WO2007090071A2 - 6-modified bicyclic nucleic acid analogs - Google Patents

6-modified bicyclic nucleic acid analogs Download PDF

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Publication number
WO2007090071A2
WO2007090071A2 PCT/US2007/061183 US2007061183W WO2007090071A2 WO 2007090071 A2 WO2007090071 A2 WO 2007090071A2 US 2007061183 W US2007061183 W US 2007061183W WO 2007090071 A2 WO2007090071 A2 WO 2007090071A2
Authority
WO
WIPO (PCT)
Prior art keywords
oligomeric compound
nucleoside
mmol
compound
substituted
Prior art date
Application number
PCT/US2007/061183
Other languages
English (en)
French (fr)
Other versions
WO2007090071A3 (en
Inventor
Eric E. Swayze
Punit P. Seth
Original Assignee
Isis Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38328111&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2007090071(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Isis Pharmaceuticals, Inc. filed Critical Isis Pharmaceuticals, Inc.
Priority to JP2008552604A priority Critical patent/JP5342881B2/ja
Priority to DK07762892.3T priority patent/DK1984381T3/da
Priority to EP07762892A priority patent/EP1984381B1/en
Priority to KR1020137007796A priority patent/KR20130042043A/ko
Priority to CN2007800105660A priority patent/CN101410406B/zh
Priority to AU2007211080A priority patent/AU2007211080B9/en
Priority to AT07762892T priority patent/ATE482965T1/de
Priority to DE602007009487T priority patent/DE602007009487D1/de
Priority to KR1020087020907A priority patent/KR101304071B1/ko
Priority to PL07762892T priority patent/PL1984381T3/pl
Priority to CA2640171A priority patent/CA2640171C/en
Priority to DK07811872.6T priority patent/DK2021472T3/da
Priority to JP2009510132A priority patent/JP2009536222A/ja
Priority to ES07811873.4T priority patent/ES2471978T3/es
Priority to AU2007257093A priority patent/AU2007257093A1/en
Priority to EP12174138A priority patent/EP2505649A1/en
Priority to AU2007253909A priority patent/AU2007253909B2/en
Priority to EP12174143A priority patent/EP2527442A3/en
Priority to AU2007257094A priority patent/AU2007257094B2/en
Priority to EP12174128A priority patent/EP2505646A1/en
Priority to US12/299,611 priority patent/US20090326041A1/en
Priority to PCT/US2007/068401 priority patent/WO2007146511A2/en
Priority to PCT/US2007/068403 priority patent/WO2007131238A2/en
Priority to EP11160534A priority patent/EP2363482A1/en
Priority to US12/299,768 priority patent/US20090326042A1/en
Priority to EP07811873.4A priority patent/EP2015758B1/en
Priority to JP2009510136A priority patent/JP2009536039A/ja
Priority to EP11189591.8A priority patent/EP2458006B1/en
Priority to US12/299,764 priority patent/US8673871B2/en
Priority to DK07811873.4T priority patent/DK2015758T3/da
Priority to AT07811875T priority patent/ATE513912T1/de
Priority to KR1020087029617A priority patent/KR101441700B1/ko
Priority to EP07811878.3A priority patent/EP2019692B1/en
Priority to JP2009510131A priority patent/JP5825754B2/ja
Priority to CA002651042A priority patent/CA2651042A1/en
Priority to US11/745,429 priority patent/US9045754B2/en
Priority to DK07811878.3T priority patent/DK2019692T3/da
Priority to PCT/US2007/068415 priority patent/WO2007136989A2/en
Priority to JP2009510134A priority patent/JP5372745B2/ja
Priority to EP07811874A priority patent/EP2023939B1/en
Priority to US12/299,572 priority patent/US8143230B2/en
Priority to AT07811872T priority patent/ATE514777T1/de
Priority to PCT/US2007/068408 priority patent/WO2007143317A2/en
Priority to ES07811874T priority patent/ES2386578T3/es
Priority to EP11176633A priority patent/EP2397551A1/en
Priority to AU2007258117A priority patent/AU2007258117B2/en
Priority to US12/299,605 priority patent/US20090292006A1/en
Priority to PCT/US2007/068410 priority patent/WO2007136988A2/en
Priority to EP12174135A priority patent/EP2505648A1/en
Priority to EP07811872A priority patent/EP2021472B1/en
Priority to BRPI0711429-0A priority patent/BRPI0711429A2/pt
Priority to PCT/US2007/068402 priority patent/WO2007131237A2/en
Priority to MX2008014100A priority patent/MX2008014100A/es
Priority to PT78118734T priority patent/PT2015758E/pt
Priority to CA3044969A priority patent/CA3044969A1/en
Priority to PCT/US2007/068404 priority patent/WO2007143315A2/en
Priority to PCT/US2007/068412 priority patent/WO2007134014A2/en
Priority to EP12174139A priority patent/EP2505650A1/en
Priority to EP11160528.3A priority patent/EP2363481B1/en
Priority to US12/299,583 priority patent/US8372967B2/en
Priority to US12/299,607 priority patent/US8586554B2/en
Priority to CA2651309A priority patent/CA2651309C/en
Priority to CN201310168425.9A priority patent/CN103554205A/zh
Priority to DK11160528.3T priority patent/DK2363481T3/en
Priority to PCT/US2007/068406 priority patent/WO2007143316A2/en
Priority to EP07811875A priority patent/EP2023940B1/en
Priority to EP12174131A priority patent/EP2505647A1/en
Priority to DK11189591.8T priority patent/DK2458006T3/en
Priority to JP2009510130A priority patent/JP5731115B2/ja
Publication of WO2007090071A2 publication Critical patent/WO2007090071A2/en
Publication of WO2007090071A3 publication Critical patent/WO2007090071A3/en
Priority to NO20084738A priority patent/NO20084738L/no
Priority to HK09107609.9A priority patent/HK1128418A1/xx
Priority to US12/883,049 priority patent/US8362232B2/en
Priority to US13/457,960 priority patent/US20120208864A1/en
Priority to US13/662,263 priority patent/US8969316B2/en
Priority to JP2013184285A priority patent/JP2014033674A/ja
Priority to US14/216,600 priority patent/US20150057329A1/en
Priority to US14/698,554 priority patent/US9617540B2/en
Priority to JP2015248195A priority patent/JP6272290B2/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PCT/US2007/061183 2006-01-27 2007-01-27 6-modified bicyclic nucleic acid analogs WO2007090071A2 (en)

