ATE453728T1 - Screening mutagenisierter populationen mit hohem durchsatz - Google Patents

Screening mutagenisierter populationen mit hohem durchsatz

Info

Publication number
ATE453728T1
ATE453728T1 AT06783930T AT06783930T ATE453728T1 AT E453728 T1 ATE453728 T1 AT E453728T1 AT 06783930 T AT06783930 T AT 06783930T AT 06783930 T AT06783930 T AT 06783930T AT E453728 T1 ATE453728 T1 AT E453728T1
Authority
AT
Austria
Prior art keywords
identification
throughput screening
mutagenized populations
libraries
mutations
Prior art date
Application number
AT06783930T
Other languages
English (en)
Inventor
Eijk Michael Van
Tunen Adrianus Van
Original Assignee
Keygene Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37709618&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE453728(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Keygene Nv filed Critical Keygene Nv
Application granted granted Critical
Publication of ATE453728T1 publication Critical patent/ATE453728T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6846—Common amplification features
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • C12Q1/6855—Ligating adaptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/13—Plant traits

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nanotechnology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT06783930T 2005-09-29 2006-09-21 Screening mutagenisierter populationen mit hohem durchsatz ATE453728T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72152805P 2005-09-29 2005-09-29
PCT/NL2006/000467 WO2007037678A2 (en) 2005-09-29 2006-09-21 High throughput screening of mutagenized populations

Publications (1)

Publication Number Publication Date
ATE453728T1 true ATE453728T1 (de) 2010-01-15

Family

ID=37709618

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06783930T ATE453728T1 (de) 2005-09-29 2006-09-21 Screening mutagenisierter populationen mit hohem durchsatz

Country Status (11)

Country Link
US (12) US20090170713A1 (de)
EP (1) EP1929039B2 (de)
JP (1) JP5237099B2 (de)
CN (1) CN101313078B (de)
AT (1) ATE453728T1 (de)
AU (1) AU2006295556B2 (de)
CA (2) CA2623539C (de)
DE (1) DE602006011486D1 (de)
DK (1) DK1929039T4 (de)
ES (1) ES2338459T5 (de)
WO (1) WO2007037678A2 (de)

