US20130338122A1 - Transdermal hormone replacement therapies - Google Patents
Transdermal hormone replacement therapies Download PDFInfo
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- US20130338122A1 US20130338122A1 US13/843,362 US201313843362A US2013338122A1 US 20130338122 A1 US20130338122 A1 US 20130338122A1 US 201313843362 A US201313843362 A US 201313843362A US 2013338122 A1 US2013338122 A1 US 2013338122A1
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
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- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
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- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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Definitions
- This disclosure relates to natural estrogen and progesterone replacement therapies, with transdermal formulations provided for each estrogen and progesterone alone and in combination for the treatment of pre-menopausal, peri-menopausal, menopausal and post-menopausal females in relation to the treatment of estrogen- and progesterone-deficient states, each as herein defined below.
- HRT Hormone replacement therapy
- a group of medications designed to increase hormone levels in women who lack adequate hormone production.
- HRT can mitigate and prevent symptoms caused by diminished circulating estrogen and progesterone hormones regardless as to whether the subject is pre-menopausal, peri-menopausal, menopausal or post-menopausal.
- specific disease states can exist during each stage of menopausal progression.
- HRT via transdermal delivery is presently available in various forms.
- One therapy involves administration of one or more estrogens.
- Progesterone administration acts, in addition to treating other disease states, to mitigate certain undesirable side effects from estrogen administration including, for example, endometrial hyperplasia (thickening), and reducing the incidence of endometrial cancer.
- progesterone both naturally-occurring and bio-identical, is generally collectively referred to herein as “progesterone.”
- progestogen class of hormones for inclusion in transdermal therapies, typically in combination with an estrogen.
- the teachings within such references are generally limited to progestins however.
- Progestins are sometimes confused in the literature with progesterone or progestogens generally.
- progestins are a distinct subclass of progestogens; a synthetic progestogen that has progestational effects similar to progesterone.
- synthetic progestins have higher activity and are administered at significantly lower dosages relative to natural progesterone.
- Prevailing transdermal patch technologies utilize progestins over progesterone. This is due to, among others, the difficulty with solubilizing natural progesterone which is relatively insoluble, particularly at high dosages. Solubilized drug substances are preferred in the manufacture of the various patch technologies, particularly matrix and reservoir technologies. Synthetic progestins typically have greater potency and therefore lower dosage requirements. The reduced amount of progestin drug substance relative to a given volume of drug product generally affords relatively easier formulation solubility. For example, a drug load of 2.7 mg of northethindrone acetate is provided within a 9 square cm round CombiPatch® product; a drug load of 4.8 mg of norethindrone acetate within the 16 square cm patch product.
- Progesterone is defined by a lower potency and therefore a higher dosage requirement. A much larger amount of progesterone drug substance is required, up to 200 mg, in a patch product. Given the higher dosage requirements and relative insolubility of progesterone, no transdermal patch employing a natural progesterone drug substance has been successfully commercialized.
- the present disclosure provides, among other aspects, solubilized progesterone that can be used with transdermal patch technologies, and transdermal patches comprising progesterone, alone or in combination with at least one estrogen drug substance including, without limitation, estradiol, and other drug substances having estradiol or estradiol-like biological activity that are well known in the art.
- Timing for HRT dosage administration is often varied cyclically, with estrogens taken daily and progesterone taken for approximately two weeks of every month; a method often referred to as “cyclic-sequential” or “sequentially-combined” HRT.
- This method is intended to mimic the natural menstrual cycle and typically causes menstruation similar to a period after the progesterone is stopped. This regime is most typically used in peri-menopausal or newly menopausal women as the alternative continuous method often resulting in irregular bleeding.
- An alternate method involving a constant dosage with both estrogen and progesterone delivered daily is called “continuous-combined” HRT. This method usually results in no menstruation and is used most often after a woman has been menopausal for some time.
- each of an estrogen and progesterone may be administered in the same or different dosage forms.
- the present disclosure includes each of an estrogen and progesterone in a transdermal patch.
- the present disclosure provides for progesterone administered in a transdermal patch.
- cyclic-HRT with combination estrogen and progesterone
- doctors desiring to prescribe cyclic-HRT are required to prescribe two separate products, namely, an estrogen patch and a combination estrogen/progesterone patch or an estrogen patch along with another form of progesterone including oral or topical.
- Such separate dosing regimes often result in poor patient compliance due to, among others, confusion as to how and when to take each of the medications throughout the prescribed therapy period. Increased patient morbidity may result.
- hormone replacement therapies comprising solubilized progesterone alone and optionally with an estrogen, cyclic/sequential and continuous-combined dosing regimes, and administered via transdermal HRT delivery systems.
- solubilized progesterone is delivered alone via a transdermal patch
- one or more estrogen compounds may be delivered concurrently on the same transdermal patch, or via any other known method of delivery.
- a 28-day or monthly regime of transdermal patches can be packaged in a single package having delivery days identified to improve and optimize compliance.
- Various examples of such HRT transdermal delivery systems and uses thereof, each in accordance with the present invention, are set forth below.
- FIG. 1 illustrates a cross-sectional view of an embodiment of a transdermal patch in accordance with the present disclosure
- FIG. 2 illustrates a cross-sectional view of another embodiment of a transdermal patch in accordance with the present disclosure
- FIG. 3 illustrates a cross-sectional view of an embodiment of a transdermal reservoir in accordance with the present disclosure
- FIGS. 4 , 5 , 6 , and 7 each illustrates a different sequence control device for a cyclic/sequential hormone replacement therapy regime in accordance with the present disclosure.
- excipients refers to non-active pharmaceutical ingredients such as carriers, solvents, oils, lubricants and others used in formulating pharmaceutical products. They are generally safe for administering to mammals, including humans, according to established governmental standards, including those promulgated by the United States Food and Drug Administration.
- medium chain means any medium chain carbon-containing substance, including C4-C18, and including C6-C12 substances, fatty acid esters of glycerol, fatty acids, and mono-, di-, and tri-glycerides of such substances.
- micronized progesterone includes micronized progesterone having an X50 particle size value below about 15 microns and/or having an X90 particle size value below about 25 microns.
