CN111630166B - 条件性-siRNA及其在治疗心肌肥大中的用途 - Google Patents

条件性-siRNA及其在治疗心肌肥大中的用途 Download PDF

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CN111630166B
CN111630166B CN201880066486.5A CN201880066486A CN111630166B CN 111630166 B CN111630166 B CN 111630166B CN 201880066486 A CN201880066486 A CN 201880066486A CN 111630166 B CN111630166 B CN 111630166B
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索姆亚·达斯
艾尼·米伦·萨尔瓦多·加里卡诺
韩四平
丽莎·谢雷尔
朱莉娅·德罗加蒂斯
罗宾·胡
萨希尔·萨加尔
威廉·A·戈达德三世
约翰·罗西
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Abstract

本文公开了可由促肥大性RNA序列激活的条件性siRNA及其用于治疗诸如心肌肥大的病症的用途。条件性siRNA以钙调磷酸酶或HDAC2作为靶向。

Description

条件性-siRNA及其在治疗心肌肥大中的用途
优先权声明
本申请要求于2017年8月10日提交的美国临时专利申请号62/543,882的优先权，其全部内容通过引用整体并入本文，如同在此完整阐述。
关于联邦资助研究的声明
本发明是在美国国家科学基金会通过研究与创新的新兴领域，用于工程创新的自组装系统集成的折叠设计(EFRI-ODISSEI)授予的资助号1332411，以及美国国立卫生研究院(NIH)授予的资助号AI029329下的政府支持而完成。政府拥有本发明的某些权利。
背景
RNA干扰(RNAi)是由siRNA双链体介导的序列特异性mRNA降解途径，是细胞免疫和发育调节的关键。研究人员已通过抑制一种特定的基因产物来利用合成的RNAi触发器进行治疗，该基因产物在疾病驱动途径中是必需的，但对于正常功能却不是必需的。
然而，考虑到疾病进展中必不可少的一些基因可能在正常细胞中具有重要功能，将其作为靶向是危险的。同时，其他上调的基因对于疾病的进展不是必需的，但可作为有效的指示物。因此，本领域需要开发有效的疗法以在多种适应症中利用该差异表达。下文所述的条件性活性siRNA复合物是研究那些适应症(例如心肌肥大)的治疗的候选物。
心力衰竭(HF)是一种慢性心脏病症，影响全球的数百万人，并被认为是美国医疗保健支出的主要开支。代偿性心肌肥大是病理性心室重构的初始标志(hallmark)之一，其特征是介导和调节心肌肥大并最终导致HF的多种基因和miRNA的上调。即使在HF治疗方面取得了重要进展，但迄今为止尚未开发出没有不良反应的心脏特异性疗法。因此，本领域需要开发一种针对HF的有效疗法。
附图简要说明
本申请包含至少一个彩色附图。在向专利商标局(the Office)提出请求并支付必要费用后，会提供带有彩色附图的本申请副本。
图1显示了根据一个实施方式的Cond-siRNA构建体的二级和三级结构的比较(来自完整的原子MD模拟)。黑色箭头表示2D和3D展示之间的对应特征。
图2是显示RNAi途径的图。
图3示出了条件性siRNA的立足点(toehold)介导的链置换(displacement)过程。在步骤I中，c-siRNA遇到具有正确激活序列(输入)的RNA转录物。在步骤II中，输入RNA结合至支点。步骤III显示了支点介导的链置换。步骤IV示出了传感器链和输入，形成与pro-siRNA分离的废弃双链体。在步骤V中，XRN1，外泌体和其他胞质RNA酶迅速降解未保护的突出端(overhang)，从而将pro-siRNA转变为有效的Dicer底物。在步骤VI中，由Dicer处理siRNA以并入RISC。支点介导的链置换的基本生物物理过程包括快速的1D随机游走：每个N^2步骤中从uS到mS。这导致了支点和双链体这两者的序列特异性。热力学稳定的化学修饰仅限于传感器链，以避免动力学陷阱(traps)。
图4：A)cond-siRNA的一般构建体设计，其中绿色传感器链设计为与信号基因mRNA反向互补，从传感器侧的支点端开始有11或12bp的缺口的红色核心链设计为与传感器和向导互补，且黄色向导链设计为与靶向基因mRNA反向互补。B)cond-siRNA模型。C)cond-siRNA的分子模拟。
图5示出了根据一个实施方式的Cond-siRNA的设计过程的概述。
图6示出了根据一个实施方式的针对mRNA的假想传感器双链体，用于检查传感器的热力学稳定性。
图7示出了根据一个实施方式的结构计算，示出了具有低内部二级结构的传感器链。
图8示出了根据一个实施方式的直方图，示出了假想的传感器双链体和正确二级结构的97％预测形成。
图9示出了根据一个实施方式的针对miRNA的假想传感器双链体，用于检查传感器的热力学稳定性。
图10示出了根据一个实施方式的RNAi靶向双链体的结构。
图11是涉及调节肥大的心脏基因程序的信号途径的示意图。
图12是描绘体内和体外筛选方法的示意图。
图13：A)NuPack生成的选定NPPB 31bp传感器链的二级结构。最小二级结构，约有40-50％的自身折叠的概率。B)结合至5′和3′核心的NPPB传感器链99％的时间有突出。
图14：A)NuPack生成的选定的MYH7 31bp传感器链的二级结构。最小二级结构，约有30％的自身折叠的概率。B)结合至5′和3′核心的NPPB传感器链97％的时间有突出。
图15：A)NuPack生成的HDAC2 25bp向导链的二级结构。结合的平衡概率表明了明显的二级结构。B)NuPack生成的HDAC2向导的二级结构结合至具有与适当的传感器链结合的5′和3′突出端的核心链。尽管向导链具有显著且牢固的二级结构，但与核心链一起放置时，向导链会100％结合至核心。
图16示出了根据某些实施方式的检测鼠ANP mRNA并以鼠钙调磷酸酶作为靶向的测试构建体。图16公开了SEQ ID NO：10为″CTUCACCACCUCUCAGTGGCAAUGCGACCAA″，SEQ IDNO：19为″AGGUGGUGAAG″，SEQ ID NO：45为″CAGGAAAAGCCAAACAACACUCG″，SEQ ID NO：48为″AUUGCCACUGAG″，以及SEQ ID NO：11为″CGAGUGUUGUUUGGCUUUUCCUGUU″。
图17示出了根据某些实施方式的检测鼠和人mir-23a-3p并以鼠钙调磷酸酶作为靶向的测试构建体。图17公开了SEQ ID NO：1为″CGAAGAACGGAAAUCCCUGGCAAUGTGAT″，SEQID NO：147为″CGAAGAACGGAAAUCCCTGGCAATGTGAU″，SEQ ID NO：41为″UCCGUUCUUCG″，SEQ IDNO：45为″CAGGAAAAGCCAAACAACACUCG″，SEQ ID NO：57为″UGCCAGGGAUU″，以及SEQ ID NO：11as″CGAGUGUUGUUUGGCUUUUCCUGUU″。
图18是描述根据本发明的方法可靶向治疗的损伤部位的示意图。
图19是一系列柱状图，描绘了在体内稳态(homeostasis)中野生型小鼠组织中差异基因表达的实验结果。
图20：低氧下NRVM中的基因表达。
图21：低氧下NRVM中的差异化miRNA表达。
图22：PE处理后NRVM中的基因表达。
图23：PE处理后，NRVM中的差异化miRNA表达。
图24：具有非缺血性(TAC)和缺血性(I/R)HF的小鼠中的基因表达。
图25：具有非缺血性(TAC)和缺血性(I/R)HF的小鼠中的miRNA表达。
图26示出了MFE结构的平衡概率。
图27示出了MFE结构的平衡概率。
图28示出了MFE结构的平衡概率。
图29示出了MFE结构的平衡概率。
图30显示了在TBE中的10％非变性PAGE凝胶上的(ANP：钙调磷酸酶)和(mir-23a-3p：钙调磷酸酶)Cond-siRNA。正确的组件在绿框中指示。
图31显示了根据某些实施方式的mir-23a-3p：钙调磷酸酶Cond-siRNA的双重荧光素酶测定的结果。
图32是根据一个实施方式的柱状图，显示了在PE刺激下NRVM细胞中针对钙调磷酸酶的RNAi活动。
图33显示了根据一个实施方式的用加扰的siRNA(阴性对照)，(ANP：钙调磷酸酶)Cond-siRNA，和市售钙调磷酸酶siRNA(阳性对照)处理时具有和不具有PE刺激的NRVM细胞的图像。
图34显示了根据一种实施方式的细胞尺寸定量的结果。
图35A显示了MI后心脏重构和左心室扩大。
图35B是显示实验结果的柱状图，其中具有任何模式的MI后LV重构的患者发生心血管(CV)死亡，MI，心力衰竭(HF)，中风，或复苏的心脏骤停的综合风险更高。
图36是流程图，伴有相应的示意图，显示了从核中的pri-miRNA处理开始的RNA干扰途径。
图37是示出MI后重构的示意图。
图38是一系列柱状图，描绘了体内稳态中野生型小鼠组织中差异化miRNA表达的实验结果。
图39是包括针对人myh7基因3′UTR的候选传感器链的表。列的缩写如下：BS是坏片段；3LN是3字母(3-Letteredness)；NBP是坏点数(Number Bad Points)；P是位置。图39按照出现顺序分别公开了SEQ ID NOs：148-233。
图40是包括针对大鼠myh7基因的3′UTR的候选传感器链的表。列的缩写如下：BS是坏片段；3LN是3字母；NBP是坏点数；P是位置。图40按照出现顺序分别公开了SEQ ID NOs：234-308。
图41是包括针对人nppa基因的3′UTR的候选传感器链的表。列的缩写如下：BS是坏片段；3LN是3字母；NBP是坏点数；P是位置。图41按照出现顺序分别公开了SEQ ID NOs：309-575。
图42是包括针对大鼠nppa基因的3′UTR的候选传感器链的表。列的缩写如下：BS是坏片段；3LN是3字母；NBP是坏点数；P是位置。图42按照出现顺序分别公开了SEQ ID NOs：576-824。
图43是包括针对人nppb基因的3′UTR的候选传感器链的表。列的缩写如下：BS是坏片段；3LN是3字母；NBP是坏点数；P是位置。图43按照出现顺序分别公开了SEQ ID NOs：825-984。
图44是包括大鼠nppb基因的3′UTR的候选传感器链的表。列的缩写如下：BS是坏片段；3LN是3字母；NBP是坏点数；P是位置。图44按照出现顺序分别公开了SEQ ID NOs：985-1233。
图45显示了根据一个实施方式的Cond-siRNA构建体的3D示意图的俯视图。
发明详述
条件性-siRNA的概述
本文描述了条件性siRNA复合物(本文中也称为Cond-siRNA，条件性RNA传感器，或RNA传感器)，其包括通过核心分子与分子传感器相关联的治疗性成分(例如，siRNA分子)。条件性siRNA复合物在正常条件下是无活性的，但在分子传感器和生物标志物相互作用后会被激活。这样的分子是合成的核糖开关分子，其允许输入基因或RNA分子针对靶向输出基因“开启”RNAi途径。
RNA-传感器分子或复合物包括彼此结合以形成具有图1和45所示的双链体结构的多链分子复合物的传感器链，向导链，和核心链。在某些实施方式中，这三条链(核心，传感器，和向导)形成两个平行的寡核苷酸双链体，以双交叉(crossover)构型连接。[14](见图1)。在一些方面，每个寡核苷酸双链体的长度足以在RNA干扰(RNAi)途径内操作(参见图2，36)。例如，双链体的长度可在约15至30个碱基对之间。在一些实施方式中，双链体的长度为15至20个碱基对，长度为20至25个碱基对，长度为25至30个碱基对。在其他实施方式中，双链体的长度为约15、16、17、18、19、20、21、22、23、24、25、25、26、27、28、29、30，或超过30个碱基对。
如图1所示的双交叉构型表示RNA传感器复合物的非活性或“关闭”状态，其中传感器双链体抑制siRNA双链体的RNAi装载，充当RNAi活性的“锁”。在关闭状态下，向导链结合核心链的第一部分(或“乘客(passenger)”片段)以形成充当pro-RNA分子的siRNA双链体。pro-RNA分子在靶细胞的RNAi途径中操作，以改变与病理性病症相关的靶基因或靶RNA分子(即“治疗性靶分子”)的表达。通过与核心链的第二部分(或“保护”片段)结合的传感器链形成第二双链体，以形成传感器双链体。在一些实施方式中，核心链具有结合传感器链的第三部分(或“保护”片段)。在某些这样的实施方式中，核心链包括乘客链(P)，该乘客链(P)在每个端部通过接头(L1，L2)连接到第一和第二保护片段(A，B)，其结构如下：
5’B-L2-P-L1-A 3’
核心链的序列由传感器链和向导链的序列决定，并可以与传感器链，向导链，或这两者完全或互补。根据本文所述的实施方式，可使用任何合适的接头，包括但不限于内部C3间隔子，C6接头，三乙二醇接头。
当与细胞中的生物标志物相互作用时，RNA-传感器复合物被激活至“开启”状态，所述生物标志物表达与siRNA双链体的向导链所靶向的病理性病症相关的表型。该激活主要归因于传感器链的设计，充当RNAi活性的激活信号。在这种情况下，可以说RNA传感器复合物检测生物标志物。
传感器链包括被设计为结合与病理性病症相关的生物标志物(即，“病理性生物标记”)的核苷酸序列。如图3所示，通过将至少一个支点片段(单链)与编码至少一部分病理性生物标志物的输入RNA链结合，启动与生物标志物的结合。在传感器链置换时，传感器链和来自从pro-siRNA分子分离的废弃双链体的输入链使得pro-siRNA能够被靶细胞的RNAi系统加工。在美国专利号9，725，715中进一步解释了本文所述的条件性-siRNA的结构和结合动力学，其内容通过引用整体并入本文。
传感器链的序列可与病理性生物标志物中存在的RNA序列完全或部分互补。在某些实施方式中，传感器链与病理性生物标志物中存在的RNA序列100％互补。其他实施方式可包括与病理性生物标志物中存在的RNA序列在很大程度上互补的传感器链，例如，传感器链与病理性生物标志物中存在的RNA序列的互补可为大于70％的互补，大于75％的互补，大于80％的互补，大于85％的互补，大于90％的互补，大于95的％的互补，大于96％的互补，大于97％的互补，大于98％的互补，或大于99％的互补。
在一些实施方式中，病理性生物标志物是形成或编码与病理性病症相关的分子的RNA序列。在一些方面，病理性生物标志物是在病理性条件下存在于靶细胞中但在正常条件下基本不存在的RNA序列。或者，病理性生物标志物是与正常条件相比在病理性条件下的靶细胞中上调的RNA序列。
向导链在3′端部附近包括Dicer切开(cleavage)位点。Dicer切开位点和向导链的3′末端之间的序列与治疗性靶分子(例如靶基因，靶mRNA或靶miRNA)中发现的核苷酸序列完全或部分互补。在这种情况下，Cond-siRNA可以说会靶向基因或RNA分子。在某些实施方式中，向导链与治疗性靶分子中发现的核苷酸序列100％互补。其他实施方式可包括与治疗性靶分子中存在的核苷酸序列在很大程度上互补的向导链，例如，向导链与治疗性靶分子中发现的核苷酸序列的互补可为大于70％的互补，大于75％的互补，大于80％的互补，大于85％的互补，大于90％的互补，大于95的％的互补，大于96％的互补，大于97％的互补，大于98％的互补，或大于99％的互补。
在体内使用寡核苷酸的挑战在于防止RNA核苷酸的核酸酶降解。传感器链中的几种化学修饰可用于克服该挑战。例如，锁核酸(LNA)包括RNA核苷酸的修饰，在2′O和4′C之间额外的桥增加RNA双链体的热稳定性，并使得对核酸酶的具有抗性。2′O-甲基修饰可赋予稳定性，增加对RNA核苷酸的结合亲和力并防止核酸酶降解。并且，对于硫代磷酸酯：通过用硫替代碱基之间的磷酸酯键中的一个非桥连氧进行修饰来减少核解(nucleolytic)降解；但是也会降低结合亲和力。
因此，在某些实施方式中，RNA-传感器复合物包括对传感器链，核心链，和/或向导链的核苷酸序列的一种或多种修饰。可使用的示例性修饰包括但不限于锁核酸(LNA)，肽核酸(PNA)，2′-O-甲基修饰，吗啉代修饰，硫代磷酸酯修饰，末端(terminal)修饰，和其他接头或骨架修饰或连接。可根据US9725715B2中描述的方法选择其他的化学修饰，其公开内容在此全部并入本文。
使用cond-siRNA传感器复合物来设计用于治疗疾病或其他病理性病症的cond-siRNA传感器复合物的方法的优势在于，它允许复合物仅在患病细胞中具有生物活性，并在健康细胞中保持关闭(OFF)状态。此外，该方法可提高患病细胞的特异性，并防止毒性传递至非意向性(unintended)的靶外目标(off-target)。进一步，该方法将来自一个基因的疾病特异性与来自第二个基因的治疗功效相结合，以创建针对特定基因表达模式的精确定制的疗法。更进一步，由于以平行构型(图4)定位的两个RNA双链体的空间位阻，该方法是有利的。传感器链抑制siRNA的RNAi装载，并且仅在患病细胞中激活后才会置换(displace)。
设计条件性siRNA复合物的方法的概况
基于对每种细胞类型，病理性条件，和/或适应症具有特异性的生物标志物和治疗靶分子来设计siRNA复合物。根据某些实施方式，如下所述，用于设计和测试每个条件性siRNA复合物的方法包括几个步骤。
图5显示了设计过程的概述。在某些实施方式中，用于设计条件性siRNA复合物的方法(“设计方法”)包括确定将充当激活输入和RNAi抑制的治疗靶标的生物标志物的步骤。该步骤可包括使用本领域已知的方法确定差异化表达(即，与正常细胞相比在患病细胞中上调或存在)的一种或多种因子。
该设计方法还包括以下步骤：生成可以充当结合传感器链的生物标志物片段的生物标志物的候选靶片段的列表(即，标靶mRNA序列或标靶miRNA序列)，然后针对各个生物标志物设计传感器链。
设计方法还包括以下步骤：通过使用本领域[15]中使用的二级结构预测工具，预估所得的传感器链-由标靶片段和传感器链产生的生物标志物双链体(传感器双链体)的热力学稳定性。
该设计方法还包括以下步骤：检查最稳定的传感器双链体与待测试其条件性siRNA复合物的动物的已知转录组(transcriptome)的结合位点的唯一性。
该设计方法还包括以下步骤：通过使用可包括但不限于标准siRNA设计工具，文献参考，或启发式规则(heuristic rules)的方案来生成向导链序列列表。
该设计方法还包括从所选的向导链序列产生Dicer底物的步骤。
该设计方法还包括生成将传感器链连接至向导链的核心链的序列的步骤。
该设计方法还包括检查传感器：向导配对不会产生不期望的相互作用。
该设计方法还包括以下步骤：选择本文所述的合适的化学修饰的模式，并任选地使用本领域[16]中使用的分子模拟方法来模拟构建体，从而模拟构建体(可选的)。
该设计方法还可包括从商业供应商(例如Qiagen，Dharmacon，或IDT)合成或购买传感器，核心，和向导链的方法，然后使用凝胶电泳组装，表征，和纯化其构建体。
该设计方法还包括以下步骤：进行初步生物学测试和构建体功能的验证，然后可选地在病理性条件的体外和体内模型中进行测试，所述病理性条件包括但不限于MI诱发的适应不良的肥大(maladaptive hypertrophy)，如下所述。
下面说明与设计所述向导，所述传感器和所述核心链有关的其他实施方式。
用于mRNA生物标志物的传感器链的设计方法
根据某些实施方式，用于设计和测试靶向mRNA生物标志物的传感器链的方法包括算法，该算法包括几个步骤，如下所述。
在某些实施方式中，一种用于设计用于mRNA生物标志物的传感器链的方法(“mRNA传感器设计方法”)包括识别每个信使RNA生物标志物的3′UTR的步骤。
mRNA传感器设计方法还包括为以上识别的每个3′UTR生成所有可能的连续31个碱基序列的步骤。
mRNA传感器设计方法还包括以下步骤：通过识别每个序列的反向互补(全部或部分)，从前一步骤获得每个序列片段的预期(prospective)传感器链序列。
mRNA传感器设计方法还包括检查每个传感器链序列的以下不期望特征的步骤：(i)三个或更多个连续的G，和(ii)四个或更多个连续的A或U碱基。
mRNA传感器设计方法还包括检查每个传感器链序列的以下期望特征的步骤：(i)高于50％的G/C碱基-这与热力学稳定性相关，(ii)“三字母(three letteredness)”，(iii)传感器链5′端的第一个碱基为C或G；以及(iv)从传感器链的3′端开始的第9个碱基是C或G。根据本文所述的实施方式，“三字母”定义为包含三个数量最多的碱基的序列的比例(例如，序列主要由A，U，C；或C，G，A；或A，U，G组成的程度)。较高的三字母得分与较低的内部二级结构相关。示例性排名表可见图39和44，对应于在此提交的附录C-H中的基因或核苷酸序列。
mRNA传感器设计方法还包括对所有可能的传感器链进行分级的步骤。特征数量最少(来自4)和得分最高(来自5)的链排名最高。
mRNA传感器设计方法还包括从最高排名的链开始使用图6所示的模式产生假想的传感器双链体的步骤。
RNA传感器设计方法还包括以下步骤：从排名最高的链开始，使用Nupack或类似的二级结构预测编码来计算以下内容：(i)传感器链的内部二级结构(期望较少的内部二级结构的量)(图7)，(ii)来自7的假想的双链体的热力学稳定性。理想情况下，在1nM的链浓度下，Nupack应预测＞90％或＞95％的成分链应形成假想的传感器双链体(图8)；以及(iii)如果传感器双链体不稳定，则可在传感器序列5′末端调节1至5个碱基以增加稳定性，代价是要降低与假定生物标志物上相应结合位点的互补性。
RNA传感器设计方法还包括根据以下参数使用NCBI BLAST筛选传感器链中的热力学稳定的双链体的步骤：(i)使用“稍有相似”搜索选项，(ii)对于传感器序列，3′末端的8个碱基(构成3′支点)与目标动物(例如人或小鼠)中已知的转录物互补的碱基应不超过5个，除了意图的生物标志物之外；以及(iii)如果不符合前两个标准，则将1中考虑的序列扩大至编码区或整个mRNA。
用于miRNA生物标志物的传感器的设计方法
根据某些实施方式，用于设计和测试靶向miRNA生物标志物的传感器链的方法包括一种算法，该算法包括几个步骤，如下所述。
在某些实施方式中，用于miRNA生物标志物的传感器链的设计方法(“miRNA传感器设计方法”)包括识别每个miRNA生物标志物的向导序列的步骤，该传感器链被设计为与各个miRNA生物标志物结合(根据一个方面，通常约21个碱基)。
miRNA传感器设计方法还包括获得miRNA向导序列的反向互补序列(全部或部分)的步骤。
miRNA传感器设计方法还包括向先前步骤的序列的5′端添加8个以上的碱基的步骤。
miRNA传感器设计方法还包括自先前步骤中得到的序列开始，使用图9中所示的模式生成假想的传感器双链体的步骤。
miRNA传感器设计方法还包括使用Nupack或类似的二级结构预测代码来计算以下项目的步骤：(i)来自先前步骤的假想双链体的热力学稳定性。理想情况下，在1nM链浓度时，Nupack应预测＞90％或＞95％的成分链(component strand)应形成假想的传感器双链体。(ii)如果传感器双链体不稳定或二级结构不正确，则确定是否可以更改或修改传感器链5′端的8个末端碱基，或链A或链B的长度，以优化热力学稳定性。
miRNA传感器设计方法还包括根据以下参数在NCBI BLAST中筛选传感器链中热力学稳定的双链体的步骤：(i)使用“稍有相似”的搜索选项，(ii)对于传感器序列，在传感器5′端添加的8个碱基除了想要的miRNA以外不应增加转录物的互补性。如果增加，则调整序列/顺序并从4重新开始。
设计针对治疗性靶分子的向导链序列的方法
根据某些实施方式，如下所述，设计针对治疗性靶基因或RNA分子(例如，mRNA或miRNA)的向导链序列的方法包括几个步骤。
在某些实施方式中，设计针对治疗靶标的向导链序列的方法(“向导链设计方法”)包括使用以下至少一种方法获得一个或多个预期的向导链序列的步骤：(i)针对意图标靶找到公开的向导链序列；(ii)在靶基因上找到已知的miRNA靶位点，或(iii)使用本领域已知的公开算法或设计工具[17，18]。
向导链设计方法还包括检查向导序列的步骤，以确保5′域(domain)(图10)处的6个碱基比3′域(图10)处的6个碱基包含更多的AU。这将提高正确的链负载的概率[19]。理想情况下，3′域应富含CG，并以CG碱基对终止。
向导链设计方法还包括将四个末端碱基添加至向导链的5′端以使双链体完整的步骤。他们应富含CG以提高热力学稳定性。
向导链设计方法还包括构建如图10所示的假想的RNAi靶向双链体的步骤。
向导链设计方法还包括以下步骤：使用Nupack或类似的标准二级结构计算工具，检查向导链所具有的弱内部二级结构以及最小的与其自身结合的趋势(在1nM链浓度时不超过10％)。根据需要调整在3中添加的碱基。
设计核心链序列并检查用以向导的成对传感器的兼容性的方法
根据某些实施方式，设计核心链序列并检查用于向导的配对传感器的兼容性的方法包括几个步骤，如下所述。
在某些实施方式中，设计针对治疗靶标的向导链序列的方法(“核心链设计方法”)包括选择传感器和向导链的合适组合的步骤，上文和工作实施例中讨论了根据本文所述的实施方式设计那些链的方法。
核心链设计方法还包括通过构建形式为5′-B-C3-P-C3 A-3′的链来构建核心链的步骤，其中A和B是来自假想的传感器双链体(图6或9)的互补链B的序列，P是来自假想的RNAi双链体(图10)的乘客链的序列，C3是C3接头。
核心链设计方法还包括使用Nupack或类似的标准二级结构计算工具检查向导链和核心链碱基配对具有以下性质的步骤：(i)1nM链浓度时，＞95％的链在正确的双链体中碱基配对，(ii)向导链双链体具有正确的构象(conformation)，具有～23个碱基对双链体，两个碱基3′向导链突出端，和10-12个碱基5′和3′核心突出端，且具有最少的二级结构，以及(iii)如果不满足上述标准，则选择新的传感器或向导配对。
用于治疗心肌肥大的条件性siRNA复合物
本文公开了一种治疗策略，其以心肌肥大(通常在心肌梗塞后产生)所涉及的分子途径作为靶向，具有最小的脱靶效果。心肌梗塞(MI)是一种心脏病发作。当血块阻塞冠状动脉而阻断血液流向心脏(一种称作心脏缺血的病症)时，可能发生MI。
处于阻塞的下游的心肌失去氧，导致肌肉细胞受伤和死亡。MI后，缺氧和组织损伤诱发左心室重构(图35A，37)。心脏再灌注导致炎症和氧化损伤。MI期间心肌细胞的损伤会引起一系列生物信号事件，导致心肌细胞体积增加并以损害心脏功能的特定方式经历增殖。这种肥大反应是由包括适应不良的再生基因程序在内的因素综合作用而引起的。在适应不良的再生期间，心脏经历变化，对患者诱发不利的病症(图35B)。受影响的心室体积增大，但心室壁变薄，并且心脏泵血的能力随时间而降低。这可能导致多种严重问题，包括心力衰竭，二次心脏病发作，或猝死。因此，该过程称为适应不良性肥大(与适应性肥大相对，适应性肥大增强心脏对诸如运动等刺激的反应)。
例如，可通过抑制钙调磷酸酶和组蛋白脱乙酰化酶2(HDAC2)的药物来缓解适应不良的心肌肥大。但是，这些药物会在非心脏组织中引起严重的副作用。因此，必须要有一种限制药物对心脏的活性的方法。
本文所述的条件性小干扰RNA(cond-siRNA)的特异性和多功能性通过劫持RNA干扰(RNAi)途径，为多种疾病和癌症提供了一类新的疗法。尽管目前针对MI后心肌肥大的治疗选择可以减轻病症的严重程度，但必须要以驱动肥大性反应的内部适应不良基因程序作为靶向。特别地，由于空间位阻，cond-siRNA(图4)的序列带有信号和标靶链，仅在存在适当的心肌肥大信号时才会激活-因此仅通过由支点介导的链置换来将疾病细胞作为靶向。
本文所述的Cond-siRNA可通过使用MI的心脏RNA生物标志物作为激活信号以针对钙调磷酸酶或HDAC2开启RNAi沉默(silencing)来实现此目的。使用这种方法，靶基因的RNAi沉默限于表达MI相关的RNA生物标志物的心肌细胞。这意味着在靶标的抑制会导致严重副作用的其他器官和组织中，RNAi活性将不会开启。一方面，本文公开了一种链置换操作的，可编程的条件性siRNA复合物，其可被肥大心肌中表达的特定mRNA和miRNA转录物激活，以通过RNAi敲除来将不相关的促-肥大性(pro-hypertrophic)途径作为靶向。
为了设计用于治疗心脏肥大的有效Cond-siRNA，可根据本文所述的实施方式使用用于测量相关基因表达的体内和/或体外筛选方法。
某些基因在病理性心肌肥大条件下被上调，其可以是候选的病理性生物标志物，以将Cond-siRNA分子向导至靶细胞群，并且可以用于置换Cond-siRNA的传感器链。例如，某些信号级联在肥大刺激条件下被激活(见图11)。例如，针对在野生型(wt)小鼠以及在多种肥大条件下的差异基因表达，筛选了在病理性心肌肥大中上调的基因和miRNA，以确定哪些基因是用作设计传感器链的靶标的合适候选物。参见以下工作实施例。
体外筛选方法可包括使用在低氧条件下培养或用苯肾上腺素处理的心肌细胞系(例如新生大鼠心室肌细胞(NRVM)，人心肌细胞(HCM))。图12A。也可使用体内方法，包括但不限于，用于缺血性心力衰竭(HF)的大鼠模型(例如，缺血/再灌注模型)，或用于非缺血性HF的大鼠模型(例如，胸主动脉收缩(TAC)模型)。参见图12B。
选择用于激活Cond-siRNA的RNA病理性生物标志物(输入信号)是设计本文所述的Cond-siRNA复合物的重要过程。使用对心肌肥大病症具有特异性的病理性RNA生物标志物进行条件性RNAi活化是为了确保RNAi活动仅在心脏组织中具有活性。理想情况下，这些生物标志物应在受MI影响的心脏组织中高度过表达，而在身体其他组织中不表达。通过比较从NRVM细胞培养物和小鼠模型(具有已知的被测mRNA和miRNA的全生物表达模式)的体外和体内实验收集的数据(参见以下工作示例)，确定至少三个mRNA和三个miRNA符合标准，包括编码心房利钠肽(ANP)，B型利钠肽(BNP)，和肌球蛋白重链β(MHCβ)的mRNA，以及编码mir-23a-3p，mir-125-5p，和mir-199b-5p的miRNA。
因此，根据本文所述的实施方式，可用于激活条件性siRNA复合物的治疗性生物标志物包括但不限于，针对受MI影响的心肌细胞的mRNA生物标志物，例如下文所述的那些。
在某些实施方式中，用于治疗心肌肥大的Cond-siRNA包括被设计成将存在于心脏细胞(例如，心肌细胞)中和/或在心脏细胞中上调的生物标志物作为靶向的传感器链。此类生物标志物可包括但不限于心房利钠肽(ANP)，B型利钠肽B(BNP)，肌球蛋白重链β(MHCβ)，mir-23a-3p，mir-125-5p，和mir-199b-5p。在一些方面中，传感器链检测编码生物标志物的mRNA或miRNA序列。并且，在某些方面，传感器链通过结合至mRNA的3′UTR来检测编码生物标志物的mRNA序列。下面讨论有关示例性生物标志物的其他信息。
ANP(nppa)信号传感器链。nppa(心房利钠肽)编码在肥大条件下过度表达的ANP蛋白，因此适合作为针对肥大的生物标志物。
BNP(nppb)信号传感器线。nppb(B型利钠肽)编码BNP蛋白，其作为心脏激素起作用，并调节钠尿(natruiresis)，利尿，血管舒张和心血管体内稳态。健康个体血流中天然存在的BNP水平低；在心室中为高水平。血流中高浓度的BNP表示心力衰竭，是肥大的生物标志物。因此，在诱发的心肌肥大病症中BNP的显著上调指示有效的传感器链基因选择。
在一些实施方式中，设计了NPPB RH SSS v2.0传感器，其中基于AU富集度，发夹(hairpin)，聚G部分(tract)和8bp支点区域在整个3′UTR中通过筛选智人mRNA来手动检查31bp序列窗口。发现了三个区域；针对与其他mRNA的匹配情况以及结合的收率％的NCBIBlast检查减少了对选传感器的选项(参见NPPB传感器结构，图13)。
MHCβ(myh7)信号传感器链。MYH7(肌球蛋白重链7)编码心脏肌球蛋白的β-重链亚基。编码的蛋白质的变化量与心肌纤维的收缩速度相关。myh7主要在心室和I型肌纤维中表达。基因突变与肥大型心肌病有关，mybh7在病理性心肌肥大中上调。在诱发的心肌肥大病症中，观察到myh7明显上调，表明myh7是另一潜在的传感器链基因选择。
在一些实施方式中，设计了myh7 RH SSS v2.0传感器，其中通过筛选整个智人mRNA，手动检查了31bp序列窗口。因为mRNA的3′UTR短且有许多聚G部分(tract)，所以筛选进入了编码区；但是它们包含二级结构。仅找到并选择了1个区域；检查了NCBI Blast是否与其他mRNA匹配(例如，参见myh7传感器结构，图14)。
在一些实施方式中，传感器链与上述任何生物标志物完全互补(即100％互补)。在一些实施方式中，传感器链与上述任何生物标志物部分互补。例如，传感器链可以与生物标志物至少70％互补，与生物标志物至少70％互补，与生物标志物至少75％互补，与生物标志物至少80％互补，与生物标志物至少85％互补，与生物标志物至少90％互补，与生物标志物至少95％互补，与生物标志物至少96％互补，与生物标志物至少97％互补，与生物标志物至少98％互补，或与生物标志物至少99％互补。
此外，传感器链与生物标志物的互补性可以与编码ANP(nppa)，BNP(nppb)，或MHCβ(myh7)的mRNA序列的任何变体的任何19-40个碱基片段匹配。
在其他实施方式中，传感器链包括下表1中的序列之一：
在某些实施方式中，用于治疗心脏肥大的Cond-siRNA包括设计成将治疗性RNAi靶标作为靶向的向导链，该治疗性RNAi靶标存在于心脏细胞(例如，心肌细胞)中和/或在心脏细胞中上调，并且在本领域中已知会改善MI后的适应不良的肥大，但其全身抑制或表达可能会导致不希望的副作用。在某些实施方式中，可用于设计Cond-siRNA的向导链的治疗性靶标包括但不限于钙调磷酸酶[7-10](或其亚基，例如，PPP3Ca，PPP3CB，PPP3CC，PPP3R1，PPP3R2)，以及HDAC2[11，12]或HDAC2[11，12]。在一些方面中，向导链与编码治疗性靶标的mRNA或miRNA序列结合。
HDAC2向导链。HDAC2(组蛋白脱乙酰化酶2)通过修饰染色质结构，在转录调控，细胞周期进程和发育途径中起着中央调节器的作用。HDAC2抑制通过涉及GSK3β的途径抑制了适应不良的再生程序，从而抑制了肥大反应。HDAC2充当关键的心脏肥大调节器和潜在的治疗性靶标。
在一些实施方式中，设计了HDAC2 RH TGS v2.1向导链，其中基于HDAC2靶向的siRNA的过往研究，从HDAC2智人mRNA中获得23个碱基对序列。在3′端增加了两个U碱基对。为了防止潜在的不适当的Dicer切开和RISC复合物负载并入，故意改变了5′端的四个碱基对以使其不与mRNA匹配。还进行了NCBI Blast检查，以检查是否与其他mRNA匹配。参见HDAC2向导链结构，图15。
钙调磷酸酶向导链。钙调磷酸酶是心肌肥大的主要促成因子(propoter)，并且已发现抑制钙调磷酸酶可减少肥大。并且，由于钙调磷酸酶一直存在于缺血细胞中，因此钙调磷酸酶是本发明的良好治疗性靶标。
在一些方面中，向导链的RNAi靶向区段(即，自3′末端起的碱基1-21)与以上讨论的任何治疗性靶标完全互补(即，100％互补)。在一些方面，向导链的RNAi靶向片段(即，自3′末端起的碱基1-21)与以上讨论的任何治疗靶标部分互补。例如，传感器链可以与生物标志物至少70％互补，与生物标志物至少70％互补，与生物标志物至少75％互补，与生物标志物至少80％互补，与生物标志物至少85％互补，与生物标志物至少90％互补，与生物标志物至少95％互补，与生物标志物至少96％互补，与生物标志物至少97％互补，与生物标志物至少98％互补，或与以上讨论的任何治疗靶标至少99％互补。在其他实施方式中，自3′末端(向导链的推定种子区域(putative seed region))起的碱基14-20与编码钙调磷酸酶(例如PPP3Ca，PPP3CB，PPP3CC，PPP3R1，PPP3R2)的亚基或HDAC2的至少一部分的mRNA序列的3′UTR具有至少90％的互补性。
在某些实施方式中，抑制适应不良的肥大的Cond-siRNA是检测下表2中的来自列表A的任何生物标志物并将列表B中的任何成员作为靶向的Cond-siRNA。
表2
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因此，根据一些实施方式，本文所述的Cond-siRNA可以具有与对应于A中列出的生物标志物的RNA转录物的序列大部分或完全互补的传感器链，以及以上文描述的方式将列表B的成员作为靶向的向导链。
在其他实施方式中，传感器链包括下表3中的序列之一：
在其他实施方式中，用于治疗心脏肥大的Cond-siRNA包括核心链，该核心链被设计为根据上述方法将传感器连接至向导链。在某些方面，核心链包括下表4中的序列之一：
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在一些实施方式中，以上核心链包括C3间隔子(spacer)接头，但也可以使用任何合适的接头。
在某些实施方式中，用于治疗心肌肥大的Cond-siRNA是一种构建体，其包括如下表5中所示的向导链，核心链，和传感器链(也参见图16-17)。
在其他实施方式中，条件性siRNA复合物可包含分别选自表1，3，和4的一条传感器链，一条向导链，和一条核心链的任何组合。显示完整复合物的条件性siRNA复合物的其他实施方式可以在附录A中找到，其随附于此。
