BR112019003704A2 - métodos para a detecção de alterações na cópia genômica em amostras de dna - Google Patents
métodos para a detecção de alterações na cópia genômica em amostras de dnaInfo
- Publication number
- BR112019003704A2 BR112019003704A2 BR112019003704A BR112019003704A BR112019003704A2 BR 112019003704 A2 BR112019003704 A2 BR 112019003704A2 BR 112019003704 A BR112019003704 A BR 112019003704A BR 112019003704 A BR112019003704 A BR 112019003704A BR 112019003704 A2 BR112019003704 A2 BR 112019003704A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- dna samples
- detecting
- genomic copy
- detecting genomic
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 239000012472 biological sample Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 230000007614 genetic variation Effects 0.000 abstract 1
- 230000000869 mutational effect Effects 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 230000005945 translocation Effects 0.000 abstract 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C12Q1/686—Polymerase chain reaction [PCR]
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- C12Q1/6869—Methods for sequencing
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- C12Q2523/00—Reactions characterised by treatment of reaction samples
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- C12Q2525/10—Modifications characterised by
- C12Q2525/191—Modifications characterised by incorporating an adaptor
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- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
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- C12Q2537/16—Assays for determining copy number or wherein the copy number is of special importance
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- C12Q2545/00—Reactions characterised by their quantitative nature
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- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/159—Microreactors, e.g. emulsion PCR or sequencing, droplet PCR, microcapsules, i.e. non-liquid containers with a range of different permeability's for different reaction components
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- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
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- C12Q2600/156—Polymorphic or mutational markers
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Abstract
a presente invenção inclui composições e métodos úteis para a detecção de uma alteração mutacional, snp, translocação, inversão, deleção, alteração no número de cópias ou outra variação genética dentro de uma amostra de dna genômico celular ou dna livre de células (cfdna). em algumas modalidades, as composições e métodos da presente invenção proporcionam um nível extremamente elevado de resolução que é particularmente útil na detecção de variações no número de cópias numa pequena fração do cfdna total de uma amostra biológica (por exemplo, sangue).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662379593P | 2016-08-25 | 2016-08-25 | |
US201762481538P | 2017-04-04 | 2017-04-04 | |
PCT/US2017/048434 WO2018039463A1 (en) | 2016-08-25 | 2017-08-24 | Methods for the detection of genomic copy changes in dna samples |
Publications (1)
Publication Number | Publication Date |
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BR112019003704A2 true BR112019003704A2 (pt) | 2019-05-28 |
Family
ID=61245331
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112019003704A BR112019003704A2 (pt) | 2016-08-25 | 2017-08-24 | métodos para a detecção de alterações na cópia genômica em amostras de dna |
Country Status (13)
Country | Link |
---|---|
US (2) | US11319594B2 (pt) |
EP (1) | EP3504347A4 (pt) |