Priority Applications (78)

Application Number Priority Date Filing Date Title
JP2008552604A JP5342881B2 (ja) 2006-01-27 2007-01-27 ６−修飾された二環式核酸類似体
DK07762892.3T DK1984381T3 (da) 2006-01-27 2007-01-27 6-modificerede bicycliske nukleinsyreanaloger
EP07762892A EP1984381B1 (en) 2006-01-27 2007-01-27 6-modified bicyclic nucleic acid analogs
KR1020137007796A KR20130042043A (ko) 2006-01-27 2007-01-27 6-변형된 바이시클릭 핵산 유사체
CN2007800105660A CN101410406B (zh) 2006-01-27 2007-01-27 6-修饰的双环核酸类似物
AU2007211080A AU2007211080B9 (en) 2006-01-27 2007-01-27 6-modified bicyclic nucleic acid analogs
AT07762892T ATE482965T1 (de) 2006-01-27 2007-01-27 6-modifizierte bicyclische nukleinsäureanaloga
DE602007009487T DE602007009487D1 (de) 2006-01-27 2007-01-27 6-modifizierte bicyclische nukleinsäureanaloga
KR1020087020907A KR101304071B1 (ko) 2006-01-27 2007-01-27 6-변형된 바이시클릭 핵산 유사체
PL07762892T PL1984381T3 (pl) 2006-01-27 2007-01-27 Zmodyfikowane w pozycji 6 analogi bicykliczne kwasów nukleinowych
CA2640171A CA2640171C (en) 2006-01-27 2007-01-27 6-modified bicyclic nucleic acid analogs
DK07811872.6T DK2021472T3 (da) 2006-05-05 2007-05-07 Forbindelser og fremgangsmåder til modulering af genekspression
JP2009510132A JP2009536222A (ja) 2006-05-05 2007-05-07 Ｐｃｓｋ９の発現を調節するための化合物および方法
ES07811873.4T ES2471978T3 (es) 2006-05-05 2007-05-07 Compuestos y procedimientos para modular la expresión de ApoB
AU2007257093A AU2007257093A1 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of PCSK9
EP12174138A EP2505649A1 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of GCGR
AU2007253909A AU2007253909B2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of GCCR
EP12174143A EP2527442A3 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating gene expression
AU2007257094A AU2007257094B2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of SGLT2
EP12174128A EP2505646A1 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of CRP
US12/299,611 US20090326041A1 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of sglt2
PCT/US2007/068401 WO2007146511A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating gene expression
PCT/US2007/068403 WO2007131238A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression apob
EP11160534A EP2363482A1 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating gene expression
US12/299,768 US20090326042A1 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of crp
EP07811873.4A EP2015758B1 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression apob
JP2009510136A JP2009536039A (ja) 2006-05-05 2007-05-07 Ｇｃｃｒの発現を調節するための化合物および方法
EP11189591.8A EP2458006B1 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression APOB
US12/299,764 US8673871B2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression ApoB
DK07811873.4T DK2015758T3 (da) 2006-05-05 2007-05-07 Forbindelser og fremgangsmåder til modulering af ekspression af apob
AT07811875T ATE513912T1 (de) 2006-05-05 2007-05-07 Verbindungen und verfahren zur modulation der expression von sglt2
KR1020087029617A KR101441700B1 (ko) 2006-05-05 2007-05-07 Ｐｃｓｋ９ 발현을 조절하는 화합물 및 방법
EP07811878.3A EP2019692B1 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of gccr
JP2009510131A JP5825754B2 (ja) 2006-05-05 2007-05-07 Ａｐｏｂの発現を調節するための化合物および方法
CA002651042A CA2651042A1 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of sglt2
US11/745,429 US9045754B2 (en) 2006-05-05 2007-05-07 Short antisense compounds with gapmer configuration
DK07811878.3T DK2019692T3 (da) 2006-05-05 2007-05-07 Forbindelser og fremgangsmåder til modulation af ekspression af gccr
PCT/US2007/068415 WO2007136989A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of dgat2
JP2009510134A JP5372745B2 (ja) 2006-05-05 2007-05-07 Ｓｇｌｔ２の発現を調節するための化合物および方法
EP07811874A EP2023939B1 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of pcsk9
