01-26 The Chinese University Of Hong Kong Diagnosing fetal chromosomal aneuploidy using genomic sequencing
US20090053719A1 (en) 2007-08-03 2009-02-26 The Chinese University Of Hong Kong Analysis of nucleic acids by digital pcr
ATE541946T1 (de) 2007-09-07 2012-02-15 Fluidigm Corp Verfahren und system zur bestimmung von genkopiezahlvarianten
US20100173294A1 (en) 2007-09-11 2010-07-08 Roche Molecular Systems, Inc. Diagnostic test for susceptibility to b-raf kinase inhibitors
US8775092B2 (en) 2007-11-21 2014-07-08 Cosmosid, Inc. Method and system for genome identification
US20110171640A1 (en) 2008-02-12 2011-07-14 Novartis Vaccines And Diagnostics, Inc. Method for isolating cell free apoptotic or fetal nucleic acids
US8216789B2 (en) 2008-02-27 2012-07-10 University Of Washington Diagnostic panel of cancer antibodies and methods for use
US20110003701A1 (en) * 2008-02-27 2011-01-06 454 Life Sciences Corporation System and method for improved processing of nucleic acids for production of sequencable libraries
EP2276858A4 (en) 2008-03-26 2011-10-05 Sequenom Inc RESTRICTED ENDONUCLEASE AMPLIFIED POLYMORPHIC SEQUENCE DETECTION
US8153375B2 (en) 2008-03-28 2012-04-10 Pacific Biosciences Of California, Inc. Compositions and methods for nucleic acid sequencing
US20110160290A1 (en) 2008-05-21 2011-06-30 Muneesh Tewari Use of extracellular rna to measure disease
US20090298709A1 (en) 2008-05-28 2009-12-03 Affymetrix, Inc. Assays for determining telomere length and repeated sequence copy number
DE102008025656B4 (de) 2008-05-28 2016-07-28 Genxpro Gmbh Verfahren zur quantitativen Analyse von Nukleinsäuren, Marker dafür und deren Verwendung
CN102165073A (zh) 2008-07-10 2011-08-24 骆树恩 用于核酸作图和鉴定核酸中的精细结构变化的方法
US20100041048A1 (en) 2008-07-31 2010-02-18 The Johns Hopkins University Circulating Mutant DNA to Assess Tumor Dynamics
US20100062494A1 (en) 2008-08-08 2010-03-11 President And Fellows Of Harvard College Enzymatic oligonucleotide pre-adenylation
WO2010021936A1 (en) 2008-08-16 2010-02-25 The Board Of Trustees Of The Leland Stanford Junior University Digital pcr calibration for high throughput sequencing
WO2010028288A2 (en) 2008-09-05 2010-03-11 Aueon, Inc. Methods for stratifying and annotating cancer drug treatment options
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
SI2562268T1 (sl) 2008-09-20 2017-05-31 The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Building 170 Neinvazivna diagnoza fetalne anevploidije s sekvenciranjem
US8236532B2 (en) 2008-12-23 2012-08-07 Illumina, Inc. Multibase delivery for long reads in sequencing by synthesis protocols
CN102272334B (zh) * 2009-01-13 2014-08-20 关键基因股份有限公司 新基因组测序策略
US20100323348A1 (en) 2009-01-31 2010-12-23 The Regents Of The University Of Colorado, A Body Corporate Methods and Compositions for Using Error-Detecting and/or Error-Correcting Barcodes in Nucleic Acid Amplification Process
US20120165202A1 (en) 2009-04-30 2012-06-28 Good Start Genetics, Inc. Methods and compositions for evaluating genetic markers
WO2010127186A1 (en) 2009-04-30 2010-11-04 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
