ES2086643T3 - Derivados de camptotecina solubles en agua. - Google Patents
Derivados de camptotecina solubles en agua.Info
- Publication number
- ES2086643T3 ES2086643T3 ES92203263T ES92203263T ES2086643T3 ES 2086643 T3 ES2086643 T3 ES 2086643T3 ES 92203263 T ES92203263 T ES 92203263T ES 92203263 T ES92203263 T ES 92203263T ES 2086643 T3 ES2086643 T3 ES 2086643T3
- Authority
- ES
- Spain
- Prior art keywords
- rent
- perhalo
- hydrogen
- alcoxi
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Abstract
EL INVENTO MUESTRA DERIVADOS DE CAMPTOTECINA SOLUBLES EN AGUA DE LA FORMULA (I), DONDE: N REPRESENTA EL ENTERO 1 O 2; Y I) R1 Y R2 REPRESENTAN INDEPENDIENTEMENTE, HIDROGENO, ALQUILO INFERIOR, CICLOALQUILO (C3-7), ALQUILO INFERIOR CICLOALQUILO (C3 INFERIOR ALCOXI INFERIOR; II) R1 REPRESENTA HIDROGENO, ALQUILO INFERIOR CICLOALQUILO (C3 7), ALQUILO INFERIOR CICLOALQUILO (C3 INFERIOR ALCOXI INFERIOR, Y R2 REPRESENTA ESENTA HIDROGENO, ALQUILO INFERIOR, ALQUILO INFERIOR PERHALO, CICLOALQUILO (C3 ALQUENILO INFERIOR, ALQUILO INFERIOR HIDROXI, ALCOXI INFERIOR, ALQUILO INFERIOR ALCOXI INFERIOR; O III) R1 Y R2 CONJUNTAMENTE CON EL NITROGENO LIGANTE FORMAN UN GRUPO HETEROCICLICO DE 3 A 7 ATOMOS SATURADO DE FORMULA (IA) DONDE : Y REPRESENTA O,S, CH2, NR4 DONDE R REPRESENTA HIDROGENO, ALQUILO INFERIOR, ALQUILO INFERIOR PERHALO, ARILO, ARILO SUSTITUIDO CON UNO O MAS GRUPOS ALQUILO INFERIOR, HALOGENO, NITRO, AMINO, AMINO ALQUILO INFERIOR, ALQUILO INFERIOR PERHALO, ALQUILO INFERIOR HIDROXI, ALCOXI INFERIOR,ALQUILO INFERIOR ALCOXI INFERIOR O; EPRESENTA HIDROGENO, ALQUILO INFERIOR, ALQUILO INFERIOR PERHALO, ALCOXI INFERIOR, ARILO, ARILO SUSTITUIDO CON UNO MAS GRUPO ALQUILO, ALQUILO INFERIOR PERHALO, ALQUILO INFERIOR HIDROXI, ALQUILO INFERIOR ALCOXI INFERIOR ; Y LAS SALES FARMACEUTICAMENTE ACEPTABLES CONSIGUIENTES; SU USO EN EL TRATAMIENTO DE TUMORES Y METODOS DE SU PREPARACION.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78427591A | 1991-10-29 | 1991-10-29 | |
US82672992A | 1992-01-28 | 1992-01-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2086643T3 true ES2086643T3 (es) | 1996-07-01 |
Family
ID=27120258
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92203263T Expired - Lifetime ES2086643T3 (es) | 1991-10-29 | 1992-10-23 | Derivados de camptotecina solubles en agua. |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP0540099B1 (es) |
JP (2) | JP3020760B2 (es) |
KR (1) | KR100246154B1 (es) |
CN (1) | CN1072683A (es) |
AP (1) | AP306A (es) |
AT (1) | ATE136898T1 (es) |
AU (1) | AU657007B2 (es) |
CA (1) | CA2081580A1 (es) |
CZ (1) | CZ284023B6 (es) |
DE (1) | DE69209969T2 (es) |
DK (1) | DK0540099T3 (es) |
ES (1) | ES2086643T3 (es) |
FI (3) | FI104373B (es) |
GR (1) | GR3020120T3 (es) |
HU (2) | HU217970B (es) |
IL (1) | IL103571A (es) |
IS (1) | IS1708B (es) |
MX (1) | MX9206211A (es) |
MY (1) | MY108261A (es) |
NO (1) | NO302073B1 (es) |
NZ (1) | NZ244914A (es) |
OA (1) | OA09767A (es) |
RU (1) | RU2119921C1 (es) |
SK (1) | SK279298B6 (es) |
TW (1) | TW221994B (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5364858A (en) * | 1987-03-31 | 1994-11-15 | Research Triangle Institute | Camptothecin analogs as potent inhibitors of topoisomerase I |
