ATE461681T1 - Verfahren und vorrichtungen für die verzögerte freisetzung von mehreren arzneimitteln - Google Patents

Verfahren und vorrichtungen für die verzögerte freisetzung von mehreren arzneimitteln

Info

Publication number
ATE461681T1
ATE461681T1 AT04760436T AT04760436T ATE461681T1 AT E461681 T1 ATE461681 T1 AT E461681T1 AT 04760436 T AT04760436 T AT 04760436T AT 04760436 T AT04760436 T AT 04760436T AT E461681 T1 ATE461681 T1 AT E461681T1
Authority
AT
Austria
Prior art keywords
multiple drugs
methods
devices
sustained release
delivery device
Prior art date
Application number
AT04760436T
Other languages
English (en)
Inventor
Eyal Ron
Rober Langer
William Crowley
Original Assignee
Gen Hospital Corp
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp, Massachusetts Inst Technology filed Critical Gen Hospital Corp
Application granted granted Critical
Publication of ATE461681T1 publication Critical patent/ATE461681T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
    • A61F6/08—Pessaries, i.e. devices worn in the vagina to support the uterus, remedy a malposition or prevent conception, e.g. combined with devices protecting against contagion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
    • A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
    • A61F6/142—Wirelike structures, e.g. loops, rings, spirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
AT04760436T 2003-04-29 2004-04-29 Verfahren und vorrichtungen für die verzögerte freisetzung von mehreren arzneimitteln ATE461681T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46631803P 2003-04-29 2003-04-29
US47357903P 2003-05-27 2003-05-27
PCT/US2004/013172 WO2004096151A2 (en) 2003-04-29 2004-04-29 Methods and devices for the sustained release of multiple drugs

Publications (1)

Publication Number Publication Date
ATE461681T1 true ATE461681T1 (de) 2010-04-15

Family

ID=33423604

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04760436T ATE461681T1 (de) 2003-04-29 2004-04-29 Verfahren und vorrichtungen für die verzögerte freisetzung von mehreren arzneimitteln

Country Status (8)