Families Citing this family (161)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3257949A1 (de) 2005-06-15 2017-12-20 Complete Genomics Inc. Nukleinsäureanalyse durch zufällige mischungen von nichtüberlappenden fragmenten
DE602006018744D1 (de) 2005-06-23 2011-01-20 Keygene Nv Strategien mit hohem durchsatz zur identifizierung und zum nachweis von polymorphismen
US10316364B2 (en) 2005-09-29 2019-06-11 Keygene N.V. Method for identifying the source of an amplicon
US20090170713A1 (en) * 2005-09-29 2009-07-02 Keygene N.V. High throughput screening of mutagenized populations
ES2558124T3 (es) 2005-12-22 2016-02-02 Keygene N.V. Procedimiento para detección de polimorfismos basada en AFLP de alto rendimiento
ES2829295T3 (es) 2006-04-04 2021-05-31 Keygene Nv Detección de alto rendimiento de marcadores moleculares basados en AFLP y secuenciación de alto rendimiento
EP2082063B1 (de) * 2006-11-15 2014-05-07 Biospherex LLC Multi-tag-sequenzieren und ökogenomik-analyse
AU2008303999B2 (en) * 2007-09-24 2014-07-24 Keygene N.V. Method for the selection of plants with specific mutations
US20100323353A1 (en) * 2007-11-27 2010-12-23 Marc Zabeau Marker assisted directed evolution
US8592150B2 (en) 2007-12-05 2013-11-26 Complete Genomics, Inc. Methods and compositions for long fragment read sequencing
WO2010027870A2 (en) * 2008-08-26 2010-03-11 Fluidigm Corporation Assay methods for increased throughput of samples and/or targets
CN102245784A (zh) * 2008-11-17 2011-11-16 凯津公司 大突变分析(bma)
WO2010057525A1 (en) * 2008-11-19 2010-05-27 Fondazione Parco Tecnologico Padano Oligonucleotide primers for nucleotide indexing of polymorphic pcr products and methods for their use
CN104611360B (zh) 2008-12-05 2017-06-30 关键基因股份有限公司 法尼烯合酶
EP2789694A1 (de) 2009-04-02 2014-10-15 Fluidigm Corporation Mikrofluidische Vorrichtung mit Reaktionsproduktrückgewinnungssystem
WO2010126356A1 (en) * 2009-04-29 2010-11-04 Hendrix Genetics B.V. Method of pooling samples for performing a biological assay
WO2010127186A1 (en) 2009-04-30 2010-11-04 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
CN102459592B (zh) * 2009-06-15 2017-04-05 考利达基因组股份有限公司 用于长片段阅读测序的方法和组合物
JP2013510589A (ja) 2009-11-16 2013-03-28 ゲノミクトリー インコーポレーテッド ジェノタイピング方法
EP2513332A1 (de) * 2009-12-18 2012-10-24 Keygene N.V. Verbesserte bulked-mutant-analyse
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
DK2556171T3 (en) 2010-04-05 2015-12-14 Prognosys Biosciences Inc Spatially CODED BIOLOGICAL ASSAYS
EP4242327A3 (de) 2010-06-09 2023-11-29 Keygene N.V. Strichkodes mit kombinatorischer sequenz für hochdurchsatz screening
CN101921841B (zh) * 2010-06-30 2014-03-12 深圳华大基因科技有限公司 基于Illumina GA测序技术的HLA基因高分辨率分型方法
CN101921840B (zh) * 2010-06-30 2014-06-25 深圳华大基因科技有限公司 一种基于dna分子标签技术和dna不完全打断策略的pcr测序方法
SG186876A1 (en) * 2010-06-30 2013-02-28 Bgi Shenzhen Co Ltd New pcr sequencing method and use thereof in hla genotyping
CN101921842B (zh) * 2010-06-30 2013-08-07 深圳华大基因科技有限公司 Hla-a,b基因分型用pcr引物及其使用方法
WO2012008831A1 (en) * 2010-07-13 2012-01-19 Keygene N.V. Simplified de novo physical map generation from clone libraries
CN102409047B (zh) * 2010-09-21 2014-07-23 深圳华大基因科技服务有限公司 一种构建杂交测序文库的方法
CN103562407A (zh) * 2011-02-09 2014-02-05 伯乐生命医学产品有限公司 核酸的分析
US9260753B2 (en) 2011-03-24 2016-02-16 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
US9487825B2 (en) 2011-05-13 2016-11-08 Mount Sinai School Of Medicine Pooled adapter strategy for reducing bias in small RNA characterization
US9074204B2 (en) 2011-05-20 2015-07-07 Fluidigm Corporation Nucleic acid encoding reactions
WO2012169893A1 (en) 2011-06-10 2012-12-13 Stichting Technologisch Topinstituut Groene Genetica (Foundation Technological Top Institute Green Genetics) Transcription factor modulating terpene biosynthesis
US20150045258A1 (en) * 2012-02-14 2015-02-12 Gnubio, Inc. Cascaded addition of target specific universal adapters to nucleic acids
EP3363901B1 (de) 2012-02-17 2020-12-30 Fred Hutchinson Cancer Research Center Zusammensetzungen und verfahren zur genauen identifizierung von mutationen