此外，如以下示例中所述，在体内和体外的不同促(pro)-肥大条件下筛选了几种mRNA和miRNA转录物，以帮助设计cond-siRNA复合物链。
治疗方法
上述的cond-siRNA复合物可以用于治疗心肌肥大的方法。因此，在一些实施方式中，本文公开了用于治疗心肌肥大的方法，其中该方法包括向受试者施用治疗有效量的上述一种或多种与心肌肥大相关的cond-siRNA的步骤。如本文所公开，受试者可以是患有MI后心肌肥大或任何其他类型的心肌肥大的任何人或其他动物。
病症的“治疗(treating)”或“治疗(treatment)”可指预防病症，减慢(slow)病症的发作或发展速度，降低病症发展的风险，预防或延迟(delay)与病症相关的症状的发展，减轻或终止与病症相关的症状，发生病症的完全或部分消退(regression)，或其某种组合。
用于治疗心肌肥大的方法，包括施用治疗有效量的治疗性组合物。“有效量”，“治疗有效量”或“有效剂量”是在受试者中产生希望的治疗效果的组合物(例如治疗性组合物或药剂)的量，例如预防或治疗目标病症或缓解(alleviate)与病症相关的症状。精确的治疗有效量是就给定受试者的治疗功效而言将产生最有效结果的组合物的量。该量将取决于多种因素而变化，包括但不限于治疗性化合物的特征(包括活性，药代动力学，药效学，和生物利用度)，受试者的生理状况(包括年龄，性别，疾病类型和阶段，一般身体状况，对给定剂量的反应性，和药物类型)，制剂中一种或多种药学上可接受的载体的性质，以及施用途径。临床和药理学领域的技术人员将能够通过常规实验确定治疗有效量，即通过监测受试者对施用化合物的反应并相应地调整剂量。有关其他指引，请参阅《雷明顿：药学科学与实践(Remington：The Science and Practice of Pharmacy)》第21版，费域科学研究院(USIP)，Lippincott Williams&Wilkins，费域，宾夕法尼亚州，2005年。
在一些实施方式中，一种或多种cond-siRNA可以单独使用或作为治疗心肌肥大的药物组合物的一部分使用。因此，在一些实施方式中，公开了包含上述任何一种或多种与心肌肥大相关的Cond-siRNA的药物组合物。治疗性组合物还可包含一种或多种药学上可接受的载体。“药学上可接受的载体”是指参与将感兴趣的化合物从一个组织，器官，或身体的一部分携带或运输至另一组织，器官，或身体的一部分的药学上可接受的材料，组合物，或载剂。例如，载体可以是液体或固体填充剂，稀释剂，赋形剂，溶剂，或封装材料，或其某种组合。载体的每种组分必须是“药学上可接受的”，因为它必须与制剂的其他成分相容。它也必须适合与它可能遇到的任何组织，器官，或身体的一部分接触，这意味着它一定不能携带毒性，刺激性，过敏性反应，免疫原性，或任何其他远远超过其治疗性益处的并发症的风险。
本文所述的治疗性组合物可以通过任何合适的施用途径来施用。施用途径可以指本领域已知的任何给药途径，包括但不限于气雾剂，肠，鼻，眼，口，肠胃外，直肠，透皮(例如局部乳膏或软膏，贴剂)，或阴道。可以使用局部乳膏或软膏或通过透皮贴剂来完成“透皮”给药。“肠胃外”是指通常与注射有关的施用途径，包括眶下，输注，动脉内，囊内，心内，真皮内，肌内，腹膜内，肺内，脊髓内，胸骨内，鞘内，子宫内，静脉内，蛛网膜下腔，囊内，皮下，经粘膜，或经气管。在一个实施方式中，通过心内注射来施用心肌肥大相关的cond-siRNA或其治疗性组合物(图18)以确保局部递送至心脏组织。
已经参考实施方式和说明性示例描述了本发明，本领域技术人员可以理解，如所描述和示出的对本发明的修改不脱离说明书中所公开的本发明的精神和范围。给出实施方式以帮助理解本发明，但无意于并且不应解释为以任何方式限制其范围。示例不包括常规方法的详细描述。这样的方法是本领域普通技术人员众所周知的，并且在许多出版物中都有描述。此外，以上引用的所有参考文献和以下实施方式中的所有参考文献均通过引用全文并入本文，如同在本文中已充分阐述。随附提交的所有附录A-E构成完整公开的一部分。
实施例
实施例1：促肥大基因和miRNA表达筛选用于选择治疗心肌肥大的传感器候选物
筛选在病理性心脏肥大条件下被上调的基因和miRNA在多种条件下的小鼠和NRVM中的差异表达，以确定哪些分子是适合用作设计传感器链的生物标志物靶标的候选物。
体内稳态中的野生型小鼠组织中的差异基因表达。与其他组织相比，合适的病理性生物标志物候选物应在心脏中差异表达，以最大程度地减少脱靶效应。在wt小鼠的正常心脏，肝脏，肺，肾脏，骨骼肌，和大脑中测量了几种在病理性心肌肥大中被上调的基因(DDiT4L，MYH7，ANP，BNP)，以及控制其表达的转录因子(MEF2C，心肌素)。图19。还测量了几种miRNA，如图38所示。
低氧条件下NRVM中的差异基因和miRNA表达。如图20-21所示，于低氧条件下在NRVM中筛选合适的病理性生物标志物候选物(ANP，BNP，MYH7，MEF2C，心肌素，DDiT4L，和miRNA)以进行差异表达。
该实验模拟心肌梗塞(MI)期间的氧剥夺(低氧)。使用本领域技术人员已知的技术，在标准培养皿底物上培养准备了NRVM细胞[1，2]。然后将培养的NRVM细胞于37℃暴露至低氧条件(0.2％O2气氛)24小时。随后在常氧条件(95％环境空气/5％CO2)下培育12小时。
培育后，使用本领域的标准方案和试剂盒收获NRVM细胞并提取全部RNA[3]。通过定量RT-PCR并使用适合于mRNAs4和miRNA的标准方法对信使RNAs ANP，BNP，Myh7，MEF2C，心肌素，DDiT4L，和microRNAs mir-23a-3p，mir-125b-5p，mir-199b-5p，mir-208和mir-195进行了定量[5]。
结果显示在图20-21中，作为与在常氧条件下培育36小时的情况相比的暴露于低氧的NRVM细胞中存在的mRNA或miRNA的拷贝数的倍数变化。
该实验的结果表明，在低氧条件下，ANP，BNP，DDiT4L，mir-23a-3p，和mir-199b-5p被过量表达了4倍以上。
苯肾上腺素处理后NRVM中的差异基因和miRNA表达。与未处理的NRVM相比，苯肾上腺素(PE)处理后测得了miRNA的表达，以及ANP，BNP，MYH7，MEF2C，心肌素，DDiT4L的表达。
苯肾上腺素刺激是研究心肌细胞肥大的标准方法[6，7]。在该实验中，通过标准方案准备了NRVM细胞。然后将苯肾上腺素以50μM的浓度添加到培养基中24小时。24小时后，如上所述收获细胞用于RNA分离和分析。
实验结果表明，PE刺激后，ANP，BNP，Myh7，心肌蛋白mRNA过表达超过10倍(图22)，并且在PE刺激后，miRNA，mir-23a-3p，mir-125b-5p，和mir-199b-5p过表达超过4倍(图23)。
心力衰竭小鼠模型中的差异基因表达。在胸主动脉收缩(TAC)模型中的非缺血性心力衰竭小鼠和缺血/再灌注(I/R)缺血性心力衰竭的小鼠心脏组织中测量ANP，BNP，MYH7，MEF2C，心肌素，DDiT4L的表达，与假治疗小鼠进行比较。
在与局部缺血/再灌注(I/R)模型有关的实验中，小鼠经历了模拟局部缺血(剥夺血流)心力衰竭的程序。在第0天，通过外科手术将冠状动脉夹紧20分钟，然后再灌注，使小鼠遭受缺血性心力衰竭。28天后，处死实验小鼠。收获心脏组织，并使用如上所述的标准方案分离RNA。如上所述，使用RT-PCR对mRNA和miRNA进行定量。将处理过的小鼠中的mRNA和miRNA与对照小鼠中发现的mRNA和miRNA进行了比较，所述对照小鼠接受了不涉及夹紧冠状动脉以诱发局部缺血/再灌注的假手术(sham procedure)。
结果显示，在患有缺血性HF的小鼠中，所有测试的mRNA均过表达超过10倍(图24)。ANP和myh7的过表达超过1000倍(图24)。对于miRNA，只有mir-23a-3p显著过表达了～15倍(图25)。
在与非缺血性HF模型(TAC)有关的实验中，小鼠经历胸主动脉收缩(TAC)程序以诱发非缺血性心力衰竭。简而言之，小鼠的上胸部收缩以减少通过主动脉的血流28天。这诱发了非缺血性心力衰竭。28天后，处死动物并收获心脏组织。如上所述，使用标准方案分离RNA。如上所述，使用RT-PCR对mRNA和miRNA进行定量。将治疗过的小鼠中的mRNA和miRNA与对照小鼠中发现的mRNA和miRNA进行了比较，对照小鼠均接受了不涉及主动脉收缩的假手术。
结果显示，在收缩的小鼠中，所有测试的mRNA都过表达超过20倍(图24)。ANP和myh7过表达超过1000倍(图24)。对于miRNA，所有测试的miRNA均过表达超过10倍(图25)。而且，mir-23a-3p过表达了～80倍(图25)。
实施例2：ANP的设计：钙调磷酸酶Cond-siRNA
信使RNA的5′UTR和编码序列经常被mRNA结合蛋白或转运核糖体占据。在哺乳动物中，miRNA通常在3′UTR位点结合以调节mRNA。因此，3′UTR中的结合位点可能比5′UTR中的位点和mRNA区域的编码序列更易接近(accessible)。
当设计用于检测mRNA的传感器时，希望的是从3′UTR中的位点开始。如果找不到此类位点或有其他原因(例如需要在编码区或5′UTR中检测特定的重要序列)，则可以针对这些位点设计传感器。
ANP 3’UTR测序结果。鼠模型用于测试ANP的能力：钙调磷酸酶Cond-siRNAs抑制苯肾上腺素诱发的心肌细胞肥大的能力。因此，将ANP传感器设计为将大鼠ANP作为靶向。
为了设计ANP传感器，对新生大鼠心室心肌细胞中发现的ANP mRNA的3′UTR进行测序，其中使用标准程序提取RNA，通过RT-PCR扩增3′UTR，并提交扩增的DNA以通过麻省总医院的DNA测序核心进行测序。
测序的DNA如下(N表示未确定的碱基)
来自CCIB DNA核心的(MGH)ANP 3’UTR测序结果＞293387-293389_D10_1_074_nppa_3_UTR_Ane.seq
＞此为正向序列：
使用NCBI BLAST，确定了中心序列
与褐家鼠nppa mRNA 3’UTR同源性为99％，与小家鼠nppa mRNA 3’UTR同源性为92％。
生成传感器候选物：
为了产生候选传感器链，确定了上述序列的反向互补。
然后，使用Python脚本生成中央粗体序列(rat nppa 3 prime utr sensor.xlsx)的所有可能的连续31nt片段(支点8nt，加双链体区域23nt)。这些是该区域的初始可能的传感器序列(T需要转换为U)。Python脚本作为附录B随附于此。
所生成的Python编码是在对每个传感器序列进行分析之后执行的：(i)针对三个或更多连续Gs(例如：GGG，GGGG，GGGGG)的每次出现添加一个扣分；(ii)针对四个或更多连续A/T(例如ATAT，AAAA，TTTT，TTAT等)的每次出现添加一个扣分；(iii)计算由G或C组成的序列的百分比；(iv)计算最多的三个碱基(例如，在A，G，C，T中，如果A，G和T在序列中最多，则碱基中A，G或T的百分比为多少)占序列的百分比。
然后，按照重要程度，通过以下标准对可能的传感器列表进行排序：(i)扣分数量最少，优选0′(ii)最高3个字母；以及(iii)最高的GC含量(例如，参见图41-42)。
针对两项质量逐一筛选排序列表上的序列：(i)根据标准RNA二级结构预测编码，假想的传感器双链体具有高稳定性和准确性；(ii)除了大鼠和小鼠中的从支点区域(3′处的8个碱基)延伸入超过50％的双链体区域(从3′起的碱基9至31′)的nppa mRNA以外，传感器链与RNA转录物几乎没有明显匹配。
确定以下传感器序列是有利的：
为了进一步提高传感器的热力学稳定性，将第一个碱基在5′处从A更改为C。这形成了以下传感器序列：
传感器(突变碱基有下划线)：CUUCACCACCU CUCAGUGGCAAUGCGACCAA(SEQ ID NO：31)
在nupack上，由该序列构造的假想传感器双链体显示出8的热力学稳定性，平衡浓度为0.97nM。另请参见图26。
使用“稍有相似”设置的传感器序列的NCBI BLAST显示除了与小鼠和大鼠ANP(nppa)mRNA之外，没有明显的序列匹配。
钙调磷酸酶是由三种催化同工酶(PPP3CA，PPP3CB，PPP3CC)之一和两个调节亚基(PPP3R1和PPP3R2)之一组成的异二聚体。为了将钙调磷酸酶作为靶向，识别了针对钙调磷酸酶的PPP3CA亚基的向导序列，其将人，大鼠，和小鼠中存在的广泛保有的靶位点：UGUUGUUUGGCUU UUCCUG UU(SEQ ID NO：32)作为靶向。
然后将片段CGAG添加至5′端以产生23nt向导链，接着根据前述规则生成核心链。这些序列如下所示：
向导：CG AG UGUUGU UUGGC UU UUCCUG UU(SEQ ID NO：11)
传感器(突变碱基有下划线)：CUUCACCACCU CUCAGUGGCAAUGCGACCAA(SEQ ID NO：33)
核心：AGGUGGUGAAG-接头-CAGGAAAAGCCAAACAACACUCG-接头-AUUGCCACUGAG(SEQID NOs：19，45&48)
如Nupack所预测，向导链加上核心链显示出良好的热力学稳定性(图27)。
然后，根据此前在美国专利号9，725，715中公开的方案添加化学修饰，其主题通过引用并入本文。最终序列如下所示：
传感器：
/5Sp9/mC*+T*mU*mC*+A*mC*mC*+A*mC*+C*mU*mC*mU*+C*mA*mG*+T*mG*+G*mC*mA*+A*mU*mG*mC*+G*mA*mC*mC*+A*mA*/3AmMO/(SEQ ID NO：34)
向导：/5AmMC6/+C*+G rArG rUrGrUrUrGrU rUrUrGrGrC rUrU rUrUrCrCrUrGrUrU(SEQ ID NO：35)
核心：mArGmGrUrGrGrUrGrArArG/iSpC3/mC*+A*
mGrGrArArArArGrCrCrArArArCrArArCrArCrUrC*mG/iSpC3/
rArUrUrGrCrCrArCrUrGrAmG(SEQ ID NOs：36，54&55)
核苷酸和修饰如下所示：(1)+A，+T，+C，+G为LNA；(2)mA，mU，mC，mG为2’-O-甲基；(3)rA，rU，rC，rG为RNA；(3)*表示硫代磷酸酯骨架连接；(4)/5Sp9/为三乙二醇接头；(5)/iSpC3/为内部C3间隔子；(6)/5AmMC6/为C6接头上的5’伯胺修饰；(7)/3AmMO/为3’伯胺修饰。
实施例3：mir-23a-3p的设计：钙调磷酸酶Cond-siRNA
mir-23a-3p传感器如下设计。miRbase的mir-23a条目可在以下URL中找到：http://www.mirbase.org/cgi-bin/mirna_entry.pl？acc＝MI0000079
mir-23a-3P序列的序列，5’-3’为：
＞hsa-miR-23a-3p MIMAT0000078
mir-23a-3p的反向互补序列为GGAAAUCCCUGGCAAUGUGAU(SEQ ID NO：38)
感测microRNA输入的Cond-siRNA传感器是microRNA向导链通常仅为21nt长，而Cond-siRNA传感器的双链体区域通常为23个核苷酸长，且支点通常为5至8个核苷酸长。这意味着microRNA向导链的长度不足以完全将传感器链从核心链上置换出来。
通过配置传感器链使向导链将传感器从与核心链的3′突出端和核心链的5′突出端的5′末端处的最后几个碱基配对置换出来，从而解决了该问题。
这样，核心链的3′突出端变得不受保护并降解。5′突出端的5′末端也变得不受保护并经历降解，最终导致整个5′突出端降解。然后，这使得传感器链从RNAi区域完全解离。
因此，假定一条21nt miRNA向导链，从3′端开始的传感器链的一些可能的几何结构，示于下表6：
在表6中，方案A给出了23bp的传感器双链体，并允许miRNA置换5′核心链片段的多达4个末端碱基，方案B，23bp传感器，置换了3个末端碱基，方案C，23bp传感器，置换了4个末端碱基，方案D，23bp传感器，置换了5个末端碱基，方案E，22bp传感器，置换了5个末端碱基，以及方案F，22bp传感器，置换了3个末端碱基。
钙调磷酸酶传感器设计：
来自表6的方案F用于设计以下钙调磷酸酶传感器：
序列：CGAAGAAC(SEQ ID NO：40)被添加至传感器的5’。设计此序列以提高传感器双链体的热力学稳定性，最小化传感器链中的二级结构，以及最小化与非-mir23a-3p转录物的重叠。
根据NCBI BLAST，传感器与人RNA转录物没有明显的非意图匹配，并且与小鼠RNA转录物仅有少量的明显的非意图匹配。
使用上述针对ANP：钙调磷酸酶构建体识别的同一钙调磷酸酶PPP3CA siRNA向导，并且使用本文所述的算法生成核心链序列。
核心：UCCGUUCUUCG-接头-CAGGAAAAGCCAAACAACACUCG-接头-UGCCAGGGAUU(SEQ IDNOS：41，45&57)
如假想的传感器双链体(图29)那样，向导链和核心链显示出良好的热力学稳定性，如Nupack所预测(图28)。
因此，最终的完全修饰序列如下：
钙调磷酸酶向导：C6胺+C*+G rArG rUrGrUrUrGrU rUrUrGrGrC rUrUrUrUrCrCrUrG rUrU(SEO ID NO：42)
Mir-23a-3p传感器，使用22bp传感器双链体并具有LNA模式：
/5Sp9/mC*+G*mA*+A*mG*mA+A*mC*+G*mG*mA*
+A*mA*mU*mC*mC*+C*mU*mG*+G*mC*mA*+A*mU*mG*+T*mG*+A*+T*/3AmMO/(SEQ IDNO：43)
核心链：mUrCrCrGrUrUrCrUrUrCrG/iSpC3/
mC*+A*mGrGrArArArArGrCrCrArArArCrArArCrArCrUrC*mG/iSpC3/
rUrGrCrCrArGrGrG mA rU mU(SEQ ID NOS：44，54&56)
核苷酸和修饰如下：(1)+A，+T，+C，+G为LNA；(2)mA，mU，mC，mG为2’-O-甲基；(3)rA，rU，rC，rG为RNA；(3)*表示硫代磷酸酯骨架连接；(4)/5Sp9/是三乙二醇接头；(5)/iSpC3/为内部C3间隔子；(6)/5AmMC6/为C6接头上的5’伯胺修饰；(7)/3AmMO/为3’伯胺修饰。
实施例4：Cond-siRNA构建体的合成和测试
为了证明Cond-siRNA在抑制心肌细胞肥大中的用途，设计并合成了Cond-siRNA以检测鼠ANP或mir-23a-3p并抑制钙调磷酸酶。该构建体示于图16和17。所有的链均购自市售寡核苷酸供应商(Exiqon Inc，现为Qiagen的一部分)。
组装和纯化。传感器，核心，和向导链在50nM至1uM链浓度下以1.0：1.1：1.0的比例混合，并在1x PBS缓冲液中进行热退火(80℃30秒，然后于50℃至60℃恒温培育～1小时，接着冷却至室温)。
当需要纯化时，将构建体以500nM退火，每孔装载20uL，在10％非变性PAGE中。在120V的1xTBE缓冲液中运行90分钟。正确的带被切除。然后使用标准RNA分离试剂盒通过粉碎和浸泡方法提取Cond-siRNA构建体。
图30显示了其中的Cond-siRNA被组装和纯化的示例性凝胶。
mir-23a-3p：钙调磷酸酶Cond-siRNA的双重荧光素酶测定(图31)。对于该测定，评估了上述Cond-siRNA在没有正确的生物标志物的情况下保持RNAi无(OFF)活性并在存在携带mir-23a-3p序列的RNA转录物的情况下将RNAi切换为有(ON)的能力。对于该测试，将未纯化的mir-23a-3p：钙调磷酸酶Cond-siRNA以指定的浓度沿着活化剂和双重荧光素酶质粒共转染到人Hek293细胞中。
活化剂质粒表达无效的转录物，具有不正确的活化剂的转录物，21碱基的mir-23a-3p序列，或与整个传感器链互补的更长的序列。
双重萤光素酶质粒编码的萤火虫萤光素酶作为对照，并以在3′UTR中具有钙调磷酸酶靶位点的海肾萤光素酶作为RNAi的靶标。
结果表明，当表达mir-23a-3p序列或完全匹配的序列时，该Cond-siRNA具有明显增加的针对钙调磷酸酶靶标的RNAi活性。图31。因此，在mir-23a-3p存在的情况下，该构建体应能够激活针对钙调磷酸酶的RNAi活性。
PE刺激下NRVM细胞中纯化的ANP：钙调磷酸酶Cond-siRNA的体外实验。在此实验中，测试了鼠ANP：钙调磷酸酶Cond-siRNA是否可以检测苯肾上腺素(PE)刺激时ANP的过表达，并激活针对钙调磷酸酶的RNAi敲除。
测试了ANP：钙调磷酸酶对鼠生物标志物和靶标的生物学作用，因为没有合适的人类模型可以测试。这种面向鼠的Cond-siRNA的生物学作用应代表针对人类配置的Cond-siRNA会具有的生物学作用。
对于该实验，在正常条件下(95％空气，5％CO2，37℃)使用标准方案培育NRVM细胞。使用RNAiMax将纯化的ANP：钙调磷酸酶Cond-siRNA以20nM浓度转染到NRVM细胞中。将转染的细胞培育24小时。然后将PE添加到培养基中，使最终浓度达到50μM。再过48小时后，收获细胞并染色或加工以分离RNA。
钙调磷酸酶mRNA的RT-PCR定量结果显示在图32中。对于每个群组(未处理和PE处理的细胞)，在具有加扰的siRNA转染的细胞(阴性对照)中观察到的钙调磷酸酶mRNA水平被标准化为1.0。在未经处理的群组中，用ANP：钙调磷酸酶Cond-siRNA转染的细胞没有可检测的钙调磷酸酶的敲除。这意味着，正如所意图的，Cond-siRNA在正常细胞中的RNAi活性极低。
在用PE处理的细胞中，Cond-siRNA激活了RNAi，而钙调磷酸酶mRNA的水平与用加扰的siRNA对照转染的细胞中观察到的水平相比降低了～50％。这表明ANP：钙调磷酸酶Cond-siRNA可以检测ANP mRNA的过表达，并按意图随钙调磷酸酶的RNAi抑制作出反应。
处理过的和未处理过的细胞的荧光显微镜成像的结果显示在图33中。结果显示，用纯化的ANP：钙调磷酸酶Cond-siRNA处理的细胞经历的肥大程度少于用加扰的siRNA处理的细胞。此外，Cond-siRNA的治疗效果与阳性对照(市售，非条件性钙调磷酸酶siRNA)类似。
使用荧光显微镜进行细胞大小定量的结果显示在图34中所示。结果显示，PE刺激导致用阴性对照加扰siRNA处理的细胞中平均细胞大小从～750μm2增加到～1300μm2。但是，在用Cond-siRNA处理的细胞中，平均细胞大小从～750μm2增加到～900μm2，并且在统计学上不显著。该结果类似于非条件性的市售钙调磷酸酶siRNA。
以上结果表明，ANP：钙调磷酸酶Cond-siRNA具有低背景RNAi活性，可以检测并响应NRVM细胞的PE刺激，并且对减少NRVM细胞的肥大具有显著的生物学作用。
实施例5：示例性向导和传感器链序列
下面是从向导链和传感器链序列自动生成核心链序列的示例。它们具有23bp的双链体，具有8个碱基支点。
实施例5a，与随机选择的人NPPA传感器配对的随机选择的人/大鼠PPP3CA mRNA向导
Cond-siRNA向导：CCAC UUUACCAGCAUCUCAGUCAUU(SEQ ID NO：58)
Cond-siRNA传感器：
核心为：CUCGCCUCUCC UGACUGAGAUGCUGGUAAAGUGGGAUGGUGACUUC(SEQ ID NO：60)
实施例5b，与随机选择的NPPB传感器配对的上述人/大鼠PPP3CA mRNA向导
Cond-siRNA向导：CCAC UUUACCAGCAUCUCAGUCAUU(SEQ ID NO：61)
Cond-siRNA传感器：
核心为：CUUCUGAUUCC UGACUGAGAUGCUGGUAAAGUGGUGCAGACACCUG(SEQ ID NO：63)
实施例5c，与随机选择的人Myh7传感器配对的上述人/大鼠PPP3CAmRNA向导
Cond-siRNA向导：CCAC UUUACCAGCAUCUCAGUCAUU(SEQ ID NO：64)
Cond-siRNA传感器：
核心为：CAGCUCCUUGG UGACUGAGAUGCUGGUAAAGUGGGAGCCUGUGUAA(SEQ ID NO：66)
实施例5d，与来自实施例1的人NPPA传感器配对的随机选择的人/大鼠HDAC2mRNA向导
Cond-siRNA向导：CCAC UUCAUCACAAGCUAUCCGCUU(SEQ ID NO：67)
Cond-siRNA传感器：
核心为：CUCGCCUCUCC GCGGAUAGCUUGUGAUGAAGUGGGAUGGUGACUUC(SEQ ID NO：69)
实施例5e，与来自实施例2的人NPPB传感器配对的上述随机选择的人/大鼠HDAC2mRNA向导
Cond-siRNA向导：CCAC UUCAUCACAAGCUAUCCGCUU(SEQ ID NO：70)
Cond-siRNA传感器：
核心为：CUUCUGAUUCC GCGGAUAGCUUGUGAUGAAGUGG UGCAGACACCUG(SEQ ID NO：72)
实施例5f，与来自实施例3的人Myh7传感器配对的上述随机选择的人/大鼠HDAC2mRNA向导
Cond-siRNA向导：CCAC UUCAUCACAAGCUAUCCGCUU(SEQ ID NO：73)
Cond-siRNA传感器：
核心为：CAGCUCCUUGG GCGGAUAGCUUGUGAUGAAGUGG GAGCCUGUGUAA(SEQ ID NO：75)
在下一个实施例中，我们再次使用实施例1-6中的向导，但选择miRNA传感器。传感器配置为22bp的双链体，具有7个碱基的突出端和对称的11个碱基的核心链突出端。
实施例5g，与mir-23a-3p传感器配对的随机选择的人/大鼠PPP3CA mRNA向导
Cond-siRNA向导：CCAC UUUACCAGCAUCUCAGUCAUU(SEQ ID NO：76)
Cond-siRNA传感器：CGAAGAAC GGAAAUCCCUGGCAAUGUGAU(SEQ ID NO：77)
核心为：UCCGUUCUUCG UGACUGAGAUGCUGGUAAAGUGG UGCCAGGGAUU(SEQ ID NO：78)
实施例5h，与mir-125b-5p传感器配对的上述人/大鼠PPP3CA mRNA向导Cond-siRNA向导：CCAC UUUACCAGCAUCUCAGUCAUU(SEQ ID NO：79)
Cond-siRNA传感器：CGACAGU UCACAAGUUAGGGUCUCAGGGA(SEQ ID NO：80)
核心为：GUGAACUGUCG UGACUGAGAUGCUGGUAAAGUGGGACCCUAACUU(SEQ ID NO：81)
实施例5i，与mir-195b-5p配对的上述人/大鼠PPP3CA mRNA向导
Cond-siRNA向导：CCAC UUUACCAGCAUCUCAGUCAUU(SEQ ID NO：82)
Cond-siRNA传感器：CCUGAA GAACAGAUAGUCUAAACACUGGG(SEQ ID NO：83)
核心为：UGUUCUUCAGG UGACUGAGAUGCUGGUAAAGUGGUUUAGACUAUC(SEQ ID NO：84)
实施例5j，与mir-23a-3p传感器配对的随机选择的人/大鼠HDAC2 mRNA向导
Cond-siRNA向导：CCAC UUCAUCACAAGCUAUCCGCUU(SEQ ID NO：85)
Cond-siRNA传感器：CGAAGAAC GGAAAUCCCUGGCAAUGUGAU(SEQ ID NO：86)
核心为：AACAGCUCCUUGG GCGGAUAGCUUGUGAUGAAGUGGGGAGCCUGUGU(SEQ ID NO：87)
实施例5k，与mir-125b-5p配对的上述随机选择的人/大鼠HDAC2 mRNA向导
Cond-siRNA向导：CCAC UUCAUCACAAGCUAUCCGCUU(SEQ ID NO：88)
Cond-siRNA传感器：CGACAGU UCACAAGUUAGGGUCUCAGGGA(SEQ ID NO：89)
核心为：UCCGUUCUUCG GCGGAUAGCUUGUGAUGAAGUGGUGCCAGGGAUU(SEQ ID NO：90)
实施例51，与mir-195b-5p传感器配对的上述随机选择的人/大鼠HDAC2mRNA向导
Cond-siRNA向导：CCAC UUCAUCACAAGCUAUCCGCUU(SEQ ID NO：91)
Cond-siRNA传感器：CCUGAA GAACAGAUAGUCUAAACACUGGG(SEQ ID NO：92)
核心为：UGUUCUUCAGG GCGGAUAGCUUGUGAUGAAGUGGUUUAGACUAUC(SEQ ID NO：93)
实施例6：由商业siRNA自动化设计网站设计的示例性siRNA
来自http://dharmacon.horizondiscovery.com/design-center/
对于以下每个类别，设计工具的任务是设计将人和大鼠mRNA这两者的蛋白质编码区作为靶向的siRNA。示出了前三名的候选。通过在反义链的5′端添加4G/C富集的碱基来制备Cond-siRNA向导。
将人(NM_000944)和大鼠(NM_017041)PPP3CA mRNA这两者作为靶向的候选siRNA向导链序列(反义，antisense)和相应的靶标位点(正义，sense)
正义：5′G.A.A.C.A.A.G.A.U.C.C.G.A.G.C.A.A.U.A.U.U 3′(SEQ ID NO：94)
反义：5′U.A.U.U.G.C.U.C.G.G.A.U.C.U.U.G.U.U.C.U.U3′(SEQ ID NO：95)
Cond-siRNA向导：5′CGAC
U.A.U.U.G.C.U.C.G.G.A.U.C.U.U.G.U.U.C.U.U 3′(SEQ ID NO：96)
正义：5′U.G.A.C.U.G.A.G.A.U.G.C.U.G.G.U.A.A.A.U.U3′(SEQ ID NO：97)
反义：5′U.U.U.A.C.C.A.G.C.A.U.C.U.C.A.G.U.C.A.U.U 3′(SEQ ID NO：98)
Cond-siRNA向导：5′CGAC
U.U.U.A.C.C.A.G.C.A.U.C.U.C.A.G.U.C.A.U.U 3′(SEQ ID NO：99)
正义：5′G.G.U.C.A.G.A.A.G.A.A.G.A.U.G.G.A.U.U.U.U 3′(SEQ ID NO：100)
反义：5′A.A.U.C.C.A.U.C.U.U.C.U.U.C.U.G.A.C.C.U.U 3′(SEQ ID NO：101)
Cond-siRNA向导：5′CCAC
A.A.U.C.C.A.U.C.U.U.C.U.U.C.U.G.A.C.C.U.U 3′(SEQ ID NO：102)
将人(NM_001142353)和大鼠(NM_017042)PPP3CB mRNA这两者作为靶向的候选siRNA向导链序列(反义)和相应的靶位点(正义)
正义：5′G.C.U.A.U.A.G.A.A.U.G.U.A.C.A.G.A.A.A.U.U3′(SEQ ID NO：103)
反义：5′U.U.U.C.U.G.U.A.C.A.U.U.C.U.A.U.A.G.C.U.U 3′(SEQ ID NO：104)
Cond-siRNA向导：5′CGAC
U.U.U.C.U.G.U.A.C.A.U.U.C.U.A.U.A.G.C.U.U(SEQ ID NO：105)
正义：5′C.C.U.U.U.A.A.G.C.A.G.G.A.A.U.G.U.A.A.U.U 3′(SEQ ID NO：106)
反义：5′U.U.A.C.A.U.U.C.C.U.G.C.U.U.A.A.A.G.G.U.U 3′(SEQ ID NO：107)
Cond-siRNA向导：5′GGAC
U.U.A.C.A.U.U.C.C.U.G.C.U.U.A.A.A.G.G.U.U(SEQ ID NO：108)
正义：5′G.C.A.A.U.U.G.G.C.A.A.G.A.U.G.G.C.A.A.U.U 3′(SEQ ID NO：109)
反义：5′U.U.G.C.C.A.U.C.U.U.G.C.C.A.A.U.U.G.C.U.U 3′(SEQ ID NO：110)
Cond-向导：5′CCAC
U.U.G.C.C.A.U.C.U.U.G.C.C.A.A.U.U.G.C.U.U(SEQ ID NO：111)
将人(NM_001243974)和大鼠(NM_134367)PPP3CB mRNA这两者作为靶向的候选siRNA向导链序列(反义)和相应的靶标位点(正义)
正义：5′G.U.A.U.A.G.A.G.U.G.U.G.U.G.C.U.G.U.A.U.U3′(SEQ ID NO：112)
反义：5′U.A.C.A.G.C.A.C.A.C.A.C.U.C.U.A.U.A.C.U.U 3’(SEQ ID NO：113)
Cond-siRNA向导：5′CCAC
U.A.C.A.G.C.A.C.A.C.A.C.U.C.U.A.U.A.C.U.U3’(SEQ ID NO：114)
正义：5′A.G.U.A.U.U.U.G.A.G.A.A.U.G.G.G.A.A.A.U.U3′(SEQ ID NO：115)
反义：5′U.U.U.C.C.C.A.U.U.C.U.C.A.A.A.U.A.C.U.U.U3′(SEQ ID NO：116)
Cond-siRNA向导：5′CCAC
U.U.U.C.C.C.A.U.U.C.U.C.A.A.A.U.A.C.U.U.U 3′(SEQ ID NO：117)
正义：5′C.U.A.U.G.U.G.G.A.C.A.G.A.G.G.C.U.A.U.U.U 3′(SEQ ID NO：118)
反义：5′A.U.A.G.C.C.U.C.U.G.U.C.C.A.C.A.U.A.G.U.U 3′(SEQ ID NO：119)
Cond-siRNA向导：5′CCAC
A.U.A.G.C.C.U.C.U.G.U.C.C.A.C.A.U.A.G.U.U 3′(SEQ ID NO：120)
将人(NM_001527)和大鼠(NM_053447)HDAC2 mRNA这两者作为靶向的候选siRNA向导链序列(反义)和相应的靶向位点(正义)
正义：5′G.C.G.G.A.U.A.G.C.U.U.G.U.G.A.U.G.A.A.U.U 3′(SEQ ID NO：121)
反义：5′U.U.C.A.U.C.A.C.A.A.G.C.U.A.U.C.C.G.C.U.U 3′(SEQ ID NO：122)
Cond-siRNA向导：5′CCAC
U.U.C.A.U.C.A.C.A.A.G.C.U.A.U.C.C.G.C.U.U3′(SEQ ID NO：123)
正义：5′G.G.A.U.A.U.U.G.G.U.G.C.U.G.G.A.A.A.A.U.U 3′(SEQ ID NO：124)
反义：5′U.U.U.U.C.C.A.G.C.A.C.C.A.A.U.A.U.C.C.U.U 3′(SEQ ID NO：125)
Cond-siRNA向导：5′CCAC
U.U.U.U.C.C.A.G.C.A.C.C.A.A.U.A.U.C.C.U.U 3′(SEQ ID NO：126)
正义：5′A.A.G.C.A.G.A.U.G.C.A.G.A.G.A.U.U.U.A.U.U 3′(SEQ ID NO：127)
反义：5′U.A.A.A.U.C.U.C.U.G.C.A.U.C.U.G.C.U.U.U.U3′(SEQ ID NO：128)
Cond-siRNA向导：5′CCAC U.A.A.A.U.C.U.C.U.G.C.A.U.C.U.G.C.U.U.U.U3′(SEQID NO：129)
实施例7：miRNA传感器链的示例性设计
miRNA传感器链的示例性设计如下所示。
miRNA在哺乳动物物种中具有高度保有(conserve)的序列。因此，我们可为包括人在内的所有测试动物设计一个单一的miRNA传感器。
对于每个序列，我们首先取向导序列的反向互补，然后添加8个碱基以创建29nt传感器。
＞hsa-miR-23a-3p MIMAT0000078
＞反向互补
＞传感器，添加8个碱基以产生29mer
Nupack显示最小的二级结构并且不接受自我碱基配对
＞hsa-miR-125b-5p MIMAT0000423
＞反向互补
＞传感器，添加7个碱基以产生29mer，
使用二级结构预测编码确保二级结构相对开放。如果不是，则改变所添加的碱基并重试。
＞hsa-miR-199b-5p MIMAT0000263
＞反向互补
＞传感器，添加6个碱基以产生29mer，
可接受的低二级结构
实施例8：miRNAs
其他miRNA如下所示：
＞rno-miR-23a-3p MIMAT0000792
＞hsa-miR-23a-3p MIMAT0000078
＞rno-miR-23a-3p MIMAT0000792
＞mmu-miR-125b-5p MIMAT0000136
＞hsa-miR-125b-5p MIMAT0000423
＞rno-miR-125b-5p MIMAT0000830
＞hsa-miR-199b-5p MIMAT0000263
＞mmu-miR-199b-5p MIMAT0000672
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16 Jaramillo-Botero，A.，Nielsen，R.，Abrol，R.，Su，J.，Pascal，T.，Mueller，J.&Goddard，W.Vol.307当前化学主题(Topics in Current Chemistry)(eds BarbaraKirchner&Jadran Vrabec)1-42(Springer Berlin/Heidelberg，2012).