Country Link
US (7) US7833545B2 (de)
EP (1) EP1620060B1 (de)
JP (1) JP4898431B2 (de)
AT (1) ATE461681T1 (de)
AU (1) AU2004233997C1 (de)
CA (1) CA2523859C (de)
DE (1) DE602004026173D1 (de)
WO (1) WO2004096151A2 (de)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6764505B1 (en) 2001-04-12 2004-07-20 Advanced Cardiovascular Systems, Inc. Variable surface area stent
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
US7169178B1 (en) * 2002-11-12 2007-01-30 Advanced Cardiovascular Systems, Inc. Stent with drug coating
US20050095245A1 (en) 2003-09-19 2005-05-05 Riley Thomas C. Pharmaceutical delivery system
BRPI0513141A (pt) 2004-07-09 2008-04-29 Population Council Inc composição para anel vaginal, e, processo de contracepção a longo prazo
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
EP1827328B1 (de) * 2004-12-14 2011-08-17 Poly-Med, Inc. Intravaginale ringnetzvorrichtung
WO2007143607A2 (en) 2006-06-02 2007-12-13 Pear Tree Women's Health Care Method of treating atrophic vaginitis
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
BRPI0713203A2 (pt) * 2006-07-12 2012-04-03 Controlled Therapeutics Scotland Ltda inserto, métodos, embalagem, dispositivo recuperável e dispositivo inserìvel
GB0620685D0 (en) 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
WO2008074153A1 (en) 2006-12-18 2008-06-26 Electronic Dietary Foods Inc. Device for delivery of a substance
WO2009061569A1 (en) * 2007-11-05 2009-05-14 Repros Therapeutics Inc. Compositions and methods for treating dysfunctional uterine bleeding
EP2057972A1 (de) * 2007-11-07 2009-05-13 N.V. Organon Intrauterine Vorrichtung
ES2365552T3 (es) * 2007-11-22 2011-10-06 Bayer Oy Sistema de administración vaginal.
EP2062568A1 (de) * 2007-11-22 2009-05-27 Bayer Schering Pharma Oy System zur vaginalen Freisetzung
ES2645630T3 (es) 2008-02-04 2017-12-07 Ferring B.V. Anillos intravaginales monolíticos que comprenden progesterona y métodos de fabricación y usos de los mismos
WO2009129459A1 (en) * 2008-04-18 2009-10-22 Combinent Biomedical Systems, Inc. Devices that include ethylene-vinyl acetate copolymers and methods of making and using same
TWI477276B (zh) 2008-04-28 2015-03-21 Repros Therapeutics Inc 抗黃體素給藥方案
US9034365B2 (en) 2008-05-20 2015-05-19 Poly-Med, Inc. Biostable, multipurpose, microbicidal intravaginal devices
EP2140860A1 (de) * 2008-07-03 2010-01-06 Bayer Schering Pharma Oy Verbessertes Verhütungsverfahren
US20100040671A1 (en) * 2008-08-12 2010-02-18 Ahmed Salah U Intravaginal Devices With a Rigid Support, Methods of Making, and Uses Thereof
WO2010054296A2 (en) * 2008-11-07 2010-05-14 Combinent Biomedical Systems, Inc. Devices and methods for treating and/or preventing diseases
FI121000B (fi) * 2008-11-19 2010-06-15 Bayer Schering Pharma Oy Intravaginaalinen antojärjestelmä ja menetelmä sen valmistamiseksi
US8568374B2 (en) * 2009-05-04 2013-10-29 Merck Sharp & Dohme B.V. Intrauterine system
EP4108216A1 (de) 2009-06-03 2022-12-28 Forsight Vision5, Inc. Wirkstofffreisetzung im vorderen augensegment
CA2767967C (en) 2009-07-21 2014-10-21 The Population Council, Inc. Multi-layered gradient vaginal ring
BR112012019725A2 (pt) * 2010-02-08 2020-11-10 Tao Tom Du usos de uma composição farmacêutica e uso de pelo menos um progestogênio
RU2648827C2 (ru) * 2010-03-28 2018-03-28 Эвестра, Инк. Внутривлагалищное устройство для доставки лекарственного средства
WO2011146483A1 (en) 2010-05-17 2011-11-24 Aerie Pharmaceuticals, Inc. Drug delivery devices for delivery of ocular therapeutic agents
SG10201504864UA (en) * 2010-06-22 2015-07-30 Teva Womens Health Inc Intravaginal devices comprising anticholinergic agents, and methods of making thereof
US8580294B2 (en) 2010-10-19 2013-11-12 International Partnership For Microbicides Platinum-catalyzed intravaginal rings
AU2011325975B2 (en) * 2010-11-12 2015-11-26 The University Of Utah Research Foundation Intravaginal devices for controlled delivery of lubricants
KR101263916B1 (ko) 2011-01-11 2013-05-13 이장희 성 호르몬 방출 장치 및 이를 이용한 동물 피임 및 발정 유도 방법
WO2012121811A1 (en) * 2011-03-04 2012-09-13 Arstat, Inc. Treatment of excessive menstrual blood loss by intravaginal administration of low doses of antifibronlytic or hemostatic agent
CN103648482B (zh) 2011-07-15 2018-01-02 根特大学 阴道内递送系统
KR102192603B1 (ko) 2011-09-14 2020-12-17 포사이트 비젼5, 인크. 안내 삽입물 장치 및 방법
EP2755634A4 (de) * 2011-09-14 2015-06-10 Royer Biomedical Inc Bioresorbierbare arzneimittelfreisetzende matrizen auf basis vernetzter polysaccharide und dosierungsformen davon für verzögerte/gesteuerte wirkstoffabgabe
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
