FR2837100B1 - Comprimes a bases de microcapsules a liberation modifiee - Google Patents

Comprimes a bases de microcapsules a liberation modifiee

Info

Publication number
FR2837100B1
FR2837100B1 FR0203336A FR0203336A FR2837100B1 FR 2837100 B1 FR2837100 B1 FR 2837100B1 FR 0203336 A FR0203336 A FR 0203336A FR 0203336 A FR0203336 A FR 0203336A FR 2837100 B1 FR2837100 B1 FR 2837100B1
Authority
FR
France
Prior art keywords
modified release
release microcapsule
based tablets
tablets
microcapsule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0203336A
Other languages
English (en)
Other versions
FR2837100A1 (fr
Inventor
Rafael Jorda
Pierre Autant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Flamel Technologies SA
Original Assignee
Flamel Technologies SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0203336A priority Critical patent/FR2837100B1/fr
Application filed by Flamel Technologies SA filed Critical Flamel Technologies SA
Priority to BR0308487-6A priority patent/BR0308487A/pt
Priority to AU2003242818A priority patent/AU2003242818B2/en
Priority to IL16381303A priority patent/IL163813A0/xx
Priority to CA2479057A priority patent/CA2479057C/fr
Priority to US10/507,886 priority patent/US8507003B2/en
Priority to KR10-2004-7014579A priority patent/KR20040105773A/ko
Priority to CNA038063026A priority patent/CN1642530A/zh
Priority to PCT/FR2003/000827 priority patent/WO2003077888A2/fr
Priority to MXPA04009010A priority patent/MXPA04009010A/es
Priority to EP03744400A priority patent/EP1485071A2/fr
Priority to JP2003575941A priority patent/JP2005527522A/ja
Publication of FR2837100A1 publication Critical patent/FR2837100A1/fr
Application granted granted Critical
Publication of FR2837100B1 publication Critical patent/FR2837100B1/fr
Priority to IL163813A priority patent/IL163813A/en
Priority to ZA200408412A priority patent/ZA200408412B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR0203336A 2002-03-18 2002-03-18 Comprimes a bases de microcapsules a liberation modifiee Expired - Fee Related FR2837100B1 (fr)

Priority Applications (14)

Application Number Priority Date Filing Date Title
FR0203336A FR2837100B1 (fr) 2002-03-18 2002-03-18 Comprimes a bases de microcapsules a liberation modifiee
EP03744400A EP1485071A2 (fr) 2002-03-18 2003-03-14 Comprimes a base de microcapsules a liberation modifiee
IL16381303A IL163813A0 (en) 2002-03-18 2003-03-14 Modified-release tased on microcapsules
CA2479057A CA2479057C (fr) 2002-03-18 2003-03-14 Comprimes a base de microcapsules a liberation modifiee
US10/507,886 US8507003B2 (en) 2002-03-18 2003-03-14 Compressed tablets comprising microcapsules with modified release
KR10-2004-7014579A KR20040105773A (ko) 2002-03-18 2003-03-14 마이크로캡슐을 포함하는 변형 방출형 압축 정제
CNA038063026A CN1642530A (zh) 2002-03-18 2003-03-14 基于微囊的改变释放的片剂
PCT/FR2003/000827 WO2003077888A2 (fr) 2002-03-18 2003-03-14 Comprimes a base de microcapsules a liberation modifiee
BR0308487-6A BR0308487A (pt) 2002-03-18 2003-03-14 Comprimidos à base de microcápsulas de liberação modificada
AU2003242818A AU2003242818B2 (en) 2002-03-18 2003-03-14 Compressed tablets comprising microcapsules with modified release
JP2003575941A JP2005527522A (ja) 2002-03-18 2003-03-14 マイクロカプセルをベースとした徐放性錠剤
MXPA04009010A MXPA04009010A (es) 2002-03-18 2003-03-14 Tabletas comprimidas a base de microcapsulas con liberacion modificada.
IL163813A IL163813A (en) 2002-03-18 2004-08-30 Modified-release tablets based on microcapsules
ZA200408412A ZA200408412B (en) 2002-03-18 2004-10-18 Compressed tablets comprising microcapsules with modified release

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0203336A FR2837100B1 (fr) 2002-03-18 2002-03-18 Comprimes a bases de microcapsules a liberation modifiee

Publications (2)

Publication Number Publication Date
FR2837100A1 FR2837100A1 (fr) 2003-09-19
FR2837100B1 true FR2837100B1 (fr) 2004-07-23

Family

ID=27772222

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0203336A Expired - Fee Related FR2837100B1 (fr) 2002-03-18 2002-03-18 Comprimes a bases de microcapsules a liberation modifiee

Country Status (13)