- micronized estradiol includes micronized estradiol having an X90 particle size value below about 7 microns.
- natural means bio-identical hormones prepared to match the chemical structure and effect of those that occur naturally in mammalian bodies, including humans (i.e., endogenous).
- An exemplary natural estrogen is estradiol (also described as 17 ⁇ -estradiol and E2) and a natural progestogen is progesterone.
- oils may be any pharmaceutically acceptable substance, such as an organic oil other than peanut oil, that would suspend and/or solubilize any suitable progesterone, starting material, or precursor, including micronized progesterone as described herein. More specifically, oils may include, for example and without limitation, medium chain fatty acids, generally of the group known as medium chain fatty acids consisting of at least one mono-, di-, and triglyceride, or derivatives thereof, or combinations thereof.
- pharmaceutically acceptable indicates that the designated carrier, vehicle, diluent, excipient(s), and/or salts and other derivatives is generally chemically and/or physically compatible with the other ingredients comprising the formulation, and physiologically compatible with the recipient thereof.
- pharmaceutically acceptable excipients such as solvents, co-solvents, surfactants, emulsifiers, oils and carriers.
- transdermal patch refers to any adhesive construct suitable to adhere to the skin of a mammal, and to deliver, among one or more drug substances, physiologically effective amounts of solubilized progesterone through the skin of a mammal, including, for example and without limitation, a human.
- the construct may be in the form of a flexible strip, comprising the desired amount of solubilized progesterone and one or more optional additional drug substances including estrogen.
- treatment contemplates partial or complete inhibition of the disease state when a formulation as described herein is administered prophylactically or following the onset of the disease state for which such formulation is administered.
- prophylaxis refers to administration of the drug substance(s) to a mammal, including human, to protect the mammal from any of the disorders set forth herein, as well as others.
- drug load means the amount of drug substance in a given formulation as described herein.
- ily dose means the nominal transdermal delivery rate (mg per day) of a drug substance; for example delivery of a drug substance via skin of average permeability.
- X50 means that one-half of the particles in a sample are smaller in diameter than a given number.
- micronized progesterone having an X50 of 15 microns means that, for a given sample of micronized progesterone, one-half of the particles have a diameter of less than 15 microns.
- X90 means that ninety percent (90%) of the particles in a sample are smaller in diameter than a given number.
- “Fully solubilized progesterone” as used herein means progesterone which is about 100% in solution, i.e., at least 98% in solution.
- Partially solubilized progesterone as used herein means progesterone which is in any state of solubilization up to but not including about 100%, i.e., up to but not including 98% in solution.
- estradiol includes estradiol in anhydrous and hemihydrate forms.
- transdermal pharmaceutical formulations comprising solubilized progesterone and transdermal pharmaceutical formulations comprising solubilized progesterone and at least one estrogen compound.
- the transdermal patches are prepared by methods well known in the art, limited only by the drug load capacity of the respective technology.
- one common transdermal technology comprises a polymer matrix (or matrices) design wherein the polymer matrix can be prepared using natural polymers including, for example and without limitation, cellulose derivatives, zein, gelatin, shellac, waxes, proteins, gums and their derivatives, natural rubber, starch and the like; synthetic elastomers including, for example and without limitation, polybutadiene, polyisobutylene, hydrin rubber, polysiloxane and other silicone pressure sensitive adhesives available from Dow Corning (Elizabethtown, Ky.), silicone rubber, nitrile-containing compounds, acrylonitrile, butyl rubber, styrenebutadieine rubber, neoprene and the like; and/or synthetic homopolymers or copolymers including, for example and without limitation, polyvinyl alcohol, polyvinyl chloride, polyethylene, polypropylene, polyacrylate, polystyrene, polyamide, polyurea, polyvinylpyrrolidon
- an adhesive is used to affix the transdermal patch.
- adhesives can be affixed as a layer to the drug substance-containing matrix, or as one of the ingredients used to prepare the matrix.
- Other matrix technologies can include crystallization inhibitors and other pharmaceutically acceptable excipients.
- Matrix technology can also be developed into single or multi-layer patches. See, for example, U.S. Pat. Nos. 5,474,783, 5,958,446, and 6,440,454, and PCT Application Publication No. WO 97/43989, each of which are incorporated herein by reference.
- a reservoir system typically characterized by the inclusion of a reservoir: a compartment containing solubilized or suspended drug substance or substances, which is separate and distinct from the release liner.
- Various adhesive systems are also available for reservoir-type systems. Reservoir systems are frequently the system of choice when substantial drug loads are required. See, for example, U.S. Pat. Nos. 7,387,789, 5,656,286, 8,114,434, 6,024,976, and U.S. Patent Publication Nos.: 2012/0269878, and 2012/0283671, each of which are incorporated herein by reference.
- transdermal patch technologies include, for example and without limitation, iontophoresis, electroporation, ultrasound/sonophoresis, and microscopic projection (e.g., microneedles) (see, e.g., Patel, D., et al., The Pharma Innovation, Transdermal Drug Delivery System: A Review, Vol. 1, No. 4, pg. 66-75 (2012)).
- transdermal systems as described herein can be used for the preparation of solubilized progesterone transdermal patches, with or without the addition of at least one estrogen drug substance or other compatible drug substance(s).
- a therapeutically effective amount of solubilized progesterone is at least one drug substance in said formulation for the treatment of a mammal, including humans: for endometrial hyperplasia; for secondary amenorrhea; as a method of treatment for preterm birth when said mammal has a shortened cervix; and other disease states or conditions treated with supplemental progesterone (collectively, “progesterone-deficient states”); and wherein an estrogen drug substance is optionally included in said formulations.
- Additional aspects of the present disclosure include the use of formulations as described herein, wherein a therapeutically effective amount of solubilized progesterone and at least one solubilized estrogen drug substance, typically estradiol, are included in said formulations for the treatment of a mammal, including humans, having those disease states treated by the administration of progesterone and, menopause-related symptoms including, for example, vasomotor symptoms; in relation to treatment of hypoestrogenism related symptoms including, for example and without limitation, hot flashes and night sweats (vasomotor symptoms), sleep disturbances, mood changes and vulvo-vaginal atrophy; and osteoporosis and other non-menopausal disease states or conditions treated with supplemental estrogen (collectively, “estrogen-deficient states”).
