US3656483A - Intrauterine medicator - Google Patents

Intrauterine medicator Download PDF

Info

Publication number
US3656483A
US3656483A US3656483DA US3656483A US 3656483 A US3656483 A US 3656483A US 3656483D A US3656483D A US 3656483DA US 3656483 A US3656483 A US 3656483A
Authority
US
United States
Prior art keywords
device
perforations
container
end
column
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Inventor
Harry Rudel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biological Concepts Inc
Original Assignee
Biological Concepts Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biological Concepts Inc filed Critical Biological Concepts Inc
Priority to US313770A priority Critical
Application granted granted Critical
Publication of US3656483A publication Critical patent/US3656483A/en
Anticipated expiration legal-status Critical
Application status is Expired - Lifetime legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/06Contraceptive devices; Pessaries; Applicators therefor for use by females
    • A61F6/14Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
    • A61F6/142Wirelike structures, e.g. loops, rings, spirals

Abstract

An intrauterine medicator and method for local application of medication to the uterus. The medicator includes a perforated tube containing a supply of medication; apparatus for maintaining medication adjacent the perforations for distribution to the uterine wall, and apparatus resiliently retaining the device in the uterus.

Description

United States Patent Rudel [4 1 Apr. 18, 1972 [54] INTRAUTERINE MEDICATOR 1,605,894 11/ 1926 Human .,128/271 2,623,841 12/1952 Taub ..128/127 X [72] Invent 2,962,023 1l/1960 Chappaz et a1. ..128/260 [73} Assignee: Biological Concepts, Inc., New York, NY, 3,409,721 11/1968 Applezwein ..128/130 Filed: J 1 FOREIGN PATENTS OR APPLICATIONS 1 1 MP 3,137 13,324 7/1894 Great Britain ..128/127 52 us. c1 ..128/264, 128/130 Primary Bummer-Robert Michell 511 1111. C1. ..A61m 31/00 Attorney-Curtis. Morris & Saffvrd [58] Field of Search ..128/264, 130,127, 265, 251,

128/270, 271, 263, 260, 26]; 901/81 ST CT 5 6 R f d An intrauterine medicator and method for local application of l 1 e erences l e medication to the uterus. The medicator includes a perforated UNITED STATES PATENTS tube containing a supply of medication; apparatus for maintaining medication adjacent the perforations for distribution 2,122,579 7/1938 Meckstroth ..128/l30 to h uterine ll, and a paratus'resiliently retaining the 3,442,266 5/1969 Kre1c1 et a1. ...128/130 device i h uterus 3,545,439 12/1970 Duncan ...128/130 1,603,767 10/1926 Harris 128/271 12 Claims, 6 Drawing Figures PATENTEDAPR 1 8 I972 I //l l/ INVENTOR.

Buclel 2%? ATTO rs INTRAUTERINE MEDICATOR The present invention relates to intrauterine medicator devices and in particular to intrauterine carries of medication for locally supplying medication to the uterine walls. One of the embodiments of the invention is directed to an intrauterine carrier of antifertility agents.

In the practice of medicine it has been found desirable to furnish certain'therapeutic and biologically active materials to the uterus by local rather than systemic administration of the drug. For example, certain biologically active materials such as progesterone and progestational compounds, which are known in the prior art as effective antifertility agents, have been administered systemically in the past with resulting undesirable side effects in certain patients. However, it has been found that these side effects can be avoided by locally supplying these agents to the uterine wall.

Specifically, progesterone and progestational compounds when supplied locally to the uterus produce changes in the endometrium which are characteristic of the biological action of the same progestational compounds given systemically. Such changes, characterized as premature maturation of the endometrium, are capable of significant antifertility effects and can be achieved with doses of progestational agents small enough not to inhibit ovulation.

While local administration of natural progesterone hormones has been attempted in the past, success has been achieved only by repeated and frequent applications.

It is an object of this invention to supply antifertility agents and other medication, locally, to the uterine wall. It is another object of the invention continuously to provide such medication over extended periods of time. Another object of the invention is to provide apparatus for retaining a container of medication in the uterus. A still further object of the invention is to provide a method for locally administering biologically active medication to the uterus. It is a further object of the invention to provide a simple and inexpensive intrauterine medicator device.

In accordance with the preferred embodiment of the present invention there is provided an intrauterine medicator having a perforated tube, such as of corrosion-resistant or coated metal, or of plastic, in which a supply of a medication, is enclosed. The drug is suitably in the form of individual pellets and is urged under the force of means, such as a com pressed spring, in the tube to a position adjacent the perforations. The tube is adapted to be inserted in the uterus so that body fluids can leach the medication from the tube through the perforations for local administration to the uterine wall. As the drug dissolves in the area of the perforations, the compressed spring pushes a new supply of the drug adjacent the perforations so that a continuous controlled release of the drug is obtained. The drug utilized in the medicator tube may be any therapeutic or biologically active material which is adapted to local administration; however, in the preferred embodiments an antifertility agent such as progesterone is utilized.

The medicator tube is retained in the uterus by a pair of generally inverted V-shaped springs, each having one leg fixed to the tube. The free leg of each spring extends beyond the tube and resiliently engages the uterine wall to maintain the position of the device in the uterus. In another embodiment the tube may be formed as part of a so-called intrauterine contraceptive device or IUD, such as the well-known Lippes Loop or other such devices. In this manner the tube of the present invention supplements the function of the IUD and is held thereby in position in the uterus.

The construction of the preferred embodiment as well as further objects and advantages thereof will become further ap-' parent from the following specification when considered in conjunction with the accompanying drawings wherein:

FIG. 1 is a perspective view of the intrauterine medicator of the present invention;

FIG. 2 is a plan view of the device illustrated in FIG. 1;

FIG. 3 is a view taken on line 3-3 of FIG. 2;

FIG. 4 is a perspective view of the intrauterine medicator contained within an instrument for insertion of the device into the uterus;

FIG. 5 is a view similar to FIG. 3, of another embodiment of the present invention; and

FIG. 6 is a front view of the medicator of the present invention formed as part of an intrauterine contraceptive device.

Referring now to the drawings, and in particular to FIG. 1, there is shown an intrauterine medicator 10 having spring retaining apparatus 12 which is adapted to maintain the medicator in position in the uterus.

Medicator 10 includes a cylindrical tube 14 having top and bottom ends 16 and 18 respectively. In the preferred embodiment tube 14 has a diameter of about l.5 2.0 millimeters and a length of about 2 centimeters. Ends 16 and 18 are closed by plates 20 and 22 respectively, which serve to retain a column of pellets 24 of a biologically active material, such as an antifertility agent, within tube 14.