US20130143747A1 (en) 2011-12-05 2013-06-06 Myriad Genetics, Incorporated Methods of detecting cancer
US9524369B2 (en) 2009-06-15 2016-12-20 Complete Genomics, Inc. Processing and analysis of complex nucleic acid sequence data
RU2014144463A (ru) 2009-06-25 2015-06-20 Фред Хатчинсон Кансэр Рисёч Сентер Способ измерения адаптивного иммунитета
US10017812B2 (en) 2010-05-18 2018-07-10 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20120220478A1 (en) 2009-07-20 2012-08-30 Bar Harbor Biotechnology, Inc. Methods for assessing disease risk
CA2778926C (en) 2009-10-26 2018-03-27 Lifecodexx Ag Means and methods for non-invasive diagnosis of chromosomal aneuploidy
JP2013510580A (ja) 2009-11-12 2013-03-28 エソテリックス ジェネティック ラボラトリーズ， エルエルシー 遺伝子座のコピー数の分析
US20110237444A1 (en) * 2009-11-20 2011-09-29 Life Technologies Corporation Methods of mapping genomic methylation patterns
US9023769B2 (en) 2009-11-30 2015-05-05 Complete Genomics, Inc. cDNA library for nucleic acid sequencing
US9752187B2 (en) 2009-12-11 2017-09-05 Nucleix Categorization of DNA samples
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US9315857B2 (en) 2009-12-15 2016-04-19 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse label-tags
US9926593B2 (en) 2009-12-22 2018-03-27 Sequenom, Inc. Processes and kits for identifying aneuploidy
US20120010085A1 (en) 2010-01-19 2012-01-12 Rava Richard P Methods for determining fraction of fetal nucleic acids in maternal samples
US20120100548A1 (en) * 2010-10-26 2012-04-26 Verinata Health, Inc. Method for determining copy number variations
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
WO2011090559A1 (en) 2010-01-19 2011-07-28 Verinata Health, Inc. Sequencing methods and compositions for prenatal diagnoses
US20110177512A1 (en) 2010-01-19 2011-07-21 Predictive Biosciences, Inc. Method for assuring amplification of an abnormal nucleic acid in a sample
EP2513341B1 (en) 2010-01-19 2017-04-12 Verinata Health, Inc Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing
US9260745B2 (en) 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
WO2011103236A2 (en) 2010-02-18 2011-08-25 The Johns Hopkins University Personalized tumor biomarkers
WO2011115937A1 (en) 2010-03-14 2011-09-22 The Translational Genomics Research Institute Methods of determining susceptibility of tumors to tyrosine kinase inhibitors
CN101967517B (zh) 2010-03-19 2012-11-07 黄乐群 一种无需借助pcr的基因检测方法
CA2796578C (en) 2010-04-16 2021-11-23 Chronix Biomedical Breast cancer associated circulating nucleic acid biomarkers
US9255291B2 (en) 2010-05-06 2016-02-09 Bioo Scientific Corporation Oligonucleotide ligation methods for improving data quality and throughput using massively parallel sequencing
WO2011142836A2 (en) * 2010-05-14 2011-11-17 Fluidigm Corporation Assays for the detection of genotype, mutations, and/or aneuploidy
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US20130143214A1 (en) 2010-06-04 2013-06-06 Chronix Biomedical Prostate cancer associated circulating nucleic acid biomarkers
DK3425062T3 (da) 2010-06-09 2023-09-04 Keygene Nv Stregkoder med kombinatorisk sekvens til høj gennemløbsscreening