DK2828218T3 (da) 2012-03-20 2020-11-02 Univ Washington Through Its Center For Commercialization Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing
JP2015519900A (ja) 2012-05-21 2015-07-16 フリューダイム・コーポレイション 粒子集団の単粒子解析方法及び単粒子単離方法
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
JP2014023434A (ja) * 2012-07-24 2014-02-06 Lotte Co Ltd デンタルプラークの細菌叢の解析方法
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
IL269097B2 (en) 2012-09-04 2024-01-01 Guardant Health Inc Systems and methods to detect rare mutations and copy number variation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
WO2014060483A1 (en) 2012-10-17 2014-04-24 Spatial Transcriptomics Ab Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
KR101600902B1 (ko) 2012-12-11 2016-03-10 주식회사 셀레믹스 코돈 조합화 및 변이유발을 이용한 유전자 라이브러리의 합성 방법
CA2874535C (en) 2013-03-08 2016-03-08 Vineland Research and Innovations Centre Inc. High throughput method of screening a population for members comprising mutation(s) in a target sequence
US20140274738A1 (en) 2013-03-15 2014-09-18 Nugen Technologies, Inc. Sequential sequencing
US11859171B2 (en) 2013-04-17 2024-01-02 Agency For Science, Technology And Research Method for generating extended sequence reads
US9868979B2 (en) 2013-06-25 2018-01-16 Prognosys Biosciences, Inc. Spatially encoded biological assays using a microfluidic device
EP3024948B1 (de) 2013-07-25 2020-01-15 Bio-rad Laboratories, Inc. Genetische tests zur bestimmung einer viralen rekombinationsfrequenz
JP2015035212A (ja) * 2013-07-29 2015-02-19 アジレント・テクノロジーズ・インクＡｇｉｌｅｎｔ Ｔｅｃｈｎｏｌｏｇｉｅｓ， Ｉｎｃ． ターゲットシークエンシングパネルから変異を見つける方法
WO2015073711A1 (en) 2013-11-13 2015-05-21 Nugen Technologies, Inc. Compositions and methods for identification of a duplicate sequencing read
EP3074528A1 (de) * 2013-11-26 2016-10-05 Qiagen GmbH Erzeugung von ligationsbereiten dna-amplicons
EP3077539B8 (de) 2013-12-02 2018-10-10 Personal Genome Diagnostics Inc. Verfahren zur evaluierung von minderheitenvarianten in einer probe
CN103617375B (zh) * 2013-12-02 2017-08-25 深圳华大基因健康科技有限公司 聚合酶链式反应产物测序分型的方法及系统
EP3378952B1 (de) 2013-12-28 2020-02-05 Guardant Health, Inc. Verfahren und systeme für den nachweis genetischer varianten
WO2016012346A1 (en) 2014-07-25 2016-01-28 Enza Zaden Beheer B.V. Stay green cucumber plant
US10233490B2 (en) 2014-11-21 2019-03-19 Metabiotech Corporation Methods for assembling and reading nucleic acid sequences from mixed populations
EP4282977B1 (de) 2015-04-10 2024-06-05 10x Genomics Sweden AB Räumlich getrennte multiplex-nukleinsäureanalyse von biologischen proben
CN107849600A (zh) 2015-06-09 2018-03-27 生命技术公司 用于分子标记的方法、系统、组合物、试剂盒、装置和计算机可读媒体
AU2016331021B2 (en) 2015-10-02 2022-10-27 Keygene N.V. Method for the production of haploid and subsequent doubled haploid plants
BR112018006569A2 (pt) 2015-10-02 2018-12-11 Keygene Nv método para a produção de plantas haploides e subsequentes haploides duplicadas
CA2911002C (en) 2015-11-04 2016-11-29 Travis Wilfred BANKS High throughput method of screening a population for members comprising mutations(s) in a target sequence using alignment-free sequence analysis
PT3387152T (pt) 2015-12-08 2022-04-19 Twinstrand Biosciences Inc Adaptadores, métodos e composições melhorados para sequenciamento duplex
US11117113B2 (en) 2015-12-16 2021-09-14 Fluidigm Corporation High-level multiplex amplification
WO2017106768A1 (en) 2015-12-17 2017-06-22 Guardant Health, Inc. Methods to determine tumor gene copy number by analysis of cell-free dna
EP3199642A1 (de) 2016-02-01 2017-08-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Pflanzenzucht mithilfe von sequenzierung mit grossem durchsatz
CN105734130B (zh) * 2016-03-11 2019-10-25 中国农业科学院生物技术研究所 全基因组范围的植物基因功能鉴定的方法
US11384382B2 (en) 2016-04-14 2022-07-12 Guardant Health, Inc. Methods of attaching adapters to sample nucleic acids
ES3002715T3 (en) 2016-04-14 2025-03-07 Guardant Health Inc Methods for early detection of cancer
JP2019516373A (ja) 2016-05-20 2019-06-20 キージーン ナムローゼ フェンノートシャップ 半数体及びそれに続く倍加半数体植物の産生方法
KR20240155386A (ko) 2016-09-30 2024-10-28 가던트 헬쓰, 인크. 무세포 핵산의 다중-해상도 분석 방법