JP6285866B2 (ja) 2011-11-23 2018-02-28 セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． 天然複合ホルモン補充製剤および療法
US20130166931A1 (en) * 2011-12-23 2013-06-27 Lsi Corporation Reducing power consumption of memory
US9854831B2 (en) 2012-01-20 2018-01-02 Altria Client Services Llc Oral product
CN102754907B (zh) 2012-01-20 2015-06-24 奥驰亚客户服务公司 口腔用产品
CN103040090B (zh) * 2012-01-20 2016-03-30 奥驰亚客户服务公司 脱除烟草的口腔用产品
CN102754908B (zh) 2012-01-20 2015-06-10 奥驰亚客户服务公司 口腔用烟草产品
CN103039688B (zh) 2012-01-20 2016-01-06 奥驰亚客户服务公司 口腔用产品
DE102012009057A1 (de) * 2012-05-09 2013-11-14 Dr. Arabin GmbH & Co. KG Rotationspessar mit zusätzlicher Wirkstoffkomponente
EA030444B1 (ru) 2012-05-31 2018-08-31 Репрос Терапьютикс Инк. Способ лечения прогестеронзависимого состояния
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9750636B2 (en) 2012-10-26 2017-09-05 Forsight Vision5, Inc. Ophthalmic system for sustained release of drug to eye
EP2914268B1 (de) 2012-11-02 2018-07-04 Repros Therapeutics Inc. Verfahren und zusammensetzungen zur behandlung von progesteronbedingten zuständen
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10137031B2 (en) 2013-11-14 2018-11-27 International Partnership For Microbicides, Inc. Combination therapy intravaginal rings
AU2015264003A1 (en) 2014-05-22 2016-11-17 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
HUE040176T2 (hu) 2014-06-28 2019-02-28 Laboratorios Andromaco S A Elnyújtott, hosszantartó és folyamatos felszabadulású progeszteront tartalmazó méhnyakpesszárium koraszülés megelõzésére
CN105277633B (zh) * 2014-07-26 2017-06-23 浙江仙琚制药股份有限公司 一种炔诺酮衍生物及其中间体的杂质检测分析方法
WO2016018993A1 (en) 2014-07-29 2016-02-04 Therapeuticsmd, Inc. Transdermal cream
WO2016020901A1 (en) 2014-08-07 2016-02-11 Acerta Pharma B.V. Methods of treating cancers, immune and autoimmune diseases, and inflammatory diseases based on btk occupancy and btk resynthesis rate
EP3017809A1 (de) 2014-11-07 2016-05-11 Ferring B.V. Arzneimittelvorrichtung mit Quinagolid
DK3247327T3 (da) 2015-01-21 2019-10-28 Bayer Oy Lægemiddeladministrationssystem, der omfatter en nonsteroid antiinflammatorisk (nsaid) og en progestogen forbindelse, og fremgangsmåder til fremstilling heraf
EP3250183A1 (de) * 2015-01-30 2017-12-06 Li Galli B.V. Vaginale arzneimittelabgabevorrichtung
EP3283004A4 (de) 2015-04-13 2018-12-05 Forsight Vision5, Inc. Augeneinsatzzusammensetzung aus einem semikristallinen oder kristallinen pharmazeutischen wirkstoff
EP3294300A1 (de) * 2015-05-13 2018-03-21 Bayer Oy Vorrichtung zur freisetzung eines langwirkenden arzneimittels und dessen verwendung zur verhütung
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
GB201517523D0 (en) * 2015-10-05 2015-11-18 Ostara Biomedical Ltd Methods and compositions for managing reproduction
EP3402471A4 (de) * 2016-01-12 2019-08-28 Repros Therapeutics Inc. Kombinationstherapie aus transclomiphen und progesteronrezeptorantagonist zur behandlung von hormonabhängigen erkrankungen
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
BR112018070199A2 (pt) 2016-04-01 2019-01-29 Therapeuticsmd Inc composição farmacêutica de hormônio esteroide
GB201708224D0 (en) 2017-05-23 2017-07-05 Juniper Pharmaceuticals Uk Ltd Device
FR3070619A1 (fr) * 2017-09-01 2019-03-08 Ab7 Innovation Piece moulee monolithique en matrice multiple pour la diffusion d’actifs et son procede d’obtention
CN111801072A (zh) 2017-10-27 2020-10-20 锐诺维公司 用于训练盆底肌的装置、系统和方法
CN108186553B (zh) * 2018-02-13 2020-10-02 广东药科大学 一种黄体酮长效栓剂及其制备方法
CA3094259A1 (en) * 2018-04-10 2019-10-24 Ligalli B.V. Vaginal systemic drug delivery
AU2019261454A1 (en) * 2018-04-27 2020-12-03 Evestra, Inc. Estrogen prodrugs and methods of administering estrogen prodrugs
BR112020023983A2 (pt) 2018-05-24 2021-02-23 Celanese Eva Performance Polymers Llc dispositivo implantável para liberação prolongada de um composto de fármaco macromolecular
MX2020012459A (es) 2018-05-24 2021-04-28 Celanese Eva Performance Polymers Llc Dispositivo implantable para liberacion sostenida de un compuesto de farmaco macromolecular.
CA3135362A1 (en) * 2019-03-29 2020-10-08 Bridget MARTELL Eva segmented intravaginal rings containing progesterone
CN113164383B (zh) * 2019-10-12 2022-08-12 国家卫生健康委科学技术研究所 用于黄体支持的阴道缓释给药系统及其制备方法与应用
FR3107203B1 (fr) * 2020-02-14 2023-11-24 Ab7 Innovation Matrice solide composite pour la délivrance prolongée d’actifs
USD935018S1 (en) * 2020-04-07 2021-11-02 The Population Council, Inc. Contraceptive
WO2023031218A1 (en) 2021-08-31 2023-03-09 Ferring B.V. Diagnosis and treatment of ectopic endometriosis