EP2400035A1 (en) 2010-06-28 2011-12-28 Technische Universität München Methods and compositions for diagnosing gastrointestinal stromal tumors
US20120046877A1 (en) 2010-07-06 2012-02-23 Life Technologies Corporation Systems and methods to detect copy number variation
JP2013538565A (ja) 2010-07-23 2013-10-17 プレジデント アンド フェロウズ オブ ハーバード カレッジ 体液中の疾患または症状のシグネチャを検出する方法
US9079155B2 (en) 2010-07-29 2015-07-14 Toto Ltd. Photocatalyst coated body and photocatalyst coating liquid
CN103392182B (zh) 2010-08-02 2017-07-04 众有生物有限公司 用于发现遗传疾病中致病突变的系统和方法
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
US11031095B2 (en) * 2010-08-06 2021-06-08 Ariosa Diagnostics, Inc. Assay systems for determination of fetal copy number variation
EP2426217A1 (en) 2010-09-03 2012-03-07 Centre National de la Recherche Scientifique (CNRS) Analytical methods for cell free nucleic acids and applications
US20120231479A1 (en) 2010-09-09 2012-09-13 Robert Puskas Combination methods of diagnosing cancer in a patient
CN103154273A (zh) 2010-09-21 2013-06-12 群体遗传学科技有限公司 通过分子计数提高等位基因调用的置信度
WO2012040387A1 (en) * 2010-09-24 2012-03-29 The Board Of Trustees Of The Leland Stanford Junior University Direct capture, amplification and sequencing of target dna using immobilized primers
WO2012042374A2 (en) 2010-10-01 2012-04-05 Anssi Jussi Nikolai Taipale Method of determining number or concentration of molecules
DK2625320T3 (da) 2010-10-08 2019-07-01 Harvard College High-throughput enkeltcellestregkodning
US8725422B2 (en) 2010-10-13 2014-05-13 Complete Genomics, Inc. Methods for estimating genome-wide copy number variations
EP3702475A1 (en) 2010-10-22 2020-09-02 Cold Spring Harbor Laboratory Varietal counting of nucleic acids for obtaining genomic copy number information
WO2012066451A1 (en) 2010-11-15 2012-05-24 Pfizer Inc. Prognostic and predictive gene signature for colon cancer
TW202242133A (zh) 2010-11-30 2022-11-01 香港中文大學 與癌症有關之基因或分子變異之檢測
CN103608466B (zh) 2010-12-22 2020-09-18 纳特拉公司 非侵入性产前亲子鉴定方法
CA2822439A1 (en) * 2010-12-23 2012-06-28 Sequenom, Inc. Fetal genetic variation detection
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
EP3225697A3 (en) 2010-12-30 2017-11-22 Foundation Medicine, Inc. Optimization of multigene analysis of tumor samples
US20140011694A1 (en) 2011-01-11 2014-01-09 Via Genomes, Inc. Methods, systems, databases, kits and arrays for screening for and predicting the risk of an identifying the presence of tumors and cancers
US20120190021A1 (en) 2011-01-25 2012-07-26 Aria Diagnostics, Inc. Detection of genetic abnormalities
US20140024539A1 (en) * 2011-02-02 2014-01-23 Translational Genomics Research Institute Biomarkers and methods of use thereof
US20120238464A1 (en) 2011-03-18 2012-09-20 Baylor Research Institute Biomarkers for Predicting the Recurrence of Colorectal Cancer Metastasis
WO2012129363A2 (en) 2011-03-24 2012-09-27 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
US20150065358A1 (en) 2011-03-30 2015-03-05 Verinata Health, Inc. Method for verifying bioassay samples
US9411937B2 (en) 2011-04-15 2016-08-09 Verinata Health, Inc. Detecting and classifying copy number variation
CN103748236B (zh) 2011-04-15 2018-12-25 约翰·霍普金斯大学 安全测序系统
