US3545439A - Medicated devices and methods - Google Patents

Medicated devices and methods Download PDF

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US3545439A
US3545439A US3545439DA US3545439A US 3545439 A US3545439 A US 3545439A US 3545439D A US3545439D A US 3545439DA US 3545439 A US3545439 A US 3545439A
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Gordon W Duncan
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Upjohn Co
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Upjohn Co
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61DVETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/06Contraceptive devices; Pessaries; Applicators therefor for use by females
    • A61F6/08Pessaries, i.e. devices worn in the vagina to support the uterus, remedy a malposition or prevent conception, e.g. combined with devices protecting against contagion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/557Eicosanoids, e.g. leukotrienes or prostaglandins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins Analogues or derivatives thereof

Description

United States atent [72] Inventor Gordon W. Duncan 2,423,475 7/1947 Rice et a1 424/28 Kalamazoo, Michigan 3,442,266 5/1969 Krejciet a1. 128/130 [2]] App]. No. 696,011 3,055,297 9/1962 Leeds...... 424/28 [22] Wed 2 Primary Exuminer- Adele M. Eager [45] Pau :med Attorneys-Joseph K. Andonian, John Kekich and Edward G. [73] Assignee The Up ohn Company Jones Kalamazoo, Michigan a corporation of Delaware [54] MEDICATED DEVICES AND METHODS 19 clalms4nrawmg Flgs' ABSTRACT: An improved resilient annular device for in- [52] US. Cl 128/260, travaginal placement and retention as required and formed of 3/ 128/130 128/270 260/75 a compatible nonabsorbable polymeric substance such as an [51] Int. Cl A6lm 7/00 organopolysiloxane nylon, natural or Synthetic rubber, [50] Field of Search 128/130, dacron, teflon, polyurethane and polyethylene and containing 131, 128, 129,334, 270, 156, 268, 260, 1; 24/ an effective amount of a medicament which is capable of 27, 28; 264/337; 260/75, 858; 3/ passage through the drug-permeable polymeric material. The References Cited device is useful to provide a readily inserted, readily retained and readily removable source of continued medication for UNITED STATES PATENTS sustained beneficial effects in female mammals, human and 2,017,596 1/1936 Hoffman 424/28 animal.

. MEDICATED DEYICES ANDMETHODS BRIEF SUMMARY OF THE INVENTION This invention relates to pharmaceutical devices and methods of their use, more particularly to sucha device for intravaginal placement in the form of a resilient medicated ring comprised of acompatible nonabsorable polymeric material and an effective amount of a diffusible medicament. The invention relates also to methods of providing continuous medication, during a predetermined medication period via the vagina in female mammals, human and animal, for example dogs, sheep, cattle, horses, and rats.

BRIEF DESCRIPTION OF THE DRAWING DETAILED DESCRIPTION It has beenfound thatt he device according to this invention provides sufiiciently resilient characteristics so that upon tensing for ready manual or mechanical insertion in the vaginal tract there will be relative ease of handling. Upon 'releaseof tension, the device will resume the annular form necessary for providing retentive contact within the vaginal area. Proper retention is obtained upon placement in the vaginain accordance with FIG. 3 and when properly placed, the ring fits securely and comfortably between the rear wall of the vagina and the upper edge, of the pubic bone. In that position the medicated device can'be readily inserted and is readily retained during the desired period of continued medication. when it is desired that medication cease, the ring is readily removed in a reverse fashion to insertion.

'As aforesaid, "the resilient annular device is formed of a compatible drug-permeable polymeric materiall As used herein, the word compatible means compatible both with the environment of the vaginal tract in that there is no break-' down of the annular tensile nature of the device due to the contents of the vagina, nor isthere any absorption of the polymeric material itself, only the medication being absorbed ing to known methods from polyisocyanate and polyhydroxyl material. The .polyhydroxyl materials, for example polyesters, polyethers and the like, are reacted with isocyanates to yield rubberlike products for use as millalble gums or in casting systems or as thermo processable res-ins. See U.S. Pat. Nos. 2,87 1,218 and 3,015,650. Another exemplary polymer is polyethylene, prepared by polymerization of ethylene, usually prepared from natural gas or the cracking of crude oil. Modern Plastics Encyclopedia for 1968, Sept, 1967, Vol. 45, No. la,"Mc,Graw-Hill, New York, New York, U.S.A. describes the preparation of the aforesaid suitable plastic materials, especially in reference to their molding qualities, compression molding temperatures, and'compression molding pressures. Details on theaforesaid polymers are given in the plastic properties chart of the aforesaid Encyclopedia, pages 29 through 46, inclusive. In rcference-to'the nonabsorbability and nontoxic nature of the aforesaid polymeric material, U.S. Pat. No. 3,272,204 refers to the use of vinyon N, nylon, orlon, dacron, teflon, and the like as nonabsorbable, reinforcing strands for the preparation ofprostheses'. Such strands have the advantage that they do not become a pant of the body tissues. So it is with the improyed resilient annular device of the present invention, which is particularly advantageous because of its ready insertion and ready retentionbut does not become or form any part of the tissue of the female'mammal utilizing the device, for example human and animal, such as dogs, cattle,

