DK1278518T3 - Synergistisk kombination til behandling af colorektal cancer - Google Patents

Synergistisk kombination til behandling af colorektal cancer

Info

Publication number
DK1278518T3
DK1278518T3 DK01933683T DK01933683T DK1278518T3 DK 1278518 T3 DK1278518 T3 DK 1278518T3 DK 01933683 T DK01933683 T DK 01933683T DK 01933683 T DK01933683 T DK 01933683T DK 1278518 T3 DK1278518 T3 DK 1278518T3
Authority
DK
Denmark
Prior art keywords
treatment
colorectal cancer
synergistic combination
derivative
camptothecin
Prior art date
Application number
DK01933683T
Other languages
English (en)
Inventor
Marie-Christine Bissery
Original Assignee
Pfizer Entpr Sarl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Entpr Sarl filed Critical Pfizer Entpr Sarl
Application granted granted Critical
Publication of DK1278518T3 publication Critical patent/DK1278518T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
DK01933683T 2000-02-28 2001-02-26 Synergistisk kombination til behandling af colorektal cancer DK1278518T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18537800P 2000-02-28 2000-02-28
US20893800P 2000-06-05 2000-06-05

Publications (1)

Publication Number Publication Date
DK1278518T3 true DK1278518T3 (da) 2007-01-15

Family

ID=26881090

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01933683T DK1278518T3 (da) 2000-02-28 2001-02-26 Synergistisk kombination til behandling af colorektal cancer

Country Status (28)

Country Link
US (3) US6503889B2 (da)
EP (1) EP1278518B1 (da)
JP (1) JP2003523980A (da)
KR (1) KR100717916B1 (da)
CN (1) CN1424912A (da)
AT (1) ATE344670T1 (da)
AU (1) AU785467B2 (da)
BR (1) BR0108728A (da)
CA (1) CA2401191C (da)
CY (1) CY1105803T1 (da)
CZ (1) CZ298259B6 (da)
DE (1) DE60124387T2 (da)
DK (1) DK1278518T3 (da)
EA (1) EA005619B1 (da)
EE (1) EE200200471A (da)
ES (1) ES2273841T3 (da)
HR (1) HRP20020658A2 (da)
HU (1) HUP0300848A3 (da)
IL (1) IL150953A0 (da)
MX (1) MXPA02008355A (da)
NO (1) NO324772B1 (da)
NZ (1) NZ520593A (da)
PL (1) PL363110A1 (da)
PT (1) PT1278518E (da)
SK (1) SK12242002A3 (da)
TW (1) TWI239841B (da)
WO (1) WO2001062235A2 (da)
YU (1) YU64602A (da)

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US20080113025A1 (en) * 1998-11-02 2008-05-15 Elan Pharma International Limited Compositions comprising nanoparticulate naproxen and controlled release hydrocodone
US20030092608A1 (en) * 2001-08-21 2003-05-15 Takayuki Kawaguchi Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor
US7026301B2 (en) * 2002-10-17 2006-04-11 New York University Method of orally treating inflammatory skin conditions with prodrugs of 5-fluorouracil
ITMI20030317A1 (it) * 2003-02-21 2004-08-22 Pharmacia Italia Spa Terapia combinata comprendente un derivato dell'indolopirrolocarbazolo ed un altro agente antitumorale.
US20050153885A1 (en) * 2003-10-08 2005-07-14 Yun Anthony J. Treatment of conditions through modulation of the autonomic nervous system
RS50692B (sr) * 2003-11-13 2010-06-30 Pharma Mar S.A.U. Kombinacija et-743 sa prolekovima 5-fluorouracila za lečenje kancera
CA2563502A1 (en) 2004-04-09 2005-10-20 Chugai Seiyaku Kabushiki Kaisha Novel water-soluble prodrug
JP2008501007A (ja) * 2004-05-28 2008-01-17 ファイザー・プロダクツ・インク 異常な細胞増殖を治療するための方法
KR20070034536A (ko) * 2004-06-04 2007-03-28 스미스클라인 비이참 (코르크) 리미티드 암 치료 방법
WO2005117980A1 (en) * 2004-06-04 2005-12-15 Pfizer Products Inc. Method for treating abnormal cell growth
US8569277B2 (en) 2004-08-11 2013-10-29 Palo Alto Investors Methods of treating a subject for a condition
DE112006000873T5 (de) * 2005-04-12 2008-03-06 Elan Pharma International Ltd. Zusammensetzungen mit modifizierter Freisetzung, umfassend ein Fluorcytidin-Derivate zur Behandlung von Krebs
BRPI0613796A2 (pt) * 2005-06-07 2011-02-15 Univ Yale composicões farmacêuticas e seus usos, e métodos de tratamento de cáncer e outras condições ou estados patológicos, por meio do uso de clevudina (lfmau) e telbivudina (ldt)
TW200744603A (en) 2005-08-22 2007-12-16 Chugai Pharmaceutical Co Ltd Novel anticancer concomitant drug
WO2010129545A2 (en) 2009-05-04 2010-11-11 Psivida Us, Inc. Porous silicon drug-eluting particles
HUE027831T2 (en) * 2010-03-12 2016-11-28 Genzyme Corp Combination therapy for breast cancer
CN104622790A (zh) 2010-11-01 2015-05-20 普西维达公司 用于递送治疗剂的可生物侵蚀的硅基装置
WO2014151381A1 (en) 2013-03-15 2014-09-25 Psivida Us, Inc. Bioerodible silicon-based compositions for delivery of therapeutic agents