US5552154A (en) | 1989-11-06 | 1996-09-03 | The Stehlin Foundation For Cancer Research | Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof |
US6080751A (en) * | 1992-01-14 | 2000-06-27 | The Stehlin Foundation For Cancer Research | Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof |
AP9300587A0 (en) * | 1992-11-12 | 1995-05-05 | Glaxo Inc | Water soluble camptothecin derivatives. |
WO1994015604A1 (en) * | 1993-01-15 | 1994-07-21 | The Stehlin Foundation For Cancer Research | Transdermal treatment of cancer with water-insoluble s-camptothecin of the closed lactone ring form |
US5369127A (en) * | 1993-04-21 | 1994-11-29 | Allergan, Inc. | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents |
IS4152A (is) * | 1993-04-29 | 1994-10-30 | Glaxo Inc. | Vatnsuppleysanlegar Camptothecin afleiður og aðferð til framleiðslu þeirra |
AU684777B2 (en) * | 1993-05-03 | 1998-01-08 | Smithkline Beecham Corporation | Substituted methylenedioxy(3',4':6,7)indolizino-(1,2-b)quinolinones |
US5447936A (en) * | 1993-12-22 | 1995-09-05 | Bionumerik Pharmaceuticals, Inc. | Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof |
US5491237A (en) * | 1994-05-03 | 1996-02-13 | Glaxo Wellcome Inc. | Intermediates in pharmaceutical camptothecin preparation |
IT1269862B (it) * | 1994-05-30 | 1997-04-15 | Indena Spa | Alcaloidi da mappia foetida, loro uso e formulazioni che li contengono |
US5646159A (en) * | 1994-07-20 | 1997-07-08 | Research Triangle Institute | Water-soluble esters of camptothecin compounds |
KR960029336A (ko) * | 1995-01-09 | 1996-08-17 | 김충환 | 캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제 |
US5496952A (en) * | 1995-02-07 | 1996-03-05 | North Carolina State University | Method of making asymmetric DE ring intermediates for the synthesis of camptothecin and camptothecin analogs |
US5670500A (en) * | 1995-05-31 | 1997-09-23 | Smithkline Beecham Corporation | Water soluble camptothecin analogs |
EP0837850B1 (en) * | 1995-06-27 | 2004-09-01 | Takeda Chemical Industries, Ltd. | 4-acylamino(halogeno) alkyl-quinoline derivatives, their preparation and their use as melatonin agonists |
SG50747A1 (en) * | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
WO1997019085A1 (en) * | 1995-11-22 | 1997-05-29 | Research Triangle Institute | Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties |
CA2192725C (en) | 1995-12-28 | 2004-04-20 | Kenji Tsujihara | Camptothecin derivatives |
TW464652B (en) | 1996-10-30 | 2001-11-21 | Tanabe Seiyaku Co | S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof |
US6559309B2 (en) * | 1996-11-01 | 2003-05-06 | Osi Pharmaceuticals, Inc. | Preparation of a camptothecin derivative by intramolecular cyclisation |
US6207673B1 (en) | 1997-03-12 | 2001-03-27 | The University Of North Carolina At Chapel Hill | Covalent conjugates of topoisomerase I and topoisomerase II inhibitors |
US6046209A (en) * | 1997-05-27 | 2000-04-04 | Smithkline Beecham Corporation | Water soluble camptothecin analogs |
US6288072B1 (en) * | 1999-12-29 | 2001-09-11 | Monroe E. Wall | Camptothecin β-alanine esters with topoisomerase I inhibition |
WO2001062235A2 (en) | 2000-02-28 | 2001-08-30 | Aventis Pharma S.A. | A composition comprising camptothecin and a pyrimidine derivative for the treatment of cancer |