and horses. In this respect, the present annular device, with its medication contained therein for continued medication as desired, is greatly superior to implantates, which of necessity are placed within the actual'body tissues, such placement often requiring at least minor surgery for both insertion and removal, especially if encapsulated- As aforesaid, the device, properly sizedand fitted, is useful to provide a readily inserted, readily retained, and readily removable source of continued medication for local and systemic effects Subject to the-property of being capable of passage through the polymeric material, a wide range of medication is suitable for use in this improved device for both local and systemic effects. Suitable drugs are triiodothyronine, isoproterenol, atropine, histamine, nitrogen mustard, vitamin B pyrimethamine, hormonal substances,

i.e., estrogenic substances, progestational substances, an-

drogenic substances, e.g., estradiol, progesterone, androstenedione, testosterone, cortisol, medroxyprogesterone acetate, melengestrol acetate, chlormadinone, and the like. In

forv local and systemic effects in the female mammals.

Likewise, there is nodeleterious action on the sensitive tissue in the area of placement in the vaginal tract. Widely varying types of polymeric material are suitable in providing these compatible, nontoxic and nonabsorbable properties, for exampleorganopolysiloxane of the linear type converted to rubber by heat curing (vulcanization). These linear organopolysiloxanes are known as the conventional type, for example dimethyloplysiloxane, Likewise suitable are those known as the RTV type which are converted to the rubbery stateat room temperature in the presence of a catalyst. U.S.

Pat. No. 3,279,996 describes various conventional silicone rubbers which may or may not contain fillers,sujch assilica, .to

enhance tensile strength and the other physical properties of the cured rubber. This patent also describes commercially available'RTV'silicone rubbers. Other patent literature shows the preparation of conventional silicone rubbers, illustratively U.S. ,Pats. Warwick, No. 2,504,137; Konkle et al., No. 2,890,188; andotherpatents set, forth, in the U.S. Pat. to Long et al., No. 3,279,966. Other suitable nontoxic, nonabsorbable,

compatible, drug-permeable polymeric materials, are, for example, nylon, a polyamide'resin made by polymerization of the hexamethylenediamine salt of adipic acidydacron, a synthetic fiber made by E. I. DuPont deNer'nours and Co.

this connection, both in vivo and invitro methods of determination of passage of the drug by diffusion through the drugpermeable polymeric material are available. See Dziuk, P. J. r and Cook,- B., Passage of Steroids Through Silicone Rubbers, Endocrinology, 78:208, 1966; U.S. Pat. No. 3,279,996; Folkman and Edmonds, Circulation Research 102632, 1962; Folkman and Long, J. Surg. Res. 43:139, 1964; Powers, 1. Parasitology51:53 (April 1965), No. 2 Section 2. An in vitro method of test utilizes polymeric material, e.g., polysiloxane tubing which is loaded with the particular drug and plugged at the ends with polysiloxane cement. After allowing about 48 hours for setting or curing, the filled linlr of tubing is placed in, for example, 50 mlof normal saline in a suitable container and shaken at approximately body temperature for about 24 hours. Spectroscopic analysis of the liquid, for example by the isonicotinic hydrazide method for medroxyprogesterone acetate, shows that the drug is capable of permeating through the silastic into the saline material, in which it can be demonstrated by the in vitro test. For in vivo testing, placement of a suitable size device containing a known amount of medicaments, e.g., rnedroxyprogesterone acetate in a polysiloxane,

of medication in each of the annular devices is that sufficient from teraphthalic acid; and ethylene glycol; teflon, a

tetrafluoroethylene polymer manufactured by E. l. DuPont de Nemoursand Co.; polyurethane elastomer prepared accordfor bringing about the desired physiologic effect, for example, the amount sufficient for controlling fertility. Given in ranges of active ingredients, suitable amounts for individual drugs in digitoxin,