17 Naito，Y.&Ui-Tei，K.siRNA设计：方法和方案(in siRNA Design：Methods andProtocols)(ed Debra J.Taxman)57-68(Humana Press，2013).
18 Boudreau，R.L.，Spengler，R.M.&Davidson，B.L.治疗性siRNA的合理设计：最大程度地降低脱靶潜能，以提高针对亨延顿氏病的RNAi疗法的安全性(Rational Designof Therapeutic siRNAs：Minimizing Off-targeting Potential to Improve theSafety of RNAi Therapy for Huntington′s Disease).Mol Ther，doi：http://www.nature.com/mt/journal/vaop/ncurrent/suppinfo/mt2011185s1.html(2011).
19 Sano，M.，Sierant，M.，Miyagishi，M.，Nakanishi，M.，Takagi，Y.&Sutou，S.短RNA双链体的不对称末端结构对RNA干扰活性和链选择的影响(Effect of asymmetricterminal structures of short RNA duplexes on the RNA interference activityand strand selection).Nucleic Acids Research 36，5812-5821，doi：10.1093/nar/gkn584(2008).
1.KonStam MA，Kramer DG，Patel AR，Maron MS，Udelson JE.心力衰竭中的左心室重塑：当前的临床意义和评估概念(Left ventricular remodeling in heart failure：current concepts in clinical significance and assessment).JACC CardiovascImaging.2011；4(1)：98-108.doi：10.1016/j.jcmg.2010.10.008.
2.Rij RPV.病毒遇到RNAi。RNA干扰的抗病毒应用研讨会(Virus meetsRNAi.Symposium on Antiviral Applications of RNA Interference).EMBOReports.2008；9(8)：725-729.doi：10.1038/embor.2008.133.
3.J.N.Zadeh，C.D.Steenberg，J.S.Bois，B.R.Wolfe，M.B.Pierce，A.R.Khan，R.M.Dirks，N.A.Pierce.NUPACK：核酸系统的分析和设计(NUPACK：analysis and designofnucleic acid systems).J Comput Chem.32：170-173，2011.
4.Jessup M，Brozena S.心力衰竭(Heart Failure).New England Journal ofMedicine.2003；348：2007-2018.doi：10.1056/NEJMra021498.
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序列表
<110> 希望之城
加州理工学院
通用医疗公司
<120> 条件性-siRNA及其在治疗心肌肥大中的用途
<130> 054435-8174.CN00
<140> PCT/US2018/046379
<141> 2018-08-10
<150> 62/543,882
<151> 2017-08-10
<160> 1307
<170> PatentIn version 3.5
<210> 1
<211> 29
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide (组合的DNA/RNA分子的描述:合成寡核苷酸)
<400> 1
cgaagaacgg aaaucccugg caaugtgat 29
<210> 2
<211> 29
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide (组合的DNA/RNA分子的描述:合成寡核苷酸)
<400> 2
cgaagaacgg aaauccctgg caatgtgau 29
<210> 3
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 3
ggagaagaac ggaaaucccu ggcaauguga u 31
<210> 4
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 4
aucagaagca ggugucugca gccaggacuu c 31
<210> 5
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 5
cuuguggaau cagaagcagg ugucugcagc c 31
<210> 6
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 6
caaaggcggc cacaggguug aggaaaaagc c 31
<210> 7
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 7
aucuugaucu gcucagcccu ggaggugcca g 31
<210> 8
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 8
caacaagaug acacaaaugc agcagagacc c 31
<210> 9
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 9
augacacaaa ugcagcagag accccagggg a 31
<210> 10
<211> 31
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide (组合的DNA/RNA分子的描述:合成寡核苷酸)
<400> 10
ctucaccacc ucucagtggc aaugcgacca a 31
<210> 11
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 11
cgaguguugu uuggcuuuuc cuguu 25
<210> 12
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 12
cgaguguugu uuggcuuuuc cuguu 25
<210> 13
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 13
gcacuuagau ugaaacaacc caguu 25
<210> 14
<211> 23
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 14
uguuaucugg uguuauugac cgu 23
<210> 15
<211> 23
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 15
cgagaucugg uguuauugac cgu 23
<210> 16
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 16
gcucuuagau ugaaacaacc caguu 25
<210> 17
<211> 11
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 17
cguucuucuc c 11
<210> 18
<211> 12
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 18
gucaucuugu ug 12
<210> 19
<211> 11
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 19
agguggugaa g 11
<210> 20
<211> 46
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 20
cguucuucuc ccuggguugu uucaaucuaa gugcgccagg gauuuc 46
<210> 21
<211> 12
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 21
ccugcuucug au 12
<210> 22
<211> 11
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 22
gauuccacaa g 11
<210> 23
<211> 11
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 23
ggccgccuuu g 11
<210> 24
<211> 12
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 24
gcagaucaag au 12
<210> 25
<211> 46
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 25
gucaucuugu ugcuggguug uuucaaucua agagcgcugc auuugu 46
<210> 26
<211> 44
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 26
cauuuguguc auuguuagau ugaaacaacc cagggucucu gcug 44
<210> 27
<211> 253
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
polynucleotide (人工序列的描述:合成多核苷酸)
<220>
<221> modified_base (修饰的_碱基)
<222> (8)..(16)
<223> a, c, t, g, unknown or other (a, c, t, g, 未知或其他)
<220>
<221> modified_base (修饰的_碱基)
<222> (211)..(214)
<223> a, c, t, g, unknown or other (a, c, t, g, 未知或其他)
<220>
<221> modified_base (修饰的_碱基)
<222> (216)..(217)
<223> a, c, t, g, unknown or other (a, c, t, g, 未知或其他)
<220>
<221> modified_base (修饰的_碱基)
<222> (219)..(222)
<223> a, c, t, g, unknown or other (a, c, t, g, 未知或其他)
<220>
<221> modified_base (修饰的_碱基)
<222> (224)..(253)
<223> a, c, t, g, unknown or other (a, c, t, g, 未知或其他)
<400> 27
tcagccannn nnnnnngagc agatcgcaaa agatcccaag gccttgcggt gtgtcacaca 60
gcttggtcgc attgccactg agaggtggtg aataccctcc tggagctgca gcttcctgtc 120
ttcatctatc acgatcgatg ttaagtgtag atgagtggtt tagtgaggcc ttacctctcc 180
cactctgcat attaaggtag atcctcaccc nnnnannann nncnnnnnnn nnnnnnnnnn 240
nnnnnnnnnn nnn 253
<210> 28
<211> 194
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
polynucleotide (人工序列的描述:合成多核苷酸)
<400> 28
gagcagatcg caaaagatcc caaggccttg cggtgtgtca cacagcttgg tcgcattgcc 60
actgagaggt ggtgaatacc ctcctggagc tgcagcttcc tgtcttcatc tatcacgatc 120
gatgttaagt gtagatgagt ggtttagtga ggccttacct ctcccactct gcatattaag 180
gtagatcctc accc 194
<210> 29
<211> 253
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
polynucleotide (人工序列的描述:合成多核苷酸)
<220>
<221> modified_base (修饰的_碱基)
<222> (1)..(30)
<223> a, c, t, g, unknown or other (a, c, t, g, 未知或其他)
<220>
<221> modified_base (修饰的_碱基)
<222> (32)..(35)
<223> a, c, t, g, unknown or other (a, c, t, g, 未知或其他)
<220>
<221> modified_base (修饰的_碱基)
<222> (37)..(38)
<223> a, c, t, g, unknown or other (a, c, t, g, 未知或其他)
<220>
<221> modified_base (修饰的_碱基)
<222> (40)..(43)
<223> a, c, t, g, unknown or other (a, c, t, g, 未知或其他)
<220>
<221> modified_base (修饰的_碱基)
<222> (238)..(246)
<223> a, c, t, g, unknown or other (a, c, t, g, 未知或其他)
<400> 29
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn gnnnntnntn nnngggtgag gatctacctt 60
aatatgcaga gtgggagagg taaggcctca ctaaaccact catctacact taacatcgat 120
cgtgatagat gaagacagga agctgcagct ccaggagggt attcaccacc tctcagtggc 180
aatgcgacca agctgtgtga cacaccgcaa ggccttggga tcttttgcga tctgctcnnn 240
nnnnnntggc tga 253
<210> 30
<211> 31
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 30
attcaccacc tctcagtggc aatgcgacca a 31
<210> 31
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 31
cuucaccacc ucucaguggc aaugcgacca a 31
<210> 32
<211> 21
<212> RNA
<<213> Unknown (未知)
<220>
<223> Description of Unknown:
Human, rat or mouse target site sequence 未知描述 (人, 大鼠或小鼠靶位点序列)
<400> 32
uguuguuugg cuuuuccugu u 21
<210> 33
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 33
cuucaccacc ucucaguggc aaugcgacca a 31
<210> 34
<211> 31
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide (组合的DNA/RNA分子的描述:合成寡核苷酸)
<400> 34
ctucaccacc ucucagtggc aaugcgacca a 31
<210> 35
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 35
cgaguguugu uuggcuuuuc cuguu 25
<210> 36
<211> 11
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 36
agguggugaa g 11
<210> 37
<211> 21
<212> RNA
<213> Homo sapiens (智人)
<400> 37
aucacauugc cagggauuuc c 21
<210> 38
<211> 21
<212> RNA
<213> Homo sapiens (智人)
<400> 38
ggaaaucccu ggcaauguga u 21
<210> 39
<211> 29
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 39
cgaagaacgg aaaucccugg caaugugau 29
<210> 40
<211> 8
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 40
cgaagaac 8
<210> 41
<211> 11
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 41
uccguucuuc g 11
<210> 42
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 42
cgaguguugu uuggcuuuuc cuguu 25
<210> 43
<211> 29
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide (组合的DNA/RNA分子的描述:合成寡核苷酸)
<400> 43
cgaagaacgg aaaucccugg caaugtgat 29
<210> 44
<211> 11
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 44
uccguucuuc g 11
<210> 45
<211> 23
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 45
caggaaaagc caaacaacac ucg 23
<210> 46
<211> 12
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 46
gccagggauu uc 12
<210> 47
<211> 11
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 47
gcugcauuug u 11
<210> 48
<211> 12
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 48
auugccacug ag 12
<210> 49
<211> 23
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 49
acggucaaua acaccagauc ucg 23
<210> 50
<211> 11
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 50
ggcugcagac a 11
<210> 51
<211> 12
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 51
acaccugcuu cu 12
<210> 52
<211> 12
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 52
ccucaacccu gu 12
<210> 53
<211> 11
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 53
uccagggcug a 11
<210> 54
<211> 23
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 54
caggaaaagc caaacaacac ucg 23
<210> 55
<211> 12
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 55
auugccacug ag 12
<210> 56
<211> 11
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 56
ugccagggau u 11
<210> 57
<211> 11
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 57
ugccagggau u 11
<210> 58
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 58
ccacuuuacc agcaucucag ucauu 25
<210> 59
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 59
ggagaggcga ggaagucacc aucaaaccac u 31
<210> 60
<211> 46
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 60
cucgccucuc cugacugaga ugcugguaaa gugggauggu gacuuc 46
<210> 61
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 61
ccacuuuacc agcaucucag ucauu 25
<210> 62
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 62
ggaaucagaa gcaggugucu gcagccagga c 31
<210> 63
<211> 46
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 63
cuucugauuc cugacugaga ugcugguaaa guggugcaga caccug 46
<210> 64
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 64
ccacuuuacc agcaucucag ucauu 25
<210> 65
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 65
ccaaggagcu guuacacagg cuccagcaug g 31
<210> 66
<211> 46
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 66
cagcuccuug gugacugaga ugcugguaaa gugggagccu guguaa 46
<210> 67
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 67
ccacuucauc acaagcuauc cgcuu 25
<210> 68
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 68
ggagaggcga ggaagucacc aucaaaccac u 31
<210> 69
<211> 46
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 69
cucgccucuc cgcggauagc uugugaugaa gugggauggu gacuuc 46
<210> 70
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 70
ccacuucauc acaagcuauc cgcuu 25
<210> 71
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 71
ggaaucagaa gcaggugucu gcagccagga c 31
<210> 72
<211> 46
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 72
cuucugauuc cgcggauagc uugugaugaa guggugcaga caccug 46
<210> 73
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 73
ccacuucauc acaagcuauc cgcuu 25
<210> 74
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 74
ccaaggagcu guuacacagg cuccagcaug g 31
<210> 75
<211> 46
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 75
cagcuccuug ggcggauagc uugugaugaa gugggagccu guguaa 46
<210> 76
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 76
ccacuuuacc agcaucucag ucauu 25
<210> 77
<211> 29
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 77
cgaagaacgg aaaucccugg caaugugau 29
<210> 78
<211> 45
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 78
uccguucuuc gugacugaga ugcugguaaa guggugccag ggauu 45
<210> 79
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 79
ccacuuuacc agcaucucag ucauu 25
<210> 80
<211> 29
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 80
cgacaguuca caaguuaggg ucucaggga 29
<210> 81
<211> 45
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 81
gugaacuguc gugacugaga ugcugguaaa gugggacccu aacuu 45
<210> 82
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 82
ccacuuuacc agcaucucag ucauu 25
<210> 83
<211> 29
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 83
ccugaagaac agauagucua aacacuggg 29
<210> 84
<211> 45
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 84
uguucuucag gugacugaga ugcugguaaa gugguuuaga cuauc 45
<210> 85
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 85
ccacuucauc acaagcuauc cgcuu 25
<210> 86
<211> 29
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 86
cgaagaacgg aaaucccugg caaugugau 29
<210> 87
<211> 47
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 87
aacagcuccu ugggcggaua gcuugugaug aaguggggag ccugugu 47
<210> 88
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 88
ccacuucauc acaagcuauc cgcuu 25
<210> 89
<211> 29
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 89
cgacaguuca caaguuaggg ucucaggga 29
<210> 90
<211> 45
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 90
uccguucuuc ggcggauagc uugugaugaa guggugccag ggauu 45
<210> 91
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 91
ccacuucauc acaagcuauc cgcuu 25
<210> 92
<211> 29
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 92
ccugaagaac agauagucua aacacuggg 29
<210> 93
<211> 45
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 93
uguucuucag ggcggauagc uugugaugaa gugguuuaga cuauc 45
<210> 94
<211> 21
<212> RNA
<213> Unknown (未知)
<220>
<223> Description of Unknown:
Human or rat sense sequence (未知描述:人或大鼠正义序列)
<400> 94
gaacaagauc cgagcaauau u 21
<210> 95
<211> 21
<212> RNA
<213> Unknown (未知)
<220>
<223> Description of Unknown:
Human or rat antisense sequence (未知的描述:人或大鼠反义序列)
<400> 95
uauugcucgg aucuuguucu u 21
<210> 96
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 96
cgacuauugc ucggaucuug uucuu 25
<210> 97
<211> 21
<212> RNA
<213> Unknown (未知)
<220>
<223> Description of Unknown:
Human or rat sense sequence (未知描述:人或大鼠正义序列)
<400> 97
ugacugagau gcugguaaau u 21
<210> 98
<211> 21
<212> RNA
<213> Unknown (未知)
<220>
<223> Description of Unknown:
Human or rat antisense sequence (未知的描述:人或大鼠反义序列)
<400> 98
uuuaccagca ucucagucau u 21
<210> 99
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 99
cgacuuuacc agcaucucag ucauu 25
<210> 100
<211> 21
<212> RNA
<213> Unknown (未知)
<220>
<223> Description of Unknown:
Human or rat sense sequence (未知描述:人或大鼠正义序列)
<400> 100
ggucagaaga agauggauuu u 21
<210> 101
<211> 21
<212> RNA
<213> Unknown (未知)
<220>
<223> Description of Unknown:
Human or rat antisense sequence (未知的描述:人或大鼠反义序列)
<400> 101
aauccaucuu cuucugaccu u 21
<210> 102
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 102
ccacaaucca ucuucuucug accuu 25
<210> 103
<211> 21
<212> RNA
<213> Unknown (未知)
<220>
<223> Description of Unknown:
Human or rat sense sequence (未知描述:人或大鼠正义序列)
<400> 103
gcuauagaau guacagaaau u 21
<210> 104
<211> 21
<212> RNA
<213> Unknown (未知)
<220>
<223> Description of Unknown:
Human or rat antisense sequence (未知的描述:人或大鼠反义序列)
<400> 104
uuucuguaca uucuauagcu u 21
<210> 105
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 105
cgacuuucug uacauucuau agcuu 25
<210> 106
<211> 21
<212> RNA
<213> Unknown (未知)
<220>
<223> Description of Unknown:
Human or rat sense sequence (未知描述:人或大鼠正义序列)
<400> 106
ccuuuaagca ggaauguaau u 21
<210> 107
<211> 21
<212> RNA
<213> Unknown (未知)
<220>
<223> Description of Unknown:
Human or rat antisense sequence (未知的描述:人或大鼠反义序列)
<400> 107
uuacauuccu gcuuaaaggu u 21
<210> 108
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 108
ggacuuacau uccugcuuaa agguu 25
<210> 109
<211> 21
<212> RNA
<213> Unknown (未知)
<220>
<223> Description of Unknown:
Human or rat sense sequence (未知描述:人或大鼠正义序列)
<400> 109
gcaauuggca agauggcaau u 21
<210> 110
<211> 21
<212> RNA
<213> Unknown (未知)
<220>
<223> Description of Unknown:
Human or rat antisense sequence (未知的描述:人或大鼠反义序列)
<400> 110
uugccaucuu gccaauugcu u 21
<210> 111
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 111
ccacuugcca ucuugccaau ugcuu 25
<210> 112
<211> 21
<212> RNA
<213> Unknown (未知)
<220>
<223> Description of Unknown:
Human or rat sense sequence (未知描述:人或大鼠正义序列)
<400> 112
guauagagug ugugcuguau u 21
<210> 113
<211> 21
<212> RNA
<213> Unknown (未知)
<220>
<223> Description of Unknown:
Human or rat antisense sequence (未知的描述:人或大鼠反义序列)
<400> 113
uacagcacac acucuauacu u 21
<210> 114
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 114
ccacuacagc acacacucua uacuu 25
<210> 115
<211> 21
<212> RNA
<213> Unknown (未知)
<220>
<223> Description of Unknown:
Human or rat sense sequence (未知描述:人或大鼠正义序列)
<400> 115
aguauuugag aaugggaaau u 21
<210> 116
<211> 21
<212> RNA
<213> Unknown (未知)
<220>
<223> Description of Unknown:
Human or rat antisense sequence (未知的描述:人或大鼠反义序列)
<400> 116
uuucccauuc ucaaauacuu u 21
<210> 117
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 117
ccacuuuccc auucucaaau acuuu 25
<210> 118
<211> 21
<212> RNA
<213> Unknown (未知)
<220>
<223> Description of Unknown:
Human or rat sense sequence (未知描述:人或大鼠正义序列)
<400> 118
cuauguggac agaggcuauu u 21
<210> 119
<211> 21
<212> RNA
<213> Unknown (未知)
<220>
<223> Description of Unknown:
Human or rat antisense sequence (未知的描述:人或大鼠反义序列)
<400> 119
auagccucug uccacauagu u 21
<210> 120
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 120
ccacauagcc ucuguccaca uaguu 25
<210> 121
<211> 21
<212> RNA
<213> Unknown (未知)
<220>
<223> Description of Unknown:
Human or rat sense sequence (未知描述:人或大鼠正义序列)
<400> 121
gcggauagcu ugugaugaau u 21
<210> 122
<211> 21
<212> RNA
<213> Unknown (未知)
<220>
<223> Description of Unknown:
Human or rat antisense sequence (未知的描述:人或大鼠反义序列)
<400> 122
uucaucacaa gcuauccgcu u 21
<210> 123
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 123
ccacuucauc acaagcuauc cgcuu 25
<210> 124
<211> 21
<212> RNA
<213> Unknown (未知)
<220>
<223> Description of Unknown:
Human or rat sense sequence (未知描述:人或大鼠正义序列)
<400> 124
ggauauuggu gcuggaaaau u 21
<210> 125
<211> 21
<212> RNA
<213> Unknown (未知)
<220>
<223> Description of Unknown:
Human or rat antisense sequence (未知的描述:人或大鼠反义序列)
<400> 125
uuuuccagca ccaauauccu u 21
<210> 126
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 126
ccacuuuucc agcaccaaua uccuu 25
<210> 127
<211> 21
<212> RNA
<213> Unknown (未知)
<220>
<223> Description of Unknown:
Human or rat sense sequence (未知描述:人或大鼠正义序列)
<400> 127
aagcagaugc agagauuuau u 21
<210> 128
<211> 21
<212> RNA
<213> Unknown (未知)
<220>
<223> Description of Unknown:
Human or rat antisense sequence (未知的描述:人或大鼠反义序列)
<400> 128
uaaaucucug caucugcuuu u 21
<210> 129
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 129
ccacuaaauc ucugcaucug cuuuu 25
<210> 130
<211> 628
<212> DNA
<213> Rattus norvegicus (褐家鼠)
<400> 130
gcgagacaag agagagcagg acaccatcgc agctgcctgg cccatcactt ctgcagcatg 60
gatctccaga aggtgctgcc ccagatgatt ctgctcctgc ttttccttaa tctgtcgccg 120
ctgggaggtc actcccatcc cctgggaagt cctagccagt ctccagaaca atccacgatg 180
cagaagctgc tggagctgat aagagaaaag tcagaggaaa tggctcagag acagctctca 240
aaggaccaag gccctacaaa agaacttcta aaaagagtcc ttaggtctca agacagcgcc 300
ttccggatcc aggagagact tcgaaattcc aagatggcac atagttcaag ctgctttggg 360
cagaagatag accggatcgg cgcagtcagt cgcttgggct gtgacgggct gaggttgttt 420
taggaagacc tcctggctgc agactccggc ttctgactct gcctgcggct cttctttccc 480
cagctctggg accacctctc aagtgatcct gtttatttat ttgtttattt atttattttt 540
atgttgctga ttttctacaa gactgtttct tatcttccag cacaaacttg ccacagtgta 600
ataaacatag cctatttctt gcttttgg 628
<210> 131
<211> 831
<212> DNA
<213> Rattus norvegicus (褐家鼠)
<400> 131
cggacaaagg ctgagagaga aaccagagag tgagccgaga cagcaaacat cagatcgtgc 60
cccgacccac gccagcatgg gctccttctc catcaccaag ggcttcttcc tcttcctggc 120
cttttggctc ccaggccata ttggagcaaa tcccgtatac agtgcggtgt ccaacacaga 180
tctgatggat ttcaagaacc tgctagacca cctggaggag aagatgccgg tagaagatga 240
ggtcatgcct ccgcaggccc tgagcgagca gaccgatgaa gcgggggcgg cacttagctc 300
cctctctgag gtgcctccct ggactgggga agtcaacccg tctcagagag atggaggtgc 360
tctcgggcgc ggcccctggg acccctccga tagatctgcc ctcttgaaaa gcaaactgag 420
ggctctgctc gctggccctc ggagcctgcg aaggtcaagc tgcttcgggg gtaggattga 480
caggattgga gcccagagcg gactaggctg caacagcttc cggtaccgaa gataacagcc 540
aaatctgctc gagcagatcg caaaagatcc caagcccttg cggtgtgtca cacagcttgg 600
tcgcattgcc actgagaggt ggtgaatacc ctcctggagc tgcagcttcc tgtcttcatc 660
tatcacgatc gatgttaagt gtagatgagt ggtttagtga ggccttacct ctcccactct 720
gcatattaag gtagatcctc acccctttca gaaagcagtt ggaaaaaaat aaatccgaat 780
aaacttcagc accacggaca gacgctgagg cctgaaaaaa aaaaaaaaaa a 831
<210> 132
<211> 152
<212> PRT
<213> Rattus norvegicus (褐家鼠)
<400> 132
Met Gly Ser Phe Ser Ile Thr Lys Gly Phe Phe Leu Phe Leu Ala Phe
1 5 10 15
Trp Leu Pro Gly His Ile Gly Ala Asn Pro Val Tyr Ser Ala Val Ser
20 25 30
Asn Thr Asp Leu Met Asp Phe Lys Asn Leu Leu Asp His Leu Glu Glu
35 40 45
Lys Met Pro Val Glu Asp Glu Val Met Pro Pro Gln Ala Leu Ser Glu
50 55 60
Gln Thr Asp Glu Ala Gly Ala Ala Leu Ser Ser Leu Ser Glu Val Pro
65 70 75 80
Pro Trp Thr Gly Glu Val Asn Pro Ser Gln Arg Asp Gly Gly Ala Leu
85 90 95
Gly Arg Gly Pro Trp Asp Pro Ser Asp Arg Ser Ala Leu Leu Lys Ser
100 105 110
Lys Leu Arg Ala Leu Leu Ala Gly Pro Arg Ser Leu Arg Arg Ser Ser
115 120 125
Cys Phe Gly Gly Arg Ile Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly
130 135 140
Cys Asn Ser Phe Arg Tyr Arg Arg
145 150
<210> 133
<211> 22
<212> RNA
<213> Homo sapiens (智人)
<400> 133
ucccugagac ccuaacuugu ga 22
<210> 134
<211> 22
<212> RNA
<213> Homo sapiens (智人)
<400> 134
ucacaaguua gggucucagg ga 22
<210> 135
<211> 29
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 135
cgacaguuca caaguuaggg ucucaggga 29
<210> 136
<211> 23
<212> RNA
<213> Homo sapiens (智人)
<400> 136
cccaguguuu agacuaucug uuc 23
<210> 137
<211> 23
<212> RNA
<213> Homo sapiens (智人)
<400> 137
gaacagauag ucuaaacacu ggg 23
<210> 138
<211> 29
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 138
ccugaagaac agauagucua aacacuggg 29
<210> 139
<211> 21
<212> RNA
<213> Rattus norvegicus (褐家鼠)
<400> 139
aucacauugc cagggauuuc c 21
<210> 140
<211> 121
<212> PRT
<213> Rattus norvegicus (褐家鼠)
<400> 140
Met Asp Leu Gln Lys Val Leu Pro Gln Met Ile Leu Leu Leu Leu Phe
1 5 10 15
Leu Asn Leu Ser Pro Leu Gly Gly His Ser His Pro Leu Gly Ser Pro
20 25 30
Ser Gln Ser Pro Glu Gln Ser Thr Met Gln Lys Leu Leu Glu Leu Ile
35 40 45
Arg Glu Lys Ser Glu Glu Met Ala Gln Arg Gln Leu Ser Lys Asp Gln
50 55 60
Gly Pro Thr Lys Glu Leu Leu Lys Arg Val Leu Arg Ser Gln Asp Ser
65 70 75 80
Ala Phe Arg Ile Gln Glu Arg Leu Arg Asn Ser Lys Met Ala His Ser
85 90 95
Ser Ser Cys Phe Gly Gln Lys Ile Asp Arg Ile Gly Ala Val Ser Arg
100 105 110
Leu Gly Cys Asp Gly Leu Arg Leu Phe
115 120
<210> 141
<211> 21
<212> RNA
<213> Rattus norvegicus (褐家鼠)
<400> 141
aucacauugc cagggauuuc c 21
<210> 142
<211> 22
<212> RNA
<213> Mus musculus (小家鼠)
<400> 142
ucccugagac ccuaacuugu ga 22
<210> 143
<211> 22
<212> RNA
<213> Homo sapiens (智人)
<400> 143
ucccugagac ccuaacuugu ga 22
<210> 144
<211> 22
<212> RNA
<213> Rattus norvegicus (褐家鼠)
<400> 144
ucccugagac ccuaacuugu ga 22
<210> 145
<211> 23
<212> RNA
<213> Homo sapiens (智人)
<400> 145
cccaguguuu agacuaucug uuc 23
<210> 146
<211> 23
<212> RNA
<213> Mus musculus (小家鼠)
<400> 146
cccaguguuu agacuaccug uuc 23
<210> 147
<211> 29
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide (组合的DNA/RNA分子的描述:合成寡核苷酸)
<400> 147
cgaagaacgg aaauccctgg caatgtgau 29
<210> 148
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 148
ccaaggagcu guuacacagg cuccagcaug g 31
<210> 149
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 149
ggcuccagca uggggcuuug cuggcaccuc c 31
<210> 150
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 150
ccagggcuga gcagaucaag auguggcaaa g 31
<210> 151
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 151
cagggcugag cagaucaaga uguggcaaag c 31
<210> 152
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 152
gcuggcaccu ccagggcuga gcagaucaag a 31
<210> 153
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 153
caggcuccag cauggggcuu ugcuggcacc u 31
<210> 154
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 154
aggcuccagc auggggcuuu gcuggcaccu c 31
<210> 155
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 155
gcuccagcau ggggcuuugc uggcaccucc a 31
<210> 156
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 156
cuccagcaug gggcuuugcu ggcaccucca g 31
<210> 157
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 157
uccagcaugg ggcuuugcug gcaccuccag g 31
<210> 158
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 158
auucugcuuc cucccaagga gcuguuacac a 31
<210> 159
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 159
uccagggcug agcagaucaa gauguggcaa a 31
<210> 160
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 160
uguuacacag gcuccagcau ggggcuuugc u 31
<210> 161
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 161
cuccagggcu gagcagauca agauguggca a 31
<210> 162
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 162
cucccaagga gcuguuacac aggcuccagc a 31
<210> 163
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 163
cccaaggagc uguuacacag gcuccagcau g 31
<210> 164
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 164
caaggagcug uuacacaggc uccagcaugg g 31
<210> 165
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 165
aaggagcugu uacacaggcu ccagcauggg g 31
<210> 166
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 166
gcuguuacac aggcuccagc auggggcuuu g 31
<210> 167
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 167
cuguuacaca ggcuccagca uggggcuuug c 31
<210> 168
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 168
guuacacagg cuccagcaug gggcuuugcu g 31
<210> 169
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 169
uuacacaggc uccagcaugg ggcuuugcug g 31
<210> 170
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 170
cuggcaccuc cagggcugag cagaucaaga u 31
<210> 171
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 171
uggcaccucc agggcugagc agaucaagau g 31
<210> 172
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 172
ggcaccucca gggcugagca gaucaagaug u 31
<210> 173
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 173
gcaccuccag ggcugagcag aucaagaugu g 31
<210> 174
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 174
caccuccagg gcugagcaga ucaagaugug g 31
<210> 175
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 175
accuccaggg cugagcagau caagaugugg c 31
<210> 176
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 176
ccuccagggc ugagcagauc aagauguggc a 31
<210> 177
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 177
ccucccaagg agcuguuaca caggcuccag c 31
<210> 178
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 178
aggagcuguu acacaggcuc cagcaugggg c 31
<210> 179
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 179
uacacaggcu ccagcauggg gcuuugcugg c 31
<210> 180
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 180
gcuuugcugg caccuccagg gcugagcaga u 31
<210> 181
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 181
cuuugcuggc accuccaggg cugagcagau c 31
<210> 182
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 182
ugcuggcacc uccagggcug agcagaucaa g 31
<210> 183
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 183
cacaggcucc agcauggggc uuugcuggca c 31
<210> 184
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 184
acaggcucca gcauggggcu uugcuggcac c 31
<210> 185
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 185
ggcuuugcug gcaccuccag ggcugagcag a 31
<210> 186
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 186
uucugcuucc ucccaaggag cuguuacaca g 31
<210> 187
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 187
ucugcuuccu cccaaggagc uguuacacag g 31
<210> 188
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 188
ugcuuccucc caaggagcug uuacacaggc u 31
<210> 189
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 189
uuccucccaa ggagcuguua cacaggcucc a 31
<210> 190
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 190
ucccaaggag cuguuacaca ggcuccagca u 31
<210> 191
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 191
agcuguuaca caggcuccag cauggggcuu u 31
<210> 192
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 192
cugcuuccuc ccaaggagcu guuacacagg c 31
<210> 193
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 193
gcuuccuccc aaggagcugu uacacaggcu c 31
<210> 194
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 194
cuuccuccca aggagcuguu acacaggcuc c 31
<210> 195
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 195
uccucccaag gagcuguuac acaggcucca g 31
<210> 196
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 196
gagcuguuac acaggcucca gcauggggcu u 31
<210> 197
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 197
uuugcuggca ccuccagggc ugagcagauc a 31
<210> 198
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 198
uugcuggcac cuccagggcu gagcagauca a 31
<210> 199
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 199
ggagcuguua cacaggcucc agcauggggc u 31
<210> 200
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 200
acacaggcuc cagcaugggg cuuugcuggc a 31
<210> 201
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 201
gcauggggcu uugcuggcac cuccagggcu g 31
<210> 202
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 202
uggggcuuug cuggcaccuc cagggcugag c 31
<210> 203
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 203
cuucaaggaa aauugcuuua uucugcuucc u 31
<210> 204
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 204
uucaaggaaa auugcuuuau ucugcuuccu c 31
<210> 205
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 205
ucaaggaaaa uugcuuuauu cugcuuccuc c 31
<210> 206
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 206
uugcuuuauu cugcuuccuc ccaaggagcu g 31
<210> 207
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 207
ugcuuuauuc ugcuuccucc caaggagcug u 31
<210> 208
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 208
gcuuuauucu gcuuccuccc aaggagcugu u 31
<210> 209
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 209
agcauggggc uuugcuggca ccuccagggc u 31
<210> 210
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 210
cauggggcuu ugcuggcacc uccagggcug a 31
<210> 211
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 211
auggggcuuu gcuggcaccu ccagggcuga g 31
<210> 212
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 212
ccagcauggg gcuuugcugg caccuccagg g 31
<210> 213
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 213
cagcaugggg cuuugcuggc accuccaggg c 31
<210> 214
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 214
ggggcuuugc uggcaccucc agggcugagc a 31
<210> 215
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 215
gggcuuugcu ggcaccucca gggcugagca g 31
<210> 216
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 216
gcuucaagga aaauugcuuu auucugcuuc c 31
<210> 217
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 217
auugcuuuau ucugcuuccu cccaaggagc u 31
<210> 218
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 218
cuuuauucug cuuccuccca aggagcuguu a 31
<210> 219
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 219
uuuauucugc uuccucccaa ggagcuguua c 31
<210> 220
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 220
