DK1556058T3 - Farmaceutiske præparater omfattende östetrolderivater til anvendelse i cancerterapi - Google Patents
Farmaceutiske præparater omfattende östetrolderivater til anvendelse i cancerterapiInfo
- Publication number
- DK1556058T3 DK1556058T3 DK03759076T DK03759076T DK1556058T3 DK 1556058 T3 DK1556058 T3 DK 1556058T3 DK 03759076 T DK03759076 T DK 03759076T DK 03759076 T DK03759076 T DK 03759076T DK 1556058 T3 DK1556058 T3 DK 1556058T3
- Authority
- DK
- Denmark
- Prior art keywords
- oestetrol
- derivatives
- pharmaceutical compositions
- cancer therapy
- estrogen
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02079414 | 2002-10-23 | ||
PCT/NL2003/000718 WO2004037269A1 (en) | 2002-10-23 | 2003-10-23 | Pharmaceutical compositions comprising estetrol derivatives for use in cancer therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1556058T3 true DK1556058T3 (da) | 2008-03-03 |
Family
ID=32116285
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03759076T DK1556058T3 (da) | 2002-10-23 | 2003-10-23 | Farmaceutiske præparater omfattende östetrolderivater til anvendelse i cancerterapi |
Country Status (13)
Country | Link |
---|---|
US (2) | US8987240B2 (da) |
EP (1) | EP1556058B1 (da) |
CN (1) | CN100528167C (da) |
AT (1) | ATE380552T1 (da) |
AU (1) | AU2003274823A1 (da) |
CA (1) | CA2503549C (da) |
CY (1) | CY1107862T1 (da) |
DE (1) | DE60318092T2 (da) |
DK (1) | DK1556058T3 (da) |
ES (1) | ES2298570T3 (da) |
PT (1) | PT1556058E (da) |
SI (1) | SI1556058T1 (da) |
WO (1) | WO2004037269A1 (da) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1526856T1 (sl) | 2002-07-12 | 2008-04-30 | Pantarhei Bioscience Bv | Farmacevtski sestavek, ki obsega estetrolne derivate za uporabo pri zdravljenju raka |
US8987240B2 (en) | 2002-10-23 | 2015-03-24 | Pantarhei Bioscience B.V. | Pharmaceutical compositions comprising estetrol derivatives for use in cancer therapy |
WO2008024484A1 (en) * | 2006-08-25 | 2008-02-28 | Cougar Biotechnology, Inc. | Methods and compositions for treating cancer |
US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
CA2691654C (en) | 2007-06-21 | 2016-06-07 | Pantarhei Bioscience B.V. | Treatment of meconium aspiration syndrome with estrogens |
MX342537B (es) | 2011-06-01 | 2016-10-04 | Estetra Sprl | Proceso para la produccion de intermediarios de estetrol. |
KR101994805B1 (ko) | 2011-06-01 | 2019-07-01 | 에스테트라 에스.피.알.엘. | 에스테트롤 중간체의 제조 방법 |
EP2383279A1 (en) | 2011-07-19 | 2011-11-02 | Pantarhei Bioscience B.V. | Process for the preparation of estetrol |
US20130123222A1 (en) * | 2011-11-10 | 2013-05-16 | Sri International, Inc. | Synergistic Anti-Cancer Activity of SR16388 with Anti-Mitotic Drugs |
CA2856520C (en) | 2011-11-23 | 2021-04-06 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
AU2015264003A1 (en) | 2014-05-22 | 2016-11-17 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
ES2863500T3 (es) | 2015-04-10 | 2021-10-11 | Capsugel Belgium Nv | Formulaciones lipídicas de acetato de abiraterona |
WO2016203044A1 (en) * | 2015-06-18 | 2016-12-22 | Mithra Pharmaceuticals S.A. | Orodispersible tablet containing estetrol |
CU24523B1 (es) | 2015-06-18 | 2021-06-08 | Estetra Sprl | Unidad de dosificación orodispersable que contiene un componente estetrol |
SI3310345T1 (sl) | 2015-06-18 | 2021-05-31 | Estetra Sprl | Orodisperzibilna tableta, ki vsebuje estetrol |
CN116077455A (zh) | 2015-06-18 | 2023-05-09 | 埃斯特拉有限责任公司 | 含雌四醇组分的口腔分散剂量单位 |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
CA3020153A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
CA3031705A1 (en) | 2016-07-29 | 2018-02-01 | Janssen Pharmaceutica Nv | Treatment of prostate cancer with niraparib |
KR20220144885A (ko) | 2016-08-05 | 2022-10-27 | 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 | 월경통 및 생리통의 관리방법 |
RU2758386C2 (ru) * | 2017-08-01 | 2021-10-28 | Фанд Са | Новая вспомогательная терапия для применения в способе лечения рака простаты |
CN109718198A (zh) * | 2017-10-30 | 2019-05-07 | 浙江京新药业股份有限公司 | 一种治疗前列腺癌的注射剂及其制备方法 |