the device are as follows: digitoxin, 5 to 50 mg.; triiodothyronine, l to 10 mg.; isoproterenol, lOO mg. to 2 6m; atropine, 10 to 250 mg.; histamine, 1 to 10 mg.; nitrogen mustard, 50 mg. to 2 Gm.; vitamin B 0.5 to 100 mg; pyrimethamine, 50 mg. to l Gm.; estradiol, 0.5 to 100 mg.; progesterone, 50 mg. to 2 Gm.; androstenedione, 50 mg. to 2 6m; testosterone, 50 mg. to 2 Gm.; cortisol, 100 mg. to 2.5 Gm.; medroxyprogesterone acetate, 50 mg. to 2 Gm.; melengestrol acetate, 50 mg. to 2 Gm.; chlormadinone, 50 mg. to 2 Gm. The amount of any additive medication, for example locally effective antimicrobial agent, is calculated on the basis of the known amounts useful in similar vaginal applications. Other principal active medicaments are, for example, antiulcer and antisecret ory agents, for example 'methscopolamine, 75mg. to 2 Gm.; anticoagulant, for example diphenadione, 75 mg. to l Gm; hypocholesteremic agent, for example 3methyl-5-isoxazole carboxylic acid, 200 mg. to 2 Gm.; appetite clepressant, for example D-amphetamine, l mg. to 2 Gml; tranquilizers and sedatives, thiothixene and haloperidol, 50 mg. to 2 6m; hypoglycemic agent, l[[p-[2- (S-chloro-wanisamidokthyl]phenyl]sulfonyl]-3-cyclohexylurea, 100mg. to 2.5 Gm.; hypotensive agent, mecamylamine, 100 mg. to 1.5 Gm; antibacterial and antimalarial agents, 7- deoxy-7(S)-chlorolincomycin, 2 to 7 0m, N-demethyl lincomycin, 2- to .7-Gm., 4 pentyl-N-'demethyl-7(S)-chlorolincomycin, l to 5.Gm.; antihypertensive agent, for example angiotensin amide, 100 mg. to 2 Gm.; glucocorticoid, for example dexamethasone, 10 to 250 mg.: prostaglandins, for example PGE,, PGE PGA, as antiulcer and antisecretory agents and for inhibition of blood platelet stickiness, 0.5 to 10 mg. The aforesaid amounts are ranges of active ingredients tobe included in the annular device, the exact amount depending upon the age, condition of the patient, and the particular effect desired. These amounts are calculated to provide predetermined daily release dosages as follows: for the cardiac stimulant digitoxin, 0.1 to 0.2 mg.; for the metabolic stimulant triiodothyronine, to 100 mcg.; for the bronchodilator isoproterenol, 5 to 30 mg.; for the antianemia agent vitamin B12, to 300 mcg.; for the antimalarial pyrimethamine, l to 5 mg.;' for the estrogen estradiol, 1 to 500 mcg.; for the progestogen progesterone, 0.1 to 20 mg; for the androgens androstenedione and testosterone, 0.1 to 10 mg.; for the glucocorticoid cortisol, 5 to 50 mg.; for the progestogens medroxyprogesterone acetate, melengestrol acetate, and chlormadinone, 0.01 to 10 mg.; for the methscopolamine, 3 to 20 mg.; for the diphenadione, 3 to 5 mg.; for the 3-methyl-5- isoxazole carboxylic acid, l0 to 30 mg.; for rl-amphetamine, 5 to 30 mg.; for thiothixene, 2 to 30 mg.; for haloperidol, 2 to mg.; for the hypoglycemic cyclohexylurea compound, 5 to 50 mg.; for the mecamylamine, 2 to 10 mg.; for the antibacterial,

antimalarial lincomycin compounds, 250 to 500 mg., 250 to 500 mg. and 125 to 300 mg., respectively; for the angiotensin amide, 0.7 to 30 mg.; for the dexamethasone, 0.2 to 2 mg.; and for the prostaglandins, 1 to 10 mcg.