The lower portion of tube 14 adjacent end 18 includes a plurality of perforations 26 through which the medicament is leached by body fluids within the uterine cavity. As individual pellets 24 dissolve, a new pellet will be moved into position adjacent perforations 26 by spring 28 to provide continuous release of medication. Spring 28 is a compression spring retained between the top plate 20 of tube 14 and bearing plate 30. Plate 30 is slidable within tube 14 and cooperates with spring 28 to push pellets 24toward perforations 26. In addition, plate 30 prevents mutilation of the uppermost pellet 24 by the end 29 of spring 28.

The number of perforations'26 and the size of pellets 24 may be correlated such that a single pellet will provide suffcient medication for a given period of time. The lowermost pellet 24a dissolves during the course of the desired time period and at the end of this period is weakened sufficiently so that it crumbles under the force of spring 28. Spring 28 then urges the entire column of pellets 24 downwardly towards lower end plate 22 whereby the next pellet, 24b in FIG. 2, is presented adjacent perforations 26 to again furnish the medication to the uterus for the desired time period. It is foreseen, for example, that the perforations 26 and the size and composition of pellets 24 may be correlated to an individual womens menstrual cycle so that a new pellet 24 is presented adjacent perforations 26 at the beginning of each cycle.

Pellets 24, as previously noted, are formed of a biologically active material. Such materials, in the preferred embodiment, include steroid hormones such as progesterone or related synthetic progestational compounds, estrogen, and testosterone, or other antifertility agents such as quinacrine, azauridine, or metallic copper grains. It is also foreseen that tube 14 can also carry therapeutic agents such as antibiotics for intrauterine treatments.

Intrauterine medicator 10 is maintained in position in the uterus by retaining apparatus 12 which includes a pair of inverted generally V-shaped spring members 32, which may be of metal, plastic, or some other resilient material. Each spring 32 has a pair of diverging legs 34 and 36 lying in parallel planes tangent to tube 14. Each leg 34 is fixed to the exterior surface of tube 14, for example, by adhesive, brazing, etc., and extends longitudinally therealong. Legs 36 are formed at an acute angle to legs 34 and diverge from one another to form a large inverted V as seen in FIG. 1.

When inserted in the uterus, the diverging free ends of legs 36 engage the uterine walls to retain the medicator in its proper position. Balls 38 or other similar blunt structure are formed on the free ends of legs 36 to prevent injury to the uterine wall. In addition, by the construction described, the coiled portions of spring members 32 lie in parallel planes, tangent to tube 14 whereby they are relatively fiat against tube 14 and provide a compact, safe assembly. It is also noted that any corrodable or otherwise objectionable metal parts of the medicator i.e., the spring, are suitably coated with a benign material such as Silastic.

In FIG. 4 there is illustrated an applicator 40 containing medicator prior to insertion in the uterus through the vaginal canal. Applicator 40 includes cylindrical tube 42 which receives medicator 10 and maintains spring members 32 in a compressed state during insertion. A plunger member 44 is also provided which is slidable within tube 42 upon actuation of handle 46. Medicator 10 remains in applicator 40 in the condition shown in FIG. 4, during the insertion operation. When the proper uterine position is achieved, plunger 44 is actuated by movement of handle 46 to push medicator 10 through the open top of tube 42 until arms 36 are freed to spring open to their uncompressed state and engage the uterine wall. In this manner medicator 10 is lodged in place and applicator 40 is then withdrawn.

The intrauterine medicator of the present invention may be constructed in a somewhat modified form as shown in FIG. 5. In this embodiment a cylindrical medicator 50, including a tube 52 closed at its opposed ends by plates 54, has a plurality of perforations 56 located intermediate the ends thereof. A column of medication, conveniently in pellet form 55, is retained as in the prior embodiment within tube 52 between a pair of elastic members such as springs 58, which serve to maintain the central portion of the column adjacent perforations 56. Springs 58 act in compression and are contained between end plates 54 and the ends of column 55. Bearing plates 60, similar to plate 30 of the prior embodiment, are provided so that springs 58 do not damage the endmost pellets of medication.

Spring retaining means 62, similar to spring retaining means 12 of the prior embodiment, are provided on the exterior surface of medicator 50 to retain the device in the uterus during use.

The dual spring construction of the embodiment illustrated in FIG. 5 provides a shorter working distance for spring members 58 so that a generally uniform force is applied to the column of medication as it dissolves during use. Thus, variations in the forces applied by springs 58, due to their spring constants and the distance over which they act, are minimized.

While certain preferred embodiments of the intrauterine medicator of the present invention are intended, as disclosed above, to be self-contained units adapted to provide complete antifertility protection, it is foreseen that this medicator may be utilized to supplement presently available intrauterine contraceptive devices, i.e., the well-known IUD.

It is known in the prior art that the presence of foreign objects in the uterus discourages conception, and it has been found that the larger an IUD is, the more effective it is in preventing conception. The employment of such devices, however, is subject to a number of disadvantages, particularly as their size is increased. The more common problems involve discomfort, bleeding, muscular spasms tending to eject the IUD from the uterus, and danger of puncturing the uterine wall during insertion. Each of these problems may be substantially avoided by decreasing the size of the IUD, with a resultant loss, however, in its elfectiveness. It is foreseen that this loss can be compensated by supplementing an IUD with the medicator of the present invention to increase its effectiveness.

In FIG. 6, there is illustrated an intrauterine contraceptive device 70 having an intrauterine medicator 72, similar in construction to the medicator l0 disclosed in FIG. 1. IUD 70 is formed in the general shape of a 7, including a transverse arm 74 having a downwardly concave flexure 76 substantially at its midpoint and a longitudinally extending arm 78 depending from one end 77 of arm 74. Medicator 72 is formed integrally in arm 78 to supplement the contraceptive effects of the device. Both IUD 70 and medicator 72 may be formed of a rigid but flexible physiologically inert material, commonly a plastic such as polyethylene, polypropylene, nylon, Silastic, Dacron,"or the like.

The device is retained in the uterus in part by the lateral pressure exerted by the resilient material of the device around the flexure 76 which tends to engage the ends of transverse arm 74 into the uterine wall. Accordingly, the spring retaining means 12 of the prior embodiments are not required to retain medicator 72 in the uterus, and additionally, the entire device may be decreased in size as medicator 72 will supplement the contraceptive effects of arms 74 and 78.