- the transdermal patches described herein that contain both progesterone and an estrogen drug substance can be used for the treatment of one or more progesterone-deficient states and one or more estrogen-deficient states.
- the solubility proportion i.e., the proportion of a solute that enters solution
- the weight ratio of estradiol to the weight of the entire solution is also notable due to the intended dose amounts, discussed herein.
- each drug substance is administered to a mammal, including humans, in need of treatment.
- An exemplary cyclic/sequential regime comprises daily delivery of from about 0.01 mg to about 2.0 mg of estradiol for 14-18 days, followed by daily delivery of from about 0.01 mg to about 2.0 mg of estradiol per day, and about 10 mg to about 200 mg of progesterone for 10-14 days. Cyclic/sequential regimes may be especially useful for menopausal females.
- exemplary delivery dosages include one or more estrogen drug substances, typically estradiol (i.e., 17 ⁇ -estradiol), for use in the formulations described herein include, without limitation, 0.01 mg, 0.025 mg, 0.05 mg, 0.0625 mg, 0.1 mg 0.125 mg, 0.25 mg, 0.375 mg, 0.50 mg, 0.625 mg, 0.75 mg, 1.0 mg, 1.125 mg, 1.25 mg, 1.375 mg, 1.50 mg, 1.625 mg, 1.75 mg and 2.0 mg per day.
- estradiol typically 17 ⁇ -estradiol
- the daily delivery dosage estradiol is from about 0.01 mg to about 0.1 mg, from about 0.05 mg to about 0.5 mg, from about 0.1 mg to about 1.0 mg, from about 0.625 mg to about 2.0 mg, from about 0.5 mg to about 2.0 mg, from about 0.01 mg per day, and from about 0.05 mg per day.
- exemplary delivery dosages of progesterone for use in the formulations described herein include, without limitation, 10 mg, 12.5 mg, 20 mg, 25 mg, 30 mg, 50 mg, 75 mg, 100 mg, 125 mg, 150 mg, 175 mg and 200 mg per day.
- the daily delivery dosage of progesterone is from about 10 mg to about 100 mg, from about 20 mg to about 80 mg, from about 20 mg to about 30 mg, from about 20 mg to about 50 mg, from about 25 mg to about 75 mg, from about 100 mg to about 150 mg, from about 100 mg to about 125 mg, from about 125 mg to 150 mg, from about 10 mg, from about 20 mg, and from about 30 mg per day.
- estradiol and progesterone can be administered in formulations described herein either alone or in combination. These dosage strengths, as used herein in transdermal delivery systems, are limited only by the drug load capacity of the respective technology. Estrogen drug substances other than estradiol may also be used in the present transdermal formulation, at the indicated label dose or as otherwise prescribed by physicians.
- drug loads for the present transdermal pharmaceutical formulations can contain any amount necessary for partial-daily, daily, or multi-daily patches to provide the daily required doses, including the exemplary doses set forth herein.
- Drug loads for patches of the present disclosure for solubilized progesterone include, for example and without limitation, about 10 mg, 12.5 mg, 20 mg, 25 mg, 30 mg, 50 mg, 75 mg, 100 mg, 125 mg, 150 mg, 175 mg and 200 mg, 250 mg, 300 mg, 350 mg, 400 mg, 450 mg, 500 mg, 550 mg, 600 mg, 650 mg, and 700 mg per patch.
- the drug load of progesterone is not less than about 10 mg, 20 mg, 30 mg, 100 mg, 200 mg, 300 mg, 200 mg, 400 mg, and 600 mg per day.
- the drug load for one or more estrogen drug substances include, for example and without limitation, about 0.01 mg, 0.025 mg, 0.05 mg, 0.0625 mg, 0.1 mg 0.125 mg, 0.25 mg, 0.375 mg, 0.50 mg, 0.625 mg, 0.75 mg, 1.0 mg, 1.125 mg, 1.25 mg, 1.375 mg, 1.50 mg, 1.625 mg, 1.75 mg and 2.0 mg.
- the drug load for one or more estrogen drug substance is from about 0.01 mg to about 0.1 mg, from about 0.05 mg to about 0.5 mg, from about 0.1 mg to about 1.0 mg, from about 0.625 mg to about 2.0 mg, from about 0.5 mg to about 2.0 mg, from about 0.5 mg to 0.6 mg, from about 0.01 mg, and from about 0.05 mg per day.
- Progesterone formulations of the present disclosure are prepared by solubilizing progesterone drug substance via blending with a pharmaceutically acceptable oil; generally, the oil comprises at least one medium chain fatty acid such as medium chain fatty acids consisting of at least one mono-, di-, or triglyceride, or derivatives thereof, or combinations thereof. Sufficient oil is used to form a solubilized progesterone.
- additional excipients including, for example and without limitation, anti-oxidants, permeability enhancers, crystallization inhibitors and the like.
- a patch in accordance with the present disclosure is administered every three to four days in postmenopausal women, and may produce the following target absorption profile for estradiol and progesterone.
- a target steady-state serum concentration of about 30 to 60 pg/mL may be achieved.
- a target average steady-state serum concentration of about 45 to 50 pg/mL may be achieved, which is equivalent to the normal ranges observed at the early follicular phase in premenopausal women.
- concentrations may be achieved within 12 to 24 hours following patch delivery.
- the patch may be configured so that minimal fluctuation in serum estradiol concentrations is achieved following patch application, which indicates a consistent hormone delivery over the application interval.
- a target average steady-state serum concentration may be achieved within 12 to 24 hours following patch delivery system.
- progesterone is fully solubilized using, for example and without limitation, sufficient amounts of: Transcutol and Miglyol; Transcutol, Miglyol and Capmul PG 8 and/or PG 10; Campul MCM; Capmul MCM and a non-ionic surfactant; and Campul MCM and Gelucire.
- oils can be used for full solubilization of progesterone.