US6545010B2 (en) | 2000-03-17 | 2003-04-08 | Aventis Pharma S.A. | Composition comprising camptothecin or a camptothecin derivative and a platin derivative for the treatment of cancer |
US6548488B2 (en) | 2000-03-17 | 2003-04-15 | Aventis Pharma S.A. | Composition comprising camptothecin or a camptothecin derivative and an alkylating agent for the treatment of cancer |
US6486320B2 (en) | 2000-09-15 | 2002-11-26 | Aventis Pharma S.A. | Preparation of camptothecin and of its derivatives |
MXPA03002882A (es) | 2000-10-27 | 2004-12-03 | Aventis Pharma Sa | Una combinacion que contiene camptotecina y un derivado de estilbeno para el tratamiento del cancer. |
ITRM20040240A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | Camptotecine coniugate in posizione 7 con antagonisti delle integrine. |
WO2012050591A1 (en) | 2010-10-15 | 2012-04-19 | Rutgers, The State University Of New Jersey | Hydrogel formulation for dermal and ocular delivery |
WO2006069344A2 (en) | 2004-12-22 | 2006-06-29 | Rutgers, The State University Of New Jersey | Controlled release hydrogels |
US8410045B2 (en) | 2006-03-30 | 2013-04-02 | Drais Pharmaceuticals, Inc. | Camptothecin-peptide conjugates and pharmaceutical compositions containing the same |
CN101407524B (zh) * | 2007-10-09 | 2012-07-18 | 江苏先声药物研究有限公司 | 噁嗪骈喜树碱衍生物及其制备方法和用途 |
CN100592871C (zh) * | 2008-03-14 | 2010-03-03 | 浙江林学院 | 一种杀虫剂组合物及其加工方法 |
ES2373172B1 (es) * | 2010-07-16 | 2012-12-10 | Consejo Superior De Investigaciones Científicas (Csic) | Proceso de obtención de derivados solubles en agua de 20 (s) camptotecina como agentes antitumorales. |
WO2012096832A2 (en) * | 2011-01-12 | 2012-07-19 | Crystal Biopharmaceutical Llc | Hdac inhibiting derivatives of camptothecin |
BR112020020466A2 (pt) * | 2018-04-06 | 2021-01-12 | Seattle Genetics, Inc. | Conjugados de peptídeo de camptotecina |
CN110590796B (zh) * | 2018-06-12 | 2022-07-15 | 青岛海洋生物医药研究院股份有限公司 | 喜树碱衍生物及其制备方法和应用 |
JP2024532768A (ja) * | 2021-08-19 | 2024-09-10 | ハイナン シムセレ ザイミン ファーマシューティカル カンパニー リミテッド | カンプトテシン誘導体、その薬物組成物およびその応用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
-
1992
- 1992-10-23 EP EP92203263A patent/EP0540099B1/en not_active Expired - Lifetime
- 1992-10-23 ES ES92203263T patent/ES2086643T3/es not_active Expired - Lifetime
- 1992-10-23 DK DK92203263.6T patent/DK0540099T3/da active
- 1992-10-23 AT AT92203263T patent/ATE136898T1/de not_active IP Right Cessation
- 1992-10-23 DE DE69209969T patent/DE69209969T2/de not_active Expired - Fee Related
- 1992-10-27 SK SK3237-92A patent/SK279298B6/sk unknown
- 1992-10-27 CZ CS923237A patent/CZ284023B6/cs not_active IP Right Cessation
- 1992-10-27 TW TW081108539A patent/TW221994B/zh active
- 1992-10-28 MX MX9206211A patent/MX9206211A/es unknown
- 1992-10-28 NO NO924158A patent/NO302073B1/no unknown
- 1992-10-28 MY MYPI92001954A patent/MY108261A/en unknown
- 1992-10-28 KR KR1019920019884A patent/KR100246154B1/ko not_active IP Right Cessation
- 1992-10-28 AU AU27385/92A patent/AU657007B2/en not_active Ceased
- 1992-10-28 CA CA002081580A patent/CA2081580A1/en not_active Abandoned
- 1992-10-28 CN CN92113782A patent/CN1072683A/zh not_active Withdrawn
- 1992-10-28 IL IL103571A patent/IL103571A/en not_active IP Right Cessation
- 1992-10-28 FI FI924878A patent/FI104373B/fi active
- 1992-10-28 AP APAP/P/1992/000439A patent/AP306A/en active
- 1992-10-28 IS IS3936A patent/IS1708B/is unknown