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
WO2018183942A1 (en) 2017-03-31 2018-10-04 Grail, Inc. Improved library preparation and use thereof for sequencing-based error correction and/or variant identification
US12492430B2 (en) 2017-04-11 2025-12-09 Tecan Genomics, Inc. Library quantitation and qualification
US10633651B2 (en) 2017-07-10 2020-04-28 Agilent Technologies, Inc. Assay methods and compositions for detecting contamination of nucleic acid identifiers
US11505826B2 (en) 2017-07-12 2022-11-22 Agilent Technologies, Inc. Sequencing method for genomic rearrangement detection
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
EP3707273B1 (de) 2017-11-08 2024-04-10 Twinstrand Biosciences, Inc. Reagenzien und adapter zur nukleinsäuresequenzierung und verfahren zur herstellung solcher reagenzien und adapter
WO2019121603A1 (en) 2017-12-18 2019-06-27 Keygene N.V. Chemical mutagenesis of cassava
CN108315396B (zh) * 2018-03-28 2021-07-16 潍坊兴旺生物种业有限公司 一种简单便捷检测snp的新方法
GB2587939B (en) 2018-04-02 2023-06-14 Grail Llc Methylation markers and targeted methylation probe panels
EP3802864A1 (de) 2018-06-06 2021-04-14 The Regents Of The University Of California Verfahren zur herstellung von nukleinsäurebibliotheken und zusammensetzungen und kits zur durchführung davon
KR20210059694A (ko) 2018-07-12 2021-05-25 트윈스트랜드 바이오사이언시스, 인코포레이티드 게놈 편집, 클론 팽창 및 연관된 분야를 규명하기 위한 방법 및 시약
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
US20200075123A1 (en) 2018-08-31 2020-03-05 Guardant Health, Inc. Genetic variant detection based on merged and unmerged reads
CA3111887A1 (en) 2018-09-27 2020-04-02 Grail, Inc. Methylation markers and targeted methylation probe panel
US10945844B2 (en) 2018-10-10 2021-03-16 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
JP7530355B2 (ja) 2018-11-28 2024-08-07 キージーン ナムローゼ フェンノートシャップ エンドヌクレアーゼ保護による標的化濃縮
JP2020080761A (ja) * 2018-11-28 2020-06-04 大成建設株式会社 植物種の地域性変異特定方法
US12529094B2 (en) 2018-12-10 2026-01-20 10X Genomics, Inc. Imaging system hardware
WO2020123311A2 (en) 2018-12-10 2020-06-18 10X Genomics, Inc. Resolving spatial arrays using deconvolution
US11358137B2 (en) 2018-12-26 2022-06-14 Industrial Technology Research Institute Tubular structure for producing droplets and method for producing droplets
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
EP3918089B1 (de) 2019-01-31 2025-01-15 Guardant Health, Inc. Verfahren zur isolierung und sequenzierung zellfreier dna
CN113474466A (zh) 2019-02-21 2021-10-01 主基因有限公司 多倍体基因分型
WO2020239186A1 (en) 2019-05-24 2020-12-03 Enza Zaden Beheer B.V. Downy mildew resistant melon plants
WO2020243579A1 (en) 2019-05-30 2020-12-03 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
EP4025711A2 (de) 2019-11-08 2022-07-13 10X Genomics, Inc. Erhöhung der spezifität einer analytbindung
CN110904258B (zh) * 2019-12-03 2021-08-17 湖南杂交水稻研究中心 一种高通量靶向鉴定理化诱变植株m1代突变及获取突变体的方法
JP7503134B2 (ja) * 2019-12-03 2024-06-19 湖南雑交水稲研究中心 物理的及び化学的突然変異誘発植物のｍ１世代突然変異を同定する方法、と突然変異体を取得する方法、及びイネの突然変異同定用のタイピングプライマー、突然変異遺伝子及び使用
WO2021116371A1 (en) 2019-12-12 2021-06-17 Keygene N.V. Semi-solid state nucleic acid manipulation
EP4077661A1 (de) 2019-12-20 2022-10-26 Keygene N.V. Herstellung von ngs-bibliotheken unter verwendung von kovalent verschlossenen nukleinsäuremolekül-enden.
US12241890B2 (en) 2019-12-23 2025-03-04 10X Genomics, Inc. Methods for generating barcoded nucleic acid molecules using fixed cells
CN115135984B (zh) 2019-12-23 2025-12-23 10X基因组学有限公司 可逆固定试剂及其使用方法
DK3891300T3 (da) 2019-12-23 2023-05-22 10X Genomics Inc Fremgangsmåder til rumlig analyse ved anvendelse af rna-template-ligering
US12365942B2 (en) 2020-01-13 2025-07-22 10X Genomics, Inc. Methods of decreasing background on a spatial array
US12405264B2 (en) 2020-01-17 2025-09-02 10X Genomics, Inc. Electrophoretic system and method for analyte capture
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US20210230681A1 (en) 2020-01-24 2021-07-29 10X Genomics, Inc. Methods for spatial analysis using proximity ligation
