US3533406A - Intrauterine contraceptive device - Google Patents

Intrauterine contraceptive device Download PDF

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US3533406A
US3533406A US3533406DA US3533406A US 3533406 A US3533406 A US 3533406A US 3533406D A US3533406D A US 3533406DA US 3533406 A US3533406 A US 3533406A
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intrauterine
device
present invention
mm
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Howard J Tatum
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Population Council Inc
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Population Council Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/06Contraceptive devices; Pessaries; Applicators therefor for use by females
    • A61F6/14Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
    • A61F6/142Wirelike structures, e.g. loops, rings, spirals
    • A61F6/144Wirelike structures, e.g. loops, rings, spirals with T-configuration

Description

United States Patent Inventor Howard J. Tatum New York, New York Appl. No. 760,609 Filed Sept. 18, 1968 Patented Oct. 13, 1970 Assignee The Population Council New York, New York a corporation of New York INTRAUTERINE CONTRACEPTIVE DEVICE 2 Claims, 6 Drawing Figs.

US. Cl 128/130, 128/267 Int. Cl A6lf5/46 [50] Field ofSearch 128/127, I28, 129, 130, 131,260, 267

[56] References Cited UNITED STATES PATENTS 3.454004 7/l969 Leininger et al 128/130 Primary Examiner-Adele M. Eager Atlorney-Brumbaugh, Graves, Donohue and Raymond ABSTRACT: An intrauterine contraceptive device is disclosed which has a characteristic T" shape. The length of the crossbar of the T is approximately equal to the lateral dimension of the fundus of the uterus, and the length of the depending leg of the T" is adapted to extend down toward the cervical 0s.

Patented Oct. 13, 1970 J. TA

his ATTORNEYS INTRAUTERINE CONTRACEPTIVE DEVICE This invention relates to an improved contraceptive device and method. I

During recent past years due to world population pressures, a vast amount of research has been undertaken directed to developing improved contraceptive methods. One such method which has gained wide favor because of its high effectiveness is to employ certain hormones known to modify the body endocrinology and suppress ovulation. These hormones, popularly administered as birth control pills, if used regularly, prove to be highly effective and reliable for controlling conception. Nevertheless, they are not without difficulties when used in large-scale birth control programs in developed and developing countries, not only because they are relatively expensive, but also because considerable reliance has to be placed upon the patient to take the pills in accordance with the prescribed regimen.

In view of these disadvantages of conventional birth control pills, the use of intrauterine contraceptive devices has achieved considerable popularity. Such devices may be inserted inexpensively in patients in large-scale programs, and, moreover, do not require reliance upon apatients willingness or ability to follow a particular regimen of treatment. Despite these advantages of the intrauterine contraceptive devices which are already available and being manufactured commercially, it has been found that they are not as effective as the socalled conventional birth control pills, provided the latter are used within the prescribed regimen. Accordingly, considerable effort has been directed toward improving the efficacy of intrauterine contraceptive devices.

A recurrent problem in the use of most intrauterine contraceptive devices is that of involuntary expulsion. Because intrauterine devices are conventionally manufactured to fill' the uterine cavity, these devices inherently apply some anterior-posterior and bilateral pressure to the muscle of the uterus. As a consequence, there is an involuntary reaction of these muscles tending to expel the inserted device.

In accordance with the present invention, it has been discovered that effective contraception may be obtained using intrauterine devices notwithstanding that the device does not fill" the uterine cavity. There is provided by this invention a novel intrauterine contraceptive device having the shape of a T". The top crossbar of the T is normally in the order of from 30 to 38 mm. in length, corresponding generally to the width of the fundal portion of the endometrial cavity. The length of the depending leg of the T" is from 35 to 40 mm., so that it is adapted to extend toward the cervical os when the the crossbar of the T" lies at the fundus of the uterus. The diameter of the T" and crossbar members is in the order of from 2 to 4 mm. The device may be prepared from any pharmaceutically acceptable material, preferably inert plastic such as polyethylene or polypropylene, nylon, dacron, silastic, etc.