uuauucugcu uccucccaag gagcuguuac a 31
<210> 221
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 221
uauucugcuu ccucccaagg agcuguuaca c 31
<210> 222
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 222
ucggcuucaa ggaaaauugc uuuauucugc u 31
<210> 223
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 223
cggcuucaag gaaaauugcu uuauucugcu u 31
<210> 224
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 224
ggcuucaagg aaaauugcuu uauucugcuu c 31
<210> 225
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 225
cucggcuuca aggaaaauug cuuuauucug c 31
<210> 226
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 226
aaggaaaauu gcuuuauucu gcuuccuccc a 31
<210> 227
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 227
aggaaaauug cuuuauucug cuuccuccca a 31
<210> 228
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 228
aaaauugcuu uauucugcuu ccucccaagg a 31
<210> 229
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 229
caaggaaaau ugcuuuauuc ugcuuccucc c 31
<210> 230
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 230
ggaaaauugc uuuauucugc uuccucccaa g 31
<210> 231
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 231
gaaaauugcu uuauucugcu uccucccaag g 31
<210> 232
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 232
aaauugcuuu auucugcuuc cucccaagga g 31
<210> 233
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 233
aauugcuuua uucugcuucc ucccaaggag c 31
<210> 234
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 234
guguuucugc cuaaggugcu guuucaaagg c 31
<210> 235
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 235
guuucugccu aaggugcugu uucaaaggcu c 31
<210> 236
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 236
uuucugccua aggugcuguu ucaaaggcuc c 31
<210> 237
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 237
uguguuucug ccuaaggugc uguuucaaag g 31
<210> 238
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 238
uguuucugcc uaaggugcug uuucaaaggc u 31
<210> 239
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 239
uuguguuucu gccuaaggug cuguuucaaa g 31
<210> 240
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 240
auuguguuuc ugccuaaggu gcuguuucaa a 31
<210> 241
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 241
cugccuaagg ugcuguuuca aaggcuccag g 31
<210> 242
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 242
gccuaaggug cuguuucaaa ggcuccaggu c 31
<210> 243
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 243
aggugcuguu ucaaaggcuc caggucucag g 31
<210> 244
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 244
ucugccuaag gugcuguuuc aaaggcucca g 31
<210> 245
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 245
ugccuaaggu gcuguuucaa aggcuccagg u 31
<210> 246
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 246
ccuaaggugc uguuucaaag gcuccagguc u 31
<210> 247
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 247
cuaaggugcu guuucaaagg cuccaggucu c 31
<210> 248
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 248
uucugccuaa ggugcuguuu caaaggcucc a 31
<210> 249
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 249
aaggugcugu uucaaaggcu ccaggucuca g 31
<210> 250
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 250
uaaggugcug uuucaaaggc uccaggucuc a 31
<210> 251
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 251
uugcuuuauu guguuucugc cuaaggugcu g 31
<210> 252
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 252
ugcuuuauug uguuucugcc uaaggugcug u 31
<210> 253
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 253
gcuuuauugu guuucugccu aaggugcugu u 31
<210> 254
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 254
cuuuauugug uuucugccua aggugcuguu u 31
<210> 255
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 255
uuuauugugu uucugccuaa ggugcuguuu c 31
<210> 256
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 256
auugcuuuau uguguuucug ccuaaggugc u 31
<210> 257
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 257
uuauuguguu ucugccuaag gugcuguuuc a 31
<210> 258
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 258
ggcuccaggu cucagggcuu cacaggcauc c 31
<210> 259
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 259
caaaggcucc aggucucagg gcuucacagg c 31
<210> 260
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 260
gcuccagguc ucagggcuuc acaggcaucc u 31
<210> 261
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 261
ggugcuguuu caaaggcucc aggucucagg g 31
<210> 262
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 262
gugcuguuuc aaaggcucca ggucucaggg c 31
<210> 263
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 263
aaaggcucca ggucucaggg cuucacaggc a 31
<210> 264
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 264
cuccaggucu cagggcuuca caggcauccu u 31
<210> 265
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 265
ugcuguuuca aaggcuccag gucucagggc u 31
<210> 266
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 266
gcuguuucaa aggcuccagg ucucagggcu u 31
<210> 267
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 267
cuguuucaaa ggcuccaggu cucagggcuu c 31
<210> 268
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 268
uauuguguuu cugccuaagg ugcuguuuca a 31
<210> 269
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 269
aggcuccagg ucucagggcu ucacaggcau c 31
<210> 270
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 270
ucaaaggcuc caggucucag ggcuucacag g 31
<210> 271
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 271
aaggcuccag gucucagggc uucacaggca u 31
<210> 272
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 272
ccaggucuca gggcuucaca ggcauccuua g 31
<210> 273
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 273
caggucucag ggcuucacag gcauccuuag g 31
<210> 274
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 274
guuucaaagg cuccaggucu cagggcuuca c 31
<210> 275
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 275
uccaggucuc agggcuucac aggcauccuu a 31
<210> 276
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 276
uguuucaaag gcuccagguc ucagggcuuc a 31
<210> 277
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 277
uucaaaggcu ccaggucuca gggcuucaca g 31
<210> 278
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 278
uuucaaaggc uccaggucuc agggcuucac a 31
<210> 279
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 279
ggcuugaagg aaaauugcuu uauuguguuu c 31
<210> 280
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 280
gcuugaagga aaauugcuuu auuguguuuc u 31
<210> 281
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 281
cuugaaggaa aauugcuuua uuguguuucu g 31
<210> 282
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 282
uugaaggaaa auugcuuuau uguguuucug c 31
<210> 283
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 283
ugaaggaaaa uugcuuuauu guguuucugc c 31
<210> 284
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 284
gaaggaaaau ugcuuuauug uguuucugcc u 31
<210> 285
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 285
ggaaaauugc uuuauugugu uucugccuaa g 31
<210> 286
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 286
gaaaauugcu uuauuguguu ucugccuaag g 31
<210> 287
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 287
aaauugcuuu auuguguuuc ugccuaaggu g 31
<210> 288
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 288
aaggaaaauu gcuuuauugu guuucugccu a 31
<210> 289
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 289
aggaaaauug cuuuauugug uuucugccua a 31
<210> 290
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 290
aaaauugcuu uauuguguuu cugccuaagg u 31
<210> 291
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 291
ggucucaggg cuucacaggc auccuuaggg u 31
<210> 292
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 292
cucagggcuu cacaggcauc cuuaggguug g 31
<210> 293
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 293
ggcuucacag gcauccuuag gguuggguag c 31
<210> 294
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 294
gucucagggc uucacaggca uccuuagggu u 31
<210> 295
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 295
ucucagggcu ucacaggcau ccuuaggguu g 31
<210> 296
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 296
aauugcuuua uuguguuucu gccuaaggug c 31
<210> 297
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 297
aggucucagg gcuucacagg cauccuuagg g 31
<210> 298
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 298
gcuucacagg cauccuuagg guuggguagc a 31
<210> 299
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 299
cuucacaggc auccuuaggg uuggguagca c 31
<210> 300
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 300
cacaggcauc cuuaggguug gguagcacaa g 31
<210> 301
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 301
acaggcaucc uuaggguugg guagcacaag a 31
<210> 302
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 302
caggcauccu uaggguuggg uagcacaaga u 31
<210> 303
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 303
uucacaggca uccuuagggu uggguagcac a 31
<210> 304
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 304
ucacaggcau ccuuaggguu ggguagcaca a 31
<210> 305
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 305
ucagggcuuc acaggcaucc uuaggguugg g 31
<210> 306
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 306
cagggcuuca caggcauccu uaggguuggg u 31
<210> 307
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 307
gggcuucaca ggcauccuua ggguugggua g 31
<210> 308
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 308
agggcuucac aggcauccuu aggguugggu a 31
<210> 309
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 309
ggagaggcga ggaagucacc aucaaaccac u 31
<210> 310
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 310
agaugugaga aguguugaca ggaagcugca g 31
<210> 311
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 311
uaagauguga gaaguguuga caggaagcug c 31
<210> 312
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 312
aagaugugag aaguguugac aggaagcugc a 31
<210> 313
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 313
auucacuuuc aaaccacuuu caguaacagg u 31
<210> 314
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 314
gagaggcgag gaagucacca ucaaaccacu u 31
<210> 315
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 315
gaugugagaa guguugacag gaagcugcag c 31
<210> 316
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 316
augugagaag uguugacagg aagcugcagc u 31
<210> 317
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 317
ugugagaagu guugacagga agcugcagcu u 31
<210> 318
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 318
gugagaagug uugacaggaa gcugcagcuu a 31
<210> 319
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 319
ugagaagugu ugacaggaag cugcagcuua g 31
<210> 320
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 320
gagaaguguu gacaggaagc ugcagcuuag a 31
<210> 321
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 321
gaaguguuga caggaagcug cagcuuagau g 31
<210> 322
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 322
aaguguugac aggaagcugc agcuuagaug g 31
<210> 323
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 323
agaaguguug acaggaagcu gcagcuuaga u 31
<210> 324
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 324
gaucacaacu ccauggcaac aagaugacac a 31
<210> 325
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 325
aucacaacuc cauggcaaca agaugacaca a 31
<210> 326
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 326
ucacaacucc auggcaacaa gaugacacaa a 31
<210> 327
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 327
uucacuuuca aaccacuuuc aguaacaggu g 31
<210> 328
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 328
ucacuuucaa accacuuuca guaacaggug a 31
<210> 329
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 329
agaggcgagg aagucaccau caaaccacuu u 31
<210> 330
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 330
ggaugaucac aacuccaugg caacaagaug a 31
<210> 331
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 331
gaugaucaca acuccauggc aacaagauga c 31
<210> 332
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 332
ugaucacaac uccauggcaa caagaugaca c 31
<210> 333
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 333
cacuuucaaa ccacuuucag uaacagguga g 31
<210> 334
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 334
augaucacaa cuccauggca acaagaugac a 31
<210> 335
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 335
aaccacuuuc aguaacaggu gagguucuac c 31
<210> 336
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 336
accacuuuca guaacaggug agguucuacc u 31
<210> 337
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 337
ccacuuucag uaacagguga gguucuaccu u 31
<210> 338
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 338
acuuucaaac cacuuucagu aacaggugag g 31
<210> 339
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 339
cuuucaaacc acuuucagua acaggugagg u 31
<210> 340
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 340
uucaaaccac uuucaguaac aggugagguu c 31
<210> 341
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 341
ucaaaccacu uucaguaaca ggugagguuc u 31
<210> 342
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 342
caaaccacuu ucaguaacag gugagguucu a 31
<210> 343
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 343
aaaccacuuu caguaacagg ugagguucua c 31
<210> 344
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 344
cacuuucagu aacaggugag guucuaccuu a 31
<210> 345
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 345
uuucaaacca cuuucaguaa caggugaggu u 31
<210> 346
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 346
uuuauucacu uucaaaccac uuucaguaac a 31
<210> 347
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 347
gggagaggcg aggaagucac caucaaacca c 31
<210> 348
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 348
ggcaacaaga ugacacaaau gcagcagaga c 31
<210> 349
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 349
gcaacaagau gacacaaaug cagcagagac c 31
<210> 350
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 350
guuagcauaa gaugugagaa guguugacag g 31
<210> 351
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 351
agcauaagau gugagaagug uugacaggaa g 31
<210> 352
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 352
auaagaugug agaaguguug acaggaagcu g 31
<210> 353
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 353
ucaccaucaa accacuuuau cuacaguuag c 31
<210> 354
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 354
caccaucaaa ccacuuuauc uacaguuagc a 31
<210> 355
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 355
aguuagcaua agaugugaga aguguugaca g 31
<210> 356
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 356
uuagcauaag augugagaag uguugacagg a 31
<210> 357
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 357
uagcauaaga ugugagaagu guugacagga a 31
<210> 358
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 358
aagucaccau caaaccacuu uaucuacagu u 31
<210> 359
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 359
agucaccauc aaaccacuuu aucuacaguu a 31
<210> 360
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 360
accaucaaac cacuuuaucu acaguuagca u 31
<210> 361
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 361
ccaucaaacc acuuuaucua caguuagcau a 31
<210> 362
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 362
uacaguuagc auaagaugug agaaguguug a 31
<210> 363
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 363
cugaaguuua uucacuuuca aaccacuuuc a 31
<210> 364
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 364
guuuauucac uuucaaacca cuuucaguaa c 31
<210> 365
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 365
uuauucacuu ucaaaccacu uucaguaaca g 31
<210> 366
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 366
aaguuuauuc acuuucaaac cacuuucagu a 31
<210> 367
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 367
aguuuauuca cuuucaaacc acuuucagua a 31
<210> 368
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 368
ggugggagag gcgaggaagu caccaucaaa c 31
<210> 369
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 369
gugggagagg cgaggaaguc accaucaaac c 31
<210> 370
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 370
ugggagaggc gaggaaguca ccaucaaacc a 31
<210> 371
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 371
ccauggcaac aagaugacac aaaugcagca g 31
<210> 372
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 372
gcauaagaug ugagaagugu ugacaggaag c 31
<210> 373
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 373
cauggcaaca agaugacaca aaugcagcag a 31
<210> 374
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 374
auggcaacaa gaugacacaa augcagcaga g 31
<210> 375
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 375
uggcaacaag augacacaaa ugcagcagag a 31
<210> 376
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 376
cauaagaugu gagaaguguu gacaggaagc u 31
<210> 377
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 377
aggaagucac caucaaacca cuuuaucuac a 31
<210> 378
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 378
gaagucacca ucaaaccacu uuaucuacag u 31
<210> 379
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 379
gucaccauca aaccacuuua ucuacaguua g 31
<210> 380
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 380
cuacaguuag cauaagaugu gagaaguguu g 31
<210> 381
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 381
acaguuagca uaagauguga gaaguguuga c 31
<210> 382
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 382
caguuagcau aagaugugag aaguguugac a 31
<210> 383
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 383
gcugaaguuu auucacuuuc aaaccacuuu c 31
<210> 384
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 384
uauucacuuu caaaccacuu ucaguaacag g 31
<210> 385
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 385
uaucuacagu uagcauaaga ugugagaagu g 31
<210> 386
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 386
aucuacaguu agcauaagau gugagaagug u 31
<210> 387
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 387
ucuacaguua gcauaagaug ugagaagugu u 31
<210> 388
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 388
ugcugaaguu uauucacuuu caaaccacuu u 31
<210> 389
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 389
ugaaguuuau ucacuuucaa accacuuuca g 31
<210> 390
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 390
gaaguuuauu cacuuucaaa ccacuuucag u 31
<210> 391
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 391
aguguugaca ggaagcugca gcuuagaugg g 31
<210> 392
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 392
guguugacag gaagcugcag cuuagauggg a 31
<210> 393
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 393
guugacagga agcugcagcu uagaugggau g 31
<210> 394
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 394
uguugacagg aagcugcagc uuagauggga u 31
<210> 395
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 395
uugacaggaa gcugcagcuu agaugggaug a 31
<210> 396
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 396
ugacaggaag cugcagcuua gaugggauga u 31
<210> 397
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 397
cuccauggca acaagaugac acaaaugcag c 31
<210> 398
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 398
caacuccaug gcaacaagau gacacaaaug c 31
<210> 399
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 399
acuccauggc aacaagauga cacaaaugca g 31
<210> 400
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 400
uccauggcaa caagaugaca caaaugcagc a 31
<210> 401
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 401
cgaggaaguc accaucaaac cacuuuaucu a 31
<210> 402
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 402
gaggaaguca ccaucaaacc acuuuaucua c 31
<210> 403
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 403
ggaagucacc aucaaaccac uuuaucuaca g 31
<210> 404
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 404
cacaacucca uggcaacaag augacacaaa u 31
<210> 405
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 405
acaacuccau ggcaacaaga ugacacaaau g 31
<210> 406
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 406
aacuccaugg caacaagaug acacaaaugc a 31
<210> 407
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 407
gugcugaagu uuauucacuu ucaaaccacu u 31
<210> 408
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 408
ccaggggaca ggagccucuu gcagucuguc c 31
<210> 409
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 409
ggacaggagc cucuugcagu cugucccuag g 31
<210> 410
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 410
gacaggagcc ucuugcaguc ugucccuagg c 31
<210> 411
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 411
acaggagccu cuugcagucu gucccuaggc c 31
<210> 412
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 412
gacaggaagc ugcagcuuag augggaugau c 31
<210> 413
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 413
gaggcgagga agucaccauc aaaccacuuu a 31
<210> 414
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 414
acaggaagcu gcagcuuaga ugggaugauc a 31
<210> 415
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 415
aggaagcugc agcuuagaug ggaugaucac a 31
<210> 416
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 416
ggaagcugca gcuuagaugg gaugaucaca a 31
<210> 417
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 417
gaugggauga ucacaacucc auggcaacaa g 31
<210> 418
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 418
gggaugauca caacuccaug gcaacaagau g 31
<210> 419
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 419
gcgaggaagu caccaucaaa ccacuuuauc u 31
<210> 420
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 420
agaugggaug aucacaacuc cauggcaaca a 31
<210> 421
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 421
augggaugau cacaacucca uggcaacaag a 31
<210> 422
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 422
gucuucuguc cauggugcug aaguuuauuc a 31
<210> 423
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 423
ucuucugucc auggugcuga aguuuauuca c 31
<210> 424
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 424
cuucugucca uggugcugaa guuuauucac u 31
<210> 425
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 425
cuguccaugg ugcugaaguu uauucacuuu c 31
<210> 426
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 426
uucuguccau ggugcugaag uuuauucacu u 31
<210> 427
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 427
ucuguccaug gugcugaagu uuauucacuu u 31
<210> 428
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 428
ccauggugcu gaaguuuauu cacuuucaaa c 31
<210> 429
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 429
cauggugcug aaguuuauuc acuuucaaac c 31
<210> 430
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 430
uggugcugaa guuuauucac uuucaaacca c 31
<210> 431
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 431
ggugcugaag uuuauucacu uucaaaccac u 31
<210> 432
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 432
uccauggugc ugaaguuuau ucacuuucaa a 31
<210> 433
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 433
auggugcuga aguuuauuca cuuucaaacc a 31
<210> 434
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 434
uuucaguaac aggugagguu cuaccuuaaa a 31
<210> 435
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 435
uucaguaaca ggugagguuc uaccuuaaaa u 31
<210> 436
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 436
caggaagcug cagcuuagau gggaugauca c 31
<210> 437
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 437
ggcgaggaag ucaccaucaa accacuuuau c 31
<210> 438
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 438
gaagcugcag cuuagauggg augaucacaa c 31
<210> 439
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 439
aggcgaggaa gucaccauca aaccacuuua u 31
<210> 440
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 440
aagcugcagc uuagauggga ugaucacaac u 31
<210> 441
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 441
uagaugggau gaucacaacu ccauggcaac a 31
<210> 442
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 442
ugggaugauc acaacuccau ggcaacaaga u 31
<210> 443
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 443
uguccauggu gcugaaguuu auucacuuuc a 31
<210> 444
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 444
guccauggug cugaaguuua uucacuuuca a 31
<210> 445
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 445
acuuucagua acaggugagg uucuaccuua a 31
<210> 446
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 446
cuuucaguaa caggugaggu ucuaccuuaa a 31
<210> 447
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 447
gcugcagcuu agaugggaug aucacaacuc c 31
<210> 448
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 448
agcugcagcu uagaugggau gaucacaacu c 31
<210> 449
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 449
cugcagcuua gaugggauga ucacaacucc a 31
<210> 450
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 450
gcagcuuaga ugggaugauc acaacuccau g 31
<210> 451
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 451
cagcuuagau gggaugauca caacuccaug g 31
<210> 452
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 452
agcuuagaug ggaugaucac aacuccaugg c 31
<210> 453
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 453
gcuuagaugg gaugaucaca acuccauggc a 31
<210> 454
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 454
ugcagcuuag augggaugau cacaacucca u 31
<210> 455
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 455
cuuagauggg augaucacaa cuccauggca a 31
<210> 456
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 456
uuagauggga ugaucacaac uccauggcaa c 31
<210> 457
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 457
aaugcagcag agaccccagg ggacaggagc c 31
<210> 458
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 458
ugcagcagag accccagggg acaggagccu c 31
<210> 459
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 459
gcagcagaga ccccagggga caggagccuc u 31
<210> 460
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 460
augcagcaga gaccccaggg gacaggagcc u 31
<210> 461
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 461
caagaugaca caaaugcagc agagacccca g 31
<210> 462
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 462
aagaugacac aaaugcagca gagaccccag g 31
<210> 463
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 463
caacaagaug acacaaaugc agcagagacc c 31
<210> 464
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 464
aacaagauga cacaaaugca gcagagaccc c 31
<210> 465
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 465
acaagaugac acaaaugcag cagagacccc a 31
<210> 466
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 466
caucaaacca cuuuaucuac aguuagcaua a 31
<210> 467
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 467
gcagagaccc caggggacag gagccucuug c 31
<210> 468
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 468
gcauggggug ggagaggcga ggaagucacc a 31
<210> 469
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 469
cagcagagac cccaggggac aggagccucu u 31
<210> 470
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 470
agcagagacc ccaggggaca ggagccucuu g 31
<210> 471
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 471
cagagacccc aggggacagg agccucuugc a 31
<210> 472
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 472
agagacccca ggggacagga gccucuugca g 31
<210> 473
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 473
ggggugggag aggcgaggaa gucaccauca a 31
<210> 474
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 474
aaugcauggg gugggagagg cgaggaaguc a 31
<210> 475
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 475
gggugggaga ggcgaggaag ucaccaucaa a 31
<210> 476
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 476
aucaaaccac uuuaucuaca guuagcauaa g 31
<210> 477
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 477
ucaaaccacu uuaucuacag uuagcauaag a 31
<210> 478
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 478
caaaccacuu uaucuacagu uagcauaaga u 31
<210> 479
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 479
uuuaucuaca guuagcauaa gaugugagaa g 31
<210> 480
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 480
uuaucuacag uuagcauaag augugagaag u 31
<210> 481
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 481
ugcauggggu gggagaggcg aggaagucac c 31
<210> 482
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 482
gagaccccag gggacaggag ccucuugcag u 31
<210> 483
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 483
agaccccagg ggacaggagc cucuugcagu c 31
<210> 484
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 484
caggagccuc uugcagucug ucccuaggcc c 31
<210> 485
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 485
ggagccucuu gcagucuguc ccuaggccca g 31
<210> 486
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 486
gagccucuug cagucugucc cuaggcccag c 31
<210> 487
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 487
agccucuugc agucuguccc uaggcccagc c 31
<210> 488
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 488
augcaugggg ugggagaggc gaggaaguca c 31
<210> 489
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 489
cauggggugg gagaggcgag gaagucacca u 31
<210> 490
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 490
augggguggg agaggcgagg aagucaccau c 31
<210> 491
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 491
ugggguggga gaggcgagga agucaccauc a 31
<210> 492
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 492
aguaacaggu gagguucuac cuuaaaauuu a 31
<210> 493
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 493
guaacaggug agguucuacc uuaaaauuua a 31
<210> 494
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 494
aaaccacuuu aucuacaguu agcauaagau g 31
<210> 495
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 495
aaccacuuua ucuacaguua gcauaagaug u 31
<210> 496
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 496
acuuuaucua caguuagcau aagaugugag a 31
<210> 497
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 497
cuuuaucuac aguuagcaua agaugugaga a 31
<210> 498
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 498
gaccccaggg gacaggagcc ucuugcaguc u 31
<210> 499
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 499
accccagggg acaggagccu cuugcagucu g 31
<210> 500
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 500
ccccagggga caggagccuc uugcagucug u 31
<210> 501
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 501
cccaggggac aggagccucu ugcagucugu c 31
<210> 502
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 502
caggggacag gagccucuug cagucugucc c 31
<210> 503
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 503
aggggacagg agccucuugc agucuguccc u 31
<210> 504
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 504
ggggacagga gccucuugca gucugucccu a 31
<210> 505
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 505
gggacaggag ccucuugcag ucugucccua g 31
<210> 506
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 506
aggagccucu ugcagucugu cccuaggccc a 31
<210> 507
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 507
ucaguaacag gugagguucu accuuaaaau u 31
<210> 508
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 508
caguaacagg ugagguucua ccuuaaaauu u 31
<210> 509
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 509
accacuuuau cuacaguuag cauaagaugu g 31
<210> 510
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 510
ccacuuuauc uacaguuagc auaagaugug a 31
<210> 511
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 511
cacuuuaucu acaguuagca uaagauguga g 31
<210> 512
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 512
ggcccagccc ugcuuguccu cccuggcugu u 31
<210> 513
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 513
cacaaaugca gcagagaccc caggggacag g 31
<210> 514
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 514