US12076701B2 (en) 2020-01-31 2024-09-03 10X Genomics, Inc. Capturing oligonucleotides in spatial transcriptomics
US12059674B2 (en) 2020-02-03 2024-08-13 Tecan Genomics, Inc. Reagent storage system
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US12110541B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Methods for preparing high-resolution spatial arrays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US12129516B2 (en) 2020-02-07 2024-10-29 10X Genomics, Inc. Quantitative and automated permeabilization performance evaluation for spatial transcriptomics
US12281357B1 (en) 2020-02-14 2025-04-22 10X Genomics, Inc. In situ spatial barcoding
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
ES3014967T3 (en) 2020-04-22 2025-04-28 10X Genomics Inc Methods for spatial analysis using targeted rna depletion
WO2021226581A1 (en) * 2020-05-08 2021-11-11 Baebies, Inc. Multidimensional barcode pooling
EP4414459B1 (de) 2020-05-22 2025-09-03 10X Genomics, Inc. Simultane räumlich-zeitliche messung der genexpression und der zellaktivität
EP4153776B1 (de) 2020-05-22 2025-03-05 10X Genomics, Inc. Räumliche analyse zur erkennung von sequenzvarianten
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
EP4421186B1 (de) 2020-06-08 2025-08-13 10X Genomics, Inc. Verfahren zur bestimmung eines chirurgischen randes und verfahren zur verwendung davon
WO2021252591A1 (en) 2020-06-10 2021-12-16 10X Genomics, Inc. Methods for determining a location of an analyte in a biological sample
EP4450639B1 (de) 2020-06-25 2025-10-15 10X Genomics, Inc. Räumliche analyse der dna-methylierung
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US12209280B1 (en) 2020-07-06 2025-01-28 10X Genomics, Inc. Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
EP4208543A1 (de) 2020-09-01 2023-07-12 Enza Zaden Beheer B.V. Krankheitsresistente squashpflanzen
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
US20230407366A1 (en) 2020-10-06 2023-12-21 Keygene N.V. Targeted sequence addition
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
WO2022112316A1 (en) 2020-11-24 2022-06-02 Keygene N.V. Targeted enrichment using nanopore selective sequencing
WO2022112394A1 (en) 2020-11-25 2022-06-02 Koninklijke Nederlandse Akademie Van Wetenschappen Ribosomal profiling in single cells
WO2022140028A1 (en) 2020-12-21 2022-06-30 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
WO2022207114A1 (en) 2021-04-01 2022-10-06 Enza Zaden Beheer B.V. Stay green cucurbitaceae plant
CN113130005B (zh) * 2021-04-12 2022-11-22 中国科学院东北地理与农业生态研究所 一种基于m2群体的候选因果突变位点基因定位的方法
EP4305196B1 (de) 2021-04-14 2025-04-02 10X Genomics, Inc. Verfahren zur messung der fehllokalisierung eines analyten
IL305936A (en) 2021-04-15 2023-11-01 Keygene Nv Integrated regeneration of recalcitrant plants
WO2022236054A1 (en) 2021-05-06 2022-11-10 10X Genomics, Inc. Methods for increasing resolution of spatial analysis
EP4582555A3 (de) 2021-06-03 2025-10-22 10X Genomics, Inc. Verfahren, zusammensetzungen, kits und systeme zur verbesserung der analyterfassung zur räumlichen analyse
EP4196605B1 (de) 2021-09-01 2024-12-04 10X Genomics, Inc. Verfahren zur blockierung einer erfassungssonde auf einer räumlichen anordnung
WO2023086880A1 (en) 2021-11-10 2023-05-19 10X Genomics, Inc. Methods, compositions, and kits for determining the location of an analyte in a biological sample
WO2023102118A2 (en) 2021-12-01 2023-06-08 10X Genomics, Inc. Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis
EP4482979B1 (de) 2022-11-09 2025-10-01 10X Genomics, Inc. Verfahren, zusammensetzungen und kits zur bestimmung der position mehrerer analyten in einer biologischen probe
WO2024121354A1 (en) 2022-12-08 2024-06-13 Keygene N.V. Duplex sequencing with covalently closed dna ends
JP2025542235A (ja) 2022-12-22 2025-12-25 キージーン ナムローゼ フェンノートシャップ プロトプラストカルス接木による再生
WO2024209000A1 (en) 2023-04-04 2024-10-10 Keygene N.V. Linkers for duplex sequencing
WO2025016551A1 (en) 2023-07-14 2025-01-23 Enza Zaden Beheer B.V. Stay green cucumber plant
WO2025257212A1 (en) 2024-06-11 2025-12-18 Keygene N.V. Screening and regeneration of protoplast callus