- Capmul MCM and a non-ionic surfactant can be used at ratios including, for example and without limitation: 65:35, 70:30, 75:25, 80:20, 85:15 and 90:10.
- Campul MCM and Gelucire can be used at ratios including, for example and without limitation, 6:4, 7:3, 8:2, and 9:1.
- these oils and/or solubilizers, as defined herein, and combinations thereof can be used to form combination estradiol and progesterone formulations of the present disclosure.
- formulations do not include peanut oil. The lack of peanut oil obviates the risk posed to those having peanut-based allergies.
- Pharmaceutically acceptable oils include, without limitation, the use of at least one of caproic fatty acid; caprylic fatty acid; capric fatty acid; tauric acid; myristic acid; linoleic acid; succinic acid; glycerin; mono-, di-, or triglycerides and combinations and derivatives thereof; a polyethylene glycol; a polyethylene glycol glyceride (Gelucire®; GATTEFOSSE SAS, Saint-Priest, France); a propylene glycol; a caprylic/capric triglyceride (Miglyol®; SASOL Germany GMBH, Hamburg; Miglyol includes Miglyol 810, 812, 816 and 829); a caproic/caprylic/capric/lauric triglyceride; a caprylic/capric/linoleic triglyceride; a caprylic/capric/succinic triglyceride; propylene glyco
- progesterone is fully solubilized using, for example and without limitation, sufficient amounts of: Transcutol and Miglyol; Transcutol, Miglyol and Capmul PG 8 and/or PG 10; Capmul MCM; Capmul MCM and a non-ionic surfactant; and Capmul MCM and Gelucire.
- Capmul MCM and a non-ionic surfactant can be used at ratios of about 99:1 to 2:1, including, for example and without limitation: 60:40, 65:35, 70:30, 75:25, 80:10, 80:15, 85:20, 90:10, and 98:1.
- the ratios of oil (e.g., medium chain fatty acid esters of monoglycerides and diglycerides) to non-ionic surfactant can be significantly higher.
- Capmul MCM and Gelucire were used in ratios of up to about 65:1, e.g., 8:1, 22:1, 49:1, 65:1 and 66:1. See, e.g., Tables 13-17, below.
- useful ratios can be 8:1 or greater, e.g., 60 to 70:1.
- these oils and/or solubilizers, as defined herein, and combinations thereof, can be used to form combination estradiol and progesterone formulations of the present disclosure.
- oils used to solubilize estradiol and to suspend, partially solubilize, or fully solubilize progesterone include medium chain fatty acid esters, (e.g., esters of glycerol, polyethylene glycol, or propylene glycol) and mixtures thereof.
- the medium chain fatty acids are C6 to C14 or C6 to C12 fatty acids.
- estradiol or progesterone (or both) is soluble in the oils at room temperature, although it may be desirable to warm the oils up until they are in a liquid state.
- the oil or oil/surfactant is liquid at between room temperature and about 50C, e.g., at or below 50C, at or below 40C, or at or below 50 C.
- Gelucire 44/14 is heated to about 65 C and Capmul MCM is heated to about 4° C. to facilitate mixing of the oil and non-surfactant, although such heating is not necessary to dissolve the estradiol or progesterone.
- the solubility of estradiol in the oil (or oil/surfactant) is at least about 0.5 wt %, e.g., 0.8 wt % or higher, or 1.0 wt % or higher.
- Illustrative examples of mono- and diglycerides of medium chain fatty acids include, among others, Capmul MCM, Capmul MCM C10, Capmul MCM C8, and Capmul MCM C8 EP. These oils are C8 and C10 fatty acid mono- and diglycerides. Illustrative examples of oils that are triglycerides of medium chain fatty acids include, among others, Miglyol 810 and Miglyol 812.
- oils that are medium chain fatty acid esters of propylene glycol include, among others, Capmul PG-8, Capmul PG-2L EP/NF, Capmul PG-8 NF, Capmul PG-12 EP/NF and Capryol.
- Other illustrative examples include Miglyol 840.
- oils that are medium chain fatty acid esters of polyethylene glycol include, among others, Gelucire 44/14 (PEG-32 glyceryl laurate EP), which is polyethylene glycol glycerides composed of mono-, di- and triglycerides and mono- and diesters of polyethylene glycol. Without intending to be bound to any particular mechanism, it appears that at least in formulations comprising small amounts of Gelucire, e.g., 10 wt % or less, the primary function of this oil is as a non-ionic surfactant.
- Gelucire 44/14 PEG-32 glyceryl laurate EP
- fatty acids comprise predominantly medium chain length, saturated, fatty acids, specifically predominantly C8 to C12 saturated fatty acids.
- a product information sheet for Myglyol by SASOL provides as the composition of fatty acids as follows:
- Tests 810 812 818 829 840 Caproic acid (C6:0) max. 2.0 max. 2.0 max. 2 max. 2 max. 2 Caprylic acid (C8:0) 65.0-80.0 50.0-65.0 45-65 45-55 65-80 Capric acid (C10:0) 20.0-35.0 30.0-45.0 30-45 30-40 20-35 Lauric acid (C12:0) max. 2 max. 2 max. 3 max. 3 max. 2 Myristic acid (C14:0) max. 1.0 max. 1.0 max. 1 max. 1 max. 1 Linoleic acid (C18:2) — — 2-5 — — Succinic acid — — — 15-20 —
- oils are often mixtures. So, for example, when an oil is described herein as a saturated C8 fatty acid mono- or diester of glycerol, it will be understood that the predominant component of the oil, i.e., >50 wt % (e.g., >75 wt %, >85 wt % or >90 wt %) are caprylic monoglycerides and caprylic diglycerides.
- medium chain fatty acid glycerides e.g., C6-C12, C8-C12, or C8-C10 fatty acid mono- and diglycerides or mono-, di-, and triglycerides are very well suited for dissolving estradiol; good results have been obtained with an oil that is predominantly a mixture of C8-C10 saturated fatty acid mono- and diglycerides. Longer chain glycerides appear to be not as well suited for dissolution of estradiol. On the other hand, high solubility of progesterone has been obtained in mixtures that are predominantly medium chain fatty acid triglycerides.