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JPS57116015A (en) 1981-01-09 1982-07-19 Yakult Honsha Co Ltd Antitumor agent
US4399276A (en) 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
JPS57116074A (en) 1981-01-09 1982-07-19 Yakult Honsha Co Ltd Novel camptothecin derivative and its preparation
US4473692A (en) 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS58154582A (ja) 1982-03-10 1983-09-14 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体およびその製造法
JPS595188A (ja) 1982-06-30 1984-01-12 Yakult Honsha Co Ltd １０−ヒドロキシカンプトテシンの製造法
JPS5951289A (ja) 1982-09-17 1984-03-24 Yakult Honsha Co Ltd 新規な９−置換−カンプトテシン誘導体
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US4981968A (en) 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
CA1332413C (en) 1987-06-25 1994-10-11 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
US5004758A (en) 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH0615547B2 (ja) 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
JP2524804B2 (ja) 1988-03-29 1996-08-14 株式会社ヤクルト本社 新規なカンプトテシン誘導体及びその製造法
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US5552154A (en) * 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
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US5670500A (en) 1995-05-31 1997-09-23 Smithkline Beecham Corporation Water soluble camptothecin analogs
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DK0835258T3 (da) 1995-06-21 2003-02-03 Sod Conseils Rech Applic Hidtil ukendte camptothecin-analoger, fremgangsmåder til fremstilling heraf, anvendelse heraf som lægemidler og farmaceutiske præparater indeholdende disse
IL143920A0 (en) * 1998-12-31 2002-04-21 Sugen Inc 3-heteroarylidenyl-2-indolinone derivatives and pharmaceutical compositions containing the same
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Also Published As

Publication number Publication date
CZ298259B6 (cs) 2007-08-08
HUP0300848A3 (en) 2005-03-29
CY1105803T1 (el) 2011-02-02
PT1278518E (pt) 2007-01-31
US20020068743A1 (en) 2002-06-06
ATE344670T1 (de) 2006-11-15
HUP0300848A2 (hu) 2003-08-28
HRP20020658A2 (en) 2004-12-31
NZ520593A (en) 2004-10-29
CA2401191A1 (en) 2001-08-30
NO20024076D0 (no) 2002-08-27
NO20024076L (no) 2002-08-27
CZ20022892A3 (cs) 2002-11-13
US6503889B2 (en) 2003-01-07
NO324772B1 (no) 2007-12-10
KR20020082856A (ko) 2002-10-31
WO2001062235A2 (en) 2001-08-30
ES2273841T3 (es) 2007-05-16
DE60124387T2 (de) 2007-10-11
US20030096789A1 (en) 2003-05-22
AU6011101A (en) 2001-09-03
MXPA02008355A (es) 2002-12-13
IL150953A0 (en) 2003-02-12
US6664242B2 (en) 2003-12-16
EA005619B1 (ru) 2005-04-28
PL363110A1 (en) 2004-11-15
CA2401191C (en) 2006-05-02
SK12242002A3 (sk) 2003-02-04
EP1278518B1 (en) 2006-11-08
YU64602A (sh) 2005-06-10
BR0108728A (pt) 2003-12-30
EE200200471A (et) 2003-12-15
CN1424912A (zh) 2003-06-18
US20020091132A1 (en) 2002-07-11
EP1278518A2 (en) 2003-01-29
AU785467B2 (en) 2007-07-26
EA200200922A1 (ru) 2003-04-24
KR100717916B1 (ko) 2007-05-11
DE60124387D1 (de) 2006-12-21
JP2003523980A (ja) 2003-08-12
TWI239841B (en) 2005-09-21
WO2001062235A3 (en) 2002-11-14

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