caaaugcagc agagacccca ggggacagga g 31
<210> 515
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 515
aaaugcagca gagaccccag gggacaggag c 31
<210> 516
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 516
gacacaaaug cagcagagac cccaggggac a 31
<210> 517
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 517
acacaaaugc agcagagacc ccaggggaca g 31
<210> 518
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 518
acaaaugcag cagagacccc aggggacagg a 31
<210> 519
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 519
ccuaggccca gcccugcuug uccucccugg c 31
<210> 520
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 520
cugucccuag gcccagcccu gcuuguccuc c 31
<210> 521
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 521
cuaggcccag cccugcuugu ccucccuggc u 31
<210> 522
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 522
uaggcccagc ccugcuuguc cucccuggcu g 31
<210> 523
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 523
aggcccagcc cugcuugucc ucccuggcug u 31
<210> 524
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 524
gucugucccu aggcccagcc cugcuugucc u 31
<210> 525
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 525
ucugucccua ggcccagccc ugcuuguccu c 31
<210> 526
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 526
gcccagcccu gcuuguccuc ccuggcuguu a 31
<210> 527
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 527
ccagcccugc uuguccuccc uggcuguuau c 31
<210> 528
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 528
gaugacacaa augcagcaga gaccccaggg g 31
<210> 529
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 529
ugacacaaau gcagcagaga ccccagggga c 31
<210> 530
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 530
cagcccugcu uguccucccu ggcuguuauc u 31
<210> 531
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 531
uuuaaugcau ggggugggag aggcgaggaa g 31
<210> 532
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 532
uuaaugcaug gggugggaga ggcgaggaag u 31
<210> 533
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 533
agaugacaca aaugcagcag agaccccagg g 31
<210> 534
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 534
augacacaaa ugcagcagag accccagggg a 31
<210> 535
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 535
auuuaaugca ugggguggga gaggcgagga a 31
<210> 536
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 536
gccucuugca gucugucccu aggcccagcc c 31
<210> 537
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 537
ccucuugcag ucugucccua ggcccagccc u 31
<210> 538
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 538
cucuugcagu cugucccuag gcccagcccu g 31
<210> 539
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 539
ucuugcaguc ugucccuagg cccagcccug c 31
<210> 540
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 540
cuugcagucu gucccuaggc ccagcccugc u 31
<210> 541
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 541
ugcagucugu cccuaggccc agcccugcuu g 31
<210> 542
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 542
gcagucuguc ccuaggccca gcccugcuug u 31
<210> 543
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 543
cagucugucc cuaggcccag cccugcuugu c 31
<210> 544
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 544
agucuguccc uaggcccagc ccugcuuguc c 31
<210> 545
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 545
uugcagucug ucccuaggcc cagcccugcu u 31
<210> 546
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 546
uaaugcaugg ggugggagag gcgaggaagu c 31
<210> 547
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 547
ggugagguuc uaccuuaaaa uuuaaugcau g 31
<210> 548
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 548
gugagguucu accuuaaaau uuaaugcaug g 31
<210> 549
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 549
aacaggugag guucuaccuu aaaauuuaau g 31
<210> 550
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 550
aggugagguu cuaccuuaaa auuuaaugca u 31
<210> 551
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 551
uaacagguga gguucuaccu uaaaauuuaa u 31
<210> 552
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 552
acaggugagg uucuaccuua aaauuuaaug c 31
<210> 553
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 553
caggugaggu ucuaccuuaa aauuuaaugc a 31
<210> 554
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 554
cccuaggccc agcccugcuu guccucccug g 31
<210> 555
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 555
ugucccuagg cccagcccug cuuguccucc c 31
<210> 556
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 556
gucccuaggc ccagcccugc uuguccuccc u 31
<210> 557
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 557
ucccuaggcc cagcccugcu uguccucccu g 31
<210> 558
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 558
cccagcccug cuuguccucc cuggcuguua u 31
<210> 559
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 559
aaauuuaaug cauggggugg gagaggcgag g 31
<210> 560
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 560
aauuuaaugc augggguggg agaggcgagg a 31
<210> 561
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 561
aaaauuuaau gcauggggug ggagaggcga g 31
<210> 562
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 562
uaaaauuuaa ugcauggggu gggagaggcg a 31
<210> 563
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 563
gagguucuac cuuaaaauuu aaugcauggg g 31
<210> 564
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 564
gguucuaccu uaaaauuuaa ugcauggggu g 31
<210> 565
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 565
guucuaccuu aaaauuuaau gcauggggug g 31
<210> 566
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 566
ugagguucua ccuuaaaauu uaaugcaugg g 31
<210> 567
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 567
agguucuacc uuaaaauuua augcaugggg u 31
<210> 568
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 568
uuaaaauuua augcaugggg ugggagaggc g 31
<210> 569
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 569
ccuuaaaauu uaaugcaugg ggugggagag g 31
<210> 570
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 570
cuuaaaauuu aaugcauggg gugggagagg c 31
<210> 571
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 571
accuuaaaau uuaaugcaug gggugggaga g 31
<210> 572
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 572
uaccuuaaaa uuuaaugcau ggggugggag a 31
<210> 573
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 573
cuaccuuaaa auuuaaugca ugggguggga g 31
<210> 574
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 574
uucuaccuua aaauuuaaug cauggggugg g 31
<210> 575
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 575
ucuaccuuaa aauuuaaugc augggguggg a 31
<210> 576
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 576
ggccucagcg ucuguccgug gugcugaagu u 31
<210> 577
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 577
gccucagcgu cuguccgugg ugcugaaguu u 31
<210> 578
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 578
gaugaagaca ggaagcugca gcuccaggag g 31
<210> 579
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 579
agaugaagac aggaagcugc agcuccagga g 31
<210> 580
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 580
caggccucag cgucuguccg uggugcugaa g 31
<210> 581
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 581
aggccucagc gucuguccgu ggugcugaag u 31
<210> 582
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 582
ggcaaugcga ccaagcugug ugacacaccg c 31
<210> 583
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 583
gcaaugcgac caagcugugu gacacaccgc a 31
<210> 584
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 584
augcgaccaa gcugugugac acaccgcaag g 31
<210> 585
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 585
caaugcgacc aagcugugug acacaccgca a 31
<210> 586
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 586
aaugcgacca agcuguguga cacaccgcaa g 31
<210> 587
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 587
gauagaugaa gacaggaagc ugcagcucca g 31
<210> 588
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 588
auagaugaag acaggaagcu gcagcuccag g 31
<210> 589
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 589
uagaugaaga caggaagcug cagcuccagg a 31
<210> 590
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 590
gaucgugaua gaugaagaca ggaagcugca g 31
<210> 591
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 591
aucgaucgug auagaugaag acaggaagcu g 31
<210> 592
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 592
aacaucgauc gugauagaug aagacaggaa g 31
<210> 593
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 593
uaacaucgau cgugauagau gaagacagga a 31
<210> 594
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 594
ucaccaccuc ucaguggcaa ugcgaccaag c 31
<210> 595
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 595
caccaccucu caguggcaau gcgaccaagc u 31
<210> 596
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 596
accaccucuc aguggcaaug cgaccaagcu g 31
<210> 597
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 597
guggcaaugc gaccaagcug ugugacacac c 31
<210> 598
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 598
uggcaaugcg accaagcugu gugacacacc g 31
<210> 599
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 599
caguggcaau gcgaccaagc ugugugacac a 31
<210> 600
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 600
aguggcaaug cgaccaagcu gugugacaca c 31
<210> 601
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 601
cgugauagau gaagacagga agcugcagcu c 31
<210> 602
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 602
gugauagaug aagacaggaa gcugcagcuc c 31
<210> 603
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 603
auucaccacc ucucaguggc aaugcgacca a 31
<210> 604
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 604
ucgaucguga uagaugaaga caggaagcug c 31
<210> 605
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 605
cgaucgugau agaugaagac aggaagcugc a 31
<210> 606
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 606
aucgugauag augaagacag gaagcugcag c 31
<210> 607
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 607
ucgugauaga ugaagacagg aagcugcagc u 31
<210> 608
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 608
ugauagauga agacaggaag cugcagcucc a 31
<210> 609
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 609
acaucgaucg ugauagauga agacaggaag c 31
<210> 610
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 610
caucgaucgu gauagaugaa gacaggaagc u 31
<210> 611
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 611
ccaccucuca guggcaaugc gaccaagcug u 31
<210> 612
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 612
caccucucag uggcaaugcg accaagcugu g 31
<210> 613
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 613
ccucucagug gcaaugcgac caagcugugu g 31
<210> 614
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 614
uucaccaccu cucaguggca augcgaccaa g 31
<210> 615
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 615
cucaguggca augcgaccaa gcugugugac a 31
<210> 616
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 616
ucaguggcaa ugcgaccaag cugugugaca c 31
<210> 617
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 617
accucucagu ggcaaugcga ccaagcugug u 31
<210> 618
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 618
cucucagugg caaugcgacc aagcugugug a 31
<210> 619
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 619
ucucaguggc aaugcgacca agcuguguga c 31
<210> 620
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 620
uaaggccuca cuaaaccacu caucuacacu u 31
<210> 621
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 621
aaggccucac uaaaccacuc aucuacacuu a 31
<210> 622
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 622
aaaccacuca ucuacacuua acaucgaucg u 31
<210> 623
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 623
gcgaccaagc ugugugacac accgcaaggg c 31
<210> 624
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 624
augaagacag gaagcugcag cuccaggagg g 31
<210> 625
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 625
gaagacagga agcugcagcu ccaggagggu a 31
<210> 626
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 626
gcgucugucc guggugcuga aguuuauucg g 31
<210> 627
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 627
guaaggccuc acuaaaccac ucaucuacac u 31
<210> 628
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 628
aaccacucau cuacacuuaa caucgaucgu g 31
<210> 629
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 629
accacucauc uacacuuaac aucgaucgug a 31
<210> 630
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 630
ccacucaucu acacuuaaca ucgaucguga u 31
<210> 631
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 631
cacucaucua cacuuaacau cgaucgugau a 31
<210> 632
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 632
ugcgaccaag cugugugaca caccgcaagg g 31
<210> 633
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 633
cgaccaagcu gugugacaca ccgcaagggc u 31
<210> 634
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 634
ugaagacagg aagcugcagc uccaggaggg u 31
<210> 635
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 635
ccucagcguc uguccguggu gcugaaguuu a 31
<210> 636
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 636
aagacaggaa gcugcagcuc caggagggua u 31
<210> 637
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 637
cucagcgucu guccguggug cugaaguuua u 31
<210> 638
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 638
cagcgucugu ccguggugcu gaaguuuauu c 31
<210> 639
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 639
agcgucuguc cguggugcug aaguuuauuc g 31
<210> 640
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 640
cgucuguccg uggugcugaa guuuauucgg a 31
<210> 641
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 641
ucagcgucug uccguggugc ugaaguuuau u 31
<210> 642
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 642
gucuguccgu ggugcugaag uuuauucgga u 31
<210> 643
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 643
gguaaggccu cacuaaacca cucaucuaca c 31
<210> 644
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 644
ucuguccgug gugcugaagu uuauucggau u 31
<210> 645
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 645
agguaaggcc ucacuaaacc acucaucuac a 31
<210> 646
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 646
acucaucuac acuuaacauc gaucgugaua g 31
<210> 647
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 647
cucaucuaca cuuaacaucg aucgugauag a 31
<210> 648
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 648
uuaacaucga ucgugauaga ugaagacagg a 31
<210> 649
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 649
ucaucuacac uuaacaucga ucgugauaga u 31
<210> 650
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 650
ccaagcugug ugacacaccg caagggcuug g 31
<210> 651
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 651
gaccaagcug ugugacacac cgcaagggcu u 31
<210> 652
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 652
accaagcugu gugacacacc gcaagggcuu g 31
<210> 653
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 653
uaugcagagu gggagaggua aggccucacu a 31
<210> 654
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 654
augcagagug ggagagguaa ggccucacua a 31
<210> 655
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 655
ggagagguaa ggccucacua aaccacucau c 31
<210> 656
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 656
uauucaccac cucucagugg caaugcgacc a 31
<210> 657
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 657
gagguaaggc cucacuaaac cacucaucua c 31
<210> 658
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 658
uuuccaacug cuuucugaaa ggggugagga u 31
<210> 659
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 659
ugcuuucuga aaggggugag gaucuaccuu a 31
<210> 660
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 660
agagguaagg ccucacuaaa ccacucaucu a 31
<210> 661
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 661
cuuaacaucg aucgugauag augaagacag g 31
<210> 662
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 662
caucuacacu uaacaucgau cgugauagau g 31
<210> 663
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 663
acuuaacauc gaucgugaua gaugaagaca g 31
<210> 664
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 664
aucuacacuu aacaucgauc gugauagaug a 31
<210> 665
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 665
ucuacacuua acaucgaucg ugauagauga a 31
<210> 666
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 666
uacacuuaac aucgaucgug auagaugaag a 31
<210> 667
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 667
guauucacca ccucucagug gcaaugcgac c 31
<210> 668
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 668
uuccaacugc uuucugaaag gggugaggau c 31
<210> 669
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 669
uccaacugcu uucugaaagg ggugaggauc u 31
<210> 670
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 670
ccaacugcuu ucugaaaggg gugaggaucu a 31
<210> 671
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 671
caacugcuuu cugaaagggg ugaggaucua c 31
<210> 672
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 672
aacugcuuuc ugaaaggggu gaggaucuac c 31
<210> 673
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 673
acugcuuucu gaaaggggug aggaucuacc u 31
<210> 674
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 674
cugcuuucug aaagggguga ggaucuaccu u 31
<210> 675
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 675
gagagguaag gccucacuaa accacucauc u 31
<210> 676
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 676
cuacacuuaa caucgaucgu gauagaugaa g 31
<210> 677
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 677
acacuuaaca ucgaucguga uagaugaaga c 31
<210> 678
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 678
cacuuaacau cgaucgugau agaugaagac a 31
<210> 679
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 679
gguauucacc accucucagu ggcaaugcga c 31
<210> 680
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 680
ccucacuaaa ccacucaucu acacuuaaca u 31
<210> 681
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 681
cucacuaaac cacucaucua cacuuaacau c 31
<210> 682
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 682
gccucacuaa accacucauc uacacuuaac a 31
<210> 683
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 683
ucacuaaacc acucaucuac acuuaacauc g 31
<210> 684
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 684
cacuaaacca cucaucuaca cuuaacaucg a 31
<210> 685
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 685
cuaaaccacu caucuacacu uaacaucgau c 31
<210> 686
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 686
acuaaaccac ucaucuacac uuaacaucga u 31
<210> 687
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 687
ggccucacua aaccacucau cuacacuuaa c 31
<210> 688
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 688
aggccucacu aaaccacuca ucuacacuua a 31
<210> 689
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 689
uaaaccacuc aucuacacuu aacaucgauc g 31
<210> 690
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 690
uaccuuaaua ugcagagugg gagagguaag g 31
<210> 691
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 691
gcagaguggg agagguaagg ccucacuaaa c 31
<210> 692
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 692
cagaguggga gagguaaggc cucacuaaac c 31
<210> 693
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 693
gagugggaga gguaaggccu cacuaaacca c 31
<210> 694
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 694
ggcuugggau cuuuugcgau cugcucgagc a 31
<210> 695
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 695
gcuugggauc uuuugcgauc ugcucgagca g 31
<210> 696
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 696
agagugggag agguaaggcc ucacuaaacc a 31
<210> 697
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 697
cuuuugcgau cugcucgagc agauuuggcu g 31
<210> 698
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 698
ggggugagga ucuaccuuaa uaugcagagu g 31
<210> 699
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 699
gggugaggau cuaccuuaau augcagagug g 31
<210> 700
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 700
ggugaggauc uaccuuaaua ugcagagugg g 31
<210> 701
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 701
ggaucuaccu uaauaugcag agugggagag g 31
<210> 702
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 702
accuuaauau gcagaguggg agagguaagg c 31
<210> 703
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 703
cuuaauaugc agagugggag agguaaggcc u 31
<210> 704
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 704
uuaauaugca gagugggaga gguaaggccu c 31
<210> 705
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 705
uaauaugcag agugggagag guaaggccuc a 31
<210> 706
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 706
ucuuuugcga ucugcucgag cagauuuggc u 31
<210> 707
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 707
cuguccgugg ugcugaaguu uauucggauu u 31
<210> 708
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 708
gaaaggggug aggaucuacc uuaauaugca g 31
<210> 709
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 709
aaggggugag gaucuaccuu aauaugcaga g 31
<210> 710
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 710
aggggugagg aucuaccuua auaugcagag u 31
<210> 711
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 711
gugaggaucu accuuaauau gcagaguggg a 31
<210> 712
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 712
ugaggaucua ccuuaauaug cagaguggga g 31
<210> 713
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 713
gaggaucuac cuuaauaugc agagugggag a 31
<210> 714
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 714
aggaucuacc uuaauaugca gagugggaga g 31
<210> 715
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 715
gaucuaccuu aauaugcaga gugggagagg u 31
<210> 716
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 716
cuaccuuaau augcagagug ggagagguaa g 31
<210> 717
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 717
uguccguggu gcugaaguuu auucggauuu a 31
<210> 718
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 718
guccguggug cugaaguuua uucggauuua u 31
<210> 719
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 719
ucugaaaggg gugaggaucu accuuaauau g 31
<210> 720
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 720
ugaaaggggu gaggaucuac cuuaauaugc a 31
<210> 721
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 721
aaagggguga ggaucuaccu uaauaugcag a 31
<210> 722
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 722
aucuaccuua auaugcagag ugggagaggu a 31
<210> 723
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 723
ucuaccuuaa uaugcagagu gggagaggua a 31
<210> 724
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 724
uccguggugc ugaaguuuau ucggauuuau u 31
<210> 725
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 725
uuucugaaag gggugaggau cuaccuuaau a 31
<210> 726
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 726
uucugaaagg ggugaggauc uaccuuaaua u 31
<210> 727
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 727
caagcugugu gacacaccgc aagggcuugg g 31
<210> 728
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 728
gacaggaagc ugcagcucca ggaggguauu c 31
<210> 729
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 729
caggaagcug cagcuccagg aggguauuca c 31
<210> 730
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 730
aggaagcugc agcuccagga ggguauucac c 31
<210> 731
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 731
ggaagcugca gcuccaggag gguauucacc a 31
<210> 732
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 732
gaagcugcag cuccaggagg guauucacca c 31
<210> 733
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 733
aagcugcagc uccaggaggg uauucaccac c 31
<210> 734
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 734
aagcugugug acacaccgca agggcuuggg a 31
<210> 735
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 735
gugggagagg uaaggccuca cuaaaccacu c 31
<210> 736
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 736
agacaggaag cugcagcucc aggaggguau u 31
<210> 737
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 737
acaggaagcu gcagcuccag gaggguauuc a 31
<210> 738
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 738
ccuuaauaug cagaguggga gagguaaggc c 31
<210> 739
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 739
aauaugcaga gugggagagg uaaggccuca c 31
<210> 740
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 740
auaugcagag ugggagaggu aaggccucac u 31
<210> 741
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 741
ugcagagugg gagagguaag gccucacuaa a 31
<210> 742
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 742
agugggagag guaaggccuc acuaaaccac u 31
<210> 743
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 743
ugggagaggu aaggccucac uaaaccacuc a 31
<210> 744
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 744
gggagaggua aggccucacu aaaccacuca u 31
<210> 745
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 745
cuugggaucu uuugcgaucu gcucgagcag a 31
<210> 746
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 746
uugggaucuu uugcgaucug cucgagcaga u 31
<210> 747
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 747
ugggaucuuu ugcgaucugc ucgagcagau u 31
<210> 748
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 748
ggaucuuuug cgaucugcuc gagcagauuu g 31
<210> 749
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 749
gaucuuuugc gaucugcucg agcagauuug g 31
<210> 750
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 750
aucuuuugcg aucugcucga gcagauuugg c 31
<210> 751
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 751
uuuuuccaac ugcuuucuga aaggggugag g 31
<210> 752
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 752
uuuuccaacu gcuuucugaa aggggugagg a 31
<210> 753
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 753
gcuuucugaa aggggugagg aucuaccuua a 31
<210> 754
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 754
cugaaagggg ugaggaucua ccuuaauaug c 31
<210> 755
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 755
uuuuuuccaa cugcuuucug aaagggguga g 31
<210> 756
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 756
cuuucugaaa ggggugagga ucuaccuuaa u 31
<210> 757
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 757
uuuuuuucca acugcuuucu gaaaggggug a 31
<210> 758
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 758
gcugcagcuc caggagggua uucaccaccu c 31
<210> 759
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 759
gcugugugac acaccgcaag ggcuugggau c 31
<210> 760
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 760
agcugcagcu ccaggagggu auucaccacc u 31
<210> 761
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 761
cugcagcucc aggaggguau ucaccaccuc u 31
<210> 762
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 762
ugcagcucca ggaggguauu caccaccucu c 31
<210> 763
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 763
gcagcuccag gaggguauuc accaccucuc a 31
<210> 764
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 764
cagcuccagg aggguauuca ccaccucuca g 31
<210> 765
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 765
gcuccaggag gguauucacc accucucagu g 31
<210> 766
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 766
cuccaggagg guauucacca ccucucagug g 31
<210> 767
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 767
uccaggaggg uauucaccac cucucagugg c 31
<210> 768
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 768
ccaggagggu auucaccacc ucucaguggc a 31
<210> 769
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 769
agcuguguga cacaccgcaa gggcuuggga u 31
<210> 770
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 770
cugugugaca caccgcaagg gcuugggauc u 31
<210> 771
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 771
caggagggua uucaccaccu cucaguggca a 31
<210> 772
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 772
ugugugacac accgcaaggg cuugggaucu u 31
<210> 773
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 773
gugugacaca ccgcaagggc uugggaucuu u 31
<210> 774
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 774
agcuccagga ggguauucac caccucucag u 31
<210> 775
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 775
ggaggguauu caccaccucu caguggcaau g 31
<210> 776
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 776
gaggguauuc accaccucuc aguggcaaug c 31
<210> 777
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 777
aggguauuca ccaccucuca guggcaaugc g 31
<210> 778
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 778
ggguauucac caccucucag uggcaaugcg a 31
<210> 779
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 779
aggaggguau ucaccaccuc ucaguggcaa u 31
<210> 780
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 780
guggugcuga aguuuauucg gauuuauuuu u 31
<210> 781
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 781
uggugcugaa guuuauucgg auuuauuuuu u 31
<210> 782
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 782
gggcuuggga ucuuuugcga ucugcucgag c 31
<210> 783
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 783
cguggugcug aaguuuauuc ggauuuauuu u 31
<210> 784
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 784
auucggauuu auuuuuuucc aacugcuuuc u 31
<210> 785
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 785
ccgcaagggc uugggaucuu uugcgaucug c 31
<210> 786
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 786
cgcaagggcu ugggaucuuu ugcgaucugc u 31
<210> 787
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 787
gcaagggcuu gggaucuuuu gcgaucugcu c 31
<210> 788
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 788
caagggcuug ggaucuuuug cgaucugcuc g 31
<210> 789
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 789
agggcuuggg aucuuuugcg aucugcucga g 31
<210> 790
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 790
ccguggugcu gaaguuuauu cggauuuauu u 31
<210> 791
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 791
uucggauuua uuuuuuucca acugcuuucu g 31
<210> 792
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 792
ucggauuuau uuuuuuccaa cugcuuucug a 31
<210> 793
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 793
cggauuuauu uuuuuccaac ugcuuucuga a 31
<210> 794
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 794
ggauuuauuu uuuuccaacu gcuuucugaa a 31
<210> 795
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 795
gauuuauuuu uuuccaacug cuuucugaaa g 31
<210> 796
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 796
auuuauuuuu uuccaacugc uuucugaaag g 31
<210> 797
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 797
caccgcaagg gcuugggauc uuuugcgauc u 31
<210> 798
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 798
accgcaaggg cuugggaucu uuugcgaucu g 31
<210> 799
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 799
aagggcuugg gaucuuuugc gaucugcucg a 31
<210> 800
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 800
gggaucuuuu gcgaucugcu cgagcagauu u 31
<210> 801
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 801
auuuuuuucc aacugcuuuc ugaaaggggu g 31
<210> 802
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 802
uuauuuuuuu ccaacugcuu ucugaaaggg g 31
<210> 803
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 803
uauuuuuuuc caacugcuuu cugaaagggg u 31
<210> 804
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 804
uuuauuuuuu uccaacugcu uucugaaagg g 31
<210> 805
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 805
gacacaccgc aagggcuugg gaucuuuugc g 31
<210> 806
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 806
gugacacacc gcaagggcuu gggaucuuuu g 31
<210> 807
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 807
ugacacaccg caagggcuug ggaucuuuug c 31
<210> 808
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 808