- estradiol has been obtained in 2-(2-Ethoxyethoxy)ethanol, e.g., Transcutol and in Propylene glycol monocaprylate, e.g., CapryolTM 90 (Gattefosse).
- the selected oil does not require excessive heating in order to solubilize progesterone or estradiol.
- the formulation comprises medium chain fatty acid mono- and diglycerides (e.g., Capmul MCM) and polyethylene glycol glycerides (e.g., Gelucire) as a surfactant
- the oil and/or the surfactant can be warmed up, e.g., to about 65 C in the case of the surfactant and less in the case of the oil, to facilitate mixing of the oil and surfactant.
- the estradiol can be added at this temperature or at lower temperatures as the mixture cools or even after it has cooled as temperatures above room temperature, e.g., about 2° C., are not required to solubilize the estradiol in preferred oils.
- the progesterone can also be added as the mixture cools, e.g., to below about 4° C. or to below about 3° C., even down to room temperature.
- estradiol is solubilized.
- Solubilized estradiol may include estradiol that is approximately: 90% soluble in a solvent; 93% soluble in a solvent; 95% soluble in a solvent; 97% soluble in a solvent; 99% soluble in a solvent; and 100% soluble in a solvent.
- Solubility may be expressed as a mass fraction (% w/w, also referred to as wt %).
- solubilizers include, for example and without limitation, glyceryl mono- and di-caprylates, propylene glycol and 1,2,3-propanetriol (glycerol, glycerin, glycerine).
- Progesterone and estrogen in particular estradiol, may be micronized to facilitate solubilization.
- Progesterone and estrogen may be micronized by any one of the multiple methods typically utilized by one skilled in the art.
- micronized progesterone has an X50 particle size value of less than about 15 microns, less than about 10 microns, less than about 5 microns and/or less than about 3 microns.
- micronized progesterone has an X90 particle size value of less than about 25 microns, less than about 20 microns, and/or less than about 15 microns.
- micronized estradiol has an X90 particle size value of less than about 10 microns, less than about 8 microns, and/or less than about 7 microns.
- Particle size may be determined in any suitable manner.
- a Beckman Coulter LS 13 320 Laser Diffraction Particle Size Analyzer (the “Beckman Device”) may be used to determine particle size.
- particle size may be represented by various metrics, for example, through an X50 particle size, and/or X90 particle size, or any similar descriptions of particle size.
- At least one estrogen drug substance is solubilized and then combined with solubilized progesterone, or may be co-solubilized with progesterone as taught herein.
- the solubilizing agent for an estrogen drug substance is selected from at least one of a solvent or co-solvent.
- Suitable solvents and co-solvents include any mono-, di- or triglyceride and glycols, and combinations thereof. More specifically, other solubilizers include, for example and without limitation, glyceryl mono- and di-caprylates, propylene glycol and 1,2,3-propanetriol (glycerol, glycerin, glycerine).
- Anionic and/or non-ionic surfactants can be used in other embodiments of the presently disclosed formulations containing solubilized progesterone or a combination of such progesterone and at least one solubilized estrogen drug substance.
- a non-ionic surfactant is used.
- Exemplary non-ionic surfactants may include, for example and without limitation, one or more of oleic acid, linoleic acid, palmitic acid, and stearic acid esters or alcohols.
- the non-ionic surfactant may comprise polyethylene sorbitol esters, including polysorbate 80, which is commercially available under the trademark TWEEN 80® (Sigma Aldrich, St. Louis, Mo.).
- Polysorbate 80 comprises approximately 60%-70% oleic acid with the remainder comprising primarily linoleic acids, palmitic acids, and stearic acids. Polysorbate 80 may be used in amounts ranging from about 5 to 50%, and in certain embodiments, about 30% of the formulation total mass.
- the non-ionic surfactant is selected from one or more of glycerol and polyethylene glycol esters of fatty acids, for example, lauroyl macrogol-32 glycerides and/or lauroyl polyoxyl-32 glycerides, commercially available as Gelucire, including, for example, Gelucire 44/11 and 44/14. These surfactants may be used at concentrations greater than about 0.01%, and, in some embodiments in amounts of about 0.01%-10.0%, 10.1%-20%, and 20.1%-30% may be used. In certain examples, below, Gelucire 44/14 is used as a surfactant in amounts of 1 to 10 wt %. See, e.g., Tables 13-17, below.
- Other non-ionic surfactants include, e.g., Labrasol® PEG-8 Caprylic/Capric Glycerides (Gattefosse) and Labarafil® corn/apricot oil PEG-6 esters (Gattefosse).
- non-ionic surfactants include PEG-6 palmitostearate and ethylene glycol palmitostearate, which is available commercially as TEFOSE 63® (“Tefose 63”) (GATTEFOSSE SAS, Saint-Priest, France) which can be used with, for example, Capmul MCM having ratios of MCM to Tefose 63 of, for example, 8:2 and 9:1.
- TEFOSE 63® GATTEFOSSE SAS, Saint-Priest, France
- solubilizing agents with non-ionic surfactants include, for example, Miglyol:Gelucire 50/13 and Miglyol:Tefose 63.
- Anionic surfactants are well known and can include, for example and without limitation: ammonium lauryl sulfate, dioctyl sodium sulfosuccinate, perfluoro-octane sulfonic acid, potassium lauryl sulfate and sodium stearate.
- non-ionic and/or anionic surfactants can be used alone or with at least one solubilizing agent or can be used in combination with other surfactants. Accordingly, such surfactants, or any other excipient as set forth herein, should be used to provide a solubilized progesterone drug substance; to provide a solubilized estrogen drug substance; or optionally a solubilized progesterone drug substance with at least one estrogen drug substance; upon release from a transdermal patch of the present disclosure, with consistency of dissolution and/or delivery of the solubilized progesterone drug substance and solubilized estrogen drug substance, or optionally a solubilized progesterone drug substance with estrogen drug substance, that promotes transdermal absorption.
- an antioxidant is used. Any suitable anti-oxidant may be used such as, for example and without limitation butylated hydroxytoluene.
