WO2003077888A3 - Comprimes a base de microcapsules a liberation modifiee - Google Patents

Comprimes a base de microcapsules a liberation modifiee Download PDF

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Publication number
WO2003077888A3
WO2003077888A3 PCT/FR2003/000827 FR0300827W WO03077888A3 WO 2003077888 A3 WO2003077888 A3 WO 2003077888A3 FR 0300827 W FR0300827 W FR 0300827W WO 03077888 A3 WO03077888 A3 WO 03077888A3
Authority
WO
WIPO (PCT)
Prior art keywords
active principle
microcapsules
compression
prolonged
deformable
Prior art date
Application number
PCT/FR2003/000827
Other languages
English (en)
Other versions
WO2003077888A2 (fr
Inventor
Rafael Jorda
Pierre Autant
Original Assignee
Flamel Tech Sa
Rafael Jorda
Pierre Autant
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BR0308487-6A priority Critical patent/BR0308487A/pt
Priority to EP03744400A priority patent/EP1485071A2/fr
Priority to CA2479057A priority patent/CA2479057C/fr
Priority to AU2003242818A priority patent/AU2003242818B2/en
Priority to JP2003575941A priority patent/JP2005527522A/ja
Priority to MXPA04009010A priority patent/MXPA04009010A/es
Application filed by Flamel Tech Sa, Rafael Jorda, Pierre Autant filed Critical Flamel Tech Sa
Priority to KR10-2004-7014579A priority patent/KR20040105773A/ko
Priority to IL16381303A priority patent/IL163813A0/xx
Priority to US10/507,886 priority patent/US8507003B2/en
Publication of WO2003077888A2 publication Critical patent/WO2003077888A2/fr
Publication of WO2003077888A3 publication Critical patent/WO2003077888A3/fr
Priority to IL163813A priority patent/IL163813A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Le but de l'invention est de proposer un comprimé multi(micro)particulaire, comprenant un c ur de principe actif PA mécaniquement non déformable (cristal, granule), permettant la libération prolongée in vivo de ce PA, sans modification du profil de libération par la compression (microparticules non spécifiquement formulées pour la compression). Ce but est atteint par le comprimé selon l'invention, ô base de microcapsules réservoir, ô libération prolongée du PA, et :' formées chacune par un c ur non déformable comprenant du PA et recouvert par au moins une pellicule d'enrobage contrôlant la libération prolongée in vivo du PA, ' possédant une granulométrie comprise entre 50 et 1 000 µm ' et comprennent au moins une enveloppe externe de surenrobage ô base d'au moins un constituant organique déformable présentant une température de fusion comprise entre 40°C et 120°C (polyéthylèneglycol).Les microcapsules surenrobées résistantes ô la compression sont également visées en tant que telles par l'invention.
PCT/FR2003/000827 2002-03-18 2003-03-14 Comprimes a base de microcapsules a liberation modifiee WO2003077888A2 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
EP03744400A EP1485071A2 (fr) 2002-03-18 2003-03-14 Comprimes a base de microcapsules a liberation modifiee
CA2479057A CA2479057C (fr) 2002-03-18 2003-03-14 Comprimes a base de microcapsules a liberation modifiee
AU2003242818A AU2003242818B2 (en) 2002-03-18 2003-03-14 Compressed tablets comprising microcapsules with modified release
JP2003575941A JP2005527522A (ja) 2002-03-18 2003-03-14 マイクロカプセルをベースとした徐放性錠剤
MXPA04009010A MXPA04009010A (es) 2002-03-18 2003-03-14 Tabletas comprimidas a base de microcapsulas con liberacion modificada.
BR0308487-6A BR0308487A (pt) 2002-03-18 2003-03-14 Comprimidos à base de microcápsulas de liberação modificada
KR10-2004-7014579A KR20040105773A (ko) 2002-03-18 2003-03-14 마이크로캡슐을 포함하는 변형 방출형 압축 정제
IL16381303A IL163813A0 (en) 2002-03-18 2003-03-14 Modified-release tased on microcapsules
US10/507,886 US8507003B2 (en) 2002-03-18 2003-03-14 Compressed tablets comprising microcapsules with modified release
IL163813A IL163813A (en) 2002-03-18 2004-08-30 Modified-release tablets based on microcapsules

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR02/03336 2002-03-18
FR0203336A FR2837100B1 (fr) 2002-03-18 2002-03-18 Comprimes a bases de microcapsules a liberation modifiee

Publications (2)

Publication Number Publication Date
WO2003077888A2 WO2003077888A2 (fr) 2003-09-25
WO2003077888A3 true WO2003077888A3 (fr) 2004-04-15

Family

ID=27772222

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2003/000827 WO2003077888A2 (fr) 2002-03-18 2003-03-14 Comprimes a base de microcapsules a liberation modifiee

Country Status (13)

Country Link
US (1) US8507003B2 (fr)
EP (1) EP1485071A2 (fr)
JP (1) JP2005527522A (fr)
KR (1) KR20040105773A (fr)
CN (1) CN1642530A (fr)
AU (1) AU2003242818B2 (fr)
BR (1) BR0308487A (fr)
CA (1) CA2479057C (fr)
FR (1) FR2837100B1 (fr)
IL (2) IL163813A0 (fr)
MX (1) MXPA04009010A (fr)
WO (1) WO2003077888A2 (fr)
ZA (1) ZA200408412B (fr)