cacaccgcaa gggcuuggga ucuuuugcga u 31
<210> 809
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 809
acaccgcaag ggcuugggau cuuuugcgau c 31
<210> 810
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 810
ugugacacac cgcaagggcu ugggaucuuu u 31
<210> 811
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 811
acacaccgca agggcuuggg aucuuuugcg a 31
<210> 812
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 812
ggugcugaag uuuauucgga uuuauuuuuu u 31
<210> 813
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 813
gugcugaagu uuauucggau uuauuuuuuu c 31
<210> 814
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 814
uauucggauu uauuuuuuuc caacugcuuu c 31
<210> 815
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 815
uuuauucgga uuuauuuuuu uccaacugcu u 31
<210> 816
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 816
uuauucggau uuauuuuuuu ccaacugcuu u 31
<210> 817
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 817
ugcugaaguu uauucggauu uauuuuuuuc c 31
<210> 818
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 818
gcugaaguuu auucggauuu auuuuuuucc a 31
<210> 819
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 819
aguuuauucg gauuuauuuu uuuccaacug c 31
<210> 820
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 820
guuuauucgg auuuauuuuu uuccaacugc u 31
<210> 821
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 821
cugaaguuua uucggauuua uuuuuuucca a 31
<210> 822
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 822
ugaaguuuau ucggauuuau uuuuuuccaa c 31
<210> 823
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 823
gaaguuuauu cggauuuauu uuuuuccaac u 31
<210> 824
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 824
aaguuuauuc ggauuuauuu uuuuccaacu g 31
<210> 825
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 825
ggaaucagaa gcaggugucu gcagccagga c 31
<210> 826
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 826
guggaaucag aagcaggugu cugcagccag g 31
<210> 827
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 827
uggaaucaga agcagguguc ugcagccagg a 31
<210> 828
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 828
gaaucagaag caggugucug cagccaggac u 31
<210> 829
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 829
ucagaagcag gugucugcag ccaggacuuc c 31
<210> 830
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 830
cagaagcagg ugucugcagc caggacuucc u 31
<210> 831
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 831
agaagcaggu gucugcagcc aggacuuccu c 31
<210> 832
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 832
uguggaauca gaagcaggug ucugcagcca g 31
<210> 833
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 833
aucagaagca ggugucugca gccaggacuu c 31
<210> 834
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 834
uuguggaauc agaagcaggu gucugcagcc a 31
<210> 835
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 835
aaucagaagc aggugucugc agccaggacu u 31
<210> 836
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 836
ccuuguggaa ucagaagcag gugucugcag c 31
<210> 837
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 837
cuuguggaau cagaagcagg ugucugcagc c 31
<210> 838
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 838
cacuucaaag gcggccacag gguugaggaa a 31
<210> 839
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 839
aaaaaugagu cacuucaaag gcggccacag g 31
<210> 840
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 840
aaaaaaugag ucacuucaaa ggcggccaca g 31
<210> 841
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 841
accguggaaa uuuugugcuc aaagguaaga a 31
<210> 842
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 842
ccguggaaau uuugugcuca aagguaagaa a 31
<210> 843
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 843
cguggaaauu uugugcucaa agguaagaaa c 31
<210> 844
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 844
guggaaauuu ugugcucaaa gguaagaaac c 31
<210> 845
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 845
uggaaauuuu gugcucaaag guaagaaacc a 31
<210> 846
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 846
ggaaauuuug ugcucaaagg uaagaaacca u 31
<210> 847
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 847
gagucacuuc aaaggcggcc acaggguuga g 31
<210> 848
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 848
agucacuuca aaggcggcca caggguugag g 31
<210> 849
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 849
gucacuucaa aggcggccac aggguugagg a 31
<210> 850
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 850
ucacuucaaa ggcggccaca ggguugagga a 31
<210> 851
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 851
ucaccgugga aauuuugugc ucaaagguaa g 31
<210> 852
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 852
caccguggaa auuuugugcu caaagguaag a 31
<210> 853
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 853
uuucaccgug gaaauuuugu gcucaaaggu a 31
<210> 854
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 854
uucaccgugg aaauuuugug cucaaaggua a 31
<210> 855
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 855
gaaauuuugu gcucaaaggu aagaaaccau c 31
<210> 856
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 856
aaauuuugug cucaaaggua agaaaccauc u 31
<210> 857
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 857
aauuuugugc ucaaagguaa gaaaccaucu u 31
<210> 858
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 858
auuuugugcu caaagguaag aaaccaucuu a 31
<210> 859
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 859
uuugugcuca aagguaagaa accaucuuau a 31
<210> 860
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 860
uugugcucaa agguaagaaa ccaucuuaua u 31
<210> 861
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 861
ugugcucaaa gguaagaaac caucuuauau a 31
<210> 862
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 862
gccccuugug gaaucagaag caggugucug c 31
<210> 863
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 863
augagucacu ucaaaggcgg ccacaggguu g 31
<210> 864
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 864
ugagucacuu caaaggcggc cacaggguug a 31
<210> 865
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 865
aaugagucac uucaaaggcg gccacagggu u 31
<210> 866
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 866
aaagccccuu guggaaucag aagcaggugu c 31
<210> 867
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 867
agccccuugu ggaaucagaa gcaggugucu g 31
<210> 868
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 868
ccccuugugg aaucagaagc aggugucugc a 31
<210> 869
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 869
cccuugugga aucagaagca ggugucugca g 31
<210> 870
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 870
aagccccuug uggaaucaga agcagguguc u 31
<210> 871
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 871
caaaggcggc cacaggguug aggaaaaagc c 31
<210> 872
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 872
guaagaaacc aucuuauaua aaacaaucaa a 31
<210> 873
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 873
ucaaaggcgg ccacaggguu gaggaaaaag c 31
<210> 874
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 874
cucaaaggua agaaaccauc uuauauaaaa c 31
<210> 875
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 875
ucaaagguaa gaaaccaucu uauauaaaac a 31
<210> 876
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 876
caaagguaag aaaccaucuu auauaaaaca a 31
<210> 877
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 877
aagguaagaa accaucuuau auaaaacaau c 31
<210> 878
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 878
agguaagaaa ccaucuuaua uaaaacaauc a 31
<210> 879
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 879
gguaagaaac caucuuauau aaaacaauca a 31
<210> 880
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 880
aaagguaaga aaccaucuua uauaaaacaa u 31
<210> 881
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 881
aaaaugaguc acuucaaagg cggccacagg g 31
<210> 882
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 882
acuucaaagg cggccacagg guugaggaaa a 31
<210> 883
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 883
cuucaaaggc ggccacaggg uugaggaaaa a 31
<210> 884
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 884
uucaaaggcg gccacagggu ugaggaaaaa g 31
<210> 885
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 885
ggaaaaagcc ccuuguggaa ucagaagcag g 31
<210> 886
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 886
gaggaaaaag ccccuugugg aaucagaagc a 31
<210> 887
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 887
aggaaaaagc cccuugugga aucagaagca g 31
<210> 888
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 888
aaaaaaauga gucacuucaa aggcggccac a 31
<210> 889
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 889
guugacuuua uuucaccgug gaaauuuugu g 31
<210> 890
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 890
auguugacuu uauuucaccg uggaaauuuu g 31
<210> 891
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 891
uguugacuuu auuucaccgu ggaaauuuug u 31
<210> 892
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 892
aaagcuuaua auguugacuu uauuucaccg u 31
<210> 893
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 893
uuauaauguu gacuuuauuu caccguggaa a 31
<210> 894
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 894
aauguugacu uuauuucacc guggaaauuu u 31
<210> 895
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 895
ugcucaaagg uaagaaacca ucuuauauaa a 31
<210> 896
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 896
gcucaaaggu aagaaaccau cuuauauaaa a 31
<210> 897
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 897
auacauuaaa aaaaugaguc acuucaaagg c 31
<210> 898
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 898
aaaugaguca cuucaaaggc ggccacaggg u 31
<210> 899
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 899
gguugaggaa aaagccccuu guggaaucag a 31
<210> 900
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 900
ugaggaaaaa gccccuugug gaaucagaag c 31
<210> 901
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 901
gaaaaagccc cuuguggaau cagaagcagg u 31
<210> 902
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 902
aaaaagcccc uuguggaauc agaagcaggu g 31
<210> 903
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 903
guugaggaaa aagccccuug uggaaucaga a 31
<210> 904
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 904
uugaggaaaa agccccuugu ggaaucagaa g 31
<210> 905
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 905
uaaaaaaaug agucacuuca aaggcggcca c 31
<210> 906
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 906
uauuucaccg uggaaauuuu gugcucaaag g 31
<210> 907
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 907
auuucaccgu ggaaauuuug ugcucaaagg u 31
<210> 908
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 908
agcuuauaau guugacuuua uuucaccgug g 31
<210> 909
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 909
gcuuauaaug uugacuuuau uucaccgugg a 31
<210> 910
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 910
uugacuuuau uucaccgugg aaauuuugug c 31
<210> 911
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 911
ugacuuuauu ucaccgugga aauuuugugc u 31
<210> 912
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 912
acuuuauuuc accguggaaa uuuugugcuc a 31
<210> 913
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 913
cuuuauuuca ccguggaaau uuugugcuca a 31
<210> 914
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 914
uuauuucacc guggaaauuu ugugcucaaa g 31
<210> 915
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 915
acauuaaaaa aaugagucac uucaaaggcg g 31
<210> 916
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 916
aagcuuauaa uguugacuuu auuucaccgu g 31
<210> 917
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 917
cuuauaaugu ugacuuuauu ucaccgugga a 31
<210> 918
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 918
uuuauuucac cguggaaauu uugugcucaa a 31
<210> 919
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 919
uuuugugcuc aaagguaaga aaccaucuua u 31
<210> 920
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 920
gugcucaaag guaagaaacc aucuuauaua a 31
<210> 921
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 921
uacauuaaaa aaaugaguca cuucaaaggc g 31
<210> 922
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 922
aaaagccccu uguggaauca gaagcaggug u 31
<210> 923
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 923
gacuuuauuu caccguggaa auuuugugcu c 31
<210> 924
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 924
cauuaaaaaa augagucacu ucaaaggcgg c 31
<210> 925
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 925
auuaaaaaaa ugagucacuu caaaggcggc c 31
<210> 926
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 926
uuaaaaaaau gagucacuuc aaaggcggcc a 31
<210> 927
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 927
uaagaaacca ucuuauauaa aacaaucaaa u 31
<210> 928
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 928
aagaaaccau cuuauauaaa acaaucaaau a 31
<210> 929
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 929
agaaaccauc uuauauaaaa caaucaaaua a 31
<210> 930
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 930
gaaaccaucu uauauaaaac aaucaaauaa a 31
<210> 931
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 931
aaggcggcca caggguugag gaaaaagccc c 31
<210> 932
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 932
aaaggcggcc acaggguuga ggaaaaagcc c 31
<210> 933
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 933
acauaaauac auuaaaaaaa ugagucacuu c 31
<210> 934
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 934
cauaaauaca uuaaaaaaau gagucacuuc a 31
<210> 935
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 935
auacauaaau acauuaaaaa aaugagucac u 31
<210> 936
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 936
uacauaaaua cauuaaaaaa augagucacu u 31
<210> 937
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 937
auaaauacau uaaaaaaaug agucacuuca a 31
<210> 938
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 938
uaaauacauu aaaaaaauga gucacuucaa a 31
<210> 939
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 939
aggcggccac aggguugagg aaaaagcccc u 31
<210> 940
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 940
aaauacauua aaaaaaugag ucacuucaaa g 31
<210> 941
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 941
ggcggccaca ggguugagga aaaagccccu u 31
<210> 942
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 942
gcggccacag gguugaggaa aaagccccuu g 31
<210> 943
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 943
uauaauguug acuuuauuuc accguggaaa u 31
<210> 944
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 944
auaauguuga cuuuauuuca ccguggaaau u 31
<210> 945
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 945
uaauguugac uuuauuucac cguggaaauu u 31
<210> 946
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 946
aauacauuaa aaaaaugagu cacuucaaag g 31
<210> 947
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 947
cggccacagg guugaggaaa aagccccuug u 31
<210> 948
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 948
ggccacaggg uugaggaaaa agccccuugu g 31
<210> 949
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 949
gccacagggu ugaggaaaaa gccccuugug g 31
<210> 950
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 950
ccacaggguu gaggaaaaag ccccuugugg a 31
<210> 951
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 951
cacaggguug aggaaaaagc cccuugugga a 31
<210> 952
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 952
ggguugagga aaaagccccu uguggaauca g 31
<210> 953
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 953
acaggguuga ggaaaaagcc ccuuguggaa u 31
<210> 954
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 954
aggguugagg aaaaagcccc uuguggaauc a 31
<210> 955
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 955
caggguugag gaaaaagccc cuuguggaau c 31
<210> 956
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 956
accaucuuau auaaaacaau caaauaaaua c 31
<210> 957
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 957
ccaucuuaua uaaaacaauc aaauaaauac a 31
<210> 958
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 958
aaaccaucuu auauaaaaca aucaaauaaa u 31
<210> 959
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 959
aaccaucuua uauaaaacaa ucaaauaaau a 31
<210> 960
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 960
caucuuauau aaaacaauca aauaaauaca u 31
<210> 961
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 961
aucuuauaua aaacaaucaa auaaauacau a 31
<210> 962
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 962
uauaaaacaa ucaaauaaau acauaaauac a 31
<210> 963
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 963
auaaaacaau caaauaaaua cauaaauaca u 31
<210> 964
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 964
uaaaacaauc aaauaaauac auaaauacau u 31
<210> 965
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 965
aaacaaucaa auaaauacau aaauacauua a 31
<210> 966
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 966
aacaaucaaa uaaauacaua aauacauuaa a 31
<210> 967
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 967
acaaucaaau aaauacauaa auacauuaaa a 31
<210> 968
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 968
aauacauaaa uacauuaaaa aaaugaguca c 31
<210> 969
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 969
uaaauacaua aauacauuaa aaaaaugagu c 31
<210> 970
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 970
aaauacauaa auacauuaaa aaaaugaguc a 31
<210> 971
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 971
auaaauacau aaauacauua aaaaaaugag u 31
<210> 972
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 972
ucuuauauaa aacaaucaaa uaaauacaua a 31
<210> 973
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 973
cuuauauaaa acaaucaaau aaauacauaa a 31
<210> 974
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 974
auauaaaaca aucaaauaaa uacauaaaua c 31
<210> 975
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 975
aaaacaauca aauaaauaca uaaauacauu a 31
<210> 976
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 976
caaucaaaua aauacauaaa uacauuaaaa a 31
<210> 977
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 977
uuauauaaaa caaucaaaua aauacauaaa u 31
<210> 978
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 978
uauauaaaac aaucaaauaa auacauaaau a 31
<210> 979
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 979
aaucaaauaa auacauaaau acauuaaaaa a 31
<210> 980
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 980
aucaaauaaa uacauaaaua cauuaaaaaa a 31
<210> 981
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 981
ucaaauaaau acauaaauac auuaaaaaaa u 31
<210> 982
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 982
caaauaaaua cauaaauaca uuaaaaaaau g 31
<210> 983
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 983
aaauaaauac auaaauacau uaaaaaaaug a 31
<210> 984
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 984
aauaaauaca uaaauacauu aaaaaaauga g 31
<210> 985
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 985
ggccucagcg ucuguccgug gugcugaagu u 31
<210> 986
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 986
gccucagcgu cuguccgugg ugcugaaguu u 31
<210> 987
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 987
gaugaagaca ggaagcugca gcuccaggag g 31
<210> 988
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 988
agaugaagac aggaagcugc agcuccagga g 31
<210> 989
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 989
caggccucag cgucuguccg uggugcugaa g 31
<210> 990
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 990
aggccucagc gucuguccgu ggugcugaag u 31
<210> 991
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 991
ggcaaugcga ccaagcugug ugacacaccg c 31
<210> 992
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 992
gcaaugcgac caagcugugu gacacaccgc a 31
<210> 993
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 993
augcgaccaa gcugugugac acaccgcaag g 31
<210> 994
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 994
caaugcgacc aagcugugug acacaccgca a 31
<210> 995
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 995
aaugcgacca agcuguguga cacaccgcaa g 31
<210> 996
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 996
gauagaugaa gacaggaagc ugcagcucca g 31
<210> 997
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 997
auagaugaag acaggaagcu gcagcuccag g 31
<210> 998
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 998
uagaugaaga caggaagcug cagcuccagg a 31
<210> 999
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 999
gaucgugaua gaugaagaca ggaagcugca g 31
<210> 1000
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1000
aucgaucgug auagaugaag acaggaagcu g 31
<210> 1001
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1001
aacaucgauc gugauagaug aagacaggaa g 31
<210> 1002
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1002
uaacaucgau cgugauagau gaagacagga a 31
<210> 1003
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1003
ucaccaccuc ucaguggcaa ugcgaccaag c 31
<210> 1004
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1004
caccaccucu caguggcaau gcgaccaagc u 31
<210> 1005
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1005
accaccucuc aguggcaaug cgaccaagcu g 31
<210> 1006
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1006
guggcaaugc gaccaagcug ugugacacac c 31
<210> 1007
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1007
uggcaaugcg accaagcugu gugacacacc g 31
<210> 1008
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1008
caguggcaau gcgaccaagc ugugugacac a 31
<210> 1009
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1009
aguggcaaug cgaccaagcu gugugacaca c 31
<210> 1010
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1010
cgugauagau gaagacagga agcugcagcu c 31
<210> 1011
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1011
gugauagaug aagacaggaa gcugcagcuc c 31
<210> 1012
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1012
auucaccacc ucucaguggc aaugcgacca a 31
<210> 1013
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1013
ucgaucguga uagaugaaga caggaagcug c 31
<210> 1014
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1014
cgaucgugau agaugaagac aggaagcugc a 31
<210> 1015
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1015
aucgugauag augaagacag gaagcugcag c 31
<210> 1016
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1016
ucgugauaga ugaagacagg aagcugcagc u 31
<210> 1017
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1017
ugauagauga agacaggaag cugcagcucc a 31
<210> 1018
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1018
acaucgaucg ugauagauga agacaggaag c 31
<210> 1019
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1019
caucgaucgu gauagaugaa gacaggaagc u 31
<210> 1020
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1020
ccaccucuca guggcaaugc gaccaagcug u 31
<210> 1021
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1021
caccucucag uggcaaugcg accaagcugu g 31
<210> 1022
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1022
ccucucagug gcaaugcgac caagcugugu g 31
<210> 1023
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1023
uucaccaccu cucaguggca augcgaccaa g 31
<210> 1024
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1024
cucaguggca augcgaccaa gcugugugac a 31
<210> 1025
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1025
ucaguggcaa ugcgaccaag cugugugaca c 31
<210> 1026
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1026
accucucagu ggcaaugcga ccaagcugug u 31
<210> 1027
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1027
cucucagugg caaugcgacc aagcugugug a 31
<210> 1028
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1028
ucucaguggc aaugcgacca agcuguguga c 31
<210> 1029
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1029
uaaggccuca cuaaaccacu caucuacacu u 31
<210> 1030
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1030
aaggccucac uaaaccacuc aucuacacuu a 31
<210> 1031
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1031
aaaccacuca ucuacacuua acaucgaucg u 31
<210> 1032
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1032
gcgaccaagc ugugugacac accgcaaggg c 31
<210> 1033
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1033
augaagacag gaagcugcag cuccaggagg g 31
<210> 1034
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1034
gaagacagga agcugcagcu ccaggagggu a 31
<210> 1035
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1035
gcgucugucc guggugcuga aguuuauucg g 31
<210> 1036
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1036
guaaggccuc acuaaaccac ucaucuacac u 31
<210> 1037
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1037
aaccacucau cuacacuuaa caucgaucgu g 31
<210> 1038
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1038
accacucauc uacacuuaac aucgaucgug a 31
<210> 1039
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1039
ccacucaucu acacuuaaca ucgaucguga u 31
<210> 1040
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1040
cacucaucua cacuuaacau cgaucgugau a 31
<210> 1041
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1041
ugcgaccaag cugugugaca caccgcaagg g 31
<210> 1042
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1042
cgaccaagcu gugugacaca ccgcaagggc u 31
<210> 1043
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1043
ugaagacagg aagcugcagc uccaggaggg u 31
<210> 1044
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1044
ccucagcguc uguccguggu gcugaaguuu a 31
<210> 1045
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1045
aagacaggaa gcugcagcuc caggagggua u 31
<210> 1046
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1046
cucagcgucu guccguggug cugaaguuua u 31
<210> 1047
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1047
cagcgucugu ccguggugcu gaaguuuauu c 31
<210> 1048
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1048
agcgucuguc cguggugcug aaguuuauuc g 31
<210> 1049
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1049
cgucuguccg uggugcugaa guuuauucgg a 31
<210> 1050
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1050
ucagcgucug uccguggugc ugaaguuuau u 31
<210> 1051
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1051
gucuguccgu ggugcugaag uuuauucgga u 31
<210> 1052
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1052
gguaaggccu cacuaaacca cucaucuaca c 31
<210> 1053
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1053
ucuguccgug gugcugaagu uuauucggau u 31
<210> 1054
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1054
agguaaggcc ucacuaaacc acucaucuac a 31
<210> 1055
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1055
acucaucuac acuuaacauc gaucgugaua g 31
<210> 1056
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1056
cucaucuaca cuuaacaucg aucgugauag a 31
<210> 1057
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1057
uuaacaucga ucgugauaga ugaagacagg a 31
<210> 1058
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1058
ucaucuacac uuaacaucga ucgugauaga u 31
<210> 1059
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1059
ccaagcugug ugacacaccg caagggcuug g 31
<210> 1060
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1060
gaccaagcug ugugacacac cgcaagggcu u 31
<210> 1061
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1061
accaagcugu gugacacacc gcaagggcuu g 31
<210> 1062
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1062
uaugcagagu gggagaggua aggccucacu a 31
<210> 1063
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1063
augcagagug ggagagguaa ggccucacua a 31
<210> 1064
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1064
ggagagguaa ggccucacua aaccacucau c 31
<210> 1065
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1065
uauucaccac cucucagugg caaugcgacc a 31
<210> 1066
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1066
gagguaaggc cucacuaaac cacucaucua c 31
<210> 1067
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1067
uuuccaacug cuuucugaaa ggggugagga u 31
<210> 1068
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1068
ugcuuucuga aaggggugag gaucuaccuu a 31
<210> 1069
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1069
agagguaagg ccucacuaaa ccacucaucu a 31
<210> 1070
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1070
cuuaacaucg aucgugauag augaagacag g 31
<210> 1071
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1071
caucuacacu uaacaucgau cgugauagau g 31
<210> 1072
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1072
acuuaacauc gaucgugaua gaugaagaca g 31
<210> 1073
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1073
aucuacacuu aacaucgauc gugauagaug a 31
<210> 1074
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1074
ucuacacuua acaucgaucg ugauagauga a 31
<210> 1075
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1075
uacacuuaac aucgaucgug auagaugaag a 31
<210> 1076
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1076
guauucacca ccucucagug gcaaugcgac c 31
<210> 1077
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1077
uuccaacugc uuucugaaag gggugaggau c 31
<210> 1078
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1078
uccaacugcu uucugaaagg ggugaggauc u 31
<210> 1079
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1079
ccaacugcuu ucugaaaggg gugaggaucu a 31
<210> 1080
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1080
caacugcuuu cugaaagggg ugaggaucua c 31
<210> 1081
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1081
aacugcuuuc ugaaaggggu gaggaucuac c 31
<210> 1082
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1082
acugcuuucu gaaaggggug aggaucuacc u 31
<210> 1083
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1083
cugcuuucug aaagggguga ggaucuaccu u 31
<210> 1084
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1084
gagagguaag gccucacuaa accacucauc u 31
<210> 1085
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1085
cuacacuuaa caucgaucgu gauagaugaa g 31
<210> 1086
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1086
acacuuaaca ucgaucguga uagaugaaga c 31
<210> 1087
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1087
cacuuaacau cgaucgugau agaugaagac a 31
<210> 1088
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1088
gguauucacc accucucagu ggcaaugcga c 31
<210> 1089
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1089
ccucacuaaa ccacucaucu acacuuaaca u 31
<210> 1090
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1090
cucacuaaac cacucaucua cacuuaacau c 31
<210> 1091
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1091
gccucacuaa accacucauc uacacuuaac a 31
<210> 1092
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1092
ucacuaaacc acucaucuac acuuaacauc g 31
<210> 1093
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1093
cacuaaacca cucaucuaca cuuaacaucg a 31
<210> 1094
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1094
cuaaaccacu caucuacacu uaacaucgau c 31
<210> 1095
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1095
acuaaaccac ucaucuacac uuaacaucga u 31
<210> 1096
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1096
ggccucacua aaccacucau cuacacuuaa c 31
<210> 1097
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1097
aggccucacu aaaccacuca ucuacacuua a 31
<210> 1098
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1098
uaaaccacuc aucuacacuu aacaucgauc g 31
<210> 1099
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1099
uaccuuaaua ugcagagugg gagagguaag g 31
<210> 1100
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1100
gcagaguggg agagguaagg ccucacuaaa c 31
<210> 1101