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1945275U (de) * 1965-04-30 1966-09-01 Ortho Pharma Corp Intrauterine vorrichtung zur empfaengnisverhuetung.
US3454004A (en) * 1967-08-18 1969-07-08 Holland Rantos Co Inc Intrauterine contraceptive device
US3545439A (en) * 1968-01-04 1970-12-08 Upjohn Co Medicated devices and methods
NL6903028A (de) * 1969-02-26 1970-08-28
US4069307A (en) * 1970-10-01 1978-01-17 Alza Corporation Drug-delivery device comprising certain polymeric materials for controlled release of drug
US3903880A (en) * 1972-08-17 1975-09-09 Alza Corp Intrauterine device for managing the reproductive process
US3920805A (en) * 1971-12-09 1975-11-18 Upjohn Co Pharmaceutical devices and method
US3938515A (en) * 1971-12-20 1976-02-17 Alza Corporation Novel drug permeable wall
US3708511A (en) * 1972-01-18 1973-01-02 Organon Novel {66 -steroids of the oestrane series
NL7204025A (de) * 1972-03-24 1973-09-26
US3780935A (en) * 1972-07-10 1973-12-25 Lukacs & Jacoby Ass Serum separating method
NL7210262A (de) * 1972-07-26 1974-01-29
US4016251A (en) * 1972-08-17 1977-04-05 Alza Corporation Vaginal drug dispensing device
US3963119A (en) * 1973-10-13 1976-06-15 Lucaks And Jacoby Associates Serum separating apparatus
US4043928A (en) * 1973-10-31 1977-08-23 Lukacs And Jacoby Associates Serum separating composition of matter
US4155991A (en) * 1974-10-18 1979-05-22 Schering Aktiengesellschaft Vaginal ring
IL48277A (en) * 1974-10-18 1978-03-10 Schering Ag Vaginal ring
US4093709A (en) * 1975-01-28 1978-06-06 Alza Corporation Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates)
US4144317A (en) * 1975-05-30 1979-03-13 Alza Corporation Device consisting of copolymer having acetoxy groups for delivering drugs
US4096860A (en) * 1975-10-08 1978-06-27 Mclaughlin William F Dual flow encatheter
US3995633A (en) * 1975-12-02 1976-12-07 The Procter & Gamble Company Vaginal Medicament dispensing device
US3995634A (en) * 1975-12-02 1976-12-07 The Procter & Gamble Company Vaginal cavity dispensing means and method
US4219426A (en) * 1976-03-19 1980-08-26 Organon Teknika B.V. Dialysis device
US4237885A (en) * 1978-10-23 1980-12-09 Alza Corporation Delivery system with mated members for storing and releasing a plurality of beneficial agents
US4292965A (en) * 1978-12-29 1981-10-06 The Population Council, Inc. Intravaginal ring
DE3040978A1 (de) * 1980-10-28 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Vaginalring
US4484559A (en) * 1982-03-01 1984-11-27 Mcdermott Incorporated Apparatus for removing material such as concrete from underwater pipelines
DE3214667C2 (de) * 1982-04-21 1985-07-18 Akzo Gmbh, 5600 Wuppertal Zusammengesetzter Körper für die Langzeitabgabe von Wirkstoffen
CA1223831A (en) 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
US4629449A (en) * 1982-07-29 1986-12-16 Alza Corporation Vaginal dispenser for dispensing beneficial hormone
NL8301035A (nl) * 1983-03-23 1984-10-16 Organon Teknika Bv Macromoleculair materiaal met carbonylgroepen geschikt als sorbent voor stikstofverbindingen.
US4558996A (en) * 1983-06-30 1985-12-17 Organon Teknika Corporation Easy load peristaltic pump
US4484599A (en) 1983-09-23 1984-11-27 Organon Teknika Corporation Pinch-type pressure- or flow-regulating valve
ZA857643B (en) * 1984-10-12 1986-05-28 Akzo Nv Release system for two or more active substances
US4596576A (en) * 1984-10-12 1986-06-24 Akzo N.V. Release system for two or more active substances
US4645502A (en) * 1985-05-03 1987-02-24 Alza Corporation Transdermal delivery of highly ionized fat insoluble drugs
US4762717A (en) * 1986-03-21 1988-08-09 The General Hospital Corporation Continuous delivery of luteinizing hormone releasing hormone compositions in combination with sex steroid delivery for use as a contraceptive
SE8602666D0 (sv) * 1986-06-16 1986-06-16 Leo Ab Intravaginal devices