While only one form of IUD has been illustrated in FIG. 6, and described above, it is foreseen that the medicator of the present invention may be used in combination with other wellknown configurations of IUDs.

The above description of the invention is intended to be illustrative only, and various changes and modifications in the embodiment described may occur to those skilled in the art. These changes may be made without departing from the scope of the invention, and thus it should be apparent that the invention is not limited to the specific embodiments described or illustrated in the drawings.

What is claimed is:

1. A device for the controlled release of a biologically active solid substance in the uterus, said device comprising a supply of said substance and a container therefor, said container being adaptable to containment within the uterine cavity and having perforations in a wall thereof, means within said container for urging said supply of solid substance into the vicinity of said perforations, and resilient retaining means affixed to an external wall of said container for retaining said device within the uterine cavity.

2. A device as defined in claim 1 wherein said solid substance is an antifertility agent.

3. A device as defined in claim 1 wherein said antifertility agent is progesterone.

4. A device as in claim 1 wherein said biologically active substance is in the form of pellets.

5. A device as defined in claim 1 wherein said retaining means comprises, a pair of spring members mounted on said container, each of said spring members having a first end portion fixed to said container and an angularly related second end portion adapted to engage the uterine walls.

6. A device as defined in claim 1 wherein said retaining means comprises a first transverse arm and a second arm coplanar with said first am and dependent therefrom, said second arm including said container.

7. An intrauterine medicator device for the controlled release of biologically active materials, said device comprising a container for said materials adaptable to containment within the uterine cavity and having an elongated generally cylindrical side wall and opposed end wall members, said side wall having a plurality of perforations therein, a column of biologically active material retained within said container and adapted to be released through said perforations into the uterus, means within said container for urging said material towards said perforations and maintaining a supply thereof adjacent said perforations, and resilient retaining means affixed to an external wall of said container for retaining said device within the uterine cavity.

8. A device as defined in claim 7 wherein said perforations are formed in said side wall at locations substantially intermediate said end walls, and said means for urging said material towards said perforations comprises a compression spring positioned within said container at each end thereof for bearing engagement with its associated end wall and the opposed end of said column whereby the central portion of said column is maintained adjacent said perforations during release of said material.

9. A device as defined in claim 7 wherein said perforations are formed in said side wall at one end thereof, and said means for urging said material towards said perforations comprises a compression spring positioned within said container in bearing relation between the other of said end walls and one end of said column to maintain the other end of said column adjacent said perforations and against said one wall during release of said biologically active material.

10. An intrauterine medicator device comprising, in combination, a generally cylindrical tube having closed end portions and formed of an inert material, said tube having a plurality of perforations adjacent one end portion thereof, a column of individual pellets of biologically active material contained within said tube, a compression spring positioned in said tube in bearing relation between the other end portion of 5 said tube and one end of said column to urgesaid column towards said one end and to continuously maintain a portion of said column adjacent said perforations, a pair of spring members mounted on said container, each of said spring members having a first end portion fixed on said container and extending parallel to the longitudinal axis thereof and a second end portion diverging at an acute angle from said first portion adapted to engage the uterine walls to retain said device in the

Claims (12)

1. A device for the controlled release of a biologically active solid substance in the uterus, said device comprising a supply of said substance and a container therefor, said container being adaptable to containment within the uterine cavity and having perforations in a wall thereof, means within said container for urging said supply of solid substance into the vicinity of said perforations, and resilient retaining means affixed to an external wall of said container for retaining said device within the uterine cavity.
2. A device as defined in claim 1 wherein said solid substance is an antifertility agent.
3. A device as defined in claim 1 wherein said antifertility agent is progesterone.
4. A device as in claim 1 wherein said biologically active substance is in the form of pellets.
5. A device as defined in claim 1 wherein said retaining means comprises, a pair of spring members mounted on said container, each of said spring members having a first end portion fixed to said container and an angularly related second end portion adapted to engage the uterine walls.
6. A device as defined in claim 1 wherein said retaining means comprises a first transverse arm and a second arm coplanar with said first arm and dependent therefrom, said second arm including said container.
7. An intrauterine medicator device for the controlled release of biologically active materials, said device comprising a container for said materials adaptablE to containment within the uterine cavity and having an elongated generally cylindrical side wall and opposed end wall members, said side wall having a plurality of perforations therein, a column of biologically active material retained within said container and adapted to be released through said perforations into the uterus, means within said container for urging said material towards said perforations and maintaining a supply thereof adjacent said perforations, and resilient retaining means affixed to an external wall of said container for retaining said device within the uterine cavity.
8. A device as defined in claim 7 wherein said perforations are formed in said side wall at locations substantially intermediate said end walls, and said means for urging said material towards said perforations comprises a compression spring positioned within said container at each end thereof for bearing engagement with its associated end wall and the opposed end of said column whereby the central portion of said column is maintained adjacent said perforations during release of said material.
9. A device as defined in claim 7 wherein said perforations are formed in said side wall at one end thereof, and said means for urging said material towards said perforations comprises a compression spring positioned within said container in bearing relation between the other of said end walls and one end of said column to maintain the other end of said column adjacent said perforations and against said one wall during release of said biologically active material.
10. An intrauterine medicator device comprising, in combination, a generally cylindrical tube having closed end portions and formed of an inert material, said tube having a plurality of perforations adjacent one end portion thereof, a column of individual pellets of biologically active material contained within said tube, a compression spring positioned in said tube in bearing relation between the other end portion of said tube and one end of said column to urge said column towards said one end and to continuously maintain a portion of said column adjacent said perforations, a pair of spring members mounted on said container, each of said spring members having a first end portion fixed on said container and extending parallel to the longitudinal axis thereof and a second end portion diverging at an acute angle from said first portion adapted to engage the uterine walls to retain said device in the uterus, whereby body fluids leach said biologically active material through said perforations for local application to said uterine walls.
11. A device as defined in claim 10 wherein said second end portions of said spring members lie in parallel planes, tangent to said tube and extend in generally opposite directions whereby said spring members form an inverted V-shaped retaining means.
12. A device as defined in claim 11 including, a bearing pad positioned between said compression spring and one end of said column.
US3656483D 1970-01-15 1970-01-15 Intrauterine medicator Expired - Lifetime US3656483A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US313770A true 1970-01-15 1970-01-15

Publications (1)

Publication Number Publication Date
US3656483A true US3656483A (en) 1972-04-18

Family

ID=21704347

Family Applications (1)

Application Number Title Priority Date Filing Date
US3656483D Expired - Lifetime US3656483A (en) 1970-01-15 1970-01-15 Intrauterine medicator