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1101
cagaguggga gagguaaggc cucacuaaac c 31
<210> 1102
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1102
gagugggaga gguaaggccu cacuaaacca c 31
<210> 1103
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1103
ggcuugggau cuuuugcgau cugcucgagc a 31
<210> 1104
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1104
gcuugggauc uuuugcgauc ugcucgagca g 31
<210> 1105
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1105
agagugggag agguaaggcc ucacuaaacc a 31
<210> 1106
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1106
cuuuugcgau cugcucgagc agauuuggcu g 31
<210> 1107
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1107
ggggugagga ucuaccuuaa uaugcagagu g 31
<210> 1108
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1108
gggugaggau cuaccuuaau augcagagug g 31
<210> 1109
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1109
ggugaggauc uaccuuaaua ugcagagugg g 31
<210> 1110
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1110
ggaucuaccu uaauaugcag agugggagag g 31
<210> 1111
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1111
accuuaauau gcagaguggg agagguaagg c 31
<210> 1112
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1112
cuuaauaugc agagugggag agguaaggcc u 31
<210> 1113
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1113
uuaauaugca gagugggaga gguaaggccu c 31
<210> 1114
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1114
uaauaugcag agugggagag guaaggccuc a 31
<210> 1115
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1115
ucuuuugcga ucugcucgag cagauuuggc u 31
<210> 1116
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1116
cuguccgugg ugcugaaguu uauucggauu u 31
<210> 1117
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1117
gaaaggggug aggaucuacc uuaauaugca g 31
<210> 1118
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1118
aaggggugag gaucuaccuu aauaugcaga g 31
<210> 1119
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1119
aggggugagg aucuaccuua auaugcagag u 31
<210> 1120
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1120
gugaggaucu accuuaauau gcagaguggg a 31
<210> 1121
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1121
ugaggaucua ccuuaauaug cagaguggga g 31
<210> 1122
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1122
gaggaucuac cuuaauaugc agagugggag a 31
<210> 1123
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1123
aggaucuacc uuaauaugca gagugggaga g 31
<210> 1124
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1124
gaucuaccuu aauaugcaga gugggagagg u 31
<210> 1125
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1125
cuaccuuaau augcagagug ggagagguaa g 31
<210> 1126
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1126
uguccguggu gcugaaguuu auucggauuu a 31
<210> 1127
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1127
guccguggug cugaaguuua uucggauuua u 31
<210> 1128
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1128
ucugaaaggg gugaggaucu accuuaauau g 31
<210> 1129
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1129
ugaaaggggu gaggaucuac cuuaauaugc a 31
<210> 1130
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1130
aaagggguga ggaucuaccu uaauaugcag a 31
<210> 1131
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1131
aucuaccuua auaugcagag ugggagaggu a 31
<210> 1132
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1132
ucuaccuuaa uaugcagagu gggagaggua a 31
<210> 1133
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1133
uccguggugc ugaaguuuau ucggauuuau u 31
<210> 1134
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1134
uuucugaaag gggugaggau cuaccuuaau a 31
<210> 1135
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1135
uucugaaagg ggugaggauc uaccuuaaua u 31
<210> 1136
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1136
caagcugugu gacacaccgc aagggcuugg g 31
<210> 1137
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1137
gacaggaagc ugcagcucca ggaggguauu c 31
<210> 1138
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1138
caggaagcug cagcuccagg aggguauuca c 31
<210> 1139
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1139
aggaagcugc agcuccagga ggguauucac c 31
<210> 1140
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1140
ggaagcugca gcuccaggag gguauucacc a 31
<210> 1141
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1141
gaagcugcag cuccaggagg guauucacca c 31
<210> 1142
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1142
aagcugcagc uccaggaggg uauucaccac c 31
<210> 1143
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1143
aagcugugug acacaccgca agggcuuggg a 31
<210> 1144
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1144
gugggagagg uaaggccuca cuaaaccacu c 31
<210> 1145
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1145
agacaggaag cugcagcucc aggaggguau u 31
<210> 1146
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1146
acaggaagcu gcagcuccag gaggguauuc a 31
<210> 1147
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1147
ccuuaauaug cagaguggga gagguaaggc c 31
<210> 1148
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1148
aauaugcaga gugggagagg uaaggccuca c 31
<210> 1149
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1149
auaugcagag ugggagaggu aaggccucac u 31
<210> 1150
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1150
ugcagagugg gagagguaag gccucacuaa a 31
<210> 1151
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1151
agugggagag guaaggccuc acuaaaccac u 31
<210> 1152
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1152
ugggagaggu aaggccucac uaaaccacuc a 31
<210> 1153
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1153
gggagaggua aggccucacu aaaccacuca u 31
<210> 1154
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1154
cuugggaucu uuugcgaucu gcucgagcag a 31
<210> 1155
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1155
uugggaucuu uugcgaucug cucgagcaga u 31
<210> 1156
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1156
ugggaucuuu ugcgaucugc ucgagcagau u 31
<210> 1157
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1157
ggaucuuuug cgaucugcuc gagcagauuu g 31
<210> 1158
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1158
gaucuuuugc gaucugcucg agcagauuug g 31
<210> 1159
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1159
aucuuuugcg aucugcucga gcagauuugg c 31
<210> 1160
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1160
uuuuuccaac ugcuuucuga aaggggugag g 31
<210> 1161
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1161
uuuuccaacu gcuuucugaa aggggugagg a 31
<210> 1162
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1162
gcuuucugaa aggggugagg aucuaccuua a 31
<210> 1163
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1163
cugaaagggg ugaggaucua ccuuaauaug c 31
<210> 1164
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1164
uuuuuuccaa cugcuuucug aaagggguga g 31
<210> 1165
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1165
cuuucugaaa ggggugagga ucuaccuuaa u 31
<210> 1166
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1166
uuuuuuucca acugcuuucu gaaaggggug a 31
<210> 1167
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1167
gcugcagcuc caggagggua uucaccaccu c 31
<210> 1168
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1168
gcugugugac acaccgcaag ggcuugggau c 31
<210> 1169
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1169
agcugcagcu ccaggagggu auucaccacc u 31
<210> 1170
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1170
cugcagcucc aggaggguau ucaccaccuc u 31
<210> 1171
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1171
ugcagcucca ggaggguauu caccaccucu c 31
<210> 1172
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1172
gcagcuccag gaggguauuc accaccucuc a 31
<210> 1173
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1173
cagcuccagg aggguauuca ccaccucuca g 31
<210> 1174
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1174
gcuccaggag gguauucacc accucucagu g 31
<210> 1175
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1175
cuccaggagg guauucacca ccucucagug g 31
<210> 1176
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1176
uccaggaggg uauucaccac cucucagugg c 31
<210> 1177
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1177
ccaggagggu auucaccacc ucucaguggc a 31
<210> 1178
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1178
agcuguguga cacaccgcaa gggcuuggga u 31
<210> 1179
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1179
cugugugaca caccgcaagg gcuugggauc u 31
<210> 1180
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1180
caggagggua uucaccaccu cucaguggca a 31
<210> 1181
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1181
ugugugacac accgcaaggg cuugggaucu u 31
<210> 1182
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1182
gugugacaca ccgcaagggc uugggaucuu u 31
<210> 1183
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1183
agcuccagga ggguauucac caccucucag u 31
<210> 1184
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1184
ggaggguauu caccaccucu caguggcaau g 31
<210> 1185
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1185
gaggguauuc accaccucuc aguggcaaug c 31
<210> 1186
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1186
aggguauuca ccaccucuca guggcaaugc g 31
<210> 1187
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1187
ggguauucac caccucucag uggcaaugcg a 31
<210> 1188
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1188
aggaggguau ucaccaccuc ucaguggcaa u 31
<210> 1189
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1189
guggugcuga aguuuauucg gauuuauuuu u 31
<210> 1190
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1190
uggugcugaa guuuauucgg auuuauuuuu u 31
<210> 1191
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1191
gggcuuggga ucuuuugcga ucugcucgag c 31
<210> 1192
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1192
cguggugcug aaguuuauuc ggauuuauuu u 31
<210> 1193
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1193
auucggauuu auuuuuuucc aacugcuuuc u 31
<210> 1194
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1194
ccgcaagggc uugggaucuu uugcgaucug c 31
<210> 1195
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1195
cgcaagggcu ugggaucuuu ugcgaucugc u 31
<210> 1196
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1196
gcaagggcuu gggaucuuuu gcgaucugcu c 31
<210> 1197
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1197
caagggcuug ggaucuuuug cgaucugcuc g 31
<210> 1198
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1198
agggcuuggg aucuuuugcg aucugcucga g 31
<210> 1199
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1199
ccguggugcu gaaguuuauu cggauuuauu u 31
<210> 1200
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1200
uucggauuua uuuuuuucca acugcuuucu g 31
<210> 1201
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1201
ucggauuuau uuuuuuccaa cugcuuucug a 31
<210> 1202
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1202
cggauuuauu uuuuuccaac ugcuuucuga a 31
<210> 1203
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1203
ggauuuauuu uuuuccaacu gcuuucugaa a 31
<210> 1204
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1204
gauuuauuuu uuuccaacug cuuucugaaa g 31
<210> 1205
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1205
auuuauuuuu uuccaacugc uuucugaaag g 31
<210> 1206
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1206
caccgcaagg gcuugggauc uuuugcgauc u 31
<210> 1207
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1207
accgcaaggg cuugggaucu uuugcgaucu g 31
<210> 1208
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1208
aagggcuugg gaucuuuugc gaucugcucg a 31
<210> 1209
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1209
gggaucuuuu gcgaucugcu cgagcagauu u 31
<210> 1210
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1210
auuuuuuucc aacugcuuuc ugaaaggggu g 31
<210> 1211
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1211
uuauuuuuuu ccaacugcuu ucugaaaggg g 31
<210> 1212
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1212
uauuuuuuuc caacugcuuu cugaaagggg u 31
<210> 1213
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1213
uuuauuuuuu uccaacugcu uucugaaagg g 31
<210> 1214
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1214
gacacaccgc aagggcuugg gaucuuuugc g 31
<210> 1215
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1215
gugacacacc gcaagggcuu gggaucuuuu g 31
<210> 1216
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1216
ugacacaccg caagggcuug ggaucuuuug c 31
<210> 1217
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1217
cacaccgcaa gggcuuggga ucuuuugcga u 31
<210> 1218
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1218
acaccgcaag ggcuugggau cuuuugcgau c 31
<210> 1219
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1219
ugugacacac cgcaagggcu ugggaucuuu u 31
<210> 1220
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1220
acacaccgca agggcuuggg aucuuuugcg a 31
<210> 1221
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1221
ggugcugaag uuuauucgga uuuauuuuuu u 31
<210> 1222
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1222
gugcugaagu uuauucggau uuauuuuuuu c 31
<210> 1223
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1223
uauucggauu uauuuuuuuc caacugcuuu c 31
<210> 1224
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1224
uuuauucgga uuuauuuuuu uccaacugcu u 31
<210> 1225
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1225
uuauucggau uuauuuuuuu ccaacugcuu u 31
<210> 1226
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1226
ugcugaaguu uauucggauu uauuuuuuuc c 31
<210> 1227
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1227
gcugaaguuu auucggauuu auuuuuuucc a 31
<210> 1228
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1228
aguuuauucg gauuuauuuu uuuccaacug c 31
<210> 1229
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1229
guuuauucgg auuuauuuuu uuccaacugc u 31
<210> 1230
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1230
cugaaguuua uucggauuua uuuuuuucca a 31
<210> 1231
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1231
ugaaguuuau ucggauuuau uuuuuuccaa c 31
<210> 1232
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1232
gaaguuuauu cggauuuauu uuuuuccaac u 31
<210> 1233
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1233
aaguuuauuc ggauuuauuu uuuuccaacu g 31
<210> 1234
<211> 73
<212> RNA
<213> Homo sapiens (智人)
<400> 1234
ggccggcugg gguuccuggg gaugggauuu gcuuccuguc acaaaucaca uugccaggga 60
uuuccaaccg acc 73
<210> 1235
<211> 21
<212> RNA
<213> Homo sapiens (智人)
<400> 1235
aucacauugc cagggauuuc c 21
<210> 1236
<211> 21
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1236
ggaaatccct ggcaatgtga t 21
<210> 1237
<211> 21
<212> DNA
<213> Homo sapiens (智人)
<400> 1237
ggtaatccct ggcaatgtga t 21
<210> 1238
<211> 20
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1238
tgttgtttgg cttttcctgt 20
<210> 1239
<211> 20
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1239
ttagattgaa acaacccagt 20
<210> 1240
<211> 31
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1240
ggagaagaac ggaaaucccu ggcaauguga u 31
<210> 1241
<211> 31
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1241
ggagaagaac ggaaatccct ggcaatgtga t 31
<210> 1242
<211> 46
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1242
cguucuucuc ccaggaaaag ccaaacaaca cucggccagg gauuuc 46
<210> 1243
<211> 23
<212> DNA
<213> Homo sapiens (智人)
<400> 1243
acggtcaata agaccagata aca 23
<210> 1244
<211> 23
<212> RNA
<213> Homo sapiens (智人)
<400> 1244
acggucaaua acaccagaua aca 23
<210> 1245
<211> 17
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1245
atctggtgtt attgacc 17
<210> 1246
<211> 17
<212> DNA
<213> Homo sapiens (智人)
<400> 1246
atctggtgta attgacc 17
<210> 1247
<211> 13
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1247
atctggtgtt att 13
<210> 1248
<211> 17
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1248
gagatctggt gttattg 17
<210> 1249
<211> 17
<212> DNA
<213> Homo sapiens (智人)
<400> 1249
gagatctggt cttattg 17
<210> 1250
<211> 14
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1250
gagatctggt gtta 14
<210> 1251
<211> 13
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1251
ctggtgttat tga 13
<210> 1252
<211> 14
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1252
gatctggtgt tatt 14
<210> 1253
<211> 201
<212> RNA
<213> Homo sapiens (智人)
<400> 1253
gaggaagucc uggcugcaga caccugcuuc ugauuccaca aggggcuuuu uccucaaccc 60
uguggccgcc uuugaaguga cucauuuuuu uaauguauuu auguauuuau uugauuguuu 120
uauauaagau gguuucuuac cuuugagcac aaaauuucca cggugaaaua aagucaacau 180
uauaagcuuu aaaaaaaaaa a 201
<210> 1254
<211> 25
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1254
cgagaucugg uguuauugac cguuu 25
<210> 1255
<211> 46
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1255
ccugcuucug auacggucaa uaacaccaga ucucgggcug cagaca 46
<210> 1256
<211> 20
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1256
aggtgtctgc agccaggact 20
<210> 1257
<211> 20
<212> DNA
<213> Homo sapiens (智人)
<400> 1257
aggtgtctgc aggcaggact 20
<210> 1258
<211> 20
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1258
agcaggtgtc tgcagccagg 20
<210> 1259
<211> 20
<212> DNA
<213> Homo sapiens (智人)
<400> 1259
agcaggtctc tgcagccagg 20
<210> 1260
<211> 46
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1260
gauucgacaa gacggucaau aacaccagau cucgacaccu gcuucu 46
<210> 1261
<211> 16
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1261
agaagcaggt gtctgc 16
<210> 1262
<211> 16
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1262
gaatcagaag caggtg 16
<210> 1263
<211> 16
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1263
aagcaggtgt ctgcag 16
<210> 1264
<211> 15
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1264
atcagaagca ggtgt 15
<210> 1265
<211> 19
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1265
gaagcaggtg tctgcagcc 19
<210> 1266
<211> 19
<212> DNA
<213> Homo sapiens (智人)
<400> 1266
gaagcaggtg cctgcagcc 19
<210> 1267
<211> 15
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1267
tgtggaatca gaagc 15
<210> 1268
<211> 46
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1268
ggccgccuuu gacggucaau aacaccagau cucgccucaa gccugu 46
<210> 1269
<211> 16
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1269
ggccacaggg ttgagg 16
<210> 1270
<211> 15
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1270
agggttgagg aaaaa 15
<210> 1271
<211> 130
<212> RNA
<213> Homo sapiens (智人)
<400> 1271
uuuuuuuuuu uuuuucucgg cuucaaggaa aauugcuuua uucugcuucc ucccaaggag 60
cuguuacaca ggcuccagca uggggcuuug cuggcaccuc cagggcugag cagaucaaga 120
uguggcaaag 130
<210> 1272
<211> 46
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1272
gcagaucaag auacggucaa uaacaccaga ucucguccag ggcuga 46
<210> 1273
<211> 16
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1273
cttgatctgc tcagcc 16
<210> 1274
<211> 16
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1274
atcttgatct gctcag 16
<210> 1275
<211> 31
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1275
caacaagatg acacaaatgc agcagagacc c 31
<210> 1276
<211> 31
<212> DNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1276
atgacacaaa tgcagcagag accccagggg a 31
<210> 1277
<211> 46
<212> RNA
<213> Artificial Sequence (人工序列)
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide (人工序列的描述:合成寡核苷酸)
<400> 1277
gucaucuugu ugcaggaaaa gccaaacaac acucggcugc auuugu 46
<210> 1278
<211> 116
<212> DNA
<213> Homo sapiens (智人)
<400> 1278
gctttgccac atcttgatct gctcagccct ggaggtgcca gcaaagcccc atgctggagc 60
ctgtgtaaca gctccttggg aggaagcaga ataaagcaat tttccttgaa gccgag 116
<210> 1279
<211> 297
<212> DNA
<213> Homo sapiens (智人)
<400> 1279
agataacagc cagggaggac aagcagggct gggcctaggg acagactgca agaggctcct 60
gtcccctggg gtctctgctg catttgtgtc atcttgttgc catggagttg tgatcatccc 120
atctaagctg cagcttcctg tcaacacttc tcacatctta tgctaactgt agataaagtg 180
gtttgatggt gacttcctcg cctctcccac cccatgcatt aaattttaag gtagaacctc 240
acctgttact gaaagtggtt tgaaagtgaa taaacttcag caccatggac agaagac 297
<210> 1280
<211> 190
<212> DNA
<213> Homo sapiens (智人)
<400> 1280
gaggaagtcc tggctgcaga cacctgcttc tgattccaca aggggctttt tcctcaaccc 60
tgtggccgcc tttgaagtga ctcatttttt taatgtattt atgtatttat ttgattgttt 120
tatataagat ggtttcttac ctttgagcac aaaatttcca cggtgaaata aagtcaacat 180
tataagcttt 190
<210> 1281
<211> 105
<212> DNA
<213> Rattus norvegicus (褐家鼠)
<400> 1281
atcttgtgct acccaaccct aaggatgcct gtgaagccct gagacctgga gcctttgaaa 60
cagcacctta ggcagaaaca caataaagca attttccttc aagcc 105
<210> 1282
<211> 279
<212> DNA
<213> Rattus norvegicus (褐家鼠)
<400> 1282
cagccaaatc tgctcgagca gatcgcaaaa gatcccaagc ccttgcggtg tgtcacacag 60
cttggtcgca ttgccactga gaggtggtga ataccctcct ggagctgcag cttcctgtct 120
tcatctatca cgatcgatgt taagtgtaga tgagtggttt agtgaggcct tacctctccc 180
actctgcata ttaaggtaga tcctcacccc tttcagaaag cagttggaaa aaaataaatc 240
cgaataaact tcagcaccac ggacagacgc tgaggcctg 279
<210> 1283
<211> 205
<212> DNA
<213> Rattus norvegicus (褐家鼠)
<400> 1283
gaagacctcc tggctgcaga ctccggcttc tgactctgcc tgcggctctt ctttccccag 60
ctctgggacc acctctcaag tgatcctgtt tatttatttg tttatttatt tatttttatg 120
ttgctgattt tctacaagac tgtttcttat cttccagcac aaacttgcca cagtgtaata 180
aacatagcct atttcttgct tttgg 205
<210> 1284
<211> 1935
<212> PRT
<213> Homo sapiens (智人)
<400> 1284
Met Gly Asp Ser Glu Met Ala Val Phe Gly Ala Ala Ala Pro Tyr Leu
1 5 10 15
Arg Lys Ser Glu Lys Glu Arg Leu Glu Ala Gln Thr Arg Pro Phe Asp
20 25 30
Leu Lys Lys Asp Val Phe Val Pro Asp Asp Lys Gln Glu Phe Val Lys
35 40 45
Ala Lys Ile Val Ser Arg Glu Gly Gly Lys Val Thr Ala Glu Thr Glu
50 55 60
Tyr Gly Lys Thr Val Thr Val Lys Glu Asp Gln Val Met Gln Gln Asn
65 70 75 80
Pro Pro Lys Phe Asp Lys Ile Glu Asp Met Ala Met Leu Thr Phe Leu
85 90 95
His Glu Pro Ala Val Leu Tyr Asn Leu Lys Asp Arg Tyr Gly Ser Trp
100 105 110
Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro Tyr
115 120 125
Lys Trp Leu Pro Val Tyr Thr Pro Glu Val Val Ala Ala Tyr Arg Gly
130 135 140
Lys Lys Arg Ser Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp Asn
145 150 155 160
Ala Tyr Gln Tyr Met Leu Thr Asp Arg Glu Asn Gln Ser Ile Leu Ile
165 170 175
Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys Arg Val Ile
180 185 190
Gln Tyr Phe Ala Val Ile Ala Ala Ile Gly Asp Arg Ser Lys Lys Asp
195 200 205
Gln Ser Pro Gly Lys Gly Thr Leu Glu Asp Gln Ile Ile Gln Ala Asn
210 215 220
Pro Ala Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg Asn Asp Asn
225 230 235 240
Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly Ala Thr Gly
245 250 255
Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu Lys Ser Arg
260 265 270
Val Ile Phe Gln Leu Lys Ala Glu Arg Asp Tyr His Ile Phe Tyr Gln
275 280 285
Ile Leu Ser Asn Lys Lys Pro Glu Leu Leu Asp Met Leu Leu Ile Thr
290 295 300
Asn Asn Pro Tyr Asp Tyr Ala Phe Ile Ser Gln Gly Glu Thr Thr Val
305 310 315 320
Ala Ser Ile Asp Asp Ala Glu Glu Leu Met Ala Thr Asp Asn Ala Phe
325 330 335
Asp Val Leu Gly Phe Thr Ser Glu Glu Lys Asn Ser Met Tyr Lys Leu
340 345 350
Thr Gly Ala Ile Met His Phe Gly Asn Met Lys Phe Lys Leu Lys Gln
355 360 365
Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Glu Ala Asp Lys Ser
370 375 380
Ala Tyr Leu Met Gly Leu Asn Ser Ala Asp Leu Leu Lys Gly Leu Cys
385 390 395 400
His Pro Arg Val Lys Val Gly Asn Glu Tyr Val Thr Lys Gly Gln Asn
405 410 415
Val Gln Gln Val Ile Tyr Ala Thr Gly Ala Leu Ala Lys Ala Val Tyr
420 425 430
Glu Arg Met Phe Asn Trp Met Val Thr Arg Ile Asn Ala Thr Leu Glu
435 440 445
Thr Lys Gln Pro Arg Gln Tyr Phe Ile Gly Val Leu Asp Ile Ala Gly
450 455 460
Phe Glu Ile Phe Asp Phe Asn Ser Phe Glu Gln Leu Cys Ile Asn Phe
465 470 475 480
Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met Phe Val Leu
485 490 495
Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Thr Phe Ile Asp
500 505 510
Phe Gly Met Asp Leu Gln Ala Cys Ile Asp Leu Ile Glu Lys Pro Met
515 520 525
Gly Ile Met Ser Ile Leu Glu Glu Glu Cys Met Phe Pro Lys Ala Thr
530 535 540
Asp Met Thr Phe Lys Ala Lys Leu Phe Asp Asn His Leu Gly Lys Ser
545 550 555 560
Ala Asn Phe Gln Lys Pro Arg Asn Ile Lys Gly Lys Pro Glu Ala His
565 570 575
Phe Ser Leu Ile His Tyr Ala Gly Ile Val Asp Tyr Asn Ile Ile Gly
580 585 590
Trp Leu Gln Lys Asn Lys Asp Pro Leu Asn Glu Thr Val Val Gly Leu
595 600 605
Tyr Gln Lys Ser Ser Leu Lys Leu Leu Ser Thr Leu Phe Ala Asn Tyr
610 615 620
Ala Gly Ala Asp Ala Pro Ile Glu Lys Gly Lys Gly Lys Ala Lys Lys
625 630 635 640
Gly Ser Ser Phe Gln Thr Val Ser Ala Leu His Arg Glu Asn Leu Asn
645 650 655
Lys Leu Met Thr Asn Leu Arg Ser Thr His Pro His Phe Val Arg Cys
660 665 670
Ile Ile Pro Asn Glu Thr Lys Ser Pro Gly Val Met Asp Asn Pro Leu
675 680 685
Val Met His Gln Leu Arg Cys Asn Gly Val Leu Glu Gly Ile Arg Ile
690 695 700
Cys Arg Lys Gly Phe Pro Asn Arg Ile Leu Tyr Gly Asp Phe Arg Gln
705 710 715 720
Arg Tyr Arg Ile Leu Asn Pro Ala Ala Ile Pro Glu Gly Gln Phe Ile
725 730 735
Asp Ser Arg Lys Gly Ala Glu Lys Leu Leu Ser Ser Leu Asp Ile Asp
740 745 750
His Asn Gln Tyr Lys Phe Gly His Thr Lys Val Phe Phe Lys Ala Gly
755 760 765
Leu Leu Gly Leu Leu Glu Glu Met Arg Asp Glu Arg Leu Ser Arg Ile
770 775 780
Ile Thr Arg Ile Gln Ala Gln Ser Arg Gly Val Leu Ala Arg Met Glu
785 790 795 800
Tyr Lys Lys Leu Leu Glu Arg Arg Asp Ser Leu Leu Val Ile Gln Trp
805 810 815
Asn Ile Arg Ala Phe Met Gly Val Lys Asn Trp Pro Trp Met Lys Leu
820 825 830
Tyr Phe Lys Ile Lys Pro Leu Leu Lys Ser Ala Glu Arg Glu Lys Glu
835 840 845
Met Ala Ser Met Lys Glu Glu Phe Thr Arg Leu Lys Glu Ala Leu Glu
850 855 860
Lys Ser Glu Ala Arg Arg Lys Glu Leu Glu Glu Lys Met Val Ser Leu
865 870 875 880
Leu Gln Glu Lys Asn Asp Leu Gln Leu Gln Val Gln Ala Glu Gln Asp
885 890 895
Asn Leu Ala Asp Ala Glu Glu Arg Cys Asp Gln Leu Ile Lys Asn Lys
900 905 910
Ile Gln Leu Glu Ala Lys Val Lys Glu Met Asn Glu Arg Leu Glu Asp
915 920 925
Glu Glu Glu Met Asn Ala Glu Leu Thr Ala Lys Lys Arg Lys Leu Glu
930 935 940
Asp Glu Cys Ser Glu Leu Lys Arg Asp Ile Asp Asp Leu Glu Leu Thr
945 950 955 960
Leu Ala Lys Val Glu Lys Glu Lys His Ala Thr Glu Asn Lys Val Lys
965 970 975
Asn Leu Thr Glu Glu Met Ala Gly Leu Asp Glu Ile Ile Ala Lys Leu
980 985 990
Thr Lys Glu Lys Lys Ala Leu Gln Glu Ala His Gln Gln Ala Leu Asp
995 1000 1005
Asp Leu Gln Ala Glu Glu Asp Lys Val Asn Thr Leu Thr Lys Ala
1010 1015 1020
Lys Val Lys Leu Glu Gln Gln Val Asp Asp Leu Glu Gly Ser Leu
1025 1030 1035
Glu Gln Glu Lys Lys Val Arg Met Asp Leu Glu Arg Ala Lys Arg
1040 1045 1050
Lys Leu Glu Gly Asp Leu Lys Leu Thr Gln Glu Ser Ile Met Asp
1055 1060 1065
Leu Glu Asn Asp Lys Gln Gln Leu Asp Glu Arg Leu Lys Lys Lys
1070 1075 1080
Asp Phe Glu Leu Asn Ala Leu Asn Ala Arg Ile Glu Asp Glu Gln
1085 1090 1095
Ala Leu Gly Ser Gln Leu Gln Lys Lys Leu Lys Glu Leu Gln Ala
1100 1105 1110
Arg Ile Glu Glu Leu Glu Glu Glu Leu Glu Ala Glu Arg Thr Ala
1115 1120 1125
Arg Ala Lys Val Glu Lys Leu Arg Ser Asp Leu Ser Arg Glu Leu
1130 1135 1140
Glu Glu Ile Ser Glu Arg Leu Glu Glu Ala Gly Gly Ala Thr Ser
1145 1150 1155
Val Gln Ile Glu Met Asn Lys Lys Arg Glu Ala Glu Phe Gln Lys
1160 1165 1170
Met Arg Arg Asp Leu Glu Glu Ala Thr Leu Gln His Glu Ala Thr
1175 1180 1185
Ala Ala Ala Leu Arg Lys Lys His Ala Asp Ser Val Ala Glu Leu
1190 1195 1200
Gly Glu Gln Ile Asp Asn Leu Gln Arg Val Lys Gln Lys Leu Glu
1205 1210 1215
Lys Glu Lys Ser Glu Phe Lys Leu Glu Leu Asp Asp Val Thr Ser
1220 1225 1230
Asn Met Glu Gln Ile Ile Lys Ala Lys Ala Asn Leu Glu Lys Met
1235 1240 1245
Cys Arg Thr Leu Glu Asp Gln Met Asn Glu His Arg Ser Lys Ala
1250 1255 1260
Glu Glu Thr Gln Arg Ser Val Asn Asp Leu Thr Ser Gln Arg Ala
1265 1270 1275
Lys Leu Gln Thr Glu Asn Gly Glu Leu Ser Arg Gln Leu Asp Glu
1280 1285 1290
Lys Glu Ala Leu Ile Ser Gln Leu Thr Arg Gly Lys Leu Thr Tyr
1295 1300 1305
Thr Gln Gln Leu Glu Asp Leu Lys Arg Gln Leu Glu Glu Glu Val
1310 1315 1320
Lys Ala Lys Asn Ala Leu Ala His Ala Leu Gln Ser Ala Arg His
1325 1330 1335
Asp Cys Asp Leu Leu Arg Glu Gln Tyr Glu Glu Glu Thr Glu Ala
1340 1345 1350
Lys Ala Glu Leu Gln Arg Val Leu Ser Lys Ala Asn Ser Glu Val
1355 1360 1365
Ala Gln Trp Arg Thr Lys Tyr Glu Thr Asp Ala Ile Gln Arg Thr
1370 1375 1380
Glu Glu Leu Glu Glu Ala Lys Lys Lys Leu Ala Gln Arg Leu Gln
1385 1390 1395
Glu Ala Glu Glu Ala Val Glu Ala Val Asn Ala Lys Cys Ser Ser
1400 1405 1410
Leu Glu Lys Thr Lys His Arg Leu Gln Asn Glu Ile Glu Asp Leu
1415 1420 1425
Met Val Asp Val Glu Arg Ser Asn Ala Ala Ala Ala Ala Leu Asp
1430 1435 1440
Lys Lys Gln Arg Asn Phe Asp Lys Ile Leu Ala Glu Trp Lys Gln
1445 1450 1455
Lys Tyr Glu Glu Ser Gln Ser Glu Leu Glu Ser Ser Gln Lys Glu
1460 1465 1470
Ala Arg Ser Leu Ser Thr Glu Leu Phe Lys Leu Lys Asn Ala Tyr
1475 1480 1485
Glu Glu Ser Leu Glu His Leu Glu Thr Phe Lys Arg Glu Asn Lys
1490 1495 1500
Asn Leu Gln Glu Glu Ile Ser Asp Leu Thr Glu Gln Leu Gly Ser
1505 1510 1515
Ser Gly Lys Thr Ile His Glu Leu Glu Lys Val Arg Lys Gln Leu
1520 1525 1530
Glu Ala Glu Lys Met Glu Leu Gln Ser Ala Leu Glu Glu Ala Glu
1535 1540 1545
Ala Ser Leu Glu His Glu Glu Gly Lys Ile Leu Arg Ala Gln Leu
1550 1555 1560
Glu Phe Asn Gln Ile Lys Ala Glu Ile Glu Arg Lys Leu Ala Glu
1565 1570 1575
Lys Asp Glu Glu Met Glu Gln Ala Lys Arg Asn His Leu Arg Val
1580 1585 1590
Val Asp Ser Leu Gln Thr Ser Leu Asp Ala Glu Thr Arg Ser Arg
1595 1600 1605
Asn Glu Ala Leu Arg Val Lys Lys Lys Met Glu Gly Asp Leu Asn
1610 1615 1620
Glu Met Glu Ile Gln Leu Ser His Ala Asn Arg Met Ala Ala Glu
1625 1630 1635
Ala Gln Lys Gln Val Lys Ser Leu Gln Ser Leu Leu Lys Asp Thr
1640 1645 1650
Gln Ile Gln Leu Asp Asp Ala Val Arg Ala Asn Asp Asp Leu Lys
1655 1660 1665
Glu Asn Ile Ala Ile Val Glu Arg Arg Asn Asn Leu Leu Gln Ala
1670 1675 1680
Glu Leu Glu Glu Leu Arg Ala Val Val Glu Gln Thr Glu Arg Ser
1685 1690 1695
Arg Lys Leu Ala Glu Gln Glu Leu Ile Glu Thr Ser Glu Arg Val
1700 1705 1710
Gln Leu Leu His Ser Gln Asn Thr Ser Leu Ile Asn Gln Lys Lys
1715 1720 1725
Lys Met Asp Ala Asp Leu Ser Gln Leu Gln Thr Glu Val Glu Glu
1730 1735 1740
Ala Val Gln Glu Cys Arg Asn Ala Glu Glu Lys Ala Lys Lys Ala
1745 1750 1755
Ile Thr Asp Ala Ala Met Met Ala Glu Glu Leu Lys Lys Glu Gln
1760 1765 1770
Asp Thr Ser Ala His Leu Glu Arg Met Lys Lys Asn Met Glu Gln
1775 1780 1785
Thr Ile Lys Asp Leu Gln His Arg Leu Asp Glu Ala Glu Gln Ile
1790 1795 1800
Ala Leu Lys Gly Gly Lys Lys Gln Leu Gln Lys Leu Glu Ala Arg
1805 1810 1815
Val Arg Glu Leu Glu Asn Glu Leu Glu Ala Glu Gln Lys Arg Asn
1820 1825 1830
Ala Glu Ser Val Lys Gly Met Arg Lys Ser Glu Arg Arg Ile Lys
1835 1840 1845
Glu Leu Thr Tyr Gln Thr Glu Glu Asp Arg Lys Asn Leu Leu Arg
1850 1855 1860
Leu Gln Asp Leu Val Asp Lys Leu Gln Leu Lys Val Lys Ala Tyr
1865 1870 1875
Lys Arg Gln Ala Glu Glu Ala Glu Glu Gln Ala Asn Thr Asn Leu
1880 1885 1890
Ser Lys Phe Arg Lys Val Gln His Glu Leu Asp Glu Ala Glu Glu
1895 1900 1905
Arg Ala Asp Ile Ala Glu Ser Gln Val Asn Lys Leu Arg Ala Lys
1910 1915 1920
Ser Arg Asp Ile Gly Thr Lys Gly Leu Asn Glu Glu
1925 1930 1935
<210> 1285
<211> 6069
<212> DNA
<213> Homo sapiens (智人)
<400> 1285
cagcccctga gaccaggtct ggctccacag ctctgtcctg ctctgtgtct ttccctgctg 60
ctctcaggtc ccctgcaggc cttggcccct ttcctcatct gtagacacac ttgagtagcc 120
caggcacagc catgggagat tcggagatgg cagtctttgg ggctgccgcc ccctacctgc 180
gcaagtcaga gaaggagcgg ctagaagcgc agaccaggcc ttttgacctc aagaaggatg 240
tcttcgtgcc tgatgacaaa caggagtttg tcaaggccaa gatcgtgtct cgagagggtg 300
gcaaagtcac tgccgagacc gagtatggca agacagtgac cgtgaaggag gaccaggtga 360
tgcagcagaa cccacccaag ttcgacaaaa tcgaggacat ggccatgctg accttcctgc 420