JP (3) | JP7217224B2 (pt) |
KR (2) | KR20230035431A (pt) |
CN (2) | CN117286217A (pt) |
AU (2) | AU2017315769B2 (pt) |
BR (1) | BR112019003704A2 (pt) |
CA (1) | CA3034649A1 (pt) |
IL (1) | IL264971B1 (pt) |
MX (1) | MX2019002093A (pt) |
RU (1) | RU2019108294A (pt) |
SG (1) | SG11201901371XA (pt) |
WO (1) | WO2018039463A1 (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2892646A1 (en) | 2012-12-10 | 2014-06-19 | Resolution Bioscience, Inc. | Methods for targeted genomic analysis |
MX2018005858A (es) | 2015-11-11 | 2019-02-20 | Resolution Bioscience Inc | Construccion de alta eficacia de bibliotecas de adn. |
JP7217224B2 (ja) * | 2016-08-25 | 2023-02-02 | レゾリューション バイオサイエンス, インコーポレイテッド | Dna試料中のゲノムコピー変化の検出方法 |
EP3762513A1 (en) | 2018-03-08 | 2021-01-13 | St. Johns University | Circulating serum cell-free dna biomarkers and methods |
EP3856903A4 (en) | 2018-09-27 | 2022-07-27 | Grail, LLC | METHYLATION MARKER AND TARGETED METHYLATION PROBE PANEL |
CN111118610A (zh) * | 2018-10-31 | 2020-05-08 | 深圳华大基因股份有限公司 | 用于基因突变高深度测序的基因芯片及其制备方法和应用 |
AU2019372440A1 (en) * | 2018-11-02 | 2021-05-27 | The Regents Of The University Of California | Methods to diagnose and treat cancer using non-human nucleic acids |
KR102452413B1 (ko) * | 2019-08-19 | 2022-10-11 | 주식회사 지씨지놈 | 핵산 단편간 거리 정보를 이용한 염색체 이상 검출 방법 |
JP2022544626A (ja) * | 2019-08-19 | 2022-10-19 | グリーン クロス ゲノム コーポレーション | 核酸断片間距離情報を用いた染色体異常検出方法 |
KR102184277B1 (ko) * | 2020-01-16 | 2020-11-30 | 성균관대학교산학협력단 | 초음파 진단 및 dna 검사 일체형 ai 자가 건강 관리 장치 및 이를 이용한 원격 의료 진단 방법 |
US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
CN113496760B (zh) * | 2020-04-01 | 2024-01-12 | 深圳华大基因科技服务有限公司 | 基于第三代测序的多倍体基因组组装方法和装置 |
CN113113085B (zh) * | 2021-03-15 | 2022-08-19 | 杭州杰毅生物技术有限公司 | 基于智能宏基因组测序数据肿瘤检测的分析系统及方法 |
GB202108237D0 (en) * | 2021-06-09 | 2021-07-21 | Univ London | Cancer methods |
CN114649094B (zh) * | 2022-03-30 | 2022-11-15 | 广东省人民医院 | 一种基于核磁共振的乳腺癌多参数临床决策辅助装置 |
CA3230267A1 (en) | 2022-08-04 | 2024-02-08 | Nam Hoon Hur | Battery pack |
Family Cites Families (105)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5591582A (en) | 1985-07-23 | 1997-01-07 | The Board Of Rijks Universiteit Leiden | Methods for detecting activated RAS oncogenes |
US5888731A (en) | 1995-08-30 | 1999-03-30 | Visible Genetics Inc. | Method for identification of mutations using ligation of multiple oligonucleotide probes |
JP2002511767A (ja) | 1997-08-28 | 2002-04-16 | ピーイー コーポレイション(エヌワイ) | 化学切断による、核酸における変異の改良された検出 |
US6480791B1 (en) | 1998-10-28 | 2002-11-12 | Michael P. Strathmann | Parallel methods for genomic analysis |
US6812341B1 (en) | 2001-05-11 | 2004-11-02 | Ambion, Inc. | High efficiency mRNA isolation methods and compositions |
US7183052B2 (en) | 2001-07-17 | 2007-02-27 | Stratagene California | Methods for detection of a target nucleic acid using multi-subunit probes |
US7432084B2 (en) | 2001-08-31 | 2008-10-07 | Rosetta Inpharmatics Llc | Methods for preparing nucleic acid samples |
US7361821B2 (en) | 2002-09-20 | 2008-04-22 | Intel Corporation | Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (SPM) reading |
AU2003284420A1 (en) | 2002-12-11 | 2004-06-30 | Keio University | Method of constructing assigned molecule and library comprising the same and method of using the same |
TW200506052A (en) | 2003-05-07 | 2005-02-16 | Takara Bio Inc | Method of analyzing DNA region |
US7393665B2 (en) | 2005-02-10 | 2008-07-01 | Population Genetics Technologies Ltd | Methods and compositions for tagging and identifying polynucleotides |
WO2007006091A1 (en) | 2005-07-07 | 2007-01-18 | Athlomics Pty Ltd | Polynucleotide marker genes and their expression, for diagnosis of endotoxemia |