US4938759A (en) 1986-09-02 1990-07-03 Alza Corporation Transdermal delivery device having a rate controlling adhesive
CA1331563C (en) 1987-08-03 1994-08-23 Gaylen M. Zentner Device for the controlled release of drugs with donnan-like modulation by charged insoluble resins
ES2054784T3 (es) * 1987-08-08 1994-08-16 Akzo Nv Un metodo para la fabricacion de un implante.
US5474783A (en) * 1988-03-04 1995-12-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
NZ228285A (en) * 1988-03-11 1991-08-27 Teikoku Seiyaku Kk Pharmaceutical composition comprising a polypeptide and adapted for intravaginal administration
US5034229A (en) * 1988-12-13 1991-07-23 Alza Corporation Dispenser for increasing feed conversion of hog
US5002540A (en) * 1989-05-22 1991-03-26 Warren Kirschbaum Intravaginal device and method for delivering a medicament
US5252334A (en) * 1989-09-08 1993-10-12 Cygnus Therapeutic Systems Solid matrix system for transdermal drug delivery
HU208495B (en) * 1990-06-27 1993-11-29 Alkaloida Vegyeszeti Gyar Process for producing retarde pharmaceutical compositions
IE67345B1 (en) 1991-03-12 1996-03-20 Akzo Nv Low dose dry pharmaceutical preparations
US5340585A (en) * 1991-04-12 1994-08-23 University Of Southern California Method and formulations for use in treating benign gynecological disorders
US5211952A (en) * 1991-04-12 1993-05-18 University Of Southern California Contraceptive methods and formulations for use therein
US5302397A (en) * 1991-11-19 1994-04-12 Amsden Brian G Polymer-based drug delivery system
US6013853A (en) * 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
CA2094217A1 (en) * 1992-04-17 1993-10-18 Yasutaka Igari Transmucosal therapeutic composition
CA2098889A1 (en) * 1992-07-06 1994-01-07 Takashi Chinuki Slow-releasing medicated resin moldings and process for producing the same
US5482702A (en) * 1993-04-27 1996-01-09 Church & Dwight Co., Inc. Hydrophilic polymer-coated microcrystallites of bicarbonate salt
US5919478A (en) * 1993-06-25 1999-07-06 Alza Corporation Incorporating poly-N-vinyl amide in a transdermal system
GB2282384B8 (en) * 1993-08-18 1997-09-04 Europ Economic Community Drug delivery agents incorporating mitomycin
US5543150A (en) * 1993-09-15 1996-08-06 Columbia Laboratories, Inc. Method of progesterone delivery and affect thereof
WO1995017896A1 (fr) 1993-12-27 1995-07-06 Akzo Nobel N.V. Preparation pour absorption par voie percutanee
FR2717688B1 (fr) * 1994-03-28 1996-07-05 Lhd Lab Hygiene Dietetique Système matriciel transdermique d'administration d'un oestrogène et/ou un progestatif à base d'EVA.
FI97944C (fi) 1994-07-05 1997-03-25 Leiras Oy Vaikuttavaa ainetta luovuttava laite
US5681568A (en) * 1994-08-19 1997-10-28 Cambridge Neuroscience, Inc. Device for delivery of substances and methods of use thereof
US5593965A (en) * 1994-10-20 1997-01-14 Creighton University Anti-tumor effects of GnRH-III
IL116433A (en) * 1994-12-19 2002-02-10 Galen Chemicals Ltd INTRAVAGINAL DRUG DELIVERY DEVICES FOR THE ADMINISTRATION OF 17β-OESTRADIOL PRECURSORS
EP0818990A1 (de) * 1995-04-03 1998-01-21 Abbott Laboratories Homogene mischungen aus niedrigschmelzenden arzneistoffen und additiven zur verzögerten wirkstoffeingabe
US5601839A (en) * 1995-04-26 1997-02-11 Theratech, Inc. Triacetin as a penetration enhancer for transdermal delivery of a basic drug
US6572879B1 (en) * 1995-06-07 2003-06-03 Alza Corporation Formulations for transdermal delivery of pergolide
ATE207736T1 (de) * 1995-07-04 2001-11-15 Akzo Nobel Nv Ringförmige vorrichtung
FR2739032B1 (fr) * 1995-09-27 1997-11-21 Lhd Lab Hygiene Dietetique Systeme matriciel transdermique d'administration d'un oestrogene et/ou d'un progestatif a base d'eva, procede de preparation et utilisation en therapeutique
US5780435A (en) * 1995-12-15 1998-07-14 Praecis Pharmaceuticals Incorporated Methods for treating prostate cancer with LHRH-R antagonists