US12/299,572 US8143230B2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of PCSK9
AT07811872T ATE514777T1 (de) 2006-05-05 2007-05-07 Verbindungen und verfahren zur modulation von genexpression
PCT/US2007/068408 WO2007143317A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of crp
ES07811874T ES2386578T3 (es) 2006-05-05 2007-05-07 Compuestos y procedimientos para modular la expresión de PCSK9
EP11176633A EP2397551A1 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of PCSK9
AU2007258117A AU2007258117B2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating gene expression
US12/299,605 US20090292006A1 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of dgat2
PCT/US2007/068410 WO2007136988A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of gccr
EP12174135A EP2505648A1 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of PTP1B
EP07811872A EP2021472B1 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating gene expression
BRPI0711429-0A BRPI0711429A2 (pt) 2006-05-05 2007-05-07 compostos e métodos para modulas expressão de gccr
PCT/US2007/068402 WO2007131237A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of ptp1b
MX2008014100A MX2008014100A (es) 2006-05-05 2007-05-07 Compuestos y metodos para modular la expresion de pcsk9.
PT78118734T PT2015758E (pt) 2006-05-05 2007-05-07 Compostos e métodos para modular a expressão da proteína apob
CA3044969A CA3044969A1 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating gene expression
PCT/US2007/068404 WO2007143315A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of pcsk9
PCT/US2007/068412 WO2007134014A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of gcgr
EP12174139A EP2505650A1 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of PCSK9
EP11160528.3A EP2363481B1 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating gene expression
US12/299,583 US8372967B2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of GCCR
US12/299,607 US8586554B2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of PTP1B
CA2651309A CA2651309C (en) 2006-05-05 2007-05-07 Compounds and methods for modulating gene expression
CN201310168425.9A CN103554205A (zh) 2006-05-05 2007-05-07 调节gccr的表达的化合物和方法
DK11160528.3T DK2363481T3 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating gene expression
PCT/US2007/068406 WO2007143316A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of sglt2
EP07811875A EP2023940B1 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of sglt2
EP12174131A EP2505647A1 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of DGAT2
DK11189591.8T DK2458006T3 (en) 2006-05-05 2007-05-07 Compounds and Methods for Modulating ApoB Expression.
JP2009510130A JP5731115B2 (ja) 2006-05-05 2007-05-07 遺伝子発現を調節するための化合物および方法
NO20084738A NO20084738L (no) 2006-05-05 2008-11-10 Forbindelser og fremgangsmater for modulering av ekspresjonen av PCSK9
HK09107609.9A HK1128418A1 (en) 2006-05-05 2009-08-18 Compounds and methods for modulating expression of sglt2
US12/883,049 US8362232B2 (en) 2006-05-05 2010-09-15 Compounds and methods for modulating expression of SGLT2
US13/457,960 US20120208864A1 (en) 2006-05-05 2012-04-27 Compounds and methods for modulating expression of gcgr
US13/662,263 US8969316B2 (en) 2006-05-05 2012-10-26 Compounds and methods for modulating expression of DGAT2
JP2013184285A JP2014033674A (ja) 2006-05-05 2013-09-05 Ａｐｏｂの発現を調節するための化合物および方法
US14/216,600 US20150057329A1 (en) 2006-05-05 2014-03-17 Compounds and methods for modulating expression apob
US14/698,554 US9617540B2 (en) 2006-05-05 2015-04-28 Compounds and methods for modulating gene expression
JP2015248195A JP6272290B2 (ja) 2006-05-05 2015-12-21 Ａｐｏｂの発現を調節するための化合物および方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US76272206P 2006-01-27 2006-01-27
US60/762,722 2006-01-27
US80566006P 2006-06-23 2006-06-23
US60/805,660 2006-06-23