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US24939A (en) 1859-08-02 Improvement in sewing-machines
DE3465508D1 (en) 1983-04-28 1987-09-24 Flexible Steel Lacing Co Method and apparatus for riveting fasteners to a belt
JPH04504356A (ja) 1989-01-31 1992-08-06 ユニバーシティ オブ マイアミ 染色体ｄｎａの顕微解剖と増幅
CA2119557C (en) 1991-09-24 2004-02-24 Marc Zabeau Selective restriction fragment amplification: a general method for dna fingerprinting
US20100267023A1 (en) 1992-09-24 2010-10-21 Keygene N.V. Selective restriction fragment amplification: fingerprinting
WO1995019697A1 (en) 1994-01-21 1995-07-27 North Carolina State University Methods for within family selection in woody perennials using genetic markers
EG23907A (en) 1994-08-01 2007-12-30 Delta & Pine Land Co Control of plant gene expression
US6013445A (en) 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
AU704660B2 (en) 1994-11-28 1999-04-29 E.I. Du Pont De Nemours And Company Compound microsatellite primers for the detection of genetic polymorphisms
US5565340A (en) 1995-01-27 1996-10-15 Clontech Laboratories, Inc. Method for suppressing DNA fragment amplification during PCR
WO1998015644A2 (en) * 1996-09-27 1998-04-16 The Chinese University Of Hong Kong Parallel polynucleotide sequencing method
US6100030A (en) 1997-01-10 2000-08-08 Pioneer Hi-Bred International, Inc. Use of selective DNA fragment amplification products for hybridization-based genetic fingerprinting, marker assisted selection, and high-throughput screening
US6090556A (en) 1997-04-07 2000-07-18 Japan Science & Technology Corporation Method for quantitatively determining the expression of a gene
EP0981609B1 (de) 1997-05-13 2001-09-19 Azign Bioscience A/S Eine methode zum klonieren von mrna und darstellung von differentiell exprimierten transcripten (dodet)
EP0930370B1 (de) * 1997-12-15 2007-08-08 CSL Behring GmbH Markierter Primer, geeignet für die Detektion von Nukleinsäuren
CA2273616A1 (en) 1998-06-08 1999-12-08 The Board Of Trustees Of The Leland Stanford Junior University Method for parallel screening of allelic variation
US6124201A (en) 1998-06-12 2000-09-26 Advanced Micro Devices, Inc. Method for manufacturing semiconductors with self-aligning vias
ATE244771T1 (de) 1998-07-29 2003-07-15 Keygene Nv Verfahren zur erkennung von nukleinsäuremethylierungen durch aflp
US6232067B1 (en) 1998-08-17 2001-05-15 The Perkin-Elmer Corporation Adapter directed expression analysis
US6703228B1 (en) 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
EP1001037A3 (de) 1998-09-28 2003-10-01 Whitehead Institute For Biomedical Research Vorselektion und Isolierung eines Einzelnukleotidpolymorphismus
CA2345441A1 (en) 1998-10-27 2000-05-04 Affymetrix, Inc. Complexity management and analysis of genomic dna
US6480791B1 (en) 1998-10-28 2002-11-12 Michael P. Strathmann Parallel methods for genomic analysis
AU780119B2 (en) 1999-01-06 2005-03-03 Cornell Research Foundation Inc. Accelerating identification of single nucleotide polymorphisms and alignment of clones in genomic sequencing
US20040029155A1 (en) 1999-01-08 2004-02-12 Curagen Corporation Method for identifying a biomolecule
ATE247465T1 (de) 1999-01-12 2003-09-15 Quanam Medical Corp Arzneimittel und verfahren zur verabreichung von wasserunlöslichen paclitaxelderivaten
DE19911130A1 (de) 1999-03-12 2000-09-21 Hager Joerg Verfahren zur Identifikation chromosomaler Regionen und Gene
US6261782B1 (en) 1999-04-06 2001-07-17 Yale University Fixed address analysis of sequence tags
WO2000061800A2 (en) 1999-04-09 2000-10-19 Keygene N.V. Method for the analysis of aflp® reaction mixtures using primer extension techniques
US20040031072A1 (en) 1999-05-06 2004-02-12 La Rosa Thomas J. Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement
US20020119448A1 (en) 1999-06-23 2002-08-29 Joseph A. Sorge Methods of enriching for and identifying polymorphisms
US20030204075A9 (en) 1999-08-09 2003-10-30 The Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
AU7712400A (en) 1999-09-23 2001-04-24 Gene Logic, Inc. Indexing populations
US6287778B1 (en) * 1999-10-19 2001-09-11 Affymetrix, Inc. Allele detection using primer extension with sequence-coded identity tags
US6958225B2 (en) 1999-10-27 2005-10-25 Affymetrix, Inc. Complexity management of genomic DNA
WO2001038572A1 (fr) 1999-11-19 2001-05-31 Takara Bio Inc. Methode d'amplification d'acides nucleiques
AU2001253063A1 (en) 2000-03-31 2001-10-15 Fred Hutchinson Cancer Research Center Reverse genetic strategy for identifying functional mutations in genes of known sequence
US20110131679A2 (en) 2000-04-19 2011-06-02 Thomas La Rosa Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
WO2001088189A2 (en) 2000-05-15 2001-11-22 Keygene N.V. Microsatellite-aflp®
US7300751B2 (en) 2000-06-30 2007-11-27 Syngenta Participations Ag Method for identification of genetic markers
GB0016742D0 (en) * 2000-07-10 2000-08-30 Simeg Limited Diagnostic method
ATE380883T1 (de) * 2000-10-24 2007-12-15 Univ Leland Stanford Junior Direkte multiplex charakterisierung von genomischer dna
US6958217B2 (en) * 2001-01-24 2005-10-25 Genomic Expression Aps Single-stranded polynucleotide tags
US7141364B1 (en) 2001-03-29 2006-11-28 Council Of Scientific And Industrial Research Universal primers for wildlife identification
US20040053236A1 (en) * 2001-03-30 2004-03-18 Mccallum Claire M. Reverse genetic strategy for identifying functional mutations in genes of known sequences
WO2002083911A1 (en) 2001-04-12 2002-10-24 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Production of plants with increased tolerance to drought stress or with increased transpiration