JOP20200260A1 (ar) | 2018-04-19 | 2019-10-19 | Estetra Sprl | مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث |
TWI801561B (zh) | 2018-04-19 | 2023-05-11 | 比利時商依思特拉私人有限責任公司 | 化合物及其用於緩解絕經相關症狀的用途 |
HU231240B1 (hu) | 2019-09-03 | 2022-04-28 | Richter Gedeon Nyrt. | Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására |
US11977085B1 (en) | 2023-09-05 | 2024-05-07 | Elan Ehrlich | Date rape drug detection device and method of using same |
Family Cites Families (49)
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US3440320A (en) * | 1964-06-18 | 1969-04-22 | Mortimer D Sackler | Chelated suppository and method of using same |
US3797494A (en) * | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
DE2336433A1 (de) | 1973-07-13 | 1975-04-03 | Schering Ag | 1.3-oxygenierte 8 alpha-oestratriene |
DE2336434A1 (de) | 1973-07-13 | 1975-04-17 | Schering Ag | 1.3-oxygenierte 8 alpha-oestratriene |
DE2426779A1 (de) | 1974-05-31 | 1975-12-18 | Schering Ag | 1.3-oxygenierte 8 alpha-oestratriene |
US4722941A (en) * | 1978-06-07 | 1988-02-02 | Kali-Chemie Pharma Gmbh | Readily absorbable pharmaceutical compositions of per se poorly absorbable pharmacologically active agents and preparation thereof |
US4460372A (en) * | 1981-02-17 | 1984-07-17 | Alza Corporation | Percutaneous absorption enhancer dispenser for use in coadministering drug and percutaneous absorption enhancer |
US4573996A (en) * | 1984-01-03 | 1986-03-04 | Jonergin, Inc. | Device for the administration of an active agent to the skin or mucosa |
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US5063507A (en) * | 1990-09-14 | 1991-11-05 | Plains Cotton Cooperative Association | Goods database employing electronic title or documentary-type title |
US5340585A (en) * | 1991-04-12 | 1994-08-23 | University Of Southern California | Method and formulations for use in treating benign gynecological disorders |
US5340586A (en) * | 1991-04-12 | 1994-08-23 | University Of Southern California | Methods and formulations for use in treating oophorectomized women |
US5211952A (en) | 1991-04-12 | 1993-05-18 | University Of Southern California | Contraceptive methods and formulations for use therein |
US5162117A (en) | 1991-11-22 | 1992-11-10 | Schering Corporation | Controlled release flutamide composition |
US5468736A (en) * | 1993-02-25 | 1995-11-21 | The Medical College Of Hampton Road | Hormone replacement therapy |
US5895783A (en) | 1993-07-16 | 1999-04-20 | Schering Aktiengesellschaft | Treatment of preeclampsia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor |
NL9301562A (nl) * | 1993-09-09 | 1995-04-03 | Saturnus Ag | Preparaat voor substitutietherapie. |
DE4344405C2 (de) | 1993-12-24 | 1995-12-07 | Marika Dr Med Ehrlich | Ovulationshemmendes Mittel und Verfahren zur hormonalen Kontrazeption |
WO1996003929A1 (en) | 1994-08-04 | 1996-02-15 | Biex, Inc. | Method for prediction of premature delivery using estetrol (e4) as an indicator |
DE4429374C1 (de) * | 1994-08-12 | 1996-02-01 | Jenapharm Gmbh | Pharmazeutische Präparate zur Kontrazeption/Hormonsubstitution mit biogener Estrogenkomponente |
EP0994718B1 (en) | 1997-06-20 | 2005-08-17 | Akzo Nobel N.V. | Gonadotropin releasing hormone antagonist |
DE19739916C2 (de) * | 1997-09-11 | 2001-09-13 | Hesch Rolf Dieter | Verwendung einer Kombination aus einem Gestagen und einem Estrogen zur kontinuierlichen Ovulationshemmung und ggf. gleichzeitigen Behandlung und/oder Prophylaxe von Tumoren der Brustdrüsen |
US20020013304A1 (en) * | 1997-10-28 | 2002-01-31 | Wilson Leland F. | As-needed administration of an androgenic agent to enhance female sexual desire and responsiveness |
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AU5137900A (en) | 1999-05-28 | 2000-12-18 | University Of Cincinnati, The | Antisense oligonucleotides for fertility and menstrual cycle regulation and for chemopreventive and chemotherapeutic use |
WO2001030356A1 (fr) | 1999-10-25 | 2001-05-03 | Laboratoire Theramex | Composition hormonale a base d'un progestatif et d'un estrogene et son utilisation |