- 1992-10-28 HU HU9203384A patent/HU217970B/hu not_active IP Right Cessation
- 1992-10-28 NZ NZ244914A patent/NZ244914A/xx not_active IP Right Cessation
- 1992-10-28 JP JP4312862A patent/JP3020760B2/ja not_active Expired - Fee Related
- 1992-10-28 OA OA60295A patent/OA09767A/en unknown
- 1992-10-28 RU RU92004336A patent/RU2119921C1/ru not_active IP Right Cessation
-
1995
- 1995-06-14 HU HU95P/P00203P patent/HU211349A9/hu unknown
-
1996
- 1996-05-31 GR GR960401497T patent/GR3020120T3/el unknown
-
1998
- 1998-10-08 FI FI982185A patent/FI982185A/fi unknown
-
1999
- 1999-11-02 JP JP31294099A patent/JP3229298B2/ja not_active Expired - Fee Related
-
2002
- 2002-06-07 FI FI20021090A patent/FI20021090A/fi not_active Application Discontinuation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2086643T3 (es) | Derivados de camptotecina solubles en agua. | |
SE9103572D0 (sv) | Organic salts of n,n'-diacetyl cystine | |
ES2040838T3 (es) | Compuestos piperazinil-heterociclicos. | |
CY1108339T1 (el) | Παραγωγα spiro(2h-1-benzopyran-2,4´-piperidine) ως αναστολεις της μεταφορας γλυκινης | |
MX9203550A (es) | Derivados de 4-aminoquinolina y su uso como medicamentos. | |
ES2164889T3 (es) | Semicarbazonas con actividad sobre el snc y preparados farmaceuticos a base de las mismas. | |
IT8719964A0 (it) | Sali organici di derivati della fisostigmina | |
NO157643C (no) | Anvendelse av sitronsyre for aa forhindre nedbrytning av farmasoeytisk taalbare syreaddisjonssalter av tienopyridinderivater. | |
FR2299867A1 (fr) | Derives amines d'imidazo(4,5-b)pyridines | |
SE7811455L (sv) | 2-imino-imidazolidin-derivat | |
BE816049A (fr) | Derives d'acides benzodioxole-1 | |
DE69032000D1 (de) | Behandlung kardialer Dysfunktion mit 15-Ketoprostaglandinderivaten | |
DE69023459D1 (de) | Behandlung von pulmonarer Disfunktion mit 15-Keto-prostaglandin-Derivaten. | |
FI883930A (fi) | Analogiamenetelmä terapeuttisesti käyttökelpoisten bentsimidatsolijohdannaisten valmistamiseksi | |
ES2043515B1 (es) | Procedimiento para la preparacion de nuevos derivados de 1-difenilmetilpiperazina. | |
LV10098A (lv) | Metilpiperazinazepina atvasinajumi to iegusana un lietosana | |
AR248127A1 (es) | Procedimiento para la preparacion de nuevas 2-aminotetralinas sustituidas en la posicion 8. | |
ES2046528T3 (es) | Derivados heterotetraciclicos de lactamas, proceso para su preparacion y composiciones farmaceuticas a base de los mismos. | |
DK0466662T3 (da) | 6,7-Disubstituerede-2-aminotetraliner, der er aktive som immunmodulatorer, samt farmaceutiske præparater indeholdende sådanne forbindelser | |
BE849726A (fr) | Alpha-nonoacetals de derives d'acides alpha, beta-dioxo-carboxyliques, utililsables comme inducteurs de photopolymerisation | |
ES2061490T3 (es) | Derivados de perhidrotiazepina y perhidroazepina, su preparacion y uso en terapeutica. | |
IT7819945A0 (it) | Procedimento per la produzione di derivati dell'indolina. | |
ES361664A1 (es) | Procedimiento para la preparacion de nuevo acido antrani- lico. | |
ES2032838T3 (es) | Un procedimiento para preparar derivados tetrahidropirido (1,2-a)indol. | |
BE802539A (fr) | Derives d'acides phenoxy-alicycliques-carboxyliques |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 540099 Country of ref document: ES |