GB0522310D0 (en) | 2005-11-01 | 2005-12-07 | Solexa Ltd | Methods of preparing libraries of template polynucleotides |
US7939645B2 (en) | 2006-01-06 | 2011-05-10 | Agilent Technologies, Inc | Reaction buffer composition for nucleic acid replication with packed DNA polymerases |
US7537897B2 (en) | 2006-01-23 | 2009-05-26 | Population Genetics Technologies, Ltd. | Molecular counting |
US8383338B2 (en) | 2006-04-24 | 2013-02-26 | Roche Nimblegen, Inc. | Methods and systems for uniform enrichment of genomic regions |
US7754429B2 (en) | 2006-10-06 | 2010-07-13 | Illumina Cambridge Limited | Method for pair-wise sequencing a plurity of target polynucleotides |
US8568979B2 (en) | 2006-10-10 | 2013-10-29 | Illumina, Inc. | Compositions and methods for representational selection of nucleic acids from complex mixtures using hybridization |
US20100112590A1 (en) | 2007-07-23 | 2010-05-06 | The Chinese University Of Hong Kong | Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment |
US8067164B2 (en) | 2007-08-12 | 2011-11-29 | Integrated Dna Technologies, Inc. | Microarray system with improved sequence specificity |
US9388457B2 (en) | 2007-09-14 | 2016-07-12 | Affymetrix, Inc. | Locus specific amplification using array probes |
JP5362738B2 (ja) | 2007-12-05 | 2013-12-11 | コンプリート・ジェノミックス・インコーポレイテッド | シーケンシング反応における効率のよい塩基決定 |
WO2009091798A1 (en) | 2008-01-16 | 2009-07-23 | Helicos Biosciences Corporation | Quantitative genetic analysis |
US8202691B2 (en) | 2008-01-25 | 2012-06-19 | Illumina, Inc. | Uniform fragmentation of DNA using binding proteins |
US8383345B2 (en) | 2008-09-12 | 2013-02-26 | University Of Washington | Sequence tag directed subassembly of short sequencing reads into long sequencing reads |
US8728764B2 (en) | 2008-10-02 | 2014-05-20 | Illumina Cambridge Limited | Nucleic acid sample enrichment for sequencing applications |
WO2010068856A1 (en) | 2008-12-11 | 2010-06-17 | Trustees Of Boston University | Isolation of rna |
CN103952482A (zh) | 2009-04-02 | 2014-07-30 | 弗卢伊蒂格姆公司 | 用于对目标核酸进行条形码化的多引物扩增方法 |
US9085798B2 (en) | 2009-04-30 | 2015-07-21 | Prognosys Biosciences, Inc. | Nucleic acid constructs and methods of use |
WO2010129937A2 (en) | 2009-05-08 | 2010-11-11 | Life Technologies Corporation | Methods for detecting genetic variations in dna samples |
EP2669387B1 (en) | 2009-08-25 | 2016-07-20 | Illumina, Inc. | Methods for selecting and amplifying polynucleotides |
US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
US9315857B2 (en) | 2009-12-15 | 2016-04-19 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse label-tags |
US10388403B2 (en) | 2010-01-19 | 2019-08-20 | Verinata Health, Inc. | Analyzing copy number variation in the detection of cancer |
US10378064B1 (en) | 2010-04-16 | 2019-08-13 | Chronix Biomedical | Analyzing circulating nucleic acids to identify a biomarker representative of cancer presented by a patient population |
US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US8828688B2 (en) | 2010-05-27 | 2014-09-09 | Affymetrix, Inc. | Multiplex amplification methods |
CN103119439A (zh) | 2010-06-08 | 2013-05-22 | 纽亘技术公司 | 用于多重测序的方法和组合物 |
EP2426217A1 (en) | 2010-09-03 | 2012-03-07 | Centre National de la Recherche Scientifique (CNRS) | Analytical methods for cell free nucleic acids and applications |
US9309556B2 (en) | 2010-09-24 | 2016-04-12 | The Board Of Trustees Of The Leland Stanford Junior University | Direct capture, amplification and sequencing of target DNA using immobilized primers |
TWI719339B (zh) | 2010-11-30 | 2021-02-21 | 香港中文大學 | 與癌症有關之基因或分子變異之檢測 |
KR20140024270A (ko) | 2010-12-30 | 2014-02-28 | 파운데이션 메디신 인코포레이티드 | 종양 샘플의 다유전자 분석의 최적화 |