Country Link
US (1) US8507003B2 (fr)
EP (1) EP1485071A2 (fr)
JP (1) JP2005527522A (fr)
KR (1) KR20040105773A (fr)
CN (1) CN1642530A (fr)
AU (1) AU2003242818B2 (fr)
BR (1) BR0308487A (fr)
CA (1) CA2479057C (fr)
FR (1) FR2837100B1 (fr)
IL (2) IL163813A0 (fr)
MX (1) MXPA04009010A (fr)
WO (1) WO2003077888A2 (fr)
ZA (1) ZA200408412B (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7906145B2 (en) 2002-04-09 2011-03-15 Flamel Technologies Oral pharmaceutical formulation in the form of aqueous suspension for modified release of active principle(s)
US7910133B2 (en) 2002-04-09 2011-03-22 Flamel Technologies Oral pharmaceutical formulation in the form of aqueous suspension of microcapsules for modified release of amoxicillin
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL130602A0 (en) 1999-06-22 2000-06-01 Dexcel Ltd Stable benzimidazole formulation
CA2359812C (fr) 2000-11-20 2004-02-10 The Procter & Gamble Company Formes posologiques pharmaceutiques a couches multiples permettant de reduire l'impact des revetement fractures
FR2842735B1 (fr) * 2002-07-26 2006-01-06 Flamel Tech Sa Microcapsules a liberation modifiee de principes actifs peu solubles pour l'administration per os
US20080181946A1 (en) * 2004-05-14 2008-07-31 Braj Bhushan Lohray Controlled Release Delivery System For Metformin
CA2593016C (fr) * 2005-01-06 2012-05-15 Cima Labs Inc. Systeme de masquage de gout pour des medicaments non plastifiants
FR2889810A1 (fr) * 2005-05-24 2007-02-23 Flamel Technologies Sa Forme medicamenteuse orale, microparticulaire, anti-mesurage
FR2881652B1 (fr) * 2005-02-08 2007-05-25 Flamel Technologies Sa Forme pharmaceutique orale microparticulaire anti-mesuage
DE602006016785D1 (de) * 2005-05-24 2010-10-21 Flamel Tech Sa Orale pharmazeutische zusammensetzung zur behandlung einer cox-2-vermittelten erkrankung
WO2006131790A2 (fr) * 2005-06-09 2006-12-14 Flamel Technologies Composition pharmaceutique de ribavirine a administration par voie orale
WO2006133733A1 (fr) * 2005-06-13 2006-12-21 Flamel Technologies Forme posologique orale comportant un systeme anti-abus
US8652529B2 (en) 2005-11-10 2014-02-18 Flamel Technologies Anti-misuse microparticulate oral pharmaceutical form
FR2892937B1 (fr) * 2005-11-10 2013-04-05 Flamel Tech Sa Forme pharmaceutique orale microparticulaire anti-mesusage
US20090036414A1 (en) * 2007-08-02 2009-02-05 Mutual Pharmaceutical Company, Inc. Mesalamine Formulations
EP2044932A1 (fr) * 2007-10-04 2009-04-08 Laboratorios del Dr. Esteve S.A. Couche de protection mécanique pour formes de dosages solides
EP2044929A1 (fr) * 2007-10-04 2009-04-08 Laboratorios del Dr. Esteve S.A. Comprimés oraux à désintégration rapide
EP2331088A4 (fr) 2008-08-06 2011-10-12 Gosforth Ct Holdings Pty Ltd Compositions et procédés de traitement de troubles psychiatriques
EP2341708B1 (fr) 2010-01-05 2017-03-08 Irdeto B.V. Variantes de diffusion de signaux numériques dans un système d'accès conditionnel
EP2544667B1 (fr) * 2010-03-09 2018-11-14 Alkermes Pharma Ireland Limited Compositions pharmaceutiques entériques résistantes aux alcools
EP2468263A1 (fr) 2010-12-23 2012-06-27 Laboratorios Del. Dr. Esteve, S.A. Formes de dosage solides compressées
GB201111712D0 (en) 2011-07-08 2011-08-24 Gosforth Ct Holdings Pty Ltd Pharmaceutical compositions
BR112014012444B1 (pt) 2011-11-23 2021-12-14 Therapeuticsmd, Inc Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
CN102641257A (zh) * 2012-03-31 2012-08-22 内蒙古医学院 阿替洛尔缓释微囊及其制备方法
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
WO2014011830A1 (fr) 2012-07-12 2014-01-16 Mallinckrodt Llc Compositions pharmaceutiques de dissuasion d'abus à libération prolongée
FI126168B (en) 2012-09-18 2016-07-29 Novaldmedical Ltd Oy A method for coating pharmaceutical substrates
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
JP2017516768A (ja) 2014-05-22 2017-06-22 セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． 天然の併用ホルモン補充療法剤及び療法
WO2016114812A1 (fr) * 2015-01-12 2016-07-21 Robert Niichel Microbilles multicouches à libération prolongée et leur procédés de fabrication
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
EP3435977A4 (fr) 2016-04-01 2019-10-16 Therapeuticsmd, Inc. Composition pharmaceutique d'hormone stéroïde
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
UY37341A (es) 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
CN108029310A (zh) * 2017-12-25 2018-05-15 翁毅 一种向土壤中缓慢施加肥料的方法
EP3740197A4 (fr) 2018-01-16 2021-11-10 Applied Materials, Inc. Compositions médicamenteuses encapsulées d'oxyde métallique et leurs procédés de préparation
CN113473980A (zh) 2019-03-01 2021-10-01 弗拉梅尔爱尔兰有限公司 在进食状态下具有改善的药代动力学的γ-羟基丁酸酯组合物
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3256153A (en) * 1963-02-08 1966-06-14 Smith Kline French Lab Method of stabilizing wax-fat coating materials and product thereof
GB1598458A (en) 1977-04-01 1981-09-23 Hoechst Uk Ltd Tableting of microcapsules
JPS5873359A (ja) 1981-10-27 1983-05-02 旭化成株式会社 医薬錠剤の製造方法
US4728512A (en) * 1985-05-06 1988-03-01 American Home Products Corporation Formulations providing three distinct releases
LU85943A1 (fr) * 1985-06-12 1987-01-13 Galephar Comprimes pharmaceutiques permettant l'administration aisee de pellets, leur preparation et leur utilisation
JPH0780754B2 (ja) 1986-08-06 1995-08-30 エーザイ株式会社 多顆粒型持続性錠剤
US5624683A (en) 1986-08-06 1997-04-29 Eisai Co., Ltd. Sustained-release multi-granule tablet
FR2606597B1 (fr) * 1986-11-17 1989-01-27 Rhone Poulenc Sante Nouvelle composition pour l'alimentation des ruminants contenant une substance biologiquement active et sa preparation
JPH07118170B2 (ja) * 1988-08-17 1995-12-18 アルプス電気株式会社 デイスク駆動装置
IT1256651B (it) * 1992-12-11 1995-12-12 Giancarlo Santus Composizione farmaceutica a rilascio controllato in sospensione liquida
WO1992001446A1 (fr) * 1990-07-20 1992-02-06 Aps Research Limited Formulations a liberation entretenue
EP0477135A1 (fr) 1990-09-07 1992-03-25 Warner-Lambert Company Microcapsules enduites sphéroidales mâchables et méthodes de leur préparation
US5464632C1 (en) 1991-07-22 2001-02-20 Prographarm Lab Rapidly disintegratable multiparticular tablet
FR2679451B1 (fr) * 1991-07-22 1994-09-09 Prographarm Laboratoires Comprime multiparticulaire a delitement rapide.
WO1994009762A1 (fr) * 1992-11-05 1994-05-11 Merck & Co., Inc. Dispositif d'administration de medicaments
FR2725623A1 (fr) * 1994-10-18 1996-04-19 Flamel Tech Sa Microcapsules medicamenteuses et/ou nutritionnelles pour administration per os
US5674529A (en) * 1995-06-06 1997-10-07 Church & Dwight Co., Inc. Alkalinizing potassium salt controlled release preparations
FR2771291B1 (fr) 1997-11-21 2000-02-25 Ethypharm Lab Prod Ethiques Spheroides, procede de preparation et compositions pharmaceutiques
FR2816840B1 (fr) * 2000-11-17 2004-04-09 Flamel Tech Sa Medicament a base de microcapsules d'anti-hyperclycemiant a liberation prolongee et son procede de preparation
FR2821745B1 (fr) 2001-03-09 2004-07-02 Ethypharm Lab Prod Ethiques Granules et granules enrobes au gout masque