JP2004524044A (ja) 2001-04-20 2004-08-12 カロリンスカ イノベイションズ アクチボラゲット 制限部位タグ付きマイクロアレイを用いたハイスループットゲノム解析方法
AU2002323509A1 (en) 2001-08-30 2003-03-18 Purdue Research Foundation Methods to produce transgenic plants resistant to osmotic stress
EP1288301A1 (de) 2001-08-31 2003-03-05 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin Resistanzgen von Pflanzen abstamend
US7504222B2 (en) 2001-10-31 2009-03-17 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
CA2498668C (en) 2002-03-27 2012-05-08 Agrinomics Llc Generation of plants with improved drought tolerance
US6815167B2 (en) 2002-04-25 2004-11-09 Geneohm Sciences Amplification of DNA to produce single-stranded product of defined sequence and length
US20070065816A1 (en) 2002-05-17 2007-03-22 Affymetrix, Inc. Methods for genotyping
US7108976B2 (en) 2002-06-17 2006-09-19 Affymetrix, Inc. Complexity management of genomic DNA by locus specific amplification
US20040086912A1 (en) 2002-06-21 2004-05-06 Shujun Luo Method for detecting foreign DNA in a host Genome
EP1546345B1 (de) 2002-09-05 2007-03-28 Plant Bioscience Limited Genomteilung
US20040157238A1 (en) * 2002-09-20 2004-08-12 Quinn John J. Method for detection of multiple nucleic acid sequence variations
WO2004035798A2 (en) 2002-10-18 2004-04-29 Cropdesign N.V. Identification of e2f target genes and uses thereof
WO2004057017A2 (en) 2002-12-18 2004-07-08 Third Wave Technologies, Inc. Detection of small nucleic acids
JP2004208586A (ja) * 2002-12-27 2004-07-29 Wakunaga Pharmaceut Co Ltd Ｈｌａの検出
ES2394881T3 (es) 2003-01-10 2013-02-06 Keygene N.V. Procedimiento basado en la AFLP para la integración de mapas físicos y genéticos
AU2004209001B2 (en) 2003-01-29 2007-10-11 454 Life Sciences Corporation Bead emulsion nucleic acid amplification
JP4691014B2 (ja) 2003-02-26 2011-06-01 カリダ ゲノミクス，インコーポレーテッド ハイブリダイゼーションによるランダムアレイｄｎａ分析
JP4888876B2 (ja) 2003-06-13 2012-02-29 田平 武 アルツハイマー病の治療のための組換えアデノ随伴ウィルスベクター
US7754945B2 (en) 2003-06-24 2010-07-13 Agrigenetics Inc. Generation of plants with improved drought tolerance
WO2005002326A2 (en) 2003-06-24 2005-01-13 Agrinomics Llc Generation of plants with improved drought tolerance
US7051935B2 (en) 2003-07-28 2006-05-30 Imageid Ltd. Color calibration for color bar codes
US7365179B2 (en) 2003-09-09 2008-04-29 Compass Genetics, Llc Multiplexed analytical platform
JP2007521798A (ja) * 2003-10-21 2007-08-09 ザ・ボルカニ・センター−ザ・ステイト・オブ・イスラエル、ミニストリイ・オブ・アグリカルチヤー、アグリカルチユラル・リサーチ・オーガニゼイシヨン トマトｈｉｇｈｐｉｇｍｅｎｔ−１突然変異表現型（ｈｐ−１及びｈｐ−１Ｗ）に関与する単離ヌクレオチド配列及びその使用
BRPI0415468A (pt) 2003-10-24 2007-03-27 Mmi Genomics Inc métodos e sistemas para inferir caracterìsticas para controlar criação não de gado
WO2005065814A1 (en) 2004-01-07 2005-07-21 Solexa Limited Modified molecular arrays
US20050233354A1 (en) 2004-01-22 2005-10-20 Affymetrix, Inc. Genotyping degraded or mitochandrial DNA samples
DE602005018166D1 (de) 2004-02-12 2010-01-21 Population Genetics Technologi Genetische analyse mittels sequenzspezifischem sortieren
US7709262B2 (en) * 2004-02-18 2010-05-04 Trustees Of Boston University Method for detecting and quantifying rare mutations/polymorphisms
EP1574585A1 (de) 2004-03-12 2005-09-14 Plant Research International B.V. Methode für die selektive Verfielfältigung von DNS-Fragmenten für genetische Fingerabdrücke
JP4809594B2 (ja) 2004-08-02 2011-11-09 東京エレクトロン株式会社 検査装置
FR2876479B1 (fr) 2004-10-11 2006-12-15 Parkeon Machine a pieces a receptacle de pieces de monnaie amovible
US7220549B2 (en) * 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
US7407757B2 (en) 2005-02-10 2008-08-05 Population Genetics Technologies Genetic analysis by sequence-specific sorting
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
US20070009925A1 (en) * 2005-05-05 2007-01-11 Applera Corporation Genomic dna sequencing methods and kits
CA2612145A1 (en) 2005-05-10 2006-11-16 Eric A. Johnson Methods of mapping polymorphisms and polymorphism microarrays
EP3257949A1 (de) 2005-06-15 2017-12-20 Complete Genomics Inc. Nukleinsäureanalyse durch zufällige mischungen von nichtüberlappenden fragmenten
CN101278058A (zh) 2005-06-23 2008-10-01 科因股份有限公司 使用高通量测序技术对复杂基因组测序的改良策略
DE602006018744D1 (de) 2005-06-23 2011-01-20 Keygene Nv Strategien mit hohem durchsatz zur identifizierung und zum nachweis von polymorphismen
US20070020640A1 (en) 2005-07-21 2007-01-25 Mccloskey Megan L Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis
US20090170713A1 (en) * 2005-09-29 2009-07-02 Keygene N.V. High throughput screening of mutagenized populations
US10316364B2 (en) 2005-09-29 2019-06-11 Keygene N.V. Method for identifying the source of an amplicon
AU2006312378B2 (en) 2005-11-14 2012-02-16 Keygene N.V. Method for high throughput screening of transposon tagging populations and massive parallel sequence identification of insertion sites
ES2558124T3 (es) 2005-12-22 2016-02-02 Keygene N.V. Procedimiento para detección de polimorfismos basada en AFLP de alto rendimiento
WO2007087312A2 (en) 2006-01-23 2007-08-02 Population Genetics Technologies Ltd. Molecular counting
ES2829295T3 (es) 2006-04-04 2021-05-31 Keygene Nv Detección de alto rendimiento de marcadores moleculares basados en AFLP y secuenciación de alto rendimiento
US8362325B2 (en) 2007-10-03 2013-01-29 Ceres, Inc. Nucleotide sequences and corresponding polypeptides conferring modulated plant characteristics
US20090124758A1 (en) 2007-11-09 2009-05-14 Bridgestone Sports Co., Ltd. Golf ball
US20140051585A1 (en) 2012-08-15 2014-02-20 Natera, Inc. Methods and compositions for reducing genetic library contamination
JP2016521557A (ja) 2013-06-07 2016-07-25 キージーン・エン・フェー 標的配列決定のための方法