Country Status (4)

Country Link
US (1) US3656483A (en)
DE (1) DE2101533A1 (en)
DK (1) DK126614B (en)
GB (1) GB1333657A (en)

Cited By (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3880991A (en) * 1969-03-24 1975-04-29 Brook David E Polymeric article for dispensing drugs
US3888975A (en) * 1972-12-27 1975-06-10 Alza Corp Erodible intrauterine device
US3911911A (en) * 1969-06-16 1975-10-14 Reese Hospital Michael Anti-fertility device
US3913573A (en) * 1972-10-02 1975-10-21 Morton Gutnick Intrauterine contraceptive devices with plural parallel leg segments
US3996933A (en) * 1972-10-02 1976-12-14 Morton Gutnick Intrauterine contraceptive devices and processes
US4102998A (en) * 1972-10-02 1978-07-25 Morton Gutnick Process for the prevention of venereal disease
WO1982000094A1 (en) * 1980-07-02 1982-01-21 Laby R Controlled release compositions for administration of therapeutic agents to ruminants
US4628924A (en) * 1983-01-20 1986-12-16 Hugo Cimber Intrauterine contraceptive device
US4687480A (en) * 1984-09-14 1987-08-18 Commonwealth Scientific And Industrial Research Organization Controlled release capsule
US4723958A (en) * 1986-05-23 1988-02-09 Merck & Co., Inc. Pulsatile drug delivery system
US4816257A (en) * 1985-09-20 1989-03-28 Research & Education Institute, Harbor-Ucla Medical Center Inc. Method for producing an in vivo environment suitable for human embryo transfer
US4874388A (en) * 1987-06-25 1989-10-17 Alza Corporation Multi-layer delivery system
US4932422A (en) * 1989-06-12 1990-06-12 Ragheb Gamal A Contraceptive device
US4957494A (en) * 1987-06-25 1990-09-18 Alza Corporation Multi-layer delivery system
US5023088A (en) * 1987-06-25 1991-06-11 Alza Corporation Multi-unit delivery system
US5110597A (en) * 1987-06-25 1992-05-05 Alza Corporation Multi-unit delivery system
US5116619A (en) * 1988-08-30 1992-05-26 Lee Roy Morgan Vaginal progesterone tablet
US5494047A (en) * 1994-03-16 1996-02-27 Van Os; Willem A. A. Intrauterine contraceptive device
US5499979A (en) * 1987-06-25 1996-03-19 Alza Corporation Delivery system comprising kinetic forces
US6436069B1 (en) * 1995-03-23 2002-08-20 Advanced Animal Technology Limited Substance delivery device
US20040034357A1 (en) * 1999-08-03 2004-02-19 University Of Massachusetts, A Massachusetts Corporation Controlled release implantable devices
EP1400258A1 (en) * 2002-09-18 2004-03-24 Schering Oy Pharmaceutical composition delivery device and its manufacturing process
US6962579B2 (en) * 1995-03-23 2005-11-08 Advanced Animal Technology Limited Substance delivery device
FR2903879A1 (en) * 2006-07-21 2008-01-25 Ancova Sa intrauterine system recuperable
WO2009060077A2 (en) 2007-11-07 2009-05-14 N.V. Organon Intrauterine deposit
US7601165B2 (en) 2006-09-29 2009-10-13 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable suture loop
US7608092B1 (en) 2004-02-20 2009-10-27 Biomet Sports Medicince, LLC Method and apparatus for performing meniscus repair
US20100168563A1 (en) * 2006-02-16 2010-07-01 David Braver device and method for the prolonged delivery of an active agent to a body cavity
US7749250B2 (en) 2006-02-03 2010-07-06 Biomet Sports Medicine, Llc Soft tissue repair assembly and associated method
US20100280464A1 (en) * 2009-05-04 2010-11-04 N.V. Organon Intrauterine system
US7857830B2 (en) 2006-02-03 2010-12-28 Biomet Sports Medicine, Llc Soft tissue repair and conduit device
US7905903B2 (en) 2006-02-03 2011-03-15 Biomet Sports Medicine, Llc Method for tissue fixation
US7905904B2 (en) 2006-02-03 2011-03-15 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US7909851B2 (en) 2006-02-03 2011-03-22 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US7959650B2 (en) 2006-09-29 2011-06-14 Biomet Sports Medicine, Llc Adjustable knotless loops
US20110275885A1 (en) * 2008-02-20 2011-11-10 Anecova Sa Recoverable intra-uterine system
US8088130B2 (en) 2006-02-03 2012-01-03 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8118836B2 (en) 2004-11-05 2012-02-21 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8128658B2 (en) 2004-11-05 2012-03-06 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
US8137382B2 (en) 2004-11-05 2012-03-20 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US8251998B2 (en) 2006-08-16 2012-08-28 Biomet Sports Medicine, Llc Chondral defect repair
US8298262B2 (en) 2006-02-03 2012-10-30 Biomet Sports Medicine, Llc Method for tissue fixation
US8303604B2 (en) 2004-11-05 2012-11-06 Biomet Sports Medicine, Llc Soft tissue repair device and method
US8317825B2 (en) 2004-11-09 2012-11-27 Biomet Sports Medicine, Llc Soft tissue conduit device and method
US8343227B2 (en) 2009-05-28 2013-01-01 Biomet Manufacturing Corp. Knee prosthesis assembly with ligament link
US8361113B2 (en) 2006-02-03 2013-01-29 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8500818B2 (en) 2006-09-29 2013-08-06 Biomet Manufacturing, Llc Knee prosthesis assembly with ligament link
US8506597B2 (en) 2011-10-25 2013-08-13 Biomet Sports Medicine, Llc Method and apparatus for interosseous membrane reconstruction
AU2012258311B2 (en) * 2007-11-07 2013-09-05 Merck Sharp & Dohme B.V. Intrauterine deposit
US8562647B2 (en) 2006-09-29 2013-10-22 Biomet Sports Medicine, Llc Method and apparatus for securing soft tissue to bone
US8562645B2 (en) 2006-09-29 2013-10-22 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US8574235B2 (en) 2006-02-03 2013-11-05 Biomet Sports Medicine, Llc Method for trochanteric reattachment
US8597327B2 (en) 2006-02-03 2013-12-03 Biomet Manufacturing, Llc Method and apparatus for sternal closure
US8652172B2 (en) 2006-02-03 2014-02-18 Biomet Sports Medicine, Llc Flexible anchors for tissue fixation
US8652171B2 (en) 2006-02-03 2014-02-18 Biomet Sports Medicine, Llc Method and apparatus for soft tissue fixation
US8672969B2 (en) 2006-09-29 2014-03-18 Biomet Sports Medicine, Llc Fracture fixation device
US8771352B2 (en) 2011-05-17 2014-07-08 Biomet Sports Medicine, Llc Method and apparatus for tibial fixation of an ACL graft
US8801783B2 (en) 2006-09-29 2014-08-12 Biomet Sports Medicine, Llc Prosthetic ligament system for knee joint
US8936621B2 (en) 2006-02-03 2015-01-20 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US8968364B2 (en) 2006-02-03 2015-03-03 Biomet Sports Medicine, Llc Method and apparatus for fixation of an ACL graft
US8998949B2 (en) 2004-11-09 2015-04-07 Biomet Sports Medicine, Llc Soft tissue conduit device
US9017381B2 (en) 2007-04-10 2015-04-28 Biomet Sports Medicine, Llc Adjustable knotless loops
US9078644B2 (en) 2006-09-29 2015-07-14 Biomet Sports Medicine, Llc Fracture fixation device
US9149267B2 (en) 2006-02-03 2015-10-06 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US9259217B2 (en) 2012-01-03 2016-02-16 Biomet Manufacturing, Llc Suture Button
US9271713B2 (en) 2006-02-03 2016-03-01 Biomet Sports Medicine, Llc Method and apparatus for tensioning a suture
US9314241B2 (en) 2011-11-10 2016-04-19 Biomet Sports Medicine, Llc Apparatus for coupling soft tissue to a bone
US9357991B2 (en) 2011-11-03 2016-06-07 Biomet Sports Medicine, Llc Method and apparatus for stitching tendons
US9370350B2 (en) 2011-11-10 2016-06-21 Biomet Sports Medicine, Llc Apparatus for coupling soft tissue to a bone
US9381013B2 (en) 2011-11-10 2016-07-05 Biomet Sports Medicine, Llc Method for coupling soft tissue to a bone
US9538998B2 (en) 2006-02-03 2017-01-10 Biomet Sports Medicine, Llc Method and apparatus for fracture fixation
US9615822B2 (en) 2014-05-30 2017-04-11 Biomet Sports Medicine, Llc Insertion tools and method for soft anchor
US9668912B2 (en) 2008-09-17 2017-06-06 Bayer Oy Inserter
US9700291B2 (en) 2014-06-03 2017-07-11 Biomet Sports Medicine, Llc Capsule retractor
US9757119B2 (en) 2013-03-08 2017-09-12 Biomet Sports Medicine, Llc Visual aid for identifying suture limbs arthroscopically
US9918826B2 (en) 2006-09-29 2018-03-20 Biomet Sports Medicine, Llc Scaffold for spring ligament repair
US9918827B2 (en) 2013-03-14 2018-03-20 Biomet Sports Medicine, Llc Scaffold for spring ligament repair
US9955980B2 (en) 2015-02-24 2018-05-01 Biomet Sports Medicine, Llc Anatomic soft tissue repair
US10039543B2 (en) 2014-08-22 2018-08-07 Biomet Sports Medicine, Llc Non-sliding soft anchor
US10092288B2 (en) 2006-02-03 2018-10-09 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US10136886B2 (en) 2013-12-20 2018-11-27 Biomet Sports Medicine, Llc Knotless soft tissue devices and techniques
US10251637B2 (en) 2015-10-06 2019-04-09 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19606355A1 (en) * 1996-02-12 1997-08-14 Schering Ag Contraceptive delivery systems with antiviral and / or antibacterial effect