AU2011358564B9 (en) | 2011-02-09 | 2017-07-13 | Natera, Inc | Methods for non-invasive prenatal ploidy calling |
WO2012129363A2 (en) | 2011-03-24 | 2012-09-27 | President And Fellows Of Harvard College | Single cell nucleic acid detection and analysis |
RS63008B1 (sr) | 2011-04-12 | 2022-03-31 | Verinata Health Inc | Rešavanje frakcija genoma koristeći brojanje polimorfizma |
CN103748236B (zh) | 2011-04-15 | 2018-12-25 | 约翰·霍普金斯大学 | 安全测序系统 |
WO2013056178A2 (en) | 2011-10-14 | 2013-04-18 | Foundation Medicine, Inc. | Novel estrogen receptor mutations and uses thereof |
CN103103624B (zh) | 2011-11-15 | 2014-12-31 | 深圳华大基因科技服务有限公司 | 高通量测序文库的构建方法及其应用 |
US10227587B2 (en) | 2012-01-10 | 2019-03-12 | Berry Genomics Co., Ltd. | Method for constructing a plasma DNA sequencing library |
US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
WO2013142389A1 (en) | 2012-03-20 | 2013-09-26 | University Of Washington Through Its Center For Commercialization | Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing |
US20130288915A1 (en) | 2012-04-27 | 2013-10-31 | Htg Molecular Diagnostics, Inc. | Compositions and methods for alk molecular testing |
EP2855707B1 (en) | 2012-05-31 | 2017-07-12 | Board Of Regents, The University Of Texas System | Method for accurate sequencing of dna |
JP6433893B2 (ja) | 2012-07-03 | 2018-12-05 | インテグレイテツド・デイー・エヌ・エイ・テクノロジーズ・インコーポレイテツド | Tm増強ブロッキングオリゴヌクレオチド、ならびに標的濃縮の改善およびオフターゲット選択の低減のためのベイト |
WO2014020502A2 (en) | 2012-07-31 | 2014-02-06 | Novartis Ag | Markers associated with human double minute 2 inhibitors |
CA2880764C (en) | 2012-08-03 | 2022-08-30 | Foundation Medicine, Inc. | Human papilloma virus as predictor of cancer prognosis |
US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
DE202013012824U1 (de) | 2012-09-04 | 2020-03-10 | Guardant Health, Inc. | Systeme zum Erfassen von seltenen Mutationen und einer Kopienzahlvariation |
EP2900836B1 (en) | 2012-09-28 | 2023-05-10 | Cepheid | Two-primer pcr for microrna multiplex assay |
EP2904534B1 (en) * | 2012-10-04 | 2021-12-15 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US10482994B2 (en) | 2012-10-04 | 2019-11-19 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US20150291953A1 (en) | 2012-11-02 | 2015-10-15 | Enzymatics Inc. | Methods and kits for nucleic acid sample preparation for sequencing |
WO2014071358A2 (en) | 2012-11-05 | 2014-05-08 | Foundation Medicine, Inc. | Novel ntrk1 fusion molecules and uses thereof |
CA2892646A1 (en) | 2012-12-10 | 2014-06-19 | Resolution Bioscience, Inc. | Methods for targeted genomic analysis |
US9909186B2 (en) | 2012-12-14 | 2018-03-06 | Chronix Biomedical | Personalized biomarkers for cancer |
US11158425B2 (en) | 2013-01-05 | 2021-10-26 | Foundation Medicine, Inc. | System and method for managing genomic information |
US20160186262A1 (en) * | 2013-01-23 | 2016-06-30 | Reproductive Genetics And Technology Solutions, Llc | Compositions and methods for genetic analysis of embryos |
US10745686B2 (en) | 2013-02-08 | 2020-08-18 | Qiagen Gmbh | Method for separating DNA by size |
US20160032396A1 (en) | 2013-03-15 | 2016-02-04 | The Board Of Trustees Of The Leland Stanford Junior University | Identification and Use of Circulating Nucleic Acid Tumor Markers |
EP2971097B1 (en) | 2013-03-15 | 2018-08-01 | Verinata Health, Inc | Generating cell-free dna libraries directly from blood |
US9792403B2 (en) | 2013-05-10 | 2017-10-17 | Foundation Medicine, Inc. | Analysis of genetic variants |
US20150072344A1 (en) * | 2013-09-10 | 2015-03-12 | Imdaptive Incorporated | Barcoded Universal Marker Indicator (BUMI) Tags |
US10851414B2 (en) | 2013-10-18 | 2020-12-01 | Good Start Genetics, Inc. | Methods for determining carrier status |