Especially beneficial progestational substances for use in this invention include, for example, norethynodrel, norethindrone, medroxyprogesterone acetate, chlormadinone acetate,

dimethisterone, and ,ethynodiol diacetate. Useful estrogenic substances for combination with these progestogens include,

for example, ethinyl estradiol and 3-methyl ether of ethinyl esthe reproductive tract, for example synivaginitis, endometriosis. These devices are constructed in such a way that they are retained in the vagina for periods of a day up to several months and can be readily inserted and removed, for example in the case of the human female patient. The device, due to its unique shape and size, does not obstruct the os uteri as do diaphragms. The medication for release as desired can be introduced into hollow cavities in the ring forming a tubular device, or directly introduced into the plastic material itself while the device is being manufactured as by molding. The drug can be the individual drugor mixed with suitable compatible physiologic material, for example in the case of a progestogen an estrogen can be included. Likewise, a locally effective antimicrobial agent, for example an antibiotic such as neomycin, nystatin and polymyxin can be included within the polymeric material. The improved device of this invention possesses numerous advantages over, for example the intrauterine devices, which the uterus rejects in some cases. Moreover, nonprofessional placement of the present inventive device is possible in comparison with the intrauterine devices. Unexpected advantages for the improved device as such are ease of placement, ease of retention, ease of removal, relative freedom of infectious conditions, and ease of dosage over a wide range. As aforesaid, the amount of drug incorporated into the inventive device is that sufficient to bring about the local and/or systemic effect, for examplean effective amount for control of fertility, probably by inhibition of ovulation. The medicated device of the present invention provides more uniform and constant serum levels of drug during the predetermined period of time for which the beneficial physiologic effects are desired. This-is in marked contrast to fluctuations that occur with other treatments, for example oral treatment. In thepractice of this invention, low circulating levels ofmedicament can still be highly effective in target tissues while not accumulating in the nontarget tissues. For example in the case of estradiol, the uterine tissue is the target in contrastto the heart, muscle, liver and like tissues, which are non'target tissues.

Depending upon the anatomy of the particular species. involved, the improved ring device will vary in size, for example in the case of the human from about mm. diameter to about mm. diameter, these dimensions being overall dimensions; the diameter of the actual ring itself will be in the neighborhood of about 5 to 10 mm. In the case where an endless helical spring or flat spring structure is used for additional tensing property, the diameter of this metallic part of the ring will vary with that of the device itself. Overall dimensions of the improved medicated ring for use in other species are approximately as follows: for sheep and swine, 20 to 65 mm.; for dogs, 5 to 50 mm.; for cats, 5 to 30 mm.; for cattle, 50 to mm.; and for horses, 50 to mm. These dimensions are overall dimensions. As will be apparent, the actual diameter of the ring itself varies with the overall size and with the particular species. Suitably the annular devices may incorporate a tab for assistance in removal. The polymeric materials are, as disclosed in the aforesaid Modern Plastics Encyclopedia, those that are suitable for molding in manners known to those familiar with this art. Those polymeric materials, for instance the organopolysiloxanes, which are in a liquid state or paste state, can be directly mixed with the drug, for example melengestrol acetate or medroxyprogesterone acetate, and the semifluid material placed into the mold for compression molding with the addition of a catalyst, for example stannous octoate. In case the device is to contain a spring structure for tension properties, this is usually centered in the semifluid material while it is in the mold and thereafter covered by additional drug-containing polymeric material for the compression molding.

An additional, in vivo, technique for determining the suitability of the polymeric material for use in the preparation of the inventive device is as follows: 150 mg. of medr'oxyprogesterone acetate was well mixed with 615 mg. of polysil oxane elastomer 3H2 382 (Dow Corning Company) to prepare resilient containers approximately 4 cm. long and 0.48 cm. in diameter. Different dosages of the drug are obtained by cutting the required length of the material. The material is sterilized and can be inserted subcutaneously into the scapular region of normally cycling female rats. Daily records of vaginal cytology, which reflect the release'of the medroxyprogesterone acetate, are made for periods of 2 to 6 weeks at dosages of 18.75 .mg. for 6 weeks in four animals, 37.5 mg. for 2 weeks in four animals, and 56.25 mg. for 2 weeks in four animals. Cycling is prevented in the otherwise normally cycling female rats. This shows that the active medicament is released by diffusion through the drugpermeable polymer and exerts its physiological effect via the vaginal tract. in addition to the in vivo data in the rats, it was found by measuring the final content of the medicament in the silastic material that average total releases of 4.4 mg., 5 mg. and 5.2 mg. occurred from elastomeric carrier material of 0,5, 1.0 and 1.5 cm. in size, respectively.

The following examples illustrate the manner and process of making and using the inventive annular device, but are not to be construed as limiting. i it EXAMPLE 1 An annular device was 'prepared of organopolysiloxane elastomer containing 170 mg. of medroxyprogesterone acetate. The ring was placed in accordance with the technique of this invention in the vaginal tract of a monkey and allowed to remain there for 63 days. At the end of this time, the residual content of the medicament in the ring was found by analysis to be l32 mg., showing that a sufficient amount for control of fertility was released from the ring during its retention within the vaginal tract.