Also Published As

Publication number Publication date
US20160258006A1 (en) 2016-09-08
US20170342486A1 (en) 2017-11-30
US9670542B2 (en) 2017-06-06
CA2623539C (en) 2015-12-15
US20170022560A1 (en) 2017-01-26
EP1929039A2 (de) 2008-06-11
WO2007037678A2 (en) 2007-04-05
US20170114405A1 (en) 2017-04-27
US9574230B2 (en) 2017-02-21
DE602006011486D1 (de) 2010-02-11
US20140080716A1 (en) 2014-03-20
US11649494B2 (en) 2023-05-16
US20090170713A1 (en) 2009-07-02
CA2623539A1 (en) 2007-04-05
US20120309633A1 (en) 2012-12-06
AU2006295556B2 (en) 2012-07-05
CA2910861C (en) 2018-08-07
US20170166962A1 (en) 2017-06-15
US20200291471A1 (en) 2020-09-17
EP1929039B2 (de) 2013-11-20
DK1929039T4 (en) 2014-02-17
CN101313078B (zh) 2013-04-10
US20190153534A1 (en) 2019-05-23
WO2007037678A3 (en) 2007-05-31
US9376719B2 (en) 2016-06-28
JP2009509527A (ja) 2009-03-12
JP5237099B2 (ja) 2013-07-17
US10233494B2 (en) 2019-03-19
US9657335B2 (en) 2017-05-23
EP1929039B1 (de) 2009-12-30
US10538806B2 (en) 2020-01-21
US9745627B2 (en) 2017-08-29
US8614073B2 (en) 2013-12-24
AU2006295556A1 (en) 2007-04-05
ES2338459T3 (es) 2010-05-07
US20180245151A1 (en) 2018-08-30
CN101313078A (zh) 2008-11-26
CA2910861A1 (en) 2007-04-05
US20170159120A1 (en) 2017-06-08
ES2338459T5 (es) 2014-02-24
DK1929039T3 (da) 2010-03-08

Similar Documents

Publication Publication Date Title
ATE453728T1 (de) Screening mutagenisierter populationen mit hohem durchsatz
ES2421596T3 (es) Desaminasa inducida por activación (AID)
EP1994142A4 (de) Verfahren und zusammensetzungen zur schnellen isolierung kleiner rna-moleküle
WO2007065025A3 (en) Method of dna analysis using micro/nanochannel
EP4242327A3 (de) Strichkodes mit kombinatorischer sequenz für hochdurchsatz screening
ATE470722T1 (de) Strategien zur genexpressionsanalyse
WO2007039319A3 (en) Dna microarray for rapid identification of candida albicans in blood cultures
EP3150750A3 (de) Peptidkonstrukte und testsysteme dafür
DK1907583T4 (da) Enkeltmolekyle-arrays til genetisk og kemisk analyse
UA94582C2 (ru) Генетическая модификация mon89788 сои и способы ее определения
CY1113713T1 (el) Ανοσοκατασταλτικα πολυπεπτιδια και νουκλεϊκα οξεα
WO2002018646A3 (en) Gene discovery using microarrays
TR201903963T4 (tr) Hizalama içermeyen sekans analizi kullanılarak bir hedef sekans içindeki mutasyon(lar)ı içeren üyeler için bir popülasyonun taranmasına ait yüksek verimlilik metodu.
Stasi et al. Two-hybrid-based systems: Powerful tools for investigation of membrane traffic machineries
ATE548469T1 (de) Verfahren zur identifizierung mehrerer mutationen oder methylierungsmarkern in einem dominierenden hintergrund von wildtyp-dna
WO2004027024A3 (en) Isolation of genetic molecules from a complex biological construct for use in genetic expression analysis
WO2008073378A3 (en) High throughput dna sequencing method and apparatus
WO2009102697A3 (en) Methods of obtaining antigen-specific t cell populations
UA95446C2 (ru) Мутаци в генах oas1
WO2005100611A3 (en) Detection of viral nucleic acid and method for reverse transcribing rna
EP1891240A4 (de) Verfahren zur erzeugung einer verbesserten genexpressionsanalyse und genexpressionsanalysevergleichstestergebnisse
DK1523678T3 (da) Funktionelle screeningsmetoder involverende protein-translokation/redistribution
WO2006105519A3 (en) Protein microarray system
WO2006055040A3 (en) Identification of proteins in a genome
DK1844143T3 (da) Fremgangsmåde til generering af translationelt aktive lineære DNA-molekyler og anvendelse deraf i array-format

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1929039

Country of ref document: EP