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
US7906145B2 (en) 2002-04-09 2011-03-15 Flamel Technologies Oral pharmaceutical formulation in the form of aqueous suspension for modified release of active principle(s)
US7910133B2 (en) 2002-04-09 2011-03-22 Flamel Technologies Oral pharmaceutical formulation in the form of aqueous suspension of microcapsules for modified release of amoxicillin

Also Published As

Publication number Publication date
ZA200408412B (en) 2006-08-30
MXPA04009010A (es) 2004-11-26
AU2003242818B2 (en) 2008-12-18
WO2003077888A3 (fr) 2004-04-15
CN1642530A (zh) 2005-07-20
KR20040105773A (ko) 2004-12-16
IL163813A0 (en) 2005-12-18
FR2837100A1 (fr) 2003-09-19
IL163813A (en) 2010-06-30
US8507003B2 (en) 2013-08-13
US20050266078A1 (en) 2005-12-01
CA2479057A1 (fr) 2003-09-25
BR0308487A (pt) 2005-01-18
AU2003242818A1 (en) 2003-09-29
CA2479057C (fr) 2012-02-07
EP1485071A2 (fr) 2004-12-15
JP2005527522A (ja) 2005-09-15
WO2003077888A2 (fr) 2003-09-25

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Effective date: 20141128