US6156331A (en) * 1996-02-02 2000-12-05 Alza Corporation Sustained delivery of an active agent using an implantable system
US5869081A (en) * 1996-06-28 1999-02-09 The Population Council Progesterone vaginal ring for treatment of infertility
US6139873A (en) * 1996-07-10 2000-10-31 Cedars-Sinai Medical Center Combined pharmaceutical estrogen-androgen-progestin
US5972372A (en) * 1996-07-31 1999-10-26 The Population Council, Inc. Intravaginal rings with insertable drug-containing core
US5945128A (en) * 1996-09-04 1999-08-31 Romano Deghenghi Process to manufacture implants containing bioactive peptides
ES2221019T3 (es) * 1996-10-31 2004-12-16 Takeda Chemical Industries, Ltd. Preparacion de liberacion mantenida.
US5985861A (en) * 1996-11-04 1999-11-16 Columbia Laboratories, Inc. Progesterone for treating or reducing ischemia
JPH10138432A (ja) * 1996-11-14 1998-05-26 Teijin Ltd 磁気テープ用二軸配向積層ポリエステルフィルム
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
JPH10279499A (ja) * 1997-04-04 1998-10-20 Takeda Chem Ind Ltd 子宮粘膜適用製剤
IL123813A0 (en) 1997-04-11 1998-10-30 Akzo Nobel Nv Drug delivery system for two or more active substances
AR012448A1 (es) * 1997-04-18 2000-10-18 Ipsen Pharma Biotech Composicion en forma de microcapsulas o de implantes que comprende un excipiente biodegradable, polimero o co-polimero, o una mezcla de talesexcipientes, y una sustancia activa o una mezcla de sustancias activas, procedimiento para la preparacion de una sustancia soluble en agua de elevada
US6197327B1 (en) * 1997-06-11 2001-03-06 Umd, Inc. Device and method for treatment of dysmenorrhea
US6416779B1 (en) * 1997-06-11 2002-07-09 Umd, Inc. Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections
US6905701B2 (en) * 1997-06-11 2005-06-14 Umd, Inc. Formulations for transmucosal vaginal delivery of bisphosphonates
US6572874B1 (en) * 1998-05-15 2003-06-03 Umd, Inc. Vaginal delivery of bisphosphonates
US6039968A (en) 1997-06-24 2000-03-21 Hoechst Marion Roussel Intravaginal drug delivery device
US5941844A (en) * 1997-11-17 1999-08-24 Alza Corporation Method and device for controlling mammalian reproductive cycle
EP1041974B1 (de) * 1997-12-30 2006-10-11 Alza Corporation Verabreichungssystem für wirkstoffe mit einem membranstöpsel
USD442688S1 (en) * 1998-01-28 2001-05-22 N.V. Organon Vaginal ring applicator
EP0940678A1 (de) 1998-03-02 1999-09-08 Akzo Nobel N.V. Analytisches Testgerät
US5945123A (en) * 1998-04-02 1999-08-31 K-V Pharmaceutical Company Maximizing effectiveness of substances used to improve health and well being
WO1999056934A1 (en) * 1998-05-01 1999-11-11 Fei Enterprises, Ltd. Method for injection molding manufacture of controlled release devices
US6218367B1 (en) * 1998-09-15 2001-04-17 Organomed Corporation Paclitaxel-carbohydrate conjugates: design, synthesis and biological evaluations
US6143314A (en) * 1998-10-28 2000-11-07 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
US6159491A (en) * 1999-02-12 2000-12-12 Biovector Technologies, Inc. Prolonged release bioadhesive vaginal gel dosage form
WO2001014478A1 (fr) 1999-08-25 2001-03-01 Dai-Ichi Kogyo Seiyaku Co., Ltd Composition de resine moulee sous forme de gel, produit chimique sous forme de gel volatil emballe, et processus de production de celui-ci.
US6264973B1 (en) * 1999-08-26 2001-07-24 Fei Enterprises, Ltd. Apparatus and method for anesthetizing the cervical region of a female
US7052714B1 (en) 1999-10-13 2006-05-30 Senju Pharmaceutical Co., Ltd Ophthalmic adhesive preparations for percutaneous adsorption
US6264981B1 (en) * 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
GB0102342D0 (en) * 2001-01-30 2001-03-14 Smithkline Beecham Plc Pharmaceutical formulation
US6687178B1 (en) * 2001-02-23 2004-02-03 Western Digital (Fremont), Inc. Temperature dependent write current source for magnetic tunnel junction MRAM