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB189413324A (en) * 1894-07-10 1895-05-24 Frederick William Golby A Pessary with Disinfecting Receptacle.
US1603767A (en) * 1926-03-12 1926-10-19 Harris John Means for treating organs of the body
US1605894A (en) * 1926-11-02 homan
US2122579A (en) * 1934-06-13 1938-07-05 Louis W Meckstroth Intra-uterine device
US2623841A (en) * 1950-11-21 1952-12-30 Schmid Inc Julius Spermicidal compositions
US2962023A (en) * 1955-10-28 1960-11-29 Chappaz Gaston Medicator
US3409721A (en) * 1967-09-15 1968-11-05 Neomed Lab Inc Oral dosage system effective to control the reproduction cycle
US3442266A (en) * 1966-02-11 1969-05-06 Vyzk Ustav Pletarsky Intra-uterine contraceptive device
US3545439A (en) * 1968-01-04 1970-12-08 Upjohn Co Medicated devices and methods

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1605894A (en) * 1926-11-02 homan
GB189413324A (en) * 1894-07-10 1895-05-24 Frederick William Golby A Pessary with Disinfecting Receptacle.
US1603767A (en) * 1926-03-12 1926-10-19 Harris John Means for treating organs of the body
US2122579A (en) * 1934-06-13 1938-07-05 Louis W Meckstroth Intra-uterine device
US2623841A (en) * 1950-11-21 1952-12-30 Schmid Inc Julius Spermicidal compositions
US2962023A (en) * 1955-10-28 1960-11-29 Chappaz Gaston Medicator
US3442266A (en) * 1966-02-11 1969-05-06 Vyzk Ustav Pletarsky Intra-uterine contraceptive device
US3409721A (en) * 1967-09-15 1968-11-05 Neomed Lab Inc Oral dosage system effective to control the reproduction cycle
US3545439A (en) * 1968-01-04 1970-12-08 Upjohn Co Medicated devices and methods