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US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
CA2480824A1 (fr) 2002-04-09 2003-10-16 Flamel Technologies Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee d'amoxicilline
WO2003084518A2 (fr) 2002-04-09 2003-10-16 Flamel Technologies Suspension orale de microcapsules de principes actifs
FR2842735B1 (fr) * 2002-07-26 2006-01-06 Flamel Tech Sa Microcapsules a liberation modifiee de principes actifs peu solubles pour l'administration per os
WO2005123134A2 (fr) * 2004-05-14 2005-12-29 Cadila Healthcare Limited Systeme d'administration a liberation controlee pour metformine
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FR2889810A1 (fr) * 2005-05-24 2007-02-23 Flamel Technologies Sa Forme medicamenteuse orale, microparticulaire, anti-mesurage
FR2881652B1 (fr) * 2005-02-08 2007-05-25 Flamel Technologies Sa Forme pharmaceutique orale microparticulaire anti-mesuage
CA2609618C (fr) * 2005-05-24 2016-01-05 Flamel Technologies Nouvelles formulations d'acide acetylsalicylique
WO2006131790A2 (fr) * 2005-06-09 2006-12-14 Flamel Technologies Composition pharmaceutique de ribavirine a administration par voie orale
WO2006133733A1 (fr) * 2005-06-13 2006-12-21 Flamel Technologies Forme posologique orale comportant un systeme anti-abus
US8652529B2 (en) 2005-11-10 2014-02-18 Flamel Technologies Anti-misuse microparticulate oral pharmaceutical form
FR2892937B1 (fr) * 2005-11-10 2013-04-05 Flamel Tech Sa Forme pharmaceutique orale microparticulaire anti-mesusage
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EP2044929A1 (fr) * 2007-10-04 2009-04-08 Laboratorios del Dr. Esteve S.A. Comprimés oraux à désintégration rapide
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EP2341708B1 (fr) 2010-01-05 2017-03-08 Irdeto B.V. Variantes de diffusion de signaux numériques dans un système d'accès conditionnel
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CA2856520C (fr) 2011-11-23 2021-04-06 Therapeuticsmd, Inc. Preparations et therapies de substitution pour hormonotherapie naturelle combinee
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
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US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
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EP3244881A4 (fr) * 2015-01-12 2018-08-15 Nano Pharmaceutical Laboratories LLC Microbilles multicouches à libération prolongée et leur procédés de fabrication
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CA3020153A1 (fr) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Composition pharmaceutique d'hormone steroide
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
UY37341A (es) 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
CN108029310A (zh) * 2017-12-25 2018-05-15 翁毅 一种向土壤中缓慢施加肥料的方法
JP7060711B2 (ja) 2018-01-16 2022-04-26 アプライド マテリアルズ インコーポレイテッド 金属酸化物でカプセル化された薬物組成物及びその調製方法
JP2022522270A (ja) 2019-03-01 2022-04-15 フラメル アイルランド リミテッド 食事摂取状態における改善された薬物動態を有するガンマ－ヒドロキシ酪酸塩組成物
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EP0207041A2 (fr) * 1985-06-12 1986-12-30 "Galephar" Comprimés pharmaceutiques permettant l'administration aisée de pellets, leur préparation et leur utilisation
WO1992001446A1 (fr) * 1990-07-20 1992-02-06 Aps Research Limited Formulations a liberation entretenue
WO1993001805A1 (fr) * 1991-07-22 1993-02-04 Laboratoires Prographarm Comprime multiparticulaire a delitement rapide
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WO1999026608A1 (fr) * 1997-11-21 1999-06-03 Laboratoires Des Produits Ethiques Ethypharm Spheroides, procede de preparation et compositions pharmaceutiques

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EP0202051A2 (fr) * 1985-05-06 1986-11-20 American Home Products Corporation Compositions thérapeutiques pour administration orale
EP0207041A2 (fr) * 1985-06-12 1986-12-30 "Galephar" Comprimés pharmaceutiques permettant l'administration aisée de pellets, leur préparation et leur utilisation
WO1992001446A1 (fr) * 1990-07-20 1992-02-06 Aps Research Limited Formulations a liberation entretenue
WO1993001805A1 (fr) * 1991-07-22 1993-02-04 Laboratoires Prographarm Comprime multiparticulaire a delitement rapide
WO1994009762A1 (fr) * 1992-11-05 1994-05-11 Merck & Co., Inc. Dispositif d'administration de medicaments
WO1996011675A2 (fr) * 1994-10-18 1996-04-25 Flamel Technologies Microcapsules medicamenteuses et/ou nutritionnelles pour administration per os
WO1999026608A1 (fr) * 1997-11-21 1999-06-03 Laboratoires Des Produits Ethiques Ethypharm Spheroides, procede de preparation et compositions pharmaceutiques

Also Published As

Publication number Publication date
IL163813A (en) 2010-06-30
US20050266078A1 (en) 2005-12-01
IL163813A0 (en) 2005-12-18
JP2005527522A (ja) 2005-09-15
FR2837100B1 (fr) 2004-07-23
US8507003B2 (en) 2013-08-13
CN1642530A (zh) 2005-07-20
KR20040105773A (ko) 2004-12-16
AU2003242818B2 (en) 2008-12-18
ZA200408412B (en) 2006-08-30
CA2479057A1 (fr) 2003-09-25
AU2003242818A1 (en) 2003-09-29
BR0308487A (pt) 2005-01-18
CA2479057C (fr) 2012-02-07
WO2003077888A2 (fr) 2003-09-25
FR2837100A1 (fr) 2003-09-19
EP1485071A2 (fr) 2004-12-15
MXPA04009010A (es) 2004-11-26

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