EP3068883B1 (en) | 2013-11-13 | 2020-04-29 | Nugen Technologies, Inc. | Compositions and methods for identification of a duplicate sequencing read |
CN103668471B (zh) | 2013-12-19 | 2015-09-30 | 上海交通大学 | 一种构建dna高通量测序文库的方法及其配套试剂盒 |
SG11201604923XA (en) | 2013-12-28 | 2016-07-28 | Guardant Health Inc | Methods and systems for detecting genetic variants |
AU2015210705B2 (en) | 2014-01-31 | 2020-11-05 | Integrated Dna Technologies, Inc. | Improved methods for processing DNA substrates |
US10208338B2 (en) * | 2014-03-03 | 2019-02-19 | Swift Biosciences, Inc. | Enhanced adaptor ligation |
US10975371B2 (en) * | 2014-04-29 | 2021-04-13 | Illumina, Inc. | Nucleic acid sequence analysis from single cells |
US20150376700A1 (en) | 2014-06-26 | 2015-12-31 | 10X Genomics, Inc. | Analysis of nucleic acid sequences |
EP3177740B1 (en) | 2014-08-06 | 2021-01-13 | Nugen Technologies, Inc. | Digital measurements from targeted sequencing |
CN107002118B (zh) | 2014-08-22 | 2022-07-08 | 分析生物科学有限公司 | 用于无细胞dna的定量遗传分析的方法 |
US20160053301A1 (en) | 2014-08-22 | 2016-02-25 | Clearfork Bioscience, Inc. | Methods for quantitative genetic analysis of cell free dna |
CN106661636A (zh) | 2014-09-05 | 2017-05-10 | 凯杰有限公司 | 衔接子连接的扩增子的制备 |
ES2726149T3 (es) | 2014-09-12 | 2019-10-02 | Mgi Tech Co Ltd | Oligonucleótido aislado y su uso en la secuenciación de ácidos nucleicos |
EP3191628B1 (en) | 2014-09-12 | 2022-05-25 | The Board of Trustees of the Leland Stanford Junior University | Identification and use of circulating nucleic acids |
US11959141B2 (en) | 2014-12-05 | 2024-04-16 | Foundation Medicine, Inc. | Multigene analysis of tumor samples |
CN107750277B (zh) | 2014-12-12 | 2021-11-09 | 维里纳塔健康股份有限公司 | 使用无细胞dna片段大小来确定拷贝数变化 |
JP6783768B2 (ja) | 2014-12-31 | 2020-11-11 | ガーダント ヘルス, インコーポレイテッド | 疾患細胞不均一性を示す疾患の検出および処置、ならびに通信試験結果のためのシステムおよび方法 |
CN107771221B (zh) | 2015-02-10 | 2021-11-02 | 香港中文大学 | 用于癌症筛查和胎儿分析的突变检测 |
HUE064231T2 (hu) | 2015-07-23 | 2024-02-28 | Univ Hong Kong Chinese | Sejtmentes DNS fragmentációs mintázatának elemzése |
EP3359694A4 (en) | 2015-10-09 | 2019-07-17 | Guardant Health, Inc. | POPULATION-BASED TREATMENT TREATMENT USING CELL-FREE DNA |
EP3693459A1 (en) | 2015-10-10 | 2020-08-12 | Guardant Health, Inc. | Methods and applications of gene fusion detection in cell-free dna analysis |
MX2018005858A (es) | 2015-11-11 | 2019-02-20 | Resolution Bioscience Inc | Construccion de alta eficacia de bibliotecas de adn. |
US10095831B2 (en) | 2016-02-03 | 2018-10-09 | Verinata Health, Inc. | Using cell-free DNA fragment size to determine copy number variations |
JP6930992B2 (ja) | 2016-02-29 | 2021-09-01 | ファウンデーション・メディシン・インコーポレイテッド | 腫瘍変異負荷を評価するための方法及びシステム |
WO2017214557A1 (en) | 2016-06-10 | 2017-12-14 | Counsyl, Inc. | Nucleic acid sequencing adapters and uses thereof |
JP7217224B2 (ja) | 2016-08-25 | 2023-02-02 | レゾリューション バイオサイエンス, インコーポレイテッド | Dna試料中のゲノムコピー変化の検出方法 |
CA3126055A1 (en) | 2016-09-30 | 2018-04-05 | Guardant Health, Inc. | Methods for multi-resolution analysis of cell-free nucleic acids |
US9850523B1 (en) | 2016-09-30 | 2017-12-26 | Guardant Health, Inc. | Methods for multi-resolution analysis of cell-free nucleic acids |
EP4345168A2 (en) | 2016-11-17 | 2024-04-03 | LGC Clinical Diagnostics, Inc. | Methods for preparing dna reference material and controls |
US11268137B2 (en) | 2016-12-09 | 2022-03-08 | Boreal Genomics, Inc. | Linked ligation |
EP3610032B1 (en) | 2017-04-14 | 2021-03-10 | Guardant Health, Inc. | Methods of attaching adapters to sample nucleic acids |
CA3120713A1 (en) | 2018-11-21 | 2020-05-28 | Avida Biomed, Inc. | Methods for targeted nucleic acid library formation |
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