The present invention may be understood more fully by reference to the following figures in which:

FIG. 1 is a sketch of an intrauterine device in accordance with the present invention;

FIGS. 2 and 3 are sectional views of the uterine cavity showing the disposition of the intrauterine device of the present invention therein; and

FIGS. 3 to 5 illustrate an inserter adapted for the implantation of the intrauterine device of the present invention.

As already described, the intrauterine device of the present invention takes the form of a T as illustrated in FIG. 1. The top cross bar 11 is of a length in the order of 30 to 38 mm. and the depending leg 12 is in the order of 35 to 40 mm. The diameter of the crossbar 11 and depending leg 12 is typically in the order of l to 4 mm. The lengths of the crossbar 11 and the leg 12 are selected so that the device will fit naturally within the uterine cavity as illustrated in FIG. 2 with the cross bar 11 extending across the fundus 15 of the uterus and the depending leg 12 extending down toward the os 16.

While the present invention is not to be limited by any theory, on the basis of studies which have been performed, the intrauterine device of the present invention is believed to function in the following manner:

Typically, the device of the present invention is of such a size that the crossbar of the T may exert some lateral pressure on the endometrial wall of the uterus. X-ray studies indicate that the ends of the crossbar will become slightly imbedded in the endometrium at 17 this suggesting a gentle anchoring phenomenon. However, it is believed that by using materials of thin cross section, anterior-posterior and lateral pressure on the walls of the uterus are reduced.

As illustrated in FIG. 3, the uterine muscle 14 when in its normal relaxed condition causes an obliteration of the endometrial cavity. While commonly referred to as a cavity, in the relaxed condition the uterus in fact contains little or no volume of fluids since the muscle walls are collapsed against each other. It is as a consequence of this normal relaxedcondition that intrauterine devices adapted to fill the uterine cavity necessarily must apply some anterior-posterior and lateral pressures upon the uterine muscles in order to force apart the collapsed fold of the cavity. It is the pressure applied to the muscle in this fashion which is believed to lead to the involuntary expulsion reaction of these muscles and to the other common side effects of intrauterine devices such as bleeding and/or pain. As illustrated in FIGS. 2 and 3, the intrauterine device 10 of the present invention is adapted to lie essentially in the fold of the relaxed uterine muscle and to apply only minimal anterior-posterior and lateral pressure upon those muscles and upon their mucosal lining.

As illustrated in FIGS. 4 to 6, the inserter for implanting the intrauterine device of the present invention comprises an. elongated tube 20 adapted to be extended through the cervical 0s and into the uterine cavity. The tubular element 20 is provided with a suitable indicator 22 to permit the physician to gauge the position of the inserter device in use and a suitable finger grip 24 for easy gripping and manipulation of the tubular element with the fingers.

When it is loaded for implantation, the intrauterine device of the present invention is placed into the distal end of the inserter tube 20 as shown in FIG. 4. The extended arms 11 of the "T" are pressed down along the outer walls ofthe tube 20 into a pair of grooves 26 formed in the sides thereof. The grooves 26, as shown most clearly in FIG. 6, are of a size and shape adapted to grip the folded arms 11 and to retain them while the inserter tube with the intrauterine device of the present invention is inserted through the cervical 05 into the utenne cavity. Upon locating the inserter tube in the desired position the patient, the intrauterine device is expelled therefrom by means of a plunger 28 which extends through the inserter 20 (this plunger 28 being shown separately in FIG. 5).

EXAMPLES Clinical studies have been performed on expulsion rates of the intrauterine T" of the present invention in comparison with a typical plastic loop intrauterine device such as has been recommended heretofore. The plastic loop used in these studies had a generally sinuous shape in which the height was in the order of 23 mm. and the maximum lateraldimension was in the order of 27 mm. The T" used in these studies had a dimension of 32 mm. across the top of the T and a leg of 36 mm. and was formed of polyethylene 1% mm. in diameter. The results are set forth in the following table.

NET CUMULATIVE RATES OF TERMINATION PER USERS SELECTED DEVICESNINE MONTHS OF USE These data show that involuntary expulsions for patients wearing the device of the present invention are substantially lower than for patients wearing conventional loops. This was observed both for the first expulsion of an intrauterine device as well as for subsequent expulsion after re-insertion. Medical removals because of contraindications or objectionable irritation was dramatically reduced. As a consequence. even through the unintentional pregnancy rate was higher. the percentage of patients who continued with the program was about the same in the group wearing the device of the present invention compared with the control group.

It will be understood that the present invention may be combined with other methods of contraception to provide improved effectiveness. For example, it has been found that certain metals such as copper or zinc produced unexplained improvement in the contraceptive efficiency of intrauterine devices. These metals may be plated on to the device of the present invention. or a small sheath of foil or wire of such a LII metal or an alloy thereof may be wrapped around a portion of the "T. In still another modification, the T of this invention may be prepared from a plastic into which a contraceptive drug has been incorporated.

lclaim:

1. An intrauterine contraceptive device substantially in the shape of a T" said T" having a crossbar of between about 30 and 38 mm. in length and a depending leg ofbetween about 35 and 40 mm. the cross-sectional dimensions of said crossbar and said leg being in the order of l to 4 mm.. said 1" being adapted to lie within the fold of the uterine cavity.

2. In the method of contraception wherein an intrauterine device is placed within the uterus, the improvement comprising employing as said intrauterine device a T having a crossbar of from 30 to 38 mm. in length and a depending leg of from 35 to 40 mm., the cross-sectional dimensions of said crossbar and said leg being from I to 4 mm.. said T being adapted to lie within the fold of the uterine cavity.

US3533406A 1968-09-18 1968-09-18 Intrauterine contraceptive device Expired - Lifetime US3533406A (en)

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Cited By (71)

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US3711035A (en) * 1971-08-12 1973-01-16 Population Council Inc Filament winding apparatus
DE2247949A1 (en) * 1971-09-30 1973-04-05 Alza Corp Device for administration of medicines to
US3783861A (en) * 1971-06-11 1974-01-08 Searle & Co Inserter for intrauterine devices
US3845761A (en) * 1970-06-02 1974-11-05 Alza Corp Intrauterine contraceptive anti-fertility device for the management of reproduction
US3880156A (en) * 1972-11-21 1975-04-29 Seymour Hoff Inserter for contraceptive device
DE2361206A1 (en) * 1973-12-06 1975-06-19 Schering Ag Intra-uterine device contg. active medicaments - and mfd. from plastic materials
US3898986A (en) * 1972-12-27 1975-08-12 Alza Corp Biotransformable intrauterine device
DE2505104A1 (en) * 1974-02-14 1975-08-21 Multilan Sa contraceptive device
US3902483A (en) * 1974-08-21 1975-09-02 Alza Corp Intrauterine device with locator means for indicating uterine position of device
US3913573A (en) * 1972-10-02 1975-10-21 Morton Gutnick Intrauterine contraceptive devices with plural parallel leg segments
US3935860A (en) * 1974-08-21 1976-02-03 Alza Corporation Intrauterine device with restrictor for maintaining device in uterine cavity
US3937217A (en) * 1973-03-19 1976-02-10 Outokumpu Oy Intrauterine contraceptive device
US3971367A (en) * 1972-12-27 1976-07-27 Alza Corporation Intrauterine device having means for changing from uterine-retentive shape to nonuterine-retentive shape
US3993058A (en) * 1974-08-21 1976-11-23 Alza Corporation Intrauterine device with seeker for finding the cervical os and housing member for fitting device in an inserter
US4026281A (en) * 1973-10-12 1977-05-31 Ortho Pharmaceutical Corporation Method and apparatus for inserting an intrauterine contraceptive device
US4040417A (en) * 1970-12-01 1977-08-09 G. D. Searle & Co. Intrauterine device
US4143656A (en) * 1977-03-28 1979-03-13 Ortho Pharmaceutical Corporation Instrument and method for inserting an intrauterine contraceptive device
EP0152193A1 (en) * 1984-01-23 1985-08-21 Ortho Pharmaceutical (Canada) Ltd Streamlined t-shaped intrauterine device and method of preventing conception
US5146931A (en) * 1988-08-15 1992-09-15 Kurz Karl Heinz Device to be placed in the uterus
US6929621B2 (en) 2002-10-02 2005-08-16 Civco Medical Instruments Co., Inc. Drainage catheter with bifurcating tip
US20070151565A1 (en) * 2003-10-16 2007-07-05 Guillermo Sanders Acedo Method for the production and positioning of an intrauterine device which is adapted to the uterine cavity measurements
JP2008534197A (en) * 2005-04-05 2008-08-28 バイエル シェーリング ファーマ オイ How to improve the system and the ultrasonic detecting ultrasonically detectable intrauterine
US7601165B2 (en) 2006-09-29 2009-10-13 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable suture loop
US7608092B1 (en) 2004-02-20 2009-10-27 Biomet Sports Medicince, LLC Method and apparatus for performing meniscus repair
US7749250B2 (en) 2006-02-03 2010-07-06 Biomet Sports Medicine, Llc Soft tissue repair assembly and associated method
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US3845761A (en) * 1970-06-02 1974-11-05 Alza Corp Intrauterine contraceptive anti-fertility device for the management of reproduction
US4040417A (en) * 1970-12-01 1977-08-09 G. D. Searle & Co. Intrauterine device
US3783861A (en) * 1971-06-11 1974-01-08 Searle & Co Inserter for intrauterine devices
US3711035A (en) * 1971-08-12 1973-01-16 Population Council Inc Filament winding apparatus
DE2247949A1 (en) * 1971-09-30 1973-04-05 Alza Corp Device for administration of medicines to
FR2158201A1 (en) * 1971-09-30 1973-06-15 Alza Corp Intrauterine medication dispenser - esp contraceptive device with permeable plastic tube continuously dispensing the medica
US3913573A (en) * 1972-10-02 1975-10-21 Morton Gutnick Intrauterine contraceptive devices with plural parallel leg segments
US3880156A (en) * 1972-11-21 1975-04-29 Seymour Hoff Inserter for contraceptive device
US3898986A (en) * 1972-12-27 1975-08-12 Alza Corp Biotransformable intrauterine device
US3971367A (en) * 1972-12-27 1976-07-27 Alza Corporation Intrauterine device having means for changing from uterine-retentive shape to nonuterine-retentive shape
US3937217A (en) * 1973-03-19 1976-02-10 Outokumpu Oy Intrauterine contraceptive device
US4026281A (en) * 1973-10-12 1977-05-31 Ortho Pharmaceutical Corporation Method and apparatus for inserting an intrauterine contraceptive device
DE2361206A1 (en) * 1973-12-06 1975-06-19 Schering Ag Intra-uterine device contg. active medicaments - and mfd. from plastic materials
US3952734A (en) * 1974-02-14 1976-04-27 Multilan S.A. Intra-uterine-device
DE2505104A1 (en) * 1974-02-14 1975-08-21 Multilan Sa contraceptive device
US3935860A (en) * 1974-08-21 1976-02-03 Alza Corporation Intrauterine device with restrictor for maintaining device in uterine cavity
US3902483A (en) * 1974-08-21 1975-09-02 Alza Corp Intrauterine device with locator means for indicating uterine position of device
US3993058A (en) * 1974-08-21 1976-11-23 Alza Corporation Intrauterine device with seeker for finding the cervical os and housing member for fitting device in an inserter
US4143656A (en) * 1977-03-28 1979-03-13 Ortho Pharmaceutical Corporation Instrument and method for inserting an intrauterine contraceptive device
JPS60215355A (en) * 1984-01-23 1985-10-28 Ooso Pharm Kanada Ltd Streamline t-shaped intrauterine apparatus
EP0152193A1 (en) * 1984-01-23 1985-08-21 Ortho Pharmaceutical (Canada) Ltd Streamlined t-shaped intrauterine device and method of preventing conception
JPH0675584B2 (en) 1984-01-23 1994-09-28 オーソ・フアーマシユーチカル・(カナダ)・リミテツド T-shaped intrauterine contraceptive device
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