- Permeability enhancers are chemical substances that increase the flux of a drug substance through the skin. These substances may include, for example, various glycols such as dipropylene or propylene glycol, oils such as olive oil, squalene or lanolin, long chain ethers and esters, urea and various urea derivatives, solvents such as dimethylsulfoxide (DMSO) and dimethylformamide (DMF), salicylic acid, various amino acids, Vitamin-C, Vitamin-A, and Vitamin-E, and the like.
- various glycols such as dipropylene or propylene glycol
- oils such as olive oil, squalene or lanolin, long chain ethers and esters, urea and various urea derivatives
- solvents such as dimethylsulfoxide (DMSO) and dimethylformamide (DMF)
- salicylic acid various amino acids
- Vitamin-C Vitamin-C
- Vitamin-A Vitamin-A
- Vitamin-E Vitamin-E
- solubilizers As is with all oils, solubilizers, excipients, antioxidants, permeability enhancers, crystallization inhibitors and any other additives used in intermediate formulations (e.g., during production during solublization) and during production of the resulting transdermal drug products described herein, each is to pharmaceutically acceptable.
- the embodiments herein provide for the preparation and use of a solubilized progesterone transdermal patch.
- a solubilized progesterone transdermal patch can be used by itself or as concomitant administration with an estrogen drug substance which can be administered via various dosage forms and via various routes of administration.
- Such patches can also co-administer solubilized progesterone and at least one solubilized estrogen drug substance.
- Transdermal patches according to the present disclosure will vary by patch surface area, as dependent upon the dosage concentration required over the desired time for release, the actual release mechanism, and shape.
- Transdermal patch surface area can range, for example and without limitation, from less than about 10 cm2 to greater than about 100 cm2.
- a transdermal patch may be from about 2.0, 2.5 cm2, 3.0 cm2, 3.5 cm2, 4.0 cm2, 4.5 cm2, 5.0 cm2, 5.5 cm2, 6.0 cm2, 6.5 cm2, 7.0 cm2, 7.5 cm2, 8.0 cm2, 8.5 cm2, 9.0 cm2, 9.5 cm2, or about 10 cm2.
- a patch may be from about 9 cm2 to about 16 cm2 in surface area.
- transdermal patches of the present disclosure can include any conventional form such as, for example, adhesive matrix, polymeric matrix, reservoir patch, matrix or monolithic-type laminated structure, or other release-rate modifying mechanisms known in the art, and are generally comprised of one or more backing layers, adhesives, permeation enhancers, an optional rate controlling membrane and a release liner which is removed to expose the adhesives prior to application.
- Polymeric matrix patches also comprise a polymeric-matrix forming material.
- Various delivery systems can be used to administer the formulations of the present disclosure, including, for example, encapsulation in liposomes, microbubbles, emulsions, microparticles, microcapsules, nanoparticles, microneedles and the like.
- a 28-day or monthly regime of transdermal patches can be packaged in a single kit having administration days identified to improve compliance and reduce associated symptoms, among others.
- One or more of the transdermal patches may contain no estradiol, for example, and/or no progesterone.
- Transdermal patches that comprise no estrogen or progesterone drug substance may be referred to as placebos.
- Transdermally administered formulations of the present disclosure containing solubilized progesterone are used for the treatment of endometrial hyperplasia, secondary amenorrhea and other disease states treated with supplemental progesterone.
- progesterone-containing formulations described herein are used to treat the effects of the administration of supplemental estrogen whether administered alone or in combination with solubilized estradiol of the present disclosure or other estrogen-containing formulations.
- Transdermally administered formulations of the present disclosure containing solubilized estradiol are used to treat estrogen-deficient states, including vasomotor symptoms, for example, in relation to treatment of hypoestrogenism related symptoms including, for example and without limitation, hot flashes and night sweats (vasomotor symptoms), sleep disturbances, mood changes, vulvo-vaginal atrophy, and osteoporosis and other non-menopausal disease states treated with supplemental estrogen.
- vasomotor symptoms including, for example and without limitation, hot flashes and night sweats (vasomotor symptoms), sleep disturbances, mood changes, vulvo-vaginal atrophy, and osteoporosis and other non-menopausal disease states treated with supplemental estrogen.
- Various objects of the disclosure is to provide increased patient compliance secondary to ease of use in a single product kit having both progesterone and estradiol, and to reduce the metabolic and vascular side effects of the commonly used synthetic progestins in combination HRT (norethindrone acetate, medroxyprogesterone acetate, etc.) including, for example, stroke, heart attacks, blood clots and breast cancer.
- FIG. 1 illustrates the cross section of a patch 10 comprising a backing layer 13 , an adhesive matrix containing active hormone(s) 11 , and a removal release layer 12 .
- the arrows in FIG. 1 indicate the direction of migration of drug substance(s).
- FIG. 2 illustrates another embodiment of a patch comprising a release layer 4 breakable across perforation or slit 42 , and active adhesive layers 1 and 2 .
- FIG. 3 illustrates the cross-sectional view of an embodiment of a liquid reservoir-type transdermal delivery device.
- the device comprises housing 2 , a porous layer 3 , a removable sealing film 4 , and a liquid composition 1 containing the active hormone(s).
- the arrows 5 in FIG. 3 illustrate the direction of migration of the drug substance(s).
- a plurality of transdermal systems can be packaged together, whether cyclic/sequential or continuous-combined.
- the package may comprise a packaging system further configured to guide the application of the transdermal systems throughout the intended cycle; such as throughout the application days and/or weeks within an intended dosing cycle (“sequence control device”).
- sequence control devices offer improved patient compliance and reduce associated symptoms, among other advantages.
- a 28-day or monthly regime of transdermal systems can be packaged in a sequence control device having application days and/or weeks identified.
- a 28-day or monthly regime of transdermal systems can be packaged in a plurality of sequence control devices, for example, 2 or 4.
- sequence control devices may be used with transdermal systems to construct kits.
- Exemplary sequence control devices comprise a plurality of storage elements, wherein each storage element corresponds to one or more days and wherein each storage element encloses one or more transdermal systems therein for application during the corresponding days (e.g., on the first day of the corresponding days).
- a storage element may comprise a blister, a laminate, or another air-tight configuration, for enclosing one or more transdermal systems therein.