Cited By (161)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3880991A (en) * 1969-03-24 1975-04-29 Brook David E Polymeric article for dispensing drugs
US3911911A (en) * 1969-06-16 1975-10-14 Reese Hospital Michael Anti-fertility device
US3913573A (en) * 1972-10-02 1975-10-21 Morton Gutnick Intrauterine contraceptive devices with plural parallel leg segments
US4102998A (en) * 1972-10-02 1978-07-25 Morton Gutnick Process for the prevention of venereal disease
US3996933A (en) * 1972-10-02 1976-12-14 Morton Gutnick Intrauterine contraceptive devices and processes
US3888975A (en) * 1972-12-27 1975-06-10 Alza Corp Erodible intrauterine device
WO1982000094A1 (en) * 1980-07-02 1982-01-21 Laby R Controlled release compositions for administration of therapeutic agents to ruminants
US4671789A (en) * 1980-07-02 1987-06-09 Commonwealth Scientific And Industrial Research Organization Controlled release compositions for administration of therapeutic agents to ruminants
US4628924A (en) * 1983-01-20 1986-12-16 Hugo Cimber Intrauterine contraceptive device
US4687480A (en) * 1984-09-14 1987-08-18 Commonwealth Scientific And Industrial Research Organization Controlled release capsule
US4816257A (en) * 1985-09-20 1989-03-28 Research & Education Institute, Harbor-Ucla Medical Center Inc. Method for producing an in vivo environment suitable for human embryo transfer
US4723958A (en) * 1986-05-23 1988-02-09 Merck & Co., Inc. Pulsatile drug delivery system
US4874388A (en) * 1987-06-25 1989-10-17 Alza Corporation Multi-layer delivery system
US5499979A (en) * 1987-06-25 1996-03-19 Alza Corporation Delivery system comprising kinetic forces
US4957494A (en) * 1987-06-25 1990-09-18 Alza Corporation Multi-layer delivery system
US5023088A (en) * 1987-06-25 1991-06-11 Alza Corporation Multi-unit delivery system
US5110597A (en) * 1987-06-25 1992-05-05 Alza Corporation Multi-unit delivery system
US5116619A (en) * 1988-08-30 1992-05-26 Lee Roy Morgan Vaginal progesterone tablet
US4932422A (en) * 1989-06-12 1990-06-12 Ragheb Gamal A Contraceptive device
US5494047A (en) * 1994-03-16 1996-02-27 Van Os; Willem A. A. Intrauterine contraceptive device
US6962579B2 (en) * 1995-03-23 2005-11-08 Advanced Animal Technology Limited Substance delivery device
US6436069B1 (en) * 1995-03-23 2002-08-20 Advanced Animal Technology Limited Substance delivery device
US20040034357A1 (en) * 1999-08-03 2004-02-19 University Of Massachusetts, A Massachusetts Corporation Controlled release implantable devices
AU2003258752B2 (en) * 2002-09-18 2008-03-06 Bayer Schering Pharma Oy A delivery system and a manufacturing process of a delivery system
US20060016451A1 (en) * 2002-09-18 2006-01-26 Esa Hallinen Delivery sysem and a manufacturing process of a delivery system
US7252839B2 (en) 2002-09-18 2007-08-07 Schering Oy Delivery system and a manufacturing process of a delivery system
EP1400258A1 (en) * 2002-09-18 2004-03-24 Schering Oy Pharmaceutical composition delivery device and its manufacturing process
US7608092B1 (en) 2004-02-20 2009-10-27 Biomet Sports Medicince, LLC Method and apparatus for performing meniscus repair
US8221454B2 (en) 2004-02-20 2012-07-17 Biomet Sports Medicine, Llc Apparatus for performing meniscus repair
US8118836B2 (en) 2004-11-05 2012-02-21 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US9504460B2 (en) 2004-11-05 2016-11-29 Biomet Sports Medicine, LLC. Soft tissue repair device and method
US8551140B2 (en) 2004-11-05 2013-10-08 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
US8128658B2 (en) 2004-11-05 2012-03-06 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
US8303604B2 (en) 2004-11-05 2012-11-06 Biomet Sports Medicine, Llc Soft tissue repair device and method
US8840645B2 (en) 2004-11-05 2014-09-23 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US9572655B2 (en) 2004-11-05 2017-02-21 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US9801708B2 (en) 2004-11-05 2017-10-31 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8137382B2 (en) 2004-11-05 2012-03-20 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US8317825B2 (en) 2004-11-09 2012-11-27 Biomet Sports Medicine, Llc Soft tissue conduit device and method
US8998949B2 (en) 2004-11-09 2015-04-07 Biomet Sports Medicine, Llc Soft tissue conduit device
US9622736B2 (en) 2006-02-03 2017-04-18 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US7905903B2 (en) 2006-02-03 2011-03-15 Biomet Sports Medicine, Llc Method for tissue fixation
US7905904B2 (en) 2006-02-03 2011-03-15 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US7909851B2 (en) 2006-02-03 2011-03-22 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US9642661B2 (en) 2006-02-03 2017-05-09 Biomet Sports Medicine, Llc Method and Apparatus for Sternal Closure
US9603591B2 (en) 2006-02-03 2017-03-28 Biomet Sports Medicine, Llc Flexible anchors for tissue fixation
US8088130B2 (en) 2006-02-03 2012-01-03 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US9763656B2 (en) 2006-02-03 2017-09-19 Biomet Sports Medicine, Llc Method and apparatus for soft tissue fixation
US7857830B2 (en) 2006-02-03 2010-12-28 Biomet Sports Medicine, Llc Soft tissue repair and conduit device
US9801620B2 (en) 2006-02-03 2017-10-31 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
US7749250B2 (en) 2006-02-03 2010-07-06 Biomet Sports Medicine, Llc Soft tissue repair assembly and associated method
US9993241B2 (en) 2006-02-03 2018-06-12 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US9561025B2 (en) 2006-02-03 2017-02-07 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US9538998B2 (en) 2006-02-03 2017-01-10 Biomet Sports Medicine, Llc Method and apparatus for fracture fixation
US8273106B2 (en) 2006-02-03 2012-09-25 Biomet Sports Medicine, Llc Soft tissue repair and conduit device
US9532777B2 (en) 2006-02-03 2017-01-03 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8292921B2 (en) 2006-02-03 2012-10-23 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US9510819B2 (en) 2006-02-03 2016-12-06 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US8298262B2 (en) 2006-02-03 2012-10-30 Biomet Sports Medicine, Llc Method for tissue fixation
US10004489B2 (en) 2006-02-03 2018-06-26 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US10004588B2 (en) 2006-02-03 2018-06-26 Biomet Sports Medicine, Llc Method and apparatus for fixation of an ACL graft
US9510821B2 (en) 2006-02-03 2016-12-06 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US8337525B2 (en) 2006-02-03 2012-12-25 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US10022118B2 (en) 2006-02-03 2018-07-17 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8361113B2 (en) 2006-02-03 2013-01-29 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US9498204B2 (en) 2006-02-03 2016-11-22 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US8409253B2 (en) 2006-02-03 2013-04-02 Biomet Sports Medicine, Llc Soft tissue repair assembly and associated method
US9492158B2 (en) 2006-02-03 2016-11-15 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US9468433B2 (en) 2006-02-03 2016-10-18 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US9414833B2 (en) 2006-02-03 2016-08-16 Biomet Sports Medicine, Llc Soft tissue repair assembly and associated method
US10092288B2 (en) 2006-02-03 2018-10-09 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US9402621B2 (en) 2006-02-03 2016-08-02 Biomet Sports Medicine, LLC. Method for tissue fixation
US9271713B2 (en) 2006-02-03 2016-03-01 Biomet Sports Medicine, Llc Method and apparatus for tensioning a suture
US9173651B2 (en) 2006-02-03 2015-11-03 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US8574235B2 (en) 2006-02-03 2013-11-05 Biomet Sports Medicine, Llc Method for trochanteric reattachment
US8597327B2 (en) 2006-02-03 2013-12-03 Biomet Manufacturing, Llc Method and apparatus for sternal closure
US8608777B2 (en) 2006-02-03 2013-12-17 Biomet Sports Medicine Method and apparatus for coupling soft tissue to a bone
US9149267B2 (en) 2006-02-03 2015-10-06 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8632569B2 (en) 2006-02-03 2014-01-21 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US8652172B2 (en) 2006-02-03 2014-02-18 Biomet Sports Medicine, Llc Flexible anchors for tissue fixation