EXAMPLE 2 Resilient devices are prepared, each to contain 2 Gm. of medroxyprogesterone acetate, 3 drops of stannous octoate as catalyst, and q.s. silastic elastomer, medical grade 382 (Dow Corning Company).

12.85 Gm. of medroxyprogesterone.acetate are thoroughly mixed into 92.15 Gm. dimetliylpolysiloxane elastomer, medical grade 382 (Dow Corning Company). 21 Gms. of this mixture plus 3 drops of catalyst, stannous octoate, is incorporated into each mold designed to prepare a device of an outside diameter of about 80 mm. The two halves of the mold are tightened down bythe use of wing nuts and the mold is allowed to cure in an oven of 40 to 50 C. for l to 2 hours. Each so prepared ring weighs about 17 Gm. and contains about 2 Gm. of the medroxyprogesterone acetate. Placement of a ring in the vaginal tract of the human female supplies an effective amount of medroxyprogesterone acetate for the control of fer tility by inhibition of ovulation. Measurement of basal body temperature shows that ovulation did not occur during a 4 week test period.

Eimilar rings are prepared with other molds designed to give outside diameters of 70, and 75 mm., respectively. Although these annular ring structures will cure at room temperature in the presence-of the catalyst, for convenience and speed of handling, they are cured at temperatures of from about 40 to about 70 C.

Tensing means are added to the devices prepared as in Examplez by positioning within the first half of the mold an endless helical spring having a diameter of about 8 mm. and weighing approximately 4.8 Gm. The upper half of the mold is then sealed down with the use of the wing nuts and the device compression molded in a like manner at about 45 C.

EXAMPLE 4 Polyurethane rubber-type annular devices are prepared by polymerizing two equivalents of methylene bis isocyanate, one equivalent of 3,000 molecular weight polyether triol and one isocyanate, 1,000 of the trio] and 45 of the butanediol. At the time of mixing, melengestrol acetate to provide 2 Gm. per individual ring is added to the mixture. The mixture of drug and elastomer is then heat cured in the mold at about 100 for 1 hour to provide resilient annular devices for placing in the vaginal tract.

EXAMPLE 5 Likewise, medicated annular devices containing an effective amount of the drug which can permeate through the polymeric substance are prepared from nylon, natural rubber, synthetic rubber, dacron, teflon, and polyethylene and are useful in the same manner inproviding continued sustained medication over desired predetermined periods of times in the vaginal tract of the female mammals.

The manner and process of making and using the invention is not limited to the aforesaid examples, :for the other desirable medicaments as heretofore listed can be incorporated into devices prepared from the various polymeric substances to provide sustained medication over predetermined periods of time. As aforesaid, depending upon the particular species in which the device is to be used, the size of the device will vary to provide close anatomical contact with the vagina] or like tract of the female mammals. The relationship between the daily amount of medication to provide a beneficial physiologic effect and the amount initially placed in the inventive annular device has been set forth for the individual drugs concerned, and within this concept the amount of drug is varied for the particular polymer, depending upon the permeability rate and the amount required for the physiological effect. Devices so prepared are likewise beneficially effective in providing the desired medication via the vagina.

Although an annular shaped device is preferred because of simplicity in manufacture and ease in fitting, insertion and removal, other shapes which will fit anatomically, will stay in place and still allow for ease of insertion and removal can be used, such asoval or elliptical shapes. The device does not have to be in one plane if a closer anatomical fit is desired.

lclaim:

1. A medicated annular device in the form of a resilient individual ring which releases medication for systemic effects during intravaginal use in a female mammal consisting essentially of a medicament-permeable, compatible, nonabsorba ble, resilient, polymeric substance and a systemically effective amount of a diffusible medicament for providing to a said female mammal sustained systemic medication for a predetermined period of time.

2. The resilient individual ring of claim 1 wherein the polymeric substance is a polysiloxane or polyurethane elastomer.

3. The resilient individual ring of claim 2 wherein the polysiloxane is convertible to a rubbery state by heat curing or by room temperature in the presence of a catalyst.

4. The resilient individual ring of claim 2 wherein the polysiloxane is an organopolysiloxane 5. The resilient individual ring of claim 4 wherein the organopolysiloxane is dimethylpolysiloxane.