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CO5271709A1 (es) * | 2000-01-12 | 2003-04-30 | Pfizer Prod Inc | Composiciones y procedimientos para el y tratamiento de afecciones que responden a estrogenos |
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CA2462081A1 (en) * | 2000-10-11 | 2002-04-18 | Laura Kragie | Composition and method of alleviating adverse side effects and/or enhancing efficacy of agents that inhibit aromatase |
MXPA03006958A (es) * | 2001-02-05 | 2003-11-18 | Upjohn Co | Composicion para administracion rectal de farmaco antibacterial de oxazolidinona. |
AU2002240949A1 (en) * | 2001-03-21 | 2002-10-03 | Schering Aktiengesellschaft | Pharmaceutical combined preparations containing aromatase inhibitors and substances having an estrogen effect in addition to the use thereof for producing a medicament for estrogen-replacement-therapy |
US6936599B2 (en) * | 2001-04-25 | 2005-08-30 | The Regents Of The University Of California | Estriol therapy for multiple sclerosis and other autoimmune diseases |
EP1293210B1 (en) | 2001-05-23 | 2003-11-19 | Pantarhei Bioscience B.V. | Means and method for hormonal contraception |
ATE350041T1 (de) * | 2001-05-18 | 2007-01-15 | Pantarhei Bioscience Bv | Pharmaceutishe zusammensetzung für die hormonersatztherapie |
EP1260225A1 (en) | 2001-05-18 | 2002-11-27 | Pantarhei Bioscience B.V. | A pharmaceutical composition for use in hormone replacement therapy |
CA2448273C (en) | 2001-05-23 | 2010-06-29 | Christian Franz Holinka | Drug delivery system comprising a tetrahydroxylated estrogen for use in hormonal contraception |
DK1390042T3 (da) | 2001-05-23 | 2008-03-31 | Pantarhei Bioscience Bv | System for administration af et lægemiddel omfattende tetrahydroxyleret östrogen til anvendelse i hormonal svangerskabsforebyggelse |
US20040198707A1 (en) | 2001-05-23 | 2004-10-07 | Agatha Antonia Magdalena Van Beek | Means and method for hormonal contraception |
GB0112617D0 (en) | 2001-05-23 | 2001-07-18 | Hoffmann La Roche | Antiviral nucleoside derivatives |
US6790979B2 (en) * | 2002-04-17 | 2004-09-14 | University Of North Carolina At Chapel Hill | Curcumin analogues and uses thereof |
US8987240B2 (en) | 2002-10-23 | 2015-03-24 | Pantarhei Bioscience B.V. | Pharmaceutical compositions comprising estetrol derivatives for use in cancer therapy |
-
2003
- 2003-10-23 US US10/532,320 patent/US8987240B2/en active Active
- 2003-10-23 DE DE60318092T patent/DE60318092T2/de not_active Expired - Lifetime
- 2003-10-23 WO PCT/NL2003/000718 patent/WO2004037269A1/en active IP Right Grant
- 2003-10-23 AT AT03759076T patent/ATE380552T1/de active
- 2003-10-23 ES ES03759076T patent/ES2298570T3/es not_active Expired - Lifetime
- 2003-10-23 PT PT03759076T patent/PT1556058E/pt unknown
- 2003-10-23 AU AU2003274823A patent/AU2003274823A1/en not_active Abandoned
- 2003-10-23 DK DK03759076T patent/DK1556058T3/da active
- 2003-10-23 CN CNB2003801074356A patent/CN100528167C/zh not_active Expired - Lifetime
- 2003-10-23 SI SI200331061T patent/SI1556058T1/sl unknown
- 2003-10-23 CA CA2503549A patent/CA2503549C/en not_active Expired - Lifetime
- 2003-10-23 EP EP03759076A patent/EP1556058B1/en not_active Expired - Lifetime
-
2008
- 2008-01-18 CY CY20081100080T patent/CY1107862T1/el unknown
-
2015
- 2015-02-12 US US14/621,267 patent/US9561238B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU2003274823A1 (en) | 2004-05-13 |
CA2503549A1 (en) | 2004-05-06 |
EP1556058A1 (en) | 2005-07-27 |
CN1732007A (zh) | 2006-02-08 |
CN100528167C (zh) | 2009-08-19 |
EP1556058B1 (en) | 2007-12-12 |
SI1556058T1 (sl) | 2008-02-29 |
CY1107862T1 (el) | 2013-06-19 |
ATE380552T1 (de) | 2007-12-15 |
US20150150887A1 (en) | 2015-06-04 |
WO2004037269A1 (en) | 2004-05-06 |
CA2503549C (en) | 2012-07-10 |
PT1556058E (pt) | 2008-03-20 |
ES2298570T3 (es) | 2008-05-16 |
DE60318092D1 (de) | 2008-01-24 |
US8987240B2 (en) | 2015-03-24 |
US20060247221A1 (en) | 2006-11-02 |
DE60318092T2 (de) | 2008-11-27 |
US9561238B2 (en) | 2017-02-07 |
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