ATE344670T1 - Synergistische kombination zur behandlung von kolorektalkarzinom - Google Patents

Synergistische kombination zur behandlung von kolorektalkarzinom

Info

Publication number
ATE344670T1
ATE344670T1 AT01933683T AT01933683T ATE344670T1 AT E344670 T1 ATE344670 T1 AT E344670T1 AT 01933683 T AT01933683 T AT 01933683T AT 01933683 T AT01933683 T AT 01933683T AT E344670 T1 ATE344670 T1 AT E344670T1
Authority
AT
Austria
Prior art keywords
treatment
colorectal carcinoma
synergistic combination
derivative
camptothecin
Prior art date
Application number
AT01933683T
Other languages
English (en)
Inventor
Marie-Christine Bissery
Original Assignee
Pfizer Entpr Sarl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Entpr Sarl filed Critical Pfizer Entpr Sarl
Application granted granted Critical
Publication of ATE344670T1 publication Critical patent/ATE344670T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT01933683T 2000-02-28 2001-02-26 Synergistische kombination zur behandlung von kolorektalkarzinom ATE344670T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18537800P 2000-02-28 2000-02-28
US20893800P 2000-06-05 2000-06-05

Publications (1)

Publication Number Publication Date
ATE344670T1 true ATE344670T1 (de) 2006-11-15

Family

ID=26881090

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01933683T ATE344670T1 (de) 2000-02-28 2001-02-26 Synergistische kombination zur behandlung von kolorektalkarzinom

Country Status (28)

Country Link
US (3) US6503889B2 (de)
EP (1) EP1278518B1 (de)
JP (1) JP2003523980A (de)
KR (1) KR100717916B1 (de)
CN (1) CN1424912A (de)
AT (1) ATE344670T1 (de)
AU (1) AU785467B2 (de)
BR (1) BR0108728A (de)
CA (1) CA2401191C (de)
CY (1) CY1105803T1 (de)
CZ (1) CZ298259B6 (de)
DE (1) DE60124387T2 (de)
DK (1) DK1278518T3 (de)
EA (1) EA005619B1 (de)
EE (1) EE200200471A (de)
ES (1) ES2273841T3 (de)
HR (1) HRP20020658A2 (de)
HU (1) HUP0300848A3 (de)
IL (1) IL150953A0 (de)
MX (1) MXPA02008355A (de)
NO (1) NO324772B1 (de)
NZ (1) NZ520593A (de)
PL (1) PL363110A1 (de)
PT (1) PT1278518E (de)
SK (1) SK12242002A3 (de)
TW (1) TWI239841B (de)
WO (1) WO2001062235A2 (de)
YU (1) YU64602A (de)

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GB9808052D0 (en) 1998-04-17 1998-06-17 Secr Defence Implants for administering substances and methods of producing implants
US20080113025A1 (en) * 1998-11-02 2008-05-15 Elan Pharma International Limited Compositions comprising nanoparticulate naproxen and controlled release hydrocodone
US20030092608A1 (en) * 2001-08-21 2003-05-15 Takayuki Kawaguchi Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor
US7026301B2 (en) * 2002-10-17 2006-04-11 New York University Method of orally treating inflammatory skin conditions with prodrugs of 5-fluorouracil
ITMI20030317A1 (it) * 2003-02-21 2004-08-22 Pharmacia Italia Spa Terapia combinata comprendente un derivato dell'indolopirrolocarbazolo ed un altro agente antitumorale.
US20050153885A1 (en) * 2003-10-08 2005-07-14 Yun Anthony J. Treatment of conditions through modulation of the autonomic nervous system
CA2544320A1 (en) * 2003-11-13 2005-06-02 Pharma Mar, S.A.U. Method of treating cancer using a combination comprising et-743 and 5-fluorouracil
BRPI0509732A (pt) 2004-04-09 2007-09-25 Chugai Pharmaceutical Co Ltd pró-fármaco solúvel em água, composição farmacêutica, agente terapêutico, agente antifungo e uso do referido pró-fármaco
CA2566156A1 (en) * 2004-05-28 2005-12-08 Pfizer Products Inc. Method for treating abnormal cell growth
JP2008501677A (ja) * 2004-06-04 2008-01-24 ファイザー・プロダクツ・インク 異常な細胞増殖を治療する方法
BRPI0511765A (pt) * 2004-06-04 2008-01-08 Smithkline Beechman Cork Ltd métodos de tratar cáncer de mama, de pulmão, e colo-retal em um mamìfero
US8569277B2 (en) 2004-08-11 2013-10-29 Palo Alto Investors Methods of treating a subject for a condition
JP2008535920A (ja) * 2005-04-12 2008-09-04 エラン・ファルマ・インターナショナル・リミテッド 癌の治療のための、フルオロシチジン誘導体を含む改変放出組成物
SG162753A1 (en) * 2005-06-07 2010-07-29 Univ Yale Methods of treating cancer and other conditions or disease states using lfmau and ldt
TW200744603A (en) * 2005-08-22 2007-12-16 Chugai Pharmaceutical Co Ltd Novel anticancer concomitant drug
CN102405042A (zh) 2009-05-04 2012-04-04 普西维达公司 多孔硅药物洗脱颗粒
LT3117709T (lt) * 2010-03-12 2018-11-26 Genzyme Corporation Kombinuota terapija krūties vėžio gydymui
TWI615150B (zh) 2010-11-01 2018-02-21 匹史維迪亞美利堅公司 用於傳遞治療劑之生物可分解之以矽為主的裝置
JP2016512839A (ja) 2013-03-15 2016-05-09 シヴィダ・ユーエス・インコーポレイテッドＰｓｉｖｉｄａ Ｕｓ， Ｉｎｃ． 治療物質の送達のための生体内分解性ケイ素系組成物