6. The resilient individual ring of claim 1 which is a tubular ring.

7. The resilient individual ring of claim 1 which contains tension providing means.

8. The resilient individual ring of claim 1 wherein the diffusible medicament is effective for systemic inhibition of fertility of said female mammal.

9. The resilient individual ring of claim 5 wherein the dimethylpolysiloxane is convertible to a rubbery state at room temperature in the presence of a catalyst and the diffusibie medicament is medroxyprogesterone acetate.

10. A method of providing a predetermined amount of systemically effective medicament for a predetermined period of time to a female mammal, which consists essentially of equivalent of I ,d butnnediol. Parts by weight are 250 of the 7 retain-ably positioning within the vaginal tract of a said female 7 mammal for said predetermined period of time a resilient individual ring according to claim 1.

11. A method of providing a predetermined amount of systemically effective medicament for a predetermined period of time to a female human, which consists essentially of retainably positioning within the vaginal tract of a said female human for said predetermined period of time a resilient individual ring according to claim 2.

12. A method of providing a predetermined amount of systemically effective medicament for a predetermined period of time to a female human, which consists essentially of retainably positioning within the vaginal tract of a said female human for said predetermined period of time a resilient individual ting according to claim 3.

13. A method of providing a predetermined amount of systemically effective medicament for a predetermined period of time to a female human, which consists essentially of retainably positioning within the vaginal tract of a said female human for said predetermined-period of time a resilient individual ring according to claim 4.

14. A method of providing a predetermined amount of systemically effective medicament for a predetermined period of time to a female human, which consists essentially of retainably positioning within the vaginal tract of a said female human for said predetermined period of time a resilient individual ring according to claim 5.

15. A method of providing a predetermined amount of systemically effective medicament for a predetermined period of time to a female mammal, which consists essentially of retainably positioning within the vaginal tract of a said female mammal for said predetermined period of time a resilient individual ring according to claim 6.

A method of providing a predetermined amount of systemically effective medicament for a predetermined period of time to a female mammal, which consists essentially of retainably positioning within the vaginal tract of. a said female mammal for said predetermined period of time a resilient individual ring according to claim 7. r

17. A method of providing a predetermined amount of systemically effective fertility-inhibiting medicament for a predetermined period of time to a female mammal, which consists essentially of retainably positioning within the vaginal tract of a said female mammal for said predetermined period of time a resilient individual ring according to claim 8.

18. A method of providing a predetermined amount of medroxyprogesterone acetate for a predetermined period of time to a female human, which consists essentially of retainably positioning within the vaginal tract of a said female human for said predetermined period of time a resilient individual ring according to claim 9.

19. The method of claim 10 wherein the ring is removed at the end of said predetermined period of time.

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Cited By (104)

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US3645258A (en) * 1969-04-08 1972-02-29 Charis Aka Charilaos George Ma Intrauterine device
US3656483A (en) * 1970-01-15 1972-04-18 Biolog Concepts Inc Intrauterine medicator
US3809076A (en) * 1971-06-16 1974-05-07 I Chabon Intrauterine contraceptive device
US3814097A (en) * 1972-02-14 1974-06-04 Ici Ltd Dressing
US3844285A (en) * 1969-08-28 1974-10-29 Commw Scient Ind Res Org Device for administration to ruminants
US3851648A (en) * 1973-10-11 1974-12-03 Mead Johnson & Co Zero-order release device
US3854476A (en) * 1973-04-05 1974-12-17 R Dickinson Intra-vaginal device and method
US3880991A (en) * 1969-03-24 1975-04-29 Brook David E Polymeric article for dispensing drugs
US3887699A (en) * 1969-03-24 1975-06-03 Seymour Yolles Biodegradable polymeric article for dispensing drugs
US3888975A (en) * 1972-12-27 1975-06-10 Alza Corp Erodible intrauterine device
US3892238A (en) * 1971-09-16 1975-07-01 Abbott Lab Drug supporting anchor
US3901232A (en) * 1973-10-26 1975-08-26 Alza Corp Integrated device for administering beneficial drug at programmed rate
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Also Published As

Publication number Publication date Type
ES360946A1 (en) 1970-08-01 application
FR1604934A (en) 1971-05-15 grant
CA985173A (en) 1976-03-09 grant
JPS5125677B1 (en) 1976-08-02 grant
GB1252021A (en) 1971-11-03 application
NL6818655A (en) 1969-07-08 application
CA985173A1 (en) grant
DE1900196A1 (en) 1969-07-31 application
BE726454A (en) 1969-07-03 grant

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