JP2014512826A (ja) 2011-04-25 2014-05-29 バイオ−ラド ラボラトリーズ インコーポレイテッド 核酸分析のための方法および組成物
LT2705157T (lt) 2011-05-06 2017-03-10 New England Biolabs, Inc. Ligavimo pagerinimas
CN112592960A (zh) 2011-05-20 2021-04-02 富鲁达公司 核酸编码反应
US9752176B2 (en) 2011-06-15 2017-09-05 Ginkgo Bioworks, Inc. Methods for preparative in vitro cloning
WO2013019075A2 (ko) 2011-08-01 2013-02-07 연세대학교산학협력단 핵산분자의 제조방법
US10704164B2 (en) 2011-08-31 2020-07-07 Life Technologies Corporation Methods, systems, computer readable media, and kits for sample identification
WO2013033721A1 (en) 2011-09-02 2013-03-07 Atreca, Inc. Dna barcodes for multiplexed sequencing
US8712697B2 (en) 2011-09-07 2014-04-29 Ariosa Diagnostics, Inc. Determination of copy number variations using binomial probability calculations
US20130079241A1 (en) 2011-09-15 2013-03-28 Jianhua Luo Methods for Diagnosing Prostate Cancer and Predicting Prostate Cancer Relapse
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140242588A1 (en) 2011-10-06 2014-08-28 Sequenom, Inc Methods and processes for non-invasive assessment of genetic variations
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20130102485A1 (en) 2011-10-19 2013-04-25 Inhan Lee Method of Determining a Diseased State in a Subject
NO3051026T3 (es) 2011-10-21 2018-07-28
CA2852098C (en) 2011-10-21 2023-05-02 Chronix Biomedical Colorectal cancer associated circulating nucleic acid biomarkers
US20130122499A1 (en) 2011-11-14 2013-05-16 Viomics, Inc. System and method of detecting local copy number variation in dna samples
WO2013086352A1 (en) 2011-12-07 2013-06-13 Chronix Biomedical Prostate cancer associated circulating nucleic acid biomarkers
WO2013086424A1 (en) 2011-12-08 2013-06-13 Five3 Genomics, Llc Mdm2-containing double minute chromosomes and methods therefore
WO2013106737A1 (en) 2012-01-13 2013-07-18 Data2Bio Genotyping by next-generation sequencing
ES2665071T3 (es) 2012-02-17 2018-04-24 Fred Hutchinson Cancer Research Center Composiciones y métodos para identificar mutaciones de manera precisa
GB2513024B (en) 2012-02-27 2016-08-31 Cellular Res Inc A clonal amplification method
US11177020B2 (en) 2012-02-27 2021-11-16 The University Of North Carolina At Chapel Hill Methods and uses for molecular tags
US9670529B2 (en) 2012-02-28 2017-06-06 Population Genetics Technologies Ltd. Method for attaching a counter sequence to a nucleic acid sample
WO2013130791A1 (en) 2012-02-29 2013-09-06 Dana-Farber Cancer Institute, Inc. Compositions, kits, and methods for the identification, assessment, prevention, and therapy of cancer
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
EP2825675B1 (en) 2012-03-13 2017-12-27 Patel, Abhijit Ajit Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing
PT2828218T (pt) 2012-03-20 2020-11-11 Univ Washington Through Its Center For Commercialization Métodos para baixar a taxa de erro da sequenciação paralela massiva de adn utilizando sequenciação duplex de consensus
WO2013142213A1 (en) 2012-03-20 2013-09-26 Wake Forest University Health Sciences Methods, systems, and computer readable media for tracking and verifying receipt of contents of a delivery within an organization