- Exemplary sequence control devices can optionally also comprise a plurality of spacer elements arranged between storage elements, wherein each spacer element corresponds to one or more days during which no new application of a transdermal system is prescribed.
- a spacer element may correspond to a placebo transdermal system or the absence of any transdermal system. Spacer elements may be especially useful for embodiments wherein one storage element corresponds to one day, and the enclosed transdermal system(s) is/are configured to be worn for more than one day.
- Exemplary sequence control devices can comprise storage elements, (and optional spacer elements) sequentially coupled to a common substrate and arranged thereon to be adjacent in rows and/or columns.
- exemplary sequence control devices can comprise storage elements (and optional spacer elements) sequentially stacked.
- the sequence of such stacked elements can be maintained in various ways, for example, each of the stacked elements being coupled at one of its edges to a common substrate, or the stacked elements being contained within a container having a dispensing edge configured to only be opened large enough to dispense a single storage or spacer element at a time.
- the stacked elements are biased toward the dispensing edge, for example, mechanically or simply under the influence of gravity if the dispensing edge is situated at the bottom of the sequence control device.
- FIG. 5 illustrates another 28-day cyclic/sequential estrogen (“E”) progesterone (“P”) regime of transdermal systems packaged in a sequence control device, wherein storage and spacer elements are sequentially arranged on a common substrate to be variously adjacent in rows and columns.
- the substrate can comprise a plurality of scores, perforations or dividers between adjacent elements.
- the transdermal systems are configured to be worn for 3-4 day duration and each storage element corresponds to one day.
- FIG. 6 illustrates another embodiment of a 28-day cyclic/sequential estrogen (“E”) progesterone (“P”) regime of transdermal systems packaged in a sequence control device, wherein storage and spacer elements are sequentially stacked, the stacked elements being contained within a container having a dispensing edge configured to only be opened at the bottom large enough to dispense a single storage or spacer element at a time.
- the stacked elements are biased toward the dispensing edge under the influence of gravity.
- the transdermal systems are configured to be worn for 3-4 day duration and each storage element corresponds to one day.
- FIG. 7 illustrates another embodiment of a 28-day cyclic/sequential estrogen (“E”) progesterone (“P”) regime of transdermal systems packaged in a sequence control device, wherein storage elements are sequentially stacked, each of the stacked elements being coupled at one of its edges to a common substrate.
- the transdermal systems are configured to be worn for a one-week duration and each storage element corresponds to one day.
- the following examples illustrate formulations of solubilized progesterone and estradiol, compositions of adhesive, liquid matrix compositions, and reservoir technologies, that incorporate solubilized progesterone and estradiol, for transdermal HRT, particularly NHRT.
- the examples illustrate target loading of adhesive compositions onto release layers of various size for the preparation of transdermal patches.
- the examples further illustrate exemplary loading of liquid compositions of solubilized progesterone, optionally including estradiol, into reservoirs usable for liquid transdermal delivery systems.
- the flux of progesterone and estradiol through the skin delivered from any of the matrices described herein can be in a variety of ranges; in one embodiment in a range of from about 0.1 to about 20 ⁇ g/cm2/hr.
- the flux depends on the type of matrix, i.e. adhesive or liquid compositions, the non-active ingredients, the inclusion of permeation enhancers, release-rate modifying mechanisms, crystallization inhibitors and the physiology of the mammal, typically human, subject.
- Exemplary formulas are prepared by heating various solubilizers and then adding micronized progesterone and optionally estradiol to the heated mixture.
- Campul MCM is heated to between 30° C. to 50° C., more preferably from 35° C. to 45° C., and more preferably to 40° C. +/ ⁇ 2° C.
- Gelucire 44/14 is added to the Campul MCM and mixed until dissolved. The addition is performed all at once or may be divided in portions over a period of time. Heat is continuously applied during the mixing of the requisite solubilizers. Heating and mixing are performed under an inert or relatively inert gas atmosphere. In this example, nitrogen gas (N2) is used.
- N2 nitrogen gas
- Mixing and/or heating is performed in any suitable vessel, such as a stainless steel vessel equipped with any suitable submerged mixer and optionally a vacuum may or may not be applied.
- Gelucire 44/14 is heated to 65 C and Capmul MCM is heated to 40 C+/ ⁇ 5 C to achieve mixing of the oil and the surfactant before heat is removed; estradiol is added while the mixture is cooling; progesterone is added when the mixture has dropped below about 4° C.; the mixture is then passed through a colloid mill, e.g., three times.
- TABLE B illustrates adhesive matrices that are prepared by mixing appropriate polymers and then slowly mixing in the solubilized progesterone formulae from TABLE A.
- Volatile solvents such as silicone fluids, low molecular weight alcohols, glycols or ethers, are added to adjust the viscosity of the adhesive composition and the tackiness of the dried adhesive.
- the resulting adhesive mixture containing the drug substances are used to produce various transdermal products.
- the preferred polymers for a pressure sensitive adhesive (PSA) matrix include polysiloxane PSAs from Dow Corning Corporation (Midland, Mich.), polyacrylate, polyisobutylene, polyvinylpyrrolidone, and polyethylene/vinyl acetate co-polymer.
- PSA pressure sensitive adhesive
- a suitable adhesive matrix is formed from a medical silicone PSA without the need for additional polymers.
- compositions of TABLE A will have estradiol previously added, so no additional estradiol is added into the adhesive matrix above.
- Suitable backing material may comprise plastic films of polyethylene/, vinyl acetate resins, ethylene/vinyl acetate copolymers, polyvinyl chloride, polyurethane, and the like, or metal foils, nonwoven fabric, cloth, and various laminated films.
- Resulting patch systems deliver progesterone alone, a combination of progesterone and estradiol, or estradiol alone.
- Matrix Theoretical drug Matrix Dimensions Matrix weight per substance(s) per patch Area Thickness (from patch (mg) (cm 2 ) (mm) TABLE B) (mg) Progesterone Estradiol 2.5 1 Matrix 1 250 8.925 0.3625 2.5 2 Matrix 3 500 35.625 4.50 5 1 Matrix 1 500 17.85 0.725 5 2 Matrix 2 1000 55.05 9.00 7 1 Matrix 2 700 38.535 6.3 10 1 Matrix 3 1000 71.25 9.00 16 1 Matrix 3 1600 114.00 14.40
- TABLE D illustrates exemplary compositions usable in liquid transdermal reservoirs.