Family Cites Families (25)

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Publication number Priority date Publication date Assignee Title
JPS57116074A (en) 1981-01-09 1982-07-19 Yakult Honsha Co Ltd Novel camptothecin derivative and its preparation
US4399276A (en) 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
JPS57116015A (en) 1981-01-09 1982-07-19 Yakult Honsha Co Ltd Antitumor agent
US4473692A (en) 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS58154582A (ja) 1982-03-10 1983-09-14 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体およびその製造法
JPS595188A (ja) 1982-06-30 1984-01-12 Yakult Honsha Co Ltd １０−ヒドロキシカンプトテシンの製造法
JPS5951289A (ja) 1982-09-17 1984-03-24 Yakult Honsha Co Ltd 新規な９−置換−カンプトテシン誘導体
JPS6019790A (ja) 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
US4981968A (en) 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
CA1332413C (en) 1987-06-25 1994-10-11 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
US5004758A (en) 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH0615547B2 (ja) 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
JP2524804B2 (ja) 1988-03-29 1996-08-14 株式会社ヤクルト本社 新規なカンプトテシン誘導体及びその製造法
JP2524803B2 (ja) 1988-03-29 1996-08-14 株式会社ヤクルト本社 新規なカンプトテシン誘導体およびその製造法
US5552154A (en) * 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
ES2086643T3 (es) 1991-10-29 1996-07-01 Glaxo Wellcome Inc Derivados de camptotecina solubles en agua.
AU671491B2 (en) * 1992-12-18 1996-08-29 F. Hoffmann-La Roche Ag N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
US6504029B1 (en) 1995-04-10 2003-01-07 Daiichi Pharmaceutical Co., Ltd. Condensed-hexacyclic compounds and a process therefor
GB9510716D0 (en) 1995-05-26 1995-07-19 Pharmacia Spa Substituted camptothecin derivatives and process for their preparation
US5670500A (en) 1995-05-31 1997-09-23 Smithkline Beecham Corporation Water soluble camptothecin analogs
US5663177A (en) 1995-05-31 1997-09-02 Smithkline Beecham Corporation Water soluble camptothecin analogs
EP1251125B1 (de) 1995-06-21 2005-12-07 Société de Conseils et de Recherches d'Applications Scientifiques (S.C.R.A.S.) Camptothecinanaloge, Verfahren zur ihrer Herstellung, ihre Verwendung als Arzneimittel und diese enthaltende pharmazeutische Zusammensetzungen
BR9916735A (pt) * 1998-12-31 2001-09-25 Sugen Inc Compostos de 3-heteroarilidenil-2-indolinona para a modulação da atividade das cinases protéicas e para uso na quimioterapia do cancêr
US6191119B1 (en) 1999-10-15 2001-02-20 Supergen, Inc. Combination therapy including 9-nitro-20(S)-camptothecin
GB9925127D0 (en) * 1999-10-22 1999-12-22 Pharmacia & Upjohn Spa Oral formulations for anti-tumor compounds

Also Published As

Publication number Publication date
TWI239841B (en) 2005-09-21
US6503889B2 (en) 2003-01-07
DK1278518T3 (da) 2007-01-15
US6664242B2 (en) 2003-12-16
EA005619B1 (ru) 2005-04-28
KR100717916B1 (ko) 2007-05-11
BR0108728A (pt) 2003-12-30
SK12242002A3 (sk) 2003-02-04
EA200200922A1 (ru) 2003-04-24
JP2003523980A (ja) 2003-08-12
ES2273841T3 (es) 2007-05-16
NO20024076L (no) 2002-08-27
KR20020082856A (ko) 2002-10-31
CA2401191C (en) 2006-05-02
CZ298259B6 (cs) 2007-08-08
NZ520593A (en) 2004-10-29
DE60124387T2 (de) 2007-10-11
YU64602A (sh) 2005-06-10
US20030096789A1 (en) 2003-05-22
HUP0300848A3 (en) 2005-03-29
WO2001062235A2 (en) 2001-08-30
EP1278518B1 (de) 2006-11-08
US20020091132A1 (en) 2002-07-11
CN1424912A (zh) 2003-06-18
EP1278518A2 (de) 2003-01-29
PL363110A1 (en) 2004-11-15
WO2001062235A3 (en) 2002-11-14
EE200200471A (et) 2003-12-15
MXPA02008355A (es) 2002-12-13
NO20024076D0 (no) 2002-08-27
CA2401191A1 (en) 2001-08-30
IL150953A0 (en) 2003-02-12
HRP20020658A2 (en) 2004-12-31
AU6011101A (en) 2001-09-03
NO324772B1 (no) 2007-12-10
CZ20022892A3 (cs) 2002-11-13
HUP0300848A2 (hu) 2003-08-28
US20020068743A1 (en) 2002-06-06
PT1278518E (pt) 2007-01-31
DE60124387D1 (de) 2006-12-21
AU785467B2 (en) 2007-07-26
CY1105803T1 (el) 2011-02-02

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