Related Child Applications (13)

Application Number Title Priority Date Filing Date
US11/745,429 Continuation-In-Part US9045754B2 (en) 2006-05-05 2007-05-07 Short antisense compounds with gapmer configuration
US12/299,764 Continuation-In-Part US8673871B2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression ApoB
US12/299,764 Continuation US8673871B2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression ApoB
PCT/US2007/068412 Continuation WO2007134014A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of gcgr
PCT/US2007/068403 Continuation-In-Part WO2007131238A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression apob
US12/299,611 Continuation-In-Part US20090326041A1 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of sglt2
US12/299,607 Continuation-In-Part US8586554B2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of PTP1B
PCT/US2007/068410 Continuation-In-Part WO2007136988A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of gccr
PCT/US2007/068406 Continuation-In-Part WO2007143316A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of sglt2
US12/299,583 Continuation-In-Part US8372967B2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of GCCR
US29960909A Continuation 2006-05-05 2009-01-29
US29958309A Continuation-In-Part 2006-05-05 2009-02-03
US29961109A Continuation-In-Part 2006-05-05 2009-03-11

Publications (2)

Publication Number Publication Date
WO2007090071A2 true WO2007090071A2 (en) 2007-08-09
WO2007090071A3 WO2007090071A3 (en) 2008-01-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/061183 WO2007090071A2 (en) 2006-01-27 2007-01-27 6-modified bicyclic nucleic acid analogs

Country Status (13)

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US (3) US7399845B2 (US07399845-20080715-C00049.png)
EP (3) EP2314594B1 (US07399845-20080715-C00049.png)
JP (2) JP5342881B2 (US07399845-20080715-C00049.png)
KR (2) KR101304071B1 (US07399845-20080715-C00049.png)
CN (2) CN102908630B (US07399845-20080715-C00049.png)
AT (1) ATE482965T1 (US07399845-20080715-C00049.png)
AU (1) AU2007211080B9 (US07399845-20080715-C00049.png)
CA (1) CA2640171C (US07399845-20080715-C00049.png)
DE (1) DE602007009487D1 (US07399845-20080715-C00049.png)
DK (2) DK2314594T3 (US07399845-20080715-C00049.png)
ES (1) ES2516815T3 (US07399845-20080715-C00049.png)
PL (2) PL2314594T3 (US07399845-20080715-C00049.png)
WO (1) WO2007090071A2 (US07399845-20080715-C00049.png)

Cited By (209)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009124295A2 (en) * 2008-04-04 2009-10-08 Isis Pharmaceuticals, Inc. Oligomeric compounds comprising bicyclic nucleosides and having reduced toxicity
WO2010036698A1 (en) * 2008-09-24 2010-04-01 Isis Pharmaceuticals, Inc. Substituted alpha-l-bicyclic nucleosides
WO2010077578A1 (en) * 2008-12-09 2010-07-08 Isis Pharmaceuticals, Inc. Bis-modified bicyclic nucleic acid analogs
WO2010150789A1 (ja) 2009-06-23 2010-12-29 武田薬品工業株式会社 核酸の合成法
US8084437B2 (en) 2006-11-27 2011-12-27 Isis Pharmaceuticals, Inc. Methods for treating hypercholesterolemia
US8093222B2 (en) 2006-11-27 2012-01-10 Isis Pharmaceuticals, Inc. Methods for treating hypercholesterolemia
EP2410053A1 (en) 2006-10-18 2012-01-25 Isis Pharmaceuticals, Inc. Antisense compounds
US8143230B2 (en) 2006-05-05 2012-03-27 Isis Pharmaceuticals, Inc. Compounds and methods for modulating expression of PCSK9
EP2527442A2 (en) * 2006-05-05 2012-11-28 Isis Pharmaceuticals, Inc. Compounds and methods for modulating gene expression
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