FI2831279T3 (fi) 2012-03-26 2023-05-23 Univ Johns Hopkins Nopea aneuploidian havaitseminen
US8209130B1 (en) * 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
US10385396B2 (en) 2012-04-19 2019-08-20 The Medical College Of Wisconsin, Inc. Highly sensitive surveillance using detection of cell free DNA
PT2850211T (pt) 2012-05-14 2021-11-29 Irepertoire Inc Método para aumentar a precisão na deteção quantitativa de polinucleótidos
EP2855707B1 (en) 2012-05-31 2017-07-12 Board Of Regents, The University Of Texas System Method for accurate sequencing of dna
CN104520443A (zh) 2012-06-11 2015-04-15 赛昆塔公司 使用序列标签的序列确定方法
US11261494B2 (en) 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
WO2014004726A1 (en) 2012-06-26 2014-01-03 Caifu Chen Methods, compositions and kits for the diagnosis, prognosis and monitoring of cancer
EP2877594B1 (en) 2012-07-20 2019-12-04 Verinata Health, Inc. Detecting and classifying copy number variation in a fetal genome
US20140066317A1 (en) 2012-09-04 2014-03-06 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
KR20240007774A (ko) 2012-09-04 2024-01-16 가던트 헬쓰, 인크. 희귀 돌연변이 및 카피수 변이를 검출하기 위한 시스템 및 방법
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
EP4293125A3 (en) 2012-12-10 2024-02-28 Resolution Bioscience, Inc. Methods for targeted genomic analysis
EP3822809A1 (en) 2013-01-05 2021-05-19 Foundation Medicine, Inc. System and method for outcome tracking and analysis
EP2945652B1 (en) 2013-01-18 2021-07-07 Foundation Medicine, Inc. Methods of treating cholangiocarcinoma
US20160034638A1 (en) 2013-03-14 2016-02-04 University Of Rochester System and Method for Detecting Population Variation from Nucleic Acid Sequencing Data
CN105408496A (zh) * 2013-03-15 2016-03-16 夸登特健康公司 检测稀有突变和拷贝数变异的系统和方法
AU2014233373B2 (en) 2013-03-15 2019-10-24 Verinata Health, Inc. Generating cell-free DNA libraries directly from blood
US10119134B2 (en) * 2013-03-15 2018-11-06 Abvitro Llc Single cell bar-coding for antibody discovery
WO2014151511A2 (en) 2013-03-15 2014-09-25 Abbott Molecular Inc. Systems and methods for detection of genomic copy number changes
ES2946689T3 (es) 2013-03-15 2023-07-24 Univ Leland Stanford Junior Identificación y uso de marcadores tumorales de ácido nucleico circulante
JP6520705B2 (ja) 2013-03-19 2019-05-29 凸版印刷株式会社 Ｅｇｆｒ阻害剤感受性予測方法
EP2999792B1 (en) 2013-05-23 2018-11-14 The Board of Trustees of The Leland Stanford Junior University Transposition into native chromatin for personal epigenomics
JP2015096049A (ja) 2013-11-15 2015-05-21 凸版印刷株式会社 Ｖｅｇｆ阻害剤長期奏功性予測方法
CN111534580A (zh) 2013-12-28 2020-08-14 夸登特健康公司 用于检测遗传变异的方法和系统
US11203784B2 (en) 2014-04-14 2021-12-21 Hadasit Medical Research Services And Development Ltd. Method and kit for determining the tissue or cell origin of DNA
EP3143163B1 (en) 2014-05-13 2020-11-25 Board of Regents, The University of Texas System Gene mutations and copy number alterations of egfr, kras and met
RU2699728C2 (ru) 2014-07-25 2019-09-09 БиДжиАй Дженомикс Ко., Лтд. Способ и устройство для определения фракции внеклеточных нуклеиновых кислот в биологическом образце и их применение