Also Published As

Publication number Publication date
DE602004026173D1 (de) 2010-05-06
AU2004233997B9 (en) 2013-01-10
WO2004096151A3 (en) 2006-05-11
EP1620060A4 (de) 2007-11-28
US20120202742A1 (en) 2012-08-09
US7838024B2 (en) 2010-11-23
AU2004233997A1 (en) 2004-11-11
CA2523859A1 (en) 2004-11-11
AU2004233997B8 (en) 2010-01-14
JP2007525461A (ja) 2007-09-06
US20080248017A1 (en) 2008-10-09
US7829112B2 (en) 2010-11-09
AU2004233997C1 (en) 2014-01-30
US20080286322A1 (en) 2008-11-20
WO2004096151A2 (en) 2004-11-11
EP1620060A2 (de) 2006-02-01
US7833545B2 (en) 2010-11-16
AU2004233997B2 (en) 2009-12-17
US20090060982A1 (en) 2009-03-05
CA2523859C (en) 2011-08-02
US7883718B2 (en) 2011-02-08
US20080286339A1 (en) 2008-11-20
US20090274654A1 (en) 2009-11-05
US20070196433A1 (en) 2007-08-23
EP1620060B1 (de) 2010-03-24
JP4898431B2 (ja) 2012-03-14

Similar Documents

Publication Publication Date Title
ATE461681T1 (de) Verfahren und vorrichtungen für die verzögerte freisetzung von mehreren arzneimitteln
MXPA05008648A (es) Usos y formulaciones para la aplicacion transdermica o transmucosa de agentes activos.
MX2022006681A (es) Sistema de suministro transdermico de donepezilo.
TW200505402A (en) Ophthalmic drug delivery device
NO993520L (no) Doseringsformer og fremgangsmÕte for Õ bedre erektil dysfunksjon
BR0311443A (pt) Método e dispositivo para controlar farmacocinética de droga
MA27586A1 (fr) Systemes de distribution pharmaceutiques et/ou cosmetiques topiques
UY27532A1 (es) Forma de dosificación de liberación controlada dual.
TW200642704A (en) Oral drug delivery system and methods of use thereof
MX2010006840A (es) Aparato y métodos para suministrar agentes terapeuticos.
ATE450252T1 (de) Arzneimittel-mikroteilchen
MY167123A (en) Conveniently implantable sustained release drug compositions
TW200605915A (en) Drug delivery compositions
TNSN01053A1 (fr) Compositions nouvelles comprenant un agoniste partiel des recepteurs de nicotine et un agent analgesique
ECSP066575A (es) Antagonistas del receptor b1 de bradiquinina
BR0112054A (pt) Composição formadora de micelas, e métodos para a administração e a proteção de um agente terapêutico
SG159559A1 (en) Pharmaceutical product
AR033042A1 (es) Terapia de reemplazo hormonal
TW200509998A (en) Controlled release of highly soluble agents
HK1060691A1 (en) Ion-strength independent sustained release pharmaceutical formulation
DE60011748D1 (de) Methoden und zusammenstellungen zur behandlung der weiblichen sexuellen dysfunktion
AR034142A1 (es) Una composicion farmaceutica, metodo para fabricar un medicamento en base a dicha composicion y uso de la composicion
DE502005002624D1 (de) Nahrungsergänzungsmittelabgabevorrichtung
AR027677A1 (es) Una composicion farmaceutica terapeutica que comprende camptotecina y ciclofosfamida para el tratamiento del cancer
WO2005011589A3 (en) Drug delivery methods and devices

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties