ITBO20050388A1 - Formulazione mucoadesive utili in dispositivi medici in preparazioni farmaceutiche - Google Patents

Formulazione mucoadesive utili in dispositivi medici in preparazioni farmaceutiche

Info

Publication number
ITBO20050388A1
ITBO20050388A1 IT000388A ITBO20050388A ITBO20050388A1 IT BO20050388 A1 ITBO20050388 A1 IT BO20050388A1 IT 000388 A IT000388 A IT 000388A IT BO20050388 A ITBO20050388 A IT BO20050388A IT BO20050388 A1 ITBO20050388 A1 IT BO20050388A1
Authority
IT
Italy
Prior art keywords
medical devices
mucoadesives
mucous membranes
pharmaceutical preparations
formulations
Prior art date
Application number
IT000388A
Other languages
English (en)
Inventor
Giuseppe Bottoni
Carla Caramella
Mascia Federici
Paola Maffei
Silvia Rossi
Annalisa Sforzini
Giuseppe Claudio Viscomi
Original Assignee
Alfa Wassermann Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa
Priority to IT000388A priority Critical patent/ITBO20050388A1/it
Priority to UAA200711344A priority patent/UA90507C2/uk
Priority to SI200630188T priority patent/SI1898876T1/sl
Priority to ES06754047T priority patent/ES2318756T3/es
Priority to DK06754047T priority patent/DK1898876T3/da
Priority to JP2008514019A priority patent/JP5118633B2/ja
Priority to BRPI0611400A priority patent/BRPI0611400B8/pt
Priority to CA2604768A priority patent/CA2604768C/en
Priority to PT06754047T priority patent/PT1898876E/pt
Priority to US11/921,286 priority patent/US20090081133A1/en
Priority to CN2010105570198A priority patent/CN102079794B/zh
Priority to RU2007143998/15A priority patent/RU2403012C2/ru
Priority to PCT/EP2006/005240 priority patent/WO2006131262A1/en
Priority to PL06754047T priority patent/PL1898876T3/pl
Priority to CN2006800176445A priority patent/CN101180036B/zh
Priority to EP06754047A priority patent/EP1898876B1/en
Priority to KR1020077028142A priority patent/KR101337578B1/ko
Priority to DE602006004451T priority patent/DE602006004451D1/de
Priority to MX2007015074A priority patent/MX2007015074A/es
Priority to AT06754047T priority patent/ATE418324T1/de
Publication of ITBO20050388A1 publication Critical patent/ITBO20050388A1/it
Priority to IL186655A priority patent/IL186655A/en
Priority to NO20076083A priority patent/NO338991B1/no
Priority to CY20091100281T priority patent/CY1108875T1/el
Priority to US13/277,130 priority patent/US20120088726A1/en
Priority to US13/747,889 priority patent/US20130183325A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Virology (AREA)
IT000388A 2005-06-06 2005-06-06 Formulazione mucoadesive utili in dispositivi medici in preparazioni farmaceutiche ITBO20050388A1 (it)

Priority Applications (25)

Application Number Priority Date Filing Date Title
IT000388A ITBO20050388A1 (it) 2005-06-06 2005-06-06 Formulazione mucoadesive utili in dispositivi medici in preparazioni farmaceutiche
UAA200711344A UA90507C2 (uk) 2005-06-06 2006-01-06 Мукоадгезивна композиція для приготування медичних засобів та фармацевтичних композицій
RU2007143998/15A RU2403012C2 (ru) 2005-06-06 2006-06-01 Мукоадгезивные ксилоглюкансодержащие препараты, полезные в медицинских устройствах и в фармацевтических препаратах
PL06754047T PL1898876T3 (pl) 2005-06-06 2006-06-01 Preparaty mukoadhezyjne zawierające ksyloglukan, użyteczne w wyrobach medycznych i preparatach farmaceutycznych
DK06754047T DK1898876T3 (da) 2005-06-06 2006-06-01 Mucoadhæsive xyloglucanholdige fprmuleringer anvendelige i medicinske anordninger og i farmaceutiske former
JP2008514019A JP5118633B2 (ja) 2005-06-06 2006-06-01 医療用デバイスおよび医薬製剤において有用な粘膜付着性キシログルカン含有製剤
BRPI0611400A BRPI0611400B8 (pt) 2005-06-06 2006-06-01 formulações contendo xiloglicano muco-adesivas úteis em dispositivos médicos e em formulações farmacêuticas
CA2604768A CA2604768C (en) 2005-06-06 2006-06-01 Mucoadhesive xyloglucan-containing formulations useful in medical devices and in pharmaceutical formulations
PT06754047T PT1898876E (pt) 2005-06-06 2006-06-01 Formulações mucoadesivas contendo xiloglucano úteis em dispositivos médicos e em formulações farmacêuticas
US11/921,286 US20090081133A1 (en) 2005-06-06 2006-06-01 Mucoadhesive xyloglucan-containing formulations useful in medical devices and in pharmaceutical fromulations
CN2010105570198A CN102079794B (zh) 2005-06-06 2006-06-01 用于医药装置和药物制剂中的含有木葡聚糖的粘膜粘附性制剂
SI200630188T SI1898876T1 (sl) 2005-06-06 2006-06-01 MUKOADHEZIVNE FARMACEVTSKE OBLIKE, KI VSEBUJEJO KSILOGlUKAN IN SO UPORABNE V MEDICINSKIH SREDSTVIH IN APLIKACIJSKIH OBLIKAH
PCT/EP2006/005240 WO2006131262A1 (en) 2005-06-06 2006-06-01 Mucoadhesive xyloglucan-containing formulations useful in medical devices and in pharmaceutical formulations
ES06754047T ES2318756T3 (es) 2005-06-06 2006-06-01 Formulaciones mucoadhesivas que contienen xiloglucano utiles en dispositivos medicos y en presentaciones farmaceuticas.
CN2006800176445A CN101180036B (zh) 2005-06-06 2006-06-01 用于医药装置和药物制剂中的含有木葡聚糖的粘膜粘附性制剂
EP06754047A EP1898876B1 (en) 2005-06-06 2006-06-01 Mucoadhesive xyloglucan-containing formulations useful in medical devices and in pharmaceutical presentations
KR1020077028142A KR101337578B1 (ko) 2005-06-06 2006-06-01 의료 장치 및 의약 제형에 유용한 점막 접착성 자일로글루칸 함유 제형
DE602006004451T DE602006004451D1 (de) 2005-06-06 2006-06-01 Mucoadhäsive xyloglucan-haltige formulierung für medizinprodukte und pharmazeutische darreichungsformen
MX2007015074A MX2007015074A (es) 2005-06-06 2006-06-01 Formulaciones que contienen xiloglucano mucoadhesivo util en dispositivos medicos y en formulaciones farmaceuticas.
AT06754047T ATE418324T1 (de) 2005-06-06 2006-06-01 Mucoadhäsive xyloglucan-haltige formulierung für medizinprodukte und pharmazeutische darreichungsformen
IL186655A IL186655A (en) 2005-06-06 2007-10-15 Mucoadhesive xyloglucan-containing formulations useful in medical devices and in pharmaceutical formulations and a process for purification of natural polymer having xyloglucan structure
NO20076083A NO338991B1 (no) 2005-06-06 2007-11-26 Mukoadhesive xyloglukaninneholdende formuleringer som er anvendelige i medisinske anordninger og i farmasøytiske formuleringer
CY20091100281T CY1108875T1 (el) 2005-06-06 2009-03-12 Βλεννοπροσφυτικα σκευασματα που περιεχουν ξυλογλυκανη και ειναι χρησιμα σε ιατρικες συσκευες και σε φαρμακευτικα σκευασματα
US13/277,130 US20120088726A1 (en) 2005-06-06 2011-10-19 Mucoadhesive xyloglucan-containing formulations useful in medical devices and in pharmaceutical fromulations
US13/747,889 US20130183325A1 (en) 2005-06-06 2013-01-23 Mucoadhesive xyloglucan-containing formulations useful in medical devices and in pharmaceutical formulations