KR20220127359A (ko) 2014-07-25 2022-09-19 유니버시티 오브 워싱톤 무세포 dna를 생성하는 조직 및/또는 세포 유형을 결정하는 방법 및 이를 사용하여 질환 또는 장애를 확인하는 방법
US20160053301A1 (en) 2014-08-22 2016-02-25 Clearfork Bioscience, Inc. Methods for quantitative genetic analysis of cell free dna
EP3192047A4 (en) 2014-09-10 2018-03-28 Pathway Genomics Corporation Health and wellness management methods and systems useful for the practice thereof
ES2925014T3 (es) 2014-09-12 2022-10-13 Univ Leland Stanford Junior Identificación y uso de ácidos nucleicos circulantes
AU2016218631B2 (en) 2015-02-10 2022-03-10 The Chinese University Of Hong Kong Detecting mutations for cancer screening and fetal analysis
US10844428B2 (en) 2015-04-28 2020-11-24 Illumina, Inc. Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS)
CN109072294A (zh) 2015-12-08 2018-12-21 特温斯特兰德生物科学有限公司 用于双重测序的改良衔接子、方法和组合物
US20190085406A1 (en) 2016-04-14 2019-03-21 Guardant Health, Inc. Methods for early detection of cancer

Also Published As

Publication number Publication date
CA2883901A1 (en) 2014-03-13
US10793916B2 (en) 2020-10-06
IL237480B (en) 2019-10-31
ES2906714T3 (es) 2022-04-20
US11773453B2 (en) 2023-10-03
US20210130912A1 (en) 2021-05-06
US10738364B2 (en) 2020-08-11
US20170218459A1 (en) 2017-08-03
US10947600B2 (en) 2021-03-16
US20220042104A1 (en) 2022-02-10
MX2015002769A (es) 2015-08-14
US9834822B2 (en) 2017-12-05
PT2893040T (pt) 2019-04-01
US20180171415A1 (en) 2018-06-21
CN110872617A (zh) 2020-03-10
US10876172B2 (en) 2020-12-29
US20210032707A1 (en) 2021-02-04
EP3470533B2 (en) 2023-01-18
GB2533006A (en) 2016-06-08
US20200087736A1 (en) 2020-03-19
WO2014039556A1 (en) 2014-03-13
US20190177803A1 (en) 2019-06-13
US10822663B2 (en) 2020-11-03
HK1225416B (zh) 2017-09-08
SG10202000486VA (en) 2020-03-30
ES2769241T5 (es) 2023-05-30
JP7119014B2 (ja) 2022-08-16
US9598731B2 (en) 2017-03-21
IL269097A (en) 2019-11-28
US10494678B2 (en) 2019-12-03
CA2883901C (en) 2023-04-11
KR102210852B1 (ko) 2021-02-01
JP2018027096A (ja) 2018-02-22
JP2022169566A (ja) 2022-11-09
US20170218460A1 (en) 2017-08-03
IL237480A0 (en) 2015-04-30
US10501810B2 (en) 2019-12-10
US10457995B2 (en) 2019-10-29
EP3842551A1 (en) 2021-06-30
KR20190112843A (ko) 2019-10-07
CN104781421A (zh) 2015-07-15
US10876171B2 (en) 2020-12-29
IL305303A (en) 2023-10-01
DK2893040T3 (en) 2019-03-11
KR20210013317A (ko) 2021-02-03
KR20220061271A (ko) 2022-05-12
CA3190199A1 (en) 2014-03-13
EP4036247B1 (en) 2024-04-10
GB2533006B (en) 2017-06-07
US20190177802A1 (en) 2019-06-13
PL3591073T3 (pl) 2022-03-28
US10837063B2 (en) 2020-11-17
US20190185941A1 (en) 2019-06-20
EP3842551B1 (en) 2023-11-01
EP3470533A1 (en) 2019-04-17
ES2769241T3 (es) 2020-06-25
US20150368708A1 (en) 2015-12-24
US20210139998A1 (en) 2021-05-13
EP3591073B1 (en) 2021-12-01
JP2015535681A (ja) 2015-12-17
US20200248270A1 (en) 2020-08-06
EP4036247A1 (en) 2022-08-03
CN104781421B (zh) 2020-06-05
EP3842551C0 (en) 2023-11-01
EP2893040B1 (en) 2019-01-02
US20200291487A1 (en) 2020-09-17
GB201509071D0 (en) 2015-07-08
US20180327862A1 (en) 2018-11-15
JP6275145B2 (ja) 2018-02-07
KR102393608B1 (ko) 2022-05-03
KR20240007774A (ko) 2024-01-16
EP2893040A1 (en) 2015-07-15
HK1201080A1 (zh) 2015-08-21
US11319597B2 (en) 2022-05-03