US10098629B2 (en) 2006-02-03 2018-10-16 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US9005287B2 (en) 2006-02-03 2015-04-14 Biomet Sports Medicine, Llc Method for bone reattachment
US10154837B2 (en) 2006-02-03 2018-12-18 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8968364B2 (en) 2006-02-03 2015-03-03 Biomet Sports Medicine, Llc Method and apparatus for fixation of an ACL graft
US8936621B2 (en) 2006-02-03 2015-01-20 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US8721684B2 (en) 2006-02-03 2014-05-13 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US8932331B2 (en) 2006-02-03 2015-01-13 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
US8771316B2 (en) 2006-02-03 2014-07-08 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US8652171B2 (en) 2006-02-03 2014-02-18 Biomet Sports Medicine, Llc Method and apparatus for soft tissue fixation
US20100168563A1 (en) * 2006-02-16 2010-07-01 David Braver device and method for the prolonged delivery of an active agent to a body cavity
FR2903879A1 (en) * 2006-07-21 2008-01-25 Ancova Sa intrauterine system recuperable
WO2008012685A3 (en) * 2006-07-21 2008-04-03 Anecova Sa Recoverable intra-uterine system
US8333688B2 (en) 2006-07-21 2012-12-18 Anecova Sa Recoverable intra-uterine system
US20090299129A1 (en) * 2006-07-21 2009-12-03 Anecova Sa Recoverable intra-uterine system
US8777956B2 (en) 2006-08-16 2014-07-15 Biomet Sports Medicine, Llc Chondral defect repair
US8251998B2 (en) 2006-08-16 2012-08-28 Biomet Sports Medicine, Llc Chondral defect repair
US9414925B2 (en) 2006-09-29 2016-08-16 Biomet Manufacturing, Llc Method of implanting a knee prosthesis assembly with a ligament link
US8672969B2 (en) 2006-09-29 2014-03-18 Biomet Sports Medicine, Llc Fracture fixation device
US8672968B2 (en) 2006-09-29 2014-03-18 Biomet Sports Medicine, Llc Method for implanting soft tissue
US10004493B2 (en) 2006-09-29 2018-06-26 Biomet Sports Medicine, Llc Method for implanting soft tissue
US9918826B2 (en) 2006-09-29 2018-03-20 Biomet Sports Medicine, Llc Scaffold for spring ligament repair
US9833230B2 (en) 2006-09-29 2017-12-05 Biomet Sports Medicine, Llc Fracture fixation device
US9078644B2 (en) 2006-09-29 2015-07-14 Biomet Sports Medicine, Llc Fracture fixation device
US9788876B2 (en) 2006-09-29 2017-10-17 Biomet Sports Medicine, Llc Fracture fixation device
US9724090B2 (en) 2006-09-29 2017-08-08 Biomet Manufacturing, Llc Method and apparatus for attaching soft tissue to bone
US9681940B2 (en) 2006-09-29 2017-06-20 Biomet Sports Medicine, Llc Ligament system for knee joint
US7959650B2 (en) 2006-09-29 2011-06-14 Biomet Sports Medicine, Llc Adjustable knotless loops
US8231654B2 (en) 2006-09-29 2012-07-31 Biomet Sports Medicine, Llc Adjustable knotless loops
US8562645B2 (en) 2006-09-29 2013-10-22 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US9539003B2 (en) 2006-09-29 2017-01-10 Biomet Sports Medicine, LLC. Method and apparatus for forming a self-locking adjustable loop
US7658751B2 (en) 2006-09-29 2010-02-09 Biomet Sports Medicine, Llc Method for implanting soft tissue
US8801783B2 (en) 2006-09-29 2014-08-12 Biomet Sports Medicine, Llc Prosthetic ligament system for knee joint
US7601165B2 (en) 2006-09-29 2009-10-13 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable suture loop
US8500818B2 (en) 2006-09-29 2013-08-06 Biomet Manufacturing, Llc Knee prosthesis assembly with ligament link
US8562647B2 (en) 2006-09-29 2013-10-22 Biomet Sports Medicine, Llc Method and apparatus for securing soft tissue to bone
US9486211B2 (en) 2006-09-29 2016-11-08 Biomet Sports Medicine, Llc Method for implanting soft tissue
US9017381B2 (en) 2007-04-10 2015-04-28 Biomet Sports Medicine, Llc Adjustable knotless loops
US9861351B2 (en) 2007-04-10 2018-01-09 Biomet Sports Medicine, Llc Adjustable knotless loops
EP2942040A1 (en) 2007-11-07 2015-11-11 Merck Sharp & Dohme B.V. Intrauterine deposit
TWI457115B (en) * 2007-11-07 2014-10-21 Merck Sharp & Dohme Intrauterine deposit
CN101848689B (en) 2007-11-07 2014-03-12 默沙东有限责任公司 Intrauterine deposits
AU2012258311B2 (en) * 2007-11-07 2013-09-05 Merck Sharp & Dohme B.V. Intrauterine deposit
AU2008324109B2 (en) * 2007-11-07 2013-02-07 Merck Sharp & Dohme B.V. Intrauterine deposit
WO2009060077A2 (en) 2007-11-07 2009-05-14 N.V. Organon Intrauterine deposit
RU2503431C2 (en) * 2007-11-07 2014-01-10 Мерк Шарт и Доум Б.В. Intrauterine carrier
US20110017219A1 (en) * 2007-11-07 2011-01-27 Wouter De Graaff Intrauterine deposit
US8291910B2 (en) * 2007-11-07 2012-10-23 Msd Oss B.V. Intrauterine deposit
JP2011502604A (en) * 2007-11-07 2011-01-27 ナームローゼ・フエンノートチヤツプ・オルガノン Intrauterine deposit
US20110275885A1 (en) * 2008-02-20 2011-11-10 Anecova Sa Recoverable intra-uterine system
US9668912B2 (en) 2008-09-17 2017-06-06 Bayer Oy Inserter
WO2010128004A1 (en) * 2009-05-04 2010-11-11 N.V. Organon Intrauterine system for use in medical treatment
CN102438562A (en) * 2009-05-04 2012-05-02 奥根农股份公司 Intrauterine system for use in medical treatment
AU2010244494B2 (en) * 2009-05-04 2014-03-06 Merck Sharp & Dohme B.V. Intrauterine system for use in medical treatment
US8568374B2 (en) * 2009-05-04 2013-10-29 Merck Sharp & Dohme B.V. Intrauterine system
JP2012525861A (en) * 2009-05-04 2012-10-25 エム・エス・ディー・オス・ベー・フェー Medical intrauterine system
RU2529477C2 (en) * 2009-05-04 2014-09-27 Мерк Шарп и Доум Б.В. Intrauterine system for therapeutic application
US20140296833A1 (en) * 2009-05-04 2014-10-02 Merck Sharp & Dohme B.V. Intrauterine system for use in medical treatment
CN102438562B (en) * 2009-05-04 2014-11-26 默沙东有限责任公司 Intrauterine system for use in medical treatment
US20100280464A1 (en) * 2009-05-04 2010-11-04 N.V. Organon Intrauterine system
US8900314B2 (en) 2009-05-28 2014-12-02 Biomet Manufacturing, Llc Method of implanting a prosthetic knee joint assembly
US10149767B2 (en) 2009-05-28 2018-12-11 Biomet Manufacturing, Llc Method of implanting knee prosthesis assembly with ligament link
US8343227B2 (en) 2009-05-28 2013-01-01 Biomet Manufacturing Corp. Knee prosthesis assembly with ligament link
US8771352B2 (en) 2011-05-17 2014-07-08 Biomet Sports Medicine, Llc Method and apparatus for tibial fixation of an ACL graft
US9216078B2 (en) 2011-05-17 2015-12-22 Biomet Sports Medicine, Llc Method and apparatus for tibial fixation of an ACL graft
US9445827B2 (en) 2011-10-25 2016-09-20 Biomet Sports Medicine, Llc Method and apparatus for intraosseous membrane reconstruction
US8506597B2 (en) 2011-10-25 2013-08-13 Biomet Sports Medicine, Llc Method and apparatus for interosseous membrane reconstruction
US9357991B2 (en) 2011-11-03 2016-06-07 Biomet Sports Medicine, Llc Method and apparatus for stitching tendons
US9357992B2 (en) 2011-11-10 2016-06-07 Biomet Sports Medicine, Llc Method for coupling soft tissue to a bone
US9381013B2 (en) 2011-11-10 2016-07-05 Biomet Sports Medicine, Llc Method for coupling soft tissue to a bone
US9370350B2 (en) 2011-11-10 2016-06-21 Biomet Sports Medicine, Llc Apparatus for coupling soft tissue to a bone
US9314241B2 (en) 2011-11-10 2016-04-19 Biomet Sports Medicine, Llc Apparatus for coupling soft tissue to a bone
US9259217B2 (en) 2012-01-03 2016-02-16 Biomet Manufacturing, Llc Suture Button
US9433407B2 (en) 2012-01-03 2016-09-06 Biomet Manufacturing, Llc Method of implanting a bone fixation assembly
US9757119B2 (en) 2013-03-08 2017-09-12 Biomet Sports Medicine, Llc Visual aid for identifying suture limbs arthroscopically
US9918827B2 (en) 2013-03-14 2018-03-20 Biomet Sports Medicine, Llc Scaffold for spring ligament repair
US10136886B2 (en) 2013-12-20 2018-11-27 Biomet Sports Medicine, Llc Knotless soft tissue devices and techniques
US9615822B2 (en) 2014-05-30 2017-04-11 Biomet Sports Medicine, Llc Insertion tools and method for soft anchor
US9700291B2 (en) 2014-06-03 2017-07-11 Biomet Sports Medicine, Llc Capsule retractor
US10039543B2 (en) 2014-08-22 2018-08-07 Biomet Sports Medicine, Llc Non-sliding soft anchor
US9955980B2 (en) 2015-02-24 2018-05-01 Biomet Sports Medicine, Llc Anatomic soft tissue repair
US10251637B2 (en) 2015-10-06 2019-04-09 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods

Also Published As

Publication number Publication date
DE2101533A1 (en) 1971-09-16
GB1333657A (en) 1973-10-10
DK126614B (en) 1973-08-06

Similar Documents

Publication Publication Date Title
US3444858A (en) Method and means for administering drugs
US3598115A (en) Intra-uterine contraceptive device
US3405711A (en) Intrauterine contraceptive device
US4252787A (en) Anti-fertility composition and method
US4424054A (en) Fluid-expansible contraceptive tampon and applicator
JP4750782B2 (en) Method and apparatus for occluding a conduit
US3948259A (en) Dispensing instrument
US3760805A (en) Osmotic dispenser with collapsible supply container
Doyle et al. Preliminary studies on the effect of hormone-releasing intrauterine devices
US3822702A (en) Dispensing method and apparatus
EP1320336B1 (en) A vaginal pessary
EP0673629B1 (en) Intrauterine contraceptive device
EP0577891B1 (en) Retrievable pessary
US5002540A (en) Intravaginal device and method for delivering a medicament
Hinds et al. Does gender or the menstrual cycle affect colonic transit?
CN1193718C (en) Intra-vaginal device for pigs and using method thereof
US3563235A (en) Intrauterine contraceptive method
US3200815A (en) Coil spring intra-uterine contraceptive device and method of using
US4308867A (en) Two-member medicated device for rate-controlled administration of lipophilic pharmaceuticals
USRE29207E (en) Dispensing method and apparatus
US3918452A (en) Tampons impregnated with contraceptive compositions
US4579110A (en) Tubular pessary as a contraceptive means
Stys et al. Changes in cervical compliance at parturition independent of uterine activity
Mascarenhas Insertion and removal of Implanon®
Zipper et al. Quinacrine hydrochloride pellets: preliminary data on a nonsurgical method of female sterilization