atgagcccgc ggtgctctac aacctcaagg atcgctacgg ctcctggatg atctacacct 480
actcgggcct cttctgtgtc accgtcaacc cttacaagtg gctgccggtg tacactcctg 540
aggtggtggc tgcctaccgg ggcaagaaga ggagcgaggc cccgccccac atcttctcca 600
tctccgacaa cgcctatcag tacatgctga cagacagaga aaaccagtcc atcctgatca 660
ccggagaatc cggagcaggg aagacagtca acaccaagag ggtcatccag tactttgctg 720
ttattgcagc cattggggac cgcagcaaga aggaccagag cccgggcaag ggcaccctgg 780
aggaccagat catccaggcc aaccctgctc tggaggcctt tggcaatgcc aagaccgtcc 840
ggaacgacaa ctcctcccgc ttcgggaaat tcattcgaat tcattttggg gcaacaggaa 900
agttggcatc tgcagacata gagacctatc ttctggaaaa atccagagtt attttccagc 960
tgaaagcaga gagagattat cacattttct accaaatcct gtctaacaaa aagcctgagc 1020
tgctggacat gctgctgatc accaacaacc cctacgatta tgcattcatc tcccaaggag 1080
agaccaccgt ggcctccatt gatgacgctg aggagctcat ggccactgat aacgcttttg 1140
atgtgctggg cttcacttca gaggagaaaa actccatgta taagctgaca ggcgccatca 1200
tgcactttgg aaacatgaag ttcaagctga agcagcggga ggagcaggcg gagccagacg 1260
gcactgaaga ggctgacaag tctgcctacc tcatggggct gaactcagcc gacctgctca 1320
aggggctgtg ccaccctcgg gtgaaagtgg gcaatgagta cgtcaccaag gggcagaatg 1380
tccagcaggt gatatatgcc actggggcac tggccaaggc agtgtatgag aggatgttca 1440
actggatggt gacgcgcatc aatgccaccc tggagaccaa gcagccacgc cagtacttca 1500
taggagtcct ggacatcgct ggcttcgaga tcttcgattt caacagcttt gagcagctct 1560
gcatcaactt caccaacgag aagctgcagc agttcttcaa ccaccacatg tttgtgctgg 1620
agcaggagga gtacaagaag gagggcatcg agtggacatt cattgacttt ggcatggacc 1680
tgcaggcctg cattgacctc atcgagaagc ccatgggcat catgtccatc ctggaagagg 1740
agtgcatgtt ccccaaggcc accgacatga ccttcaaggc caagctgttt gacaaccacc 1800
tgggcaaatc cgccaacttc cagaagccac gcaatatcaa ggggaagcct gaagcccact 1860
tctccctgat ccactatgcc ggcatcgtgg actacaacat cattggctgg ctgcagaaga 1920
acaaggatcc tctcaatgag actgtcgtgg gcttgtatca gaagtcttcc ctcaagctgc 1980
tcagcaccct gtttgccaac tatgctgggg ctgatgcgcc tattgagaag ggcaaaggca 2040
aggccaagaa aggctcgtcc tttcagactg tgtcagctct gcacagggaa aatctgaaca 2100
agctgatgac caacttgcgc tccacccatc cccactttgt acgttgtatc atccctaatg 2160
agacaaagtc tccaggggtg atggacaacc ccctggtcat gcaccagctg cgctgcaatg 2220
gtgtgctgga gggcatccgc atctgcagga aaggcttccc caaccgcatc ctctacgggg 2280
acttccggca gaggtatcgc atcctgaacc cagcggccat ccctgaggga cagttcattg 2340
atagcaggaa gggggcagag aagctgctca gctccctgga cattgatcac aaccagtaca 2400
agtttggcca caccaaggtg ttcttcaagg ccgggctgct ggggctgctg gaggaaatga 2460
gggacgagag gctgagccgc atcatcacgc gtatccaggc ccagtcccga ggtgtgctcg 2520
ccagaatgga gtacaaaaag ctgctggaac gtagagactc cctgctggta atccagtgga 2580
acattcgggc cttcatgggg gtcaagaatt ggccctggat gaagctctac ttcaagatca 2640
agccgctgct gaagagtgca gaaagagaga aggagatggc ctccatgaag gaggagttca 2700
cacgcctcaa agaggcgcta gagaagtccg aggctcgccg caaggagctg gaggagaaga 2760
tggtgtccct gctgcaggag aagaatgacc tgcagctcca agtgcaggcg gaacaagaca 2820
acctggcaga tgctgaggag cgctgtgatc agctgatcaa aaacaagatt cagctggagg 2880
ccaaggtgaa ggagatgaac gagaggctgg aggatgagga ggagatgaat gctgagctca 2940
ctgccaagaa gcgcaagctg gaagatgagt gctcagagct caaaagggac atcgatgatc 3000
tggagctgac actggccaaa gtggagaagg agaaacacgc aacagagaac aaggtgaaaa 3060
acctgacaga ggagatggct gggctggatg agatcattgc caagctgacc aaggagaaga 3120
aagctctgca agaggcccac caacaggctc tggatgacct tcaggccgag gaggacaagg 3180
tcaacaccct gactaaggcc aaagtcaagc tggagcagca agtggatgat ctggaaggat 3240
ccctggagca agagaagaag gtgcgcatgg acctggagcg agcgaagcgg aagctggagg 3300
gcgacctgaa gctgacccag gagagcatca tggacctgga gaatgacaag cagcagctgg 3360
atgagcggct gaaaaaaaaa gactttgagc tgaatgctct caacgcaagg attgaggatg 3420
aacaggccct cggcagccag ctgcagaaga agctcaagga gcttcaggca cgcatcgagg 3480
agctggagga ggagctggag gccgagcgca ccgccagggc taaggtggag aagctgcgct 3540
cagacctgtc tcgggagctg gaggagatca gcgagcggct ggaagaggcc ggcggggcca 3600
cgtccgtgca gatcgagatg aacaagaagc gcgaggccga gttccagaag atgcggcggg 3660
acctggagga ggccacgctg cagcacgagg ccactgccgc ggccctgcgc aagaagcacg 3720
ccgacagcgt ggccgagctg ggcgagcaga tcgacaacct gcagcgggtg aagcagaagc 3780
tggagaagga gaagagcgag ttcaagctgg agctggatga cgtcacctcc aacatggagc 3840
agatcatcaa ggccaaggct aacctggaga agatgtgccg gaccttggaa gaccagatga 3900
atgagcaccg gagcaaggcg gaggagaccc agcgttctgt caacgacctc accagccagc 3960
gggccaagtt gcaaaccgag aatggtgagc tgtcccggca gctggatgag aaggaggcac 4020
tgatctccca gctgacccga ggcaagctca cctacaccca gcagctggag gacctcaaga 4080
ggcagctgga ggaggaggtt aaggcgaaga acgccctggc ccacgcactg cagtcggccc 4140
ggcatgactg cgacctgctg cgggagcagt acgaggagga gacggaggcc aaggccgagc 4200
tgcagcgcgt cctttccaag gccaactcgg aggtggccca gtggaggacc aagtatgaga 4260
cggacgccat tcagcggact gaggagctcg aggaggccaa gaagaagctg gcccagcggc 4320
tgcaggaagc tgaggaggcc gtggaggctg ttaatgccaa gtgctcctcg ctggagaaga 4380
ccaagcaccg gctacagaat gagatcgagg acttgatggt ggacgtagag cgctccaatg 4440
ctgctgctgc agccctggac aagaagcaga ggaacttcga caagatcctg gccgagtgga 4500
agcagaagta tgaggagtcg cagtcggagc tggagtcctc gcagaaggag gctcgctccc 4560
tcagcacaga gctcttcaaa ctcaagaacg cctatgagga gtccctggaa catctggaga 4620
ccttcaagcg ggagaacaaa aacctgcagg aggagatctc cgacttgact gagcagttgg 4680
gttccagcgg aaagactatc catgagctgg agaaggtccg aaagcagctg gaggccgaga 4740
agatggagct gcagtcagcc ctggaggagg ccgaggcctc cctggagcac gaggagggca 4800
agatcctccg ggcccagctg gagttcaacc agatcaaggc agagatcgag cggaagctgg 4860
cagagaagga cgaggagatg gaacaggcca agcgcaacca cctgcgggtg gtggactcgc 4920
tgcagacctc cctggacgca gagacacgca gccgcaacga ggccctgagg gtgaagaaga 4980
agatggaagg agacctcaat gagatggaga tccagctcag ccacgccaac cgcatggccg 5040
ccgaggccca gaagcaagtc aagagcctcc agagcttgtt gaaggacacc cagattcagc 5100
tggacgatgc agtccgtgcc aacgacgacc tgaaggagaa catcgccatc gtggagcggc 5160
gcaacaacct gctgcaggct gagctggagg agttgcgtgc cgtggtggag cagacagagc 5220
ggtcccggaa gctggcggag caggagctga ttgagactag tgagcgggtg cagctgctgc 5280
attcccagaa caccagcctc atcaaccaga agaagaagat ggatgctgac ctgtcccagc 5340
tccagactga agtggaggag gcagtgcagg agtgcaggaa tgctgaggag aaggccaaga 5400
aggccatcac ggatgccgcc atgatggcag aggagctgaa gaaggagcag gacaccagcg 5460
cccacctgga gcgcatgaag aagaacatgg aacagaccat taaggacctg cagcaccggc 5520
tggacgaagc cgagcagatc gccctcaagg gcggcaagaa gcagctgcag aagctggaag 5580
cgcgggtgcg ggagctggag aatgagctgg aggccgagca gaagcgcaac gcagagtcgg 5640
tgaagggcat gaggaagagc gagcggcgca tcaaggagct cacctaccag acggaggagg 5700
acaggaaaaa cctgctgcgg ctgcaggacc tggtagacaa gctgcagcta aaggtcaagg 5760
cctacaagcg ccaggccgag gaggcggagg agcaagccaa caccaacctg tccaagttcc 5820
gcaaggtgca gcacgagctg gatgaggcag aggagcgggc ggacatcgcc gagtcccagg 5880
tcaacaagct gcgggccaag agccgtgaca ttggcacgaa gggcttgaat gaggagtagc 5940
tttgccacat cttgatctgc tcagccctgg aggtgccagc aaagccccat gctggagcct 6000
gtgtaacagc tccttgggag gaagcagaat aaagcaattt tccttgaagc cgagaaaaaa 6060
aaaaaaaaa 6069
<210> 1286
<211> 151
<212> PRT
<213> Homo sapiens (智人)
<400> 1286
Met Ser Ser Phe Ser Thr Thr Thr Val Ser Phe Leu Leu Leu Leu Ala
1 5 10 15
Phe Gln Leu Leu Gly Gln Thr Arg Ala Asn Pro Met Tyr Asn Ala Val
20 25 30
Ser Asn Ala Asp Leu Met Asp Phe Lys Asn Leu Leu Asp His Leu Glu
35 40 45
Glu Lys Met Pro Leu Glu Asp Glu Val Val Pro Pro Gln Val Leu Ser
50 55 60
Glu Pro Asn Glu Glu Ala Gly Ala Ala Leu Ser Pro Leu Pro Glu Val
65 70 75 80
Pro Pro Trp Thr Gly Glu Val Ser Pro Ala Gln Arg Asp Gly Gly Ala
85 90 95
Leu Gly Arg Gly Pro Trp Asp Ser Ser Asp Arg Ser Ala Leu Leu Lys
100 105 110
Ser Lys Leu Arg Ala Leu Leu Thr Ala Pro Arg Ser Leu Arg Arg Ser
115 120 125
Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly Ala Gln Ser Gly Leu
130 135 140
Gly Cys Asn Ser Phe Arg Tyr
145 150
<210> 1287
<211> 858
<212> DNA
<213> Homo sapiens (智人)
<400> 1287
gagacaggga cagacgtagg ccaagagagg ggaaccagag aggaaccaga ggggagagac 60
agagcagcaa gcagtggatt gctccttgac gacgccagca tgagctcctt ctccaccacc 120
accgtgagct tcctcctttt actggcattc cagctcctag gtcagaccag agctaatccc 180
atgtacaatg ccgtgtccaa cgcagacctg atggatttca agaatttgct ggaccatttg 240
gaagaaaaga tgcctttaga agatgaggtc gtgcccccac aagtgctcag tgagccgaat 300
gaagaagcgg gggctgctct cagccccctc cctgaggtgc ctccctggac cggggaagtc 360
agcccagccc agagagatgg aggtgccctc gggcggggcc cctgggactc ctctgatcga 420
tctgccctcc taaaaagcaa gctgagggcg ctgctcactg cccctcggag cctgcggaga 480
tccagctgct tcgggggcag gatggacagg attggagccc agagcggact gggctgtaac 540
agcttccggt actgaagata acagccaggg aggacaagca gggctgggcc tagggacaga 600
ctgcaagagg ctcctgtccc ctggggtctc tgctgcattt gtgtcatctt gttgccatgg 660
agttgtgatc atcccatcta agctgcagct tcctgtcaac acttctcaca tcttatgcta 720
actgtagata aagtggtttg atggtgactt cctcgcctct cccaccccat gcattaaatt 780
ttaaggtaga acctcacctg ttactgaaag tggtttgaaa gtgaataaac ttcagcacca 840
tggacagaag acaaaaaa 858
<210> 1288
<211> 134
<212> PRT
<213> Homo sapiens (智人)
<400> 1288
Met Asp Pro Gln Thr Ala Pro Ser Arg Ala Leu Leu Leu Leu Leu Phe
1 5 10 15
Leu His Leu Ala Phe Leu Gly Gly Arg Ser His Pro Leu Gly Ser Pro
20 25 30
Gly Ser Ala Ser Asp Leu Glu Thr Ser Gly Leu Gln Glu Gln Arg Asn
35 40 45
His Leu Gln Gly Lys Leu Ser Glu Leu Gln Val Glu Gln Thr Ser Leu
50 55 60
Glu Pro Leu Gln Glu Ser Pro Arg Pro Thr Gly Val Trp Lys Ser Arg
65 70 75 80
Glu Val Ala Thr Glu Gly Ile Arg Gly His Arg Lys Met Val Leu Tyr
85 90 95
Thr Leu Arg Ala Pro Arg Ser Pro Lys Met Val Gln Gly Ser Gly Cys
100 105 110
Phe Gly Arg Lys Met Asp Arg Ile Ser Ser Ser Ser Gly Leu Gly Cys
115 120 125
Lys Val Leu Arg Arg His
130
<210> 1289
<211> 708
<212> DNA
<213> Homo sapiens (智人)
<400> 1289
ccccgcaggc tgagggcagg tgggaagcaa acccggacgc atcgcagcag cagcagcagc 60
agcagaagca gcagcagcag cctccgcagt ccctccagag acatggatcc ccagacagca 120
ccttcccggg cgctcctgct cctgctcttc ttgcatctgg ctttcctggg aggtcgttcc 180
cacccgctgg gcagccccgg ttcagcctcg gacttggaaa cgtccgggtt acaggagcag 240
cgcaaccatt tgcagggcaa actgtcggag ctgcaggtgg agcagacatc cctggagccc 300
ctccaggaga gcccccgtcc cacaggtgtc tggaagtccc gggaggtagc caccgagggc 360
atccgtgggc accgcaaaat ggtcctctac accctgcggg caccacgaag ccccaagatg 420
gtgcaagggt ctggctgctt tgggaggaag atggaccgga tcagctcctc cagtggcctg 480
ggctgcaaag tgctgaggcg gcattaagag gaagtcctgg ctgcagacac ctgcttctga 540
ttccacaagg ggctttttcc tcaaccctgt ggccgccttt gaagtgactc atttttttaa 600
tgtatttatg tatttatttg attgttttat ataagatggt ttcttacctt tgagcacaaa 660
atttccacgg tgaaataaag tcaacattat aagctttaaa aaaaaaaa 708
<210> 1290
<211> 1935
<212> PRT
<213> Rattus norvegicus (褐家鼠)
<400> 1290
Met Ala Asp Arg Glu Met Ala Ala Phe Gly Ala Gly Ala Pro Phe Leu
1 5 10 15
Arg Lys Ser Glu Lys Glu Arg Leu Glu Ala Gln Thr Arg Pro Phe Asp
20 25 30
Leu Lys Lys Asp Val Phe Val Pro Asp Asp Lys Glu Glu Phe Val Lys
35 40 45
Ala Lys Ile Val Ser Arg Glu Gly Gly Lys Val Thr Ala Glu Thr Glu
50 55 60
Asn Gly Lys Thr Val Thr Val Lys Glu Asp Gln Val Met Gln Gln Asn
65 70 75 80
Pro Pro Lys Phe Asp Lys Ile Glu Asp Met Ala Met Leu Thr Phe Leu
85 90 95
His Glu Pro Ala Val Leu Tyr Asn Leu Lys Glu Arg Tyr Ala Ser Trp
100 105 110
Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro Tyr
115 120 125
Lys Trp Leu Pro Val Tyr Asn Ala Gln Val Val Ala Ala Tyr Arg Gly
130 135 140
Lys Lys Arg Ser Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp Asn
145 150 155 160
Ala Tyr Gln Tyr Met Leu Thr Asp Arg Glu Asn Gln Ser Ile Leu Ile
165 170 175
Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys Arg Val Ile
180 185 190
Gln Tyr Phe Ala Val Ile Ala Ala Ile Gly Asp Arg Ser Lys Lys Asp
195 200 205
Gln Thr Pro Gly Lys Gly Thr Leu Glu Asp Gln Ile Ile Gln Ala Asn
210 215 220
Pro Ala Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg Asn Asp Asn
225 230 235 240
Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly Ala Thr Gly
245 250 255
Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu Lys Ser Arg
260 265 270
Val Ile Phe Gln Leu Lys Ala Glu Arg Asp Tyr His Ile Phe Tyr Gln
275 280 285
Ile Leu Ser Asn Lys Lys Pro Glu Leu Leu Asp Met Leu Leu Ile Thr
290 295 300
Asn Asn Pro Tyr Asp Tyr Ala Phe Phe Ser Gln Gly Glu Thr Thr Val
305 310 315 320
Ala Ser Ile Asp Asp Ser Glu Glu His Met Ala Thr Asp Ser Ala Phe
325 330 335
Asp Val Leu Gly Phe Thr Pro Glu Glu Lys Asn Ser Ile Tyr Lys Leu
340 345 350
Thr Gly Ala Ile Met His Phe Gly Asn Met Lys Phe Lys Gln Lys Gln
355 360 365
Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Glu Ala Asp Lys Ser
370 375 380
Ala Tyr Leu Met Gly Leu Asn Ser Ala Asp Leu Leu Lys Gly Leu Cys
385 390 395 400
His Pro Arg Val Lys Val Gly Asn Glu Tyr Val Thr Lys Gly Gln Asn
405 410 415
Val Gln Gln Val Ala Tyr Ala Ile Gly Ala Leu Ala Lys Ser Val Tyr
420 425 430
Glu Lys Met Phe Asn Trp Met Val Thr Arg Ile Asn Ala Thr Leu Glu
435 440 445
Thr Lys Gln Pro Arg Gln Tyr Phe Ile Gly Val Leu Asp Ile Ala Gly
450 455 460
Phe Glu Ile Phe Asp Phe Asn Ser Phe Glu Gln Leu Cys Ile Asn Phe
465 470 475 480
Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met Phe Val Leu
485 490 495
Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Thr Phe Ile Asp
500 505 510
Phe Gly Met Asp Leu Gln Ala Cys Ile Asp Leu Ile Glu Lys Pro Met
515 520 525
Gly Ile Met Ser Ile Leu Glu Glu Glu Cys Met Phe Pro Lys Ala Thr
530 535 540
Asp Met Thr Phe Lys Ala Lys Leu Tyr Asp Asn His Leu Gly Lys Ser
545 550 555 560
Asn Asn Phe Gln Lys Pro Arg Asn Ile Lys Gly Lys Gln Glu Ala His
565 570 575
Phe Ser Leu Ile His Tyr Ala Gly Thr Val Asp Tyr Asn Ile Leu Gly
580 585 590
Trp Leu Gln Lys Asn Lys Asp Pro Leu Asn Glu Thr Val Val Gly Leu
595 600 605
Tyr Gln Lys Ser Ser Leu Lys Leu Leu Ser Asn Leu Phe Ala Asn Tyr
610 615 620
Ala Gly Ala Asp Ala Pro Val Asp Lys Gly Lys Gly Lys Ala Lys Lys
625 630 635 640
Gly Ser Ser Phe Gln Thr Val Ser Ala Leu His Arg Glu Asn Leu Asn
645 650 655
Lys Leu Met Thr Asn Leu Arg Ser Thr His Pro His Phe Val Arg Cys
660 665 670
Ile Ile Pro Asn Glu Thr Lys Ser Pro Gly Val Met Asp Asn Pro Leu
675 680 685
Val Met His Gln Leu Arg Cys Asn Gly Val Leu Glu Gly Ile Arg Ile
690 695 700
Cys Arg Lys Gly Phe Pro Asn Arg Ile Leu Tyr Gly Asp Phe Arg Gln
705 710 715 720
Arg Tyr Arg Ile Leu Asn Pro Ala Ala Ile Pro Glu Gly Gln Phe Ile
725 730 735
Asp Ser Arg Lys Gly Ala Glu Lys Leu Leu Gly Ser Leu Asp Ile Asp
740 745 750
His Asn Gln Tyr Lys Phe Gly His Thr Lys Val Phe Phe Lys Ala Gly
755 760 765
Leu Leu Gly Leu Leu Glu Glu Met Arg Asp Glu Arg Leu Ser Arg Ile
770 775 780
Ile Thr Arg Ile Gln Ala Gln Ser Arg Gly Val Leu Ser Arg Met Glu
785 790 795 800
Phe Lys Lys Leu Leu Glu Arg Arg Asp Ser Leu Leu Ile Ile Gln Trp
805 810 815
Asn Ile Arg Ala Phe Met Gly Val Lys Asn Trp Pro Trp Met Lys Leu
820 825 830
Tyr Phe Lys Ile Lys Pro Leu Leu Lys Ser Ala Glu Thr Glu Lys Glu
835 840 845
Met Ala Asn Met Lys Glu Glu Phe Gly Arg Val Lys Asp Ala Leu Glu
850 855 860
Lys Ser Glu Ala Arg Arg Lys Glu Leu Glu Glu Lys Met Val Ser Leu
865 870 875 880
Leu Gln Glu Lys Asn Asp Leu Gln Leu Gln Val Gln Ala Glu Gln Asp
885 890 895
Asn Leu Ala Asp Ala Glu Glu Arg Cys Asp Gln Leu Ile Lys Asn Lys
900 905 910
Ile Gln Leu Glu Ala Lys Val Lys Glu Met Thr Glu Arg Leu Glu Asp
915 920 925
Glu Glu Glu Met Asn Ala Glu Leu Thr Ala Lys Lys Arg Lys Leu Glu
930 935 940
Asp Glu Cys Ser Glu Leu Lys Arg Asp Ile Asp Asp Leu Glu Leu Thr
945 950 955 960
Leu Ala Lys Val Glu Lys Glu Lys His Ala Thr Glu Asn Lys Val Lys
965 970 975
Asn Leu Thr Glu Glu Met Ala Gly Leu Asp Glu Ile Ile Val Lys Leu
980 985 990
Thr Lys Glu Lys Lys Ala Leu Gln Glu Ala His Gln Gln Ala Leu Asp
995 1000 1005
Asp Leu Gln Ala Glu Glu Asp Lys Val Asn Thr Leu Thr Lys Ala
1010 1015 1020
Lys Val Lys Leu Glu Gln Gln Val Asp Asp Leu Glu Gly Ser Leu
1025 1030 1035
Asp Gln Asp Lys Lys Val Arg Met Asp Leu Glu Arg Ala Lys Arg
1040 1045 1050
Lys Leu Glu Gly Asp Leu Lys Leu Thr Gln Glu Ser Ile Met Asp
1055 1060 1065
Leu Glu Asn Asp Lys Gln Gln Leu Asp Glu Arg Leu Lys Lys Lys
1070 1075 1080
Asp Phe Glu Leu Asn Ala Leu Asn Ala Arg Ile Glu Asp Glu Gln
1085 1090 1095
Ala Leu Gly Ser Gln Leu Gln Lys Lys Leu Lys Glu Leu Gln Ala
1100 1105 1110
Arg Ile Glu Glu Leu Glu Glu Glu Leu Glu Ala Glu Arg Thr Ala
1115 1120 1125
Arg Ala Lys Val Glu Lys Leu Arg Ser Asp Leu Ser Arg Glu Leu
1130 1135 1140
Glu Glu Ile Ser Glu Arg Leu Glu Glu Ala Gly Gly Ala Thr Ser
1145 1150 1155
Val Gln Ile Glu Met Asn Lys Lys Arg Glu Ala Glu Phe Gln Lys
1160 1165 1170
Met Arg Arg Asp Leu Glu Glu Ala Thr Leu Gln His Glu Ala Thr
1175 1180 1185
Ala Ala Ala Leu Arg Lys Lys His Ala Asp Ser Val Ala Glu Leu
1190 1195 1200
Gly Glu Gln Ile Asp Asn Leu Gln Arg Val Lys Gln Lys Leu Glu
1205 1210 1215
Lys Glu Lys Ser Glu Phe Lys Leu Glu Leu Asp Asp Val Thr Ser
1220 1225 1230
Asn Met Glu Gln Ile Ile Lys Ala Lys Ala Asn Leu Glu Lys Met
1235 1240 1245
Cys Arg Thr Leu Glu Asp Gln Met Asn Glu His Arg Ser Lys Ala
1250 1255 1260
Glu Glu Thr Gln Arg Ser Val Asn Asp Leu Thr Arg Gln Arg Ala
1265 1270 1275
Lys Leu Gln Thr Glu Asn Gly Glu Leu Ser Arg Gln Leu Asp Glu
1280 1285 1290
Lys Glu Ala Leu Ile Ser Gln Leu Thr Arg Gly Lys Leu Thr Tyr
1295 1300 1305
Thr Gln Gln Leu Glu Asp Leu Lys Arg Gln Leu Glu Glu Glu Val
1310 1315 1320
Lys Ala Lys Asn Ala Leu Ala His Ala Leu Gln Ser Ala Arg His
1325 1330 1335
Asp Cys Asp Leu Leu Arg Glu Gln Tyr Glu Glu Glu Thr Glu Ala
1340 1345 1350
Lys Ala Glu Leu Gln Arg Val Leu Ser Lys Ala Asn Ser Glu Val
1355 1360 1365
Ala Gln Trp Arg Thr Lys Tyr Glu Thr Asp Ala Ile Gln Arg Thr
1370 1375 1380
Glu Glu Leu Glu Glu Ala Lys Lys Lys Leu Ala Gln Arg Leu Gln
1385 1390 1395
Asp Ala Glu Glu Ala Val Glu Ala Val Asn Ala Lys Cys Ser Ser
1400 1405 1410
Leu Glu Lys Thr Lys His Arg Leu Gln Asn Glu Ile Glu Asp Leu
1415 1420 1425
Met Val Asp Val Glu Arg Ser Asn Ala Ala Ala Ala Ala Leu Asp
1430 1435 1440
Lys Lys Gln Arg Asn Phe Asp Lys Ile Leu Val Glu Trp Lys Gln
1445 1450 1455
Lys Tyr Glu Glu Ser Gln Ser Glu Leu Glu Ser Ser Gln Lys Glu
1460 1465 1470
Ala Arg Ser Leu Ser Thr Glu Leu Phe Lys Leu Lys Asn Ala Tyr
1475 1480 1485
Glu Glu Ser Leu Glu His Leu Glu Thr Phe Lys Arg Glu Asn Lys
1490 1495 1500
Asn Leu Gln Glu Glu Ile Ser Asp Leu Thr Glu Gln Leu Gly Ser
1505 1510 1515
Thr Gly Lys Ser Ile His Glu Leu Glu Lys Ile Arg Lys Gln Leu
1520 1525 1530
Glu Ala Glu Lys Leu Glu Leu Gln Ser Ala Leu Glu Glu Ala Glu
1535 1540 1545
Ala Ser Leu Glu His Glu Glu Gly Lys Ile Leu Arg Ala Gln Leu
1550 1555 1560
Glu Phe Asn Gln Ile Lys Ala Glu Ile Glu Arg Lys Leu Ala Glu
1565 1570 1575
Lys Asp Glu Glu Met Glu Gln Ala Lys Arg Asn His Leu Arg Val
1580 1585 1590
Val Asp Ser Leu Gln Thr Ser Leu Asp Ala Glu Thr Arg Ser Arg
1595 1600 1605
Asn Glu Ala Leu Arg Val Lys Lys Lys Met Glu Gly Asp Leu Asn
1610 1615 1620
Glu Met Glu Ile Gln Leu Ser His Ala Asn Arg Met Ala Ala Glu
1625 1630 1635
Ala Gln Lys Gln Val Lys Ser Leu Gln Ser Leu Leu Lys Asp Thr
1640 1645 1650
Gln Ile Gln Leu Asp Asp Ala Val Arg Ala Asn Asp Asp Leu Lys
1655 1660 1665
Glu Asn Ile Ala Ile Val Glu Arg Arg Asn Asn Leu Leu Gln Ala
1670 1675 1680
Glu Leu Glu Glu Leu Arg Ala Val Val Glu Gln Thr Glu Arg Ser
1685 1690 1695
Arg Lys Leu Ala Glu Gln Glu Leu Ile Glu Thr Ser Glu Arg Val
1700 1705 1710
Gln Leu Leu His Ser Gln Asn Thr Ser Leu Ile Asn Gln Lys Lys
1715 1720 1725
Lys Met Asp Ala Asp Leu Ser Gln Leu Gln Thr Glu Val Glu Glu
1730 1735 1740
Ala Val Gln Glu Cys Arg Asn Ala Glu Glu Lys Ala Lys Lys Ala
1745 1750 1755
Ile Thr Asp Ala Ala Met Met Ala Glu Glu Leu Lys Lys Glu Gln
1760 1765 1770
Asp Thr Ser Ala His Leu Glu Arg Met Lys Asn Asn Met Glu Gln
1775 1780 1785
Thr Ile Lys Asp Leu Gln His Arg Leu Asp Glu Ala Glu Gln Ile
1790 1795 1800
Ala Leu Lys Gly Gly Lys Lys Gln Leu Gln Lys Leu Glu Ala Arg
1805 1810 1815
Val Arg Glu Leu Glu Asn Glu Leu Glu Ala Glu Gln Lys Arg Asn
1820 1825 1830
Ala Glu Ser Val Lys Gly Met Arg Lys Ser Glu Arg Arg Ile Lys
1835 1840 1845
Glu Leu Thr Tyr Gln Thr Glu Glu Asp Arg Lys Asn Leu Leu Arg
1850 1855 1860
Leu Gln Asp Leu Val Asp Lys Leu Gln Leu Lys Val Lys Ala Tyr
1865 1870 1875
Lys Arg Gln Ala Glu Glu Ala Glu Glu Gln Ala Asn Thr Asn Leu
1880 1885 1890
Ser Lys Phe Arg Lys Val Gln His Glu Leu Asp Glu Ala Glu Glu
1895 1900 1905
Arg Ala Asp Ile Ala Glu Ser Gln Val Asn Lys Leu Arg Ala Lys
1910 1915 1920
Ser Arg Asp Ile Gly Ala Lys Gly Leu Asn Glu Glu
1925 1930 1935
<210> 1291
<211> 5923
<212> DNA
<213> Rattus norvegicus (褐家鼠)
<400> 1291
gctcagtcat ggcggatcga gagatggctg catttggggc cggagccccc ttcctgcgaa 60
aatctgagaa ggagcggctg gaggcgcaga ccaggccctt tgacctcaag aaagatgttt 120
ttgtgcctga tgacaaagaa gagtttgtca aggccaagat cgtgtctcga gagggtggca 180
aagtcaccgc tgagacagag aatggcaaga cggtgactgt gaaggaggac caggtgatgc 240
agcagaaccc tcccaagttc gacaagatcg aggacatggc catgctgacc ttcctgcacg 300
agccggctgt gctctacaat ctcaaggaga ggtacgcttc ctggatgatc tacacctact 360
caggcctctt ctgtgtcacc gtcaacccct ataagtggct gccagtgtac aatgcgcaag 420
tggtagctgc ctaccggggc aagaagagga gcgaggctcc accccacatc ttctccatct 480
ctgacaacgc ctatcagtac atgctgacag atcgggagaa ccagtccatc ctcatcaccg 540
gagaatccgg agctggtaag accgtcaaca ccaagagggt catccaatat tttgctgtta 600
ttgctgccat tggggaccgc agcaagaagg accagacccc aggcaagggc accttggaag 660
atcaaatcat ccaagccaac cccgctctgg aggcctttgg caatgccaag acagttcgga 720
atgataactc ctcccgattt gggaaattca ttcgaatcca ttttggggca acaggaaagt 780
tggcatctgc agatatagag acctaccttc tggaaaaatc cagagttatt ttccagctga 840
aagcagaaag agattatcac attttctacc aaatcctgtc taataaaaag cctgagcttc 900
tagacatgct gctgatcacc aacaacccct acgattatgc gttcttctcc cagggagaga 960
cgactgtggc ctcaatagat gactctgaag agcacatggc caccgatagc gcctttgatg 1020
tgctgggctt cactccagaa gagaagaact ccatttacaa gctgacaggc gccatcatgc 1080
actttggaaa catgaagttc aaacagaagc agagggagga gcaggcagag ccagacggca 1140
cggaagaagc tgacaagtca gcctacctca tgggactgaa ctcggctgac ctgctcaagg 1200
ggttgtgcca ccctcgagtc aaagtgggca acgagtatgt caccaaaggg cagaatgtcc 1260
agcaggtggc atatgccatc ggggcactgg ccaagtcagt gtacgagaag atgttcaact 1320
ggatggtgac acgcatcaac gcaaccctgg agaccaagca gccacgccag tacttcatag 1380
gtgtcctgga catcgccggc tttgagatct ttgatttcaa cagctttgag cagctgtgca 1440
tcaacttcac caatgagaag ctgcagcagt tcttcaacca ccacatgttc gtgctggagc 1500
aggaggagta caagaaggaa ggcatcgagt ggacgtttat tgacttcggc atggacctgc 1560
aggcctgcat cgacctcatc gagaagccca tgggcatcat gtccatcctg gaggaggagt 1620
gcatgttccc caaggccacg gacatgacct tcaaggccaa gctgtacgac aaccacctgg 1680
gcaagtccaa caacttccag aagcctcgca atatcaaggg aaagcaggaa gcccacttct 1740
ctctgatcca ctatgctggc accgtggact acaatatcct gggctggcta cagaagaaca 1800
aggaccctct caatgagacg gtggtggggc tgtaccagaa gtcctccctc aagctcctaa 1860
gtaatctgtt tgccaactat gctggagctg atgcacctgt agacaagggc aaaggcaaag 1920
caaagaaagg ctcatccttt cagaccgtgt ccgcactgca cagggaaaat ctgaacaaac 1980
ttatgacaaa cctgcgctcc acgcaccctc actttgtacg ctgcatcatc cccaatgaga 2040
cgaagtctcc aggggtgatg gacaaccccc tggtcatgca ccagctgcga tgcaacggag 2100
tgctggaggg tatccgcatc tgtaggaagg gcttccccaa ccgcattctt tatggggact 2160
tccggcagag gtatcgaatc ctgaacccag cagccatccc tgagggccaa ttcattgata 2220
gccggaaagg ggctgagaag ctgctgggct ccctggacat tgaccacaac cagtacaagt 2280
ttggccacac caaggtgttc ttcaaggcgg ggctgctggg gctgctggag gagatgcgag 2340
atgagaggct gagccgcatc atcaccagaa tccaggccca gtcccgaggt gtactttcca 2400
gaatggagtt taagaagctg ctggagcgca gagactccct gctgattatc cagtggaaca 2460
tccgcgcctt catgggggtc aagaattggc cgtggatgaa gctctacttc aagatcaagc 2520
cgctgctgaa gagcgcagag acagagaagg agatggccaa catgaaggag gagttcgggc 2580
gagtcaaaga tgcactagag aagtctgagg ctcgccgcaa ggagctggag gagaagatgg 2640
tgtccctgct gcaggagaag aatgacctgc agctccaagt gcaggcggaa caagacaacc 2700
tggcagatgc cgaggagcgc tgcgaccagc tgatcaagaa caagatccag ctggaggcca 2760
aggtgaagga gatgaccgag aggctggagg acgaggagga gatgaacgcc gagctcacgg 2820
ccaagaagcg caaactggaa gacgagtgct cagagctcaa gagagatatc gatgacctgg 2880
agctgaccct ggccaaggtg gagaaggaaa agcacgcaac agagaacaag gtgaaaaacc 2940
tgacagagga gatggctggg ctggacgaga tcattgtcaa gctgaccaag gagaagaaag 3000
ctctacaaga ggcccaccag caagccctag atgaccttca ggctgaggag gacaaggtca 3060
acactctgac caaggccaag gtcaagctgg agcagcaagt ggatgatctg gagggatccc 3120
tggatcagga caagaaggtg cgcatggacc tggagcgagc aaagcggaag ctggagggtg 3180
acctgaagct gacccaggag agcatcatgg acctggagaa cgacaagcag cagttggatg 3240
agcgactcaa aaagaaggac tttgagttaa atgcactcaa cgccaggatt gaggatgagc 3300
aggccctggg cagccagctg cagaagaagc tcaaagagct tcaggcacgc atcgaggagc 3360
tggaggagga gctggaggct gagcgcacag cccgggccaa ggtggagaag ctgcgctcag 3420
acctgtcccg ggagctggag gagatcagtg agaggctaga ggaagccggt ggggccacat 3480
ctgtgcagat agagatgaac aagaagcgcg aggccgagtt ccagaagatg cggcgggacc 3540
tagaggaggc cacgctgcag catgaggcca cagctgcggc cctgcgcaag aaacacgcgg 3600
acagcgtggc cgagctgggc gagcagatag acaatctaca gcgggtgaag cagaagctgg 3660
agaaagagaa gagcgagttc aagctggagc tggatgacgt tacctccaac atggagcaga 3720
tcatcaaggc caaggctaac ctggagaaga tgtgccggac cctggaggac cagatgaatg 3780
aacaccggag caaggctgag gagacacagc gttctgtcaa tgacctcacc cgccagcggg 3840
ccaagctgca gacagagaat ggggagctgt ccagacagct ggatgagaag gaggctctta 3900
tctctcagct gacccgaggc aagctcacgt atacccagca gctggaggac ctcaagaggc 3960
agctggagga ggaggtcaag gccaagaatg ccctggccca cgcactgcag tcagcccggc 4020
atgattgcga cctgctgcgg gaacagtacg aggaggaaac agaagccaag gctgagctgc 4080
agcgtgtcct gtccaaggcc aactcagagg tggcccagtg gaggaccaag tatgagacgg 4140
acgccataca gaggacggag gagctggagg aagccaagaa gaagctggct cagaggcttc 4200
aggatgctga ggaggcagtg gaggccgtca acgccaagtg ctcctcgctg gagaagacca 4260
agcacaggct gcagaacgag atcgaggacc tgatggtgga tgtggagcgc tccaatgcgg 4320
ccgccgcagc cctggacaag aagcagagga acttcgacaa gatcctggtt gagtggaagc 4380
agaagtatga ggagtcccag tcagagctgg agtcttccca gaaggaggcg cgctccctga 4440
gcacagagct cttcaagctg aagaatgcct atgaggagtc tctggagcac ctggagacct 4500
tcaagcggga gaacaagaac ctccaggagg agatctcaga cctgactgaa cagctgggct 4560
caactgggaa gagcatccac gagctggaga agatccgaaa gcaactggag gctgagaagc 4620
tggagctgca gtcagccctg gaagaggctg aggcctccct ggagcatgag gagggcaaga 4680
tcctccgagc ccagctggag ttcaaccaga tcaaggcaga gatcgaaagg aagctggcag 4740
agaaggacga ggagatggag caggccaagc gcaaccacct gcgggtggtg gactccctgc 4800
agacctccct ggatgccgag acgcgcagcc gcaacgaggc cctgcgggtg aagaagaaga 4860
tggagggcga cctcaacgag atggagatcc agctcagtca tgccaaccgc atggctgctg 4920
aggcccagaa acaagtgaag agcctccaga gtttgctgaa ggacactcaa atccagctgg 4980
atgacgcagt ccgtgccaat gacgacctga aggagaacat cgccatcgtg gagcggcgca 5040
acaacctgct gcaggcggag ctggaggagc tgcgggccgt ggtggagcag acggagcggt 5100
ctcggaagct ggcagagcag gagctgatcg agaccagcga gcgggtgcag ctgctgcact 5160
cccagaacac cagcctcatc aaccagaaga agaagatgga tgcagacctc tcccagctcc 5220
agacagaggt ggaggaggcg gtgcaggagt gtaggaacgc agaggagaag gccaagaagg 5280
ccatcacaga tgccgccatg atggccgagg agctgaagaa ggagcaggac accagcgccc 5340
acctggagcg catgaagaat aacatggagc agaccatcaa ggacctgcag caccggctgg 5400
acgaggcaga gcagatcgcc ctcaagggtg gcaagaagca gctgcagaag ctggaggccc 5460
gggtccggga gctggagaat gagctggagg ctgagcagaa gcgcaatgcg gagtcggtga 5520
agggcatgag gaagagcgag cggcgcatca aggagctcac ctaccagaca gaggaagaca 5580
ggaagaacct actgcgactg caggacctgg tggacaagct gcagttaaag gtgaaggcct 5640
acaagcgcca ggctgaggag gcggaggaac aggccaacac caacctgtcc aagttccgca 5700
aggtgcagca cgagctggat gaggcagagg agagggcgga cattgccgag tcccaggtca 5760
acaagctgcg ggccaagagc cgtgacattg gcgccaaggg cctgaatgaa gagtagatct 5820
tgtgctaccc aaccctaagg atgcctgtga agccctgaga cctggagcct ttgaaacagc 5880
accttaggca gaaacacaat aaagcaattt tccttcaagc caa 5923
<210> 1292
<211> 21
<212> DNA
<213> Homo sapiens (智人)
<400> 1292
ggaaatccct ggcaatgtga t 21
<210> 1293
<211> 20
<212> DNA
<213> Homo sapiens (智人)
<400> 1293
tgttgtttgg cttttcctgt 20
<210> 1294
<211> 20
<212> DNA
<213> Homo sapiens (智人)
<400> 1294
ttagattgaa acaacccagt 20
<210> 1295
<211> 13
<212> DNA
<213> Homo sapiens (智人)
<400> 1295
atctggtgtt att 13
<210> 1296
<211> 14
<212> DNA
<213> Homo sapiens (智人)
<400> 1296
gagatctggt gtta 14
<210> 1297
<211> 13
<212> DNA
<213> Homo sapiens (智人)
<400> 1297
ctggtgttat tga 13
<210> 1298
<211> 14
<212> DNA
<213> Homo sapiens (智人)
<400> 1298
gatctggtgt tatt 14
<210> 1299
<211> 16
<212> DNA
<213> Homo sapiens (智人)
<400> 1299
agaagcaggt gtctgc 16
<210> 1300
<211> 16
<212> DNA
<213> Homo sapiens (智人)
<400> 1300
gaatcagaag caggtg 16
<210> 1301
<211> 16
<212> DNA
<213> Homo sapiens (智人)
<400> 1301
aagcaggtgt ctgcag 16
<210> 1302
<211> 15
<212> DNA
<213> Homo sapiens (智人)
<400> 1302
atcagaagca ggtgt 15
<210> 1303
<211> 15
<212> DNA
<213> Homo sapiens (智人)
<400> 1303
tgtggaatca gaagc 15
<210> 1304
<211> 16
<212> DNA
<213> Homo sapiens (智人)
<400> 1304
ggccacaggg ttgagg 16
<210> 1305
<211> 15
<212> DNA
<213> Homo sapiens (智人)
<400> 1305
agggttgagg aaaaa 15
<210> 1306
<211> 16
<212> DNA
<213> Homo sapiens (智人)
<400> 1306
cttgatctgc tcagcc 16
<210> 1307
<211> 16
<212> DNA
<213> Homo sapiens (智人)
<400> 1307
atcttgatct gctcag 16

Claims (9)

1.一种条件性RNA-传感器复合物，包括：
包含至少一个支点片段的传感器链，其中，该支点片段与靶细胞中存在或过表达的病理性生物标志物结合，所述靶细胞为心肌细胞；
一个双链pro-RNA分子，包括
向导链，包含一个与靶细胞中的治疗性靶分子结合的RNA分子；以及
一个核心链，包括
一个第一部分，包含与所述向导链完全或部分互补并与该向导链结合的乘客链；
一个第二部分，包含与所述传感器链完全或部分互补并与该传感器链结合的第一保护片段；和
一个第一接头，其将所述乘客链的第一端与所述第一保护片段连接；和
一个第三部分，所述第三部分包括与所述传感器链完全或部分互补并结合的第二保护片段，以及将所述乘客链的第二端连接到所述第二保护片段的第二接头；
其中，所述病理性生物标志物是mRNA分子或miRNA分子，并且编码ANP，BNP，MHCβ，或mir-23a-3p的至少一部分；
其中，所述双链pro-RNA分子是RNA干扰(RNAi)分子，且所述治疗性靶分子是编码钙调磷酸酶或组蛋白脱乙酰化酶2(HDAC2)的至少一部分的RNA分子；其中，
(a)所述传感器链的序列如SEQ ID NO:4所示，
所述核心链包含SEQ ID NOS:21，49，50的序列，
其中，从5’至3’，所述SEQ ID NO:21的序列通过所述第一接头连接到SEQ ID NO:49的序列，并且所述SEQ ID NO:49的序列通过所述第二接头连接到SEQ ID NO:50的序列；且
所述导向链的序列如SEQ ID NO:15所示，或
(b)所述传感器链的序列如SEQ ID NO:5所示，
所述核心链包含SEQ ID NOS:22，49，51的序列，
其中，从5’至3’，所述SEQ ID NO:22的序列通过所述第一接头连接到SEQ ID NO:49的序列，并且所述SEQ ID NO:49的序列通过所述第二接头连接到SEQ ID NO:51的序列；且
所述导向链的序列如SEQ ID NO:15所示；或
(c)所述传感器链的序列如SEQ ID NO:6所示，
所述核心链包含SEQ ID NOS:23，49，52的序列，
其中，从5’至3’，所述SEQ ID NO:23的序列通过所述第一接头连接到SEQ ID NO:49的序列，并且所述SEQ ID NO:49的序列通过所述第二接头连接到SEQ ID NO:52的序列；且
所述导向链的序列如SEQ ID NO:15所示；或
(d)所述传感器链的序列如SEQ ID NO:7所示，
所述核心链包含SEQ ID NOS:24，49，53的序列；
其中，从5’至3’，所述SEQ ID NO:24的序列通过所述第一接头连接到SEQ ID NO:49的序列，并且所述SEQ ID NO:49的序列通过所述第二接头连接到SEQ ID NO:53的序列；且
所述导向链的序列如SEQ ID NO:15所示；或
(e)所述传感器链的序列如SEQ ID NO:8所示，
所述核心链的序列如SEQ ID NO:25所示，且
所述导向链的序列如SEQ ID NO:16所示；或
(f)所述传感器链的序列如SEQ ID NO:8所示，
所述核心链包含SEQ ID NOS:18，45，47的序列，
其中，从5’至3’，所述SEQ ID NO:18的序列通过所述第一接头连接到SEQ ID NO:45的序列，并且所述SEQ ID NO:45的序列通过所述第二接头连接到SEQ ID NO:47的序列；且
所述导向链是SEQ ID NO:11的序列；或
(g)所述传感器链的序列如SEQ ID NO:10所示，
所述核心链包含SEQ ID NOS:19，45，48的序列；
其中，从5’至3’，所述SEQ ID NO:19的序列通过所述第一接头连接到SEQ ID NO:45的序列，并且所述SEQ ID NO:45的序列通过所述第二接头连接到SEQ ID NO:48的序列；且
所述导向链的序列如SEQ ID NO:12所示；或
(h)所述传感器链的序列如SEQ ID NO:1所示，
所述核心链包含SEQ ID NOS:41，45，56的序列；
其中，从5’至3’，所述SEQ ID NO:41的序列通过所述第一接头连接到SEQ ID NO:45的序列，并且所述SEQ ID NO:45的序列通过所述第二接头连接到SEQ ID NO:56的序列；且
所述导向链的序列如SEQ ID NO:12的序列；或
(i)所述传感器链的序列如SEQ ID NO:2所示，
所述核心链包含SEQ ID NOS:41，45，56的序列，
其中，从5’至3’，所述SEQ ID NO:41的序列通过所述第一接头连接到SEQ ID NO:45的序列，并且所述SEQ ID NO:45的序列通过所述第二接头连接到SEQ ID NO:56的序列；且
所述导向链的序列如SEQ ID NO:12所示；或
(j)所述传感器链的序列如SEQ ID NO:39所示，
所述核心链包含SEQ ID NOS:41，45，56的序列，
其中，从5’至3’，所述SEQ ID NO:41的序列通过所述第一接头连接到SEQ ID NO:45的序列，并且所述SEQ ID NO:45的序列通过所述第二接头连接到SEQ ID NO:56的序列；且
所述导向链的序列如SEQ ID NO:12所示。
2.如权利要求1所述的条件性RNA-传感器复合物，其中所述支点片段是适配子。
3.如权利要求1或2所述的条件性RNA-传感器复合物，其中，当所述病理性生物标志物与所述支点片段结合时所述传感器链从所述双链pro-RNA分子上被置换下，且所得的双链pro-RNA分子是Dicer的底物。
4.如权利要求1或2所述的条件性RNA-传感器复合物，其中，所述mRNA分子或miRNA分子包含与选自SEQ ID NOs:1-2、4-8、10和39的序列至少75％互补的序列。
5.如权利要求1或2所述的条件性RNA-传感器复合物，其中，所述第一接头，所述第二接头，或第一和第二接头这两者均为C3间隔子。
6.如权利要求1或2所述的条件性RNA-传感器复合物，其中，所述传感器链，所述向导链和/或所述核心链还包括对RNA序列的一个或多个化学修饰，其中，所述一个或多个化学修饰选自锁核酸(LNA)修饰，肽核酸(PNA)修饰，2'-O-甲基修饰，吗啉代修饰，硫代磷酸酯修饰，末端修饰，或接头修饰。
7.一种药学组合物，包含：
一种权利要求1-6中任一项所述的条件性RNA-传感器复合物；以及
一种药学上可接受的载体或赋形剂。
8.权利要求1-6中任一项所述的条件性RNA-传感器复合物或权利要求7所述的药学组合物在制备用于治疗心肌梗塞(MI)或心肌肥大的药物中的用途，其中所述用途包括向患有病理性病症的受试者施用治疗有效量的所述条件性RNA-传感器复合物或所述药学组合物。
9.如权利要求8所述的用途，其中，施用治疗有效量包括在检测到MI后心肌内注射所述条件性RNA-传感器复合物或所述药学组合物。
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