- the exemplified compositions incorporate the solubilized progesterone and estradiol formulations of TABLE A as indicated.
- One or more saccharides are used, such as methyl cellulose, ethyl cellulose, carboxymethylcellulose, carboxymethylethylcellulose, starch, carrageenan, and pectin.
- the compositions further include gums such as xanthan or guar, low molecular weight glycols, and preservatives.
- TABLE D can be incorporated in delivery systems such as the embodiment generalized in FIG. 3 .
- a particle size analysis for micronized estradiol was conducted by using a Beckman Coulter LS 13 320 Laser Diffraction Particle Size Analyzer (the “Beckman Device”).
- the Beckman Device uses laser diffraction and polarization intensity differential scattering (PIDS) technology to determine the particle size distribution of materials with an overall sizing range of 0.04 ⁇ m to 2000 ⁇ m in a single scan with no extrapolation.
- the analysis yields that a sample has an X50 value of 2.652 microns and an X90 value of 6.031 microns.
- Approximately 0.01 g of a sample was dispersed with Coulter 1B dispersant then diluted with about 10 ml of deionized water. The sample dilution was then sonicated for 15 seconds and added to the Beckman Device to analyze for 90 seconds. The particle size distribution was determined using the Fraunhofer optical model.
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Priority Applications (29)
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AU2013277233A AU2013277233B2 (en) | 2012-06-18 | 2013-06-18 | Progesterone formulations |
PCT/US2013/046442 WO2013192248A1 (en) | 2012-06-18 | 2013-06-18 | Progesterone formulations |
EP13807121.2A EP2861234B1 (en) | 2012-06-18 | 2013-06-18 | Progesterone formulations |
AU2013277235A AU2013277235B2 (en) | 2012-06-18 | 2013-06-18 | Transdermal hormone replacement therapies |
JP2015518528A JP6342389B2 (ja) | 2012-06-18 | 2013-06-18 | 経皮的ホルモン補充療法 |
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BR112014031837-9A BR112014031837B1 (pt) | 2012-06-18 | 2013-06-18 | Formulações farmacêuticas líquidas compreendendo progesterona e usos destas |
US14/125,547 US10052386B2 (en) | 2012-06-18 | 2013-06-18 | Progesterone formulations |
CA2876947A CA2876947A1 (en) | 2012-06-18 | 2013-06-18 | Transdermal hormone replacement therapies |
BR112014031824A BR112014031824A2 (pt) | 2012-06-18 | 2013-06-18 | terapias de reposição hormonal transdérmica |
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US14/624,051 US9289382B2 (en) | 2012-06-18 | 2015-02-17 | Vaginal inserted estradiol pharmaceutical compositions and methods |
US14/671,655 US20150196640A1 (en) | 2012-06-18 | 2015-03-27 | Progesterone formulations having a desirable pk profile |
US14/671,651 US20150202211A1 (en) | 2012-06-18 | 2015-03-27 | Progesterone formulations having a desirable pk profile |
US15/257,727 US20170000803A1 (en) | 2012-06-18 | 2016-09-06 | Progesterone formulations having a desirable pk profile |
US15/454,898 US10471148B2 (en) | 2012-06-18 | 2017-03-09 | Progesterone formulations having a desirable PK profile |
US15/667,208 US20180055855A1 (en) | 2012-06-18 | 2017-08-02 | Progesterone formulations having a desirable pk profile |
US16/037,452 US10639375B2 (en) | 2012-06-18 | 2018-07-17 | Progesterone formulations |
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US16/578,148 US11033626B2 (en) | 2012-06-18 | 2019-09-20 | Progesterone formulations having a desirable pk profile |
US17/348,140 US11865179B2 (en) | 2012-06-18 | 2021-06-15 | Progesterone formulations having a desirable PK profile |
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PCT/US2013/046442 Continuation WO2013192248A1 (en) | 2012-06-18 | 2013-06-18 | Progesterone formulations |
US14/125,547 Continuation US10052386B2 (en) | 2012-06-18 | 2013-06-18 | Progesterone formulations |
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BR112014031824A2 (pt) | 2017-06-27 |
BR112014031837A2 (pt) | 2017-06-27 |
EP2861234B1 (en) | 2019-03-27 |
JP2015520235A (ja) | 2015-07-16 |
MX2014015900A (es) | 2015-07-17 |
AU2018222947B2 (en) | 2020-06-18 |
WO2013192248A1 (en) | 2013-12-27 |
US10052386B2 (en) | 2018-08-21 |
ZA201500212B (en) | 2017-04-26 |
JP6298460B2 (ja) | 2018-03-20 |
US20150148323A1 (en) | 2015-05-28 |
MX2014015897A (es) | 2015-03-03 |
JP6342389B2 (ja) | 2018-06-13 |
AU2018222947A1 (en) | 2018-09-20 |
US10639375B2 (en) | 2020-05-05 |
US20190008968A1 (en) | 2019-01-10 |
AU2013277235B2 (en) | 2018-04-19 |
JP2015520236A (ja) | 2015-07-16 |
CA2876964A1 (en) | 2013-12-27 |
WO2013192250A1 (en) | 2013-12-27 |
EP2861233A1 (en) | 2015-04-22 |
AU2013277233A1 (en) | 2015-01-22 |
EP2861233B1 (en) | 2019-11-06 |
EP3560500B1 (en) | 2021-12-22 |
CA2876947A1 (en) | 2013-12-27 |
EP2861234A1 (en) | 2015-04-22 |
AU2013277233B2 (en) | 2018-05-31 |
EP2861233A4 (en) | 2015-10-07 |
EP2861234A4 (en) | 2015-10-28 |
BR112014031837B1 (pt) | 2020-09-15 |
AU2013277235A1 (en) | 2015-01-22 |
EP3560500A1 (en) | 2019-10-30 |
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