MX2014015900A - Formulaciones de progesterona. - Google Patents

Formulaciones de progesterona.


Publication number
MX2014015900A MX2014015900A MX2014015900A MX2014015900A MX 2014015900 A MX2014015900 A MX 2014015900A MX 2014015900 A MX2014015900 A MX 2014015900A MX 2014015900 A MX2014015900 A MX 2014015900A MX 2014015900 A MX2014015900 A MX 2014015900A
Prior art keywords
fatty acid
polyethylene glycol
micronized progesterone
Prior art date
Application number
Other languages
English (en)
Janice Louise Cacace
Peter H R Persicaner
Original Assignee
Therapeuticsmd Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201261661302P priority Critical
Priority to US201261662265P priority
Priority to US13/684,002 priority patent/US8633178B2/en
Application filed by Therapeuticsmd Inc filed Critical Therapeuticsmd Inc
Priority to PCT/US2013/023309 priority patent/WO2013112947A1/en
Priority to US13/843,362 priority patent/US20130338122A1/en
Priority to PCT/US2013/046442 priority patent/WO2013192248A1/en
Publication of MX2014015900A publication Critical patent/MX2014015900A/es



    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816Wall or shell material
    • A61K9/4825Proteins, e.g. gelatin


Se describen formulaciones farmacéuticas de uso oral en la terapia de reemplazo hormonal que comprenden progesterona ultramicronizada, en donde la progesterona ultramicronizada se combina con un excipiente adecuado. Los excipientes preferidos comprenden ésteres de ácidos grasos de cadena media-glicoles y un surfactante no iónico que comprende un éster de ácidos grasos de polietilenglicol. En algunas modalidades, los ésteres de ácidos grasos de C8 a C18 de glicerol y polietilenglicol son los surfactantes no iónicos preferidos.
MX2014015900A 2011-11-23 2013-01-25 Formulaciones de progesterona. MX2014015900A (es)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US201261661302P true 2012-06-18 2012-06-18
US201261662265P true 2012-06-20 2012-06-20
US13/684,002 US8633178B2 (en) 2011-11-23 2012-11-21 Natural combination hormone replacement formulations and therapies
PCT/US2013/023309 WO2013112947A1 (en) 2012-01-26 2013-01-25 Transdermal hormone replacement therapies
US13/843,362 US20130338122A1 (en) 2012-06-18 2013-03-15 Transdermal hormone replacement therapies
PCT/US2013/046442 WO2013192248A1 (en) 2012-06-18 2013-06-18 Progesterone formulations

Publications (1)

Publication Number Publication Date
MX2014015900A true MX2014015900A (es) 2015-07-17



Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014015900A MX2014015900A (es) 2011-11-23 2013-01-25 Formulaciones de progesterona.
MX2014015897A MX2014015897A (es) 2011-11-23 2013-06-18 Terapias de reemplazo hormonal transdermicas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2014015897A MX2014015897A (es) 2011-11-23 2013-06-18 Terapias de reemplazo hormonal transdermicas.

Country Status (9)

Country Link
US (3) US20130338122A1 (es)
EP (3) EP2861234B1 (es)
JP (2) JP6298460B2 (es)
AU (3) AU2013277235B2 (es)
BR (2) BR112014031837A2 (es)
CA (2) CA2876964A1 (es)
MX (2) MX2014015900A (es)
WO (2) WO2013192250A1 (es)
ZA (1) ZA201500212B (es)

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US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
MX2014006256A (es) 2011-11-23 2014-10-24 Therapeuticsmd Inc Formulaciones y terapias de reemplazo hormonal de combinacion naturales.
MX2014015900A (es) 2012-06-18 2015-07-17 Therapeuticsmd Inc Formulaciones de progesterona.
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US20170216310A1 (en) 2014-10-22 2017-08-03 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
JP2017509630A (ja) * 2014-03-28 2017-04-06 セラピューティックスエムディー インコーポレーテッドTherapeuticsmd, Inc. プロゲステロン製剤
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