US10501808B2 (en) 2019-12-10
US20150299812A1 (en) 2015-10-22
US20210340632A1 (en) 2021-11-04
US9840743B2 (en) 2017-12-12
US20180223374A1 (en) 2018-08-09
US10961592B2 (en) 2021-03-30
ES2711635T3 (es) 2019-05-06
IL269097B1 (en) 2023-09-01
US20230151435A1 (en) 2023-05-18
PL2893040T3 (pl) 2019-05-31
HK1212396A1 (en) 2016-06-10
US10041127B2 (en) 2018-08-07
US11001899B1 (en) 2021-05-11
US20200299785A1 (en) 2020-09-24
US11879158B2 (en) 2024-01-23
EP3591073A1 (en) 2020-01-08
US11319598B2 (en) 2022-05-03
SG11201501662TA (en) 2015-05-28
DK2893040T5 (en) 2019-03-18
JP6664025B2 (ja) 2020-03-13
US10683556B2 (en) 2020-06-16
KR20150067161A (ko) 2015-06-17
EP3470533B1 (en) 2019-11-06
US20200087735A1 (en) 2020-03-19
KR102028375B1 (ko) 2019-10-04
US20190185940A1 (en) 2019-06-20
US10995376B1 (en) 2021-05-04
DE202013012824U1 (de) 2020-03-10
BR112015004847A2 (pt) 2020-04-22
JP2020103298A (ja) 2020-07-09
US20210355549A1 (en) 2021-11-18
EP2893040A4 (en) 2016-04-27
US20220205051A1 (en) 2022-06-30
IL269097B2 (en) 2024-01-01
JP2020000237A (ja) 2020-01-09
US20230323477A1 (en) 2023-10-12

Similar Documents

Publication Publication Date Title
MX367963B (es) Métodos para detectar mutaciones raras y variación en el número de copias.
GB2528205A (en) Systems and methods to detect rare mutations and copy number variation
BR112015032031A8 (pt) método para estimar uma fração de ácido nucleico em uma amostra de teste de uma mulher grávida
EP2561103A4 (en) NON-INVASIVE DETECTION OF F TAL GENETIC ANOMALIES
GB2519906A (en) Methods and systems for detecting biological components
EA201590027A1 (ru) Способы детекции заболеваний или состояний
WO2014145820A3 (en) Multiple tagging of long dna fragments
BR112013001752A2 (pt) método de detectar doenças ou condições usando células fagocídicas
WO2014144713A3 (en) Methods of sequencing the immune repertoire
GB2526736A (en) Methods, compositions, and kits for nucleic acid analysis
SG10201906331TA (en) Methods for profiling and quantitating cell-free rna
EA201400117A1 (ru) Способы и нуклеиновые кислоты для определения прогноза у больных раком
WO2012159025A3 (en) Chromosome conformation analysis
IN2015MN00457A (es)
AU2012262364A8 (en) Systems and methods for genetic and biological analysis
NZ615154A (en) Micro-organism threat detection
NZ630278A (en) Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors
EP2576837A4 (en) CIRCULATING NUCLEIC ACID BIOMARKERS ASSOCIATED WITH PROSTATE CANCER
BR112017013667A2 (pt) aparelho, sistema, e, método para determinação de afastamento.
PH12018501507A1 (en) Bead beating tube and method for extracting deoxyribonucleic acid and/or ribonucleic acid from microorganisms
NZ628813A (en) Methods for predicting anti-cancer response
WO2015066341A3 (en) Pathogenesis quantification systems and treatment methods for citrus greening blight
WO2014209597A3 (en) Massively parallel sequencing of random dna fragments for determination of fetal fraction
HK1221745A1 (zh) 同時進行單體型分析和染色體非整倍性檢測的方法和系統
MX2014016036A (es) Sistemas, metodos y equipo para determinar la presencia de fluidos de interes.

Legal Events

Date Code Title Description
FG Grant or registration