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000388A ITBO20050388A1 (it) 2005-06-06 2005-06-06 Formulazione mucoadesive utili in dispositivi medici in preparazioni farmaceutiche

Publications (1)

Publication Number Publication Date
ITBO20050388A1 true ITBO20050388A1 (it) 2006-12-07

Family

ID=36954507

Family Applications (1)

Application Number Title Priority Date Filing Date
IT000388A ITBO20050388A1 (it) 2005-06-06 2005-06-06 Formulazione mucoadesive utili in dispositivi medici in preparazioni farmaceutiche

Country Status (22)

Country Link
US (3) US20090081133A1 (it)
EP (1) EP1898876B1 (it)
JP (1) JP5118633B2 (it)
KR (1) KR101337578B1 (it)
CN (2) CN101180036B (it)
AT (1) ATE418324T1 (it)
BR (1) BRPI0611400B8 (it)
CA (1) CA2604768C (it)
CY (1) CY1108875T1 (it)
DE (1) DE602006004451D1 (it)
DK (1) DK1898876T3 (it)
ES (1) ES2318756T3 (it)
IL (1) IL186655A (it)
IT (1) ITBO20050388A1 (it)
MX (1) MX2007015074A (it)
NO (1) NO338991B1 (it)
PL (1) PL1898876T3 (it)
PT (1) PT1898876E (it)
RU (1) RU2403012C2 (it)
SI (1) SI1898876T1 (it)
UA (1) UA90507C2 (it)
WO (1) WO2006131262A1 (it)

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US20090068122A1 (en) * 2007-09-06 2009-03-12 Shira Pilch Dentifrice Compositions for Treating Xerostomia
EP2274015A2 (en) * 2008-04-11 2011-01-19 SemBioSys Genetics Inc. Controlled release of active agents from oleosomes
CA2749746C (en) * 2009-01-27 2014-08-12 Teleflex Medical Incorporated Sputum dissolving suctioning solution for endotracheal and tracheostomy tubes
JP2011001317A (ja) * 2009-06-19 2011-01-06 Fumakilla Ltd 鼻用洗浄剤
IT1397132B1 (it) * 2009-12-01 2013-01-04 Alfa Wassermann Spa Composizioni comprendenti antiinfiammatori non steroidei.
SG185694A1 (en) 2010-05-24 2012-12-28 Indena Spa Tamarind seed polysaccharide for use in the treatment of inflammatory diseases
HUE026862T2 (en) 2010-05-24 2016-07-28 Indena Spa Combined vegetable extracts for use in the treatment of microbiological infections
CN106074278B (zh) 2010-09-09 2020-11-27 玫琳凯有限公司 包含植物提取物的局部护肤制剂
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
EP3936133A1 (en) 2011-11-23 2022-01-12 TherapeuticsMD, Inc. Natural combination hormone replacement formulations and therapies
US9091622B2 (en) 2011-12-20 2015-07-28 Exxonmobil Upstream Research Company Capillary-based calibration standards for measurement of permeability
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
JP6139664B2 (ja) 2012-09-12 2017-05-31 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． ステントおよびステントの作製方法
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
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